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https://www.readbyqxmd.com/read/29332705/cutaneous-squamous-cell-carcinoma-management-of-advanced-and-high-stage-tumors
#1
REVIEW
Syril Keena T Que, Fiona O Zwald, Chrysalyne D Schmults
While the majority of cutaneous squamous cell carcinomas (cSCCs) can be treated surgically, the additional work-up and treatments indicated for high-risk cSCC remain undefined. In recent years, improvements in tumor staging systems have allowed for the more accurate stratification of tumors into high- and low-risk categories. This insight, along with the publication of cSCC guidelines, brings us closer to the development of a consensus approach. The second article in this continuing medical education series addresses in question and answer format the most common questions related to advanced and high-stage cSCCs, with a simplified flowchart...
February 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29328962/so-you-think-computational-approaches-to-understanding-glycosaminoglycan-protein-interactions-are-too-dry-and-too-rigid-think-again
#2
REVIEW
Nehru Viji Sankaranarayanan, Balaji Nagarajan, Umesh R Desai
Glycosaminoglycans (GAGs) play key roles in virtually all biologic responses through their interaction with proteins. A major challenge in understanding these roles is their massive structural complexity. Computational approaches are extremely useful in navigating this bottleneck and, in some cases, the only avenue to gain comprehensive insight. We discuss the state-of-the-art on computational approaches and present a flowchart to help answer most basic, and some advanced, questions on GAG-protein interactions...
January 9, 2018: Current Opinion in Structural Biology
https://www.readbyqxmd.com/read/29327989/making-it-work-for-everyone-an-evolving-reference-service
#3
Jonquil D Feldman, Emme Lopez, Christine S Gaspard, Karen D Barton, Luis F Barcenes
At an academic health science center, librarians identified problems, weaknesses, and strengths in reference services. The on-call reference schedule was discontinued and a question flowchart was developed for circulation staff. Only research questions were referred to librarians, who would respond if available. Circulation staff perceived the unscheduled, voluntary model was not working well for the patrons or the staff. After two months, the schedule was reinstated with a hybrid version of the previous on-call format...
January 2018: Medical Reference Services Quarterly
https://www.readbyqxmd.com/read/29284203/severe-methylenetetrahydrofolate-reductase-mthfr-deficiency-a-rare-treatable-cause-of-complicated-hereditary-spastic-paraplegia
#4
Alessia Perna, Marcella Masciullo, Anna Modoni, Elena Cellini, Elena Parrini, Enzo Ricci, Alice M Donati, Gabriella Silvestri
BACKGROUND: Juvenile or adult onset forms of severe 5,10-Methylenetetrahydrofolate reductase (MTHFR) deficiency manifesting as complicated hereditary spastic paraplegia have been rarely described. METHODS: Two siblings with mental retardation developed a progressive spastic paraparesis in their late teens. Their diagnostic assessment included extensive neurophysiologic, neuroimaging and metabolic studies. RESULTS: Brain MRI showed occipital white matter alterations; EMG documented a mixed polyneuropathy...
December 28, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29283007/how-to-write-a-systematic-review-of-the-literature
#5
Debajyoti Pati, Lesa N Lorusso
This article provides a step-by-step approach to conducting and reporting systematic literature reviews (SLRs) in the domain of healthcare design and discusses some of the key quality issues associated with SLRs. SLR, as the name implies, is a systematic way of collecting, critically evaluating, integrating, and presenting findings from across multiple research studies on a research question or topic of interest. SLR provides a way to assess the quality level and magnitude of existing evidence on a question or topic of interest...
January 1, 2017: HERD
https://www.readbyqxmd.com/read/29258598/what-methods-do-reviews-of-normative-ethics-literature-use-for-search-selection-analysis-and-synthesis-in-depth-results-from-a-systematic-review-of-reviews
#6
Marcel Mertz, Daniel Strech, Hannes Kahrass
BACKGROUND: (Semi-)systematic approaches to finding, analysing, and synthesising ethics literature on medical topics are still in their infancy. However, our recent systematic review showed that the rate of publication of such (semi-)systematic reviews has increased in the last two decades. This is not only true for reviews of empirical ethics literature, but also for reviews of normative ethics literature. In the latter case, there is currently little in the way of standards and guidance available...
December 19, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29258374/falls-prevention-process-in-assisted-living-communities
#7
DaRae Coughlin, Susan E Nordman-Oliveira, Mary Schlaak, James H Ford
Falls are a significant issue for older adults, and many older adults who once received care in nursing homes now reside in assisted living communities (ALCs). ALC staff needs to address resident falls prevention; however, federal or state requirements or oversight are limited. This research explores falls prevention in Wisconsin ALCs in the context of the Kotter Change Model to identify strategies and inform efforts to establish a more consistent, proactive falls prevention process for ALCs. A mixed methods approach demonstrated inconsistency and variability in the use of falls risk assessments and prevention programs, which led to the development of standardized, proactive falls prevention process flowcharts...
December 1, 2017: Journal of Applied Gerontology: the Official Journal of the Southern Gerontological Society
https://www.readbyqxmd.com/read/29237320/clinical-management-of-women-with-listeriosis-risk-during-pregnancy-a-review-of-national-guidelines
#8
Lisa Pucci, Mario Massacesi, Giuseppina Liuzzi
INTRODUCTION: Listeriosis is an uncommon foodborne infection that may cause moderate maternal illness, but can be extremely serious for the fetus and the newborn. Several guidelines have been elaborated in order to help clinicians on the care of pregnant women with known or suspected exposure to Listeria monocytogenes. The aim of this review is to collect, assess and summarize them, in order to provide a comprehensive overlook and to highlight the grey areas in the guidance that could result in failure to detect some infected but asymptomatic women...
December 13, 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/29222060/cochrane-qualitative-and-implementation-methods-group-guidance-paper-5-reporting-guidelines-for-qualitative-implementation-and-process-evaluation-evidence-syntheses
#9
Kate Flemming, Andrew Booth, Karin Hannes, Margaret Cargo, Jane Noyes
OBJECTIVE: To outline contemporary and novel developments for presentation and reporting of syntheses of qualitative, implementation and process evaluation evidence, and provide recommendations for use of reporting guidelines. STUDY DESIGN AND SETTING: An overview of reporting guidelines for qualitative, implementation and process evaluation evidence syntheses drawing on current international literature and the collective expert knowledge of the Cochrane Qualitative and Implementation Methods Group...
December 5, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/29207961/when-and-how-should-multiple-imputation-be-used-for-handling-missing-data-in-randomised-clinical-trials-a-practical-guide-with-flowcharts
#10
Janus Christian Jakobsen, Christian Gluud, Jørn Wetterslev, Per Winkel
BACKGROUND: Missing data may seriously compromise inferences from randomised clinical trials, especially if missing data are not handled appropriately. The potential bias due to missing data depends on the mechanism causing the data to be missing, and the analytical methods applied to amend the missingness. Therefore, the analysis of trial data with missing values requires careful planning and attention. METHODS: The authors had several meetings and discussions considering optimal ways of handling missing data to minimise the bias potential...
December 6, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/29199505/development-of-a-flowchart-for-risk-assessment-and-allocation-of-preparation-of-monoclonal-antibodies
#11
Tiene Bauters, Johan Vandenbroucke
Monoclonal antibodies have expanded as a novel class of therapeutic agents. In contrast to appropriate guidelines for safe handling of cytotoxics, there are no real standards for the safe handling of monoclonal antibodies. Many questions have arisen whether monoclonal antibodies have to be prepared under controlled circumstances or can be prepared on the ward. We developed a flowchart which provides recommendations for the classification of monoclonal antibodies according to their toxicity profile and takes practical and financial issues into account...
January 1, 2017: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/29182595/identifying-patients-who-will-most-benefit-from-single-photon-emission-computerized-tomography-and-computerized-tomography-after-femoral-neck-fracture
#12
Wenshuai Fan, Liang Zhu, Jifei Chen, Changan Guo, Zuoqin Yan
BACKGROUND Single photon emission computerized tomography and computerized tomography (SPECT/CT) is useful for assessing blood supply within the femoral head after femoral neck fracture, but its use in all femoral neck fracture patients is not feasible. Therefore, the present study aimed to identify the patients for whom SPECT/CT examination will be most beneficial. MATERIAL AND METHODS Sixty-five patients with a unilateral femoral neck fracture who underwent SPECT/CT examination of the hip and were treated via closed reduction and internal fixation with three screws were enrolled between January 2009 and March 2011...
November 28, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29181694/infection-prevention-and-control-in-ultrasound-best-practice-recommendations-from-the-european-society-of-radiology-ultrasound-working-group
#13
Christiane M Nyhsen, Hilary Humphreys, Roland J Koerner, Nicolas Grenier, Adrian Brady, Paul Sidhu, Carlos Nicolau, Gerhard Mostbeck, Mirko D'Onofrio, Afshin Gangi, Michel Claudon
OBJECTIVES: The objective of these recommendations is to highlight the importance of infection prevention and control in ultrasound (US), including diagnostic and interventional settings. METHODS: Review of available publications and discussion within a multidisciplinary group consistent of radiologists and microbiologists, in consultation with European patient and industry representatives. RECOMMENDATIONS: Good basic hygiene standards are essential...
November 27, 2017: Insights Into Imaging
https://www.readbyqxmd.com/read/29152516/how-do-i-write-a-scientific-article-a-personal-perspective
#14
Giuseppe Lippi
Scientific writing is not an easy task. Although there is no single and universally agreed strategy for assembling a successful scientific article, it is undeniable that some basic notions, gathered after decades of experience, may help increasing the chance of acceptance of a scientific manuscript. Therefore, the purpose of this article is to present a personal and arbitrary perspective on how to write a scientific article, entailing a tentative flowchart and a checklist describing the most important aspects characterizing each section of the manuscript...
October 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29135618/pathway-for-the-management-of-hyperglycemia-in-the-cardiac-care-unit
#15
Seyed Hamed Hosseini Dehkordi, Jeanine Albu, Emad F Aziz, Eyal Herzog
Inpatient hyperglycemia has been associated with increased morbidity and mortality in critically ill patients. Optimal control of blood glucose (BG) levels using insulin infusion protocols has been shown to improve clinical outcomes. Protocols have been developed to prescribe a safe and effective rate of insulin infusion for optimal control of BG levels; however, a major obstacle in their implementation is their complexity. We have revised and updated our previously published pathway for the management of hyperglycemia, which introduces the "wheel" concept for insulin dosing...
December 2017: Critical Pathways in Cardiology
https://www.readbyqxmd.com/read/29134235/correction-to-the-p-n-positive-to-negative-links-ratio-in-complex-networks-a-promising-in-silico-biomarker-for-detecting-changes-occurring-in-the-human-microbiome
#16
Zhanshan Sam Ma
The original version of this article unfortunately contained a missing image. The flowchart was not captured in PDF version. The original article was corrected.
November 13, 2017: Microbial Ecology
https://www.readbyqxmd.com/read/29129000/health-literacy-in-type-2-diabetes-patients-a-systematic-review-of-systematic-reviews
#17
Rosario Caruso, Arianna Magon, Irene Baroni, Federica Dellafiore, Cristina Arrigoni, Francesco Pittella, Davide Ausili
Aim To summarize, critically review, and interpret the evidence related to the systematic reviews on health literacy (HL) amongst type 2 diabetes mellitus (T2DM). Methods The methodology for this study consisted of a systematic review of systematic reviews, using the PRISMA statement and flowchart to select studies, and searching on PubMed, CINAHL, Scopus, and Cochrane. The search covered the period between January 2006 and June 2016. Results From the 115 identified record by the queries, only six systematic reviews were included, following a quality evaluation using AMSTAR...
November 11, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/29123012/prostate-cancer-molecular-imaging-standardized-evaluation-promise-proposed-mitnm-classification-for-the-interpretation-of-psma-ligand-pet-ct
#18
Matthias Eiber, Ken Herrmann, Jeremie Calais, Boris Hadaschihk, Frederik L Giesel, Markus Hartenbach, Thomas Hope, Robert Reiter, Tobias Maurer, Wolfgang A Weber, Wolfgang P Fendler
Prostate-specific membrane antigen (PSMA)-ligand positron emission tomography (PET)-imaging provides unprecedented accuracy for whole body staging of prostate cancer. As PSMA-ligand PET/computed tomography (CT) is increasingly adopted in clinical trials and routine practice worldwide, a unified language for image reporting is urgently needed. We propose a molecular imaging tumor, node and metastasis system (miTNM Version 1.0) as standardized reporting framework for PSMA-ligand PET/CT or PET/magnetic resonance imaging (MRI)...
November 9, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29110638/application-of-the-2016-diagnostic-approach-for-autoimmune-encephalitis-from-lancet-neurology-to-chinese-patients
#19
Lin Li, Lin Sun, Rong Du, Yuanchu Zheng, Feifei Dai, Qiuying Ma, Jiawei Wang
BACKGROUND: A unified clinical approach to diagnose autoimmune encephalitis was published in Lancet Neurology in 2016. Purpose of our study is to examine the feasibility and reasonability of the 2016 "A clinical approach to diagnosis of autoimmune encephalitis" in China with a retrospective study. METHODS: We retrospectively collected 95 cases of autoimmune encephalitis and non autoimmune encephalitis cases with detailed clinical data from Beijing Tongren Hospital and the China National Knowledge Infrastructure (CNKI)...
November 6, 2017: BMC Neurology
https://www.readbyqxmd.com/read/29106452/acute-aortic-syndromes-diagnosis-and-management-an-update
#20
Eduardo Bossone, Troy M LaBounty, Kim A Eagle
Acute aortic syndromes (AAS) encompass a constellation of life-threatening medical conditions including classic acute aortic dissection (AAD), intramural haematoma, and penetrating atherosclerotic aortic ulcer. Given the non-specific symptoms and physical signs, a high clinical index of suspicion is necessary to detect the disease before irreversible lethal complications occur. In order to reduce the diagnostic time delay, a comprehensive flowchart for decision-making based on pre-test sensitivity of AAS has been designed by the European Society of Cardiology guidelines on aortic diseases and should be thus applied in the emergency scenario...
June 30, 2017: European Heart Journal
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