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https://www.readbyqxmd.com/read/29772938/the-suppressive-effect-of-the-three-herb-extract-mixture-on-vascular-and-liver-inflammation-in-atherogenic-diet-with-high-fructose-fed-mice
#1
Hae Seong Song, Hyun Jung Koo, Bong Kyun Park, Jeong Eun Kwon, Seon-A Jang, Hyun Jin Baek, Se Young Kim, Sung Ryul Lee, Se Chan Kang
CONTEXT: Cynanchum wilfordii (Maximowicz) Hemsley (Apocynaceae), Arctium lappa L. var. rubescens Frivald (Asteraceae) and Dioscorea opposite Thunb (Dioscoreaceae) root extracts have been widely used as an alternative for intervening obesity. OBJECTIVES: The synergistic effect of three-herb mixture of C. wilfordii, A. lappa and D. opposita was determined on aortic and liver inflammatory responses. MATERIALS AND METHODS: CWE, ALE and DOE were prepared from the root of C...
December 2018: Pharmaceutical Biology
https://www.readbyqxmd.com/read/29771268/hiv-disease-is-associated-with-increased-biomarkers-of-endothelial-dysfunction-despite-viral-suppression-on-long-term-antiretroviral-therapy-in-botswana
#2
Mosepele Mosepele, Terence Mohammed, Lucy Mupfumi, Sikhulile Moyo, Kara Bennett, Shahin Lockman, Linda C Hemphill, Virginia A Triant
BACKGROUND: Untreated HIV infection is associated with increased biomarkers of endothelial dysfunction. However, the predictors and degree of endothelial dysfunction among virally suppressed HIV-infected adults on long-term antiretroviral therapy (ART) have not been well studied in sub-Saharan Africa (SSA). METHODS: We enrolled 112 HIV-infected adults with virological suppression on long-term ART and 84 HIV-uninfected controls in Botswana. We measured plasma levels of markers of endothelial injury [soluble vascular adhesion molecule 1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1) and E-selectin] and plasma levels of biomarkers of inflammation [interleukin 6 (IL-6)] and monocyte activation (sCD163)...
May 14, 2018: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/29766401/penehyclidine-hydrochloride-decreases-pulmonary-microvascular-endothelial-inflammatory-injury-through-a-beta-arrestin-1-dependent-mechanism
#3
Fei Zheng, Fei Xiao, Qing-Hong Yuan, Qiang-Sheng Liu, Zong-Ze Zhang, Yan-Lin Wang, Jia Zhan
Penehyclidine hydrochloride (PHC), a type of hyoscyamus drug, has both antimuscarinic and antinicotinic activities and retains potent central and peripheral anticholinergic activities. Compared with other hyoscyamine, the notable advantage of PHC is that it has few M2 receptor-associated cardiovascular side effects. Recent studies and clinical trials have suggested that treatment with penehyclidine hydrochloride may also possess good effects in the treatment of lung injury. The mechanism responsible for this effect has yet to be determined; however, one possibility is that they might do so by a direct effect on pulmonary vascular endothelium...
May 15, 2018: Inflammation
https://www.readbyqxmd.com/read/29763921/peptidomic-analysis-of-endometrial-tissue-from-patients-with-ovarian-endometriosis
#4
Yunping Xue, Pengfei Xu, Sujuan Xu, Kai Xue, Lingling Xu, Jie Chen, Juan Xu, Xiaoyan Shi, Qian Li, Lin Gu
BACKGROUND/AIMS: Ovarian endometriosis (OvE) is ovarian cyst that is lined with endometrial tissue. They are found in 17-44% of women with endometriosis. Their clinical manifestations include pelvic pain, dysmenorrhea, dyspareunia, and infertility. Although the incidence of OvE has increased yearly, the exact pathogenesis of OvE is still unclear. We used peptidomics, an emerging branch of proteomics, to identify differentially expressed peptides in order to determine the possible roles of these peptides in the pathogenesis of OvE...
May 9, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29763440/endothelium-targeted-delivery-of-dexamethasone-by-anti-vcam-1-saint-o-somes-in-mouse-endotoxemia
#5
Ranran Li, Piotr S Kowalski, Henriëtte W M Morselt, Ilona Schepel, Rianne M Jongman, Adnan Aslan, Marcel H J Ruiters, Jan G Zijlstra, Grietje Molema, Matijs van Meurs, Jan A A M Kamps
Microvascular endothelial cells play a pivotal role in the pathogenesis of sepsis-induced inflammatory responses and multiple organ failure. Therefore, they represent an important target for pharmacological intervention in the treatment of sepsis. Glucocorticosteroids were widely used in the treatment of sepsis but vast evidence to support their systemic use is lacking. The limited effects of glucocorticoids in the treatment of sepsis may be explained by differential effects of drug initiated NF-κB inhibition in different cell types and insufficient drug delivery in target cells...
2018: PloS One
https://www.readbyqxmd.com/read/29761929/assessment-of-polycyclic-aromatic-hydrocarbon-exposure-lung-function-systemic-inflammation-and-genotoxicity-in-peripheral-blood-mononuclear-cells-from-firefighters-before-and-after-a-work-shift
#6
Maria Helena Guerra Andersen, Anne Thoustrup Saber, Julie Elbaek Pedersen, Peter Bøgh Pedersen, Per Axel Clausen, Mille Løhr, Ali Kermanizadeh, Steffen Loft, Niels E Ebbehøj, Åse Marie Hansen, Ismo Kalevi Koponen, Eva-Carina Nørskov, Ulla Vogel, Peter Møller
Firefighting is regarded as possibly carcinogenic, although there are few mechanistic studies on genotoxicity in humans. We investigated exposure to polycyclic aromatic hydrocarbons (PAH), lung function, systemic inflammation and genotoxicity in peripheral blood mononuclear cells (PBMC) of 22 professional firefighters before and after a 24-h work shift. Exposure was assessed by measurements of particulate matter (PM), PAH levels on skin, urinary 1-hydroxypyrene (1-OHP) and self-reported participation in fire extinguishing activities...
May 15, 2018: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/29751537/-mcpip3-as-a-potential-metastasis-suppressor-gene-in-human-colorectal-cancer
#7
Fat-Moon Suk, Chi-Ching Chang, Ren-Jye Lin, Shyr-Yi Lin, Ya-Ting Chen, Yu-Chih Liang
Monocyte chemotactic protein induced protein 3 (MCPIP3) belongs to the Cys⁻Cys⁻Cys⁻His (CCCH)-zinc finger protein family and contains a highly conserved CCCH-zinc finger domain and a Nedd4-BP1 YacP nuclease (NYN) domain. Previous studies showed that MCPIP3 inhibits the expression of proinflammatory genes, such as vascular cell adhesion molecule ( VCAM )-1, in human endothelial cells, but the roles and functions of MCPIP3 in cancer cells are still unknown. In human colorectal cancer specimens, we found that the messenger RNA expression of MCPIP3 was significantly downregulated in cancer tissues compared to adjacent normal tissues (18/25; average fold change of 8...
May 3, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29750963/concentration-and-value-of-endocan-on-outcome-in-adult-patients-after-severe-sepsis
#8
Sheng-Yuan Hsiao, Chia-Te Kung, Nai-Wen Tsai, Chih-Min Su, Chin-Cheng Huang, Yun-Ru Lai, Hung-Chen Wang, Ben-Chung Cheng, Yu-Jih Su, Wei-Che Lin, Yi-Fang Chiang, Cheng-Hsien Lu
BACKGROUND: Endothelial dysfunction plays a central role in severe sepsis. Endocan is constitutively expressed in human endothelial cells when sepsis occurs. We tested the hypothesis that endocan concentrations are substantially increased in severe sepsis and decrease after antimicrobial therapy, and that endocan concentrations can predict treatment outcomes. METHODS: Biomarkers of the endothelium including endocan and cell adhesion molecules were prospectively evaluated in 153 patients with severe sepsis on days 1, 4, and 7 after admission along with biochemical and clinical data...
May 8, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29750887/the-effects-of-acute-hypoxia-on-tissue-oxygenation-and-circulating-alarmins-in-healthy-adults
#9
C J Boos, C M Lamb, M Midwinter, A Mellor, D R Woods, M Howley, T Stansfield, M Foster, J P O'hara
The binding of high-mobility group box-1 (HMGB-1) to the membrane receptor for advanced glycation end-products (mRAGE) is a key early mediator of non-infectious inflammation and its triggers include ischaemia/hypoxia. The effects of acute hypoxia on soluble RAGE (sRAGE) are unknown. Fourteen healthy adults (50% women; 26.6+/-3.8 years) were assessed at baseline normoxia (T0), followed by four time-points (T90, 95, 100 and 180 minutes) over three hours of continuous normobaric hypoxia (NH, 4450m equivalent) and again 60 minutes after return to normoxia (T240)...
May 10, 2018: Physiological Research
https://www.readbyqxmd.com/read/29748730/corynoline-exhibits-anti-inflammatory-effects-in-lipopolysaccharide-lps-stimulated-human-umbilical-vein-endothelial-cells-through-activating-nrf2
#10
Bin Liu, Kai Su, Jiaxin Wang, Jingjing Wang, Zhuoyuan Xin, Fan Li, Yunhe Fu
Corynoline, a bioactive compound isolated from Corydalis bungeana Turcz., has been known to have anti-inflammatory activity. However, its effects on the inflammation of the cardiovascular system have not been reported yet. The aim of this study was to investigate the anti-inflammatory effects of corynoline on lipopolysaccharide (LPS)-stimulated human umbilical vein endothelial cells (HUVECs). The results showed that LPS significantly increased the expression of VCAM-1 and ICAM-1. The production of cytokines TNF-α and IL-8 was also up-regulated by LPS...
May 11, 2018: Inflammation
https://www.readbyqxmd.com/read/29740431/omics-based-approach-reveals-complement-mediated-inflammation-in-chronic-lymphocytic-inflammation-with-pontine-perivascular-enhancement-responsive-to-steroids-clippers
#11
Morten Blaabjerg, Anne Louise Hemdrup, Lylia Drici, Klemens Ruprecht, Peter Garred, Romana Höftberger, Bjarne W Kristensen, Daniel Kondziella, Tobias Sejbaek, Soren W Hansen, Helle H Nielsen, Pia Jensen, Morten Meyer, Friedemann Paul, Hans Lassmann, Martin R Larsen, Zsolt Illes
Objective: Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is a rare syndrome with relapsing brainstem/cerebellar symptoms. To examine the pathogenic processes and investigate potential biomarkers, we analyzed combined materials of brain and cerebrospinal fluid (CSF) by comprehensive methodologies. Materials and methods: To identify major pathways of perivascular inflammation in CLIPPERS, we first compared the CSF proteome ( n  = 5) to a neurodegenerative condition, Alzheimer's disease (AD, n  = 5)...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29728095/puerarin-inhibits-vascular-smooth-muscle-cells-proliferation-induced-by-fine-particulate-matter-via-suppressing-of-the-p38-mapk-signaling-pathway
#12
Qiang Wan, Zhongyong Liu, Yuping Yang
BACKGROUND: Fine particulate matter (PM2.5) is a major risk factor for the development and progression of atherosclerosis. Proliferation and infiltration of vascular smooth muscle cells (VSMCs) from the blood vessel media into the intima is a crucial step in the pathophysiology of atherosclerosis. Puerarin, a natural extract from Radix Puerariae, possesses significant anti-atherosclerosis properties. However, the underlying molecular mechanisms responsible for the effect of puerarin on the VSMCs proliferation induced by PM2...
May 4, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29724533/targeting-phosphodiesterase-5-by-vardenafil-improves-vascular-graft-function
#13
Gábor Veres, Martin Hagenhoff, Harald Schmidt, Tamás Radovits, Sivakkanan Loganathan, Yang Bai, Sevil Korkmaz-Icöz, Paige Brlecic, Alex Ali Sayour, Matthias Karck, Gábor Szabó
OBJECTIVES: Ischaemia reperfusion (IR) injury occurs during vascular graft harvesting and implantation during vascular/cardiac surgery. Elevated intracellular cyclic guanosine monophosphate (cGMP) levels contribute to an effective endothelial protection in different pathophysiological conditions. The hypothesis that the phosphodiesterase-5 inhibitor vardenafil would protect vascular grafts against IR injury by upregulating the nitric oxide-cGMP pathway in the vessel wall of the bypass graft was investigated...
May 1, 2018: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29723873/antibodies-against-hdl-components-in-ischaemic-stroke-and-coronary-artery-disease
#14
Joana R Batuca, Marta C Amaral, Catarina Favas, Gonçalo C Justino, Ana L Papoila, Paul R J Ames, José Delgado Alves
Quantitative and qualitative defects of high-density lipoprotein (HDL) are important in atherogenesis. In this study, we investigated whether antibodies against HDL components had additional value to conventional cardiovascular risk factors for the diagnosis of ischaemic stroke (IS) and coronary artery disease (CAD). Cross-sectional study was conducted on 53 patients with IS, 51 with CAD and 55 healthy controls, and in vitro studies to validate findings of the clinical study. We determined serum immunoglobulin G (IgG) antibodies against HDL (aHDL), apolipoproteins (aApoA-I, aApoA-II and aApoC-I) and paraoxonase-1 (aPON1) as well as PON1 activity (PON1a), total antioxidant capacity and biomarkers of endothelial activation (serum nitric oxide metabolites, 3-nitrotyrosine, VCAM-1 and ICAM-1); in vitro assays tested the capacity of IgG aHDL purified from high titer patients to inhibit PON1a and to reverse protective effect of HDL on endothelial cells...
May 3, 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29723698/erk5-klf2-activation-is-involved-in-the-reducing-effects-of-puerarin-on-monocyte-adhesion-to-endothelial-cells-and-atherosclerotic-lesion-in-apolipoprotein-e-deficient-mice
#15
Yan Deng, Tingwen Lei, Hongmei Li, Xiaochuan Mo, Zhuting Wang, Hailong Ou
Puerarin has properties of anti-oxidation and anti-inflammation, which has been demonstrated protective effects in atherosclerosis and other cardiovascular diseases. However, the detail molecular mechanism still remains unclear. Here, we determined whether the atheroprotective effect of puerarin was by reducing monocyte adhesion and explored the underlying mechanism. The results showed that puerarin dose- and time-dependently reduced oxLDL-induced monocyte THP-1 adhesion to HUVECs and the expression of adhesion-related genes such as VCAM-1, ICAM-1, MCP-1 and IL-8 in HUVECs...
April 30, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29720943/microrna-200a-200b-modulate-high-glucose-induced-endothelial-inflammation-by-targeting-o-linked-n-acetylglucosamine-transferase-expression
#16
Wan-Yu Lo, Wen-Kai Yang, Ching-Tien Peng, Wan-Yu Pai, Huang-Joe Wang
Background and Aims: Increased O -linked N -acetylglucosamine ( O -GlcNAc) modification of proteins by O -GlcNAc transferase (OGT) is associated with diabetic complications. Furthermore, oxidative stress promotes endothelial inflammation during diabetes. A previous study reported that microRNA-200 (miR-200) family members are sensitive to oxidative stress. In this study, we examined whether miR-200a and miR-200b regulate high-glucose (HG)-induced OGT expression in human aortic endothelial cells (HAECs) and whether miRNA-200a/200b downregulate OGT expression to control HG-induced endothelial inflammation...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29717364/acute-promyelocytic-leukemia-cell-adhesion-to-vascular-endothelium-is-reduced-by-heparins
#17
Alfonso Vignoli, Marina Marchetti, Anna Falanga
Adhesion of acute promyelocytic leukemia (APL) cells to endothelial cells (EC) is among the mechanisms of the APL-associated coagulopathy, responsible for early hemorrhagic deaths in affected patients. We compared the effects of dalteparin and enoxaparin, two low-molecular-weight heparins (LMWH), and unfractionated heparin (UFH), on APL NB4 adhesion to micro- (HMEC-1) and macro-vascular EC (HUVEC), in resting and interleukin-1β (IL-1β)-stimulated conditions. The heparin effect on EC adhesion molecule (ICAM-1, VCAM-1, E-selectin) expression was also assessed...
May 1, 2018: Annals of Hematology
https://www.readbyqxmd.com/read/29710549/human-cytomegalovirus-infection-induced-autophagy-was-associated-with-the-biological-behavioral-changes-of-human-umbilical-vein-endothelial-cell-huvec
#18
Jun Zhao, Feng Zhong, Haiyang Yu, Zhiwu Chen, Mingli Wang, Jason Chen
In this study, we investigated the enacted role of autophagy in biological behavioral changes of human umbilical vein endothelial cell (HUVEC) infected with human cytomegalovirus (HCMV). It was found that in HCMV-infected cells, the number of punctuate structures increased from 24 h to 48 h p.i. while decreased at 60 h p.i. by GFP-LC3 tranfecting, Monodansylcadaverine (MDC), acridine orange (AO) staining, which suggested that autophagy was induced at early stage, but it was inhibited at later stage in responding to HCMV infection...
March 31, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29700607/cerebrovascular-inflammation-is-associated-with-tau-pathology-in-guam-parkinsonism-dementia
#19
Petra Majerova, Ralph M Garruto, Andrej Kovac
Parkinsonism-dementia complex of Guam (Guam PDC) is a neurodegenerative disease with parkinsonism and early onset Alzheimer-like dementia. Guam PDC belongs to the family of neurodegenerative disorders, known as tauopathies, which are histopathologically characterized by abnormal deposition of microtubule-associated protein tau. While changes in the blood-brain barrier (BBB) in Alzheimer's disease are increasingly recognized, dysfunction of BBB in Guam PDC has not been extensively studied. In this study, we characterized cerebrovascular changes in the patients with Guam PDC...
April 26, 2018: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29690499/levels-of-soluble-endothelium-adhesion-molecules-and-complications-among-sickle-cell-disease-patients-in-ghana
#20
Charles Antwi-Boasiako, Eric S Donkor, Fredericka Sey, Bartholomew Dzudzor, Gifty B Dankwah, Kate H Otu, Alfred Doku, Campbell A Dale, Ivy Ekem
BACKGROUND: Soluble adhesion molecules are involved in the gathering and joining of inflammatory cells to vascular endothelium. Therefore, they serve as potential markers of endothelial dysfunction in vascular diseases including sickle cell disease (SCD). In Ghana, there are scarcely any report on the levels of adhesion molecules among SCD patients. The current study aimed to determine plasma levels of ICAM-1, VCAM-1 and E-Selectin as markers of endothelial dysfunction in SCD patients in steady state, complications and controls...
April 21, 2018: Diseases (Basel)
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