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https://www.readbyqxmd.com/read/28823106/mitochondrial-outer-membrane-permeabilization-a-focus-on-the-role-of-mitochondrial-membrane-structural-organization
#1
REVIEW
Siti Haji Suhaili, Hamed Karimian, Matthew Stellato, Tzong-Hsien Lee, Marie-Isabel Aguilar
Apoptosis is important in regulating cell death turnover and is mediated by the intrinsic and death receptor-based extrinsic pathways which converge at the mitochondrial outer membrane (MOM) leading to mitochondrial outer membrane permeabilization (MOMP). MOMP results in the release of apoptotic proteins that further activate the downstream pathway of apoptosis. Thus, tight regulation of MOMP is crucial in controlling apoptosis, and a lack of control may lead to tissue and organ malformation and the development of cancers...
August 19, 2017: Biophysical Reviews
https://www.readbyqxmd.com/read/28823080/the-many-faces-and-phases-of-ceramide-and-sphingomyelin-ii-binary-mixtures
#2
REVIEW
María Laura Fanani, Bruno Maggio
A rather widespread idea on the functional importance of sphingolipids in cell membranes refers to the occurrence of ordered domains enriched in sphingomyelin and ceramide that are largely assumed to exist irrespective of the type of N-acyl chain in the sphingolipid. Ceramides and sphingomyelins are the simplest kind of two-chained sphingolipids and show a variety of species, depending on the fatty acyl chain length, hydroxylation, and unsaturation. Abundant evidences have shown that variations of the N-acyl chain length in ceramides and sphingomyelins markedly affect their phase state, interfacial elasticity, surface topography, electrostatics, and miscibility, and that even the usually conceived "condensed" sphingolipids and many of their mixtures may exhibit liquid-like expanded states...
August 19, 2017: Biophysical Reviews
https://www.readbyqxmd.com/read/28823068/stress-affects-surface-glycoconjugates-of-the-rat-endometrium-at-the-time-of-implantation
#3
Elham Aliabadi, Zohreh Makoolati, Tahereh Talaei-Khozani, Fakhreddin Mesbah Ardekani
One of the treatments to infertility is In Vitro Fertilization (IVF). In the course of IVF, fertilization rate can be improved through stress reduction. Probably one of the causes of low outcome of IVF is changes in uterine glycoconjugates that are first site of contact between blastocyst and uterus, due to stress, e.g., stress of injection. Thus, the study of the injectional stress effects on implantation period is very important to improve the outcome of IVF. Sixteen mature female rats were divided to experimental and control groups...
August 19, 2017: Glycoconjugate Journal
https://www.readbyqxmd.com/read/28823034/effect-of-pristine-and-functionalized-single-and-multi-walled-carbon-nanotubes-on-co2-separation-of-mixed-matrix-membranes-based-on-polymers-of-intrinsic-microporosity-pim-1-a-molecular-dynamics-simulation-study
#4
Karim Golzar, Hamid Modarress, Sepideh Amjad-Iranagh
Molecular dynamics (MD) and grand canonical Monte Carlo (GCMC) simulations were conducted to investigate the transport properties of carbon dioxide, methane, nitrogen, and oxygen through pure and mixed matrix membranes (MMMs) based on polymers of intrinsic microporosity (PIM-1). For this purpose, first, 0.5 to 3 wt% of pristine single-walled carbon nanotube (p-SWCNT) and multi-walled carbon nanotube (p-MWCNT) were embedded into the pure PIM-1, and then for better dispersion of CNT particles into the polymer matrix and to improve the performance of the resulting MMMs, polyethylene glycol (PEG) functionalized SWCNT and MWCNT (f-SWCNT and f-MWCNT, respectively) were loaded...
August 19, 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28823021/control-by-low-levels-of-calcium-of-mammalian-cell-membrane-electropermeabilization
#5
Ciobanu Florin, Golzio Muriel, Kovacs Eugenia, Teissié Justin
Electric pulses, when applied to a cell suspension, induce a reversible permeabilization of the plasma membrane. This permeabilized state is a long-lived process (minutes). The biophysical molecular mechanisms supporting the membrane reorganization associated to its permeabilization remain poorly understood. Modeling the transmembrane structures as toroidal lipidic pores cannot explain why they are long-lived and why their resealing is under the control of the ATP level. Our results describe the effect of the level of free Calcium ions...
August 20, 2017: Journal of Membrane Biology
https://www.readbyqxmd.com/read/28823016/de-novo-synthesis-of-linoleic-acid-in-multiple-collembola-species
#6
Miriama Malcicka, Joachim Ruther, Jacintha Ellers
Many ecological interactions in communities take place between consumers and the organisms they feed on. Continuous surplus of specific nutritional compounds in the diet may lead to evolutionary changes in the metabolic capacity of the consumer, leaving the biosynthesis of such compounds prone to genetic decay and render organisms auxotrophic. A nutrient that is essential to many organisms is the unsaturated fatty acid, linoleic acid (LA; 18:2n-6), which is important in the maintenance of cell membrane fluidity and as a precursor for signaling molecules...
August 19, 2017: Journal of Chemical Ecology
https://www.readbyqxmd.com/read/28822994/glucagon-like-peptide-1-receptor-agonist-stimulates-mitochondrial-bioenergetics-in-human-adipocytes
#7
Joanna Góralska, Agnieszka Śliwa, Anna Gruca, Urszula Raźny, Monika Chojnacka, Anna Polus, Bogdan Solnica, Małgorzata Malczewska-Malec
Glucagon-like peptide 1 receptor agonists (GLP-1RAs) are relatively new pharmacological agents used to normalize glucose level in type 2 diabetes. Recently, GLP-1RAs have been approved for the treatment of obesity to reduce body weight in non-diabetic patients. The extra-pancre-atic effects of GLP-1RAs, as well as their molecular mechanism of action, are still poorly understood. Thus this study was aimed to verify the hypothesis that the mechanism of action of the GLP-1RAs involves mitochondria and that GLP-1RAs administration can improve mitochondrial functions...
August 19, 2017: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/28822986/insights-in-pathogenesis-of-multiple-sclerosis-nitric-oxide-may-induce-mitochondrial-dysfunction-of-oligodendrocytes
#8
Minghong Lan, Xiaoyi Tang, Jie Zhang, Zhongxiang Yao
Demyelinating diseases, such as multiple sclerosis (MS), are kinds of common diseases in the central nervous system (CNS), and originated from myelin loss and axonal damage. Oligodendrocyte dysfunction is the direct reason of demyelinating lesions in the CNS. Nitric oxide (NO) plays an important role in the pathological process of demyelinating diseases. Although the neurotoxicity of NO is more likely mediated by peroxynitrite rather than NO itself, NO can impair oligodendrocyte energy metabolism through mediating the damaging of mitochondrial DNA, mitochondrial membrane and mitochondrial respiratory chain complexes...
August 21, 2017: Reviews in the Neurosciences
https://www.readbyqxmd.com/read/28822950/enhancement-of-organic-matter-degradation-and-methane-gas-production-of-anaerobic-granular-sludge-by-degasification-of-dissolved-hydrogen-gas
#9
Hisashi Satoh, Wasala M K R T W Bandara, Manabu Sasakawa, Yoshihito Nakahara, Masahiro Takahashi, Satoshi Okabe
A hollow fiber degassing membrane (DM) was applied to enhance organic matter degradation and methane gas production of anaerobic granular sludge process by reducing the dissolved hydrogen gas (D-H2) concentration in the liquid phase. DM was installed in the bench-scale anaerobic granular sludge reactors and D-H2 was removed through DM using a vacuum pump. Degasification improved the organic matter degradation efficiency to 79% while the efficiency was 62% without degasification at 12,000mgL(-1) of the influent T-COD concentration...
August 9, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28822947/cell-metabolomics-reveals-the-neurotoxicity-mechanism-of-cadmium-in-pc12-cells
#10
Li Zong, Junpeng Xing, Shu Liu, Zhiqiang Liu, Fengrui Song
The heavy metals such as cadmium (Cd) can induce neurotoxicity. Extensive studies about the effects of Cd on human health have been reported, however, a systematic investigation on the molecular mechanisms of the effects of Cd on central nervous system is still needed. In this paper, the neuronal PC-12 cells were treated with a series of concentrations of CdCl2 for 48h. Then the cytotoxicity was evaluated by MTT (3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide) assay. The IC15 value (15% inhibiting concentration) was selected for further mechanism studies...
August 17, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28822916/wip1-dependent-modulation-of-macrophage-migration-and-phagocytosis
#11
Yiting Tang, Bing Pan, Xin Zhou, Kai Xiong, Qian Gao, Lei Huang, Ying Xia, Ming Shen, Shulin Yang, Honglin Liu, Tao Tan, Jianjie Ma, Xuehong Xu, Yulian Mu, Kui Li
Macrophage accumulation within the vascular wall is a hallmark of atherosclerosis. Controlling macrophage conversion into foam cells remains a major challenge for treatment of atherosclerotic diseases. Here, we show that Wip1, a member of the PP2C family of Ser/Thr protein phosphatases, modulates macrophage migration and phagocytosis associated with atherosclerotic plaque formation. Wip1 deficiency increases migratory and phagocytic activities of the macrophage under stress conditions. Enhanced migration of Wip1(-/-) macrophages is mediated by Rac1-GTPase and PI3K/AKT signalling pathways...
August 12, 2017: Redox Biology
https://www.readbyqxmd.com/read/28822891/comparative-toxicity-of-the-plasticizer-dibutyl-phthalate-to-two-freshwater-algae
#12
Shurui Gu, Hao Zheng, Qingqing Xu, Cuizhu Sun, Mei Shi, Zhenyu Wang, Fengmin Li
Phthalate esters (PAEs), a family of emerging environmental contaminants, have been frequently detected in soils and water. However, intensive studies on the toxicity of PAEs have focused on growth response of terrestrial and aquatic animals, while only limited attention has been paid to aquatic plants, especially phytoplankton, the primary producer in aquatic ecosystems. Therefore, the acute toxic effects and underlying mechanisms of dibutyl phthalate (DBP) at different concentrations (0-20mgL(-1)) on two typical freshwater algae (Scenedesmus obliquus and Chlorella pyrenoidosa) were investigated...
August 12, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28822878/in-vitro-method-to-evaluate-the-barrier-properties-of-medical-devices-for-cutaneous-use
#13
Antonella Casiraghi, Francesco Ranzini, Umberto M Musazzi, Silvia Franzè, Marisa Meloni, Paola Minghetti
Barrier creams (BC) are marketed as cosmetic products or locally-applied medical devices to protect skin against damages induced by chemical agents or physical insults. However, the determination of the BC effectiveness is still a matter of discussion at both the clinical and the regulatory level. In this context, this work aimed at the development of a reliable, reproducible and easy-to-perform experimental protocol for the evaluation of BC performances. Preliminarily, an in vivo method based on the measurement of trans-epidermal water loss had been matter of investigation and was discarded: it required too much time and was not robust and sensitive enough...
August 16, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28822864/tailoring-the-wettability-and-mechanical-properties-of-electrospun-poly-l-lactic-acid-poly-glycerol-sebacate-core-shell-membranes-for-biomedical-applications
#14
Yi Yan, Vitor Sencadas, Tiantian Jin, Xufeng Huang, Jun Chen, Dongbin Wei, Zhengyi Jiang
Tissue and biomedical engineering fields are in constant mutation and in searching for innovative processing techniques capable to tailor the material properties. In this work, poly(l-lactic acid) (PLLA) and elastomeric poly(glycerol sebacate) (PGS) were dissolved in the same solvents and electrospun together, in a single needle system. A core-shell structure where the hydrophilic PGS was placed onto the surface of the hydrophobic PLLA fibre was obtained for elastomeric concentrations up to 25wt%. It was found that the PLLA:PGS blends are immiscible and the blends present the melting temperatures of the individual polymers...
August 12, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28822845/triphenyl-phosphonium-coated-nano-quercetin-for-oral-delivery-neuroprotective-effects-in-attenuating-age-related-global-moderate-cerebral-ischemia-reperfusion-injury-in-rats
#15
Swarupa Ghosh, Sibani Sarkar, Somsubhra T Choudhury, Tirtha Ghosh, Nirmalendu Das
Cerebral ischemia-reperfusion is a classical example of reactive oxygen species (ROS) mediated acute damage to brain. Post-ischemic reperfusion induced oxygen free radicals production causes damage to brain cell mitochondria. Antioxidants like quercetin (Qc) have potentials to manage oxidative stress related pathophysiology. However low oral bioavailability and poor cell membrane permeability restricts its therapeutic efficacy. To overcome these hurdles mitochondria specific delivery of Qc nanocapsules were designed to efficiently counteract cerebral ischemia-reperfusion induced cell death and neurodegeneration in young and aged rats...
August 16, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28822840/role-of-adp-ribosylation-factor6-cytohesin1-phospholipased-signaling-axis-in-u46619-induced-activation-of-nadph-oxidase-in-pulmonary-artery-smooth-muscle-cell-membrane
#16
Sajal Chakraborti, Jaganmay Sarkar, Animesh Chowdhury, Tapati Chakraborti
Treatment of human pulmonary artery smooth muscle cells (HPASMCs) with the thromboxane A2 receptor antagonist, SQ29548 inhibited U46619 stimulation of phospholipase D (PLD) and NADPH oxidase activities in the cell membrane. Pretreatment with apocynin inhibited U46619 induced increase in NADPH oxidase activity. The cell membrane contains predominantly PLD2 along with PLD1 isoforms of PLD. Pretreatment with pharmacological and genetic inhibitors of PLD2, but not PLD1, attenuated U46619 stimulation of NADPH oxidase activity...
August 16, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28822807/spontaneous-activation-of-a-mavs-dependent-antiviral-signaling-pathway-determines-high-basal-interferon-%C3%AE-expression-in-cardiac-myocytes
#17
Efraín E Rivera-Serrano, Nicole DeAngelis, Barbara Sherry
Viral myocarditis is a leading cause of sudden death in young adults as the limited turnover of cardiac myocytes renders the heart particularly vulnerable to viral damage. Viruses induce an antiviral type I interferon (IFN-α/β) response in essentially all cell types, providing an immediate innate protection. Cardiac myocytes express high basal levels of IFN-β to help pre-arm them against viral infections, however the mechanism underlying this expression remains unclear. Using primary cultures of murine cardiac and skeletal muscle cells, we demonstrate here that the mitochondrial antiviral signaling (MAVS) pathway is spontaneously activated in unstimulated cardiac myocytes but not cardiac fibroblasts or skeletal muscle cells...
August 16, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/28822805/mg53-is-dispensable-for-t-tubule-maturation-but-critical-for-maintaining-t-tubule-integrity-following-cardiac-stress
#18
Caimei Zhang, Biyi Chen, Yihui Wang, Ang Guo, Yiqun Tang, Tahsin Khataei, Yun Shi, William J Kutschke, Kathy Zimmerman, Robert M Weiss, Jie Liu, Christopher J Benson, Jiang Hong, Jianjie Ma, Long-Sheng Song
The cardiac transverse (T)-tubule membrane system is the safeguard for cardiac function and undergoes dramatic remodeling in response to cardiac stress. However, the mechanism by which cardiomyocytes repair damaged T-tubule network remains unclear. In the present study, we tested the hypothesis that MG53, a muscle-specific membrane repair protein, antagonizes T-tubule damage to protect against maladaptive remodeling and thereby loss of excitation-contraction coupling and cardiac function. Using MG53-knockout (MG53-KO) mice, we first established that deficiency of MG53 had no impact on maturation of the T-tubule network in developing hearts...
August 16, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/28822766/pseudomonas-aeruginosa-increases-muc1-expression-in-macrophages-through-the-tlr4-p38-pathway
#19
Kosuke Kato, Alec D Hanss, Marina A Zemskova, Nicole E Morgan, Marianne Kim, Kenneth S Knox, Yong Lin, Erik P Lillehoj, Kwang Chul Kim
Alveolar macrophages (AMs) play a critical role in the clearance of Pseudomonas aeruginosa (Pa) from the airways. However, hyper-activation of macrophages can impair bacterial clearance and contribute to morbidity and mortality. MUC1 mucin is a membrane-tethered, high molecular mass glycoprotein expressed on the apical surface of mucosal epithelial cells and some hematopoietic cells, including macrophages, where it counter-regulates inflammation. We recently reported that Pa up-regulates the expression of MUC1 in primary human AMs and THP-1 macrophages, and that increased MUC1 expression in these cells prevents hyper-activation of macrophages that appears to be important for host defense against severe pathology of Pa lung infection...
August 16, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28822762/rab11a-is-required-for-porcine-reproductive-and-respiratory-syndrome-virus-induced-autophagy-to-promote-viral-replication
#20
Kai Wang, Shuaifeng Li, Tesfaye Worku, Xingjie Hao, Liaohan Yang, Shujun Zhang
Porcine reproductive and respiratory syndrome virus (PRRSV) is the leading virus known to cause massive economic loss in pig industry worldwide. In our previous study, transcriptional profiling of PRRSV-infected lung tissue of Tongcheng and landrane pigs, which have highly pathogenic PRRSV (HP-PRRSV) susceptibility differences, showed differential expression of Rab11a. The small GTPase Rab11a regulates intracellular membrane trafficking events involved in autophagy. However, the involvement of convergence of endosomal Rab11a and autophagy pathways during PRRSV infection is still unclear...
August 16, 2017: Biochemical and Biophysical Research Communications
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