Read by QxMD icon Read


Wen-Yao Wang, Kuo Zhang, Wei Zhao, A Martin Gerdes, Giorgio Iervasi, Yi-Da Tang
Background: Although thyroid hormone (TH) has important effects on lipid metabolism, the relationship between TH and statin responsiveness has never been investigated. We hypothesize that TH plays an important role in statin responsiveness in patients with acute myocardial infarction (AMI). Methods: Consecutive 1091 hospitalized AMI patients in Fuwai hospital (Beijing, China) were enrolled into this current study. The study population was divided into three groups based on the intensity of statin treatment: low-intensity ( n = 221), moderate-intensity ( n = 712) and high-intensity ( n = 158)...
April 2018: Journal of Geriatric Cardiology: JGC
Yuhang Ma, Shumei Li, Xiaohui Wei, Jingjing Huang, Mengyu Lai, Nian Wang, Qianfang Huang, Li Zhao, Yongde Peng, Yufan Wang
Humanin (MT-RNR2) is an endogenous polypeptide that is involved in many diseases, including T2DM. Gestational diabetes mellitus (GDM) is defined as hyperglycemia during pregnancy. The aim of this study was to evaluate serum humanin levels in women with or without GDM and to elucidate possible correlations with anthropometric parameters, metabolic parameters and the incidence of GDM. Eighty-four women with GDM and 73 control women were enrolled in this study. The clinical and biochemical parameters of all subjects were determined...
June 17, 2018: Gynecological Endocrinology
Yugui Dou, Yanling Wang, Wei Sun, Yongqin Cao, Xiaonan Zhu, Jing Zheng
OBJECTIVE: To assess the iodine nutrition and thyroid function of lactatingwomen in different iodine nutrition level of children in Gansu Province, and provide a scientific basis for iodine supplementation. METHODS: Liangzhou district( the median urinary iodine was greater than or equal to 300 g/L), Linze county( the median urinary iodine was from 200 to 299 g/L) and Huating county( the median urinary iodine was from100 to 199 g/L) were selected according to 8-10 years old children urinary iodine in2009...
January 2018: Wei Sheng Yan Jiu, Journal of Hygiene Research
Qin Shu-Lan, He Chun-Yan, He Qi, Chen Juan, Jiang Cheng-Fang, Young Charlotte Aimee, Sheng Xia, Li Zhi-Hong, Xiong Long-Xin
BACKGROUND/AIMS: Chronic renal failure (CRF) is often accompanied by increased oxidative stress and euthyroid sick syndrome (ESS). The cause of ESS is unknown, and it is unknown whether there exists a link between oxidant stress and ESS in CRF patients. Therefore, we aim to investigate oxidative stress and type 1 deiodinase (DIO1) expression, which plays the key role in the ESS in CRF patients. METHODS: In-patients with CRF were divided into the two group: Group 1 is ESS patients consisting of 60 patients with low free triiodothyronine (FT3) and Group 2 consisting of 60 patients with normal FT3...
June 7, 2018: Kidney & Blood Pressure Research
Shristi Rawal, Michael Y Tsai, Stefanie N Hinkle, Yeyi Zhu, Wei Bao, Yuan Lin, Pranati Panuganti, Paul S Albert, Ronald C W Ma, Cuilin Zhang
CONTEXT: Triiodothyronine (T3) is the biologically-active thyroid hormone involved in glucose metabolism. fT3:fT4 ratio, a marker indicating conversion of free thyroxine (fT4) to free T3 (fT3), is also implicated in glucose homeostasis. OBJECTIVE: To examine associations of fT3 and fT3:fT4 ratio with gestational diabetes (GDM). DESIGN: In a case-control study, thyroid markers (fT3, fT4, TSH) were measured and fT3:fT4 ratio was derived across four visits in pregnancy, including first (gestational weeks 10-14) and second (weeks 15-26) trimester...
June 7, 2018: Journal of Clinical Endocrinology and Metabolism
L Qiu, D C Wang, T Xu, X Q Cheng, Q Sun, Y Y Hu, H C Liu, S Y Lu, G H Yang, Z J Wang
Objective: Using clinical "big data" , to investigate the factors that affect the levels of thyroid hormones, and to explore the partitioning criteria for reference intervals (RI) of these hormones. Methods: An observation study was conducted. Information of 107 107 individuals undergoing routine physical examination in Peking Union Medical College Hospital from September 1(st,) 2013 to August 31(st,) 2016 was collected, thyroid hormone of these subjects were detected. To explore the test results distribution and differences of TSH, FT4 and FT3 by gender and age; according to the seasonal division standard of China Meteorological Administration, the study period was divided into four seasons, and the seasonal fluctuation on TSH was analyzed...
May 29, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Jianxin Xue, Lei Zhang, Zhiqiang Qin, Ran Li, Yi Wang, Kai Zhu, Xiao Li, Xian Gao, Jianzhong Zhang
RATIONALE: Thyrotoxicosis from an overdose of medicinal thyroid hormone is a condition that may be associated with a significant delay in onset of toxicity. However, limited literature is available regarding thyrotoxicosis attributed to excessive ingestion of exogenous thyroid hormone and most cases described were pediatric clinical researches. Herein, we presented the course of a patient who ingested a massive amount of levothyroxine with no obvious sympathetic excited symptoms exhibited and reviewed feasible treatment options for such overdoses...
June 2018: Medicine (Baltimore)
Susanne Fischer, Charlotte Markert, Jana Strahler, Johanna M Doerr, Nadine Skoluda, Mattes Kappert, Urs M Nater
Objective: Fatigue is a core feature of functional somatic syndromes (FSS). Fatigue is also prominent in patients with thyroid diseases, which is unsurprising given the role of the hypothalamic-pituitary-thyroid (HPT) axis in regulating physiological energy demands. Research in healthy women has shown that early life adversity is linked with alterations in the HPT axis. In view of the substantial prevalence of early life adversity in patients with FSS, our aim was to investigate whether HPT functioning is related to (a) fatigue, and (b) early life adversity in these patients...
2018: Frontiers in Physiology
V F Koehler, M Reincke, C Spitzweg
The diagnosis of hypothyroidism is primarily based on clinical signs and symptoms as well as measurement of thyroid-stimulating hormone (TSH) concentration. Subclinical hypothyroidism is characterized by elevated TSH with normal serum free thyroxine (fT4 ) and triiodothyronine (fT3 ) levels, while in manifest hypothyroidism serum fT4 and fT3 levels are reduced. Common causes of primary hypothyroidism are autoimmune thyroiditis as well as therapeutic interventions, such as thyroid surgery or radioiodine therapy...
June 5, 2018: Der Internist
Anam Tariq, Yijin Wert, Pramil Cheriyath, Renu Joshi
OBJECTIVES: Hypothyroidism results in decreased mood and neurocognition, weight gain, fatigue, and many other undesirable symptoms. The American Association of Clinical Endocrinologists, the American Thyroid Association (ATA), and The Endocrine Society recommend levothyroxine (LT4) monotherapy as the treatment for hypothyroidism; however, after years of monotherapy, some patients continue to experience impaired quality of life. Combination LT4 and synthetic liothyronine (LT3) therapy or the use of desiccated thyroid extract (DTE), has not been suggested for this indication based on short-duration studies with no significant benefits...
June 2018: Southern Medical Journal
Mustafa Şahin, Asena Gökçay Canpolat, Demet Çorapçioğlu, Uğur Canpolat, Rıfat Emral, Ali Rıza Uysal
BACKGROUND: Hyperthyroidism is associated with increased metabolic activity and thermogenesis. Irisin is a key molecule in thermogenesis and energy expenditure via adipose tissue browning. Epicardial fat was previously defined as brown-like fat. Thus, here we aimed to evaluate the association between serum irisin level and epicardial fat thickness (EFT) in patients with hyperthyroidism. METHODS: A total of 25 hyperthyroid patients and 24 age-, sex-, and BMI-matched healthy controls were enrolled...
June 4, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
Rui Peng, Wen Dai, Yan Li
The present research was carried out to observe the relationships between serum free triiothyronine (FT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH) levels and lipid profile and suicide risk in depressive subjects. Serum concentrations of albumin, total bilrubin, uric acid, total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), high-sensitivity C-reactive protein (hs-CRP), FT3, FT4 and TSH were measured in 271 patients meeting the DSM-IV criteria for major depressive disorder (202 subjects without suicidal behavior and 69 suicide attempters)...
May 24, 2018: Psychiatry Research
Yuanbin Song, Jiabei Li, Shizhu Bian, Zhexue Qin, Yaoming Song, Jun Jin, Xiaohui Zhao, Mingbao Song, Jianfei Chen, Lan Huang
Background: Low free triiodothyronine (fT3) levels are generally associated with poor prognosis in patients with heart diseases, but this is controversial and there is a lack of data about ST-elevation myocardial infarction (STEMI) in Chinese patients. Objective: To assess the association between fT3 levels and the prognosis of patients with STEMI. Methods: This was a prospective observational study of 699 consecutive patients with STEMI treated at the Xinqiao Hospital between January 1, 2013, and December 31, 2014...
2018: BioMed Research International
Ayotunde O Ale, Anthonia O Ogbera, Henry O Ebili, Olusola L Adeyemo, Taiwo O Afe
Objective: The osteoporosis in thyroid disorder has the lowest report especially in sub-Saharan Africa. This study aims to determine the prevalence, predictive factors, and characteristics of osteoporosis in hyperthyroid patients. Method: Forty (40) hyperthyroid patients and healthy controls ages 21-50 years were recruited in this study. Questionnaires were administered to capture bio- and clinical data. Biochemical tests included blood, thyroid functions, intact parathyroid hormone, corrected calcium, and 25-hydroxyvitamin D tests...
2018: International Journal of Endocrinology
Silvia Vezzani, Elisa Giannetta, Barbara Altieri, Arcangelo Barbonetti, Giuseppe Bellastella, Rosaria Certo, Angelo Cignarelli, Francesca Cinti, Settimio D'Andrea, Giulia Di Dalmazi, Stefano Frara, Silvia Garelli, Giuseppe Giuffrida, Maria Ida Maiorino, Chiara Mele, Teresa Mezza, Maria Grazia Pani, Maria Teresa Samà, Chiara Satta, Daniele Santi
OBJECTIVE: The adherence by endocrinologists to guideline regarding levothyroxine (LT4) therapy and the compliance of patients may impact the management of hypothyroidism. The aim of this study was to compare the adherence of Italian endocrinologists to the ATA/AACE and ETA guidelines on the management of newly diagnosed primary hypothyroidism and to validate the Italian version of the Morisky-Green Medical Adherence Scale-8 (MMAS-8) questionnaire as applied to the evaluation of the adherence of patients with hypothyroidism to LT4 treatment...
May 2018: Endocrine Practice
Graziano Ceresini, Michela Marina, Fulvio Lauretani, Marcello Maggio, Maria Francesca Serra, Tiziana Meschi, Stefania Bandinelli, Gian Paolo Ceda, Luigi Ferrucci
BACKGROUND: Thyroid hormone variation may be correlated with adverse health outcomes, even within the normal reference range in euthyroid individuals. AIMS: To determine the association between plasma thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4) levels and physical performance score in middle age and older adults who had levels of all three hormones in the normal range. METHODS: In this community-based, cross-sectional study, euthyroid participants of the Invecchiare in Chianti study, aged 23-102 years (N = 1060), were considered...
May 29, 2018: Aging Clinical and Experimental Research
Leo Lam, Warwick Bagg, Geoff Smith, Weldon Chiu, Martin James Middleditch, Julie Ching-Hsia Lim, Campbell Vance Kyle
BACKGROUND: Exclusion of analytical interference is important when there is discrepancy between clinical and laboratory findings. However, interferences on immunoassays are often mistaken as isolated laboratory artefacts. We characterized and report the mechanism of a rare cause of interference in two patients that caused erroneous thyroid function tests, and also affects many other biotin dependent immunoassays. PATIENT FINDINGS: Patient 1 was a 77 y female with worsening fatigue while taking carbimazole over several years...
May 29, 2018: Thyroid: Official Journal of the American Thyroid Association
Wei Qiang Yang, Qian Yang, Wan Jun Chen, Xiao Bin Zhang, Qing Qing Xu, Yun Qiao, Xin Hui Xu, Li Liu, Xiao Ye Lu, Chang Qing Zhu
OBJECTIVES: To investigate the relationship between serum levels of thyroid hormone (TH) and disease severity in the early stage of acute pancreatitis (AP). METHODS: Cohort data from 172 patients with AP in the Emergency Department of Ren Ji Hospital from 2013 to 2017 were retrospectively analyzed. The patients were categorized into the groups based on severity criteria: 1) a mild AP (MAP) group, 2) a moderately severe AP (MSAP) group, and 3) a severe AP (SAP) group...
May 26, 2018: Journal of Digestive Diseases
Brittany Begaye, Paolo Piaggi, Marie S Thearle, Kaitlyn Haskie, Mary Walter, Mathias Schlögl, Susan Bonfiglio, Jonathan Krakoff, Karyne L Vinales
Context: In healthy adults with detectable cold-induced brown fat activation (CIBA), the relationships between sympathetic nervous system (SNS) or thyroid activity during energy balance (EBL) with CIBA and body composition change are undetermined. Objective: To investigate the relationships between CIBA and thermoneutral catecholamines and thyroid hormones measured during EBL and to determine if CIBA, catecholamines, or thyroid hormones predict body composition changes...
May 16, 2018: Journal of Clinical Endocrinology and Metabolism
Ann M Vuong, Joseph M Braun, Glenys M Webster, R Thomas Zoeller, Andrew N Hoofnagle, Andreas Sjödin, Kimberly Yolton, Bruce P Lanphear, Aimin Chen
BACKGROUND: Polybrominated diphenyl ethers (PBDEs) reduce serum thyroid hormone concentrations in animal studies, but few studies have examined the impact of early-life PBDE exposures on thyroid hormone disruption in childhood. METHODS: We used data from 162 mother-child pairs from the Health Outcomes and Measures of the Environment Study (2003-2006, Cincinnati, OH). We measured PBDEs in maternal serum at 16 ± 3 weeks gestation and in child serum at 1-3 years...
August 2018: Environment International
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"