keyword
https://read.qxmd.com/read/32813542/3-mst-h-2-s-protects-cerebral-endothelial-cells-against-ogd-r-induced-injury-via-mitoprotection-and-inhibition-of-the-rhoa-rock-pathway
#1
JOURNAL ARTICLE
Fang Zhang, Shuo Chen, Ji-Yue Wen, Zhi-Wu Chen
3-mercaptopyruvate sulfurtransferase (3-MST) is the major source of hydrogen sulfide (H2 S) production in the brain and participates in many physiological and pathological processes. The present study was designed to investigate the role of 3-MST-derived H2 S (3-MST/H2 S) on oxygen-glucose deprivation/reoxygenation (OGD/R) injury in cerebrovascular endothelial cells (ECs). Using cerebrovascular specimens from patients with acute massive cerebral infarction (MCI), we found abnormal morphology of the endothelium and mitochondria, as well as decreases in H2 S and 3-MST levels...
August 19, 2020: American Journal of Physiology. Cell Physiology
https://read.qxmd.com/read/31728622/mntnbuoe-2-pyp-treatment-protects-from-radioactive-iodine-i-131-treatment-related-side-effects-in-thyroid-cancer
#2
JOURNAL ARTICLE
Anery Patel, Elizabeth A Kosmacek, Kurt W Fisher, Whitney Goldner, Rebecca E Oberley-Deegan
Treatment of differentiated thyroid cancer often involves administration of radioactive iodine (I-131) for remnant ablation or adjuvant therapy. However, there is morbidity associated with I-131 therapy, which can result in both acute and chronic complications. Currently, there are no approved radioprotectors that can be used in conjunction with I-131 to reduce complications in thyroid cancer therapy. It is well known that the damaging effects of ionizing radiation are mediated, in part, by the formation of reactive oxygen species (ROS)...
November 14, 2019: Radiation and Environmental Biophysics
https://read.qxmd.com/read/30172779/acute-oxygen-sensing-role-of-metabolic-specifications-in-peripheral-chemoreceptor-cells
#3
REVIEW
Lin Gao, Patricia Ortega-Sáenz, José López-Barneo
Acute oxygen sensing is essential for humans under hypoxic environments or pathologic conditions. This is achieved by the carotid body (CB), the key arterial chemoreceptor, along with other peripheral chemoreceptor organs, such as the adrenal medulla (AM). Although it is widely accepted that inhibition of K+ channels in the plasma membrane of CB cells during acute hypoxia results in the activation of cardiorespiratory reflexes, the molecular mechanisms by which the hypoxic signal is detected to modulate ion channel activity are not fully understood...
August 30, 2018: Respiratory Physiology & Neurobiology
https://read.qxmd.com/read/17115906/alkoxyl-radical-scavenging-activity-of-edaravone-in-patients-with-traumatic-brain-injury
#4
JOURNAL ARTICLE
Kenji Dohi, Kazue Satoh, Yuko Mihara, Shunsuke Nakamura, Yasuhumi Miyake, Hirokazu Ohtaki, Tomoya Nakamachi, Toshikazu Yoshikawa, Seiji Shioda, Tohru Aruga
Lipid peroxidation is caused by reactive oxygen species (ROS) and is involved in traumatic brain injury (TBI). Consequently, a therapeutic strategy for TBI may be to control lipid peroxidation. The only drug approved to date for blocking lipid peroxidation is edaravone (MCI-186), a novel free-radical scavenger shown to exert neuroprotective effects in acute ischemic stroke. Although edaravone scavenges hydroxyl and nitric oxide radicals, its effect on alkoxyl radicals (OR-), which also contribute to lipid peroxidation, is unknown...
November 2006: Journal of Neurotrauma
https://read.qxmd.com/read/16880614/mci-186-3-methyl-1-phenyl-2-pyrazolin-5-one-attenuated-simulated-ischemia-reperfusion-injury-in-cultured-rat-hippocampal-cells
#5
JOURNAL ARTICLE
Ting Wu, Xin-Sheng Ding, Wei Wang, Jin Wu
The reactive oxygen species and Ca2+ overload play a critical role in ischemia/reperfusion (I/R) injury. MCI-186 has potent effects in the brain as a free radical scavenger in ischemia-reperfusion. Acute glucose-oxygen deprivation and subsequent reoxygenation were used to model ischemia/reperfusion injury in cultured hippocampal cells. MCI-186 reduced malondialdehyde level and raised the SOD activity when applied upon reoxygenation in a dose-dependent manner compared with the untreated group. The peak neuroprotective effects occurred at 100 and 300 microM...
August 2006: Biological & Pharmaceutical Bulletin
https://read.qxmd.com/read/15466246/a-newly-synthesized-poly-adp-ribose-polymerase-inhibitor-dr2313-2-methyl-3-5-7-8-tetrahydrothiopyrano-4-3-d-pyrimidine-4-one-pharmacological-profiles-neuroprotective-effects-and-therapeutic-time-window-in-cerebral-ischemia-in-rats
#6
COMPARATIVE STUDY
Hidemitsu Nakajima, Nobukazu Kakui, Kunihiro Ohkuma, Midori Ishikawa, Toshifumi Hasegawa
We investigated the pharmacological profiles of DR2313 [2-methyl-3,5,7,8-tetrahydrothiopyrano[4,3-d]pyrimidine-4-one], a newly synthesized poly(ADP-ribose) polymerase (PARP) inhibitor, and its neuroprotective effects on ischemic injuries in vitro and in vivo. DR2313 competitively inhibited poly(ADP-ribosyl)ation in nuclear extracts of rat brain in vitro (K(i) = 0.23 microM). Among several NAD(+)-utilizing enzymes, DR2313 was specific for PARP but not selective between PARP-1 and PARP-2. DR2313 also showed excellent profiles in water solubility and rat brain penetrability...
February 2005: Journal of Pharmacology and Experimental Therapeutics
https://read.qxmd.com/read/12649298/a-novel-free-radical-scavenger-edarabone-protects-against-cisplatin-induced-acute-renal-damage-in-vitro-and-in-vivo
#7
JOURNAL ARTICLE
Minoru Satoh, Naoki Kashihara, Sohachi Fujimoto, Hideyuki Horike, Takehiko Tokura, Tamehachi Namikoshi, Tamaki Sasaki, Hirofumi Makino
Accumulating evidence suggests that enhanced peroxidative damage caused by reactive oxygen species (ROS) may contribute to the pathogenesis of cisplatin-induced acute renal failure. Nevertheless, little is known about the involvement of oxygen radicals in cisplatin nephropathy. In this study, we investigated the effects of a novel free radical scavenger, 3-methyl-1-phenyl-pyrazolin-5-one (MCI-186; edarabone), on murine proximal tubular cell (PTC) damage induced by exposure to cisplatin in vitro and on renal function in an in vivo model of cisplatin-induced acute renal failure...
June 2003: Journal of Pharmacology and Experimental Therapeutics
https://read.qxmd.com/read/7648672/myocardial-kinetics-of-a-putative-hypoxic-tissue-marker-99mtc-labeled-nitroimidazole-bms-181321-after-regional-ischemia-and-reperfusion
#8
JOURNAL ARTICLE
C K Stone, T Mulnix, R J Nickles, B Renstrom, S H Nellis, A J Liedtke, A D Nunn, B L Kuczynski, W L Rumsey
BACKGROUND: A new nitroimidazole complex, 99mTc-propylene amine oxime-1,2-nitroimidazole (BMS-181321), has been developed to allow the positive imaging of hypoxic myocardium by standard gamma camera techniques. METHODS AND RESULTS: To determine the myocardial kinetics of BMS-181321 during myocardial ischemia and reperfusion, seven open-chest swine were prepared according to a model of extracorporeal coronary perfusion in which left ventricular wall thickening (percent end-diastolic thickness) and substrate use in the left anterior descending (LAD) region ([14C]palmitate and [3H]glucose infusions) were determined...
September 1, 1995: Circulation
https://read.qxmd.com/read/3872130/-cerebral-blood-flow-cerebral-oxygen-metabolism-cerebral-glucose-metabolism-and-tissue-ph-in-human-acute-cerebral-infarction-using-positron-emission-tomography
#9
JOURNAL ARTICLE
S Kitamura, A Kato, Y L Yamamoto, A M Hakim, M Diksic, E Meyer, J Tyler, C Thompson, R Pokrupa
It is necessary for treatment and deciding prognosis to make clear about changes of cerebral blood flow and metabolism in acute cerebral infarction. This preliminary PET study was designed to investigate physiological and biochemical changes in acute cerebral infarction by positron emission tomography (PET). PET studies were performed in six patients with acute cerebral infarction within 48 hours after onset of stroke using continuous inhalation of C15O2 for cerebral blood flow (CBF), 15O2 for cerebral metabolic rate for oxygen (CMRO2), 11CO for cerebral blood volume, the intravenous injection of 11C-dimethyloxazolidinedione for tissue pH and the intravenous injection of 18F-fluorodeoxyglucose for cerebral metabolic rate for glucose (CMRGlu)...
January 1985: Nō to Shinkei, Brain and Nerve
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