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https://www.readbyqxmd.com/read/29453818/the-association-between-thyroid-function-and-incidence-of-metabolic-syndrome-in-euthyroid-subjects-tianjin-chronic-low-grade-systemic-inflammation-and-health-cohort-study
#1
Yeqing Gu, Yanyan Wang, Qing Zhang, Li Liu, Ge Meng, Zhanxin Yao, Hongmei Wu, Yang Xia, Xue Bao, Hongbin Shi, Honglei Wang, Shaomei Sun, Xing Wang, Ming Zhou, Qiyu Jia, Kun Song, Kaijun Niu
OBJECTIVE: Thyroid hormones (THs) are primarily responsible for the regulation of energy homeostasis and metabolism. However, few prospective studies have assessed the association between THs and metabolic syndrome (MetS) in a general population. We therefore designed a cohort study to examine whether serum THs levels within the reference range are predictive factors for developing MetS in adults. DESIGN: Prospective cohort study. PARTICIPANTS: A prospective study (n=6,119) was performed in Tianjin, China...
February 17, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29442475/association-of-heterogeneity-of-the-thyroid-gland-with-matrix-metalloproteinase-3-in-rheumatoid-arthritis-patients-with-hashimoto-s-thyroiditis
#2
Toshiki Nagasaki, Yuki Nagata, Yosuke Wakita, Shinsuke Yamada, Hitoshi Goto, Yasuo Imanishi, Naoyoshi Onoda, Masanori Emoto, Masaaki Inaba
PURPOSE: Hashimoto's thyroiditis (HT) is highly prevalent in patients with rheumatoid arthritis (RA). The aim is to determine their relation, focusing on matrix metalloproteinase-3 (MMP-3), a marker predicting joint destruction and RA activity. METHODS: Fifty three consecutive RA patients were prospectively separated into two groups on the basis of the presence or absence of HT; those with and without TPO-Ab or Tg-Ab (34.0% and 66.0%, respectively). To estimate the extent of inflammation and destruction of the thyroid gland, heterogeneity index (HI) was determined ultrasonographically...
February 13, 2018: Minerva Endocrinologica
https://www.readbyqxmd.com/read/29433018/interaction-between-deca-bde-and-hepatic-deiodinase-in-a-highly-pbde-exposed-bird
#3
Anthony François, Jonathan Verreault
Studies have shown that debromination of the major component in the deca-brominated diphenyl ether mixture (deca-BDE), BDE-209, occurs in vivo in birds. Recent work from our laboratory on breeding ring-billed gulls (Larus delawarensis) exposed to elevated PBDE concentrations in the densely-populated metropolis of Montreal (Canada) further suggests that BDE-209 debromination is potentially catalyzed by deiodinases in liver microsomes. The first objective of this study was to determine if type 1 deiodinase (D1) was involved in the in vitro debromination of BDE-209 in liver microsomes of ring-billed gulls...
February 9, 2018: Environmental Research
https://www.readbyqxmd.com/read/29428703/the-contribution-of-total-and-free-iodothyronines-to-welfare-maintenance-and-management-stress-coping-in-ruminants-and-equines-physiological-ranges-and-reference-values
#4
REVIEW
Adriana Ferlazzo, Cristina Cravana, Esterina Fazio, Pietro Medica
In order to acquire a pattern of thyroid involvement in welfare maintenance in Ruminants and Equines, this review summarizes data concerning the reference values of total and free iodothyronines and their modifications in physiological conditions and in different management conditions (pregnancy, lactation, weaning, growth, isolation, restraint, shearing, confinement and transportation). Thyroidal and extrathyroidal tissues efficiently respond to management practices, giving a differentiated contribution to circulating iodothyronine changes...
February 2, 2018: Research in Veterinary Science
https://www.readbyqxmd.com/read/29427748/the-non-thyroidal-illness-syndrome-is-associated-with-postoperative-surgical-site-infections-in-enterocutaneous-fistulae
#5
Huajian Ren, Jianan Ren, Gefei Wang, Zhiwu Hong, Guosheng Gu, Jun Chen, Xiuwen Wu, Qiongyuan Hu, Guanwei Li
BACKGROUND: Non-thyroidal illness syndrome (NTIS) is common in critically ill patients and associated with adverse outcomes. Many enterocutaneous fistula (ECF) patients still suffer NTIS prior to definitive surgery. This study was designed to explore the association between preoperative NTIS and postoperative outcomes in ECF patients. METHODS: A total of 264 ECF patients who underwent definitive surgery from April 2014 to November 2016 were studied. Thyroid hormones were tested for each patient before surgery, and the patients were divided into two groups (NTIS group and euthyroid group) according to the presence of NTIS...
February 7, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29422822/thyroid-function-and-thyroid-autoantibodies-in-patients-with-chronic-spontaneous-urticaria
#6
Magdalena Czarnecka-Operacz, Anna Sadowska-Przytocka, Dorota Jenerowicz, Anna Szeliga, Zygmunt Adamski, Katarzyna Łącka
Introduction: Chronic urticaria (CU) is a skin disease caused by autoantibodies against high affinity immunoglobulin E (IgE) receptor and against IgE. It is characterized by hives, erythematous wheals and redness present minimum twice a week for at least 6 weeks. It is observed that there is a strong association between CU and autoimmune diseases, such as autoimmune thyroiditis (AT). Aim: To verify the frequency of AT in patients suffering from chronic spontaneous urticaria (CSU) and to confirm the coexistence of CU and AT in the Polish population...
December 2017: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/29409581/endocrine-disruption-activity-of-30-day-dietary-exposure-to-decabromodiphenyl-ethane-in-balb-c-mouse
#7
Ru Bao Sun, Shuai Shang, Wei Zhang, Ben Cheng Lin, Qiang Wang, Yun Shi, Zhu Ge Xi
OBJECTIVE: This study aimed to evaluate the hepatotoxicity, metabolic disturbance activity and endocrine disrupting activity of mice treated by Decabromodiphenyl ethane (DBDPE). METHODS: In this study, Balb/C mice were treated orally by gavage with various doses of DBDPE. After 30 days of treatment, mice were sacrificed; blood, livers and thyroid glands were obtained, and hepatic microsomes were isolated. Biochemical parameters including 8 clinical chemistry parameters, blood glucose and hormone levels including insulin and thyroid hormone were assayed...
January 2018: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29408972/subclinical-hypothyroidism-and-incident-depression-in-young-and-middle-age-adults
#8
Ji Sun Kim, Yiyi Zhang, Yoosoo Chang, Seungho Ryu, Eliseo Guallar, Young-Chul Shin, Hocheol Shin, Se-Won Lim, Juhee Cho
Background: The role of subclinical hypothyroidism in the development of depression remains controversial. We examined the prospective association between subclinical hypothyroidism and incident depressive symptoms. Methods: We conducted a prospective cohort study in 220,545 middle age adults without depression who underwent at least 2 comprehensive health exams between January 1, 2011 and December 31, 2014. Thyroid-stimulating hormone (TSH), free triiodothyronine (FT3) and free thyroxin (FT4) levels were measured by an electrochemiluminescent immunoassay...
February 2, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29406821/effect-of-goiter-dispersion-formula-on-serum-cytokines-in-hyperthyroidism-patients-with-neurologic-manifestations-of-graves-disease-a-randomized-trial-on-80-cases
#9
Wen-Hong Tian, Ying Wang, Rui Yang, Hai-Bing Hu
PURPOSE: This study is aimed to explore the combined use of goiter dispersion formula and antithyroid drugs in the treatment of patients with neurologic manifestations of Graves' disease by examining its modulating effects on patients' cytokines. METHODS: A total of 80 patients with Graves' disease were randomly divided into treatment and control groups. Patients of the treatment group received goiter dispersion formula and antithyroid drugs (methimazole or propylthiouracil), whereas those of the control group received antithyroid drug alone...
February 6, 2018: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/29396968/symptomatic-relief-is-related-to-serum-free-triiodothyronine-concentrations-during-follow-up-in-levothyroxine-treated-patients-with-differentiated-thyroid-cancer
#10
Rolf Larisch, John E M Midgley, Johannes W Dietrich, Rudolf Hoermann
AIM: Patients on levothyroxine-treatment frequently have complaints although TSH is within the reference range. Moreover, FT3 is often low in these patients. The clinical significance of this disequilibrium is studied here. PATIENTS, METHODS: We conducted a retrospective longitudinal study including 319 patients with differentiated thyroid carcinoma on LT4-medication (1.8 [1.6,2.1] µg/kg body weight). Patients were followed at 2309 visits for at median 63 [46,81] months...
February 2, 2018: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/29385933/gestational-impaired-glucose-tolerance-gigt-induced-suppression-of-fetal-thyroid-secretion-effect-on-fetal-outcome
#11
Suganya Shanmugam, Pooja Dhiman, Soundravally Rajendiran, Archana Nimesh, Dilip Kumar Maurya
INTRODUCTION: Gestational impaired glucose tolerance (GIGT) is a milder form of gestational diabetes mellitus (GDM), which is often poorly managed. Although, GDM is known to be associated with increased incidence of thyroid dysfunction, no study has been done to study the effect of GIGT on thyroid status and its effect on fetal outcome. Here, we carried out a study to assess thyroid function and glycemic status in both maternal and cord blood of the subjects with GIGT, and to find their association with the fetal outcome...
January 31, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29376496/shift-from-levothyroxine-tablets-to-liquid-formulation-at-breakfast-improves-quality-of-life-of-hypothyroid-patients
#12
Rinaldo Guglielmi, Franco Grimaldi, Roberto Negro, Andrea Frasoldati, Irene Misischi, Filomena Graziano, Claudia Cipri, Edoardo Guastamacchia, Vincenzo Triggiani, Enrico Papini
BACKGROUND: Until recently, treatment of hypothyroidism has been accomplished using monotherapy of synthetic L-thyroxine (L-T4) sodium tablets that should be taken 30-60 minutes before breakfast. Nowadays, a liquid preparation of levothyroxine is available and can effectively replace tablets without the need of waiting before having breakfast. Evidence of Quality of life (QoL) improvement when shifting from the former to the latter preparation, however, are still lacking. OBJECTIVE: To assess changes in QoL of hypothyroid patients dissatisfied of their therapy with L-T4 sodium tablets who were switched from tablets taken 30-60 minutes before breakfast to liquid L-T4 at breakfast...
January 25, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29374417/-thyroid-dysfunction-in-patients-with-small-intestinal-bacterial-overgrowth
#13
Paulina Konrad, Jan Chojnacki, Aleksandra Kaczka, Monika Pawłowicz, Cezary Rudnicki, Cezary Chojnacki
Small intestinal bacterial overgrowth (SIBO), similarly as thyroid diseases, is characterized by chronic diarrhea or constipation, but it is not known whether there is a causal relationship between these disorders. AIM: The aim of the study was to assess thyroid function indices in different clinical forms of SIBO. MATERIALS AND METHODS: The study was performed in 34 patients with diarrhea predominant SIBO (group I), 30 with constipation predominant SIBO (group II) and 30 clinically healthy subjects (control group - K)...
January 23, 2018: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29371337/endocrine-and-metabolic-evaluation-of-classic-klinefelter-syndrome-and-high-grade-aneuploidies-of-sexual-chromosomes-with-male-phenotype-are-they-different-clinical-conditions
#14
Matteo Spaziani, Mileno Benedetta, Fabio Rossi, Simona Granato, Natascia Tahani, Antonella Anzuini, Andrea Lenzi, Antonio F Radicioni
OBJECTIVE: Klinefelter Syndrome (KS) is the most common sex chromosome aneuploidy in males. As well as classic KS, less frequent higher-grade aneuploidies (HGAs) are also possible. While KS and HGAs both involve testicular dysgenesis with hypergonadotropic hypogonadism, they differ in many clinical features. The aim of this study was to investigate the endocrinal and metabolic differences between KS and HGAs. DESIGN: Cross-sectional, case-control study. METHODS: 88 patients with KS, 24 with an HGA and 60 healthy controls...
January 25, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29369370/evaluation-of-qt-dispersion-and-tp-e-interval-in-children-with-subclinical-hypothyroidism
#15
Alper Akın, Edip Unal, Ruken Yıldırım, Mehmet Türe, Hasan Balık, Yusuf Kenan Haspolat
BACKGROUND: Studies on adults, have shown increased dispersion of QT and corrected QT (cQT), peak-to-end interval of the T wave (Tp-e), Tp-e/QT ratio and Tp-e/QTc ratio in subclinical hypothyroidism (SH), but there have been no paediatric studies MATERIALS AND METHODS: A total of 40 SH patients were compared with 40 healthy children in respect of serum thyroid stimulating hormone (TSH), serum free level of triiodothyronine (fT3) and free level of thyroxine (fT4). SH diagnosis was accepted as TSH above the laboratory accepted upper limit (> 4...
January 25, 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29360143/long-term-prognostic-value-of-combined-free-triiodothyronine-and-late-gadolinium-enhancement-in-nonischemic-dilated-cardiomyopathy
#16
Kuo Zhang, Wenyao Wang, Shihua Zhao, Stuart D Katz, Giorgio Iervasi, A Martin Gerdes, Yi-Da Tang
BACKGROUND: Thyroid dysfunction and myocardial fibrosis are both associated with cardiovascular events in patients with dilated cardiomyopathy (DCM). HYPOTHESIS: The combination of thyroid hormone (TH) and myocardial fibrosis (detected by late gadolinium enhancement [LGE]) is an independent and incremental predictor of adverse events in DCM. METHODS: We consecutively enrolled 220 idiopathic DCM patients with thyroid function and LGE assessment at Fuwai Hospital (China) from January 2010 to October 2011 and followed up through December 2015...
January 23, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29336230/alterations-of-global-dna-methylation-and-dnmt-expression-in-t-and-b-lymphocytes-from-patients-with-newly-diagnosed-aitd-after-treatment-a-follow-up-study
#17
Qingling Guo, Dan Wu, Huixin Yu, Jiandong Bao, Shiqiao Peng, Zhongyan Shan, Haixia Guan, Weiping Teng
BACKGROUND: Dysregulated DNA methylation in lymphocytes has been linked to autoimmune disorders. The aims of this study were to identify global DNA methylation patterns in patients with autoimmune thyroid diseases (AITDs) and to observe methylation changes after treatment for these conditions. METHODS: We conducted a cross-sectional study design including the following patients: 51 with newly diagnosed Graves' disease (GD), 28 with autoimmune hypothyroidism (AIT), 29 with positive thyroid autoantibodies (pTAb) and 39 matched healthy volunteers...
January 16, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29322709/study-of-association-of-thyroid-hormone-in-pre-eclampsia-and-normal-pregnancy
#18
L Harshvardhan, S S Dariya, Aradhana Sharma, Lalita Verma
Aim: The aim of the study was to assess association of thyroid hormone in preeclampsia and normal pregnancy. Material and Method: This was a hospital based observational case control study. Total 100 women were included, out of them 50 normal pregnant women in control group and 50 pre-eclamptic women in case group were included. Result: In this study no significant difference was found in FT3 (p value 0.085) and FT4 (p value 0.065) in control and case group...
November 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/29321381/association-between-genetic-polymorphism-and-levothyroxine-bioavailability-in-hypothyroid-patients
#19
Merve Arici, Ezgi Oztas, Fatih Yanar, Nihat Aksakal, Beyza Ozcinar, Gul Ozhan
Thyroid hormones play a vital role in the human body for growth and differentiation, regulation of energy metabolism, and physiological function. Hypothyroidism is a common endocrine disorder, which generally results from diminished normal circulating concentrations of serum thyroxine (fT4) and triiodothyronine (fT3). The primary choice in hypothyroidism treatment is oral administration of levothyroxine (L-T4), a synthetic T4 hormone, as approximately 100-125 μg/day. Generally, dose adjustment is made by trial and error approach...
January 11, 2018: Endocrine Journal
https://www.readbyqxmd.com/read/29320782/thyroid-hormone-status-in-overweight-children-with-attention-deficit-hyperactivity-disorder
#20
Christian Langrock, Johannes Hebebrand, Katharina Radowksi, Eckard Hamelmann, Thomas Lücke, Martin Holtmann, Tanja Legenbauer, Börge Schmidt, Mirjam Frank, Karl-Heinz Jöckel, Thomas Reinehr
BACKGROUND: There is an ongoing discussion whether thyroid hormones are involved in the development and course of attention deficit/hyperactivity disorder (ADHD). Since obesity is associated with both higher thyroid-stimulating hormone (TSH) and free triiodothyronine (fT3) concentrations and increased rates of ADHD, we hypothesized that overweight children with ADHD show higher TSH and fT3 concentrations compared to overweight children without ADHD. METHODS: TSH, fT3, fT4, and leptin levels were analyzed in 230 children (60...
January 10, 2018: Hormone Research in Pædiatrics
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