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Carcinoma vulva

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https://www.readbyqxmd.com/read/28213066/inguinal-lymph-node-presenting-as-the-delayed-site-of-metastasis-in-early-stage-endometrial-carcinoma-case-report
#1
Shomaila Amir M Akbar, Mutahir A Tunio, Wafa AlShakweer, AbdulAziz AlObaid, Mushabbab AlAsiri
INTRODUCTION: Inguinal lymph nodes are the frequent sites of metastasis for malignant lymphoma, squamous cell carcinoma of anal canal, vulva and penis, malignant melanoma and squamous cell carcinoma of skin over lower extremities or trunk. Anatomically, endometrial carcinoma is less likely to spread to the superficial or deep inguinal lymph nodes, thus metastatic involvement of these lymph nodes can easily be overlooked. CASE PRESENTATION: Here-in we report a case of a 65-year old Saudi morbid obese female, who presented with left inguinal lymphadenopathy as initial delayed site of metastasis almost 19 months after the initial treatment for FIGO IA endometrial carcinoma...
January 19, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28194353/labia-majora-share
#2
Hanjing Lee, Yan Lin Yap, Jeffrey Jen Hui Low, Jane Lim
Defects involving specialised areas with characteristic anatomical features, such as the nipple, upper eyelid, and lip, benefit greatly from the use of sharing procedures. The vulva, a complex 3-dimensional structure, can also be reconstructed through a sharing procedure drawing upon the contralateral vulva. In this report, we present the interesting case of a patient with chronic, massive, localised lymphedema of her left labia majora that was resected in 2011. Five years later, she presented with squamous cell carcinoma over the left vulva region, which is rarely associated with chronic lymphedema...
January 2017: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/28191812/moderately-differentiated-neuroendocrine-cell-carcinoma-of-the-vulva-a-case-report-and-review-of-the-literature
#3
Soheila Aminimoghaddam, A Maghsoudnia, S Shafiee
Primary vulvar neuroendocrine carcinoma are extremely rare. There have been few cases of these tumors most of which have been considered as Merkel cell carcinoma. This report describes a moderately differentiated neuroendocrine cell carcinoma that was not compatible to any of previously reported cases. The patient underwent left hemivulvectomy and bilateral inguinal lymph node dissection. Pathology examination revealed a 5×5 cm mass with no lymph node involvement. Post-op evaluation ruled out any regional and distant metastasis and thereby did not receive chemotherapy or radiotherapy...
September 2016: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/28186972/recurrent-fusion-transcripts-in-squamous-cell-carcinomas-of-the-vulva
#4
Marta Brunetti, Antonio Agostini, Ben Davidson, Claes G Tropé, Sverre Heim, Ioannis Panagopoulos, Francesca Micci
Juxtaposition of two different genes or gene parts due to chromosomal rearrangement is a well-known neoplasia-associated pathogenetic mechanism. The detection and characterization of such tumorigenic fusions is of great importance both research-wise, diagnostically because they may be specific for distinct tumor entities, and because they may serve as therapeutic targets for antioncogenic drugs that interact directly with the molecular changes responsible for neoplastic transformation.At present, more than 10,000 fusion transcripts have been reported in different types of neoplasia, with one tenth of them being identified in squamous cell carcinomas (SCC) of different locations...
February 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28144815/does-p53-codon-72-polymorphism-have-a-prognostic-value-in-carcinoma-of-the-vulva-and-vagina
#5
Alvida Qvick, Bengt Sorbe, Gisela Helenius, Mats G Karlsson, Gabriella Lillsunde Larsson
Human papilloma virus (HPV) is considered to be responsible for a large part of vaginal and vulvar carcinomas, and the p53 codon 72 polymorphism has been implicated in susceptibility to cancer induced by this virus, but with contradicting results. In this study, we have investigated the prognostic value of the codon 72 polymorphism by real-time PCR (qPCR) in two cohorts of vaginal (n = 66) and vulvar (n = 123) carcinomas. In vaginal carcinoma, arginine homozygous patients were significantly associated with a higher primary cure rate (p = 0...
March 2017: Medical Oncology
https://www.readbyqxmd.com/read/28138393/clinical-features-and-treatment-of-vulvar-merkel-cell-carcinoma-a-systematic-review
#6
REVIEW
Austin Huy Nguyen, Ahmed I Tahseen, Adam M Vaudreuil, Gabriel C Caponetti, Christopher J Huerter
BACKGROUND: Merkel cell carcinoma is a rare and aggressive neoplasm originating from mechanoreceptor Merkel cells of the stratum basale of the epidermis. Cases affecting the vulva are exceedingly rare, with the currently available literature primarily in case report form. BODY: Systematic review of the PubMed database returned 17 cases of Merkel cell carcinoma affecting the vulva. Patients presented at a mean age of 59.6 years with a firm, mobile vulvar mass. Symptoms of pain, erythema, pruritus, edema, and ulceration have been reported...
2017: Gynecologic Oncology Research and Practice
https://www.readbyqxmd.com/read/28120596/adenoid-cystic-carcinoma-of-bartholin-s-gland-case-report
#7
Mazdak Momeni, Yelena Korotkaya, Gonzalo Carrasco, Monica Prasad-Hayes
Primary adenoid cystic carcinoma (ACC) of Bartholin's gland is a rare gynecologic malignancy. We report a case of locally advanced ACC of Bartholin's gland. A 62-year-old presented with left Bartholin's gland carcinoma and underwent left radical vulvectomy, left-sided inguinal-femoral lymph node dissection, posterior pelvic exenteration, and pedicle abdominal muscle flap. On her 3 months follow-up exam she was disease free.Pelvic exenteration for thetreatment of this rare disease in the vulva is a potential curative option...
December 2016: Acta Medica Iranica
https://www.readbyqxmd.com/read/28108013/detection-of-extra-regional-tumour-recurrence-with-18-f-fdg-pet-ct-in-patients-with-recurrent-gynaecological-malignancies-being-considered-for-radical-salvage-surgery
#8
H Brar, T May, N Tau, D Langer, P MacCrostie, K Han, U Metser
AIM: To compare the detection rate of extra-regional metastases in patients with recurrent gynaecological malignancies being considered for radical salvage surgery with combined 2-[(18)F]-fluoro-2-deoxy-d-glucose ((18)F-FDG) positron-emission tomography (PET)/computed tomography (CT) compared to conventional imaging. MATERIALS AND METHODS: A retrospective review was performed of all patients in a provincial database with recurrent gynaecological malignancies being considered for pelvic exenteration that underwent restaging with CT/PET between March 2011 and October 2014...
January 17, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28081287/current-insights-into-the-aetiology-pathobiology-and-management-of-local-disease-recurrence-in-squamous-cell-carcinoma-of-the-vulva-a-review-paper
#9
REVIEW
Jason Yap, Danielle O'Neill, Sangeetha Nagenthiran, Christopher Dawson, David Luesley
Squamous cell carcinoma of the vulva is predominantly a disease of the elderly, where the mainstay of treatment is radical surgery. Local vulval recurrence (LVR) is a significant problem for these patients, and the rates of recurrence have not improved over the last three decades. Disappointingly, we still lack an understanding of how LVRs develop and the best approach to prevent and manage the condition. This review discusses recent insights into the key prognostic factors that influence the risk of recurrence, focusing on the role of tumour-adjacent non-neoplastic epithelial disorders, which are thought to play a causative role...
January 12, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28063696/association-of-post-treatment-positron-emission-tomography-with-locoregional-control-and-survival-after-radiation-therapy-for-squamous-cell-carcinoma-of-the-vulva
#10
Yuan James Rao, Comron Hassanzadeh, Anupama Chundury, Caressa Hui, Barry A Siegel, Farrokh Dehdashti, Todd DeWees, Daniel Mullen, Matthew A Powell, David G Mutch, Julie K Schwarz, Perry W Grigsby
BACKGROUND/PURPOSE: The aim of this study was to investigate the use of post-treatment F-18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) for vulvar cancer and compare metabolic response to clinical outcomes. MATERIALS/METHODS: This retrospective study included 21 patients with vulvar squamous cell carcinoma treated with curative-intent radiation between 2007 and 2015. All patients received intensity-modulated radiation treatment (IMRT), a pre-treatment FDG/PET-CT, and a post-treatment FDG-PET/CT performed at a median time of 3months post-IMRT...
January 4, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28061900/a-clitoral-verrucous-carcinoma-in-an-area-of-lichen-planus-has-aggressive-features
#11
Wiebren A A Tjalma, Vasiliki Siozopoulou, Manon T Huizing
BACKGROUND: Verrucous carcinoma of the vulva is extremely rare. It is a slow growing, low malignant variant of a squamous cell carcinoma with a cauliflower appearance. Women with lichen planus have an increased risk of developing vulval cancer. CASE PRESENTATION: A 79-year-old woman consulted for vulval itching. On clinical examination, a 3-cm large verrucous clitoral cancer in an area of lichen planus was seen. Based on her last clinical examination, the growth was estimated to be 1 cm(2) per month with an invasion depth after 6 months of 5 mm...
January 6, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28040722/surgical-management-of-vulvar-cancer
#12
REVIEW
Thanh H Dellinger, Amy A Hakim, Stephen J Lee, Mark T Wakabayashi, Robert J Morgan, Ernest S Han
Vulvar cancer is a rare malignancy with high curability in early-stage disease, yet poor outcomes for advanced-stage and recurrent disease. Surgical management is at the cornerstone of treatment for most vulvar cancers, and includes conservative and radical resection of the primary vulvar tumor and excision of local lymph nodes, which are major prognostic factors and drive adjuvant treatment. This review summarizes the surgical management of primary squamous cell carcinoma of the vulva, specifically initial treatment guidelines by stage, based on the 2017 NCCN Clinical Practice Guidelines in Oncology for Vulvar Cancer...
January 2017: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/27960241/the-changing-landscape-of-gynaecological-cancer-diagnosis-implications-for-histopathological-practice-in-the-21st-century
#13
REVIEW
Naveena Singh, C Blake Gilks
The era of molecular medicine has led to dramatically improved understanding of the genetic events that give rise to different types of cancers. In the case of gynaecological malignancies, this has resulted in distinct shifts in how these tumours are diagnosed in routine surgical pathology practice, with an increased emphasis on accurate subtype diagnosis. This has happened across all sites in the gynaecological tract and for most cell types, but in ways that are site-specific and may appear to be subtle, as in most instances the diagnostic terminology has not changed...
January 2017: Histopathology
https://www.readbyqxmd.com/read/27900089/pregnancy-and-cesarean-delivery-after-multimodal-therapy-for-vulvar-carcinoma-a-case-report
#14
Kuniaki Toriyabe, Haruki Taniguchi, Tokihiro Senda, Masako Nakano, Yoshinari Kobayashi, Miho Izawa, Hirohiko Tanaka, Tetsuo Asakura, Tsutomu Tabata, Tomoaki Ikeda
Reports of pregnancy following treatment for vulvar carcinoma are extremely uncommon, as the main problem of subsequent pregnancy is vulvar scarring following radical surgery. We herein report the case of a patient who was diagnosed with stage I squamous cell carcinoma of the vulva at the age of 17 years and was treated with multimodal therapy, including neoadjuvant chemotherapy, wide local excision with bilateral inguinal lymph node dissection and adjuvant radiotherapy. The patient became pregnant spontaneously 9 years after her initial diagnosis and the antenatal course was good, except for mild acute pyelonephritis at 25 weeks of gestation...
November 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27896230/evaluation-of-symptoms-and-prevention-of-cancer-in-menopause-the-value-of-vulvar-exam
#15
A R Palumbo, C Fasolino, G Santoro, V Gargano, M Rinaldi, B Arduino, M Belli, M Guida
Vulvar and vaginal atrophy (VVA), is a chronic medical condition experienced by postmenopausal women, with prevalence estimated ranging from 10% to 50% [1]. VVA is characterized by a constellation of symptoms, that may affect daily activities, sexuality, relationships, and quality of life [3]. Early recognition and effective treatment of VVA may enhance sexual health and the quality of life of women and their partners. Some vulvar conditions such as lichen sclerosus are more prevalent in the postmenopausal years...
November 2016: Translational Medicine @ UniSa
https://www.readbyqxmd.com/read/27870714/robotic-assisted-video-endoscopic-inguinal-lymphadenectomy-in-carcinoma-vulva-our-experiences-and-intermediate-results
#16
Vandana Jain, Rupinder Sekhon, Shveta Giri, Nahida Hassan, Kanika Batra, Swati H Shah, Sudhir Rawal
OBJECTIVES: To describe the technique of robotic-assisted video endoscopic inguinal lymphadenectomy (R-VEIL) in patients with carcinoma vulva and discuss the advantages of the technique and oncological outcome. METHODS: Twelve patients of squamous cell cancer of vulva underwent 22 R-VEIL procedures from February 2011 to February 2015. Their preoperative, intraoperative, and postoperative data were retrospectively analysed. RESULTS: The mean age of patients was 61 years (range, 32-78 years)...
January 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27844049/sebaceous-carcinoma-of-the-vulva-a-case-report-and-review-of-the-literature
#17
Stephanie A Sullivan, Arthur-Quan Tran, Siobhan O'Connor, Paola A Gehrig
•Sebaceous carcinoma (SC) is rare with only nine cases reported in the literature.•Extraocular SC likely has similar prognosis to ocular SC.•Reporting of vulvar SC should include detailed pathologic information so that risk factor associations can be made.
November 2016: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/27835588/expressions-of-mir-30c-and-let-7a-are-inversely-correlated-with-hmga2-expression-in-squamous-cell-carcinoma-of-the-vulva
#18
Antonio Agostini, Marta Brunetti, Ben Davidson, Claes G Trope, Sverre Heim, Ioannis Panagopoulos, Francesca Micci
Malignant tumors of the vulva, most of them squamous cell carcinomas, account for only 5% of cancers of the female genital tract. Though little is known about the genetic features of these tumors, the Fragile Histidine Triad (FHIT) and High Mobility Group AT-hook 2 (HMGA2) genes were found deregulated. We wanted to gain more knowledge about the expression of HMGA2-related miRNAs such as miR-30c and let-7a, and whether a correlation exists between the expression of FHIT and HMGA2, in this tumor type. An inverse correlation was found in-as-much as HMGA2 was highly expressed (mean fold change 8...
November 7, 2016: Oncotarget
https://www.readbyqxmd.com/read/27832810/eccrine-porocarcinoma-of-the-vulva-a-case-report-and-review-of-the-literature
#19
Ayako Fujimine-Sato, Masafumi Toyoshima, Shogo Shigeta, Asami Toki, Takashi Kuno, Izumi Sato, Mika Watanabe, Hitoshi Niikura, Nobuo Yaegashi
BACKGROUND: Malignant tumors arising from the vulva account for only 0.6 % of all cancers in female patients. The predominant histologic type, representing about 90 % of these malignancies, is squamous cell carcinoma. Eccrine porocarcinoma is a rare malignant tumor arising from sweat glands. The incidence of eccrine porocarcinoma is estimated at 0.005-0.01 % of all cutaneous tumors. To the best of our knowledge, only seven previous cases of vulvar eccrine porocarcinoma have been reported in the English-language literature...
November 10, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27832422/radiation-induced-lichen-sclerosus-of-the-vulva-first-report-in-the-medical-literature
#20
Lisa R Edwards, Emily D Privette, James W Patterson, Georgi Tchernev, Anastasiya Atanasova Chokoeva, Uwe Wollina, Torello Lotti, Barbara B Wilson
A 67-year-old woman presented with a firm plaque in the perineal region, 16 months after diagnosis of a high-grade basaloid squamous cell carcinoma of the vagina and treatment by external beam radiation therapy and vaginal cuff brachytherapy. The differential diagnosis included radiation-induced morphea, radiation dermatitis, or, possibly, radiation-induced lichen sclerosus. Biopsy findings, including special staining, confirmed the diagnosis of radiation-induced lichen sclerosus. To our knowledge, this is the first report of radiation-induced lichen sclerosus of the vulvar region...
November 10, 2016: Wiener Medizinische Wochenschrift
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