keyword
MENU ▼
Read by QxMD icon Read
search

Fallypride

keyword
https://www.readbyqxmd.com/read/27634830/cigarette-use-and-striatal-dopamine-d2-3-receptors-possible-role-in-the-link-between-smoking-and-nicotine-dependence
#1
Kyoji Okita, Mark A Mandelkern, Edythe D London
BACKGROUND: Cigarette smoking induces dopamine release in the striatum, and smoking- or nicotine-induced ventral striatal dopamine release is correlated with nicotine dependence. Smokers also exhibit lower dopamine D2/3 (D2 and D3) receptor availability (BPND) in the dorsal striatum than nonsmokers. Negative correlations of striatal dopamine D2/3 BPND with smoking exposure and nicotine dependence, therefore, might be expected, but have not been tested. METHODS: Twenty smokers had positron emission tomography scans with [(18)F]fallypride to measure dopamine D2/3 BPND in ventral and dorsal regions of the striatum, and provided self-report Measures of recent and lifetime smoking and of nicotine dependence...
September 15, 2016: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27408789/occupancy-of-pramipexole-sifrol-at-cerebral-dopamine-d2-3-receptors-in-parkinson-s-disease-patients
#2
Angela Deutschländer, Christian la Fougère, Kai Boetzel, Nathalie L Albert, Franz-Josef Gildehaus, Peter Bartenstein, Guoming Xiong, Paul Cumming
Whereas positron emission tomography (PET) with the antagonist ligand [(18)F]fallypride reveals the composite of dopamine D2 and D3 receptors in brain, treatment of Parkinson's disease (PD) patients with the D3-prefering agonist pramipexole should result in preferential occupancy in the nucleus accumbens, where the D3-subtype is most abundant. To test this prediction we obtained pairs of [(18)F]fallypride PET recordings in a group of nine PD patients, first in a condition of treatment as usual with pramipexole (ON-Sifrol; 3 × 0...
2016: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27396374/acute-effect-of-intravenously-applied-alcohol-in-the-human-striatal-and-extrastriatal-d2-d3-dopamine-system
#3
Philippe Pfeifer, Oliver Tüscher, Hans Georg Buchholz, Gerhard Gründer, Ingo Vernaleken, Michael Paulzen, Ulrich S Zimmermann, Stephan Maus, Klaus Lieb, Thomas Eggermann, Christoph Fehr, Mathias Schreckenberger
Investigations on the acute effects of alcohol in the human mesolimbic dopamine D2 /D3 receptor system have yielded conflicting results. With respect to the effects of alcohol on extrastriatal D2 /D3 dopamine receptors no investigations have been reported yet. Therefore we applied PET imaging using the postsynaptic dopamine D2 /D3 receptor ligand [(18) F]fallypride addressing the question, whether intravenously applied alcohol stimulates the extrastriatal and striatal dopamine system. We measured subjective effects of alcohol and made correlation analyses with the striatal and extrastriatal D2 /D3 binding potential...
July 11, 2016: Addiction Biology
https://www.readbyqxmd.com/read/27329684/sex-differences-in-midbrain-dopamine-d2-type-receptor-availability-and-association-with-nicotine-dependence
#4
Kyoji Okita, Nicole Petersen, Chelsea L Robertson, Andy C Dean, Mark A Mandelkern, Edythe D London
Women differ from men in smoking-related behaviors, among them a greater difficulty in quitting smoking. Unlike female smokers, male smokers have lower striatal dopamine D2-type receptor availability (binding potential, BPND) than nonsmokers and exhibit greater smoking-induced striatal dopamine release. Because dopamine D2-type autoreceptors in the midbrain influence striatal dopamine release, a function that has been linked to addiction, we tested for sex differences in midbrain dopamine D2-type receptor BPND and in relationships between midbrain BPND, nicotine dependence and striatal dopamine D2-type receptor BPND...
November 2016: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27208860/associations-between-dopamine-d2-receptor-availability-and-bmi-depend-on-age
#5
Linh C Dang, Gregory R Samanez-Larkin, Jaime J Castrellon, Scott F Perkins, Ronald L Cowan, David H Zald
OBJECTIVE: The dopamine D2/3 receptor subtypes (DRD2/3) are the most widely studied neurotransmitter biomarker in research on obesity, but results to date have been inconsistent, have typically involved small samples, and have rarely accounted for subjects' ages despite the large impact of age on DRD2/3 levels. We aimed to clarify the relation between DRD2/3 availability and BMI by examining this association in a large sample of subjects with BMI spanning the continuum from underweight to extremely obese...
September 2016: NeuroImage
https://www.readbyqxmd.com/read/27199355/noninvasive-pet-imaging-and-tracking-of-engineered-human-muscle-precursor-cells-for-skeletal-muscle-tissue-engineering
#6
Deana Haralampieva, Thomas Betzel, Ivana Dinulovic, Souzan Salemi, Meline Stoelting, Stefanie D Krämer, Roger Schibli, Tullio Sulser, Christoph Handschin, Daniel Eberli, Simon M Ametamey
UNLABELLED: Transplantation of human muscle precursor cells (hMPCs) is envisioned for the treatment of various muscle diseases. However, a feasible noninvasive tool to monitor cell survival, migration, and integration into the host tissue is still missing. METHODS: In this study, we designed an adenoviral delivery system to genetically modify hMPCs to express a signaling-deficient form of human dopamine D2 receptor (hD2R). The gene expression levels of the receptor were evaluated by reverse transcriptase polymerase chain reaction, and infection efficiency was evaluated by fluorescent microscopy...
September 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27174408/variability-in-paralimbic-dopamine-signaling-correlates-with-subjective-responses-to-d-amphetamine
#7
Christopher T Smith, Linh C Dang, Ronald L Cowan, Robert M Kessler, David H Zald
Subjective responses to psychostimulants vary, the basis of which is poorly understood, especially in relation to possible cortical contributions. Here, we tested for relationships between participants' positive subjective responses to oral d-amphetamine (dAMPH) versus placebo and variability in striatal and extrastriatal dopamine (DA) receptor availability and release, measured via positron emission tomography (PET) with the radiotracer (18)F-fallypride. Analyses focused on 35 healthy adult participants showing positive subjective effects to dAMPH measured via the Drug Effects Questionnaire (DEQ) Feel, Like, High, and Want More subscales (Responders), and were repeated after inclusion of 11 subjects who lacked subjective responses...
September 2016: Neuropharmacology
https://www.readbyqxmd.com/read/27103832/use-of-micro-positron-emission-tomography-with-18-f-fallypride-to-measure-the-levels-of-dopamine-receptor-d2-and-18-f-fdg-as-molecular-imaging-tracer-in-the-pituitary-glands-and-prolactinomas-of-fischer-344-rats
#8
Ping Li, Songbai Gui, Lei Cao, Hua Gao, Jiwei Bai, Chuzhong Li, Yazhuo Zhang
Dopamine receptor-D2 (DRD2) is the most important drug target in prolactinoma. The aim of this current study was to investigate the role of using micro-positron emission tomography (micro-PET) with (18)F-fallypride and (18)F-fluorodeoxyglucose ((18)F-FDG) as molecular imaging tracer in the pituitary glands and prolactinomas of Fischer-344 (F344) rats and detect the difference of the levels of DRD2 in the pituitary glands and prolactinomas of F344 rat prolactinoma models. Female F344 rat prolactinoma models were established by subcutaneous administration of 15 mg 17β-estradiol for 8 weeks...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27007554/early-life-stress-affects-stress-related-prefrontal-dopamine-activity-in-healthy-adults-but-not-in-individuals-with-psychotic-disorder
#9
Zuzana Kasanova, Dennis Hernaus, Thomas Vaessen, Thérèse van Amelsvoort, Oliver Winz, Alexander Heinzel, Jens Pruessner, Felix M Mottaghy, Dina Collip, Inez Myin-Germeys
Early life stress may have a lasting impact on the developmental programming of the dopamine (DA) system implicated in psychosis. Early adversity could promote resilience by calibrating the prefrontal stress-regulatory dopaminergic neurotransmission to improve the individual's fit with the predicted stressful environment. Aberrant reactivity to such match between proximal and distal environments may, however, enhance psychosis disease risk. We explored the combined effects of childhood adversity and adult stress by exposing 12 unmedicated individuals with a diagnosis of non-affective psychotic disorder (NAPD) and 12 healthy controls (HC) to psychosocial stress during an [18F]fallypride positron emission tomography...
2016: PloS One
https://www.readbyqxmd.com/read/26900792/cocaine-cue-induced-dopamine-release-in-the-human-prefrontal-cortex
#10
Michele S Milella, Aryandokht Fotros, Paul Gravel, Kevin F Casey, Kevin Larcher, Jeroen A J Verhaeghe, Sylvia M L Cox, Andrew J Reader, Alain Dagher, Chawki Benkelfat, Marco Leyton
BACKGROUND: Accumulating evidence indicates that drug-related cues can induce dopamine (DA) release in the striatum of substance abusers. Whether these same cues provoke DA release in the human prefrontal cortex remains unknown. METHODS: We used high-resolution positron emission tomography with [18F]fallypride to measure cortical and striatal DA D2/3 receptor availability in the presence versus absence of drug-related cues in volunteers with current cocaine dependence...
August 2016: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/26889225/evaluation-of-the-early-response-and-mechanism-of-treatment-of-parkinson-s-disease-with-l-dopa-using-18-f-fallypride-micro-positron-emission-tomography-scanning
#11
Yi-Hua Fa, Jian-Qiang Ni, Xiao-Jin Wu, Jia-Qing Tan, Yi-Wei Wu
The aim of the present study was to investigate the use of (18)F-fallypride micro-positron emission tomography (micro-PET) imaging in the evaluation of the early therapeutic efficacy of L-dopa in the treatment of Parkinson's disease (PD) and the underlying mechanism. (18)F-fallypride was synthesized and its specific binding with dopamine (DA) receptors in normal mouse brain was studied. Following the establishment of a mouse model of PD, the animals were divided into normal control, PD model and L-dopa treatment groups...
January 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/26880595/emotion-dysregulation-and-amygdala-dopamine-d2-type-receptor-availability-in-methamphetamine-users
#12
Kyoji Okita, Dara G Ghahremani, Doris E Payer, Chelsea L Robertson, Andy C Dean, Mark A Mandelkern, Edythe D London
BACKGROUND: Individuals who use methamphetamine chronically exhibit emotional and dopaminergic neurochemical deficits. Although the amygdala has an important role in emotion processing and receives dopaminergic innervation, little is known about how dopamine transmission in this region contributes to emotion regulation. This investigation aimed to evaluate emotion regulation in subjects who met DSM-IV criteria for methamphetamine dependence, and to test for a relationship between self-reports of difficulty in emotion regulation and D2-type dopamine receptor availability in the amygdala...
April 1, 2016: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/26830141/midbrain-functional-connectivity-and-ventral-striatal-dopamine-d2-type-receptors-link-to-impulsivity-in-methamphetamine-users
#13
M Kohno, K Okita, A M Morales, C L Robertson, A C Dean, D G Ghahremani, F W Sabb, R A Rawson, M A Mandelkern, R M Bilder, E D London
Stimulant use disorders are associated with deficits in striatal dopamine receptor availability, abnormalities in mesocorticolimbic resting-state functional connectivity (RSFC) and impulsivity. In methamphetamine-dependent research participants, impulsivity is correlated negatively with striatal D2-type receptor availability, and mesocorticolimbic RSFC is stronger than that in controls. The extent to which these features of methamphetamine dependence are interrelated, however, is unknown. This question was addressed in two studies...
February 2, 2016: Molecular Psychiatry
https://www.readbyqxmd.com/read/26657223/striatal-dopamine-d2-d3-receptor-availability-is-associated-with-executive-function-in-healthy-controls-but-not-methamphetamine-users
#14
Michael E Ballard, Andy C Dean, Mark A Mandelkern, Edythe D London
BACKGROUND: Dopamine D2/D3 receptor availability in the striatum has been linked with executive function in healthy individuals, and is below control levels among drug addicts, possibly contributing to diminished executive function in the latter group. This study tested for an association of striatal D2/D3 receptor availability with a measure of executive function among research participants who met DSM-IV criteria for methamphetamine dependence. METHODS: Methamphetamine users and non-user controls (n = 18 per group) completed the Wisconsin Card Sorting Test and positron emission tomography with [18F]fallypride...
2015: PloS One
https://www.readbyqxmd.com/read/26657175/relationship-of-alexithymia-ratings-to-dopamine-d2-type-receptors-in-anterior-cingulate-and-insula-of-healthy-control-subjects-but-not-methamphetamine-dependent-individuals
#15
Kyoji Okita, Dara G Ghahremani, Doris E Payer, Chelsea L Robertson, Mark A Mandelkern, Edythe D London
BACKGROUND: Individuals with substance-use disorders exhibit emotional problems, including deficits in emotion recognition and processing, and this class of disorders also has been linked to deficits in dopaminergic markers in the brain. Because associations between these phenomena have not been explored, we compared a group of recently abstinent methamphetamine-dependent individuals (n=23) with a healthy-control group (n=17) on dopamine D2-type receptor availability, measured using positron emission tomography with [(18)F]fallypride...
May 2016: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/26544593/reduced-d2-d3-receptor-binding-of-extrastriatal-and-striatal-regions-in-temporal-lobe-epilepsy
#16
COMPARATIVE STUDY
Viviane E Bernedo Paredes, Hans-Georg Buchholz, Martin Gartenschläger, Markus Breimhorst, Mathias Schreckenberger, Konrad J Werhahn
OBJECTIVE: Dopamine is an endogenous neuromodulator in cortical circuits and the basal ganglia. In animal models of temporal lobe epilepsy (TLE), seizure threshold is modulated to some extent by dopamine, with D1-receptors having a pro- and D2-receptors an anticonvulsant effect. We aimed to extend our previously reported results on decreased D2/D3 receptor binding in the lateral epileptogenic temporal lobe and to correlate them with demographic and seizure variables to gain a more comprehensive understanding of the underlying involvement of the dopaminergic system in the epileptogenesis of TLE...
2015: PloS One
https://www.readbyqxmd.com/read/26503310/effect-of-exercise-training-on-striatal-dopamine-d2-d3-receptors-in-methamphetamine-users-during-behavioral-treatment
#17
Chelsea L Robertson, Kenji Ishibashi, Joy Chudzynski, Larissa J Mooney, Richard A Rawson, Brett A Dolezal, Christopher B Cooper, Amira K Brown, Mark A Mandelkern, Edythe D London
Methamphetamine use disorder is associated with striatal dopaminergic deficits that have been linked to poor treatment outcomes, identifying these deficits as an important therapeutic target. Exercise attenuates methamphetamine-induced neurochemical damage in the rat brain, and a preliminary observation suggests that exercise increases striatal D2/D3 receptor availability (measured as nondisplaceable binding potential (BPND)) in patients with Parkinson's disease. The goal of this study was to evaluate whether adding an exercise training program to an inpatient behavioral intervention for methamphetamine use disorder reverses deficits in striatal D2/D3 receptors...
May 2016: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/26248198/detecting-and-estimating-head-motion-in-brain-pet-acquisitions-using-raw-time-of-flight-pet-data
#18
P J Schleyer, J T Dunn, S Reeves, S Brownings, P K Marsden, K Thielemans
Head motion during brain PET imaging is not uncommon and can negatively affect image quality. Motion correction techniques typically either use hardware to prospectively measure head motion, or they divide the acquisition into short fixed-frames and then align and combine these to produce a motion free image. The aim of this work was to retrospectively detect when motion occurred in PET data without the use of motion detection hardware, and then align the frames defined by these motion occurrences. We describe two methods that use either principal component analysis or the motion induced spatial displacements over time to detect motion in raw time-of-flight PET data...
August 21, 2015: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/26232153/striatal-and-extrastriatal-dopamine-release-in-the-common-marmoset-brain-measured-by-positron-emission-tomography-and-18-f-fallypride
#19
Miho Ota, Shintaro Ogawa, Koichi Kato, Chiaki Masuda, Hiroshi Kunugi
Previous studies have demonstrated that patients with schizophrenia show greater sensitivity to psychostimulants than healthy subjects. Sensitization to psychostimulants and resultant alteration of dopaminergic neurotransmission in rodents has been suggested as a useful model of schizophrenia. This study sought to examine the use of methylphenidate as a psychostimulant to induce dopamine release and that of [(18)F]fallypride as a radioligand to quantify the release in a primate model of schizophrenia. Four common marmosets were scanned by positron emission tomography twice, before and after methylphenidate challenge, to evaluate dopamine release...
December 2015: Neuroscience Research
https://www.readbyqxmd.com/read/26015960/quantitative-noninvasive-in-vivo-longitudinal-monitoring-of-gene-expression-in-the-brain-by-co-aav-transduction-with-a-pet-reporter-gene
#20
Sea Young Yoon, Carlos Gay-Antaki, Datta E Ponde, Harish Poptani, Charles H Vite, John H Wolfe
In vivo imaging of vector transgene expression would be particularly valuable for repetitive monitoring of therapy in the brain, where invasive tissue sampling is contraindicated. We evaluated adeno-associated virus vector expression of a dopamine-2 receptor (D2R) mutant (D2R80A) by positron emission tomography in the brains of mice and cats. D2R80A is inactivated for intracellular signaling and binds subphysiologic amounts of the radioactive [(18)F]-fallypride analog of dopamine. The [(18)F]-fallypride signal bound to D2R80A in the injection site was normalized to the signal from endogenous D2R in the striatum and showed stable levels of expression within individual animals...
2014: Molecular Therapy. Methods & Clinical Development
keyword
keyword
66128
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"