Kenji Dohi, Kazue Satoh, Yuko Mihara, Shunsuke Nakamura, Yasuhumi Miyake, Hirokazu Ohtaki, Tomoya Nakamachi, Toshikazu Yoshikawa, Seiji Shioda, Tohru Aruga
Lipid peroxidation is caused by reactive oxygen species (ROS) and is involved in traumatic brain injury (TBI). Consequently, a therapeutic strategy for TBI may be to control lipid peroxidation. The only drug approved to date for blocking lipid peroxidation is edaravone (MCI-186), a novel free-radical scavenger shown to exert neuroprotective effects in acute ischemic stroke. Although edaravone scavenges hydroxyl and nitric oxide radicals, its effect on alkoxyl radicals (OR-), which also contribute to lipid peroxidation, is unknown...
November 2006: Journal of Neurotrauma