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https://www.readbyqxmd.com/read/27916508/development-of-gestation-specific-reference-intervals-for-thyroid-hormones-in-normal-pregnant-northeast-chinese-women-what-is-the-rational-division-of-gestation-stages-for-establishing-reference-intervals-for-pregnancy-women
#1
Jianhua Liu, Xiaojun Yu, Meng Xia, Hong Cai, Guixue Cheng, Lina Wu, Qiang Li, Ying Zhang, Mengyuan Sheng, Yong Liu, Xiaosong Qin
BACKGROUND: A laboratory- and region-specific trimester-related reference interval for thyroid hormone assessment of pregnant women were recommended. Whether the division by trimester is suitable requires verification. Here, we tried to establish appropriate reference intervals of thyroid-related hormones and antibodies for normal pregnant women in Northeast China. METHODS: A total of 947 pregnant women who underwent routine prenatal care were grouped via two methods...
December 1, 2016: Clinical Biochemistry
https://www.readbyqxmd.com/read/27914474/thyroid-hormones-associate-with-risk-of-incident-chronic-kidney-disease-and-rapid-decline-in-renal-function-a-prospective-investigation
#2
Xiaolin Huang, Lin Ding, Kui Peng, Lin Lin, Tiange Wang, Zhiyun Zhao, Yu Xu, Jieli Lu, Yuhong Chen, Weiqing Wang, Yufang Bi, Guang Ning, Min Xu
BACKGROUND: Thyroid hormones have been associated with renal dysfunction in cross-sectional studies. However, prospective studies exploring the effect of thyroid hormones on renal function decline were sparse and got contradictive results. We aimed to prospectively explore the associations of thyroid hormones with incident chronic kidney disease (CKD) and rapid decline in estimated glomerular filtration rate (eGFR) in Chinese adults. METHODS: The participants were from a community-based cohort including 2103 individuals aged 40 years or above without CKD at baseline...
December 3, 2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27910708/myo-inositol-and-melatonin-in-the-menopausal-transition
#3
Rosario D'Anna, Angelo Santamaria, Grazia Giorgianni, Alberto Vaiarelli, Giuseppe Gullo, Flavia Di Bari, Salvatore Benvenga
INTRODUCTION: The aim of the study was to evaluate the effects on serum insulin and serum thyroid profile of a dietary supplement, myo-inositol, given alone or in combination with melatonin to women during menopausal transition. METHODS: Forty women aged 45-55 years and at least 6 months of amenorrhea were enrolled in this study. They were randomly assigned to two groups of 20 each. One group took myo-inositol (myo-Ins) (2 g twice a day) and the other group took 2 g/d myo-Ins plus 3 g/d melatonin before sleeping...
December 2, 2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/27906594/the-relationship-between-thyroid-function-and-the-prevalence-of-type-2-diabetes-mellitus-in-euthyroid-subjects
#4
Yeqing Gu, Huihui Li, Xue Bao, Qing Zhang, Li Liu, Ge Meng, Hongmei Wu, Huanmin Du, Hongbin Shi, Yang Xia, Qian Su, Liyun Fang, Fei Yu, Huijun Yang, Bin Yu, Shaomei Sun, Xing Wang, Ming Zhou, Qiyu Jia, Qi Guo, Hong Chang, Guolin Wang, Guowei Huang, Kun Song, Kaijun Niu
PURPOSE: The thyroid hormones (TH) are primarily responsible for the regulation of energy balance and metabolism, suggesting that TH levels may contribute to the development of type 2 diabetes mellitus (T2DM). However, few studies have investigated the relationship between TH and T2DM in a general population. The aim of this study is to evaluate whether serum TH levels within the reference range are related to T2DM. METHODS: A cross-sectional study (n=15,296) was performed in Tianjin, China...
December 1, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27904425/association-of-thyroid-profile-and-prolactin-level-in-patient-with-secondary-amenorrhea
#5
Sujata Shrestha, Sunita Neupane, Narayan Gautam, Raju Kumar Dubey, Amit Chandra Jha, Nilesh Raj Doshi, Archana Jayan
BACKGROUND: Amenorrhea is the absence of menstrual periods. It has multiple social consequences as it may leads to infertility. This case control study was conducted for determining the association of thyroid hormones with hyperprolactinemia in patient with amenorrhea. METHODS: We investigated 50 women with diagnosed cases of secondary amenorrhoea, who attended UCMS hospital, for hormonal evaluations. Fifty two healthy women were taken as the controls. The thyroid dysfunction and serum prolactin level were reviewed in cases and in the controls...
September 2016: Malaysian Journal of Medical Sciences: MJMS
https://www.readbyqxmd.com/read/27904073/a-case-of-familial-dysalbuminemic-hyperthyroxinemia-fdh-in-japan-fdh-as-a-possible-differential-diagnosis-of-syndrome-of-inappropriate-secretion-of-thyroid-stimulating-hormone-sitsh
#6
Sakiko Kobayashi, Jaeduk Yoshimura Noh, Taeko Shimizu, Tomoaki Sato, Isao Kurihara, Kiminori Sugino, Hiroshi Itoh, Koichi Ito
Familial dysalbuminemic hyperthyroxinemia (FDH) is an autosomal dominant condition and is the most commonly inherited euthyroid hyperthyroxinemia in Caucasians. However, it is extremely rare in Asian populations. A 30-year-old Japanese woman, who was incidentally found to have apparent thyroid dysfunction, was admitted to our hospital in 2004. She had extremely elevated serum free thyroxine (FT4), moderately elevated free triiodothyronine (FT3), and normal thyroid-stimulating hormone (TSH). Clinical thyroid examination revealed no abnormalities other than small goiter...
November 30, 2016: Endocrine Journal
https://www.readbyqxmd.com/read/27892665/thyroid-function-after-postoperative-radiation-therapy-in-patients-with-breast-cancer
#7
Edyta Wolny-Rokicka, Andrzej Tukiendorf, Jerzy Wydmański, Danuta Roszkowska, Bogusław Staniul, Agnieszka Zembroń-Łacny
Objective: The aim of this study was to assess thyroid function in breast cancer patients exposed to therapeutic external beam radiation. The focus was on possible progressive changes and any relationships between the incidence of primary hypothyroidism, the time required to become hypothyroid, and factors such as chemotherapy, hormonotherapy and immunotherapy. Materials and Methods: Seventy females undergoing 3D conformal and IMRT radiation therapy for breast cancers were enrolled in a non-randomized prospective study...
January 10, 2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27890823/assessment-of-thyroid-function-in-intensive-care-unit-patients-by-liquid-chromatography-tandem-mass-spectrometry-methods
#8
Kerry J Welsh, Brian R Stolze, Xiaolin Yu, Trisha R Podsiadlo, Lisa S Kim, Steven J Soldin
OBJECTIVES: Patients with non-thyroidal illness syndrome have many abnormalities in thyroid hormone tests. Such patients have medical comorbidities associated with low serum proteins and are on multiple medications that interfere with thyroid hormone measurement by immunoassay platforms. It is unknown if these thyroid hormone measurements reflect physiologic conditions or if they are artifacts of testing methodology. METHODS: Fifty patients were selected from the intensive care unit (ICU) from our institution...
November 25, 2016: Clinical Biochemistry
https://www.readbyqxmd.com/read/27872610/relational-stability-in-the-expression-of-normality-variation-and-control-of-thyroid-function
#9
REVIEW
Rudolf Hoermann, John E M Midgley, Rolf Larisch, Johannes W Dietrich
Thyroid hormone concentrations only become sufficient to maintain a euthyroid state through appropriate stimulation by pituitary thyroid-stimulating hormone (TSH). In such a dynamic system under constant high pressure, guarding against overstimulation becomes vital. Therefore, several defensive mechanisms protect against accidental overstimulation, such as plasma protein binding, conversion of T4 into the more active T3, active transmembrane transport, counter-regulatory activities of reverse T3 and thyronamines, and negative hypothalamic-pituitary-thyroid feedback control of TSH...
2016: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/27867885/trimester-specific-reference-interval-for-thyroid-hormones-during-pregnancy-at-a-tertiary-care-hospital-in-haryana-india
#10
Rajesh Rajput, Bhagat Singh, Vasudha Goel, Amit Verma, Shashi Seth, Smiti Nanda
BACKGROUND: Reference intervals for thyroid hormone during pregnancy need to be gestational age, method, and population specific and there is need to establish trimester-specific thyroid levels for the different population across the world. The aim of this study was to establish trimester-specific reference range for thyroid hormone during pregnancy in a tertiary care center in Haryana. MATERIALS AND METHODS: A total of 1430 pregnant women were recruited for the study...
November 2016: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27849383/free-thyroid-hormones-and-mortality-in-caucasians-undergoing-angiography-the-ludwigshafen-risk-and-cardiovascular-health-luric-study
#11
Anette Merke, Jürgen Merke, Guenther Silbernagel, Winfried März
TITLE: Free Thyroid Hormones and Mortality in Caucasians undergoing Angiography: The LUdwigshafen RIsk and Cardiovascular Health Study (LURIC) Objective: Alterations in thyroid hormone functions are associated with mortality and morbidity. Data on euthyroid individuals are very limited and controversial. We therefore investigated the relationship between circulating thyroid hormones and all-cause and cardiovascular (CV) mortality in participants of the LURIC study and their association with morbidity...
November 16, 2016: Endocrine Practice
https://www.readbyqxmd.com/read/27849377/in-patients-with-subclinical-hypothyroidism-while-in-therapy-with-tablet-l-t4-the-liquid-l-t4-formulation-is-more-effective-in-restoring-euthyroidism
#12
Poupak Fallahi, Silvia Martina Ferrari, Alessandro Antonelli
OBJECTIVE: Levothyroxine (L-T4) is the standard therapy of hypothyroidism. Our purpose is to compare the effectiveness of L-T4 liquid formulation, with respect to L-T4 tablet, in hypothyroid patients without malabsorption or drug interference. METHODS: Twentyone subjects with high thyroid-stimulating hormone (TSH) values under therapy with L-T4 tablets were switched to liquid L-T4 at the same dosage, 30 minutes before breakfast. RESULTS: TSH values significantly declined after 2 months from the switch to liquid L-T4, reaching in most cases the normal range...
November 16, 2016: Endocrine Practice
https://www.readbyqxmd.com/read/27843807/relational-stability-of-thyroid-hormones-in-euthyroid-subjects-and-patients-with-autoimmune-thyroid-disease
#13
Rudolf Hoermann, John E M Midgley, Rolf Larisch, Johannes W Dietrich
BACKGROUND/AIM: Operating far from its equilibrium resting point, the thyroid gland requires stimulation via feedback-controlled pituitary thyrotropin (TSH) secretion to maintain adequate hormone supply. We explored and defined variations in the expression of control mechanisms and physiological responses across the euthyroid reference range. METHODS: We analyzed the relational equilibria between thyroid parameters defining thyroid production and thyroid conversion in a group of 271 thyroid-healthy subjects and 86 untreated patients with thyroid autoimmune disease...
September 2016: European Thyroid Journal
https://www.readbyqxmd.com/read/27835928/population-based-national-prevalence-of-thyroid-dysfunction-in-spain-and-associated-factors-di-bet-es-study
#14
Sergio Valdes, Cristina Maldonado-Araque, Ana Lago-Sampedro, J Antonio Lillo, Eduardo Garcia-Fuentes, Vidal Perez, Carolina Gutierrez-Repiso, Pilar Ocon-Sanchez, Albert Goday-Arno, Ines Urrutia, Laura Pelaez, Alfonso Calle-Pascual, Elena Bordiú, Luis Castaño, Conxa Castell, Elias Delgado Álvarez, Edelmiro Menendez, Josep Franch, Sonia Gaztambide, Joan Girbés, Emilio Ortega, Alfonso Lopez-Alba, Felipe J Chaves, Joan Vendrell, Matilde Rodriguez Chacon, Federico Soriguer, Gemma Rojo-Martinez
BACKGROUND: The aim of this study was to investigate the national prevalence of thyroid dysfunction in Spain, and its association with various clinical, environmental and demographic variables. METHODS: The present report includes 4554 people (42.4% men) with a mean age of 50 years (range 18-93 years) participants in a national, cross-sectional, population-based survey conducted in 2009-10. Data gathered included clinical and demographic characteristics, physical examination and blood sampling...
November 11, 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27835810/gallic-acid-attenuates-chromium-induced-thyroid-dysfunction-by-modulating-antioxidant-status-and-inflammatory-cytokines
#15
Hanaa M Mohamed, Sanaa M Abd El-Twab
Hexavalent chromium-mediated oxidative stress causes severe organ damage. The present study was designed to investigate the possible thyroprotective effect and underlying mechanisms of gallic acid using rat model of potassium dichromate-induced thyroid dysfunction. Forty adult male albino rats were divided into 4 groups: control, gallic acid (20mg GA/kg b. wt), potassium dichromate (2mg PD/kg b. wt) and the fourth group was co-treated with PD and GA. PD-injection resulted in decreased serum free triiodothyonine (FT3), free thyroxine (FT4) with concomitant significant increase in thyroid stimulating hormone (TSH) levels...
December 2016: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/27816062/using-hashimoto-thyroiditis-as-gold-standard-to-determine-the-upper-limit-value-of-thyroid-stimulating-hormone-in-a-chinese-cohort
#16
Yu Li, Dong-Ning Chen, Jing Cui, Zhong Xin, Guang-Ran Yang, Ming-Jia Niu, Jin-Kui Yang
BACKGROUND: Subclinical hypothyroidism, commonly caused by Hashimoto thyroiditis (HT), is a risk factor for cardiovascular diseases. This disorder is defined as merely having elevated serum thyroid stimulating hormone (TSH) levels. However, the upper limit of reference range for TSH is debated recently. This study was to determine the cutoff value for the upper normal limit of TSH in a cohort using the prevalence of Hashimoto thyroiditis as "gold" calibration standard. METHODS: The research population was medical staff of 2856 individuals who took part in health examination annually...
November 6, 2016: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/27809617/d2-thr92ala-thyroid-hormone-levels-and-biochemical-hypothyroidism-in-preeclampsia
#17
Lucia Maria Procopciuc, Gabriela Caracostea, Georgeta Hazi, Georgiana Nemeti, Florin Stamatian
AIM: To identify if there is a relationship between the deiodinase D2-Thr92Ala genetic variant, thyroid hormone levels and biochemical hypothyroidism in preeclampsia. MATERIALS AND METHODS: We genotyped 125 women with preeclampsia and 131 normal pregnant women using PCR-RFLP. Serum thyroid hormone levels were determined using ELISA. RESULTS: Our study showed higher TSH and FT4 levels and lower FT3 levels in women with preeclampsia compared to normal pregnant women, with statistical significance for women with mild and severe preeclampsia...
November 4, 2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/27795209/trimester-specific-thyroid-hormone-reference-ranges-in-sudanese-women
#18
Enaam T Elhaj, Ishag Adam, Mohamed A Ahmed, Mohamed F Lutfi
BACKGROUND: Trimester-specific reference ranges for T3, T4, and TSH need to be established in different communities. Neither Sudan nor other African countries have established trimester-specific reference ranges for TSH, free T3 (FT3), and free T4 (FT4) in healthy pregnant women. This study aimed to establish trimester-specific reference ranges for TSH, FT3, and FT4 in healthy pregnant Sudanese women. RESULTS: We performed a longitudinal study, which included 63 women with singleton pregnancies who were followed since early pregnancy until the third trimester...
October 31, 2016: BMC Physiology
https://www.readbyqxmd.com/read/27792263/the-prevalence-of-impaired-glucose-regulation-in-anxiety-disorder-patients-and-the-relationship-with-hypothalamic-pituitary-adrenal-axis-and-hypothalamic-pituitary-thyroid-axis-activity
#19
Yaling Zhou, Zaiquan Dong, Ruhan A, Zongbing Liao, Jing Guo, Cancan Liu, Xueli Sun
OBJECTIVE: To investigate the prevalence of impaired glucose regulation (IGR) in patients with anxiety disorders and the relationship with hypothalamic-pituitary-adrenal (HPA) and hypothalamic-pituitary-thyroid (HPT) axes function. METHODS: From September 2013 to May 2015, a total of 646 patients with anxiety disorders who matched the criteria of the 10(th) revision of the International Statistical Classification of Diseases and Related Health Problems participated in our study, which was conducted in the Psychiatric Inpatient Department of the West China Hospital of Sichuan University...
August 29, 2016: Journal of Evidence-based Medicine
https://www.readbyqxmd.com/read/27790421/a-study-to-assess-the-validity-of-estimation-of-serum-ostase-level-in-hyperthyroid-and-hypothyroid-cases
#20
Polina Boruah, Arup Jyoti Baruah, Ranendra Hajong, Chandan Kumar Nath, Bhupen Barman, Happy Chutia, Kalyan Sarma
INTRODUCTION: One of the more specific assessments of the metabolic status of bone in normal and in disease conditions is the measurement of bone specific alkaline phosphatase or ostase. The measurement of serum ostase has several advantages over the measurements of other bone parameter. Because of its relatively long half-life, in-vivo (1 to 3days), it is relatively unaffected by diurnal variation. AIM: To find the correlation of serum ostase level in hyper and hypothyroid cases and also to study the validity of routine estimation of serum ostase in hyper and hypothyroid cases so as to monitor the base level bone health on presentation...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
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