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https://www.readbyqxmd.com/read/29666563/do-tsh-ft3-and-ft4-impact-bat-visualization-of-clinical-fdg-pet-ct-images
#1
Ryuichi Nishii, Shigeki Nagamachi, Youichi Mizutani, Tamasa Terada, Syogo Kiyohara, Hideyuki Wakamatsu, Seigo Fujita, Tatsuya Higashi, Keiichiro Yoshinaga, Tsuneo Saga, Toshinori Hirai
Objective: We retrospectively analyzed activated BAT visualization on FDG-PET/CT in patients with various conditions and TH levels to clarify the relationships between visualization of BAT on FDG-PET/CT and the effect of TH. Methods: Patients who underwent clinical FDG-PET/CT were reviewed and we categorized patients into 5 groups: (i) thyroid hormone withdrawal (THW) group; (ii) recombinant human thyrotropin (rhTSH) group; (iii) hypothyroidism group; (iv) hyperthyroidism group; and (v) BAT group...
2018: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29665650/selenium-nanoparticles-prevents-lead-acetate-induced-hypothyroidism-and-oxidative-damage-of-thyroid-tissues-in-male-rats-through-modulation-of-selenoenzymes-and-suppression-of-mir-224
#2
Hebatallah Husseini Atteia, Manar Hamed Arafa, Kousalya Prabahar
Selenium nanoparticles (Se-NPs) are customizable drug delivery vehicles that show good bioavailability, higher efficacy and lower toxicity than ordinary Se. Pre-treatment of male rats with these NPs has been recently shown to exert a protective effect against chromium-induced thyroid dysfunction. This study, therefore, aimed to investigate and characterize the potential protective mechanism of Se-NPs against lead (Pb) acetate-induced thyrotoxicity. We found that prophylactic and concurrent treatment of Pb acetate-exposed rats with Nano-Se (0...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29660579/the-effect-of-dermal-benzophenone-2-administration-on-immune-system-activity-hypothalamic-pituitary-thyroid-axis-activity-and-hematological-parameters-in-male-wistar-rats
#3
Żaneta Broniowska, Joanna Ślusarczyk, Beata Starek-Świechowicz, Ewa Trojan, Bartosz Pomierny, Weronika Krzyżanowska, Agnieszka Basta-Kaim, Bogusława Budziszewska
Benzophenones used as UV filters, in addition to the effects on the skin, can be absorbed into the blood and affect the function of certain organs. So far, their effects on the sex hormone receptors and gonadal function have been studied, but not much is known about their potential action on other systems. The aim of the present study was to determine the effect of benzophenone-2 (BP-2) on immune system activity, hypothalamic-pituitary-thyroid (HPT) axis activity and hematological parameters. BP-2 was administered dermally, twice daily at a dose of 100 mg/kg for 4-weeks to male Wistar rats...
April 13, 2018: Toxicology
https://www.readbyqxmd.com/read/29660205/thyroid-hormones-and-diabetic-nephropathy-an-essential-relationship-to-recognize
#4
Qianqian Han, Junlin Zhang, Yiting Wang, Hanyu Li, Rui Zhang, Ruikun Guo, Li Li, Geer Teng, Jiali Wang, Tingli Wang, Fang Liu
AIMS: Although abnormal thyroid hormone metabolism is common in patients with 2 diabetes mellitus (T2DM) and diabetic nephropathy (DN), the relationship between thyroid hormones and DN is unclear and being ignored during the clinical practice. This study was aimed to investigate the relationship between thyroid hormones and clinicopathologic changes in biopsy-proven DN patients. METHODS: We collected clinical and pathological data for 146 biopsy-proven DN patients...
April 16, 2018: Nephrology
https://www.readbyqxmd.com/read/29658834/alterations-in-thyroid-hormone-levels-following-growth-hormone-replacement-exert-complex-biological-effects
#5
Nigel Glynn, Helena Kenny, Tarik Salim, David J Halsall, Diarmuid Smith, Tommy Kyaw Tun, John H McDermott, William Tormey, Christopher J Thompson, Brendan McAdam, Donal O' Gorman, Amar Agha
OBJECTIVE: Alterations in the thyroid axis are frequently observed following growth hormone (GH) replacement, but uncertainty exists regarding their clinical significance. We aimed to compare fluctuations in circulating thyroid hormone levels, induced by GH, to changes in sensitive biological markers of thyroid hormone action. METHODS: This was a prospective observational clinical study. Twenty hypopituitary men were studied before and after GH replacement. Serum thyroid-stimulating hormone (TSH), thyroid hormones, and insulin-like growth factor 1 were measured...
April 2018: Endocrine Practice
https://www.readbyqxmd.com/read/29628400/-prevalence-and-prognostic-value-of-non-thyroidal-illness-syndrome-among-critically-ill-children
#6
Sohair Sayed Abu El-Ella, Muhammad Said El-Mekkawy, Mohamed Abdelrahman El-Dihemey
INTRODUCTION: Alterations in thyroid hormones during critical illness, known as non-thyroidal illness syndrome (NTIS), were suggested to have a prognostic value. However, pediatric data is limited. The aim of this study was to assess prevalence and prognostic value of NTIS among critically ill children. MATERIALS AND METHODS: A prospective observational study conducted on 70 critically ill children admitted into pediatric intensive care unit (PICU). Free triiodothyronine (FT3), free thyroxine (FT4), and thyroid stimulating hormone (TSH) were measured within 24hours of PICU admission...
April 5, 2018: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/29627743/the-value-of-shear-wave-elastography-in-diffuse-thyroid-disease
#7
Jianxue Liu, Yaoren Zhang, Yonghao Ji, Qinyun Wan, Guoliang Dun
PURPOSE: The aim of this study is to discuss the value of ultrasound-based shear wave™ elastography (SWE) in diffuse thyroid disease (DTD). METHOD: Thyroid stiffness in 154 patients with DTD and 30 normal subjects was measured by SWE. The serum indicators of all subjects were detected. RESULTS: The area under the receiver operating characteristic (AUROC) curve for DTD by SWE was 0.852. The AUROCs of SWE for differentiating chronic autoimmune thyroiditis (CAT) from Graves' disease (GD) and subacute thyroiditis (SAT) were 0...
March 29, 2018: Clinical Imaging
https://www.readbyqxmd.com/read/29624094/percutaneous-ethanol-injection-for-benign-cystic-and-mixed-thyroid-nodules
#8
A Ozderya, K Aydin, N Gokkaya, S Temizkan
BACKGROUND/AIM: We aimed to determine the effect of percutaneous ethanol injection (PEI) on volume of cystic and mixed thyroid nodules, thyroid function tests (TFTs), antibody titers and cytological changes for 1 year. METHODS: Fifty-five nodules of 53 patients with cystic and mixed properties treated with PEI were included. Nodule volumes, TFTs, thyroid autoantibodies were analyzed at baseline, 6th and 12th months. Fine needle aspiration biopsy (FNAB) was performed to PEI applied nodules in the 12th month...
April 6, 2018: Endocrine Practice
https://www.readbyqxmd.com/read/29623823/low-25-hydroxyvitamin-d-levels-are-independently-associated-with-autoimmune-thyroiditis-in-a-cohort-of-apparently-healthy-overweight-and-obese-subjects
#9
Giovanni De Pergola, Vincenzo Triggiani, Nicola Bartolomeo, Vito Angelo Giagulli, Michele Anelli, Michele Masiello, Vittoria Candita, Dario De Bellis, Franco Silvestris
BACKGROUND: Low vitamin D levels have been associated with autoimmune disorders and, then, with the Hashimoto's autoimmune thyroiditis (AT), the most common autoimmune disease. Obesity is characterized by lower vitamin D levels and higher risk to develop autoimmune diseases. The aim of the study was to examine the possibility of an association between AT and decreased 25(OH) vitamin D (25(OH)D) levels in a cohort of otherwise healthy overweight and obese subjects. MATERIALS AND METHODS: Two hundred sixty one overweight subjects (mean age: 40...
April 6, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29623516/sensitivity-of-supplementation-of-thyroid-hormone-on-treatment-of-idiopathic-short-stature-children-during-therapy-with-recombinant-human-growth-hormone
#10
Wei Wang, Shuqin Jiang, Zhirui Cui, Xiangyang Luo, Lingli Shi, Heli Zheng
This study aimed to evaluate the effects of thyroid hormone supplementation on growth rate of children with idiopathic short stature (ISS) and low-normal serum free thyroxine FT4 who were receiving growth hormone therapy. We selected 64 prepubertal children with FT4 levels in the lowest third of the normal range as the lower FT4 group, and these children were divided randomly into two subgroups: L-thyroxine (L-T4)-treated subgroup was treated with L-T4 (0.5-3.0 g/(kg·d)) from the beginning of the study, and the non-L-T4-treated subgroup received placebo...
April 6, 2018: Frontiers of Medicine
https://www.readbyqxmd.com/read/29615976/higher-prevalence-of-low-t3-syndrome-in-patients-with-chronic-fatigue-syndrome-a-case-control-study
#11
Begoña Ruiz-Núñez, Rabab Tarasse, Emar F Vogelaar, D A Janneke Dijck-Brouwer, Frits A J Muskiet
Chronic fatigue syndrome (CFS) is a heterogeneous disease with unknown cause(s). CFS symptoms resemble a hypothyroid state, possibly secondary to chronic (low-grade) (metabolic) inflammation. We studied 98 CFS patients (21-69 years, 21 males) and 99 age- and sex-matched controls (19-65 years, 23 males). We measured parameters of thyroid function, (metabolic) inflammation, gut wall integrity and nutrients influencing thyroid function and/or inflammation. Most remarkably, CFS patients exhibited similar thyrotropin, but lower free triiodothyronine (FT3) (difference of medians 0...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29614583/-long-term-prognostic-value-of-lowering-in-free-triiodothyronine-in-patients-with-hypertrophic-cardiomyopathy
#12
X B Meng, W Y Wang, K Zhang, Y Qi, S M An, S Y Wang, J L Zheng, Q J Yu, B Tang, R Wu, C Y Gao, S Y Wang, Y D Tang
Objective: To determine whether thyroid hormone (TH) level could also be an independent and incremental predictor of adverse events in patients with hypertrophic cardiomyopathy (HCM). Methods: A total of 982 consecutive patients with HCM at the National Center for Cardiovascular Diseases (China) from October 2009 to December 2013 were included in the present study, and followed up till the end of December 2016. The patients were divided into three groups according to the levels of free triiodothyronine (FT3 ): the group 1 (FT3 ≤4...
April 1, 2018: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/29610606/thyroid-function-and-25-oh-vitamin-d-level-among-sudanese-women-in-early-pregnancy
#13
Imad R Musa, Duria A Rayis, Mohmamed A Ahmed, Ammar H Khamis, Abubakr M Nasr, Ishag Adam
AIM: A cross-sectional study was conducted at Saad Abualila Hospital (Khartoum, Sudan) to evaluate the vitamin D levels and thyroid function among pregnant Sudanese women (132) in early pregnancy. METHODS: A cross-sectional study was conducted at Saad Abualila hospital (Khartoum, Sudan) during the period from March to July 2015. Women who were in early pregnancy with a singleton pregnancy were approached to participate in the study after signing informed consent...
March 15, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29610063/association-between-free-thyroid-hormones-values-and-the-lipid-profile-in-middle-aged-women-with-chronic-symptoms
#14
Mirella Guarnizo-Poma, Socorro Paico-Palacios, Betzi Pantoja-Torres, Herbert Lazaro-Alcantara, Diego Urrunaga-Pastor, Vicente A Benites-Zapata
AIMS: To determine the association between the thyroid hormones(FT3, FT4 and TSH) and the lipid profile markers(HDL-c, LDL-c and triglycerides) values in middle-aged women with no metabolic disorders and recurrent chronic symptomatology. MATERIALS AND METHODS: We carried out an analytical cross-sectional study in euthyroid women with recurrent chronic symptoms of at least six months with no apparent diagnosis who attended the endocrinological gynaecology outpatient service of a private clinic in Lima-Peru during 2012-2014...
March 27, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29608438/seasonal-changes-in-serum-tsh-concentrations-observed-from-big-data-obtained-during-six-consecutive-years-from-2010-to-2015-at-a-single-hospital-in-japan
#15
Ai Yoshihara, Jaeduk Yoshimura Noh, Natsuko Watanabe, Kenji Iwaku, Yo Kunii, Hidemi Ohye, Miho Suzuki, Masako Matsumoto, Nami Suzuki, Kiminori Sugino, Linda M Thienpont, Akira Hishinuma, Koichi Ito
BACKGROUND: This study analyzed big data for serum thyrotropin (TSH), free triiodothyronine (fT3), and free thyroxine (fT4) concentrations in patients who had attended the outpatient clinic of Ito Hospital (Tokyo, Japan) during a recent six-year period (between January 1, 2010, and December 31, 2015) in order to investigate for seasonal changes. METHODS: The serum TSH concentrations were reviewed for all 135,417 patients aged >20 years. Patients with any thyroid diseases were included, irrespective of whether they were receiving drug therapy...
April 2, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29605463/implementation-of-thyroid-function-tests-algorithms-by-clinical-laboratories-a-four-year-experience-of-good-clinical-and-diagnostic-practice-in-a-tertiary-hospital-in-greece
#16
George Notas, Marilena Kampa, Niki Malliaraki, Maria Petrodaskalaki, Stathis Papavasileiou, Elias Castanas
INTRODUCTION: Thyroid Function Tests (TFTs) are among the most commontly ordered tests. Significant overuse of TFTs can occur when instead of using a single TSH test to screen for thyroid disease a full panel (TSH plus FT4 and FT3) is ordered. The aim of our study was to evaluate the effectiveness of the application of a scientifically-established laboratory-controlled algorithm for TFTs to physician's orders for inpatients and to address potential pitfalls of such an approach. MATERIALS AND METHODS: We collected and analyzed Laboratory Information System data of the TFTs performed between April 2009 and March 2016 in a 739-bed tertiary teaching hospital...
March 28, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29603069/higher-free-triiodothyronine-concentration-is-associated-with-lower-prevalence-of-microangiopathic-complications-and-better-metabolic-control-in-adult-euthyroid-people-with-type-1-diabetes
#17
Bogusz Falkowski, Anita Rogowicz-Frontczak, Agata Grzelka, Aleksandra Uruska, Judyta Schlaffke, Aleksandra Araszkiewicz, Dorota Zozulinska-Ziolkiewicz
PURPOSE: Type 1 diabetes mellitus (T1DM) is a disorder of insulin deficiency but with a wide range of hormones simultaneously disturbed. The study was performed to explore relation of free triiodothyronine (FT3) with metabolic control and occurrence of microangiopathic complications. METHODS: A total of 266 adult T1DM participants [56% men; 32 (interquartile range, IQR: 25-39) years and disease duration 13 (IQR: 8-19) years] in euthyroid state with negative history for hypothyroidism were included to the study...
March 30, 2018: Endocrine
https://www.readbyqxmd.com/read/29594051/vitamin-d-in-graves-disease-levels-correlation-with-laboratory-and-clinical-parameters-and-genetics
#18
Tereza Planck, Bushra Shahida, Johan Malm, Jonas Manjer
Objective: The aim was to compare the vitamin D levels in patients with Graves disease (GD) with the general population and to correlate the vitamin D levels with laboratory and clinical parameters in GD. Moreover, we examined the genetic variation in genes involved in the vitamin D metabolism and their association with GD. Methods: The levels of vitamin D were compared in 292 patients with newly diagnosed GD and 2,305 controls. Single nucleotide polymorphisms (SNPs) in the vitamin D receptor (VDR), vitamin D binding protein (DBP), and 1-α-hydroxylase ( CYP27B1 ) were examined for association with GD and/or Graves ophthalmopathy (GO) in 708 patients and 1,178 controls...
January 2018: European Thyroid Journal
https://www.readbyqxmd.com/read/29593440/graves-disease-in-central-ghana-clinical-characteristics-and-associated-factors
#19
Osei Sarfo-Kantanka, Fred Stephen Sarfo, Eunice Oparebea Ansah, Ishmael Kyei
Background: Graves disease (GD) has increased in prevalence over the past decade in Africa. Despite this, the condition is not well described, especially in sub-Saharan Africa. Objective: We have described the clinical characteristics and associated factors of GD in a cohort of patients attending a resource-limited setting tertiary hospital. Methods: Patients were examined thoroughly and systematically tested for the degree of clinical and biochemical thyroid status...
2018: Clinical Medicine Insights. Endocrinology and Diabetes
https://www.readbyqxmd.com/read/29593094/distinct-human-%C3%AE-1-3-fucosyltransferases-drive-lewis-x-sialyl-lewis-x-assembly-in-human-cells
#20
Nandini Mondal, Brad Dykstra, Jungmin Lee, David Ashline, Vernon N Reinhold, Derrick J Rossi, Robert Sackstein
In humans, six α(1,3)-fucosyltransferases (α(1,3)-FTs: FT3/FT4/FT5/FT6/FT7/FT9) reportedly fucosylate terminal lactosaminyl glycans yielding Lewis X (LeX ; CD15) and/or sialyl Lewis X (sLeX ; CD15s), structures that play key functions in cell migration, development, and immunity. Prior studies analyzing α(1,3)-FT-specificities utilized either purified and/or recombinant enzymes to modify synthetic substrates under non-physiological reaction conditions or molecular biology approaches wherein α(1,3)-FTs were expressed in mammalian cell lines, notably excluding investigations using primary human cells...
March 28, 2018: Journal of Biological Chemistry
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