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https://www.readbyqxmd.com/read/28103826/tracking-the-origin-of-simultaneous-endometrial-and-ovarian-cancer-by-next-generation-sequencing-a-case-report
#1
Nadejda Valtcheva, Franziska M Lang, Aurelia Noske, Eleftherios P Samartzis, Anna-Maria Schmidt, Elisa Bellini, Daniel Fink, Holger Moch, Markus Rechsteiner, Konstantin J Dedes, Peter J Wild
BACKGROUND: Endometrioid adenocarcinoma of the uterus and ovarian endometrioid carcinoma share many morphological and molecular features. Differentiation between simultaneous primary carcinomas and ovarian metastases of an endometrial cancer may be very challenging but is essential for prognostic and therapeutic considerations. CASE PRESENTATION: In the present case study of a 33 year-old patient we used targeted amplicon next-generation re-sequencing for clarifying the origin of synchronous endometrioid cancer of the corpus uteri and the left ovary...
January 19, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28101463/development-of-a-novel-human-single-chain-antibody-against-egfrviii-antigen-by-phage-display-technology
#2
Leila Rahbarnia, Safar Farajnia, Hossein Babaei, Jafar Majidi, Bahman Akbari, Shiva Ahdi Khosroshahi
Purpose: EGFRvIII as the most common mutant variant of the epidermal growth factor receptor is resulting from deletion of exons 2-7 in the coding sequence and junction of exons 1 and 8 through a novel glycine residue. EGFRvIII is highly expressed in glioblastoma, carcinoma of the breast, ovary, and lung but not in normal cells. The aim of the present study was identification of a novel single chain antibody against EGFRvIII as a promising target for cancer therapy. Methods: In this study, a synthetic peptide corresponding to EGFRvIII protein was used for screening a naive human scFv phage library...
December 2016: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28100947/solitary-splenic-metastasis-from-a-mucinous-adenocarcinoma-of-the-cecum-a-case-report
#3
Maximiliano Lo Tartaro, Miguel A Cardona, Maria S Serrano, Mario Cantin, Nicolas Ernesto Ottone
Reports of cases of splenic metastasis are very rare, even more so when they are derived from a mucinous adenocarcinoma of the cecum. The most common presentation of a solitary splenic metastasis is from lung primary tumors, endometrium, ovary, cervix, stomach, colon, breast, bladder, and skin. We report the case of an 84-year-old woman with a solitary splenic metastasis from a mucinous adenocarcinoma of the cecum. Until this work, only 18 cases of solitary splenic metastases from colorectal carcinomas have been described in the literature...
December 2016: Indian Journal of Surgery
https://www.readbyqxmd.com/read/28098572/metastatic-organotropism-an-intrinsic-property-of-breast-cancer-molecular-subtypes
#4
Shi Wei, Gene P Siegal
It has long been known that some cancers have the propensity to metastasize to certain organs thus creating a nonrandom distribution of sites for distant relapse, a phenomenon known as "metastatic organotropism." Some of these examples include ovary primary to abdominal cavity, prostate primary to bone, and pancreas primary to liver. In contrast, other tumor types, such as mammary and renal cell carcinoma, can relapse in multiple organs although approximately half of advanced breast cancers metastasize to bone...
January 16, 2017: Advances in Anatomic Pathology
https://www.readbyqxmd.com/read/28087476/phospholipase-d-mrna-expression-and-clinical-role-in-high-grade-serous-carcinoma
#5
Keren Harel-Dassa, Saul Yedgar, Claes G Tropé, Ben Davidson, Reuven Reich
This objective of this study was to analyze the expression and clinical role of phospholipase D (PLD) in high-grade serous carcinoma (HGSC). PLD1 and PLD2 isoform expression was studied in 125 HGSC specimens (73 effusions, 28 ovarian tumors, 24 solid metastases) using quantitative real-time reverse-transcription polymerase chain reaction (qRT-PCR). Expression levels were analyzed for association with clinicopathologic parameters, including chemoresponse, and survival. PLD1 and PLD2 isoforms were found in the majority of specimens at all anatomic sites and their levels were strongly positively related (P<...
January 10, 2017: Human Pathology
https://www.readbyqxmd.com/read/28072594/genetics-consultation-rates-following-a-diagnosis-of-high-grade-serous-ovarian-carcinoma-in-the-canadian-province-of-ontario
#6
Jacob McGee, Karen Panabaker, Sean Leonard, Peter Ainsworth, Laurie Elit, Salimah Z Shariff
OBJECTIVE: In 2001, the province of Ontario expanded cancer genetic testing eligibility to include all women with high-grade serous ovarian carcinoma (HGSC) of the ovary, fallopian tube, and peritoneum. The aim of this study was to determine the proportion of women who attended genetics counseling for consideration of BRCA1/2 gene analysis. We also sought to examine if regional differences in consultation rate exist across administrative health regions in the province of Ontario. METHODS: We identified all women with a pathological diagnosis of HGSC in the province of Ontario between 1997 until 2011...
January 9, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28071629/clinical-characteristics-with-patterns-of-relapse-and-survival-analysis-of-ovarian-clear-cell-carcinoma
#7
S Kaur, R A Kerkar, A Maheshwari, T S Shylasree, S Gupta, K Deodhar
AIMS: To analyze clinical characteristics, patterns of relapse, and treatment outcomes of clearcell carcinoma of the ovary (CCO). MATERIALS AND METHODS: Case files of 51 patients diagnosed with CCO between 2003 and 2010 were reviewed. RESULTS: The median age at diagnosis was 48 years (27-64 years). Fifty percent presented with nonspecific gastrointestinal symptoms. The median serum Ca125 was 74 IU/ml (6-1567 U/ml). Optimal cytoreduction was achieved in 32 (62...
April 2016: Indian Journal of Cancer
https://www.readbyqxmd.com/read/28066838/neuroendocrine-carcinoma-of-the-ovotestis-a-case-report-and-review-of-literatures
#8
Tahereh Ashrafganjoei, Ainaz Sourati, Mahdiss Mohamadianamiri
BACKGROUND: Neuroendocine carcinoma of the gynecologic tract is rare and poses a significant clinical challenge because of tumor heterogeneity and lack of standardized guidelines for treatment. Ovotestis refers to the histology of a gonad that contains both ovarian follicles and testicular tubular elements. Ovotesticular disorder of sexual development occurs in fewer than 10% of all disorders of sexual development. Gonadal tumors with malignant potential occur in 2.6% of all cases of ovotesticular disorder of sexual development...
December 2016: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/28062021/endometrioid-carcinoma-of-the-ovary-outcomes-compared-to-serous-carcinoma-after-10-years-of-follow-up
#9
Geneviève Bouchard-Fortier, Tony Panzarella, Barry Rosen, William Chapman, Lilian T Gien
OBJECTIVES: The prognostic significance of endometrioid ovarian cancer is unclear. In this study we compared rates of overall survival (OS) and disease-free survival between patients with endometrioid and serous ovarian cancers using long-term follow-up data. METHODS: We included patients with endometrioid or serous ovarian cancers diagnosed at a single regional cancer centre between 1988 and 2006. Data on baseline and treatment characteristics were collected retrospectively...
January 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28060250/murine-experimental-model-of-original-tumor-development-and-peritoneal-metastasis-via-orthotopic-inoculation-with-ovarian-carcinoma-cells
#10
Yoshihiro Koya, Hiroaki Kajiyama, Wenting Liu, Kiyosumi Shibata, Takeshi Senga, Fumitaka Kikkawa
Epithelial ovarian carcinoma (EOC) is associated with a poor prognosis because it shows peritoneal dissemination. To improve the prognosis, it is important to control peritoneal dissemination. However, it is still unclear how tumor cells detach from primary lesions and attach to the mesothelium. The establishment of an appropriate animal model is needed to gain an understanding of the mechanism of peritoneal dissemination in vivo. In the current study, we introduce the process from the local injection of EOC cells into the murine ovarian surface to the development of metastasis, including the peritoneum and distant organs...
December 9, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28059101/steroid-hormone-synthesis-by-the-ovarian-stroma-surrounding-epithelial-ovarian-tumors-a-potential-mechanism-in-ovarian-tumorigenesis
#11
Luis Z Blanco, Elisabetta Kuhn, Jane C Morrison, Asli Bahadirli-Talbott, Anne Smith-Sehdev, Robert J Kurman
Epithelial ovarian tumors are responsive to steroid hormone stimulation and the ovarian stroma may have a direct role in this process. We evaluated immunohistochemical markers of sex-steroid differentiation and steroidogenesis (calretinin, inhibin, steroidogenic factor 1), steroid enzymes involved in hormone biosynthesis (CYP17, CYP19, HSD17β1, AKR1C3), and hormone receptors (estrogen receptor, progesterone receptor, and androgen receptor) in 101 epithelial ovarian tumors and in normal structures implicated in ovarian carcinogenesis (ovarian surface epithelium and cortical inclusion cysts) in an attempt to elucidate this process...
January 6, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28050596/an-ovarian-mature-cystic-teratoma-evolving-in-squamous-cell-carcinoma-a-case-report-and-review-of-the-literature
#12
REVIEW
C Goudeli, A Varytimiadi, N Koufopoulos, J Syrios, E Terzakis
Mature cystic teratomas (MCT), also known as dermoid cysts, are the most common ovarian germ cell tumors and the most common ovarian neoplasms in patients younger than 20 years. Malignant transformation (MT) is a rare complication of MCTs which may occur in 1-2% of the cases. Squamous cell carcinoma (SCC) is the most frequent histology arising from MCTs and its appearance depends on diverse risk factors such as patient's age, the size of the tumor and levels of serum tumor markers. Diagnosis and treatment constitute a big challenge due to the rarity and the aggressive course of this entity...
February 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28041594/malignant-and-borderline-epithelial-ovarian-tumors-in-the-pediatric-and-adolescent-population
#13
Dimitrios Nasioudis, Michail Alevizakos, Kevin Holcomb, Steven S Witkin
OBJECTIVES: Malignant and borderline ovarian tumors of epithelial origin are rarely encountered among prepubertal girls and adolescents. The aim of this population-based study was to elucidate their clinicopathological characteristics and prognosis using a multi-institutional tumor registry. STUDY DESIGN AND OUTCOMES: The National Cancer Institute's Surveillance, Epidemiology, and End Results database was accessed and a cohort of females aged <=19years old, diagnosed between 1988 and 2013 with a borderline ovarian tumor (BOT) or a malignant epithelial ovarian carcinoma (EOC) was accessed...
February 2017: Maturitas
https://www.readbyqxmd.com/read/28038913/rlj-rgd3-induces-apoptosis-via-the-mitochondrial-dependent-pathway-and-inhibits-adhesion-migration-and-invasion-of-human-heya8-cells-via-fak-pathway
#14
Qi Jiang, Qingwei Li, Jianmei Han, Meng Gou, Yuanyuan Zheng, Bowen Li, Rong Xiao, Jihong Wang
Ovarian carcinoma is a tumor derived from ovary, which brings relatively higher mortality rate among the fatal gynecological cancers. Recently, lots of studies have concentrated on the anti-tumor effects of Arg-Gly-Asp (RGD) motif containing peptides due to their integrin binding properties. In order to meet the criterion of genetic engineering drugs, a recombinant RGD toxin protein (rLj-RGD3) without a His-tag was cloned from the buccal glands of Lampetra japonica in the present study. After endotoxin removal, the His-tag removed rLj-RGD3 was shown to inhibit the proliferation of HeyA8 cells...
December 27, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28025670/ovarian-borderline-tumors-in-the-2014-who-classification-evolving-concepts-and-diagnostic-criteria
#15
REVIEW
Steffen Hauptmann, Katrin Friedrich, Raymond Redline, Stefanie Avril
Borderline ovarian tumors (BOT) are uncommon but not rare epithelial ovarian neoplasms, intermediate between benign and malignant categories. Since BOT were first identified >40 years ago, they have inspired controversies disproportionate to their incidence. This review discusses diagnostic criteria for the histologic subtypes of BOT, highlighting areas of diagnostic challenges, ongoing controversies, and changes in terminology implemented by the recent 2014 WHO Classification of Tumours of the Female Genital Organs...
December 27, 2016: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28018460/unusual-malignant-neoplasms-of-ovary-in-children-two-cases-report
#16
Ali Ghribi, Aicha Bouden, Manef Gasmi, Mourad Hamzaoui
Sex cord tumors with annular tubules are known to originate from the sex cord of embryonic gonads that synthesize Sertoli cells, Leydig cells, granulosa cells, and theca cells of the ovarian stroma, while ovarian small cell carcinoma of the hypercalcemic type is a type of neuroendocrine tumor. Both these tumors are uncommon, potentially malignant neoplasms in children. We report the case of a sex cord tumor with annular tubules in an 11-year-old girl and a case of small cell carcinoma of the hypercalcemic type in a 10-year-old girl...
November 2016: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/28013223/site-1-protease-is-required-for-the-generation-of-soluble-pro-renin-receptor
#17
Tsutomu Nakagawa, Chiharu Suzuki-Nakagawa, Akiko Watanabe, Eriko Asami, Mizuki Matsumoto, Mami Nakano, Akio Ebihara, Mohammad Nasir Uddin, Fumiaki Suzuki
The extracellular domain of the (pro)renin receptor [(P)RR] is cleaved to generate the soluble form of (P)RR [s(P)RR]. Multiple clinical studies have revealed the association between serum/plasma s(P)RR levels and certain diseases, thereby suggesting a potential role for s(P)RR as a disease biomarker. Here, we investigated whether site-1 protease (S1P) is responsible for cleaving (P)RR to generate s(P)RR. Reduction of endogenous S1P with siRNA attenuated s(P)RR generation in Chinese hamster ovary (CHO) cells exogenously expressing human (P)RR with a C-terminal decahistidine tag [CHO/h(P)RR-10His cells]; conversely, overexpression of S1P by transient transfection increased s(P)RR generation...
December 24, 2016: Journal of Biochemistry
https://www.readbyqxmd.com/read/28007588/the-role-of-fallopian-tubes-in-the-development-of-ovarian-cancer
#18
REVIEW
Camila Corzo, Maria D Iniesta, Maria Guadalupe Patrono, Karen H Lu, Pedro T Ramirez
Ovarian cancer is the leading cause of death from gynecologic malignancy and the fifth cause of cancer death in women in the United States. The most common and lethal histologic subtype of epithelial ovarian cancer is high-grade serous carcinoma (HGSC), and it generally presents at advanced stage and it may be associated with BRCA1 and BRCA2 mutations. Historically, HGSC was thought to originate from the ovarian epithelial cells. However, more recently, there is growing evidence to support that the vast majority of ovarian cancers originate in the fallopian tube epithelium in both high-risk women and in the general population...
December 19, 2016: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27998689/plasma-membrane-organization-and-dynamics-is-probe-and-cell-line-dependent
#19
Shuangru Huang, Shi Ying Lim, Anjali Gupta, Nirmalya Bag, Thorsten Wohland
The action and interaction of membrane receptor proteins take place within the plasma membrane. The plasma membrane, however, is not a passive matrix. It rather takes an active role and regulates receptor distribution and function by its composition and the interaction of its lipid components with embedded and surrounding proteins. Furthermore, it is not a homogenous fluid but contains lipid and protein domains of various sizes and characteristic lifetimes which are important in regulating receptor function and signaling...
December 18, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27994692/incidental-findings-of-intense-radioiodine-uptake-in-struma-ovarii-and-bilateral-nonlactating-breasts-simultaneously-on-postablation-131-i-spect-ct-for-papillary-thyroid-cancer
#20
Hye-Kyung Shim, Mi Ra Kim
A 52-year-old woman diagnosed with papillary thyroid carcinoma was referred for (131)I therapy following total thyroidectomy. She was given 4,810 MBq (130 mCi) of (131)I following 4 weeks of thyroid hormone withdrawal. A posttherapy scan showed intense, focal activity in the pelvis and intense, diffuse activity on both sides of the chest, which was localized to the right ovary and both breasts on SPECT/CT examination. She had bilateral nipple pain and a history of antidopaminergic drugs as combination medication for her rheumatoid arthritis and prokinetics during radioiodine therapy...
December 2016: Nuclear Medicine and Molecular Imaging
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