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https://www.readbyqxmd.com/read/28937590/logistic-model-to-support-service-modularity-for-the-promotion-of-reusability-in-a-web-objects-enabled-iot-environment
#1
Muhammad Golam Kibria, Sajjad Ali, Muhammad Aslam Jarwar, Sunil Kumar, Ilyoung Chong
Due to a very large number of connected virtual objects in the surrounding environment, intelligent service features in the Internet of Things requires the reuse of existing virtual objects and composite virtual objects. If a new virtual object is created for each new service request, then the number of virtual object would increase exponentially. The Web of Objects applies the principle of service modularity in terms of virtual objects and composite virtual objects. Service modularity is a key concept in the Web Objects-Enabled Internet of Things (IoT) environment which allows for the reuse of existing virtual objects and composite virtual objects in heterogeneous ontologies...
September 22, 2017: Sensors
https://www.readbyqxmd.com/read/28925073/role-of-cardiopulmonary-exercise-testing-in-clinical-stratification-in-heart-failure-a-position-paper-from-the-committee-on-exercise-physiology-and-training-of-the-heart-failure-association-of-the-european-society-of-cardiology
#2
REVIEW
Ugo Corrà, Pier Giuseppe Agostoni, Stefan D Anker, Andrew J S Coats, Maria G Crespo Leiro, Rudolph A de Boer, Veli-Pekka Hairola, Loreena Hill, Mitja Lainscak, Lars H Lund, Marco Metra, Piotr Ponikowski, Jillian Riley, Petar M Seferović, Massimo F Piepoli
Traditionally, the main indication for cardiopulmonary exercise testing (CPET) in heart failure (HF) was for the selection of candidates to heart transplantation: CPET was mainly performed in middle-aged male patients with HF and reduced left ventricular ejection fraction. Today, CPET is used in broader patients' populations, including women, elderly, patients with co-morbidities, those with preserved ejection fraction, or left ventricular assistance device recipients, i.e. individuals with different responses to incremental exercise and markedly different prognosis...
September 18, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28919397/inferring-within-host-bottleneck-size-a-bayesian-approach
#3
R Dybowski, O Restif, D J Price, P Mastroeni
Recent technical developments in microbiology have led to new discoveries on the within-host dynamics of bacterial infections in laboratory animals. In particular, they have highlighted the importance of stochastic bottlenecks at the onset of invasive disease. A number of approaches exist for bottleneck-size estimation with respect to within-host bacterial infections; however, some are more appropriate than others under certain circumstances. A Bayesian comparison of several approaches is made in terms of the availability of isogenic multitype bacteria (e...
September 14, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28918630/assessing-the-reliability-of-mfa-results-the-cases-of-rhenium-gallium-and-germanium-in-the-us-economy
#4
Grégoire Meylan, Barbara K Reck, Helmut Rechberger, Thomas E Graedel, Oliver Schwab
Decision-makers traditionally expect "hard facts" from scientific inquiry, an expectation the results of Material Flow Analyses (MFAs) can hardly meet. MFA limitations are attributable to incompleteness of flowcharts, limited data quality, and model assumptions. Moreover, MFA results are mostly less based on empirical observation and rather on social knowledge construction processes. Developing, applying, and improving means for evaluating and communicating reliability of MFA results is imperative. We apply two recently proposed approaches for making quantitative statements on MFA reliability to national minor metals systems: rhenium, gallium, and germanium in the US in 2012...
September 18, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28878778/multivariate-analysis-as-a-support-for-diagnostic-flowcharts-in-allergic-bronchopulmonary-aspergillosis-a-proof-of-concept-study
#5
Joana Vitte, Stéphane Ranque, Ania Carsin, Carine Gomez, Thomas Romain, Carole Cassagne, Marion Gouitaa, Mélisande Baravalle-Einaudi, Nathalie Stremler-Le Bel, Martine Reynaud-Gaubert, Jean-Christophe Dubus, Jean-Louis Mège, Jean Gaudart
Molecular-based allergy diagnosis yields multiple biomarker datasets. The classical diagnostic score for allergic bronchopulmonary aspergillosis (ABPA), a severe disease usually occurring in asthmatic patients and people with cystic fibrosis, comprises succinct immunological criteria formulated in 1977: total IgE, anti-Aspergillus fumigatus (Af) IgE, anti-Af "precipitins," and anti-Af IgG. Progress achieved over the last four decades led to multiple IgE and IgG(4) Af biomarkers available with quantitative, standardized, molecular-level reports...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28873881/developing-an-assessment-tool-for-touch-screen-devices
#6
Alexandra Danial-Saad, Lorenzo Chiari
Touch screen devices have become prevalent in our lives. Assistive technology experts working with people with disabilities face difficulty in understanding and assessing the problems experienced by individuals with disabilities in operating touch screen devices. This paper presents the processes of collecting and creating the required knowledge needed for assessing the user's skills for operating various touch screen devices, in order to develop an application for assessing the user's abilities and limitations...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28846594/low-fodmap-diet-improves-irritable-bowel-syndrome-symptoms-a-meta-analysis
#7
REVIEW
Emma Altobelli, Valerio Del Negro, Paolo Matteo Angeletti, Giovanni Latella
Irritable bowel syndrome (IBS) affects 7-15% of the general population. A recently devised dietary approach consists of restricting foods with highly fermentable oligo-, di-, and monosaccharides, and polyols (FODMAPs), which can trigger and/or exacerbate IBS symptoms. The aim of this study is to use meta-analysis to provide an update on the randomised control trials (RCTs) and cohort studies, and examine them separately in relation to diet type. Papers were selected using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flowchart...
August 26, 2017: Nutrients
https://www.readbyqxmd.com/read/28838352/syndromic-management-of-sexually-transmissible-infections-in-resource-poor-settings-a-systematic-review-with-meta-analysis-of-the-abnormal-vaginal-discharge-flowchart-for-neisseria-gonorrhoea-and-chlamydia-trachomatis
#8
Caroline van Gemert, Margaret Hellard, Catriona S Bradshaw, Freya J I Fowkes, Paul A Agius, Mark Stoove, Catherine M Bennett
Background: Syndromic management of sexually transmissible infections is commonly used in resource-poor settings for the management of common STIs; abnormal vaginal discharge (AVD) flowcharts are used to identify and treat cervical infection including Neisseria gonorrhoea and Chlamydia trachomatis. A systematic review and meta-analysis was undertaken to measure the diagnostic test performance of AVD flowcharts, including both World Health Organization (WHO)- and locally-adapted AVD flowcharts. Methods: A systematic search of multiple electronic databases was conducted to locate eligible studies published between 1991 and 2014...
August 25, 2017: Sexual Health
https://www.readbyqxmd.com/read/28801845/accurate-analytical-method-for-human-plasma-glucagon-levels-using-liquid-chromatography-high-resolution-mass-spectrometry-comparison-with-commercially-available-immunoassays
#9
Atsushi Miyachi, Masaki Kobayashi, Eri Mieno, Moritaka Goto, Kenichi Furusawa, Takashi Inagaki, Tadahiro Kitamura
Accurate quantification of plasma glucagon levels in humans is necessary for understanding the physiological and pathological importance of glucagon. Although several immunoassays for glucagon are available, they provide inconsistent glucagon values owing to cross-reactivity of the antibodies with peptides other than glucagon. To overcome this limitation, we developed a novel method to measure glucagon levels by a liquid chromatography (LC)-high-resolution mass spectrometry (HRMS) assay via parallel reaction monitoring (PRM) without immunoaffinity enrichment...
August 12, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28801691/a-new-data-processing-routine-facilitating-the-identification-of-surface-adhered-proteins-from-bacterial-conditioning-films-via-qcm-d-maldi-tof-ms
#10
Siegfried Hohmann, Anke Neidig, Boris Kühl, Frank Kirschhöfer, Jörg Overhage, Gerald Brenner-Weiß
Conditioning films are an important factor in the initiation and development of microbial biofilms, which are the leading cause of chronic infections associated with medical devices. Here, we analyzed the protein content of conditioning films formed after exposure to supernatants of cultures of the human pathogen Pseudomonas aeruginosa PAO1. Adhesion of substances from the supernatant was monitored using quartz crystal microbalance with dissipation monitoring (QCM-D) sensor chips modified with the commonly used implant material titanium dioxide (TiO2)...
August 11, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28767028/-the-dutch-college-of-general-practitioners-practice-guideline-suspicious-skin-lesions
#11
Z Damen-van Beek, W Opstelten
- The Dutch College of General Practitioners practice guideline 'Suspicious skin lesions' provides recommendations for diagnosis, treatment and referral for the most common premalignant and malignant skin disorders.- The practice guideline includes a flowchart which starts by looking at the colour and surface of the skin lesion to direct the general practitioner to the most likely diagnosis.- In case of strong suspicion of squamous cell carcinoma, keratoacanthoma or melanoma and in case of basal cell carcinoma or Bowen's disease with high-risk characteristics, the general practitioner will refer the patient to a dermatologist...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28737421/matrix-effect-management-in-liquid-chromatography-mass-spectrometry-the-internal-standard-normalized-matrix-effect
#12
Amedeo De Nicolò, Marco Cantù, Antonio D'Avolio
LC-MS is becoming a standard for many applications, thanks to high sensitivity and selectivity; nevertheless, some issues are still present, particularly due to matrix effect (ME). Considering this, the use of optimal internal standards (ISs, usually stable-isotope labeled) is important, but not always possible because of cost or availability. Therefore, a deep investigation of the inter-lot variability of the ME and of the correcting power of the chosen IS (isotope-labeled or not) is mandatory. While the adoption of isotopically labeled ISs considered as a 'gold standard' to mitigate ME impact on analytical results, there is not consensus about the standard technique to evaluate it during method validation...
July 24, 2017: Bioanalysis
https://www.readbyqxmd.com/read/28734287/on-the-thermophysical-and-transport-properties-of-3-he-and-4-he-a-bubble-interaction-potential-versus-state-of-the-art
#13
Michael Chrysos, Henri Piel
Three keynote thermophysical and transport properties of (3)He and (4)He, namely, the second virial coefficient, the shear viscosity, and the thermal conductivity, are reported for the "extended Dirac bubble potential" (EDbp), a novel model for He-He [M. Chrysos, J. Chem. Phys. 146, 024106 (2017)]. Comparisons with the experiment as well as with potentials with a proven track record and with the oversimplified Dbp are being made in the range 0.1-500 K to analyze the performance of the EDbp, which is shown here to emerge as a promising analytic model for He-He...
July 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28716204/a-protocol-to-identify-and-minimise-selection-and-information-bias-in-abattoir-surveys-estimating-prevalence-using-fasciola-hepatica-as-an-example
#14
Rebecca I Carroll, Andrew Forbes, David A Graham, Locksley L McV Messam
Abattoir surveys and findings from post-mortem meat inspection are commonly used to estimate infection or disease prevalence in farm animal populations. However, the function of an abattoir is to slaughter animals for human consumption, and the collection of information on animal health for research purposes is a secondary objective. This can result in methodological shortcomings leading to biased prevalence estimates. Selection bias can occur when the study population as obtained from the abattoir is not an accurate representation of the target population...
September 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28704749/key-role-of-the-sorption-process-in-alteration-of-metal-and-metalloid-quantification-by-fouling-development-on-dgt-passive-samplers
#15
Delphine Devillers, Rémy Buzier, Malgorzata Grybos, Adeline Charriau, Gilles Guibaud
The DGT technique (diffusive gradients in thin films) is widely used for passive sampling of labile trace metals and metalloids in natural waters. Although development of fouling on the protective membranes is frequently observed, its effect on DGT sampling has been barely investigated. This study evaluates the influence of fouling on sampling of trace cationic metals Cd(II), Cu(II), Ni(II) and Pb(II) and oxyanions As(V), Cr(VI), Sb(V) and Se(VI). Fouling was developed in situ on polycarbonate membranes in four diverse natural freshwater environments and sampling alteration was assessed in controlled laboratory experiments...
November 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28699732/fundamental-and-practical-insights-on-the-packing-of-modern-high-efficiency-analytical-and-capillary-columns
#16
M Farooq Wahab, Darshan C Patel, Rasangi M Wimalasinghe, Daniel W Armstrong
New stationary phases are continuously developed for achieving higher efficiencies and unique selectivities. The performance of any new phase can only be assessed when the columns are effectively packed under high pressure to achieve a stable bed. The science of packing columns with stationary phases is one of the most crucial steps to achieve consistent and reproducible high-resolution separations. A poorly packed column can produce non-Gaussian peak shapes and lower detection sensitivities. Given the ever larger number of stationary phases, it is impossible to arrive at a single successful approach...
July 12, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28685969/the-cytochrome-p450-3a4-has-three-major-conformations-new-clues-to-drug-recognition-by-this-promiscuous-enzyme
#17
Lydia Benkaidali, François André, Gautier Moroy, Bahoueddine Tangour, François Maurel, Michel Petitjean
We computed the channels of the 3A4 isoform of the cytochrome P450 3A4 (CYP) on the basis of 24 crystal structures extracted from the Protein Data Bank (PDB). We identified three major conformations (denoted C, O1 and O2) using an enhanced version of the CCCPP software that we developed for the present work, while only two conformations (C and O(2) ) are considered in the literature. We established the flowchart of definition of these three conformations in function of the structural and physicochemical parameters of the ligand...
July 7, 2017: Molecular Informatics
https://www.readbyqxmd.com/read/28670801/australian-and-new-zealand-committee-on-resuscitation-neonatal-resuscitation-guidelines-2016
#18
Helen G Liley, Lindsay Mildenhall, Peter Morley
New Australian and New Zealand Neonatal Resuscitation guidelines reflect recent advances in neonatal resuscitation science, as critically appraised by the International Liaison Committee on Resuscitation. Substantial changes since the 2010 guidelines include: (i) updates to the Newborn Resuscitation Flowchart to include a greater emphasis on maintaining normal body temperature, and to emphasise the importance of beginning assisted ventilation by 1 min in infants who have absent or ineffective spontaneous breathing; (ii) updates to the physiology of the normal perinatal transition that resuscitation is trying to restore; (iii) recommendations for more frequent reinforcement of training, and for structured feedback for resuscitation training instructors; (iv) new guidance in relation to the timing of cord clamping for preterm newborn infants; (v) recommendation to monitor body temperature on admission to newborn units as a resuscitation quality indicator; (vi) suggestion to consider electrocardiographic (ECG) monitoring (as an adjunct to oximetry) to obtain more rapid and accurate estimation of heart rate during resuscitation; (vii) removal of previous suggestions to intubate meconium-exposed, non-vigorous term infants to suction the trachea; and (viii) suggestion to establish vascular access to enable administration of intravenous adrenaline (epinephrine) as soon as chest compressions are deemed to be needed...
July 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/28651987/management-of-the-incidental-renal-mass%C3%A2-on-ct-a-white-paper-of-the-acr%C3%A2-incidental-findings-committee
#19
Brian R Herts, Stuart G Silverman, Nicole M Hindman, Robert G Uzzo, Robert P Hartman, Gary M Israel, Deborah A Baumgarten, Lincoln L Berland, Pari V Pandharipande
The ACR Incidental Findings Committee (IFC) presents recommendations for renal masses that are incidentally detected on CT. These recommendations represent an update from the renal component of the JACR 2010 white paper on managing incidental findings in the adrenal glands, kidneys, liver, and pancreas. The Renal Subcommittee, consisting of six abdominal radiologists and one urologist, developed this algorithm. The recommendations draw from published evidence and expert opinion and were finalized by informal iterative consensus...
June 22, 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/28641736/a-comprehensive-rehabilitation-program-for-posterior-instability-of-the-shoulder
#20
Lyn Watson, Simon Balster, Sarah Ann Warby, Jackie Sadi, Greg Hoy, Tania Pizzari
Posterior shoulder instability is recognised as being less prevalent than anterior instability, however the diagnosis of this pathology is easily overlooked or missed and this may contribute to an underestimation of prevalence. Recently, there has been increasing recognition of this condition and consequently a greater requirement for knowledge of diagnostic procedures and treatment directions. Currently there is limited research into the conservative management of posterior instability, although it is recommended as first-line treatment prior to surgical review, particularly in those with an atraumatic instability mechanism...
April 2017: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
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