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https://www.readbyqxmd.com/read/29471342/alternative-treatment-strategies-to-accelerate-the-elimination-of-onchocerciasis
#1
Michel Boussinesq, Grace Fobi, Annette C Kuesel
The use of alternative (or complementary) treatment strategies (ATSs) i.e. differing from annual community-directed treatment with ivermectin (CDTI) is required in some African foci to eliminate onchocerciasis by 2025. ATSs include vector control, biannual or pluriannual CDTI, better timing of CDTI, community-directed treatment with combinations of currently available anthelminthics or new drugs, and 'test-and-treat' (TNT) strategies requiring diagnosis of infection and/or contraindications to treatment for decisions on who to treat with what regimen...
March 1, 2018: International Health
https://www.readbyqxmd.com/read/29469962/apremilast-alters-behavioral-responses-to-ethanol-in-mice-i-reduced-ethanol-consumption-and-preference
#2
Yuri A Blednov, Adriana J Da Costa, Tamara Tarbox, Olga Ponomareva, Robert O Messing, R Adron Harris
BACKGROUND: Phosphodiesterase type 4 (PDE4) inhibitors produce widespread anti-inflammatory effects and reduce ethanol consumption in several rodent models. These drugs are potential treatments for several diseases, including central nervous system disorders, but clinical use is limited by their emetic activity. Apremilast is a selective PDE4 inhibitor with fewer gastrointestinal side effects that is FDA approved for the treatment of psoriasis. METHODS: We measured the acute and chronic effects of apremilast on ethanol consumption in male and female C57BL/6J mice using the continuous and intermittent 24-h two-bottle choice drinking models...
February 22, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29469943/effects-of-diagnostic-work-up-on-medical-decision-making-for-canine-urinary-tract-infection-an-observational-study-in-danish-small-animal-practices
#3
T M Sørensen, C R Bjørnvad, G Cordoba, P Damborg, L Guardabassi, V Siersma, L Bjerrum, L R Jessen
BACKGROUND: Clinical signs of urinary tract disease in dogs often lead to prescription of antibiotics. Appropriate diagnostic work-up could optimize treatment and reduce the risk of inappropriate use of antibiotics. HYPOTHESIS/OBJECTIVES: To describe and evaluate the impact of diagnostic work-up on decision to treat (DTT) and choice of antibiotic treatment (COT) for dogs presenting with clinical signs of urinary tract disease. ANIMALS: One hundred and fifty-one dogs presenting to 52 Danish veterinary practices...
February 22, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29469707/retronychia-an-underdiagnosed-disease
#4
A Robledo, E Godoy, E Manrique, P Manchado
Retronychia is a recently described cause of ingrowth of the nail plate on the ventral surface of the proximal nail fold. Clinical features are repeated episodes of proximal paronychia, nail plate thickening, and occasionally granulation tissue emergence. The usual treatments for paronychia such as antibiotics and antifungals are ineffective in these cases. Avulsion of the nail plate is the treatment of choice for these patients, but effective treatment is usually delayed owing to inadequate diagnosis. Herein, we describe a 28-year-old woman with a case of retronychia...
July 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29469699/mycophenolate-mofetil-as-a-successful-therapy-for-idiopathic-granulomatous-mastitis
#5
Fan Di Xia, Amy Ly, Gideon P Smith
Idiopathic granulomatous mastitis (IGM) is a benign chronic inflammatory breast disease of unknown etiology. No consensus exists as to the best therapeutic approach, though treatment choices include antibiotics, drainage, surgical excision, steroids, methotrexate, and observation. Herein we report a case of idiopathic granulomatous mastitis that was refractory to methotrexate and intralesional and systemic steroids but responded well to mycophenolate mofetil 1500mg twice daily. To our knowledge, this is the first report of the effective use of mycophenolate mofetil in idiopathic granulomatous mastitis...
July 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29469635/in-the-experimental-model-of-acute-mesenteric-ischemia-the-correlation-of-blood-diagnostic-parameters-with-the-duration-of-ischemia-and-their-effects-on-choice-of-treatment
#6
Mikail Cakir, Dogan Yildirim, Fatma Sarac, Turgut Donmez, Semih Mirapoglu, Adnan Hut, Fazilet Erozgen, Omer Faruk Ozer, Melih Ozgun Gecer, Leyla Zeynep Tigrel, Oguzhan Tas
Purpose/Aim: Acute mesenteric ischemia is a syndrome characterized by sudden onset abdominal pain followed by intestinal necrosis. Morbidity and mortality increase with delayed diagnosis. Even with the latest radiological diagnostic methods, early diagnosis and initiation of treatment can be delayed. Using an experimental model, here we aim to determine the relationship between the laboratory parameters used to detect acute mesenteric ischemia and the duration of irreversible ischemia. MATERIALS AND METHODS: A total of 30 male Wistar albino rats were divided into five groups, all of which underwent general anesthesia: (i) Superior mesenteric artery (SMA) dissection with laparotomy was performed, and blood samples and intestinal segment samples were taken after 2 hr (Sham group); (ii) volvulus of one-third of the small intestines was performed manually by laparotomy, and blood samples and intestinal segment samples were taken after 2 hr (Volvulus group); (iii) SMA was ligated with laparotomy, and blood samples and intestinal segment samples were taken after 2 hr (SMA+ligated 2-hr group); (iv) SMA was ligated with laparotomy, and blood samples and intestinal segment samples were taken after 4 hr (SMA+ligated 4-hr group); and (v) SMA was ligated with laparotomy, and blood samples and intestinal segment samples were taken after 6 hr (SMA+ligated 6-hr group)...
February 22, 2018: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/29469616/prehospital-echocardiography-during-resuscitation-impacts-treatment-in-a-physician-staffed-helicopter-emergency-medical-service-an-observational-study
#7
Rein Ketelaars, Christian Beekers, Geert-Jan Van Geffen, Gert Jan Scheffer, Nico Hoogerwerf
BACKGROUND: Patients in cardiac arrest must receive algorithm-based management such as basic life support and advanced (cardiac) life support. International guidelines dictate diagnosing and treating any factor that may have caused the arrest or may be complicating the resuscitation. Ultrasound may be of potential value in this process and can be used in a prehospital setting. The objective is to evaluate the use of prehospital ultrasound during traumatic and non-traumatic CPR and determine its impact on prehospital treatment decisions in a Dutch helicopter emergency medical service (HEMS)...
February 22, 2018: Prehospital Emergency Care
https://www.readbyqxmd.com/read/29469176/current-physiotherapy-practice-in-the-management-of-tennis-elbow-a-service-evaluation
#8
M Bateman, E Whitby, S Kacha, E Salt
BACKGROUND: Tennis elbow is a common painful condition that may affect daily function and ability to work. Physiotherapy is the most commonly used primary intervention but there is a wide range of treatment options within the umbrella of physiotherapy. Our aim was to report on the treatments that are currently used by physiotherapists in a UK National Health Service (NHS) setting. METHODS: A retrospective service evaluation was conducted at two NHS hospital trusts by reviewing patient attendance records over a 1-year period...
February 22, 2018: Musculoskeletal Care
https://www.readbyqxmd.com/read/29468604/urinary-diversion-after-radical-cystectomy-for-bladder-cancer-comparing-trends-in-the-us-and-germany-from-2006-to-2014
#9
Christer Groeben, Rainer Koch, Martin Baunacke, Marianne Schmid, Angelika Borkowetz, Manfred P Wirth, Johannes Huber
OBJECTIVE: Our aim was to assess and compare trends of urinary diversion (UD) for patients receiving radical cystectomy for the treatment of bladder cancer in the US and Germany, and to investigate decisive predictors for the choice of UD. METHODS: We analyzed the nationwide German hospital billing database and the Nationwide Inpatient Sample (NIS) from 2006 to 2014. Cases with a bladder cancer diagnosis combined with RC were included, and trends in the choice of UD, transfusion rates, length of stay, and mortality were assessed...
February 21, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29468435/additional-lymph-node-dissection-for-primary-colorectal-cancer-invading-another-colon-region
#10
Ryuma Tokunaga, Yasuo Sakamoto, Shigeki Nakagawa, Yuji Miyamoto, Naoya Yoshida, Hideo Baba
PURPOSE: Surgery remains the curative treatment of choice for colorectal cancer (CRC). However, to our knowledge, no report has addressed the usefulness of additional regional lymph node dissection for primary CRC that has invaded another colon region. METHODS: We reviewed the clinicopathological characteristics and outcomes of eight patients who underwent surgery between March, 2005 and August, 2014, for CRC that invaded another region of the colon. RESULTS: Five patients underwent additional regional lymph node dissection in the area of the invaded colon and one patient had lymph node metastasis in the region...
February 21, 2018: Surgery Today
https://www.readbyqxmd.com/read/29468363/the-bcr-abl-inhibitor-nilotinib-influences-phenotype-and-function-of-monocyte-derived-human-dendritic-cells
#11
Daniela Dörfel, Christian J Lechner, Simone Joas, Tanja Funk, Michael Gutknecht, Julia Salih, Julian Geiger, Korbinian N Kropp, Stefanie Maurer, Martin R Müller, Hans-Georg Kopp, Helmut R Salih, Frank Grünebach, Susanne M Rittig
In chronic myeloid leukemia (CML), the translocation t(9;22) results in the fusion protein BCR-ABL (breakpoint cluster region-abelson murine leukemia), a tyrosine kinase mediating oncogenic signaling which is successfully targeted by treatment with BCR-ABL inhibitors like imatinib. However, BCR-ABL inhibitors may also affect antitumor immunity. For instance, it was reported that imatinib impairs the function of dendritic cells (DCs) that play a central role in initiating and sustaining T cell responses. Meanwhile, second generation BCR-ABL inhibitors like nilotinib, which inhibits BCR-ABL with enhanced potency have become standard of treatment, at least in patients with BCR-ABL kinase domain mutations...
February 21, 2018: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/29468001/cerebral-venous-sinus-thrombosis-in-a-patient-with-meningococcal-meningitis
#12
Sudhir Kumar Palat Chirakkara, Abdul Rahim Ali Bakhsh, Aparna Kalyani Pariyadath, Balamurugan Rathinavelu
Meningococcal meningitis has a wide range of neurological complications. However, cerebral venous sinus thrombosis (CVST) following infection with Neisseria meningitidis is uncommon. We report a case of CVST in a 42-year-old male admitted with meningococcal meningitis. The patient was managed with antibiotics. Due to altered coagulation parameters observed in fulminant cases of meningococcemia, deployment of anticoagulation therapy, which would otherwise be the treatment of choice for CVST, is a dilemma.
January 2018: Oman Medical Journal
https://www.readbyqxmd.com/read/29467885/paclitaxel-plus-nedaplatin-vs-paclitaxel-plus-carboplatin-in-women-with-epithelial-ovarian-cancer-a-multi-center-randomized-open-label-phase-iii-trial
#13
Li Li, Qingqing Zhuang, Zeyi Cao, Rutie Yin, Yaping Zhu, Lirong Zhu, Xing Xie, Youzhong Zhang, Li Li, Qiang Wu, Jianhua Zheng, Qi Zhou, Xiaoping Li, Lingying Wu, Youji Feng, Changyu Wang
The multi-center, randomized, open-label, phase III trial discussed in the present study was performed to compare the clinical outcomes of nedaplatin (NDP) plus paclitaxel, and carboplatin (CBP) plus paclitaxel for the treatment of epithelial ovarian cancer (EOC). In the current study, 182 patients with International Federation of Gynecology and Obstetrics (FIGO) stage II-IV EOC were randomly assigned to receive NDP plus paclitaxel or CBP plus paclitaxel at 3-week intervals for a total of six courses. The primary endpoints were progression-free survival rate (PFS) and overall survival rate (OS)...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29467792/evaluation-of-bioinformatics-approaches-for-next-generation-sequencing-analysis-of-micrornas-with-a-toxicogenomics-study-design
#14
Halil Bisgin, Binsheng Gong, Yuping Wang, Weida Tong
MicroRNAs (miRNAs) are key post-transcriptional regulators that affect protein translation by targeting mRNAs. Their role in disease etiology and toxicity are well recognized. Given the rapid advancement of next-generation sequencing techniques, miRNA profiling has been increasingly conducted with RNA-seq, namely miRNA-seq. Analysis of miRNA-seq data requires several steps: (1) mapping the reads to miRBase, (2) considering mismatches during the hairpin alignment (windowing), and (3) counting the reads (quantification)...
2018: Frontiers in Genetics
https://www.readbyqxmd.com/read/29466936/utilization-and-in-hospital-outcomes-associated-with-atherectomy-in-the-treatment-of-peripheral-vascular-disease-an-observational-analysis-from-the-national-inpatient-sample
#15
Rajkumar Doshi, Evan Shlofmitz, Perwaiz Meraj
Objective Percutaneous revascularization for patients with peripheral arterial disease has become a treatment of choice for many symptomatic patients. The presence of severe arterial calcification presents many challenges for successful revascularization. Atherectomy is an adjunctive treatment option for patients with severe calcification undergoing percutaneous intervention. We sought to analyze the impact of atherectomy on in-hospital outcomes, length of stay, and cost in the percutaneous treatment of peripheral arterial disease...
January 1, 2018: Vascular
https://www.readbyqxmd.com/read/29466825/responses-to-warnings-about-the-impact-of-eating-disorders-on-fertility-a-qualitative-study
#16
Su Holmes
Eating disorders (EDs) have often been discussed as a risk to reproductive health. But existing research is quantitative in nature, paying no attention to issues of patient experience. In discussing data from 24 semi-structured interviews, this article draws on sociological approaches to medical 'risk' and feminist approaches to EDs to explore how women with experience of an ED responded to fertility warnings within treatment contexts. In doing so, it is suggested that responses to fertility warnings offer unique insight into the potentially damaging limitations of biomedical approaches to eating problems and their focus on EDs as individual 'pathologies' (rather than culturally embedded expressions of gendered embodiment)...
February 21, 2018: Sociology of Health & Illness
https://www.readbyqxmd.com/read/29466291/recommendations-and-choices-for-brca-mutation-carriers-at-risk-for-ovarian-cancer-a-complicated-decision
#17
REVIEW
Kelsey E Lewis, Karen H Lu, Amber M Klimczak, Samuel C Mok
Current ovarian cancer screening guidelines in high-risk women vary according to different organizations. Risk reducing surgery remains the gold standard for definitive treatment in BRCA mutation carriers, but research advancements have created more short-term options for patients to consider. The decisions involved in how a woman manages her BRCA mutation status can cause a great deal of stress and worry due to the imperfect therapy options. The goal of this review was to critically analyze the screening recommendations and alternative options for high-risk ovarian cancer patients and evaluate how these discrepancies and choices affect a woman's management decisions...
February 21, 2018: Cancers
https://www.readbyqxmd.com/read/29466227/-lizinopril-in-the-treatment-of-arterial-hypertension
#18
V I Podzolkov, A I Tarsimanova
Despite availability of a wide selection of antihypertensive drugs, only a small portion of patients with arterial hypertension are treated effectively. Angiotensin converting enzyme inhibitors (ACEI) are considered drugs of first choice for starting therapy of uncomplicated arterial hypertension. Among large number of representatives of this class lisinopril deserves special attention as one of best known and well-studied ACEIs. Wide spectrum of activity and proven organoprotective qualities of lisinopril allow to use it a variety of situations...
September 2017: Kardiologiia
https://www.readbyqxmd.com/read/29466083/laparoscopic-nissen-fundoplication-an-excellent-treatment-of-gerd-related-respiratory-symptoms-in-children-results-of-a-multicentric-study
#19
Ciro Esposito, Amulya Saxena, Sabine Irtan, Holger Till, Maria Escolino
INTRODUCTION: Respiratory manifestations of gastroesophageal reflux disease (GERD), particularly chronic cough, are being recognized with increased frequency in children. This survey aimed to investigate the efficacy of laparoscopic Nissen fundoplication for treatment of GERD-related respiratory symptoms not responsive to medical therapy in neurological normal children. MATERIALS AND METHODS: We collected data of children with GERD-related respiratory complaints not responsive to medical therapy who underwent laparoscopic Nissen fundoplication in four European centers of Pediatric Surgery over a 10-year period...
February 21, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29465899/electroclinical-and-prognostic-characteristics-of-epilepsy-patients-with-photosensitivity
#20
Hülya Olgun Yazar, Günay Gül, Tamer Yazar, Fulya Eren, Demet-Yandım Kuscu, Dursun Kirbas
Background and purpose: Epilepsy with photosensitivity (PSE) is one of the reflex epilepsy types with pathophysiology still unexplained. In our study we aimed to evaluate the clinical, electroencephalogram (EEG) and prognosis of patients with PSE diagnosis. Methods: A total of 44 patients with PSE diagnosis according to international classification were included in this retrospective and cross-sectional study. The age, gender, syndrome, clinical and EEG characteristics of patients, and treatment response were investigated...
January 30, 2018: Ideggyógyászati Szemle
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