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Carcinoma endometrium

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https://www.readbyqxmd.com/read/29140883/mage-a4-and-mage-a1-immunohistochemical-expression-in-high-grade-endometrial-cancer
#1
Sanja Srdelić, Ivana Kuzmić-Prusac, Giulio C Spagnoli, Antonio Juretić, Vesna Čapkun
The aim was to investigate MAGE-A4 and MAGE-A1 protein expression in high-grade endometrial cancer and determine its correlation with histologic subtype, FIGO stage, presence of vascular invasion, disease free, and overall survival. Immunohistochemical staining was performed by using 77B (MAGE-A1) and 57B (MAGE-A4) monoclonal antibodies on paraffin-embedded sections from high-grade endometrial cancers diagnosed in University Hospital Split between 1998 and 2011 (n=77). Median follow-up time for survivors was 48 mo...
November 14, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/29137657/p53-aberrations-in-low-grade-endometrioid-carcinoma-of-the-endometrium-with-nodal-metastases-possible-insights-on-pathogenesis-discerned-from-immunohistochemistry
#2
Oluwole Fadare, Vinita Parkash
BACKGROUND: TP53 mutations are rarely identified in low grade endometrioid carcinoma of the endometrium, and their pathogenic significance in such tumors is evidenced by the fact that TP53 aberrations have been associated with reduced recurrence-free survival in this subset of tumors. However, TP53 aberrations may not always represent a driving molecular event in a given endometrial cancer with a mutation. In this case study, the immunophenotype of a distinctive low grade endometrioid adenocarcinoma with an unusual pattern of lymph node metastases is used to explore the possible roles for underlying TP53-related molecular events in its pathogenesis...
November 14, 2017: Diagnostic Pathology
https://www.readbyqxmd.com/read/29119739/fertility-outcomes-in-infertile-women-with-complex-hyperplasia-or-complex-atypical-hyperplasia-who-received-progestin-therapy-and-in-vitro-fertilization
#3
Miao Li, Jia-Lun Song, Ying Zhao, She-Ling Wu, Hong-Bin Liu, Rong Tang, Lei Yan
This study aimed to evaluate fertility and oncologic outcomes in women with complex hyperplasia (CH) or complex atypical hyperplasia (CAH) who received fertility-sparing therapy and in vitro fertilization (IVF). Endometrial carcinoma is the most common carcinoma of the female genital tract, and is associated with endometrial hyperplasia (EH) resulting from long-term unopposed estrogenic stimulation of the endometrium. EH is characterized by non-physiological proliferation of endometrium that results in glands with irregular shapes and varying sizes...
2017: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/29106744/germ-cell-tumor-growth-patterns-originating-from-clear-cell-carcinomas-of-the-ovary-and-endometrium-a-comparative-immunohistochemical-study-favouring-their-origin-from-somatic-stem-cells
#4
F F Nogales, J Prat, M Schuldt, N Cruz-Viruel, B Kau, E D'Angelo, X Matias-Guiu, A Vidal, W G McCluggage, J W Oosterhuis
AIMS: To report a series of 11 ovarian and one endometrial neoplasm in elderly patients with mixed clear cell tumour and germ cell tumour (GCT) components, to compare their immunohistochemical and demonstrate a putative stem cell population. METHODS AND RESULTS: The clear cell tumours included 11 clear cell carcinomas (CCC) and 1 borderline clear cell tumour, while the GCT always included glandular yolk sac tumour (YST). In 4 cases, there were also foci of teratoma with immature neuroepithelial and endodermal tissues, and undifferentiated areas showing true embryoids...
November 6, 2017: Histopathology
https://www.readbyqxmd.com/read/29072180/clinicopathologic-and-survival-results-in-serous-endometrium-carcinoma-and-subgroup-analysis-for-mixed-serous-and-pure-serous-histology
#5
Alpaslan Kaban, Samet Topuz, Hamdullah Sözen, Yağmur Minareci, Yavuz Salihoğlu
OBJECTIVE: To review theclinicopathologic and survival outcomes of the patients with serous endometrial cancer (EC) andto investigate subgroup analysis based on pure serous and mixed serous EC subtypes Material and Methods: Patients who had undergone EC surgery between 2002 and 2014 and who were reported as serous EC were enrolled in the study. All patients were diagnosed with serous endometrial cancer or mixed serous endometrial cancer with serous component higher than 10% based on the postoperative pathology report Results: A total of 93 patients were analyzed...
October 26, 2017: Journal of the Turkish German Gynecological Association
https://www.readbyqxmd.com/read/29020787/-carcinosarcoma-of-the-endometrium-with-melanocytic-differentiation-case-report
#6
D Berezovskiy, P Vlasák, J Kosťun, J Bouda, J Presl
OBJECTIVE: The case report presents a case of 60-year old woman with a rare malignant mixed Müllerian tumor with melanomatous differentiation diagnosed from a histology after cervical polyp ablation and curettage. DESIGN: Case report. SETTING: Department of gynecology and obstetrics, University Hospital in Pilsen. CONCLUSION: Carcinosarcoma, previously malignant mixed Müllerian tumor, is a very rare aggressive endometrial carcinoma with low incidence, which typically occurs among older women and commonly affects the uterine body and cervix...
2017: Ceská Gynekologie
https://www.readbyqxmd.com/read/29019325/ambiguity-of-whole-body-pet-ct-scans-in-diagnosis-of-co-existing-tuberculosis-and-malignancy-is-histopathological-confirmation-mandatory
#7
Prekshi Chaudhary, Sweety Gupta, Nitin Leekha, Ravi S Rajendra, Shiv S Mishra, Vandana Arora, Sudarsan De, Sandeep Agarwal
INTRODUCTION: Whole body PET CT is an important investigation tool in malignancy patients and helps in ascertaining the metabolic activity and exact stage of the disease. However, like any other investigation, false positive results do exist and certain diseases other than cancer may show increased uptake. Hence, a careful evaluation of PET CT and clinical correlation in malignancy patients is a must to accomplish the suitable treatment. METHODS: In this retrospective observational study, seven cases of cancer with concomitant tuberculosis were included...
September 2017: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/28984674/targeted-genomic-profiling-reveals-recurrent-kras-mutations-in-mesonephric-like-adenocarcinomas-of-the-female-genital-tract
#8
Jelena Mirkovic, Marie McFarland, Elizabeth Garcia, Lynette M Sholl, Neal Lindeman, Laura MacConaill, Fei Dong, Michelle Hirsch, Marisa R Nucci, Charles M Quick, Christopher P Crum, W Glenn McCluggage, Brooke E Howitt
Mesonephric adenocarcinoma most commonly arises in the cervix and is presumed to be derived from normal or hyperplastic mesonephric remnants. It is characterized by recurrent KRAS mutations and lack of PIK3CA/PTEN alterations. Adenocarcinomas of the uterine corpus and ovary characterized by morphologic and immunophenotypic similarities to mesonephric adenocarcinoma have been reported. The pathogenesis of these tumors, which have been designated "mesonephric-like adenocarcinomas" is unknown, and it has been debated whether these represent mesonephric adenocarcinomas that arise in the endometrium/ovary or endometrioid adenocarcinomas that closely mimic mesonephric adenocarcinoma...
October 3, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28984400/mutation-analysis-by-whole-exome-sequencing-of-endometrial-hyperplasia-and-carcinoma-in-one-patient-abnormalities-of-polymerase-epsilon-and-the-phosphatidylinositol-3-kinase-pathway
#9
Tsutomu Miyamoto, Hirofumi Ando, Ryoichi Asaka, Yasushi Yamada, Tanri Shiozawa
In order to understand the role of gene mutations in endometrial carcinogenesis, whole exome sequencing via laser microdissection was performed in the normal endometrium, atypical endometrial hyperplasia and endometrial carcinoma in the same patient. A total of 4046 and 5746 mutations with amino acid substitution were detected in endometrial hyperplasia and endometrial carcinoma, respectively; 2252 were common in both tissues and might play crucial roles in early carcinogenesis. These common mutations included polymerase epsilon (POLE) and DNA mismatch repair (MMR) genes, indicating that an ultra-mutated phenotype, and also included PTEN and PIK3CA...
October 6, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28969146/primary-endometrial-squamous-cell-carcinoma-in-situ-with-extensive-icthyosis-uteri-a-rare-case-report
#10
Manjula Jain, Anamika Kashyap, Ratna Biswas
Primary squamous cell carcinoma of the endometrium is a rare entity with primary endometrial squamous cell carcinoma in-situ being more uncommon. We report a 60-year-old multiparous post-menopausal woman who presented with a lower abdominal swelling alongwith difficulty in urination for five months. Total abdominal hysterectomy with bilateral salpingo-oophorectomy showed an enlarged uterus with pyometra. A diagnosis of primary squamous cell carcinoma in-situ of the endometrium was made on histopathology.
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28967955/intraoperative-pathologic-consultation-on-hysterectomy-specimens-for-endometrial-cancer-an-assessment-of-the-accuracy-of-frozen-sections-gross-only-evaluations-and-obtaining-random-sections-of-a-grossly-normal-endometrium
#11
MULTICENTER STUDY
Mohamed Mokhtar Desouki, Zaibo Li, Omar Hameed, Oluwole Fadare
Objectives: Pathologic intraoperative consultation (IOC) is a common approach for segregating the subset of patients with endometrial cancer who likely require a lymphadenectomy. Methods: We evaluate factors related to the performance and value of IOC, including the accuracy of frozen sections, "gross-only examinations," and obtaining random sections when a gross lesion is not apparent. Results: IOC was performed by gross examination only in 17 (8%) of 250 cases, the specificity and negative predictive value of which in diagnosing cancer were 100% and 85%, respectively...
October 1, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28965628/cyclin-d1-is-significantly-associated-with-stage-of-tumor-and-predicts-poor-survival-in-endometrial-carcinoma-patients
#12
Mohamad Nidal Khabaz, Amer Shafie Abdelrahman, Nadeem Shafique Butt, Basim Al-Maghrabi, Jaudah Al-Maghrabi
Cyclin D1 overexpression has been described to have oncogenic role and association with diagnosis, prognosis and survival in various tumors. This study will describe the immunohistochemical phenotype of cyclin D1, and investigate the correlation between these patterns of expression and clinicopathological parameters of endometrial carcinomas, to conclude the clinical relevance of cyclin D1 expression in the evolution of endometrial neoplasms. This study employed 101 endometrial tissue samples which include 71 endometrial carcinomas and thirty normal and benign endometrium cases...
October 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/28951854/ospemifene-a-novel-option-for-the-treatment-of-vulvovaginal-atrophy
#13
REVIEW
Jae Jun Shin, Seul Ki Kim, Jung Ryeol Lee, Chang Suk Suh
Ospemifene-a third-generation selective estrogen receptor modulator approved by the Food and Drug Administration in 2013-is an oral medication for the treatment of dyspareunia. In postmenopausal women with vulvovaginal atrophy, ospemifene significantly improves the structure and pH levels of the vagina, reducing dyspareunia. It is available as a 60-mg tablet; hence, women who may have had prior difficulty with vaginal administration or on-demand use of nonprescription lubricants and moisturizers would likely prefer this form of treatment...
August 2017: Journal of Menopausal Medicine
https://www.readbyqxmd.com/read/28945214/clear-cell-carcinoma-of-the-endometrium-evaluation-of-prognostic-parameters-in-a-multi-institutional-cohort-of-165-cases
#14
Eman Abdulfatah, Sharif Sakr, Sumi Thomas, Zaid Al-Wahab, David G Mutch, Sean Dowdy, Sudeshna Bandyopadhyay, Adnan Munkarah, Mohamed Elshaikh, Robert Morris, Rouba Ali-Fehmi
OBJECTIVES: Clear cell carcinoma (CCC) comprises a rare yet an aggressive subtype, accounting for less than 5% of all uterine carcinomas. Several clinicopathologic features have been predictive of poor prognosis; however, data remain controversial. The aim of this study was to evaluate the clinicopathologic features of a multi-institutional cohort of endometrial CCC in order to identify which, if any, have prognostic significance. METHODS: Retrospective review of endometrial CCC diagnosed between 1995 and 2012 at 3 institutions was conducted to evaluate clinicopathologic parameters: age, race, tumor size, stage, myometrial invasion (MI), lymphovascular invasion, lymph node and adnexal involvement, adjuvant therapy, and outcomes...
October 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28936889/t2-relaxometry-mapping-in-demonstrating-layered-uterine-architecture-parameter-optimization-and-utility-in-endometrial-carcinoma-and-adenomyosis-a-feasibility-study
#15
Adarsh Ghosh, Tulika Singh, Rashmi Bagga, Radhika Srinivasan, Veenu Singla, Niranjan Khandelwal
OBJECTIVE: We evaluate the feasibility of T2 relaxometry mapping of the uterus and demonstrate its diagnostic utility in endometrial carcinoma and adenomyosis and discuss the optimum imaging parameters as used in our institute. METHODS: Institute review board approval was obtained and multispin echo (MSE) imaging of the pelvis was done with variable time to echo in three patients, two with endometrial carcinoma and one with adenomyosis. T2 parametric maps and curves were plotted and the T2 times of the diseased endometrium, superficial and deep myometrium were established...
October 27, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28888417/american-brachytherapy-society-recurrent-carcinoma-of-the-endometrium-task-force-patterns-of-care-and-review-of-the-literature
#16
Mitchell Kamrava, Sushil Beriwal, Beth Erickson, David Gaffney, Anuja Jhingran, Ann Klopp, Sang June Park, Akila Viswanathan, Catheryn Yashar, Lilie Lin
PURPOSE: The purpose of this American Brachytherapy Society task force is to present a literature review and patterns of care by a panel of experts for the management of vaginal recurrence of endometrial cancer. METHODS AND MATERIALS: In 2016, the American Brachytherapy Society Board selected a panel of experts in gynecologic brachytherapy to update our current state of knowledge for managing vaginal recurrence of endometrial cancer. Practice patterns were evaluated via an online survey and clinical updates occurred through a combination of literature review and clinical experience and/or expertise...
September 6, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28836043/expression-of-neurotensin-receptor-1-in-endometrial-adenocarcinoma-is-correlated-with-histological-grade-and-clinical-outcome
#17
Mikaël Agopiantz, Patricia Forgez, Jean-Matthieu Casse, Stéphanie Lacomme, Claire Charra-Brunaud, Isabelle Clerc-Urmès, Olivier Morel, Céline Bonnet, Jean-Louis Guéant, Jean-Michel Vignaud, Anne Gompel, Guillaume Gauchotte
The promalignant effects of neurotensin (NTS) are sustained in many solid tumors, including hormone-dependent cancers. As the endometrium is also subjected to hormonal regulation, we evaluated the contribution of NTS to endometrial carcinogenesis. Neurotensin receptor 1 (NTSR1) expression and NTSR1 promoter methylation (HM450) were analyzed in 385 cases of endometrial carcinoma from The Cancer Genome Atlas (TCGA). Additionally, from a series of 100 endometrial carcinomas, and 66 benign endometrium samples, NTS and NTSR1 labeling was evaluated by immunohistochemistry...
October 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28797999/long-term-results-of-post-operative-pelvic-image-guided-intensity-modulated-radiotherapy-in-gynecological-malignancies
#18
Rashi Agrawal, Sowmiya Prithiviraj, Dinesh Singh, Vaishali Zamre, Sandeep Agrawal, Arun Kumar Goel, Kanika Gupta, Bala Subramanian
OBJECTIVE: To assess late clinical outcomes with image guided intensity modulated radiotherapy (IG- IMRT) in gynecological malignancies. PATIENTS AND METHODS: We have been practicing IG IMRT for gynecological malignancies since January 2009. Here we are presenting our experience with this modern technique at median follow up of 38 months. During whole treatment bladder filling protocol was followed. Both target volumes and critical structures were contoured according to RTOG guidelines...
May 2017: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/28796747/morphologic-and-immunohistochemical-study-of-clear-cell-carcinoma-of-the-uterine-endometrium-and-cervix-in-comparison-to-ovarian-clear-cell-carcinoma
#19
Baohui Ju, Jianmei Wang, Bo Yang, Lin Sun, Yuhong Guo, Quan Hao, Jianghua Wu
Endometrial clear cell carcinoma (ECCC) and clear cell adenocarcinoma of the cervix (CCAC) are uncommon gynecologic cancers that have morphologic and phenotypic features similar to ovarian clear cell carcinoma (OCCC), but the 3 entities may not be completely identical. This study identified the morphologic and phenotypic characteristics and the differences between ECCC and CCAC in Comparison to OCCC. The morphologic features of 16 ECCCs, 7 CCACs, and 22 OCCCs are described. The immunoprofiles of hepatocyte nuclear factor (HNF) 1β, napsin A, estrogen, progesterone, p53, and Ki-67 were assessed...
August 7, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28764184/ichthyosis-uteri-associated-with-endometrial-adenocarcinoma-a-case-report
#20
Nishu Bhardwaj, Preeti Diwaker, Priyanka Gogoi, Neelam Wadhwa, Kiran Mishra
The replacement of the entire or extensive parts of endometrial lining by stratified squamous epithelium is a rare entity known as ichthyosis uteri. It is considered to be a benign condition but may be associated with dysplastic changes and primary squamous cell carcinoma of the endometrium. Its association with endometrial adenocarcinoma is very rare. The aetiology of this condition is not clearly understood till date. We report a case of ichthyosis uteri associated with endometrial adenocarcinoma in a 70-year-old female who presented with complaint of per-vaginal bleeding for six months and underwent hysterectomy after being diagnosed with endometrial carcinoma...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
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