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https://www.readbyqxmd.com/read/28205257/status-of-internal-quality-control-for-thyroid-hormones-immunoassays-from-2011-to-2016-in-china
#1
Shishi Zhang, Wei Wang, Haijian Zhao, Falin He, Kun Zhong, Shuai Yuan, Zhiguo Wang
BACKGROUND: Internal quality control (IQC) plays a key role in the evaluation of precision performance in clinical laboratories. This report aims to present precision status of thyroid hormones immunoassays from 2011 to 2016 in China. METHODS: Through Clinet-EQA reporting system, IQC information of Triiodothyronine and Thyroxine in the form of free and total (FT3, TT3, FT4, TT4), as well as Thyroid Stimulating Hormone (TSH) were collected from participant laboratories submitting IQC data in February, 2011-2016...
February 15, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28204898/surgical-treatment-and-outcome-of-tsh-producing-pituitary-adenomas
#2
Roman Rotermund, Nina Riedel, Till Burkhardt, Jakob Matschke, Nils-Ole Schmidt, Jens Aberle, Jörg Flitsch
BACKGROUND: Thyrotropin-producing adenomas (TSHomas) account for approximately 1-2% of all pituitary tumors. Recently, there has been debate on primary treatment as some studies suggest a high rate of hypopituitarism after transsphenoidal surgery and therefore suggest primary use of somatostatin analogs (SSA) instead. We would like to challenge this assumption by presenting our single-center experience with transsphenoidal surgery for TSHoma. METHODS: Fifteen patients treated consecutively between May 2010 and December 2016 were analyzed for long-term postoperative remission and pituitary function...
February 15, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28194837/comparison-of-thyroid-function-tests-and-blood-count-in-pregnant-women-with-versus-without-gestational-diabetes-mellitus
#3
Suheyla Gorar, Gul Babacan Abanonu, Aysel Uysal, Onur Erol, Aysun Unal, Seyit Uyar, Ayhan Hilmi Cekin
AIM: The aim of this study was to compare thyroid function and complete blood count parameters in pregnant women with versus without gestational diabetes mellitus (GDM). METHODS: A total of 269 pregnant women patients with (n = 110, GDM group) or without (n = 159, non-GDM group) GDM were included in this study. Data on age, rate of cesarean section, birthweight of neonate, hemogram, and thyroid function tests were collected. Multivariate analysis was performed to determine factors predicting increased risk of GDM...
February 13, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28194694/thyroid-status-of-iodine-deficient-newborn-infants-living-in-central-region-of-turkey-a-pilot-study
#4
Osman Bastug, Levent Korkmaz, Hulya Halis, Seyma Memur, Sabriye Korkut, Ahmet Ozdemir, Tamer Gunes, Mehmet Adnan Ozturk, Selim Kurtoglu
BACKGROUND: Iodine deficiency (ID) during the fetal and neonatal periods can lead to neonatal hypothyroidism. This study was conducted to evaluate the effect of ID on the thyroid hormone level of newborns living in Turkey. METHODS: Between 1998 and 2013, 71 newborns with a urinary iodine concentration <100 μg/L were recruited into the study. Data on thyroid volume, free triiodothyronine (fT3), free thyroxine (fT4), thyroid stimulating hormone (TSH), and thyroglobulin (Tg) were collected from all newborns, and on breast milk iodine from their mothers...
February 14, 2017: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/28190662/prospective-ultrasonographic-and-endocrine-predictors-of-spermatogenic-onset-in-ram-lambs
#5
Pawel M Bartlewski, Jennifer L Giffin, Olutobi A Oluwole, Ann C Hahnel
The objective of this study was to examine testicular ultrasonographic characteristics and endocrine profiles in prepubescent ram lambs for correlations with the age at first detection of elongated spermatids (ESt age). Bi-weekly ultrasound examinations and weekly testicular biopsies began at 10 weeks of age or at the time that testicular volume reached 15cm(3), and continued until 1-2 weeks after Est's were first detected by histological examination of testicular biopsies in twenty-two spring-born Rideau Arcott×Polled Dorset lambs...
February 6, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/28176633/hypothyroidism-and-nephrotic-syndrome-why-when-and-how-to-treat
#6
Francesca Di Mario, Riccardo Pofi, Antonietta Gigante, Laura Rivoli, Edoardo Rosato, Andrea Maria Isidori, Rosario Cianci, Biagio Barbano
Hypothyroidism, characterised by low/normal free thyroxine (FT4) and free tri-iodothyronine (FT3) with elevated thyroid-stimulating hormone (TSH), is a well-known complication of nephrotic syndrome (NS). This is a common feature of primary and secondary glomerular diseases and comprises loss of protein in the urine and increased urinary excretion of thyroid hormones and thyroxine-binding globulin. With a normal thyroid reserve, this scenario is associated with the development of subclinical hypothyroidism, with a slight increase in TSH and normal free fractions...
February 7, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28157735/an-investigation-of-extracellular-histones-in-pig-to-baboon-organ-xenotransplantation
#7
Tao Li, Whayoung Lee, Hidetaka Hara, Cassandra Long, Mohamed Ezzelarab, David Ayares, Hai Huang, Yi Wang, David K C Cooper, Hayato Iwase
BACKGROUND: Serum (extracellular) histone levels are increased in inflammatory states and in the presence of coagulation dysfunction, eg, trauma, chemical/ischemic injury, infection. There is increasing evidence of a systemic inflammatory response associated with the presence of a pig xenograft in a nonhuman primate. We evaluated extracellular histone levels in baboons with various pig xenografts. METHODS: We measured serum histones in baboons with pig heterotopic heart (n=8), life-supporting kidney (n=5), orthotopic liver (n=4), and artery patch (n=9) grafts by ELISA...
February 3, 2017: Transplantation
https://www.readbyqxmd.com/read/28151911/risk-factors-of-hepatic-dysfunction-in-patients-with-graves-hyperthyroidism-and-the-efficacy-of-131iodine-treatment
#8
Renfei Wang, Jian Tan, Guizhi Zhang, Wei Zheng, Chengxia Li
Hepatic dysfunction is often observed in patients with Graves' hyperthyroidism. The aims of this study were to investigate the risk factors for hepatic dysfunction and to analyze the efficacy of I (radioactive iodine-131) treatment. In total, 2385 patients with Graves' hyperthyroidism (478 males, 1907 females; age 42.8 ± 13.5 years) were involved in our study. Of these, 1552 cases with hepatic dysfunction received I treatment. All clinical data were retrospectively reviewed to explore the risk factors associated with hepatic dysfunction using logistic regression analysis...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28146267/low-t3-syndrome-is-a-strong-prognostic-predictor-in-diffuse-large-b-cell-lymphoma
#9
Rui Gao, Jin-Hua Liang, Li Wang, Hua-Yuan Zhu, Wei Wu, Jia-Zhu Wu, Yi Xia, Lei Cao, Lei Fan, Tao Yang, Jian-Yong Li, Wei Xu
The aim of this study was to evaluate the prognostic effect of low triiodothyronine (T3) syndrome on patients with diffuse large B cell lymphoma (DLBCL). A hundred and eighty-eight patients with detailed thyroid hormone levels at diagnosis of DLBCL were enrolled. Low T3 syndrome was defined as a low serum free T3 (FT3) level with low or normal serum free tetraiodothyronine (FT4) and thyroid stimulating hormone levels. Multivariate Cox regression analysis was used to screen prognostic factors associated with progression-free survival (PFS) and overall survival (OS)...
February 1, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28128050/patterns-of-biomarkers-in-cord-blood-during-pregnancy-and-preeclampsia
#10
Simmi Kharb, Smiti Nanda
: Umbilical cord blood (UCB) is in contact with all the fetal tissues and can reflect the state of fetus and UCB can be compared with maternal blood. Inflammatory, metabolic and immunological disorders during pregnancy can affect the environment in which the fetus is developing and may produce various alterations. OBJECTIVE: To analyze different biochemical parameters in maternal venous blood and new born umbilical cord blood from healthy normotensive pregnant and preeclamptic women...
January 25, 2017: Current Hypertension Reviews
https://www.readbyqxmd.com/read/28126204/the-relationship-between-iron-level-and-thyroid-function-during-the-first-trimester-of-pregnancy-a-cross-sectional-study-in-wuxi-china
#11
Jinyan Fu, Anqiang Yang, Jun Zhao, Yunlong Zhu, Ying Gu, Yaohui Xu, Daozhen Chen
Our objective was to evaluate the relationship between iron level and thyroid function during the first trimester of pregnancy in Eastern China. This was a hospital-based, cross-sectional observational study. A total of 1764 pregnant women were enrolled during their first trimester of gestation in Wuxi city. Serum ferritin (SF), hemoglobin (Hb), urinary iodine concentrations (UIC), thyroid-stimulating hormone (TSH), free thyroxine (FT4) and free triiodothyronine (FT3) were measured and evaluated in pregnant women...
January 22, 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/28119302/cognitive-functioning-in-coronary-artery-disease-patients-associations-with-thyroid-hormones-n-terminal-pro-b-type-natriuretic-peptide-and-high-sensitivity-c-reactive-protein
#12
Julius Burkauskas, Adomas Bunevicius, Julija Brozaitiene, Julius Neverauskas, Peter Lang, Robert Duwors, Narseta Mickuviene, Robertas Bunevicius
OBJECTIVE: To determine whether biomarkers of health such as serum levels of free triiodothyronine (fT3), total triiodothyronine (TT3), N-terminal pro-B-type natriuretic peptide (NT-proBNP), and high-sensitivity C-reactive protein (hsCRP) impact the cognitive functioning of coronary artery disease (CAD) patients. METHOD: About 278 patients were evaluated for socio-demographic and clinical risk factors as well as fT3, TT3, NT-proBNP, and hsCRP serum levels. Cognitive functioning measures included the Mini-Mental State Examination, Digit Span Test, Digit Symbol Substitution Test (DSST), and Trail Making Test A (TMTA)...
January 23, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28119248/concentrations-of-vitamin-a-e-thyroid-and-testosterone-hormones-in-blood-plasma-and-tissues-from-emaciated-adult-male-arctic-foxes-vulpes-lagopus-dietary-exposed-to-persistent-organic-pollutants-pops
#13
Tonje W Rogstad, Christian Sonne, Gro D Villanger, Øystein Ahlstøm, Eva Fuglei, Derek C G Muir, Even Jørgensen, Bjørn Munro Jenssen
The aim of the present study was to investigate the relationships and effects of oral POP exposure on retinol (vitamin A), α-tocopherol (vitamin E), thyroid hormones and testosterone in emaciated adult farmed Arctic foxes. Eight brother-pairs were exposed to either a diet containing naturally POP-contaminated minke whale blubber (Balaenoptera acutorostrata) (n=8), or a control diet containing pig (Sus scrofa) fat as the primary fat source (n=8) for 22 months. In the whale blubber containing feed the ∑POPs concentration was 802ng/g w...
January 21, 2017: Environmental Research
https://www.readbyqxmd.com/read/28114138/plasma-gelsolin-and-its-association-with-mortality-and-hospitalization-in-chronic-hemodialysis-patients
#14
Cesar Flores Gama, Laura M Rosales, Georges Ouellet, Yanna Dou, Stephan Thijssen, Len Usvyat, Hanjie Zhang, Viktoriya Kuntsevich, Nathan W Levin, Peter Kotanko
BACKGROUND: Human plasma gelsolin (pGSN) is an actin-binding protein that is secreted into the extracellular fluid, with the skeletal muscle and myocardial tissues being its major source. Depletion of pGSN has been shown to be related to a variety of inflammatory and clinical conditions. METHODS: pGSN levels were prospectively determined in prevalent maintenance hemodialysis (HD) patients from 3 U.S. dialysis centers. Demographics (age, time since dialysis initiation, race, gender, body height and weight, comorbidities), inflammatory markers (C reactive protein, CRP; interleukin 6, IL-6), free triiodothyronine (fT3), and routine laboratory parameters were obtained...
January 24, 2017: Blood Purification
https://www.readbyqxmd.com/read/28105090/effects-of-recombinant-human-growth-hormone-in-the-treatment-of-dwarfism-and-relationship-between-igf-1-igfbp-3-and-thyroid-hormone
#15
Shanxiang Ren, Yuxiang Nie, Aihong Wang
The effects of recombinant human growth hormone (rhGH) in the treatment of dwarfism and the relationship between insulin-like growth factor (IGF)-1, IGF-binding protein (IGFBP)-3 and thyroid hormone were examined in the present study. For this purpose, 66 patients diagnosed with dwarfism were selected retrospectively, with 36 cases of growth hormone deficiency (GHD) and 30 cases of idiopathic short stature (ISS). The therapeutic dose of GHD 0.10 IU/kg·day and ISS 0.15 IU/kg·day were injected subcutaneously every night before sleep until adulthood...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28097455/leptin-npy-melatonin-and-zinc-levels-in-experimental-hypothyroidism-and-hyperthyroidism-the-relation-to-zinc
#16
Abdulkerim Kasım Baltaci, Rasim Mogulkoc
Since zinc mediates the effects of many hormones or is found in the structure of numerous hormone receptors, zinc deficiency leads to various functional impairments in the hormone balance. And also thyroid hormones have important activity on metabolism and feeding. NPY and leptin are affective on food intake and regulation of appetite. The present study is conducted to determine how zinc supplementation and deficiency affect thyroid hormones (free and total T3 and T4), melatonin, leptin, and NPY levels in thyroid dysfunction in rats...
January 17, 2017: Biochemical Genetics
https://www.readbyqxmd.com/read/28090515/a-systematic-review-of-combinatorial-treatment-with-warming-and-invigorating-drugs-and-levothyroxine-for-hypothyroidism-caused-by-hashimoto-disease
#17
Xiangwen Cheng, Zixiao Wei, Guangde Zhang, Xin Shao, Bo Li, Rui Gao
BACKGROUND: We used the systematic review method to evaluate the clinical efficacy and safety of combinatorial treatment with warming and invigorating drugs and levothyroxine on hypothyroidism caused by Hashimoto thyroiditis (HT). METHODS: We set inclusion and exclusion criteria, searched for studies using electronic databases and manual retrieval, selected studies according to the inclusion and exclusion criteria, and assessed the qualities of the included studies according to the Jadad scale...
December 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28057507/association-between-thyroid-hormone-parameters-and-dyslipidemia-among-type-2-diabetes-mellitus-patients-comparative-cross-sectional-study
#18
Amare Desalegn Wolide, Belay Zawdie, Tilahun Alemayehu, Samuel Tadesse
BACKGROUND: The relationship between thyroid function and lipid profile has been documented in T2DM and healthy subjects. The aim of the current study was to assess the association between thyroid hormone parameters and dyslipidemia in T2DM and non-diabetic study participants. METHOD AND MATERIALS: In this comparative cross-sectional study, 214 type 2 diabetic and 214 non-diabetic study participants were enrolled. Clinical and anthropometric data were collected from all study participants...
December 26, 2016: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28056660/biochemical-markers-reflecting-thyroid-function-in-athyreotic-patients-on-levothyroxine-monotherapy
#19
Mitsuru Ito, Akira Miyauchi, Mako Hisakado, Waka Yoshioka, Akane Ide, Takumi Kudo, Eijun Nishihara, Minoru Kihara, Yasuhiro Ito, Kaoru Kobayashi, Akihiro Miya, Shuji Fukata, Mitsushige Nishikawa, Hirotoshi Nakamura, Nobuyuki Amino
BACKGROUND: Some investigators reported that among athyreotic patients on levothyroxine (LT4) monotherapy following total thyroidectomy, the patients with normal serum thyrotropin (TSH) levels had mildly low serum free triiodothyronine (fT3) levels, whereas the patients with mildly suppressed serum TSH levels had normal serum fT3 levels, and the patients with strongly suppressed serum TSH had elevated serum fT3 levels. The objective of the present study was to clarify which of these three patient groups is closer to their preoperative euthyroid condition...
February 6, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28046653/tu-ab-bra-05-optimization-of-a-novel-large-field-of-view-distortion-phantom-for-mr-only-treatment-planning
#20
R G Price, R A Knight, K Hwang, E Bayram, C Glide-Hurst
PURPOSE: MR-only treatment planning requires images of high geometric fidelity, particularly for large fields of view (FOV). However, the availability of large FOV distortion phantoms with accompanying analysis software is currently limited to in-house solutions. This work sought to optimize the design of a modular distortion phantom that can accommodate several bore configurations and implement distortion corrections. METHODS: 1.0T MR and CT images were acquired of twelve urethane foam samples of various densities and strengths...
June 2016: Medical Physics
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