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https://www.readbyqxmd.com/read/28417080/applying-a-systems-approach-to-thyroid-physiology-looking-at-the-whole-with-a-mitochondrial-perspective-instead-of-judging-single-tsh-values-or-why-we-should-know-more-about-mitochondria-to-understand-metabolism
#1
REVIEW
Roy Moncayo, Helga Moncayo
Classical thinking in endocrine physiology squeezes our diagnostic handling into a simple negative feedback mechanism with a controller and a controlled variable. In the case of the thyroid this is reduced to TSH and fT3 and fT4, respectively. The setting of this tight notion has no free space for any additions. In this paper we want to challenge this model of limited application by proposing a construct based on a systems approach departing from two basic considerations. In first place since the majority of cases of thyroid disease develop and appear during life it has to be considered as an acquired condition...
June 2017: BBA Clinical
https://www.readbyqxmd.com/read/28407664/fenugreek-a-potent-hypoglycaemic-herb-can-cause-central-hypothyroidism-via-leptin-a-threat-to-diabetes-phytotherapy
#2
Jayjeet Majumdar, Pratip Chakraborty, Analava Mitra, Nirmal Kumar Sarkar, Supriti Sarkar
Fenugreek (Trigonella foenum graecum), a medicinal herb with potent antihyperglycaemic and hypoglycaemic effects, is used to treat diabetes. This study is aimed to explore the interaction of fenugreek seed extract (FSE) and HPT (hypothalamic-pituitary-thyroid) axis in context of leptin secretion which have important role in normal and type-1 diabetic subjects. FSE (confirmed to contain trigonelline, diosgenin, 4 hydroxyisoleucine) was gavaged (0.25 gm/kg body weight/day) to normal and alloxan-induced type-1 diabetic rats for 4 weeks...
April 13, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28398655/seasonal-variations-in-tsh-serum-levels-in-athyreotic-patients-under-l-thyroxine-replacement-monotherapy
#3
Damiano Gullo, Adele Latina, Francesco Frasca, Sebastiano Squatrito, Antonino Belfiore, Riccardo Vigneri
BACKGROUND: Whether serum TSH undergoes seasonal fluctuations in euthyroid and hypothyroid residents of temperate climates is controversial. METHODS: Monthly TSH and thyroid hormone levels were cross-sectionally analyzed in a large cohort of euthyroid subjects (n=11,806) and L-thyroxine (L-T4)-treated athyreotic patients (n=3,934). Moreover, in a small group (n=119) of athyreotic patients treated with an unchanged dosage of L-T4 monotherapy, hormones were measured both in the coldest and the hottest seasons of the same year (longitudinal study)...
April 11, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28397723/short-term-preoperative-octreotide-for-thyrotropin-secreting-pituitary-adenoma
#4
Hong-Juan Fang, Yu Fu, Huan-Wen Wu, Yi-Lin Sun, Yang-Fang Li, Ya-Zhuo Zhang, Li-Yong Zhong
BACKGROUND: Thyrotropin-secreting pituitary adenomas (TSHomas) are a rare cause of hyperthyroidism. Somatostatin (SST) analogs work by interacting with somatostatin receptors (SSTRs). This study aimed to evaluate short-term preoperative octreotide (OCT) use in TSHoma patients and to investigate SSTR2 and SSTR5 expression and observe structural changes in tumor tissue. METHODS: We reviewed records and samples from eight TSHoma patients treated between July 2012 and July 2015...
April 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28395379/tsh-%C3%A2-2-5%C3%A2-miu-l-is-associated-with-the-increased-oxidative-damage-to-membrane-lipids-in-women-of-childbearing-age-with-normal-thyroid-tests
#5
Malgorzata Karbownik-Lewinska, Magdalena Marcinkowska, Jan Stepniak, Andrzej Lewinski
According to current recommendations, a TSH value of <2.5 mIU/l should be maintained during preconception and pregnancy. The same recommendation, however, does not relate to all women of childbearing age. The aim of the study was to evaluate relationship between lipid peroxidation (LPO; index of oxidative damage to membrane lipids) and thyroid tests and other parameters, which may be affected by thyroid dysfunction, in euthyroid women of childbearing age. Ninety nine female inpatients with normal thyroid tests (TSH 0...
April 10, 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/28395210/low-serum-thyroid-stimulating-hormone-levels-are-associated-with-lipid-profile-in-depressive-patients-with-long-symptom-duration
#6
Rui Peng, Yan Li
OBJECTIVE: The current study was designed to investigate the association between serum thyroid hormones and thyroid-stimulating hormone (TSH) levels with lipid profile in depressive disorder. METHODS: A total of 370 depressive individuals aged 18 years and above were recruited in this cross-section study. All participants underwent a Structured Clinical Interview for DSM-IV (SCID) and recorded the duration of their symptoms. The serum levels of total cholesterol (TCH), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), lipoprotein A (Lp(a)), high-sensitivity C-reactive protein (hsCRP), free thyroxine (FT4), free triiodothyronine (FT3) and TSH levels were determined and the ratios of TCH/HDL-C were assessed...
March 28, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28387076/-pediatric-reference-intervals-retrospective-study-on-thyroid-hormone-levels
#7
A Ladang, L Vranken, F Luyckx, M-C Lebrethon, E Cavalier
Defining reference range is an essential tool for diagnostic. Age and sexe influences on thyroid hormone levels have been already discussed. In this study, we are defining a new pediatric reference range for TSH, FT3 and FT4 for Cobas C6000 analyzer. To do so, we have taken in account 0 to 18 year old outclinic patients. During the first year of life, thyroid hormone levels change dramatically before getting stabilized around 3 years old. We also compared our results to those obtained in a Canadian large-scale prospective study (the CALIPER initiative)...
January 2017: Revue Médicale de Liège
https://www.readbyqxmd.com/read/28386276/cholesterol-synthesis-increased-in-the-mmi-induced-subclinical-hypothyroidism-mice-model
#8
Yongfeng Song, Xiujuan Zhang, Wenbin Chen, Ling Gao
Subclinical hypothyroidism (SCH) is defined as increased serum thyroid-stimulating hormone (TSH) concentrations and normal serum thyroid hormone (TH) levels as well as an increased serum cholesterol level, which is an important cause of secondary hypercholesterolemia and cardiovascular diseases. Some studies have demonstrated a direct effect of TSH on cholesterol metabolism via in vivo and in vitro experiments. However, because no suitable SCH model has been established until now, the changes in cholesterol synthesis that occur in SCH patients remain unknown...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28382137/evaluation-of-the-safety-and-efficacy-of-radiofrequency-ablation-for-treating-benign-thyroid-nodules
#9
Xiaoyin Tang, Dan Cui, Jiachang Chi, Zhi Wang, Tao Wang, Bo Zhai, Ping Li
Background: Radiofrequency ablation (RFA) is a relatively new procedure for treating benign thyroid nodules. The purpose of this study was to evaluate the safety and efficacy of RFA for treating benign thyroid nodules so as to serve as a reference for future clinical practice. Methods: This study retrospectively analyzed the clinical data of patients receiving percutaneous RFA for treating thyroid nodules from November 2014 to July 2015 in our medical center. One hundred and eight patients with a total of 380 nodules received ultrasound-guided RFA for treating thyroid nodules...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28376913/the-t4-t3-quotient-as-a-risk-factor-for-differentiated-thyroid-cancer-a-case-control-study
#10
Mark Sasson, Emily Kay-Rivest, Rami Shoukrun, Anca Florea, Michael Hier, Veronique-Isabelle Forest, Michael Tamilia, Richard J Payne
BACKGROUND: The incidence of thyroid nodules is increasing among patients in North America. Few of these nodules harbour malignancy, thus further research is required to identify predictive markers of malignant thyroid disease. This study set out to understand the relationship between the levels of fT4 and fT3 and differentiated thyroid cancer. METHODS: A case-control study was conducted with 142 cases and 86 controls from the McGill University Teaching Hospitals...
April 4, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28374508/free-triiodothyronine-free-thyroxine-ratio-rather-than-thyrotropin-is-more-associated-with-metabolic-parameters-in-healthy-euthyroid-adult-subjects
#11
So Young Park, Se Eun Park, Sang Won Jung, Hyun Seok Jin, Ie Byung Park, Song Vogue Ahn, Sihoon Lee
OBJECTIVE: The interrelation between TSH, thyroid hormones, and metabolic parameters is complex and has not been confirmed. This study aimed to determine the association of TSH and thyroid hormones in euthyroid subjects and the relationship between thyroid function and metabolic risk factors. Furthermore, this study examined whether thyroid function has predictive power for metabolic syndrome. DESIGN: This is a cross-sectional study that included subjects in a medical health check-up program at a single institution...
April 4, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28365926/total-and-free-iodothyronine-changes-in-response-to-transport-of-equidae-equus-asinus-and-equus-caballus
#12
Esterina Fazio, Pietro Medica, Cristina Cravana, Adriana Ferlazzo
In this study the effects of short distance road transport on total and free iodothyronine changes in 12 stallions (Equus asinus and Equus caballus) were evaluated. Donkeys (n = 6) and horses (n = 6) were transported for a distance of 50 km. Blood samples were collected 1 week before transport in basal conditions, 1 week later immediately before loading, and after transport and unloading. After transport, donkeys showed significant increases in circulating T4 (P≤0.01), fT3 (P≤0.001), and fT4 (P≤0.01) levels; while horses had significant increases in circulating T3, fT3 and fT4 (P≤0...
March 31, 2017: Veterinaria Italiana
https://www.readbyqxmd.com/read/28348902/atypical-complications-of-graves-disease-a-case-report-and-literature-review
#13
Khaled Ahmed Baagar, Mashhood Ahmed Siddique, Shaimaa Ahmed Arroub, Ahmed Hamdi Ebrahim, Amin Ahmed Jayyousi
Graves' disease (GD) may display uncommon manifestations. We report a patient with rare complications of GD and present a comprehensive literature review. A 35-year-old woman presented with a two-week history of dyspnea, palpitations, and edema. She had a raised jugular venous pressure, goiter, and exophthalmos. Laboratory tests showed pancytopenia, a raised alkaline phosphatase level, hyperbilirubinemia (mainly direct bilirubin), and hyperthyroidism [TSH: <0.01 mIU/L (reference values: 0.45-4.5), fT4: 54...
2017: Case Reports in Endocrinology
https://www.readbyqxmd.com/read/28333900/-the-influence-of-hypothyroidism-on-the-conversion-and-binding-of-thyroid-hormones-in-patients-with-end-stage-renal-disease
#14
Iwanna Dubczak, Longin Niemczyk, Zbigniew Bartoszewicz, Katarzyna Szamotulska, Marek Saracyn, Stanisław Niemczyk
Hypothyroidism in patients with renal failure (RF) causes many metabolic and clinical problems, and both these diseases can mutually exacerbate their disturbances. AIM: The aim of this study was to evaluate the effect of hypothyroidism, and end-stage renal disease (ESRD) on conversion of thyroid hormones (TH) in patients with ESRD treated with chronic hemodialysis (HD). MATERIALS AND METHODS: The study was performed in 74 patients, including 41 women (K) and 33 men (M) aged 28-83 y...
March 21, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28327686/thyroid-hormone-profile-in-patients-with-chronic-kidney-disease-a-single-centre-study
#15
S Singh, A Verma, G Aryal, S Thapa, S Khakurel, K Shrestha
BACKGROUND: Chronic kidney disease (CKD) is a global burden and now recognized as a major public health problem worldwide. Patients with CKD have alteration in thyroid hormone metabolism. This study aims to evaluate the status of thyroid hormone profile in different stages of CKD. METHODS: The cross-sectional study included 103 CKD patients attending Nephrology and Dialysis unit of KIST Medical College Teaching Hospital, Lalitpur, Nepal. Serum creatinine, free triiodothyronine (fT3), free thyroxine (fT4), and thyroid stimulating hormone (TSH) were measured...
September 2016: Journal of Nepal Health Research Council
https://www.readbyqxmd.com/read/28324063/dio2-thr92ala-reduces-deiodinase-2-activity-and-serum-t3-levels-in-thyroid-deficient-patients
#16
M G Castagna, M Dentice, S Cantara, R Ambrosio, F Maino, T Porcelli, C Marzocchi, C Garbi, F Pacini, D Salvatore
Context: A significant proportion of athyreotic LT4-treated patients experience hypothyroid-like symptoms. During LT4 replacement, levels of the active hormone triiodothyronine (T3) strictly depend on type-2-deiodinase (D2)-mediated activation of LT4. The Thr92Ala polymorphism and the 258 G/A in the DIO2 gene have been associated with various clinical conditions. Objectives: To investigate the effects of DIO2 polymorphisms in thyroid hormone homeostasis. Design: We compared the pre-surgical hormonal status of thyroidectomized LT4-treated patients who had a similar TSH level, to their post-surgery status, and analyzed their DIO2 genotype in a subgroup of 102/140 (72...
February 2, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28322754/evaluation-of-the-clsi-ep26-a-protocol-for-detection-of-reagent-lot-to-lot-differences
#17
Brooke M Katzman, Karl M Ness, Alicia Algeciras-Schimnich
BACKGROUND: Verification of new reagent lots is a required laboratory task. The Clinical and Laboratory Standards Institute (CLSI) EP26-A guideline provides a lot-to-lot verification protocol to detect significant changes in test performance. The aim of this study was to compare the performance of EP26-A with our laboratory reagent lot verification protocol. METHODS: Prospective evaluations for two reagent lots each for thyroid stimulating hormone (TSH), thyroglobulin (Tg), thyroxine (T4), triiodothyronine (T3), free triiodothyronine (fT3), and thyroid peroxidase antibody (TPOAb) were performed...
March 17, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28321241/free-triiodothyronine-in-relation-to-coronary-severity-at-different-ages-gensini-score-assessment-in-4206-euthyroid-patients
#18
Bing-Yang Zhou, Yuan-Lin Guo, Na-Qiong Wu, Cheng-Gang Zhu, Ying Gao, Ping Qing, Xiao-Lin Li, Yao Wang, Geng Liu, Qian Dong, Jian-Jun Li
OBJECTIVE: To study whether free triiodothyronine (FT3) within normal range has effects on the presence and severity of coronary artery disease (CAD) in different gender and age groups. METHODS: A total of 4206 euthyroid patients were consecutively enrolled and divided into CAD group (n = 3306) and non-CAD group (n = 900). All patients underwent coronary angiography (CAG). Gensini score (GS) was used to determine the severity of coronary artery stenosis. Severe CAD was defined as GS > 32 and mild CAD was defined as GS ≤ 32...
December 2016: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/28317625/relationship-among-pulmonary-hypertension-autoimmunity-thyroid-hormones-and-dyspnea-in-patients-with-hyperthyroidism
#19
Sayid Shafi Zuhur, Derya Baykiz, Sonat Pinar Kara, Ertan Sahin, Idris Kuzu, Gulsah Elbuken
OBJECTIVE: Previous studies have reported conflicting results regarding the mechanisms underlying the pathophysiology of pulmonary hypertension (PHT) in patients with hyperthyroidism. Therefore, in this study, we investigated the association between PHT and thyroid-stimulating hormone (TSH) receptor antibody, thyroid peroxidase antibody, thyroglobulin antibody, TSH, fT3, fT4 and dyspnea during daily activities in a large population of patients with hyperthyroidism. METHODS: A total of 129 consecutive patients with hyperthyroidism, 37 with hypothyroidism and 38 euthyroid controls were enrolled in this study...
April 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28315504/association-of-triiodothyronine-levels-with-left-ventricular-function-cardiovascular-events-and-mortality-in-hemodialysis-patients
#20
Jianjun Gao, Yongxing Xu, Deyang Kong, Lei Zhou, Huaping Jia, Boran Liang, Zhaoyan Gu
BACKGROUND: Hemodialysis (HD) patients have altered free triiodothyronine (fT3) levels. A low fT3 level is a strong and inverse mortality predictor in HD patients. However, little is known about the relationship between fT3 and left ventricular function in HD patients. METHODS: A total of 128 maintenance HD patients were enrolled in this study. A thyroid function test with blood sampling and echocardiography was conducted. Low-T3 syndrome was defined as fT3 level <3...
March 16, 2017: International Journal of Artificial Organs
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