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https://www.readbyqxmd.com/read/29205667/the-effect-of-postnatal-manganese-exposure-on-the-nmda-receptor-signaling-pathway-in-rat-hippocampus
#1
Lei Wang, HuanHuan Fu, Bin Liu, XiaoYan Liu, WeiWei Chen, XiaoDan Yu
Overexposure to manganese (Mn) is associated with neurological disorders in children. Evidence indicated that N-methyl-d-aspartate (NMDA) receptor signaling pathway was critical for neurobehavioral function. However, whether NMDA receptor signaling pathway contributes to Mn-induced neurotoxicity remains unknown. In this study, newborn Sprague-Dawley rats were randomly assigned to four groups exposed to 0, 10, 20, and 30 mg/kg of Mn2+ by intraperitoneal injection (n = 10/group: five males and five females)...
December 4, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/29205171/engineered-core-shell-magnetic-nanoparticle-for-mr-dual-modal-tracking-and-safe-magnetic-manipulation-of-ependymal-cells-in-live-rodents
#2
Yung-Kang Peng, Cathy N P Lui, Yu-Wei Chen, Shang-Wei Chou, Pi-Tai Chou, Ken K L Yung, S C Edman Tsang
Tagging recognition group(s) on superparamagnetic iron oxide is known to aid localisation (imaging), stimulation and separation of biological entities using magnetic resonance imaging (MRI) and magnetic agitation/separation (MAS) techniques. Despite the wide applicability of iron oxide nanoparticles in T 2-weighted MRI and MAS, the quality of the images and safe manipulation of the exceptionally delicate neural cells in a live brain are currently the key challenges. Here, we demonstrate the engineered manganese oxide clusters-iron oxide core-shell nanoparticle as an MR dual-modal contrast agent for neural stem cells (NSCs) imaging and magnetic manipulation in live rodents...
December 5, 2017: Nanotechnology
https://www.readbyqxmd.com/read/29193611/effect-of-the-cross-talk-between-autophagy-and-endoplasmic-reticulum-stress-on-mn-induced-alpha-synuclein-oligomerization
#3
Chang Liu, Dong-Ying Yan, Xuan Tan, Zhuo Ma, Can Wang, Yu Deng, Wei Liu, Tian-Yao Yang, Zhao-Fa Xu, Bin Xu
Overexposure to manganese (Mn) has been known to induce alpha-synuclein (α-Syn) oligomerization, which is degraded mainly depending on endoplasmic reticulum stress (ER stress) and autophagy pathways. However, little data reported the cross-talk between ER stress and autophagy on Mn-induced α-Syn oligomerization. To explore the relationship between ER stress and autophagy, we used 4-phenylbutyric acid (4-PBA, the ER stress inhibitor), rapamycin (Rap, autophagy activator) and 3-methyladenine (3-MA, autophagy inhibitor) in mice model of manganism...
November 29, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/29187042/effect-of-discontinuation-of-manganese-supplementation-from-home-parenteral-nutrition-solutions-on-whole-blood-levels-and-magnetic-resonance-imaging-of-the-brain-a-5-year-cohort-study
#4
Jennifer Jin, Olivia Saqui, Johane P Allard
BACKGROUND: Manganese (Mn) is included in current premixed multiple trace element (TE) additives for home parenteral nutrition (HPN). However, there is a risk of oversupplementation of Mn due to contamination from PN additives. Oversupplementation can produce Mn toxicity with neurologic symptoms and abnormalities on brain magnetic resonance imaging (MRI). In 2009, we reported that whole-blood Mn levels were above the upper limit of normal in 16 HPN patients, with 81% having MRI findings...
March 1, 2017: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29181695/memri-reveals-altered-activity-in-brain-regions-associated-with-anxiety-locomotion-and-cardiovascular-reactivity-on-the-elevated-plus-maze-in-the-wky-vs-shr-rats
#5
Jasenka Zubcevic, Jacqueline Watkins, Pablo D Perez, Luis M Colon-Perez, Maureen T Long, Marcelo Febo, Linda Hayward
Individuals with anxiety/depression often have exaggerated cardiovascular responses to stressful stimuli and a comorbidity with hypertension. Alternatively, individuals with hypertension can be more anxious. In the present study cardiovascular changes were evaluated during behavioral testing of anxious behavior on the elevated plus maze (EPM) in the spontaneously hypertensive rat (SHR), a rodent model of neurogenic hypertension, and compared to the response of the more anxious, but normotensive, Wistar-Kyoto rat (WKY)...
November 27, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29126931/phytochemical-allylguaiacol-exerts-a-neuroprotective-effect-on-hippocampal-cells-and-ameliorates-scopolamine-induced-memory-impairment-in-mice
#6
Hye-Sun Lim, Bu-Yeo Kim, Yu Jin Kim, Soo-Jin Jeong
Allylguaiacol is a phytochemical occurring in various plants such as cloves, cinnamon, basil, and nutmeg. Pharmacological effects of allylguaiacol include antimicrobial, anti-inflammatory, anticancer, antioxidant, and neuroprotective activity. Although allylguaiacol is considered to have neuroprotective effects, there is no report on its regulatory mechanisms at the molecular level. In the present study, we investigated the mechanisms of allylguaiacol as an antioxidant and neuroprotective agent using hydrogen peroxide (H2O2)-treated HT22 hippocampal cells...
November 7, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29118417/brain-activation-induced-by-chronic-psychosocial-stress-in-mice
#7
Mikaela A Laine, Ewa Sokolowska, Mateusz Dudek, Saija-Anita Callan, Petri Hyytiä, Iiris Hovatta
Chronic psychosocial stress is a well-established risk factor for neuropsychiatric diseases. Abnormalities in brain activity have been demonstrated in patients with stress-related disorders. Global brain activation patterns during chronic stress exposure are less well understood but may have strong modifying effects on specific brain circuits and thereby influence development of stress-related pathologies. We determined neural activation induced by chronic social defeat stress, a mouse model of psychosocial stress...
November 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29101783/one-pot-preparation-of-hydrophilic-manganese-oxide-nanoparticles-as-t1-nano-contrast-agent-for-molecular-magnetic-resonance-imaging-of-renal-carcinoma-in-vitro-and-in-vivo
#8
Jingjing Li, Chen Wu, Pingfu Hou, Min Zhang, Kai Xu
Magnetic resonance imaging (MRI) contrast agents have become a necessary part for clinical practice to improve the sensitivity for the diagnosis of small lesions and injuries. Among them, manganese oxide nanoparticle (MnO NPs)-based MRI contrast agent attracts more and more attention because of their better performance in the detection of brain disease and positive enhancement in T1-weighted image. However, the relatively low r1 relaxivity and complex synthetic route hampered their wider applications. In this work, we proposed a one-pot approach to prepare hydrophilic MnO NPs via a polyol-like method with poly (ethylene glycol) (PEG) as both a solvent and surfactant...
October 27, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29096311/manganese-accumulates-in-the-brain-of-northern-quolls-dasyurus-hallucatus-living-near-an-active-mine
#9
Ami Fadhillah Amir Abdul Nasir, Skye F Cameron, Frank A von Hippel, John Postlethwait, Amanda C Niehaus, Simon Blomberg, Robbie S Wilson
Mining is fundamental to the Australian economy, yet little is known about how potential contaminants bioaccumulate and affect wildlife living near active mining sites. Here, we show using air sampling that fine manganese dust within the respirable size range is found at levels exceeding international recommendations even 20 km from manganese extraction, processing, and storage facilities on Groote Eylandt, Northern Territory. Endangered northern quolls (Dasyurus hallucatus) living near mining sites were found to have elevated manganese concentrations within their hair, testes, and in two brain regions-the neocortex and cerebellum, which are responsible for sensory perception and motor function, respectively...
October 28, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29083995/engineered-core-shell-magnetic-nanoparticle-for-mr-dual-modal-tracking-and-safe-magnetic-manipulation-of-ependymal-cells-in-live-rodent
#10
Peng Yung-Kang, Cathy N P Lui, Yu-Wei Chen, Shang-Wei Chou, Chou Pi-Tai, Ken K L Yung, Edman Chi Tsang
Tagging recognition group(s) on superparamagnetic iron oxide is known to aid localization (imaging), stimulation and separation of biological entities using magnetic resonance imaging (MRI) and magnetic agitation/separation (MAS) techniques. Despite the wide applicability of iron oxide nanoparticle in T2-weighted MRI and MAS, the quality of image and safe manipulation of exceptionally delicate neural cells in a live brain are currently the key challenges. Here, we demonstrate the engineered manganese oxide clusters-iron oxide core-shell nanoparticle as a MR dual-modal contrast agent (DMCA) for the applications in neural stem cells imaging and magnetic manipulation in live rodent...
October 30, 2017: Nanotechnology
https://www.readbyqxmd.com/read/29071558/the-relation-between-brain-mri-findings-and-blood-manganese-levels-in-renal-transplantation-hemodialysis-and-peritoneal-dialysis-patients
#11
Esra Akcan, Sultan Özkurt, Garip Sahin, Ahmet Ugur Yalcin, Baki Adapinar
PURPOSE: Various factors can affect blood and tissue levels of trace elements in patients with end-stage renal disease. There are a few studies showing hyperintensity of basal ganglia associated with manganese deposition in hemodialysis (HD) patients. The present study aimed to investigate the intensity changes as markers of manganese deposition in the basal ganglia and to demonstrate their association with blood manganese levels using ICP/MS technique in HD, peritoneal dialysis (PD), and renal transplant patients...
October 25, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/29070548/excess-iron-considerations-related-to-development-and-early-growth
#12
REVIEW
Marianne Wessling-Resnick
What effects might arise from early life exposures to high iron? This review considers the specific effects of high iron on the brain, stem cells, and the process of erythropoiesis and identifies gaps in our knowledge of what molecular damage may be incurred by oxidative stress that is imparted by high iron status in early life. Specific areas to enhance research on this topic include the following: longitudinal behavioral studies of children to test associations between iron exposures and mood, emotion, cognition, and memory; animal studies to determine epigenetic changes that reprogram brain development and metabolic changes in early life that could be followed through the life course; and the establishment of human epigenetic markers of iron exposures and oxidative stress that could be monitored for early origins of adult chronic diseases...
December 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29070527/extracellular-vesicles-released-by-cardiomyocytes-in-a-doxorubicin-induced-cardiac-injury-mouse-model-contain-protein-biomarkers-of-early-cardiac-injury
#13
Chontida Yarana, Dustin Carroll, Jing Chen, Luksana Chaiswing, Yanming Zhao, Teresa Noel, Michael Alstott, Younsoo Bae, Emily V Dressler, Jeffrey A Moscow, D Allan Butterfield, Haining Zhu, Daret K St Clair
PURPOSE: Cardiac injury is a major cause of death in cancer survivors, and biomarkers for it are detectable only after tissue injury has occurred. Extracellular vesicles (EVs) remove toxic biomolecules from tissues and can be detected in the blood. Here, we evaluate the potential of using circulating EVs as early diagnostic markers for long-term cardiac injury. EXPERIMENTAL DESIGN: Using a mouse model of doxorubicin (DOX)-induced cardiac injury, we quantified serum EVs, analyzed proteomes, measured oxidized protein levels in serum EVs released after DOX treatment, and investigated the alteration of EV content...
October 25, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29068792/neurodevelopmental-and-neurological-effects-of-chemicals-associated-with-unconventional-oil-and-natural-gas-operations-and-their-potential-effects-on-infants-and-children
#14
REVIEW
Ellen Webb, Julie Moon, Larysa Dyrszka, Brian Rodriguez, Caroline Cox, Heather Patisaul, Sheila Bushkin, Eric London
Heavy metals (arsenic and manganese), particulate matter (PM), benzene, toluene, ethylbenzene, xylenes (BTEX), polycyclic aromatic hydrocarbons (PAHs) and endocrine disrupting chemicals (EDCs) have been linked to significant neurodevelopmental health problems in infants, children and young adults. These substances are widely used in, or become byproducts of unconventional oil and natural gas (UOG) development and operations. Every stage of the UOG lifecycle, from well construction to extraction, operations, transportation and distribution can lead to air and water contamination...
October 25, 2017: Reviews on Environmental Health
https://www.readbyqxmd.com/read/29050909/bold-fmri-in-the-mouse-auditory-pathway
#15
Guilherme Blazquez Freches, Cristina Chavarrias, Noam Shemesh
The auditory pathway is widely distributed throughout the brain, and is perhaps one of the most interesting networks in the context of neuroplasticity. Accurate mapping of neural activity in the entire pathway, preferably noninvasively, and with high resolution, could be instrumental for understanding such longitudinal processes. Functional magnetic resonance imaging (fMRI) has clear advantages for such characterizations, as it is noninvasive, provides relatively high spatial resolution and lends itself for repetitive studies, albeit relying on an indirect neurovascular coupling to deliver its information...
October 16, 2017: NeuroImage
https://www.readbyqxmd.com/read/29032009/potential-for-stem-cell-treatment-in-manganism
#16
Thatiane C de Moura, Szeifoul Afadlal, Alan S Hazell
Development of manganism (also known as manganese neurotoxicity) is a major complication of manganese exposure in which neurological dysfunction is linked to accumulation of the metal in brain. Due to neuronal cell death in basal ganglia structures, particularly the globus pallidus, functional recovery is limited. Bearing a resemblance to Parkinson's disease, effective treatment for manganism is currently limited. However, the rapidly developing field of stem cell research offers new hope for the treatment of illnesses in which neurodegeneration is a major feature...
October 11, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/29030019/in-situ-different-antioxidative-systems-contribute-to-the-site-specific-methylmercury-neurotoxicity-in-mice
#17
Masatake Fujimura, Fusako Usuki
Methylmercury (MeHg), an environmental toxicant, induces site-specific neurotoxicity in adult human and animal models. In this study, we demonstrated that MeHg-induced neuropathological changes of the brain in mice were remarkable in the cerebrocortical neurons of deeper layers (dl-CCNs), but not in the CCNs of shallow layers (sl-CCNs) and the hippocampal neurons of cornu ammonis 1 (CA1-HNs). Total mercury concentration was not corresponded to the pathological changes. Here, we investigated the cause of such site-specific MeHg neurotoxicity with a focus on in situ antioxidative systems due to its critical role in MeHg intoxication...
October 13, 2017: Toxicology
https://www.readbyqxmd.com/read/29020610/neonatal-c57bl-6j-and-parkin-mice-respond-differently-following-developmental-manganese-exposure-result-of-a-high-dose-pilot-study
#18
Melanie L Foster, Thomas B Bartnikas, Hailey C Maresca-Fichter, Courtney Mercadante, Miriam Dash, Chelsea Miller, David C Dorman
It has been suggested that childhood exposure to neurotoxicants may increase the risk of Parkinson's disease (PD) or other neurodegenerative disease in adults. Some recessive forms of PD have been linked to loss-of-function mutations in the Park2 gene that encodes for parkin. The purpose of this pilot study was to evaluate whether responses to neonatal manganese (Mn) exposure differ in mice with a Park2 gene defect (parkin mice) when compared with a wildtype strain (C57BL/6J). Neonatal parkin and C57BL/6J littermates were randomly assigned to 0, 11, or 25mg Mn/kg-day dose groups with oral exposures occurring from postnatal day (PND) 1 through PND 28...
October 8, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28992350/radon-inhalation-induces-manganese-superoxide-dismutase-in-mouse-brain-via-nuclear-factor-%C3%AE%C2%BAb-activation
#19
Takahiro Kataoka, Reo Etani, Norie Kanzaki, Yusuke Kobashi, Yuto Yunoki, Tsuyoshi Ishida, Akihiro Sakoda, Yuu Ishimori, Kiyonori Yamaoka
Although radon inhalation increases superoxide dismutase (SOD) activities in mouse organs, the mechanisms and pathways have not yet been fully clarified. The aim of this study was to determine the details of SOD activation in mouse brain tissue following the inhalation of radon at concentrations of 500 or 2000 Bq/m3 for 24 h. After inhalation, brains were removed quickly for analysis. Radon inhalation increased the manganese (Mn)-SOD level and mitochondrial SOD activity. However, the differences were not significant...
September 4, 2017: Journal of Radiation Research
https://www.readbyqxmd.com/read/28977782/edaravone-attenuates-the-proinflammatory-response-in-amyloid-%C3%AE-treated-microglia-by-inhibiting-nlrp3-inflammasome-mediated-il-1%C3%AE-secretion
#20
Hong-Mei Wang, Ting Zhang, Jian-Kang Huang, Jing-Yan Xiang, Jing-Jiong Chen, Jian-Liang Fu, Yu-Wu Zhao
BACKGROUND/AIMS: Microglial activation is an important pathological feature in the brains of patients with Alzheimer's disease (AD), and amyloid-β (Aβ) peptides play a crucial role in microglial activation. In addition, edaravone (EDA) was recently shown to suppress oxidative stress and proinflammatory cytokine production in APPswePS1dE9 (APP/PS1) mice. However, the mechanism by which EDA inhibits the Aβ-induced proinflammatory response in microglia is poorly understood. METHODS: The mitochondrial membrane potential (∆ψm) was evaluated using JC-1 staining...
2017: Cellular Physiology and Biochemistry
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