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Carcinoma vagina

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https://www.readbyqxmd.com/read/27866418/microinvasive-squamous-carcinoma-of-neovagina-created-with-peritoneal-flap-davidov-case-report-and-literature-review
#1
Albert Reyes Claret, Ángel Martín Jiménez, Ana Alicia Robles Gourley, Javier Maria Ibarra de la Rosa, Margalida Vicens Vidal
Carcinoma of the vagina is a rare disease, and it is even more rare when it appears in a neovagina, having its incidence and optimum treatment constantly discussed. The aim of this article was to review the cases described in the currently available literature and describe the second documented case of carcinoma in a neovagina created with peritoneal flaps, and also list the possible pathways and risk factors for its development. The case we present is a 49-year-old female who after undergoing a laparoscopic colpectomy of the upper two-thirds of the vagina, with an immediate reconstruction with peritoneal flaps by laparoscopy, at a 4 months follow up presented a focal microinvasive squamous carcinoma in the vault of the neovagina...
November 21, 2016: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/27856389/mini-laparoscopy-of-removal-partial-adnexae-at-the-time-of-hysterectomy
#2
António Gutierrez Setúbal, João Sequeira Alves, Olga Lavado, Joana Faria
STUDY OBJECTIVE: To describe our technique of mini laparoscopic adnexectomy or salpingectomy at the time of total laparoscopic hysterectomy DESIGN: Step-by-step video explanation of our technique SETTING: The advantages of laparoscopic surgery have been widely recognised in the past two decades: improved vision, exposure, reduction in operative trauma because of smaller incisions and more gentle tissue´s handling, that result in a faster postoperative recovery. The technology development has allowed the use of smaller caliber instruments while maintaining the high standard surgical performance...
November 14, 2016: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27832422/radiation-induced-lichen-sclerosus-of-the-vulva-first-report-in-the-medical-literature
#3
Lisa R Edwards, Emily D Privette, James W Patterson, Georgi Tchernev, Anastasiya Atanasova Chokoeva, Uwe Wollina, Torello Lotti, Barbara B Wilson
A 67-year-old woman presented with a firm plaque in the perineal region, 16 months after diagnosis of a high-grade basaloid squamous cell carcinoma of the vagina and treatment by external beam radiation therapy and vaginal cuff brachytherapy. The differential diagnosis included radiation-induced morphea, radiation dermatitis, or, possibly, radiation-induced lichen sclerosus. Biopsy findings, including special staining, confirmed the diagnosis of radiation-induced lichen sclerosus. To our knowledge, this is the first report of radiation-induced lichen sclerosus of the vulvar region...
November 10, 2016: Wiener Medizinische Wochenschrift
https://www.readbyqxmd.com/read/27801758/metastatic-urothelial-carcinoma-to-the-uterine-cervix-a-case-report-of-a-rare-entity-and-review-of-the-diagnostic-differential
#4
Sharon B Sams, Julie A Rosser
Urothelial carcinoma (UC) rarely metastasizes to the gynecologic tract, occurring in descending order of frequency, within the vagina, uterus, ovaries, and cervix. Significant morphologic overlap exists between primary gynecologic squamous lesions (both benign and malignant) and metastatic UC, thus potentially hindering a timely and accurate diagnosis. We present a case of UC metastatic to the uterine cervix in a 69-year-old female initially found to have noninvasive high-grade papillary UC of the bladder. Complaints of vaginal spotting lead to identification and biopsy of a mass in the uterine cervix...
October 31, 2016: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/27745919/fluorescence-assisted-sentinel-snd-and-pelvic-node-dissections-by-single-port-transvaginal-laparoscopic-surgery-for-the-management-of-an-endometrial-carcinoma-ec-in-an-elderly-obese-patient
#5
Eric Leblanc, Fabrice Narducci, Lucie Bresson, Delphine Hudry
OBJECTIVE: To explore the feasibility of an oncologically acceptable management for an intermediate-risk endometrial cancer (EC) in an elderly, using the combination of transvaginal single-port laparoscopy and sentinel node policy. METHODS: For this 85-years old patient, BMI 32kg/m(2), with IB grade 2 endometrioid EC, a single vaginal approach was attempted [1] to perform a total hysterectomy, bilateral salpinago-oophorectomy and pelvic node assessment guided by SND [2]...
December 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27672265/human-papillomavirus-and-gastrointestinal-cancer-a-review
#6
REVIEW
Dania Bucchi, Fabrizio Stracci, Nicola Buonora, Giuseppe Masanotti
Human papillomavirus (HPV) is one of the most common sexually transmitted infections worldwide. Exposure to HPV is very common, and an estimated 65%-100% of sexually active adults are exposed to HPV in their lifetime. The majority of HPV infections are asymptomatic, but there is a 10% chance that individuals will develop a persistent infection and have an increased risk of developing a carcinoma. The International Agency for Research on Cancer has found that the following cancer sites have a strong causal relationship with HPV: cervix uteri, penis, vulva, vagina, anus and oropharynx, including the base of the tongue and the tonsils...
September 7, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27631522/yolk-sac-tumor-in-extragonadal-pelvic-sites-still-a-diagnostic-challenge
#7
Sanjita Ravishankar, Anais Malpica, Preetha Ramalingam, Elizabeth D Euscher
We present the clinicopathologic features of 15 cases of extragonadal yolk sac tumor (EGYST) detected in female patients and reviewed at our institution from 1988 to 2016. We recorded: patient age, clinical presentation, tumor location, FIGO stage (where applicable), histologic patterns including presence/absence of Schiller-Duval bodies, other germ cell or somatic components, immunoperoxidase results, treatment, and outcome. Patients' ages ranged from 17 to 87 (median, 62) years and presentation included: abnormal uterine bleeding, 12; hematuria, 1; labial mass, 1; abdominal pain, 1...
September 14, 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27602160/bladder-and-vaginal-transitional-cell-carcinoma-a-case-report
#8
Fouad Aoun, Hampig Raphael Kourie, Elie El Rassy, Roland van Velthoven
The involvement of the female genital tract in transitional cell carcinoma (TCC) has not been fully elucidated in women, although involvement is usually associated with a poor prognosis. The vagina, in particular, is considered to be the most commonly affected gynecological organ, with an incidence of 4% of total TCC cases. The pathogenesis of vaginal TCC is challenging to determine, although it is essential for the adequate management of the tumor and to determine the appropriate treatment. The present study reports a case of bladder TCC and metachronous vaginal TCC...
September 2016: Oncology Letters
https://www.readbyqxmd.com/read/27550405/carcinoma-of-the-cervix-in-elderly-patients-treated-with-radiotherapy-patterns-of-care-and-treatment-outcomes
#9
Ming Yin Lin, Srinivas Kondalsamy-Chennakesavan, David Bernshaw, Pearly Khaw, Kailash Narayan
OBJECTIVE: The aim of this analysis was to examine the management of cervix cancer in elderly patients referred for radiotherapy and the results of treatment in terms of overall survival (OS), relapse-free survival (RFS), and treatment-related toxicities. METHODS: Patients were eligible if they were aged ≥75 years, newly diagnosed with cervix cancer and referred for radiotherapy as part of their treatment. Patient details were retrieved from the gynaecology service database where clinical, histopathological treatment and follow-up data were prospectively collected...
November 2016: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/27544563/bladder-cancer-will-grow-anywhere-report-of-a-urothelial-carcinoma-drop-metastasis-to-the-vagina-and-literature-review
#10
Matthew A Uhlman, Mark D Bevill, Michael J Goodheart, James A Brown, Michael A O'Donnell
Urothelial carcinoma is the 2nd most common cancer of the urinary tract and accounts for the majority of cases of bladder cancer. Metastases are not infrequently encountered, increasing with disease stage and are most commonly seen in the bones and lungs. Many other sites have been described including the omentum, liver, and ovaries. An extremely rare site of metastatic disease however is within the vagina. Here we present a case of a probable vaginal 'drop metastasis' from previously treated urothelial carcinoma in the ureter and bladder...
August 2016: Canadian Journal of Urology
https://www.readbyqxmd.com/read/27527897/long-term-outcomes-using-adjuvant-pelvic-intensity-modulated-radiation-therapy-imrt-for-endometrial-carcinoma
#11
Siping He, Beant S Gill, Dwight E Heron, Joseph L Kelley, Paniti Sukumvanich, Alexander B Olawaiye, Robert P Edwards, John Comerci, Sushil Beriwal
PURPOSE: We evaluated the long-term outcome and toxicity of adjuvant intensity modulated radiation therapy (IMRT) for high-risk endometrial carcinoma via a retrospective institutional review of patients treated in this setting with extended follow-up. METHODS AND MATERIALS: Patients with endometrial cancer who underwent comprehensive surgical staging followed by adjuvant IMRT with or without sequential chemotherapy between 1999 and 2010 were reviewed. Median doses delivered with IMRT and brachytherapy were 45 Gy in 25 fractions and 10 Gy in 2 fractions; 10...
June 15, 2016: Practical Radiation Oncology
https://www.readbyqxmd.com/read/27522713/-melanoma-and-human-papillomaviruses-is-there-an-outlook-for-study
#12
REVIEW
G M Volgareva, I N Mikhaylova, D A Golovina
Melanoma is one of the most aggressive human malignant tumors. Its incidence and mortality are growing steadily. Ultraviolet irradiation is the main risk factor for melanoma involved in melanomagenesis. The probability of viral etiology of melanoma has been discussed. Human papillomaviruses (HPV) have been mentioned among candidates for its etiologic agents because some HPV types are the powerful carcinogens causing cervical cancer and other cancers. The review analyses the literature data on the association of melanoma with HPV Several groupsfound HPVin skin melanomas as well as in mucosa; viruses of high oncogenic risk were detected in some cases...
2016: Vestnik Rossiĭskoĭ Akademii Meditsinskikh Nauk
https://www.readbyqxmd.com/read/27513078/extrauterine-placental-site-trophoblastic-tumor-involving-the-vagina
#13
Mayank Gupta, Kiruthiga K Gnanasekaran, Ramani Manojkumar, Anitha Thomas, Ajit Sebastian
Very few cases of placental site trophoblastic tumor (PSTT) primarily involving the extrauterine sites have been reported to date. We report a case of a 29-year-old female who presented with a vaginal nodule 9 months after delivery at an outside hospital which was initially diagnosed as a poorly differentiated squamous cell carcinoma. Subsequently she was referred to our institute and on the basis of histology, mildly elevated serum β-HCG level, and immunohistochemistry, PSTT was diagnosed. After the completion of chemotherapy, the vaginal nodule completely regressed and serum β-hCG returned to the baseline...
August 10, 2016: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/27486279/role-of-pet-ct-scan-in-gynaeconcology
#14
Ashwini A Pawar, Digvijay B Patil, Shilpa Patel, Meeta Mankad, Pariseema Dave
THE PURPOSE OF THIS STUDY: This study was undertaken to evaluate the role of positron emission tomography-CT (PET-CT) in diagnosis and management of gynecological malignancies in primary and recurrent settings and also to investigate its role in inappropriately treated patients, for pretreatment evaluation (staging) to help in proper therapeutic management. METHOD: This is a retrospective study of 56 patients of gynecological malignancy registered in Gujarat Cancer Research Institute from June 2011 to December 2013...
October 2016: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/27464870/an-unexpected-reason-for-elevated-human-chorionic-gonadotropin-in-a-young-woman-cervical-squamous-carcinoma
#15
Aynur Mustafa, Zehra Bozdag, Neslihan B Tepe, Husiyen C Ozcan
Human chorionic gonadotropin has been used for decades, in addition to specific investigations, to detect pregnancy, trophoblastic tumors, as well as congenital defects. Rarely, it can be elevated in  non-trophoblastic tumors such as squamous cell cancers and germ cell tumors. A 33-year-old Asian Syrian female had irregular menses accompanied with feelings of heaviness in the vagina. In addition to routine investigations, we measured the serum beta human chorionic gonadotropin (ß-HCG) level (based on the patient's complaint of amenorrhea), which was 50...
August 2016: Saudi Medical Journal
https://www.readbyqxmd.com/read/27390216/extramammary-paget-s-disease-mimicking-localized-malignancy-on-cervical-cytology
#16
Georgina Davis, Lyndal Anderson, Selvan Pather
A case of Extramammary Paget's Disease (EMPD) involving the cervix mimicking cervical carcinoma on routine cervical cytology in a 66-year-old woman with a history of recurrent multifocal EMPD involving the vulva, perineum, perianal area, and rectum is reported. The patient had undergone multiple excisions and reconstructions of EMPD, however, had a benign cervical smear history and reported no vaginal bleeding. The conventional papanicolaou smear was reported as concerning for carcinoma with abundant, well preserved material illustrating highly atypical cells with anisonucleosis and dense cytoplasm and focal microacini...
July 7, 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/27379622/-grading-of-gynecological-tumors-current-aspects
#17
L-C Horn, D Mayr, C E Brambs, J Einenkel, I Sändig, K Schierle
Histopathological assessment of the tumor grade and cell type is central to the management and prognosis of various gynecological malignancies. Conventional grading systems for squamous carcinomas and adenocarcinomas of the vulva, vagina and cervix are poorly defined. For endometrioid tumors of the female genital tract as well as for mucinous endometrial, ovarian and seromucinous ovarian carcinomas, the 3‑tiered FIGO grading system is recommended. For uterine neuroendocrine tumors the grading system of the gastrointestinal counterparts has been adopted...
July 2016: Der Pathologe
https://www.readbyqxmd.com/read/27371362/vaginal-cytology-results-in-follow-up-of-endometrial-carcinoma-after-hysterectomy
#18
Chengquan Zhao, Arivarasan Karunamurthy, Sarika Jain, R Marshall Austin
OBJECTIVES: Our study examined accumulated data on vaginal cytology follow-up results of women treated for endometrial carcinoma (EmCa) by hysterectomy in a large academic women's hospital practice. METHODS: This study analyzed cases of EmCa treated by hysterectomy from January 2006 to December 2008 with documented follow-up vaginal cytology and/or vaginal biopsy results available prior to September 2013. RESULTS: Of 607 patients with EmCa who had documented hysterectomy findings, 420 had either follow-up vaginal biopsy or cytology results during a mean follow-up period of 42...
August 2016: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/27352582/vagina-as-a-rare-location-of-renal-cell-carcinoma-metastasis
#19
I L Ladjevic, A Stefanovic, S Kadija, M Terzic, K Jeremic, T Janjic
INTRODUCTION: Metastatic renal cell carcinoma is often found in distant organs, including lung, bone, brain, and liver. Metastases to the vagina are extremely rare. CASE REPORT: The authors present a case of renal cell carcinoma metastasis to the anterior vaginal wall four months after nephrectomy in a 56-year-old patient. The vaginal lesions were excised. After two years the patient had no signs of recurrence or the disease progression. CONCLUSION: Vaginal metastases should be considered in differential diagnosis of female renal cell carcinoma patients presenting with vaginal bleeding of mass...
2016: European Journal of Gynaecological Oncology
https://www.readbyqxmd.com/read/27347173/vaginal-implantation-metastasis-of-endometrial-carcinoma-a-case-report
#20
Yueling Wang, Jiang DU, Shulan Lv, Yanxia Sui, Xue Xue, Chao Sun, Junkai Zou, Qunying Ma, Guoxing Fu, Qing Song, Qiling Li
Endometrial cancer is the most common malignancy of the female reproductive system. The three common spread patterns of endometrial cancer are local invasion, lymphatic spread and hematogenous spread. Vaginal metastasis occurs by submucosal lymphatic or vascular metastases in ~10% of patients with clinical stage I disease. Vaginal implantation metastasis of endometrial cancer is extremely rare. Here we present a case of endometrial carcinoma (International Federation of Gynecology and Obstetrics stage IA) spread to the vagina by implantation metastasis as opposed to any of the methods mentioned above...
July 2016: Oncology Letters
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