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https://www.readbyqxmd.com/read/29031200/oleanolic-acid-methyl-ester-a-novel-cytotoxic-mitocan-induces-cell-cycle-arrest-and-ros-mediated-cell-death-in-castration-resistant-prostate-cancer-pc-3-cells
#1
Noha Abdelmageed, Samy A F Morad, Ashraf A Elghoneimy, Tatiana Syrovets, Thomas Simmet, Hesham El-Zorba, Hossney A El-Banna, Myles Cabot, Magdy I Abdel-Aziz
Oleanolic acid derivatives exhibit potent anticancer activities against numerous types of cancer. However, the antitumor activity of oleanolic acid methylester (OAME), an oleanolic acid derivative, against prostate cancer has not been studied. Hence, the present work was conducted to study the anticancer activities of OAME. Viability assay showed that treatment of cancer cells with OAME induced a significant cell death in concentration- and time-dependent manner. Of note, OAME displayed a selective cytotoxicity against cancer cells compared to normal epithelial cells...
October 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29031197/mitochondrial-dysfunction-is-responsible-for-fatty-acid-synthase-inhibition-induced-apoptosis-in-breast-cancer-cells-by-pdpamn
#2
Qiang Wang, Xia Du, Bingjie Zhou, Jing Li, Wenlong Lu, Qiuyun Chen, Jing Gao
Targeting cellular metabolism is becoming a hallmark to overcome drug resistance in breast cancer treatment. Activation of fatty acid synthase (FASN) has been shown to promote breast cancer cell growth. However, there is no concrete report underlying the mechanism associated with mitochondrial dysfunction in relation to fatty acid synthase inhibition-induced apoptosis in breast cancer cells. The current study is aimed at exploring the effect of the novel manganese (Mn) complex, labeled as PdpaMn, on lipid metabolism and mitochondrial function in breast cancer cells...
October 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29031091/hexavalent-chromium-removal-by-multilayer-membrane-assisted-by-photocatalytic-couple-nanoparticle-from-both-permeate-and-retentate
#3
Maryamossadat Kazemi, Mohsen Jahanshahi, Majid Peyravi
In this study, a novel photocatalytic thin film nanocomposite (TFC) membrane was prepared for removal of hexavalent chromium (Cr(VI)) from aqueous solution. In this regards, a TFC membrane was modified by a layer of chitosan as an adsorbent and then was coated with a layer of synthesized photocatalytic nanoscale zerovalent iron@titanium dioxide (nZVI@TiO2) nanoparticles via layer-by-layer (LBL) technology. Prepared membranes were characterized by X-ray diffraction (XRD), energy dispersive X-ray spectroscopy (EDX), field emission scanning electron microscopy (FESEM), atomic force microscopy (AFM) and contact angle analysis...
October 3, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29031076/synthesis-and-evaluation-of-new-pyridyl-pyrazinyl-thiourea-derivatives-neuroprotection-against-amyloid-%C3%AE-induced-toxicity
#4
Jung-Eun Park, Ahmed Elkamhawy, Ahmed H E Hassan, Ae Nim Pae, Jiyoun Lee, Sora Paik, Beoung-Geon Park, Eun Joo Roh
Herein, we report synthesis and evaluation of new twenty six small molecules against β amyloid (Aβ)-induced opening of mitochondrial permeability transition pore (mPTP) using JC-1 assay which measures the change of mitochondrial membrane potential (ΔΨm). The neuroprotective effect of seventeen compounds against Aβ-induced mPTP opening was superior to that of the standard Cyclosporin A (CsA). Fifteen derivatives eliciting increased green to red fluorescence percentage less than 40.0% were evaluated for their impact on ATP production, cell viability and neuroprotection against Aβ-induced neuronal cell death...
September 22, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29031071/discovery-of-thienopyrrolotriazine-derivatives-to-protect-mitochondrial-function-against-a%C3%AE-induced-neurotoxicity
#5
TaeHun Kim, Woo Seung Son, Mohammad Neaz Morshed, Ashwini M Londhe, Seo Yun Jung, Jong-Hyun Park, Woo-Kyu Park, Sang Min Lim, Ki Duk Park, Sung Jin Cho, Kyu-Sung Jeong, Jiyoun Lee, Ae Nim Pae
Recovery of mitochondrial dysfunction has gained increasing attention as an alternative therapeutic strategy for Alzheimer's disease (AD). Recent studies suggested that the 18 kDa mitochondrial translocator protein (TSPO) has the potential to serve as a drug target for the treatment of AD. In this study, we generated a structure-based pharmacophore model and virtually screened a commercial library, identifying SVH07 as a virtual hit, which contained a tricyclic core structure, thieno[2',3':4,5]pyrrolo[1,2-d][1,2,4]triazine group...
September 21, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29029330/the-association-between-omega-3-fatty-acid-biomarkers-and-inflammatory-arthritis-in-an-anti-citrullinated-protein-antibody-positive-population
#6
Ryan W Gan, Elizabeth A Bemis, M Kristen Demoruelle, Christopher C Striebich, Stacey Brake, Marie L Feser, LauraKay Moss, Michael Clare-Salzler, V Michael Holers, Kevin D Deane, Jill M Norris
Objectives: Higher circulating omega-3 fatty acids (n-3 FAs) are associated with a lower prevalence of anti-CCP antibodies and RF in subjects without RA. We examined whether, in anti-CCP+ subjects, n-3 FAs also play a role in development of inflammatory arthritis (IA). Methods: At Colorado-based health fairs from 2008 to 2014, participants without a previous diagnosis of RA who were anti-CCP3+ (n = 47) were recruited into a follow-up study; symptom assessments and joint examinations were conducted every 6 months for the determination of IA...
October 4, 2017: Rheumatology
https://www.readbyqxmd.com/read/29029329/a-new-anthropophilic-species-of-simulium-trichodagmia-diptera-simuliidae-from-amazonia-morphology-chromosomes-and-dna-sequences
#7
Jeane Marcelle Cavalcante Do Nascimento, Neusa Hamada, Vanderly Andrade-Souza, Peter H Adler
The black fly Simulium (Trichodagmia) hirtipupa Lutz (Diptera: Simuliidae) is widely distributed in southern Brazil, with one report from Amapá state in the northern region of Brazilian Amazonia. Morphological comparison of northern and southern populations revealed differences in all life stages, corroborated by chromosomal and molecular analyses, and indicated that the population previously identified as S. hirtipupa from Amapá state represents an undescribed species. This new species is described based on all life stages above the egg, and its chromosomal and molecular divergence from S...
October 2, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/29029322/a-dynamic-mathematical-model-of-bile-acid-clearance-in-heparg-cells
#8
Daniel Kaschek, Ahmad Sharanek, André Guillouzo, Jens Timmer, Richard J Weaver
A dynamic model based on ordinary differential equations that describes uptake, basolateral and canalicular export of taurocholic acid in human HepaRG cells is presented. The highly reproducible inter-assay experimental data were used to reliably estimate model parameters. Primary human hepatocytes were similarly evaluated to establish a mathematical model, but with notably higher inter-assay differences in taurocholic acid clearance and bile canaliculi dynamics. By use of the HepaRG cell line, the simultaneous taurocholic acid clearance associated to basolateral uptake, canalicular and sinusoidal efflux, was predicted...
September 18, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29029277/mir-122-release-in-exosomes-precedes-overt-tolvaptan-induced-necrosis-in-a-primary-human-hepatocyte-micropatterned-coculture-model
#9
Merrie Mosedale, J Scott Eaddy, O Joseph Trask, Natalie S Holman, Kristina K Wolf, Edward LeCluyse, Brenton R Ware, Salman R Khetani, Jingtao Lu, William J Brock, Sharin E Roth, Paul B Watkins
Idiosyncratic drug-induced liver injury (IDILI) is thought to often result from an adaptive immune attack on the liver. However, it has been proposed that the cascade of events culminating in an adaptive immune response begins with drug-induced hepatocyte stress, release of exosomal danger signals, and innate immune activation, all of which may occur in the absence of significant hepatocelluar death. A micropatterned coculture model (HepatoPac®) was used to explore the possibility that changes in exosome content precede overt necrosis in response to the IDILI drug tolvaptan...
September 28, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29029205/transcriptome-analysis-of-the-triatoma-infestans-hemiptera-reduviidae-integument
#10
Gustavo M Calderón-Fernández, Débora E Moriconi, Andrea B Dulbecco, M Patricia Juárez
The insect integument, formed by the cuticle and the underlying epidermis, is essential for insect fitness, regulation of lipid biosynthesis and storage, insect growth and feeding, together with development progress. Its participation in insecticide resistance has also been outlined. Triatoma infestans Klug (Hemiptera: Reduviidae) is one of the major vectors of Chagas disease in South America; however, genomic data are scarce. In this study, we performed a transcriptome analysis of the nymph integument in order to identify which genes are expressed and their putative role...
September 27, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/29029126/hyalomma-dromedarii-acari-ixodidae-salivary-gland-extract-inhibits-angiogenesis-and-exhibits-in-vitro-antitumor-effects
#11
Chaima Bensaoud, Zaineb Abdelkafi-Koubaa, Hazem Ben Mabrouk, Maram Morjen, Issam Hmila, Adel Rhim, Mohamed El Ayeb, Naziha Marrakchi, Ali Bouattour, Youmna M'ghirbi
Hard ticks (Acari: Ixodidae) are blood-sucking ectoparasites characterized by the extended period of their attachment to their host. To access their bloodmeal, ticks secrete saliva containing a range of molecules that target the host's inflammation, immune system, and hemostatic components. Some of these molecules reportedly possess antiangiogenic and antitumor properties. The present study describes our investigation, the first of its kind, of the antiangiogenic and antitumoral effects of the Hyalomma dromedarii Koch, 1844 (Acari: Ixodidae), salivary gland extract (SGE), which inhibited the adhesion and migration of Human Umbilical Vein Endothelial Cells (HUVECs) in a dose-dependent manner, as well as angiogenesis in the Chick Chorioallantoic Membrane model...
September 25, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/29029044/enhanced-killing-of-escherichia-coli-using-a-combination-of-polyhexamethylene-biguanide-hydrochloride-and-1-bromo-3-chloro-5-5-dimethylimidazolidine-2-4-dione
#12
Wan Huai, Zhirui Deng, Wenshu Lin, Qin Chen
The bactericidal activities of polyhexamethylene biguanide hydrochloride (PHMB), 1-bromo-3-chloro-5,5-dimethylimidazolidine-2,4-dione (BCDMH), and the combination of the two (designated as PB) were compared using Escherichia coli as the test organism. PB exhibited strong bactericidal activity: 10 mg/L PHMB combined with 8 mg/L BCDMH resulted in approximately 5.74 log10 reduction (LR), whereby 320 mg/L PHMB or 20 mg/L BCDMH was about 5.53 and 6.56 LR, respectively. Analyses using scanning electron microscopy, flow cytometry, and atomic absorption spectroscopy indicated that PB, PHMB, and BCDMH disrupted cell membranes and changed membrane structure and permeability, resulting in the leakage of intracellular soluble proteins and ions...
October 4, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/29029020/the-endometrial-polarity-paradox-differential-regulation-of-polarity-within-secretory-phase-human-endometrium
#13
Sarah Whitby, Lois A Salamonsen, Jemma Evans
A major cause of infertility in normal and assisted reproduction cycles is failure of the endometrium to undergo appropriate changes during the secretory phase of the menstrual cycle as it acquires receptivity for an implanting blastocyst. Current dogma states that loss of epithelial polarity in the luminal epithelial cells, the point of first contact between maternal endometrium and blastocyst, may facilitate embryo implantation. Loss of polarity is likely an important change during the secretory phase to overcome mutual repulsion between otherwise polarised epithelial surfaces...
September 29, 2017: Endocrinology
https://www.readbyqxmd.com/read/29028853/impact-of-sex-age-and-season-on-sinus-membrane-thickness
#14
Nouf Zimmo, Angel Insua, Khaled Sinjab, Hsun-Liang Chan, Lujain Shaikh, Hom-Lay Wang
PURPOSE: Sinus membrane thickness has been associated with the incidence of membrane perforation during the sinus elevation procedure. Understanding the sinus membrane thickness is essential for prevention of this specific surgical complication. Therefore, the aim of this retrospective study was to investigate the impact of sex, age, and season on the membrane thickness. MATERIALS AND METHODS: The charts of 144 healthy patients were included in the study. Cone beam computed tomography (CBCT) images from these patients were analyzed to determine the sinus membrane thickness in the coronal and sagittal views...
October 13, 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/29028848/the-stability-of-augmented-bone-between-two-different-membranes-used-for-guided-bone-regeneration-simultaneous-with-dental-implant-placement-in-the-esthetic-zone
#15
Sirida Arunjaroensuk, Soontra Panmekiate, Atiphan Pimkhaokham
PURPOSE: This randomized controlled clinical trial compared the stability of augmented bone between a synthetic resorbable membrane and a collagen resorbable membrane with guided bone regeneration (GBR) simultaneous with dental implant placement in the esthetic zone in terms of facial bone thickness. MATERIALS AND METHODS: A total of 60 dental implants from patients requiring implant placement with simultaneous GBR in the esthetic zone were equally allocated to the test group or control group by block randomization...
October 13, 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/29028845/analysis-of-cell-cycle-parameters-during-the-transition-from-unhindered-growth-to-ribosomal-and-translational-stress-conditions
#16
Md Shamsuzzaman, Ananth Bommakanti, Aviva Zapinsky, Nusrat Rahman, Clarence Pascual, Lasse Lindahl
Abrogation of ribosome synthesis (ribosomal stress) leads to cell cycle arrest. However, the immediate cell response to cessation of ribosome formation and the transition from normal cell proliferation to cell cycle arrest have not been characterized. Furthermore, there are conflicting conclusions about whether cells are arrested in G2/M or G1, and whether the cause is dismantling ribosomal assembly per se, or the ensuing decreased number of translating ribosomes. To address these questions, we have compared the time kinetics of key cell cycle parameters after inhibiting ribosome formation or function in Saccharomyces cerevisiae...
2017: PloS One
https://www.readbyqxmd.com/read/29028820/a-c-terminal-motif-contributes-to-the-plasma-membrane-localization-of-arabidopsis-stp-transporters
#17
Kohji Yamada, Yuriko Osakabe, Kazuko Yamaguchi-Shinozaki
Membrane trafficking is highly organized to maintain cellular homeostasis in any organisms. Membrane-embedded transporters are targeted to various organelles to execute appropriate partition and allocation of their substrates, such as ions or sugars. To ensure the fidelity of targeting and sorting, membrane proteins including transporters have sorting signals that specify the subcellular destination and the trafficking pathway by which the destination is to be reached. Here, we have identified a novel sorting signal (called the tri-aromatic motif) which contains three aromatic residues, two tryptophans and one histidine, for the plasma membrane localization of sugar transporters in the STP family in Arabidopsis...
2017: PloS One
https://www.readbyqxmd.com/read/29028787/relationship-between-pd-l1-expression-and-cd8-t-cell-immune-responses-in-hepatocellular-carcinoma
#18
Chun-Yu Huang, Ying Wang, Guang-Yu Luo, Feng Han, Yong-Qiang Li, Zhong-Guo Zhou, Guo-Liang Xu
As PD-1/PD-L1 immune checkpoint inhibitors exhibited promising clinical outcomes in various types of solid tumors, PD-1/PD-L1 blockades have been explored for the treatment of hepatocellular carcinoma (HCC). However, the association of PD-L1 with antitumor immunoregulation is not clearly defined in HCC. Here, we evaluated the characteristics of PD-L1 expression, CD8 T-cell infiltration and their relationship in HCC. A total of 411 resected tumor specimens from HCC patients were immunostained for PD-L1 and CD8...
November 2017: Journal of Immunotherapy
https://www.readbyqxmd.com/read/29028767/prostate-specific-membrane-antigen-guided-salvage-lymph-node-dissection-in-recurrent-prostate-cancer-a-novel-technology-to-detect-lymph-node-metastases
#19
Tobias Maurer, Jürgen E Gschwend, Matthias Eiber
PURPOSE OF REVIEW: With Gallium (Ga)-prostate-specific membrane antigen (PSMA) PET/computed tomography (CT) as emerging imaging technique offering superior detection rates in biochemical recurrent prostate cancer, salvage lymph node dissection has gained increasing interest in localized oligometastatic prostate cancer. Currently, PSMA-targeting small molecules cannot only be linked to positron-emitting isotopes for imaging but also be labelled with γ-radiation emitting isotopes. These modified PSMA agents are evaluated for intraoperative guidance for resection of metastatic lymph nodes...
October 11, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/29028609/daunorubicin-and-doxorubicin-molecular-interplay-with-2d-membrane-models
#20
Ana Catarina Alves, Cláudia Nunes, José Lima, Salette Reis
The anthracyclines daunorubicin and doxorubicin are widely used antineoplastic agents due to their therapeutic activity against a broad variety of human cancers. Although, the classical model to explain anthracyclines' cytotoxicity has been based in the direct interference with nucleic acid function, evidence suggests that the plasma membrane is also involved in the drug's mechanism of action. In this work, the interaction of these drugs with two-dimensional membrane models were studied in order to gain further insights at the molecular level regarding anthracyclines membrane interactions...
October 3, 2017: Colloids and Surfaces. B, Biointerfaces
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