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https://www.readbyqxmd.com/read/27856551/scientific-process-flowchart-assessment-spfa-a-method-for-evaluating-changes-in-understanding-and-visualization-of-the-scientific-process-in-a-multidisciplinary-student-population
#1
Kristy J Wilson, Bessie Rigakos
The scientific process is nonlinear, unpredictable, and ongoing. Assessing the nature of science is difficult with methods that rely on Likert-scale or multiple-choice questions. This study evaluated conceptions about the scientific process using student-created visual representations that we term "flowcharts." The methodology, Scientific Process Flowchart Assessment (SPFA), consisted of a prompt and rubric that was designed to assess students' understanding of the scientific process. Forty flowcharts representing a multidisciplinary group without intervention and 26 flowcharts representing pre- and postinstruction were evaluated over five dimensions: connections, experimental design, reasons for doing science, nature of science, and interconnectivity...
2016: CBE Life Sciences Education
https://www.readbyqxmd.com/read/27842971/application-of-ich-q9-quality-risk-management-tools-for-advanced-development-of-hot-melt-coated-multiparticulate-systems
#2
Elena Stocker, Karin Becker, Siddhi Hate, Roland Hohl, Wolfgang Schiemenz, Stephan Sacher, Andreas Zimmer, Sharareh Salar-Behzadi
This study aimed to apply quality risk management based on the The International Conference on Harmonisation guideline Q9 for the early development stage of hot melt coated multiparticulate systems for oral administration. N-acetylcysteine crystals were coated with a formulation composing tripalmitin and polysorbate 65. The critical quality attributes (CQAs) were initially prioritized using failure mode and effects analysis. The CQAs of the coated material were defined as particle size, taste-masking efficiency, and immediate release profile...
November 11, 2016: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27752465/pulmonary-tuberculosis-followed-by-sarcoidosis-in-an-hiv-infected-patient-a-case-report-and-a-simplified-diagnostic-flowchart-for-diagnosis-and-treatment-of-sarcoidosis
#3
P Mencarini, R Bellagamba, A Oliva, P Ghirga, M L Giancola, A Corpolongo, T Ascoli Bartoli, P De Nardo, A Baiocchini, F Del Nonno, P Narciso, E Nicastri
The diagnosis of sarcoidosis in a patient living with HIV infection is an uncommon event and a challenge for clinicians. Clinical manifestations are variable and fluctuating depending to adherence to ARV therapy and to the level of CD4 count. We analyze here one chronic case in which sarcoidosis appeared clinically two years after pulmonary tuberculosis. The course of the disease was influenced and prolonged by frequent interruptions of antiretroviral therapy. Moreover the diagnosis and the decision to treat have been delayed by the need of exclusion of other pathologies, principally tuberculosis reactivation/reinfection, other mycobacterial diseases, hematologic malignancies...
2016: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/27752311/reducing-the-occurrence-of-errors-in-a-laboratory-s-specimen-receiving-and-processing-department
#4
Nouf Al Saleem, Khaled Al-Surimi
Frequent, preventable medical errors can have an adverse effect on patient safety and quality as well as leading to wasted resources. In the laboratory, errors can occur at any stage of sample processing; pre-analytical, analytical, and post analytical stages. However evidence shows most of the laboratory errors occur during the pre-analytical stage. The receipt and processing of specimens is one of the main steps in the pre-analytical stage. Errors in this stage could be due to mislabeling, incorrect test entry and entering the wrong location, among other reasons...
2016: BMJ Quality Improvement Reports
https://www.readbyqxmd.com/read/27749266/a-review-of-aluminium-phosphide-poisoning-and-a-flowchart-to-treat-it
#5
Behrooz Hashemi-Domeneh, Nasim Zamani, Hossein Hassanian-Moghaddam, Mitra Rahimi, Shahin Shadnia, Peyman Erfantalab, Ali Ostadi
The use of pesticides such as aluminium phosphide (AlP) has increased in the recent years and improved the quantity and quality of agricultural products in a number of developing countries. The downside is that AlP causes severe chronic and acute health effects that have reached major proportions in countries such as India, Iran, Bangladesh, and Jordan. Nearly 300,000 people die due to pesticide poisoning in the world every year. Poisoning with AlP accounts for many of these deaths. Unfortunately, at the same time, there is no standard treatment for it...
September 1, 2016: Arhiv za Higijenu Rada i Toksikologiju
https://www.readbyqxmd.com/read/27737378/home-delivery-medicament-program-access-inactivity-and-cardiovascular-risk
#6
Roque da Silva Araújo, Edna Apparecida Moura Arcuri, Victor Cauê Lopes
Objective: to verify causes of inactivity in the Home Delivery Medicament Program, as referred by users from a Primary Health Care Service in São Paulo, comparing them to the causes registered in the program and analyzing them in the theoretical model Concept of Access to Health. Methods: cross-sectional study, interviewing 111 inactive users; and documentary study in the program records. Results: half of the users did not know the condition of inactivity...
October 10, 2016: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/27729704/esmolol-corrects-severe-hypoxemia-in-patients-with-femoro-femoral-venoarterial-extracorporeal-life-support-for-lung-transplantation
#7
Mohamed Ghalayini, Pierre-Yves Brun, Pascal Augustin, Elise Guivarch, Marie Pierre Dilly, Sophie Provenchere, Pierre Mordant, Yves Castier, Philippe Montravers, Dan Longrois
Competitive flows syndrome result in severe regional hypoxemia when the deoxygenated flow from the native left ventricle (LV) competes with oxygenated flow from extracorporeal life support (ECLS) pump with potentially severe consequences for the cerebral and coronary circulations. Fast correction of hypoxemia could be obtained by decreasing native LV flow by infusion of a short-acting beta-blocker (esmolol). Our purpose was to retrospectively review the efficacy of esmolol in this situation and hypothesize on the potential mechanisms of action and the associated risks...
September 2016: Journal of Extra-corporeal Technology
https://www.readbyqxmd.com/read/27706174/the-performance-of-the-vaginal-discharge-syndromic-management-in-treating-vaginal-and-cervical-infection-a-systematic-review-and-meta-analysis
#8
Charifa Zemouri, Teodora Elvira Wi, James Kiarie, Armando Seuc, Vittal Mogasale, Ahmed Latif, Nathalie Broutet
BACKGROUND: This review aimed to synthesize and analyze the diagnostic accuracy and the likelihood of providing correct treatment of the syndromic approach Vaginal Discharge Flowchart in managing cervical infections caused by Neisseria gonorrhoeae (NG) and Chlamydia trachomatis (CT), and vaginal infections caused by Trichomonas vaginalis (TV) and Bacterial vaginosis (BV) and Candida albicans. This review will inform updating the WHO 2003 guidelines on Vaginal Discharge syndromic case management...
2016: PloS One
https://www.readbyqxmd.com/read/27695202/promise-and-ontological-ambiguity-in-the-in-vitro-meat-imagescape-from-laboratory-myotubes-to-the-cultured-burger
#9
Neil Stephens, Martin Ruivenkamp
In vitro meat (IVM), also known as cultured meat, involves growing cells into muscle tissue to be eaten as food. The technology had its most high-profile moment in 2013 when a cultured burger was cooked and tasted in a press conference. Images of the burger featured in the international media and were circulated across the Internet. These images-literally marks on a two-dimensional surface-do important work in establishing what IVM is and what it can do. A combination of visual semiotics and narrative analysis shows that images of IVM afford readings of their story that are co-created by the viewer...
July 2, 2016: Science As Culture
https://www.readbyqxmd.com/read/27687465/chlorhexidine-related-refractory-anaphylactic-shock-a-case-successfully-resuscitated-with-extracorporeal-membrane-oxygenation
#10
Man-Ling Wang, Ching-Tao Chang, Hsing-Hao Huang, Yu-Chang Yeh, Tzong-Shiun Lee, Kuan-Yu Hung
IMPORTANCE: We report a patient with a life-threatening anaphylactic reaction to a chlorhexidine-coated central venous catheter, confirmed with a high serum level of chlorhexidine-specific IgE. To our knowledge, this is the first case successfully resuscitated using extracorporeal membrane oxygenation (ECMO). Great caution is required when using chlorhexidine and chlorhexidine-impregnated catheters, given that its widespread use has the potential to sensitize certain patients and may result in life-threatening anaphylaxis on subsequent exposure...
November 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27677259/reporting-studies-on-time-to-diagnosis-proposal-of-a-guideline-by-an-international-panel-rest
#11
Elise Launay, Jérémie F Cohen, Patrick M Bossuyt, Pierre Buekens, Jonathan Deeks, Timothy Dye, Richard Feltbower, Andrea Ferrari, Michael Kramer, Mariska Leeflang, David Moher, Karel G Moons, Erik von Elm, Philippe Ravaud, Martin Chalumeau
BACKGROUND: Studies on time to diagnosis are an increasing field of clinical research that may help to plan corrective actions and identify inequities in access to healthcare. Specific features of time to diagnosis studies, such as how participants were selected and how time to diagnosis was defined and measured, are poorly reported. The present study aims to derive a reporting guideline for studies on time to diagnosis. METHODS: Each item of a list previously used to evaluate the completeness of reporting of studies on time to diagnosis was independently evaluated by a core panel of international experts (n = 11) for relevance and readability before an open electronic discussion allowed consensus to be reached on a refined list...
September 27, 2016: BMC Medicine
https://www.readbyqxmd.com/read/27645285/recruitment-and-representativeness-of-blood-donors-in-the-interval-randomised-trial-assessing-varying-inter-donation-intervals
#12
Carmel Moore, Thomas Bolton, Matthew Walker, Stephen Kaptoge, David Allen, Michael Daynes, Susan Mehenny, Jennifer Sambrook, Nicholas A Watkins, Gail Miflin, Emanuele Di Angelantonio, Willem H Ouwehand, David J Roberts, John Danesh, Simon G Thompson
BACKGROUND: The interpretation of trial results can be helped by understanding how generalisable they are to the target population for which inferences are intended. INTERVAL, a large pragmatic randomised trial of blood donors in England, is assessing the effectiveness and safety of reducing inter-donation intervals. The trial recruited mainly from the blood service's static centres, which collect only about 10 % of whole-blood donations. Hence, the extent to which the trial's participants are representative of the general blood donor population is uncertain...
2016: Trials
https://www.readbyqxmd.com/read/27640207/workflow-for-multi-analyte-bioprocess-monitoring-demonstrated-on-inline-nir-spectroscopy-of-p-chrysogenum-fermentation
#13
Pekka Luoma, Aydin Golabgir, Markus Brandstetter, Jürgen Kasberger, Christoph Herwig
Fourier transform near-infrared (FT-NIR) spectroscopy combined with multivariate analysis has been applied in bioprocesses for a couple of decades. Nevertheless the papers published in this field are case-specific and do not focus on providing the community generic workflows to conduct experiments, especially as a standard Design of Experiment (DoE) for a multi-analyte process might require overwhelming amount of measurements. In this paper, a workflow for feasibility studies and inline implementation of FT-NIR spectrometer in multi-analyte fermentation processes is presented...
September 17, 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/27631773/a-proposed-road-map-for-the-ethical-evaluation-of-sham-placebo-surgery
#14
Vittoradolfo Tambone, Dario Sacchini, Antonio G Spagnolo, Rosa Menga, Giovanna Ricci, Roberto Valenti, Massimiliano Andrea Vitali, Massimo Ciccozzi
OBJECTIVE: The study proposes a possible roadmap for the ethical assessment of sham surgery clinical trials (CTs), focusing on methodological aspects, as a result of the lack of this type of practical tool in the literature/practice. BACKGROUND: Surgical procedures are frequently conducted without closely controlled studies. For this reason, these procedures are less rigorous than those for drug/device clinical trials. The aim of a sham (placebo) surgery CT is to carry out a surgical CT with a legitimate control group...
September 14, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27631657/management-of-cochlear-implant-electrode-migration
#15
Tobias Rader, Uwe Baumann, Timo Stöver, Tobias Weissgerber, Youssef Adel, Martin Leinung, Silke Helbig
OBJECTIVE: The present study reviewed a cochlear implant (CI) patient population after surgery, which received a free-fitting electrode carrier designed for hearing preservation. The aim was to determine the rate of electrode migration of the CI electrodes and present clinical and surgical implications. STUDY DESIGN: Retrospective patient review. SETTING: Tertiary referral university hospital. PATIENTS: Two hundred seventy-eight patients implanted uni- or bilaterally with lateral wall electrodes designed for hearing preservation (358 implants)...
October 2016: Otology & Neurotology
https://www.readbyqxmd.com/read/27594906/veno-occlusive-disease-nurse-management-development-of-a-dynamic-monitoring-tool-by-the-gitmo-nursing-group
#16
Stefano Botti, Laura Orlando, Gianpaolo Gargiulo, Valentina De Cecco, Marina Banfi, Lorenzo Duranti, Emanuela Samarani, Maria Giovanna Netti, Marco Deiana, Vera Galuppini, Adriana Concetta Pignatelli, Rosanna Ceresoli, Alessio Vedovetto, Elena Rostagno, Marilena Bambaci, Cristina Dellaversana, Stefano Luminari, Francesca Bonifazi
Veno-occlusive disease (VOD) is a complication arising from the toxicity of conditioning regimens that have a significant impact on the survival of patients who undergo stem cell transplantation. There are several known risk factors for developing VOD and their assessment before the start of conditioning regimens could improve the quality of care. Equally important are early identification of signs and symptoms ascribable to VOD, rapid diagnosis, and timely adjustment of support therapy and treatment. Nurses have a fundamental role at the stages of assessment and monitoring for signs and symptoms; therefore, they should have documented skills and training...
2016: Ecancermedicalscience
https://www.readbyqxmd.com/read/27587192/-healthcare-structures-in-palliative-care-medicine-flowchart-for-patients-with-incurable-cancer
#17
S T Simon, A Pralong, U Welling, R Voltz
BACKGROUND: In Germany the structures of generalized and specialized palliative care services have considerably increased over the last decade with respect to the number, quality and differentiation. The goal is to improve or to maintain the quality of life for patients with life-threatening illnesses. AIM: The current structures of generalized and specialized palliative care services in Germany are presented. MATERIAL AND METHODS: The structures of healthcare services are presented primarily based on the S3 guidelines on palliative care for patients with incurable cancer...
October 2016: Der Internist
https://www.readbyqxmd.com/read/27579934/manchester-triage-system-main-flowcharts-discriminators-and-outcomes-of-a-pediatric-emergency-care
#18
Camila Amthauer, Maria Luzia Chollopetz da Cunha
OBJETIVE: to characterize the care services performed through risk rating by the Manchester Triage System, identifying demographics (age, gender), main flowcharts, discriminators and outcomes in pediatric emergency. METHOD: cross-sectional quantitative study. Data on risk classification were obtained through a search of computerized registration data from medical records of patients treated in the pediatric emergency within one year. Descriptive statistics with absolute and relative frequencies was used for the analysis...
2016: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/27528105/clinical-management-of-impacted-and-transmigrated-lower-canines
#19
Klaus Sinko, Stefan Nemec, Rudolf Seemann, Christina Eder-Czembirek
PURPOSE: Impacted, in particular transmigrated, lower canines are rare. If they transmigrate, then the most common treatment is extraction. Alternatively, the native tooth can be preserved; however, management is complex. This report describes a decision-making flowchart (DMFC) with surgical strategies for the management of impacted lower canines. MATERIALS AND METHODS: Fifty-six patients had impacted lower canines, of which 16 were transmigrated. A preliminary version of the DMFC was used for the development of treatment plans to decide which strategy to apply to these complex cases...
July 22, 2016: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27508238/data-from-thermal-testing-of-the-open-source-cryostage
#20
Johannes Lørup Buch, Hans Ramløv
The data presented here is related to the research article "An open source cryostage and software analysis method for detection of antifreeze activity" (Buch and Ramløv, 2016) [1]. The design of the Open Source Cryostage (OSC) is tested in terms of thermal limits, thermal efficiency and electrical efficiency. This article furthermore includes an overview of the electrical circuitry and a flowchart of the software program controlling the temperature of the OSC. The thermal efficiency data is presented here as degrees per volt and maximum cooling capacity...
September 2016: Data in Brief
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