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https://www.readbyqxmd.com/read/28530134/effect-of-intraoperative-positioning-on-the-diameter-of-the-vertebral-canal-in-cats-during-perineal-urethrostomy-cadaveric-study
#1
Pavel Slunsky, Mathias Brunnberg, Shenja Lodersted, Leo Brunnberg
Objectives The objective of this study was to quantify the changes in the diameter of the vertebral canal in the lumbosacral and sacrococcygeal column (L6-Co2) in cats in dorsal and ventral recumbency, simulating real body positioning during a perineal urethrostomy. Methods Twenty-one male feline cadavers were enrolled in the study. All feline cadavers were evaluated by CT. Examinations were performed with the cadaver in a neutral position and dorsal and ventral recumbency. Sagittal vertebral canal diameters (VCDs) were obtained by measuring the distance between the ventral and dorsal aspects of the vertebral canal in the middle of the intervertebral space...
May 1, 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/28520882/ocular-determinants-of-refractive-error-and-its-age-and-sex-related-variations-in-the-chinese-american-eye-study
#2
Grace M Richter, Mingwu Wang, Xuejuan Jiang, Shuang Wu, Dandan Wang, Mina Torres, Farzana Choudhury, Rohit Varma
Importance: Uncorrected refractive error (RE) is a leading cause of visual impairment, and variations in ocular anatomy determine RE. The unique ocular determinants of RE in Chinese American individuals have not been studied previously. Objective: To report ocular determinants of RE in a Chinese American population 50 years and older in Monterey Park, California. Design, Setting, and Participants: The Chinese American Eye Study, a population-based, cross-sectional study, was conducted from February 1, 2010, through October 31, 2013, in Monterey Park, with this particular data analysis performed from January 1 through December 31, 2016...
May 18, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28515016/determination-of-the-absolute-configuration-of-a-novel-tetrasubstituted-isoindolinone-by-vibrational-circular-dichroism
#3
Antonio Massa, Paola Rizzo, Francesco Scorzelli, Guglielmo Monaco, Riccardo Zanasi
The absolute configuration of a recently prepared asymmetric 3,3-disubstituted isoindolinone (ethyl 2-benzyl-3-oxo-1-(3-oxobutyl)isoindoline-1-carboxylate), possessing highly promising pharmaceutical activity, has been determined by means of VCD spectroscopy and DFT calculations. The great flexibility of the molecule reduces to a few relevant conformers, all contributing in the same way to the shape of the VCD spectrum for the carbonyl stretching region. Two of the three CO groups of the molecule interact with each other during the stretching vibration, thus providing a non-conservative VCD couplet whose signature, together with the VCD sign of the third CO stretching mode, unequivocally determines the absolute configuration of the molecule, which is found to be (S) for the (-) optical isomer...
May 4, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28500975/valnoctamide-which-reduces-rat-brain-arachidonic-acid-turnover-is-a-potential-non-teratogenic-valproate-substitute-to-treat-bipolar-disorder
#4
Hiren R Modi, Kaizong Ma, Lisa Chang, Mei Chen, Stanley I Rapoport
BACKGROUND: Valproic acid (VPA), used for treating bipolar disorder (BD), is teratogenic by inhibiting histone deacetylase. In unanaesthetized rats, chronic VPA, like other mood stabilizers, reduces arachidonic acid (AA) turnover in brain phospholipids, and inhibits AA activation to AA-CoA by recombinant acyl-CoA synthetase-4 (Acsl-4) in vitro. Valnoctamide (VCD), a non-teratogenic constitutional isomer of VPA amide, reported effective in BD, also inhibits recombinant Acsl-4 in vitro...
April 26, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28497297/assessing-the-influence-of-different-plant-species-in-drainage-ditches-on-mitigation-of-non-point-source-pollutants-n-p-and-sediments-in-the-purple-sichuan-basin
#5
Mathieu Nsenga Kumwimba, Bo Zhu, Diana Kavidia Muyembe
Three different types of ditches, each 300 m in length, were employed in this study. One vegetated constructed ditch (VCD), three natural vegetated soil ditches (NVSD), and three constructed ditches left unvegetated (UCD) as controls were investigated using simple in/out mass balances and uptake by plant species with a potential for phytoremediation and their mechanisms. Significant differences in the ditches were observed, suggesting the importance of plant species in nutrient mitigation. The removal rates of TN (total nitrogen) and TP (total phosphorus) were 64...
June 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28436688/a-vibrational-circular-dichroism-microsampling-accessory-mapping-enhanced-vibrational-circular-dichroism-in-amyloid-fibril-films
#6
Xuefang Lu, Honggang Li, Jordan W Nafie, Tomáš Pazderka, Markéta Pazderková, Rina K Dukor, Laurence A Nafie
We report the first vibrational circular dichroism (VCD) measurement of spatial heterogeneity in a sample using infrared (IR) microsampling. Vibrational circular dichroism spectra are typically measured using a standard IR cell with an IR beam diameter of 10 mm or greater making it impossible to investigate the spatial heterogeneity of a solid film sample. We have constructed a VCD sampling assembly with either 3 mm or 1 mm spatial resolution. An XY-translation stage was used to measure spectra at different spatial locations producing IR and VCD maps of the sample...
January 1, 2017: Applied Spectroscopy
https://www.readbyqxmd.com/read/28436530/solvent-free-uncatalyzed-asymmetric-ene-reactions-of-n-tert-butylsulfinyl-3-3-3-trifluoroacetaldimines-a-general-approach-to-enantiomerically-pure-%C3%AE-trifluoromethyl-tryptamines
#7
Giuseppe Mazzeo, Giovanna Longhi, Sergio Abbate, Martina Palomba, Luana Bagnoli, Francesca Marini, Claudio Santi, Jianlin Han, Vadim A Soloshonok, Emilio Di Crescenzo, Renzo Ruzziconi
A novel approach to regioselectively substituted and stereoselectively α-trifluoromethylated tryptamines is reported based on the ene reaction of Boc-protected 3-methyleneindolines with optically pure (R)- or (S)-tert-butanesulfinyltrifluoroacetaldimine. Boc- and sulfinylamido-protected α-trifluoromethyltryptamines are obtained in 60-70% yield and 85/15 dr by just heating equimolar amounts of the two reaction partners at 80-90 °C for 2-3 h without a solvent. The absolute configuration of the amino α-carbon has been assigned based on the vibrational circular dichroism (VCD) spectral analysis...
May 10, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28430699/clinical-experience-and-diagnostic-algorithm-of-vulval-crohn-s-disease
#8
Lotte Boxhoorn, Tom J Stoof, Tim de Meij, Frank Hoentjen, Bas Oldenburg, Gerd Bouma, Mark Löwenberg, Adriaan A van Bodegraven, Nanne K H de Boer
BACKGROUND AND AIM: Vulval Crohn's disease (VCD) is a rare extraintestinal cutaneous manifestation of Crohn's disease. No consensus on the diagnostic workup and therapeutic management of this condition has been provided in the current literature. PATIENTS AND METHODS: Retrospective, multicentre descriptive case series of female patients diagnosed and treated with VCD. By chart review, data on initial symptoms, clinical courses, histologic findings and therapeutic management were collected...
April 20, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28425425/skeletal-anomalies-in-reared-senegalese-sole-solea-senegalensis-juveniles-a-radiographic-approach
#9
A M de Azevedo, A P Losada, A Barreiro, J D Barreiro, I Ferreiro, A Riaza, S Vázquez, M I Quiroga
Reared Senegalese sole Solea senegalensis Kaup show a high incidence of vertebral anomalies; however, little is known about its skeletal anomaly profile in the later farming phases. The purpose of this study was to provide a detailed description and quantification of the most common skeletal anomalies in reared Senegalese sole in the juvenile stage by means of computed radiography. A total of 374 Senegalese sole were classified according to the external morphology of the fish as normal or altered and then radiographed in latero-lateral and in dorso-ventral projections...
April 20, 2017: Diseases of Aquatic Organisms
https://www.readbyqxmd.com/read/28409838/modulation-and-modeling-of-monoclonal-antibody-n-linked-glycosylation-in-mammalian-cell-perfusion-reactors
#10
Daniel J Karst, Ernesto Scibona, Elisa Serra, Jean-Marc Bielser, Jonathan Souquet, Matthieu Stettler, Hervé Broly, Miroslav Soos, Massimo Morbidelli, Thomas K Villiger
Mammalian cell perfusion cultures are gaining renewed interest as an alternative to traditional fed-batch processes for the production of therapeutic proteins, such as monoclonal antibodies (mAb). The steady state operation at high viable cell density allows the continuous delivery of antibody product with increased space-time yield and reduced in-process variability of critical product quality attributes (CQA). In particular, the production of a confined mAb N-linked glycosylation pattern has the potential to increase therapeutic efficacy and bioactivity...
April 14, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/28403568/preparative-chiral-separation-and-absolute-configuration-of-the-synthetic-pterocarpanquinone-lqb-118
#11
Gabriel S Scatena, Neila M Cassiano, Chaquip D Netto, Paulo R R Costa, Quezia B Cass, João M Batista
The racemic pterocarpanquinone LQB-118 is active, in mice and hamsters, against tegumentary and visceral leishmaniasis. This compound also presents antiinflammatory and antineoplastic activity in mice. The low level of toxicity observed in these studies makes LQB-118 a promising drug candidate. In order to conduct further biological testing to investigate enantioselectivity in the above-mentioned activities, a multimilligram amount of each enantiomer of LQB-118 was produced. Furthermore, vibrational circular dichroism (VCD) and Density Functional Theory (DFT) calculations were used to determine unambiguously their absolute configurations...
May 2017: Chirality
https://www.readbyqxmd.com/read/28403537/cdspectech-a-single-software-suite-for-multiple-chiroptical-spectroscopic-analyses
#12
Cody L Covington, Prasad L Polavarapu
The program CDSpecTech was developed to facilitate the analysis of chiroptical spectra, which include the following: vibrational circular dichroism (VCD) and corresponding vibrational absorption (VA) spectra; vibrational Raman optical activity (VROA) and corresponding vibrational Raman spectra; electronic circular dichroism (ECD) and corresponding electronic absorption (EA) spectra. In addition, the program allows for generating optical rotatory dispersion (ORD) as the Kramers-Kronig transform of ECD spectra...
May 2017: Chirality
https://www.readbyqxmd.com/read/28370488/asymmetric-sequential-cu-catalyzed-1-6-1-4-conjugate-additions-of-hard-nucleophiles-to-cyclic-dienones-determination-of-absolute-configurations-and-origins-of-enantioselectivity
#13
Marc Mauduit, Charlie Blons, Marie S T Morin, Thibault E Schmid, Thomas Vives, Sophie Colombel-Rouen, Olivier Baslé, Thibault Reynaldo, Cody L Covington, Stephanie Halbert, Sean N Cuskelly, Paul V Bernhardt, Craig M Williams, Jeanne Crassous, Prasad L Polavarapu, Christophe Crévisy, Hélène Gérard
The first stereo-controlled Cu-catalyzed sequential 1,6/1,4-asymmetric conjugate addition (ACA) of C-metalated hard nucleophiles to cyclic dienones is reported. The use of DiPPAM, followed by a phosphoramidite, as the stereoinducing ligands facilitated both high ee's for the 1,6-ACA and high de's for the 1,4-ACA reaction components, thus affording enantio-enriched 1,3-dialkylated moieties. The absolute configurations were determined using vibrational circular dichroism (VCD) and optical rotatory dispersion (ORD) spectroscopy, in combination with DFT calculations and X-Ray analysis...
April 3, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28363061/compromised-fertility-in-free-feeding-of-wild-caught-norway-rats-rattus-norvegicus-with-a-liquid-bait-containing-4-vinylcyclohexene-diepoxide-and-triptolide
#14
Gary W Witmer, Stefanie Raymond-Whish, Rachael S Moulton, Brandy R Pyzyna, Elissa M Calloway, Cheryl A Dyer, Loretta P Mayer, Patricia B Hoyer
Wild rat pests in the environment cause crop and property damage and carry disease. Traditional methods of reducing populations of these pests involve poisons that can cause accidental exposures in other animals and humans. Fertility management with nonlethal chemicals would be an improved method of rat pest population control. Two chemicals known to target ovarian function in female rats are 4-vinylcyclohexene diepoxide (VCD) and triptolide. Additionally, triptolide impairs spermatogenesis in males. A liquid bait containing no active ingredients (control), or containing triptolide (0...
March 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28338625/-r-aloesaponol-iii-8-methyl-ether-from-eremurus-persicus-a-novel-compound-against-leishmaniosis
#15
Daniela Rossi, Karzan Mahmood Ahmed, Raffaella Gaggeri, Serena Della Volpe, Lauretta Maggi, Giuseppe Mazzeo, Giovanna Longhi, Sergio Abbate, Federica Corana, Emanuela Martino, Marisa Machado, Raquel Varandas, Maria do Céu Sousa, Simona Collina
Leishmaniosis is a neglected tropical disease which affects several millions of people worldwide. The current drug therapies are expensive and often lack efficacy, mainly due to the development of parasite resistance. Hence, there is an urgent need for new drugs effective against Leishmania infections. As a part of our ongoing study on the phytochemical characterization and biological investigation of plants used in the traditional medicine of western and central Asia, in the present study, we focused on Eremurus persicus root extract in order to evaluate its potential in the treatment of leishmaniosis...
March 24, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28335899/percutaneous-plug-based-arteriotomy-closure-device-for-large-bore-access-a-multicenter-prospective-study
#16
Nicolas M Van Mieghem, Azeem Latib, Jan van der Heyden, Lennart van Gils, Joost Daemen, Todd Sorzano, Jurgen Ligthart, Karin Witberg, Thom de Kroon, Nathaniel Maor, Antonio Mangieri, Matteo Montorfano, Peter P de Jaegere, Antonio Colombo, Gary Roubin
OBJECTIVES: The authors sought to study the safety and efficacy of the MANTA Vascular Closure Device (VCD), a novel collagen-based technology dedicated to closure of large-bore arteriotomies. BACKGROUND: Novel transfemoral therapeutic interventions requiring large-bore catheters have become valid minimally invasive options but have inherent access management challenges. To date, no dedicated vascular closure devices exist for large arteriotomies. METHODS: A prospective, single-arm clinical investigation enrolling patients who underwent elective percutaneous interventions with large-bore catheters and planned percutaneous arteriotomy closure in 3 European institutions...
March 27, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28315381/alfa-helix-to-beta-sheet-transition-in-long-chain-poly-l-lysine-formation-of-alfa-helical-fibrils-by-poly-l-lysine
#17
Katarzyna Cieślik-Boczula
The temperature-induced α-helix to β-sheet transition in long-chain poly-l-lysine (PLL), accompanied by the gauche-to-trans isomerization of CH2 groups in the hydrocarbon side chains of Lys amino acid residues, and formation of β-sheet as well as α-helix fibrillar aggregates of PLL have been studied using Fourier-transform infrared (FT-IR) and vibrational circular dichroism (VCD) spectroscopy, and transmission electron microscopy (TEM). In a low-temperature alkaline water solution or in a methanol-rich water mixture, the secondary structure of PLL is represented by α-helical conformations with unordered and gauche-rich hydrocarbon side chains...
March 14, 2017: Biochimie
https://www.readbyqxmd.com/read/28296143/targeting-the-safe-zone
#18
Andrea Mignatti, Patricia Friedmann, David Paul Slovut
OBJECTIVE: The aim of this study was to assess the effectiveness of a quality improvement (QI) program in reducing vascular complications during cardiac catheterization. BACKGROUND: Vascular access complications during cardiac catheterization are associated with higher morbidity and mortality. We implemented a QI program focused on using micropuncture techniques and targeting the "safe zone," an area below the inferior border of the inferior epigastric artery and above the inferior border of the femoral head, for femoral artery puncture...
March 15, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28294053/absolute-configuration-determination-by-quantum-mechanical-calculation-of-chiroptical-spectra-basics-and-applications-to-fungal-metabolites
#19
Stefano Superchi, Patrizia Scafato, Marcin Górecki, Gennaro Pescitelli
The application of quantum mechanical simulation of chiroptical properties, i.e. electronic circular dichroism (ECD), optical rotation (OR), and vibrational circular dichroism (VCD), to the assignment of the absolute configuration of chiral naturally occurring metabolites of fungal origin, is reviewed. The fundamentals of such chiroptical spectroscopies as well as the specific experimental and computational issues allied to the application of their ab initio calculation is reported. Some examples, related to the use of the ECD, VCD, and OR techniques and highlighting the practical application of the methods, are also described...
March 10, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28290589/vibrational-circular-dichroism-and-single-crystal-x-ray-diffraction-analyses-of-ir-bzq-2-phen-bzq-benzo-h-quinoline-phen-1-10-phenanthroline-absolute-configuration-and-role-of-ch-%C3%AF-interaction-in-molecular-packing
#20
Kazuyoshi Takimoto, Yutaka Watanabe, Shigeki Mori, Hisako Sato
Vibrational circular dichroism (VCD) spectra are measured for dichloromethane solutions of the resolved enantiomers of [Ir(bzq)2(phen)](+) (bzqH = benzo[h]quinoline; phen = 1,10-phenanthroline). The absolute configuration of each enantiomer is determined by comparing the experimental and theoretical spectra. The result is in accord with the results of the X-ray single crystallographic analysis on the enantiomeric crystal. Moreover, the importance of the CH-π interaction is derived between phen and a hydrogen atom in bzq in the molecular packing of both the enantiomeric and racemic crystals...
March 27, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
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