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https://www.readbyqxmd.com/read/29454269/biological-effects-of-four-iron-containing-nanoremediation-materials-on-the-green-alga-chlamydomonas-sp
#1
Nhung H A Nguyen, Nadia R Von Moos, Vera I Slaveykova, Katrin Mackenzie, Rainer U Meckenstock, Silke Thűmmler, Julian Bosch, Alena Ševců
As nanoremediation strategies for in-situ groundwater treatment extend beyond nanoiron-based applications to adsorption and oxidation, ecotoxicological evaluations of newly developed materials are required. The biological effects of four new materials with different iron (Fe) speciations ([i] FerMEG12 - pristine flake-like milled Fe(0) nanoparticles (nZVI), [ii] Carbo-Iron ® - Fe(0)-nanoclusters containing activated carbon (AC) composite, [iii] Trap-Ox® Fe-BEA35 (Fe-zeolite) - Fe-doped zeolite, and [iv] Nano-Goethite - 'pure' FeOOH) were studied using the unicellular green alga Chlamydomonas sp...
February 14, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29454246/screening-of-physicochemical-treatment-processes-for-reducing-toxicity-of-hair-care-products-wastewaters
#2
Elisa Dias de Melo, Ann Mounteer, Eduarda Reis, Ellen Costa, Alana Vilete
Toxicity reduction in wastewaters from small hair care products manufacturing companies using coagulation/flocculation/sedimentation or flotation, membrane separation and powdered activated charcoal adsorption was evaluated. Raw wastewater composition varied widely within and especially between companies, but all exhibited high acute toxicity to Daphnia similis (EC(I)50; 48 h < 0.02-0.33%). Coagulation with aluminum sulfate and polyaluminum chloride aided by cationic or anionic polymers, as well as filtration on ultra (UF) and nanofiltration (NF) membranes efficiently removed turbidity (>99%) and oil and grease (>99%) and all treated samples exhibited similar dissolved organic matter contents...
February 14, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29454239/phenol-separation-from-phenol-laden-saline-wastewater-by-membrane-aromatic-recovery-system-like-membrane-contactor-using-superhydrophobic-organophilic-electrospun-pdms-pmma-membrane
#3
Long-Fei Ren, Mister Adeel, Jun Li, Cong Xu, Zheng Xu, Xiaofan Zhang, Jiahui Shao, Yiliang He
Phenol recovery from phenol-laden saline wastewater plays an important role in the waste reclamation and pollution control. A membrane aromatic recovery system-like membrane contactor (MARS-like membrane contactor) was set up in this study using electrospun polydimethylsiloxane/polymethyl methacrylate (PDMS/PMMA) membrane with 0.0048 m 2 effective area to separate phenol from saline wastewater. Phenol and water contact angles of 0° and 162° were achieved on this membrane surface simultaneously, indicating its potential in the separation of phenol and water-soluble salt...
February 10, 2018: Water Research
https://www.readbyqxmd.com/read/29454159/an-aligned-porous-electrospun-fibrous-membrane-with-controlled-drug-delivery-an-efficient-strategy-to-accelerate-diabetic-wound-healing-with-improved-angiogenesis
#4
Xiaozhi Ren, Yiming Han, Jie Wang, Yuqi Jiang, Zhengfang Yi, He Xu, Qinfei Ke
A chronic wound in diabetic patients is usually characterized by poor angiogenesis and delayed wound closure. The exploration of efficient strategy to significantly improve angiogenesis in the diabetic wound bed and thereby accelerate wound healing is still a significant challenge. Herein, we reported a kind of aligned porous poly (L-lactic acid) (PLLA) electrospun fibrous membranes containing dimethyloxalylglycine (DMOG)-loaded mesoporous silica nanoparticles (DS) for diabetic wound healing. The PLLA electrospun fibers aligned in a single direction and there were ellipse-shaped nano-pores in situ generated onto the surface of fibers, while the DS were well distributed in the fibers and the DMOG as well as Si ion could be controlled released from the nanopores on the fibers...
February 14, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29454148/-68-ga-galmydar-biodistribution-and-radiation-dosimetry-studies-in-rodents
#5
Jothilingam Sivapackiam, Richard Laforest, Vijay Sharma
INTRODUCTION: 68 Ga-Galmydar is an avid transport substrate of ABCB1 (P-Glycoprotein; 170kDa plasma membrane protein), breast cancer resistance protein (BCRP; ABCG2; 72kDa), penetrates human epidermal carcinoma (KB3-1), breast cancer (MCF7), embryonic kidney (HEK 293) tumor cells and rat cardiomyoblasts, and localizes within the mitochondria of tumor and myocardium cells. 68 Ga-Galmydar excretes from blood pool quickly, and shows stable retention within rat myocardium in vivo for extended periods, therefore, the agent shows potential to enable myocardial perfusion imaging...
December 1, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/29454091/anlotinib-inhibits-angiogenesis-via-suppressing-the-activation-of-vegfr2-pdgfr%C3%AE-and-fgfr1
#6
Binyan Lin, Xiuming Song, Dawei Yang, Dongsheng Bai, Yuyuan Yao, Na Lu
Tumor cells recruit vascular endothelial cells and circulating endothelial progenitor cells to form new vessels to support their own growth and metastasis. VEGF, PDGF-BB and FGF-2 are three major pro-angiogenic factors and applied to promote angiogenesis. In this research, we demonstrated that anlotinib, a potent multi-tyrosine kinases inhibitor (TKI), showed a significant inhibitory effect on VEGF/PDGF-BB/FGF-2-induced angiogenesis in vitro and in vivo. Wound healing assay, chamber directional migration assay and tube formation assay indicated that anlotinib inhibited VEGF/PDGF-BB/FGF-2-induced cell migration and formation of capillary-like tubes in endothelial cells...
February 14, 2018: Gene
https://www.readbyqxmd.com/read/29454025/early-alteration-of-distribution-and-activity-of-hippocampal-type-1-cannabinoid-receptor-in-alzheimer-s-disease-like-mice-overexpressing-the-human-mutant-amyloid-precursor-protein
#7
Mauro Maccarrone, Antonio Totaro, Alessandro Leuti, Giacomo Giacovazzo, Lucia Scipioni, Dalila Mango, Roberto Coccurello, Robert Nisticò, Sergio Oddi
Besides its involvement in Alzheimer's disease (AD) as precursor of the neurotoxic amyloid peptides, the pathophysiological impact of brain accumulation of amyloid precursor protein (APP) is not yet well understood. Recent studies reported that APP interacts with other membrane proteins, including G protein coupled receptors, affecting their biological functions. Here, we focused on the study of the potential impact of human mutant APP on expression, distribution and activity of type-1 cannabinoid (CB 1 ) receptor in the hippocampus of Tg2576 mice, an AD-like mice model...
February 14, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29453988/silencing-calreticulin-gene-might-protect-cardiomyocytes-from-angiotensin-ii-induced-apoptosis
#8
Wen Zhang, Zhiyue Liu, Yanmei Zhang, Qinxue Bao, Wenchao Wu, He Huang, Xiaojing Liu
AIMS: Calreticulin (CRT), as a chaperone, contributes to protein folding and quality control cycle. CRT is an important factor regulating Ca 2+ that participates in cell apoptosis. However, the function of CRT in the heart is still controversial. Therefore, we aimed to investigate the potential role of CRT in angiotensin II-induced cardiomyocytes apoptosis. MAIN METHODS: Primary cultured neonatal cardiomyocytes were stimulated with angiotensin II to induce the apoptosis...
February 14, 2018: Life Sciences
https://www.readbyqxmd.com/read/29453885/bacterial-neuraminidase-mediated-erythrocyte-desialylation-provokes-cell-surface-aminophospholipid-exposure
#9
Syed M Qadri, David A Donkor, Ishac Nazy, Donald R Branch, William P Sheffield
BACKGROUND: Surface desialylation is associated with erythrocyte aging and mediates phagocytic recognition and clearance of senescent erythrocytes. Neuraminidases, a family of glycohydrolytic enzymes, cleave the glycosidic linkages between sialic acid and mucopolysaccharides and have previously been implicated in erythrocyte dysfunction associated with sepsis. Erythrocytes in septic patients further display a phenotype of accelerated eryptosis characterized by membrane phospholipid scrambling resulting in phosphatidylserine (PS) externalization...
February 17, 2018: European Journal of Haematology
https://www.readbyqxmd.com/read/29453877/significance-of-mitochondria-on-cardiometabolic-syndromes
#10
REVIEW
Nair Anupama, G Sindhu, K G Raghu
Metabolic syndromes (MS) are a cluster of disorders like obesity, hypertension, dyslipidemia, and diabetes. Cardiometabolic syndrome (CMS), a branch of MS, is a group of diseases affecting cardiovascular, renal, metabolic, prothrombotic and inflammatory abnormalities due to defects in energy metabolism. Since the emergence of molecular biology and the discovery of pathogenic mitochondrial DNA defect in the 1980s, research advances has revealed a number of common human disease involving mitochondrial dysfunction...
February 17, 2018: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/29453850/the-role-of-the-immune-system-in-kidney-disease
#11
REVIEW
Josefine Tecklenborg, David Clayton, Stefan Siebert, Shana M Coley
The immune system and the kidneys are closely linked. In health the kidneys contribute to immune homeostasis, while components of the immune system mediate many acute forms of renal disease and play a central role in progression of chronic kidney disease. A dysregulated immune system can have either direct or indirect renal effects. Direct immune-mediated kidney diseases are usually a consequence of autoantibodies directed against a constituent renal antigen, such as collagen IV in anti-glomerular basement membrane disease...
February 17, 2018: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29453806/cq-sensitizes-human-pancreatic-cancer-cells-to-gemcitabine-through-the-lysosomal-apoptotic-pathway-via-reactive-oxygen-species
#12
Zhiping Fu, Cheng Xi, Jie Kuang, Haoran Feng, Lingxie Chen, Juyong Liang, Xiaonan Shen, Stanley Yuen, Peng Chenghong, Shen Baiyong, Jin Zhijian, Weihua Qiu
As an established anti-cancer drug, gemcitabine (GEM) is an effective systemic treatment for advanced pancreatic cancer (PC). However, little is known about the potential effectors that may modify tumour cell sensitivity towards GEM. Autophagy, as a physiological cellular mechanism, is involved in both cell survival and cell death. In this study, we found that exposure to GEM induced a significant increase in autophagy in a dose-dependent manner in PANC-1 and BxPC-3 cells. Inhibition of autophagy by chloroquine (CQ) and ATG7 siRNA increased GEM-induced cytotoxicity, and CQ was more effective than ATG7 siRNA...
February 17, 2018: Molecular Oncology
https://www.readbyqxmd.com/read/29453802/introduction-to-the-special-issue-on-membrane-trafficking-in-neurons
#13
EDITORIAL
Huaye Zhang, Bettina Winckler, Qian Cai
No abstract text is available yet for this article.
March 2018: Developmental Neurobiology
https://www.readbyqxmd.com/read/29453780/bone-conditioned-medium-modulates-the-osteoconductive-properties-of-collagen-membranes-in-a-rat-calvaria-defect-model
#14
Ulrike Kuchler, Tina Rybaczek, Toni Dobask, Patrick Heimel, Stefan Tangl, Jessica Klehm, Matthias Menzel, Reinhard Gruber
OBJECTIVES: Collagen membranes are not limited to be occlusive barriers as they actively support bone regeneration. However, the impact of bone-derived growth factors on their osteoconductive competence has not been examined. METHODS: Twenty adult Sprague Dawley rats were included in the study. Calvaria defects with a diameter of five millimeter were created. The defect was covered with one layer of a collagen membrane previously soaked in conditioned medium of porcine bone chips or in culture medium alone...
February 16, 2018: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/29453727/floating-flap-of-internal-limiting-membrane-in-myopic-macular-hole-surgery
#15
Kenji Yamashiro, Eri Kinoshita-Nakano, Toru Ota, Yoko Jingami, Isao Nakata, Hisako Hayashi
PURPOSE: To evaluate the surgical results of macular hole (MH) in patients with high myopia treated with pars plana vitrectomy (PPV) leaving the internal limiting membrane (ILM) flap floating in vitreous fluid at the edge of the MH. METHODS: Nine highly myopic eyes with MH of nine consecutive patients who underwent PPV were retrospectively evaluated. Three eyes were accompanied by retinal detachment (RD). ILM peeling was performed around the MH and some part of the ILM flap was left attached to the edge of the MH...
February 16, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29453718/cfd-simulation-of-copper-ii-extraction-with-tfa-in-non-dispersive-hollow-fiber-membrane-contactors
#16
Amir Muhammad, Mohammad Younas, Mashallah Rezakazemi
This study presents computational fluid dynamics (CFD) simulation of dispersion-free liquid-liquid extraction of copper(II) with trifluoroacetylacetone (TFA) in hollow fiber membrane contactor (HFMC). Mass and momentum balance Navier-Stokes equations were coupled to address the transport of copper(II) solute across membrane contactor. Model equations were simulated using COMSOL Multiphysics™. The simulation was run to study the detailed concentration distribution of copper(II) and to investigate the effects of various parameters like membrane characteristics, partition coefficient, and flow configuration on extraction efficiency...
January 27, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29453682/persistent-pulmonary-hypertension-and-histologic-chorioamnionitis-in-preterm-infants-controlled-study
#17
N Katz, Y Bar-Or, A Raucher-Sterrnfeld, A Tamir, D Kohelet
Persistent pulmonary hypertension (PPHN) of the newborn is one of the most challenging acute disorders of postnatal transition with substantial morbidity and mortality. The aim of the study was to find if there is an association between persistent pulmonary hypertension and histologic chorioamnionitis in preterm infants. 27 preterm infants with echocardiographic evidence of PPHN within the first 3 days of life were eligible for the study. A matched control group of 27 patients was chosen according to gestational age, date of birth, and gender...
February 16, 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29453648/supplemental-diagnosis-of-gyrodactylus-fairporti-van-cleave-1921-monogenea-from-1-month-old-black-bullhead-ameiurus-melas-in-riverside-pools-in-wisconsin
#18
Eric Leis, Russell Easy, David Cone
Samples of Gyrodactylus fairporti Van Cleave, 1921 from young-of-the-year black bullhead (Ameiurus melas) stranded in riverside pools of the Black River (La Crosse County,) WI, USA, are used to supplement the species diagnosis, including new details on the marginal hook sickles, the male copulatory organ (MCO), and 18S rRNA gene sequence data. The anchors of G. fairporti are relatively long and thin, 58.2 ± 1.2 μm in length; roots 15.5 ± 1.0 μm; shaft 38.1 ± 1.5 μm; point 31.3 ± 1.5 μm. The ventral bar is 19...
February 17, 2018: Parasitology Research
https://www.readbyqxmd.com/read/29453608/chemopreventive-action-of-imatinib-a-tyrosine-kinase-inhibitor-in-the-regulation-of-angiogenesis-and-apoptosis-in-rat-model-of-lung-cancer
#19
Kulvinder Kumar, Preety Ghanghas, S N Sanyal
The present study explored the events of angiogenesis and apoptosis in 7,12-dimethyl benz(a)anthracene (DMBA)-induced lung cancer in rat and its chemoprevention with Imatinib, a receptor tyrosine kinase inhibitor. Further, it includes lipopolysaccharide (LPS) mediating inflammation along with DMBA for the promotion of lung carcinogenesis. The animals received a single intratracheal instillation of DMBA (20 mg/kg body weight) in olive oil and LPS (0.6 mg/kg body weight) to induce tumors in 16 weeks. Besides morphology and histology of the lung tissues, RT-PCR, western blots, and immunofluorescence were performed for the expression of apoptotic and angiogenic proteins...
February 16, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29453576/monitoring-the-integrity-of-the-blood-testis-barrier-btb-an-in-vivo-assay
#20
Haiqi Chen, Wing-Yee Lui, Dolores D Mruk, Xiang Xiao, Renshan Ge, Qingquan Lian, Will M Lee, Bruno Silvestrini, C Yan Cheng
The blood-testis barrier is a unique ultrastructure in the mammalian testis, located near the basement membrane of the seminiferous tubule that segregates the seminiferous epithelium into the basal and the adluminal (apical) compartment. Besides restricting paracellular and transcellular passage of biomolecules (e.g., paracrine factors, hormones), water, electrolytes, and other substances including toxicants and/or drugs to enter the adluminal compartment of the epithelium, the BTB is an important ultrastructure that supports spermatogenesis...
2018: Methods in Molecular Biology
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