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Carcinoma cervix

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https://www.readbyqxmd.com/read/28522860/involvement-of-fak-erk2-signaling-pathway-in-ckap2-induced-proliferation-and-motility-in-cervical-carcinoma-cell-lines
#1
Qi-Sang Guo, Yu Song, Ke-Qin Hua, Shu-Jun Gao
Cervical carcinoma is the fourth most common cause of death in woman, caused by human papillomavirus (HPV) infections and arising from the cervix. Cytoskeleton-associated protein 2 (CKAP2), also known as tumor-associated microtubule-associated protein, has been linked to tumorigenic effects. In the present study, we screened CKAP2 as a new candidate gene which promotes development of cervical carcinoma, in two independent datasets (TCGA and GSE27678). Results showed that CKAP2 expression was significantly up-regulated in cervical cancerous tissues compared with normal counterparts...
May 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28522321/why-do-we-continue-to-over-treat-stage-ia-carcinoma-of-the-cervix
#2
Tommy Buchanan, Jennifer Young Pierce, Whitney Graybill, Matthew Kohler, William Creasman
The current recommended treatment for stage Ia2 cervical cancer is a radical or modified radical hysterectomy. Although in the United States the incidence of cervical cancer is low and declining, almost 50% of the over 4,000 new cases will present in early stages. An estimated 2,200 women each year will undergo radical hysterectomy and many will suffer from both early- and late-onset complications. The purpose of this review is to examine if there is still a role for radical hysterectomy in the proper treatment of stage Ia2 cervical cancer given most recent data...
May 15, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28522318/survival-of-women-with-microinvasive-adenocarcinoma-of-the-cervix-is-not-improved-by-radical-surgery
#3
Lisa M Bean, Kristy K Ward, Steven C Plaxe, Michael T Mchale
BACKGROUND: Treatment for early-invasive adenocarcinoma of the cervix remains controversial. Although data have shown similar survival rates to those seen with squamous cell carcinoma, conservative options for patients with microinvasive adenocarcinoma have not been as widely accepted. Despite comparable survival outcomes, patients with early-invasive adenocarcinoma are still routinely subjected to more radical surgical techniques than their equivalently staged squamous cell counterparts...
May 15, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28515922/primary-primitive-neuroectodermal-tumor-of-the-cervix-a-report-of-two-cases-and-review-of-the-literature
#4
Xiaofeng Wang, Yan Gao, Yanning Xu, Yixin Liu, Pengpeng Qu
Peripheral primitive neuroectodermal tumor (PNET) of the cervix uteri is extremely rare. Two cases of PNET of the cervix are presented herein. Two female patients, aged 48 and 43 years, presented with irregular uterine bleeding over the course of 1 year, and increased urinary frequency for 1 month, respectively. On gynecological examination, a mass in the cervix was palpated and a biopsy performed. The findings of the initial biopsy revealed small-cell carcinoma in both patients. Following neoadjuvant chemotherapy and radiotherapy, radical hysterectomy was performed in both patients...
May 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28515918/synchronous-primary-malignant-neoplasms-of-the-cervix-and-endometrium
#5
Shulan Lv, Xue Xue, Yanxia Sui, Juang Du, Junkai Zou, Chao Sun, Dong Liu, Qing Song, Qiling Li
Synchronous multiple malignant neoplasms of the female genital tract are rare, particularly in the uterus. We herein present the case of a patient with synchronous cervical squamous epithelial carcinoma and endometrial adenocarcinoma, and discuss the diagnosis, treatment and prognosis. The patient underwent a cervical biopsy and fractional curettage of the endometrium, followed by abdominal staging surgery, including radical hysterectomy, bilateral salpingo-oophorectomy, pelvic and para-aortic lymphadenectomy...
May 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28509325/an-alternative-approach-to-gynecological-wound-healing
#6
Jakub Rzepka, Katarzyna Mosoń, Romuald Dębski
An 89-year-old woman was reffered to our Clinic with vulvar cancer. She also suffered from obesity [with body mass index (BMI) 35 kg/m2], persistent hypertension, diabetes mellitus type 2 treated with oral medications. In 2015 she underwent a surgery due to endometrial carcinoma. Total abdominal hysterectomy with bilateral salphingoophorectomy, omentectomy and pelvical node dissection was performed (histopathology revealed adenocarcinoma serosum G2; FIGO stage Ib). In January 2016 after vulvar ulceration biopsy plano-epithelial squamous vulvar cancer was diagnosed...
2017: Ginekologia Polska
https://www.readbyqxmd.com/read/28508846/assessment-of-three-dimensional-setup-errors-in-image-guided-pelvic-radiotherapy-for-uterine-and-cervical-cancer-using-kilovoltage-cone-beam-computed-tomography-and-its-effect-on-planning-target-volume-margins
#7
Nidhi Patni, Nagarjuna Burela, Rajesh Pasricha, Jaishree Goyal, Tej Prakash Soni, T Senthil Kumar, T Natarajan
PURPOSE: To achieve the best possible therapeutic ratio using high-precision techniques (image-guided radiation therapy/volumetric modulated arc therapy [IGRT/VMAT]) of external beam radiation therapy in cases of carcinoma cervix using kilovoltage cone-beam computed tomography (kV-CBCT). MATERIALS AND METHODS: One hundred and five patients of gynecological malignancies who were treated with IGRT (IGRT/VMAT) were included in the study. CBCT was done once a week for intensity-modulated radiation therapy and daily in IGRT/VMAT...
January 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28504849/diagnosis-and-treatment-of-cervical-papillary-squamous-cell-carcinoma-with-unknown-depth-of-stromal-invasion
#8
Xuyin Zhang, Jingxin Ding, Xiang Tao, Huijun Qian, Keqin Hua
OBJECTIVE: To evaluate the diagnosis and treatment of papillary squamous cell carcinoma (PSCC) of the uterine cervix with unknown depth of stromal invasion. METHODS: In a retrospective study, the diagnostic and treatment strategies after colposcopy-guided biopsy sampling were assessed among patients seen at a university hospital in Shanghai, China, in 2008-2015. RESULTS: Among 55 patients, 29 with clinically visible lesions underwent radical hysterectomy; the final pathologic diagnosis was invasive squamous cell carcinoma in all patients...
May 15, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28501984/pediatric-gynecologic-cancers
#9
REVIEW
Lauren Pommert, William Bradley
PURPOSE OF REVIEW: Three primary categories of gynecologic cancer are found in pediatric and adolescent patients: stromal carcinomas including juvenile granulosa cell tumors and Sertoli-Leydig cell tumors, rhabdomyosarcomas arising from the vagina and cervix (sarcoma botryoides), and ovarian germ cell tumors which comprise a wide range of histologies. These entities are rare and treatment approaches have focused on decreasing late effects of chemotherapy treatment. Here, we review presentation, histologic classifications, diagnosis, and treatment recommendations for pediatric gynecologic cancers...
July 2017: Current Oncology Reports
https://www.readbyqxmd.com/read/28499169/two-novel-dinuclear-ellipsoid-ni-ii-and-co-ii-complexes-bridged-by-4-5-bis-pyrazol-1-yl-phthalic-acid-synthesis-structural-characterization-and-biological-evaluation
#10
Enjun Gao, Zhenzhen Qi, Yun Qu, Yuqing Ding, Yang Zhan, Na Sun, Shaozhong Zhang, Xue Qiu, Mingchang Zhu
Two novel complexes, [Ni2(L)2(H2O)3]·4(H2O) (1) and [Co2(L)2(H2O)3]·5(H2O) (2) [H2L = 4,5-bis(pyrazol-1-yl) phthalic acid] were synthesized and characterized by spectroscopy (IR, (1)H NMR), and elemental analysis. The structures for the complexes were determined by X-ray crystallography providing the dinuclear ellipsoid Ni(II) and Co(II) complexes bridged by 4,5-bis(pyrazol-1-yl)phthalic acid ligands with same coordination modes. The interaction capacity of the complexes with FS-DNA (fish sperm DNA) has been investigated by UV and fluorescence spectroscopy...
May 4, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28498727/good-prognosis-went-badly-fulminant-evolution-of-a-29-year-old-patient-with-verrucous-carcinoma-of-the-cervix
#11
Rodica M Anghel, Oana G Trifanescu, Radu I Mitrica, Fabiana G Curea, Inga Botnariuc, Catalin G Herghelegiu, Cristina M Orlov, Silvia M Ilie
Verrucous carcinoma (VC) is a very rare variant of squamous cell carcinoma of the cervix, difficult to point out in histology because of its benign appearance. We present the case of a 29-year-old woman with a locally advanced cervical VC who underwent radiotherapy followed by radical hysterectomy. After local relapse and despite pelvic exenteration, her condition deteriorated. Treatment of choice in VC is surgery, because of the risk of anaplastic transformation under irradiation, raising the chances of distant spread and converting this rather benign-like type of cancer to an aggressive cancer...
May 12, 2017: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/28498261/clear-cell-carcinoma-of-the-uterine-cervix-a-clinical-and-pathological-analysis-of-47-patients-without-intrauterine-diethylstilbestrol-exposure
#12
Li Yang, Aiwen Zheng, Xiang Zhang, Xianhua Fang, Wenyong Sun, Yaqing Chen
OBJECTIVES: The aim of this study was to summarize the clinical and pathological characteristics and to conduct prognosis analysis of patients who were diagnosed with clear cell carcinoma of the uterine cervix (CCCUC) and without a history of exposure to diethylstilbestrol. METHODS: We performed a retrospective review of all the patients with CCCUC who were diagnosed and treated at Zhejiang Cancer Hospital between 1998 and 2014. Charts were reviewed for clinical and pathological characteristics, and prognosis analysis was conducted...
June 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28498239/the-validity-of-using-human-squamous-cell-carcinoma-associated-antigen-and-cytokeratin-19-fragment-antigen-21-1-to-predict-postoperative-adjuvant-radiotherapy-for-nonbulky-early-stage-squamous-cell-carcinoma-of-the-cervix
#13
Chan-Zhen Liu, Hao-Xia Zeng, Jing-Jing Zhao, Yan Rong, Zhe-Lun Mo, Li A Li, Jie-Qing Zhang
OBJECTIVE: There are no generally accepted biomarkers for the optimal selection of radiotherapy-based or surgical-based treatment options for nonbulky early-stage squamous cell carcinoma of the cervix (IA1-IB1 and IIA1). The objective of this study was to assess the value of human squamous cell carcinoma-associated antigen (SCC-Ag) and cytokeratin 19 fragment antigen 21-1 (CYFRA21-1) in evaluation of patients with nonbulky early-stage squamous cell carcinoma of the cervix to determine if radiotherapy is warranted after radical surgery...
June 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28495482/-recurrence-of-a-glassy-cell-carcinoma-of-the-vagina-an-exceptional-situation
#14
Y Yahiaoui, A Gabsi, R Doghri, M Ayadi, K Mrad, A Mezlini
Glassy cell carcinoma is a rare neoplasm that occurs most frequently in the uterine cervix. We describe the second reported case of glassy cell carcinoma arising in the vagina. We present a case of a 24-year-old woman with a history of post-coïtal bleeding associated with menometrorrhagia. Different explorations have concluded in a glassy cell carcinoma arising in the vagina, with clinical staging III according to the International Federation of Obstetrics and Gynecology. The patient received three cycles of neoadjuvant chemotherapy with a good response...
May 8, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28489796/leptomeningeal-metastasis-of-poorly-differentiated-uterine-cervical-adenosquamous-carcinoma-following-reirradiation-to-metastatic-vertebrae-a-case-report
#15
Yueh-Feng Lu, Vai Hong Fong, Wen-Yih Wu, Li-Ying Wang, Chen-Hsi Hsieh
RATIONALE: Leptomeningeal metastasis from cervical adenosquamous carcinoma is extremely rare especially after radiotherapy for vertebral metastasis. PATIENT CONCERNS: A 52-year-old woman with International Federation of Gynecology and Obstetrics (FIGO) stage IIB adenosquamous carcinoma of cervix presented with bilateral lower limbs weakening after 2 courses radiotherapy to thoracic vertebral metastases. DIAGNOSES: Initial spine magnetic resonance imaging (MRI) showed no obvious nerve compression, and radiation myelopathy was suspected by the clinician...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28489772/primary-diffuse-large-b-cell-lymphoma-of-the-uterine-cervix-successfully-treated-by-combined-chemotherapy-alone-a-case-report
#16
Ana María Cubo, Zandra Mileny Soto, Miguel Ángel Cruz, María José Doyague, Verónica Sancho, Aurymar Fraino, Óscar Blanco, Noemi Puig, Miguel Alcoceba, Marcos González, José María Sayagués
RATIONALE: Primary lymphomas of the uterine cervix are a rare disease. They are often misdiagnosed because of their rarity and because they can be easily confused with a squamous cell carcinoma of the cervix, as they are usually presented as exophytic mass with vaginal bleeding as their most common symptoms. Nevertheless, considering that both the prognosis and the treatment are completely different between them, differential diagnosis should be taken into account. PATIENT CONCERNS: A case of a 51-year-old woman with a primary diffuse large B-cell lymphoma of the cervix is presented...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28469347/squamous-cell-carcinoma-in-situ-of-the-cervix-with-superficial-intraepithelial-extension-to-the-endometrium-of-lower-uterine-segment-a-rare-presentation
#17
Rajeshwari K Muthusamy, Sangita S Mehta
Carcinoma of the cervix is the most common malignancy in women in India. Squamous cell carcinoma accounts for more than 70% of the cervical malignancies. Carcinoma of the cervix generally invades the uterine wall by direct extension with or without parametrial involvement, however, rarely can spread superficially to the inner surface of the uterus replacing the endometrium. It is an uncommon phenomenon for an in situ lesion of the cervix to have contiguous superficial spread to the endometrium. We report a case of cervical in situ squamous cell carcinoma in a 45-year-old female with contiguous extension to the endometrium of the lower uterine segment...
January 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/28469317/impact-of-surepath-%C3%A2-liquid-based-preparation-in-cytological-analysis-of-peritoneal-washing-in-practice-of-gynecologic-oncology
#18
Ruchita Tyagi, Nalini Gupta, Priyanka Bhagat, Shalini Gainder, Bhavna Rai, L K Dhaliwal, Arvind Rajwanshi
CONTEXT: Peritoneal washing is performed for staging of gynecologic tumors to detect subclinical intraperitoneal metastases. AIM: The aim of the present study was to assess the impact of SurePath™ liquid-based cytology (LBC) in peritoneal washing in various gynecological malignancies. SETTINGS AND DESIGN: An audit of peritoneal-fluid/washing (January 2012 to July 2013) was performed with corresponding gynecologic specimens. All peritoneal washings were processed using both conventional and LBC technique...
April 2017: Journal of Cytology
https://www.readbyqxmd.com/read/28464838/primary-extragenital-endometrial-stromal-sarcoma-of-the-lung-first-reported-case-and-review-of-literature
#19
Lara Alessandrini, Francesco Sopracordevole, Giulio Bertola, Simona Scalone, Martina Urbani, Gianmaria Miolo, Tiziana Perin, Fabrizio Italia, Vincenzo Canzonieri
BACKGROUND: Endometrial stromal sarcomas arising in extrauterine and extraovarian sites, in the absence of a primary uterine lesion are quite rare, especially in the absence of endometriosis. They usually present as an abdominal or pelvic mass lesion. CASE PRESENTATION: In 2007, a 45-year-old woman underwent total hysterectomy for in situ squamous cell carcinoma of the cervix. In 2014, an upper left pulmonary lobectomy was performed for a mass, which was provisionally diagnosed as primary carcinosarcoma of the lung...
May 2, 2017: Diagnostic Pathology
https://www.readbyqxmd.com/read/28454301/immunohistochemical-profile-of-ing3-protein-in-normal-and-cancerous-tissues
#20
Wen-Feng Gou, Xue-Feng Yang, Dao-Fu Shen, Shuang Zhao, Hong-Zhi Sun, Jun-Sheng Luo, Hua-Chuan Zheng
The inhibitor of growth family, member 3 (ING3) protein may be capable of blocking the cell cycle via activating p53-transactivated promoters of p21 and Bcl2-associated X protein, and may induce apoptosis via a Fas/caspase-8-dependent signaling pathway. In the present study, immunohistochemistry was performed in order to characterize the expression profile of ING3 protein in tissue microarrays containing mouse and human normal tissue, human hepatocellular (n=62), renal clear cell (n=62), pancreatic (n=62), esophageal squamous cell (n=45), cervical squamous cell (n=31), breast (n=144), gastric (n=196), colorectal (n=96), ovarian (n=208), endometrial (n=96) and lung carcinoma (n=192)...
March 2017: Oncology Letters
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