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Canker sore

Hiroto Inoue, Yuto Sato, Shuuhei Shintani, Hiroki Tanabe, Hiromichi Bamba, Yasunobu Komai, Tomoaki Nakamura, Takayuki Imai, Akira Andou
We report the case of a 61-year-old man who experienced severe adverse effects of capecitabine because of dihydropyrimidine dehydrogenase (DPD) deficiency. In 2016, he visited our hospital for adenocarcinoma of the gastroesophageal junction and was prescribed neoadjuvant chemotherapy with capecitabine, cisplatin, and trastuzumab. On day 14 of chemotherapy, he developed severe diarrhea, canker sores, enterocolitis, febrile neutropenia, and thrombocytopenia. He was then urgently hospitalized, and anticancer treatment was stopped...
2018: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
Luca Giannetti, Alberto Murri Dello Diago, Lorenzo Lo Muzio
Recurrent aphtous stomatitis (RAS; recurrent aphtous ulcers, canker sores) is the most common ulcerative disease of the oral mucosa. In this paper we presented the main clinical features, epidemiologic data, etiopathogenetic factors and clinical management, based on the current medical literature reports.
January 11, 2018: Minerva Stomatologica
B Sopeña, J Limeres, L García-Caballero, M Diniz-Freitas, J Seoane, P Diz
We report the case of a 77-year-old male with a history of aortic stenosis and interstitial lung disease, who debuted 3 years ago with an outbreak of necrotic and very painful canker sores. The severity of the lesions and their refractory response to treatment led to several hospital admissions and multiple consultations to different specialists (ENT, rheumatology, dermatology, ophthalmology, cardiology, and internal medicine). During this time, the patient received central parenteral nutrition with an episode of catheter-related septicemia, and he came to require psychiatric assistance for autolytic ideation...
November 11, 2017: Dysphagia
L Y Pang, L P Zou, L L Huang, Y Gao, S F Ma, M N Zhang, Y Y Wang
OBJECTIVE: To assess the efficacy and safety of mammalian target of rapamycin (mTOR) inhibitor rapamycin in treatment of children with cardiac rhabdomyoma, associated with tuberous sclerosis complex (TSC). METHOD: The clinical data of children with cardiac rhabdomyomas, who had received a diagnosis of TSC previously, were collected between September 2011 and November 2015 from Pediatric Department of the People's Liberation Army General Hospital.Patients in line with the inclusion criteria received long-term treatment with sirolimus...
June 2, 2016: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
D Lauritano, M Petruzzi, G M Nardi, F Carinci, G Minervini, D Di Stasio, A Lucchese
Recurrent aphtous stomatitis (aphthae, canker sores) is ones of the most common and painful oral mucosal inflammatory ulcerative conditions; etiopathogenesis is uncertain and only symptomatic therapy is available. We used a dessicating agent based on a concentrated mixture of sulfates. The rationale for use of this product on canker sores is that it cauterises the epithelial tissue affected by the immune response. The aim of this study was to evaluate the topical application of this dessicating agent on aphtous ulcers, and verify its efficacy in reducing pain...
July 2015: Journal of Biological Regulators and Homeostatic Agents
Ayesha Thabusum Dharmavaram, R Sudhakara Reddy, Rajesh Nallakunta
BACKGROUND: Recurrent aphthous ulceration or recurrent aphthous stomatitis is one of the most debilitating and painful oral mucosal disease. This disease entity has no specific cause to occur and no proper laboratory procedures are present to elicit the diagnosis. The treatment options are largely palliative and aimed at reducing symptoms thereby improving patient's oral condition. In the present study the subjects witnessed alleviation of clinical symptoms related to the aphthous ulceration...
March 2015: Journal of Clinical and Diagnostic Research: JCDR
Wawan Sujarwo, Ary Prihardhyanto Keim, Valentina Savo, Paolo Maria Guarrera, Giulia Caneva
ETHNOPHARMACOLOGICAL RELEVANCE: Loloh are herbal drinks produced and consumed exclusively in Bali (Indonesia) to prevent and treat different ailments. This is the first study to document plants species used as Loloh, reporting the phytochemical components and pharmacological properties of the most cited plants. Documenting the plants used in herbal drinks in Bali by local communities to treat various ailments (providing some information on phytochemistry and pharmacology of the most interesting plants)...
July 1, 2015: Journal of Ethnopharmacology
Javier Martínez-González, Luis Téllez Villajos, Marta Aicart-Ramos, Laura Crespo Pérez, Javier Graus Morales, Daniel Boixeda de Miguel, Agustín Albillos Martínez
INTRODUCTION: Obscure gastrointestinal bleeding (OGIB) is defined as bleeding from the gastrointestinal tract with no obvious cause after assessment with upper and lower gastrointestinal endoscopy. In these cases, the source is suspected to be in the small bowel. Obscure bleeding can be occult or overt. The aim of this study was to analyze the clinical and analytical characteristics and findings on capsule endoscopy in patients with OGIB and to determine the factors related to the detection of lesions in both forms of presentation...
February 2015: Gastroenterología y Hepatología
Mai F Tolba, Hany A Omar, Samar S Azab, Amani E Khalifa, Ashraf B Abdel-Naim, Sherif Z Abdel-Rahman
Propolis, a honey bee product, has been used in folk medicine for centuries for the treatment of abscesses, canker sores and for wound healing. Caffeic acid phenethyl ester (CAPE) is one of the most extensively investigated active components of propolis which possess many biological activities, including antibacterial, antiviral, antioxidant, anti-inflammatory, and anti-cancer effects. CAPE is a polyphenolic compound characterized by potent antioxidant and cytoprotective activities and protective effects against ischemia-reperfusion (I/R)-induced injury in multiple tissues such as brain, retina, heart, skeletal muscles, testis, ovaries, intestine, colon, and liver...
October 2, 2016: Critical Reviews in Food Science and Nutrition
Hersheal Aggarwal, Mohit Pal Singh, Prashant Nahar, Hemant Mathur, Sowmya Gv
INTRODUCTION: Apthous ulcers, commonly referred to as canker sores, are the most common ulcerative lesions of the oral mucosa. These are usually painful and are associated with redness, and occasional bleeding from the affected area(s). The aims of treatment are to reduce pain and healing time. AIMS: To assess clinically the efficacy of Low-level laser therapy (LLLT) on recurrent aphthous ulcers for reduction of pain, lesion size, and healing time and to compare the results with those of a sham control group...
February 2014: Journal of Clinical and Diagnostic Research: JCDR
Zuzanna Slebioda, Elżbieta Szponar, Anna Kowalska
Recurrent aphthous stomatitis (RAS; recurrent aphthous ulcers - RAU; canker sores) is a chronic inflammatory, ulcerative condition of the oral mucosa. Its prevalence in the general population ranges between 5% and 20%, depending on the method and group studied. The etiopathogenesis of the disease is considered to be multifactorial, but remains still not fully understood. In patients with RAS, an enhanced immunologic response occurs to some trigger factors that may include: mechanical injury, stress or bacterial and viral antigens...
April 2013: Postȩpy Dermatologii i Alergologii
Zuzanna Slebioda, Elżbieta Szponar, Anna Kowalska
Recurrent aphthous stomatitis (RAS; recurrent aphthous ulcers; canker sores) belongs to the group of chronic, inflammatory, ulcerative diseases of the oral mucosa. Up to now, the etiopathogenesis of this condition remains unclear; it is, however, considered to be multifactorial. The results of currently performed studies indicate that genetically mediated disturbances of the innate and acquired immunity play an important role in the disease development. Factors that modify the immunologic response in RAS include: food allergies, vitamin and microelement deficiencies, hormonal and gastrointestinal disorders (e...
June 2014: Archivum Immunologiae et Therapiae Experimentalis
Justin Bailey, Claire McCarthy, Rita F Smith
Amlexanox appears to be most effective overall. Amlexanox 5% paste reduces ulcer size, pain duration, and healing time.
October 2011: Journal of Family Practice
Karlin T Krebs
Recurrent aphthous ulcers (RAUs), also known as canker sores, aphthous stomatitis, or aphthae, are a very common and often painful condition presenting in primary care. The majority of aphthous ulcers are benign, time-limited (7 to 14 days), and in some cases, require pain management until healed. However, RAUs can be a manifestation of a serious health condition, such as an autoimmune disorder, human immunodeficiency virus, infection, and hematologic or oncologic conditions. Initially, the most important priority in caring for these patients is to obtain a complete history and physical examination to rule out systemic disease and lead to an accurate diagnosis and plan of care...
May 2011: Pediatric Nursing
Jane E Ramberg, Erika D Nelson, Robert A Sinnott
BACKGROUND: A large body of literature suggests that certain polysaccharides affect immune system function. Much of this literature, however, consists of in vitro studies or studies in which polysaccharides were injected. Their immunologic effects following oral administration is less clear. The purpose of this systematic review was to consolidate and evaluate the available data regarding the specific immunologic effects of dietary polysaccharides. METHODS: Studies were identified by conducting PubMed and Google Scholar electronic searches and through reviews of polysaccharide article bibliographies...
2010: Nutrition Journal
Angelina R Sutin, Antonio Terracciano, Luigi Ferrucci, Paul T Costa
This study examines the association between personality traits and bruxism, the repetitive grinding or clenching of teeth. Community-dwelling participants (N = 470) had a comprehensive oral examination by a dentist and completed a dental history and personality questionnaires. Consistent with the literature on state anxiety and depression as antecedents of bruxism, Neuroticism-related traits were associated with self-reported teeth grinding. These traits were also associated with other oral complaints often associated with anxiety (jaw clicks, difficulty chewing food, and dry mouth), but not with more general oral health complaints (unhealthy gums, bleeding gums, and canker sores) or with dentist-assessed occlusal wear or tongue indentations...
June 2010: Journal of Research in Personality
Scott T Kozlak, Stephen J Walsh, Rajesh V Lalla
BACKGROUND: Recurrent aphthous stomatitis (RAS), commonly referred to as canker sores, is a very common and painful oral mucosal disease. Although the etiology of RAS is not well understood, a number of factors may play a role, including nutritional deficiencies. The objective of this study was to compare dietary vitamin intake in RAS patients to that of a control group. METHODS: One hundred subjects, who had suffered at least three episodes of minor RAS in the previous 12 months, completed a detailed Diet History Questionnaire designed and validated by the US National Institutes of Health...
May 2010: Journal of Oral Pathology & Medicine
Jonathan Williams, Thomas Bergmann
OBJECTIVE: This case presentation describes a method of evaluation and a conservative management plan for a child with probable inflammatory bowel disease (Crohn's Disease). Possible causes for this clinical presentation and a brief review of the literature are offered. CLINICAL FEATURES: A 9-year-old female had a history of headaches, stomach ache, foulsmelling soft stools, canker and cold sores, dry skin, stuffy nose with postnasal drip, difficulty concentrating in school, mood swings and growing pains with leg cramps...
2003: Journal of Chiropractic Medicine
A Guinet, G Grateau, C Nifle, A Rozier, F Pico
INTRODUCTION: Few cases of patients with both Familial Mediterranean Fever (FMF) and Multiple Sclerosis (MS) have been reported, mainly from Turkey. Central nervous system manifestations are rare in FMF. CASE REPORT: We report the case of a 37-year-old right-handed man with FMF diagnosed at 17 the age of years and successfully treated with colchicine. The patient was born in Algeria and lived in France since he was four years old. He had a brother who had multiple sclerosis...
November 2008: Revue Neurologique
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No abstract text is available yet for this article.
July 2008: Journal—Oklahoma Dental Association
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