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https://www.readbyqxmd.com/read/28724912/annual-variations-of-monsoon-and-drought-detected-by-gps-a-case-study-in-yunnan-china
#1
Weiping Jiang, Peng Yuan, Hua Chen, Jianqing Cai, Zhao Li, Nengfang Chao, Nico Sneeuw
The Global Positioning System (GPS) records monsoonal precipitable water vapor (PWV) and vertical crustal displacement (VCD) due to hydrological loading, and can thus be applied jointly to diagnose meteorological and hydrological droughts. We have analyzed the PWV and VCD observations during 2007.0-2015.0 at 26 continuous GPS stations located in Yunnan province, China. We also obtained equivalent water height (EWH) derived from the Gravity Recovery And Climate Experiment (GRACE) and precipitation at these stations with the same period...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28710844/reliable-hplc-separation-vibrational-circular-dichroism-spectra-and-absolute-configurations-of-isoborneol-enantiomers
#2
Rui-Qi Gao, Jun Fan, Qi Tan, Dong Guo, Tao Chen, Ru-Jian He, Dan Li, Hui Zhang, Wei-Guang Zhang
Resolution of chiral compounds has played an important role in the pharmaceutical field, involving detailed studies of pharmacokinetics, physiological, toxicological, and metabolic activities of enantiomers. Herein, a reliable method by high-performance liquid chromatography (HPLC) coupled with an optical rotation detector was developed to separate isoborneol enantiomers. A cellulose tris(3, 5-dimethylphenylcarbamate)-coated chiral stationary phase showed the best separation performance for isoborneol enantiomers in the normal phase among four polysaccharide chiral packings...
July 15, 2017: Chirality
https://www.readbyqxmd.com/read/28710791/origin-of-enhanced-vcd-in-amyloid-fibril-spectra-effect-of-deuteriation-and-ph
#3
Markéta Pazderková, Tomáš Pazderka, Maruda Shanmugasundaram, Rina K Dukor, Igor K Lednev, Laurence A Nafie
Supramolecular chirality of amyloid fibrils, protein aggregates related to many neurodegenerative diseases, is a remarkable property associated with fibril structure and polymorphism. Since its discovery almost 10 years ago there is still little understanding of this phenomenon, including the cause of the highly enhanced vibrational circular dichroism (VCD) intensity arising from fibril supramolecular chirality. In this study, VCD spectra, enhanced by filament supramolecular chirality, are presented for lysozyme and insulin fibrils above and below pH 2 and after deuterium exchange, above and below pD 2...
July 15, 2017: Chirality
https://www.readbyqxmd.com/read/28700810/to-avoid-chasing-incorrect-chemical-structures-of-chiral-compounds-raman-optical-activity-and-vibrational-circular-dichroism-spectroscopies
#4
Prasad L Polavarapu, Cody L Covington, Vijay Raghavan
A chemical structure (CS) identifies the connectivities between atoms, and the nature of those connections, for a given elemental composition. For chiral molecules, in addition to the identification of CS, the identification of the correct absolute configuration (AC) is also needed. Several chiral natural products are known whose CSs were initially mis-identified and later corrected, and these errors were often discovered during the total synthesis of natural products. In this work, we present a new and convenient approach that can be used with Raman optical activity (ROA) and vibrational circular dichroism (VCD) spectroscopies, to distinguish between the correct and incorrect CSs of chiral compounds...
July 12, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28700240/the-curious-case-of-2-propyl-1h-benzimidazole-in-the-solid-state-an-experimental-and-theoretical-study
#5
María Mar Quesada-Moreno, Aurora J Cruz-Cabeza, Juan Ramón Avilés-Moreno, Pilar Cabildo, Rosa M Claramunt, Ibon Alkorta, José Elguero, Francisco Javier Zuñiga, Juan Jesús López-González
2-Propyl-1H-benzimidazole (2PrBzIm) is a small molecule, commercially available, which displays a curious behavior in the solid state. 2PrBzIm, although devoid of chirality, by fast rotation about a single bond of the propyl group in solution, crystallizes as a conglomerate showing chiroptical properties. An exhaustive analysis of its crystal structure and a wide range of experiments monitored by VCD spectroscopy have eliminated all possibilities of an artifact. What remains is a new example of the unexplained phenomenon of persistent supramolecular chirality...
July 12, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28685956/cocaine-hydrochloride-structure-in-solution-revealed-by-three-chiroptical-methods
#6
Patrik Fagan, Lucie Kocourková, Michal Tatarkovič, František Králík, Martin Kuchař, Vladimír Setnička, Petr Bouř
Structure and flexibility of natural compounds determine their biological activity. In the present study, electronic circular dichroism (ECD), vibrational circular dichroism (VCD), and Raman optical activity (ROA) spectra of cocaine hydrochloride in aqueous solutions were measured and related to the structure with the aid of density functional theory (DFT) computations. Additional measurements in deuterated environment made assignment of vibrational bands easier. The results suggest that the prevalent cocaine conformation in solution differs from that adopted in hydrochloride crystal...
June 8, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28676874/chiroptical-properties-of-cryptophane-111
#7
Thierry Buffeteau, Delphine Pitrat, Nicolas Daugey, Nathalie Calin, Marion Jean, Nicolas Vanthuyne, Laurent Ducasse, Frank Wien, Thierry Brotin
The two enantiomers of cryptophane-111 (1), which possesses the most simplified chemical structure of cryptophane derivatives and exhibits the highest binding constant for xenon encapsulation in organic solution, were separated by HPLC using chiral stationary phases. The chiroptical properties of [CD(+)254]-1 and [CD(-)254]-1 were determined in CH2Cl2 and CHCl3 solutions by polarimetry, electronic circular dichroism (ECD), vibrational circular dichroism (VCD), and Raman optical activity (ROA) experiments and were compared to those of cryptophane-222 (2) derivative...
July 5, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28665467/single-center-comparison-of-the-efficacy-and-complications-of-arterial-vascular-closure-devices-in-interventional-radiology
#8
Matthew A Elmasri, Stephen T Kee, John M Moriarty, Antoinette Gomes, Edward W Lee, Justin P McWilliams
INTRODUCTION: Vascular closure devices (VCDs) are commonly used to achieve hemostasis of arterial access sites, but there is little comparative data on the variety of VCDs currently in clinical use. We reviewed the VCD experience at our institution to determine the safest and most effective VCD. MATERIALS AND METHODS: Retrospective analysis of 907 consecutive arterial procedures in interventional radiology from June 2012 to June 2014 was performed. Five VCDs were used: Angio-Seal (n = 478), FISH (n = 56), Mynx (n = 56), Perclose (n = 61), and Starclose (n = 68)...
June 20, 2017: Journal of Vascular Access
https://www.readbyqxmd.com/read/28650488/solvation-of-a-chiral-carboxylic-acid-effects-of-hydrogen-bonding-on-the-ir-and-vcd-spectra-of-%C3%AE-methoxyphenylacetic-acid
#9
Karoline Bünnemann, Christian Merten
Strong hydrogen bonding to solvent molecules can significantly alter the IR and VCD spectra of a chiral solute. This can be particularly troublesome for the determination of absolute configurations, as all spatial configurations of solute-solvent clusters need to be considered explicitly in spectra calculations. With this contribution, we aim to derive general guidelines for the explicit solvation of carboxylic acids, and characterize the solute-solvent interactions of the model compound α-methoxyphenylacetic acid (MPAA) in organic solvents of different polarity...
June 26, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28648533/recurrent-laryngeal-nerve-injury-and-swallowing-dysfunction-in-neonatal-aortic-arch-repair
#10
Kamal K Pourmoghadam, William M DeCampli, Mark Ruzmetov, James Kosko, Sami Kishawi, Michael O'Brien, Amanda Cowden, Kurt Piggott, Harun Fakioglu
BACKGROUND: We evaluated the incidence, clinical effect, and recovery rate of vocal cord dysfunction (VCD) and swallowing dysfunction in neonates undergoing aortic arch repair. METHODS: We retrospectively evaluated 101 neonates who underwent aortic arch reconstruction from 2008 to 2015. Direct flexible laryngoscopy was performed in 89 patients before initiation of postoperative oral feeding after Norwood (n = 63) and non-Norwood (n = 26) arch reconstruction. We defined VCD as immobility of vocal cords or their lack of coaptation and poor mobility...
June 22, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28636891/comparison-of-cyclophosphamide-thalidomide-dexamethasone-to-bortezomib-cyclophosphamide-dexamethasone-as-induction-therapy-for-multiple-myeloma-patients-in-brazil
#11
Suelen Vigolo, Joice Zuckermann, Rosane Isabel Bittencourt, Lúcia Silla, Diogo André Pilger
OBJECTIVE/BACKGROUND: Chemotherapy followed by autologous hematopoietic stem cell transplantation (HSCT) remains the standard treatment for multiple myeloma (MM). Thalidomide or bortezomib may be combined with cyclophosphamide and dexamethasone, in what are known as the CTD and VCD protocols, respectively. The objective of this study was to evaluate the clinical characteristics and response rates obtained with CTD and VCD, observing whether the inclusion of bortezomib to treat MM patients in Brazil increases therapeutic efficiency...
June 15, 2017: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/28630251/valnoctamide-inhibits-cytomegalovirus-infection-in-developing-brain-and-attenuates-neurobehavioral-dysfunctions-and-brain-abnormalities
#12
Sara Ornaghi, Lawrence S Hsieh, Angélique Bordey, Patrizia Vergani, Michael J Paidas, Anthony N van den Pol
Cytomegalovirus (CMV) is the most common infectious cause of brain defects and neurological dysfunction in developing human babies. Due to the teratogenicity and toxicity of available CMV antiviral agents, treatment options during early development are markedly limited. Valnoctamide (VCD), a neuroactive mood stabilizer with no known teratogenic activity, was recently demonstrated to have anti-CMV potential. However, it is not known whether this can be translated into an efficacious therapeutic effect to improve CMV-induced adverse neurological outcomes...
July 19, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28622306/changes-in-uninvolved-immunoglobulins-during-induction-therapy-for-newly-diagnosed-multiple-myeloma
#13
P Ravi, S Kumar, W Gonsalves, F Buadi, M Q Lacy, R S Go, A Dispenzieri, P Kapoor, J A Lust, D Dingli, Y Lin, S J Russell, N Leung, M A Gertz, R A Kyle, P L Bergsagel, S V Rajkumar
Little is known about the impact of multiple myeloma (MM) treatment on uninvolved immunoglobulins (Ig). We identified 448 patients who received high-dose dexamethasone (HD-DEX), lenalidomide and dexamethasone (RD), bortezomib and dexamethasone (VD), bortezomib, cyclophosphamide and dexamethasone (VCD) or bortezomib, lenalidomide and dexamethasone (VRD) for newly diagnosed MM at our institution between 2000 and 2013, and who had available data on absolute lymphocyte count (ALC) and quantitative uninvolved Ig at baseline and at the end of four cycles of therapy...
June 16, 2017: Blood Cancer Journal
https://www.readbyqxmd.com/read/28622303/addition-of-cyclophosphamide-and-higher-doses-of-dexamethasone-do-not-improve-outcomes-of-patients-with-al-amyloidosis-treated-with-bortezomib
#14
E Kastritis, M Gavriatopoulou, M Roussou, D Fotiou, D C Ziogas, M Migkou, E Eleutherakis-Papaiakovou, I Panagiotidis, N Kanellias, E Psimenou, E Papadopoulou, C Pamboucas, E Manios, H Gakiopoulou, A Ntalianis, A Tasidou, S Giannouli, E Terpos, M A Dimopoulos
Bortezomib, in combination with dexamethasone (VD) or with the addition of cyclophosphamide (VCD), is highly effective in patients with amyloid light-chain (AL) amyloidosis. Currently, VCD is considered as a primary regimen for patients with AL, but it is not clear whether the addition of cyclophosphamide to VD further and significantly improves efficacy, given the substantial activity of bortezomib itself. We retrospectively compared the outcomes of 101 patients with AL amyloidosis who received VD (n=59) or VCD (n=42) in two consecutive periods...
June 16, 2017: Blood Cancer Journal
https://www.readbyqxmd.com/read/28602578/femoral-arterial-haemostasis-using-an-anchored-collagen-plug-after-percutaneous-evar-with-an-ultra-low-profile-device-prospective-audit-of-an-evolving-post-close-technique
#15
A Chaudhuri
OBJECTIVE: To present an audit of a successful "post-close" haemostatic technique using the Angio-Seal VIP vascular closure device (VCD) after percutaneous endovascular aneurysm repair (p-EVAR) using an ultra-low profile (ULP) device. METHODS: Thirty patients underwent EVAR using the Ovation device, of which 26 procedures were totally percutaneous. Data including patient habitus, procedural details, number of VCDs deployed including use of the double wire approach, and technical success/complications were prospectively recorded...
June 8, 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28590076/solvent-directed-helical-stereomutation-discloses-pathway-complexity-on-n-heterotriangulene-based-organogelators
#16
Jorge S Valera, Roberto Sánchez-Naya, Francisco J Ramírez, José Luis Zafra, Rafael Gómez, Juan Casado, Luis- Sanchez
The chiroptical features of the supramolecular polymers formed by N-heterotriangulenes 1-3 have been investigated by CD and VCD dichroic techniques. In solution, the CD spectra demonstrate that the helicity of the aggregates depends only on the stereogenic centres located at the peripheral chains. In the gel state, the chiroptical features are conditioned by the point chirality of the stereogenic centres and also by the achiral solvent utilized. The sonication of the gels formed in CCl4 discloses both kinetic and thermodynamic phases...
June 7, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28584559/schisandrae-fructus-reduces-symptoms-of-4-vinylcyclohexene-diepoxide-induced-ovarian-failure-in-mice
#17
Dasom Shin, Jinhee Ha, Seong Bin Hong, Geun-Hyung Kang, Deok-Sang Hwang, Hyunsu Bae
Menopause is associated with a decrease in the level of sex hormones such as ovarian estradiol and progesterone and can cause various symptoms such as depression, hot flash, fatigue, heart palpitations, and headache. Furthermore, there is a risk of developing complications such as osteoporosis, cardiovascular diseases, Alzheimer's disease, and ovarian cancer. Schisandrae Fructus (SF) is widely used in Korean medicine as a cure for such complications. This study was conducted to evaluate the therapeutic effects of SF against menopause symptoms associated with follicle depletion caused by the industrial chemical 4-vinylcyclohexene diepoxide (VCD) in mice...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28577694/manual-compression-versus-vascular-closing-device-for-closing-access-puncture-site-in-femoral-left-heart-catheterization-and-percutaneous-coronary-interventions-a-retrospective-cross-sectional-comparison-of-costs-and-effects-in-inpatient-care
#18
COMPARATIVE STUDY
Julia Walter, Matthias Vogl, Martin Holderried, Christian Becker, Alina Brandes, Moritz F Sinner, Wolf Rogowski, Jens Maschmann
OBJECTIVES: To compare complication rates, length of hospital stay, and resulting costs between the use of manual compression and a vascular closing device (VCD) in both diagnostic and interventional catheterization in a German university hospital setting. METHODS: A stratified analysis according to risk profiles was used to compare the risk of complications in a retrospective cross-sectional single-center study. Differences in costs and length of hospital stay were calculated using the recycled predictions method, based on regression coefficients from generalized linear models with gamma distribution...
June 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28577348/chirality-induction-from-a-chiral-guest-to-the-hydrogen-bonding-network-of-its-hexameric-resorcinarene-host-capsule
#19
Corina H Pollok, Qi Zhang, Konrad Tiefenbacher, Christian Merten
The hexameric capsule of resorcin[4]arene 1 is capable of encapsulating tertiary amines,which has recently successfully been taken advantage of in the application of [(1)6(H2O)8] as (co-)catalyst in various asymmetric reactions. However,not much is known about the highly asymmetric but conformationally very dynamic structure of the capsule after uptake of chiral molecules. Therefore, in this contribution, we utilize ECD and VCD spectroscopy to investigate how several chiral guest molecules affect the structural preferences of the capsule [(1)6(H2O)8]...
June 3, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28566938/safety-and-efficacy-of-a-novel-hybrid-closure-technique-in-large-bore-arteriotomies
#20
Michael K Amponsah, Rajiv Tayal, Zain Khakwani, Michael Sinclair, Najam Wasty
The "preclose" technique employing two Perclose (P) devices is well established for large-bore artery (LBA) hemostasis. Occasionally, only one Perclose deploys successfully during the initial preclose because of arterial calcification necessitating the use of the crossover balloon technique to achieve hemostasis at the LBA. We sought to determine if the combined use of one Perclose and either one Angioseal or one Mynx vascular closure device (VCD) is a safe alternative closure technique large-bore arteriotomy closure...
June 2017: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
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