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pills intoxication

Patil Armenian, Alexander Olson, Andres Anaya, Alicia Kurtz, Rawnica Ruegner, Roy R Gerona
In 2013 and 2014, more than 700 deaths were attributed to fentanyl and fentanyl analogues in the United States. Of recent concern is the cluster of unintentional fentanyl overdoses because of tablets thought to be "Norco" purchased on the street in Northern California. U-47700 (trans-3,4-dichloro-N-[2-(dimethyl-amino)cyclohexyl]-N-methylbenz-amide) is a nonfentanyl-based synthetic opioid with 7.5 times the binding affinity of morphine to μ-opioid. We report a case of fentanyl and U-47700 intoxication from what was thought to be illicitly purchased Norco...
July 20, 2016: Annals of Emergency Medicine
Alan K Davis, Harold Rosenberg
This prospective study was designed to test whether the variables proposed by the Theory of Planned Behavior (TPB) were associated with baseline intention to implement and subsequent use of 2 MDMA/ecstasy-specific harm reduction interventions: preloading/postloading and pill testing/pill checking. Using targeted Facebook advertisements, an international sample of 391 recreational ecstasy users were recruited to complete questionnaires assessing their ecstasy consumption history, and their attitudes, subjective norms, perceived behavioral control, habit strength (past strategy use), and intention to use these two strategies...
June 2016: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
İlker Ertuğrul, Emine Polat, Senem Özgür, Vehbi Doğan, Tamer Yoldaş, Şeyma Akşin, Utku Arman Örün, Selmin Karademir
Colchicine, is an old and well-known drug, used for treatment of rheumatic diseases. Nausea, vomiting, abdominal pain, and diarrhea are the clinical symptoms of colchicine poisoning. Cardiotoxicity can lead to mortality. We report a case of colchicine intoxication complicated with complete heart block. A 9-year-old patient ingesting colchicine 0.4-0.5 mg/kg was transferred because of elevation of liver enzymes, and deterioration of kidney functions and cytopenia. History of colchicine ingestion had been unknown at time of admission...
July 2015: Turkish Journal of Pediatrics
Murat Nihat Arslan, Ayşe Özgün, Taner Daş, Durmuş Kumru, Bülent Şam, Sermet Koç
Colchicine is derived from Colchicum autumnale and Gloriosa superba and is used to treat acute gout and familial Mediterranean fever (FMF). Musculoskeletal adverse effects range from myopathy to rhabdomyolysis. An 18-year-old woman, with a 2-year history of FMF treated with colchicine, took 9 colchicine pills (4.5 mg) to relieve severe abdominal pain. On the sixth day of hospitalization, the patient's condition worsened, and she died. As this was a case of fatal poisoning, a forensic autopsy was performed, and the cause of death was determined to be complications of muscle destruction due to colchicine intoxication with the findings of myocytolysis, positive antimyoglobin antibody staining kidney tubules...
June 2016: American Journal of Forensic Medicine and Pathology
Seth C Kalichman, Moira O Kalichman, Charsey Cherry, Ginger Hoyt, Christopher Washington, Tamar Grebler, Brandi Welles, Cindy Merely
BACKGROUND: Drug use poses significant challenges to medical management of HIV infection. Although most research has focused on the influence of intoxication on unintentional adherence to HIV treatment, drug use may also lead to intentional nonadherence, particularly when individuals believe that mixing medications with drugs is harmful. This study examined whether interactive toxicity beliefs predict nonadherence to antiretroviral therapy (ART) over a prospective period of adherence monitoring...
December 15, 2015: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Katrin Sikk, Pille Taba
Methcathinone abuse is a significant cause of parkinsonism among young patients in the Eastern European countries. The drug is synthesized from over-the-counter cold remedies containing ephedrine or pseudoephedrine. The final mixture contains a high concentration of manganese if potassium permanganate is used as the oxidant agent. Though manganese is an essential trace element and its homeostasis is well maintained, exposure to a high level of manganese is neurotoxic. The use of manganese-contaminated methcathinone may cause permanent neurological damage and severe disability...
2015: International Review of Neurobiology
Mohammad Humayun, Iqbal Haider, Aliena Badshah, Fazle Subhan
A 15-year-old boy was referred to the hospital from the periphery with a history of ingestion of 5 wheat pills (aluminium phosphide) 5 days back. He had been given a stomach wash in his village hospital prior to referral. On arrival, he was jaundiced and had developed haematuria too, but otherwise appeared well in himself. Four days after admission, his haemoglobin showed a marked drop and he was shifted to intensive care, keeping in mind the high mortality rate associated with aluminium phosphide intoxication...
April 2015: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Gul Pamukcu Gunaydin, Nurettin Ozgur Dogan, Sevcan Levent, Gulhan Kurtoglu Celik
Supposedly herbal weight loss pills are sold online and are widely used in the world. Some of these products are found to contain sibutramine by FDA and their sale is prohibited. We report a case of a female patient who presented to the emergency department after taking slimming pills. 17-year-old female patient presented to the emergency room with palpitations, dizziness, anxiety, and insomnia. She stated that she had taken 3 pills named La Jiao Shou Shen for slimming purposes during the day. Her vital signs revealed tachycardia...
2015: Case Reports in Emergency Medicine
Jingjing Wei, Limei Yao, Lei Yang, Wei Zhao, Si Shi, Qingyan Cai, Dingsheng Chen, Weirong Li, Qi Wang
ETHNOPHARMACOLOGICAL RELEVANCE: Xingnaojing Injection (XNJI) is a modern Chinese formula came from famous Chinese medicine An Gong Niu Huang Pill. XNJI has been used for treatment of cerebral diseases and stroke in China, and is approved by the State Food and Drug Administration of China for the treatment of acute alcohol intoxication (AAI). XNJI belongs to the ethnopharmacological family of medicines. In this study, we investigated the mechanisms of the XNJI effect on AAI. AIM OF THE STUDY: To investigate the effects of XNJI on glutamate, gamma-aminobutyric acid (GABA) and related receptor in lateral hypothalamic area (LHA) of AAI rat...
May 26, 2015: Journal of Ethnopharmacology
Z Livshits, B A Sampson, M A Howland, R S Hoffman, L S Nelson
CONTEXT: The extent of non-absorbed drug burden in the GI tract following overdose is unknown. Patients who present with clinical signs of toxicity may not undergo decontamination due to assumption that the drug has already been completely absorbed and because of limited scientific evidence of benefit for routine GI decontamination in poisoned patients. OBJECTIVE: The goal of this study was to assess whether people who die of an oral overdose have unabsorbed drug present in the GI tract...
February 2015: Clinical Toxicology
Iain M McIntyre, Catherine E Hamm, James L Sherrard, Ray D Gary, Christopher G Burton, Othon Mena
A 30-year-old man reportedly ingested pills and used illicit drugs with another person. They both fell asleep that night and the following afternoon the other person found him dead. There were used hypodermic needles and a metal spoon with dark tarry substance at the death scene, and two recent puncture sites were found on his body. It was uncertain if he had a history of illicit drug use. Postmortem blood initially screened borderline positive for methamphetamine by ELISA. An alkaline drug screen-detected ethylone which was subsequently confirmed and quantified by a specific GC-MS SIM analysis following solid-phase extraction...
April 2015: Journal of Analytical Toxicology
Jung Hee Wee, Yeon Ho You, Hoon Lim, Wook Jin Choi, Byung Kook Lee, Jeong Ho Park, Kyu Nam Park, Seung Pill Choi
INTRODUCTION: While therapeutic hypothermia (TH) is in clinical use, its efficacy in certain patient groups is unclear. This study was designed to describe the characteristics and outcomes of patients with out-of-hospital cardiac-arrest (OHCA) caused by asphyxia, who were treated with TH. PATIENTS AND METHODS: A multicentre, retrospective, registry-based study was performed using data from the period 2007-2012. Comatose patients who were treated with TH after asphyxial cardiac arrest were included, while those who with cardiac arrest attributed to hanging, drowning or gas intoxication were excluded...
April 2015: Resuscitation
J Arditti, J H Bourdon, M Spadari, L de Haro, N Richard, M Valli
Dietary supplements containing Ma Huang (chinease ephedra) are available on the web sites and dietary shops in USA. They are widely promoted and used as a mean of weight reduction and energy enhancement. They contain Ma Huang alone or combined with Guarana (caffeine), creatine, St Jonh's wort, carnitine and are proposed with different labels. Numerous reports of adverse reactions and acute intoxication related to these products use were described in the medical literature. In the light of the severity of these cases, some of which resulted in permanent injury and death, the Food and Drug Administration has proposed limits on the dose and duration of use of such supplements...
2002: Acta Clinica Belgica
Enrico Gerace, Michele Petrarulo, Fabrizio Bison, Alberto Salomone, Marco Vincenti
The distribution of mephedrone in the body fluids and tissues of a subject found dead after the concomitant intake of cocaine and mephedrone is reported. Mephedrone (4-methylmethcathinone) is a designer drug of the phenethylamine family that is able to cause central nervous system stimulation, psychoactivity and hallucinations and that is becoming popular among youth as a recreational drug. Mephedrone has been available in Europe since 2007, and it is sold through the internet and by local shops as bath salt or plant food...
October 2014: Forensic Science International
Jenica D Tapocik, Estelle Barbier, Meghan Flanigan, Matthew Solomon, Alexandra Pincus, Andrew Pilling, Hui Sun, Jesse R Schank, Courtney King, Markus Heilig
Escalation of voluntary alcohol consumption is a hallmark of alcoholism, but its neural substrates remain unknown. In rats, escalation occurs following prolonged exposure to cycles of alcohol intoxication, and is associated with persistent, wide-ranging changes in gene expression within the medial prefrontal cortex (mPFC). Here, we examined whether induction of microRNA (miR) 206 in mPFC contributes to escalated alcohol consumption. Following up on a microarray screen, quantitative real-time reverse transcription PCR (qPCR) confirmed that a history of dependence results in persistent (>3weeks) up-regulation of miR-206 expression in the mPFC, but not in the ventral tegmental area, amygdala, or nucleus accumbens...
March 26, 2014: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Li Liu, Shu-fei Wang, Rui Xu, Xiao-ming Peng
OBJECTIVE: To observe the effects of Guipi Pill (GPP) on bone marrow cell cycle of mice exposed to benzene and to explore its possible mechanisms for regulating hematopoiesis. METHODS: Seventy-two Kunming mice were randomly divided into 6 groups, i.e., the normal control group, the model group, the Western medicine treatment group, the large, middle, and small dose GPP groups, 12 in each group. The mice were exposed to manually simulated high concentrations of benzene fqr eight h every day, fourteen successive days, to replicate benzene intoxication model...
March 2013: Chinese Journal of Integrated Traditional and Western Medicine
Márcia Sá Monteiro, Maria de Lourdes Bastos, Paula Guedes de Pinho, Márcia Carvalho
N-benzylpiperazine (BZP) has become popular among recreational drug users as the major active ingredient of "party pills" due to its stimulant and euphoric properties. Before BZP legal restrictions, these pills were sold as a safe and legal alternative to classical amphetamines like ecstasy. New Zealand, given the size of its legal market prior to BZP control, is the country that most contributed to the knowledge about the patterns of use, motivations and positive and adverse effects resulting from its consumption, though the interest in BZP-party pills was observed all over the world...
June 2013: Archives of Toxicology
Jan Magdalan, Marcin Zawadzki, Tomasz Słoka, Tomasz Sozański
The paper presents a case of fatal intoxication after massive sustained-release clomipramine overdosage with prolonged toxicity related to a large gastric pharmacobezoar. 42-year-old female was admitted to the toxicology unit 14 h after drugs ingestion. At admission patient was deeply unconscious, required controlled mechanical ventilation. Serum total level of TCAs was 1955 ng/mL. Gastric lavage revealed no pills. Within the next 12h the patient's clinical condition improved. TCAs level decreased to 999 ng/mL...
June 10, 2013: Forensic Science International
Andreas Schaper, Alessandro Ceschi, Michael Deters, Guido Kaiser
The organization and work of a poisons center are demonstrated on the basis of GIZ-Nord Poisons Center Annual Report for 2011. In a short summary the basic principles of clinical toxicology are elucidated: the indications for gastric lavage and the application of activated charcoal. Moreover the means of enhanced elimination are presented: hemodialysis, hemoperfusion, multi-dose activated charcoal and molecular absorbent recirculating system (MARS). Gastric lavage is indicated within one hour after ingestion of a life-threatening dose of a poison...
March 2013: European Journal of Internal Medicine
Paula Proença, João Miguel Franco, Carla Mustra, Carla Monteiro, Joana Costa, Francisco Corte-Real, Duarte Nuno Vieira
Trends in forensic toxicology show the introduction of rapid analytical methods for the simultaneous quantitative analysis of drugs. The authors present a fatal case involving a 32-year-old male, found dead in bed by his mother, with several blue, white and orange pills next to the body. Empty tablets were found in the trash bin and a suicide note was on the desk. He was diagnosed with bipolar disorder and had been under psychiatric treatment, having repeatedly demonstrated intent to commit suicide. A rapid method was developed to determine 55 different medicines and 32 benzodiazepines in blood by ultra-performance liquid chromatography (UPLC) coupled with tandem mass spectrometry (MS/MS) with electrospray ionization source in positive and negative ion mode...
April 10, 2013: Forensic Science International
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