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cervical ripening

Arpita Ghosh, Katherine R Lattey, Anthony J Kelly
BACKGROUND: Sometimes it is necessary to bring on labour artificially because of safety concerns for the mother or baby. This review is one of a series of reviews of methods of labour induction using a standardised protocol. OBJECTIVES: To determine the effects of NO donors (isosorbide mononitrate (ISMN), isosorbide dinitrate (ISDN), nitroglycerin and sodium nitroprusside) for third trimester cervical ripening or induction of labour, in comparison with placebo or no treatment or other treatments from a predefined hierarchy...
December 5, 2016: Cochrane Database of Systematic Reviews
James A Bofill, Marie M Darby, Javier Castillo, Sandip U Sawardecker, Everett F Magann, John C Morrison
PURPOSE: This study was aimed at determining if significant uterine tachysystole was associated with adverse fetal or neonatal outcomes during cervical ripening and induction of labor. METHODS: Women undergoing cervical ripening and subsequent labor induction (n = 905) were assessed for tachysystole, defined as ≥6 contractions in each of 2 consecutive 10-minute windows. Women with ≥3 episodes of tachysystole were compared to women with no tachysystole. RESULTS: Over a 5-year period, 70% of the 905 participants (n = 631) had no tachysystole, 143 had 1 or 2 episodes whereas 131 or 15% had ≥3 episodes (p = 0...
November 5, 2016: Gynecologic and Obstetric Investigation
Hatice Kansu-Celik, Ozlem Gun-Eryılmaz, Nasuh Utku Dogan, Seval Haktankaçmaz, Mehmet Cinar, Saynur Sarici Yilmaz, Cavidan Gülerman
BACKGROUND: We aimed to evaluate the efficacy and safety of dinoprostone for cervical ripening and labor induction in patients with term oligohydramnios and Bishop score ≤ 5. METHODS: This was a prospective case-control study, which included 104 consecutive women with a Bishop score≤5. Participants were divided into two groups. Women with term isolated oligohydramnios and Bishop score≤5 underwent induction of labor with a vaginal insert containing 10-mg timed-release dinoprostone (prostaglandin E2; Group A, n=40)...
October 10, 2016: Journal of the Chinese Medical Association: JCMA
Eran Hadar, Liran Hiersch, Eran Ashwal, Rony Chen, Arnon Wiznitzer, Rinat Gabbay-Benziv
PURPOSE: Maternal age is an important consideration for antenatal care, labor and delivery. We aimed to evaluate the induction of labor (IoL) failure rates among elderly nulliparous women. MATERIALS AND METHODS: We conducted a retrospective analysis of all nulliparous women at 34 + 0 to 41 + 6 weeks, undergoing cervical ripening by prostaglandin E2 (PGE2) vaginal insert. Study group included elderly (≥35 years) nulliparous and control group included non-elderly (<35 years) nulliparous women...
October 17, 2016: Journal of Maternal-fetal & Neonatal Medicine
Braganza Veena, Rajinish Samal, Leeberk R Inbaraj, Carolin Elizabeth George
BACKGROUND: Prostaglandins are popular agents for induction of labour, owing to their dual action of cervical ripening and inducing uterine contractions. Sublingual misoprostol offers high efficacy as it bypasses first-pass metabolism. Researchers have proved that intracervical PGE1 is as effective as PGE2 except for increased caesarean rate and hyperstimulation. Limited knowledge is available on the efficacy of sublingual PGE1 and intracervical PGE2. This study was designed to compare the effectiveness of sublingual PGE1 with intracervical PGE2...
October 2016: Journal of Obstetrics and Gynaecology of India
Chanderdeep Sharma, Anjali Soni, Pawan K Soni, Suresh Verma, Ashok Verma, Amit Gupta
OBJECTIVE: To investigate the role of "mifepristone" for induction of labor (IOL) in pregnant women with prior cesarean section (CS). METHODS: In this retrospective study, all pregnant women with prior CS who received oral mifepristone (400 mg) for IOL (as per clear obstetric indications) [group 1] were compared with pregnant women with prior CS who had spontaneous onset of labor (SOL) [group 2], with respect to incidence of vaginal delivery, CS, duration of labor, and various maternal and fetal outcomes...
October 2016: Journal of Obstetrics and Gynaecology of India
Sven Kehl, Lena Böhm, Christel Weiss, Jutta Heimrich, Ulf Dammer, Friederike Baier, Marc Sütterlin, Matthias W Beckmann, Florian Faschingbauer
AIM: The best time to commence cervical ripening with a balloon catheter is unknown. The aim of this study was to evaluate whether application of a balloon catheter in the morning or in the evening is better when sequential prostaglandin application is planned. METHODS: This multicenter historical cohort study included 415 women with an unfavorable cervix undergoing labor induction at term. Labor was induced with a double-balloon catheter and the sequential use of oral misoprostol if necessary...
September 19, 2016: Journal of Obstetrics and Gynaecology Research
Gary Fruhman, Jeffrey A Gavard, Erol Amon, Kathleen V G Flick, Collin Miller, Gilad A Gross
BACKGROUND: Cervical ripening of an unfavorable cervix can be achieved by placement of a transcervical catheter. Advantages of this method include both lower cost and lower risk of tachysystole than other methods. Despite widespread use with varying degrees of applied tension, an unanswered question is whether there is an advantage to placing the transcervical catheter to tension compared with placement without tension. OBJECTIVE: The purpose of this study was to determine whether tension placed on a transcervical balloon catheter that is inserted for cervical ripening results in a faster time to delivery...
September 15, 2016: American Journal of Obstetrics and Gynecology
Aya Mohr-Sasson, Eyal Schiff, Ofra Sindel, Ramy Rahamim Suday, Anat Kalter-Farber, Roy Mashiach, Yoav Yinon, Moti Dulitzki, Eyal Sivan, Shali Mazaki-Tovi
PURPOSE: To determine the success rate of induction of labor (IOL) using Foley transcervical balloon (FTB) versus prostaglandin E2 (PGE2) vaginal insert, following failure of cervical ripening with PGE2 vaginal insert. MATERIALS AND METHODS: A retrospective cohort study of all pregnant women admitted for IOL with either FTB or PGE2 vaginal insert. Either second dose of PGE2 vaginal insert or FTB was used as a second line treatment after failure (not giving birth in 24 h from insertion) of first PGE2 vaginal insert...
October 6, 2016: Journal of Maternal-fetal & Neonatal Medicine
Gerson Weiss, Sam Teichman, Dennis Stewart, David Nader, Susan Wood, Peter Breining, Elaine Unemori
BACKGROUND: Nonclinical studies indicate that the hormone relaxin is a good candidate for a safe cervical ripening agent that does not cause uterine contractions. METHODS: This Phase II study (conducted November 2, 2005-October 20, 2006) was a randomised, double blind, placebo controlled trial testing 24-h intravenous infusion of serelaxin (recombinant human relaxin) or placebo for cervical ripening in 72 healthy, primiparous women. Eligible subjects had a singleton pregnancy ≥40 weeks, were planned for elective induction, had vertex presentation of the fetus, intact membranes and a Bishop score at screening ≤4...
2016: BMC Pregnancy and Childbirth
Nadia Ouerdiane, Nihel Tlili, Kaouther Othmani, Walid Daaloul, Abdelwaheb Masmoudi, Sonia Ben Hamouda, Badreddine Bouguerra
To evaluate the efficacy and safety of vaginal misoprostol for term labour induction. A prospective study conducted at the Department of Obstetrics and Gynecology B of hospital Charles Nicolle, Tunis, over a period of 4 months. The group of subjects, selected to represent the population of interest, were pregnant patients at term undergoing cervical ripening. Patients received 50 mcg vaginal misoprostol every 12 hours. The parameters studied were: contractile abnormalities, abnormalities of fetal heart rate (FHR), mode of delivery, delayed delivery and neonatal status...
2016: Pan African Medical Journal
Lindsay Beckwith, Kristin Magner, Sara Kritzer, Carri R Warshak
PURPOSE: Assess the impact of obesity on successful cervical ripening with mechanical versus prostaglandin ripening. MATERIALS AND METHODS: We compared obese to non-obese women in an analysis stratified by induction method, prostaglandin versus mechanical. Misoprostol dosing was the same for obese and non-obese women. Pitocin was titrated to effect. Our primary outcome was failure to achieve active labor. Secondary outcomes included overall cesarean delivery rate, doses of misoprostol used and need for protocol deviation...
August 25, 2016: Journal of Maternal-fetal & Neonatal Medicine
Ibrahim Garba, Abubakar Shehu Muhammed, Zakari Muhammad, Hadiza Shehu Galadanci, Rabiu Ayyuba, Idris Sulaiman Abubakar
BACKGROUND: Induction of labor (IOL) is an artificial initiation of labor before its spontaneous onset for the purpose of delivery of the fetoplacental unit. Many factors are associated with its success in postdatism. OBJECTIVE: To compare the induction delivery intervals using transcervical Foley catheter plus oxytocin and vaginal misoprostol, and to identify the factors associated with successful induction among postdate singleton multiparae. MATERIALS AND METHODS: The study was a prospective randomized controlled trial of singleton multiparous pregnant women...
July 2016: Annals of African Medicine
Y M Du, L Y Zhu, L N Cui, B H Jin, J L Ou
BACKGROUND: Induction of labour has become an increasingly common procedure. Ripening methods, including mechanical devices and pharmacological agents, improve the success rate of labour induction. OBJECTIVE: To compare the efficacy and safety of the double-balloon catheter with prostaglandin E2 agents used for labour induction. SEARCH STRATEGY: We searched electronic sources from MEDLINE, Embase and Web of Science, the Cochrane Library Database of Systematic Reviews, and ClinicalTrials...
August 17, 2016: BJOG: An International Journal of Obstetrics and Gynaecology
Adel M Nada, Ahmed R Elzayat, Mohamed H Awad, Ahmed A Metwally, Ayman M Taher, Asmaa I Ogila, Ahmed N Askalany, Reham A Mohsen, Mona Mostafa, Hoda Abdelaal
STUDY OBJECTIVE: To evaluate whether misoprostol oral is as effective as vaginal tablets for cervical ripening. DESIGN: Randomized controlled trial involving a parallel, double-blinded study (Canadian Task Force Classification IB). SETTING: Department of Obstetrics and Gynecology, Cairo University Hospital, between January 2014 and January 2016. PATIENTS: Patients undergoing operative hysteroscopy for various indications...
August 11, 2016: Journal of Minimally Invasive Gynecology
Sven Kehl, Christel Weiss, Werner Rath
To systematically review the application of balloon catheters for cervical ripening and labor induction at term after previous cesarean section. All pregnancies at term with previous cesarean section were included when cervical ripening or labor induction was conducted with balloon catheters. MEDLINE, Cochrane database and bibliography of identified articles were searched for English language studies. Reviews and meta-analysis, randomized and non-randomized controlled trials, prospective and retrospective cohort studies as well as case-control studies were considered...
September 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Andrew N Sharp, Sarah J Stock, Zarko Alfirevic
OBJECTIVE: To identify the current UK use of outpatient procedures for cervical ripening prior to induction of labour. STUDY DESIGN: Postal survey of consultant led obstetric units within the United Kingdom. A questionnaire was sent by post to 210 NHS consultant led obstetric units within the UK. Units that provided outpatient induction of labour (OP IOL) were asked complete a series of questions defining their protocol for risk stratification and management. RESULTS: The survey had a 78% response rate...
September 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Ashley N Battarbee, Anna Palatnik, Danielle A Peress, William A Grobman
OBJECTIVE: To evaluate the association between early amniotomy after ripening with a Foley balloon catheter and duration of labor induction. METHODS: In this retrospective matched cohort study, 546 nulliparous women with a singleton viable gestation undergoing cervical ripening with a Foley balloon catheter were compared based on timing of amniotomy after catheter removal: early (defined as artificial rupture of membranes less than 1 hour after Foley removal) compared with no artificial rupture of membranes in the first hour...
September 2016: Obstetrics and Gynecology
Panagiotis Drakopoulos, Céline Duyck, Angèle Gayet-Ageron, Sonia Fernandez, Olivier Irion, Begoña Martinez de Tejada
OBJECTIVES: To evaluate the number of misoprostol tablets needed to obtain a Bishop score (BS) ≥ 6 or a significant cervical change (≥2 points in BS) during cervical ripening. METHODS: Retrospective study of women with term singleton pregnancies and a BS < 6 taking oral misoprostol (20 μg first 2 doses followed by 40 μg every 2 h) for cervical ripening. RESULTS: We included 400 women, 72% nulliparous, mean age of 31.3 ± 5.9 years and 70% with a baseline BS ≤ 2...
August 4, 2016: Journal of Maternal-fetal & Neonatal Medicine
Larisa Mešić Ðogić, Dragana Mićić, Feđa Omeragić, Refka Kovač, Seid Fazlagić
Aim To establish a correlation between positive values of IGFBP-1(>10 mg/L, Actim Partus Test, APT) and premature cervical ripening in imminent preterm labor. Methods A prospective study was conducted in primary health care centers in Tuzla, Gynecology and Obstetrics Clinic of the University Clinical Centre in Tuzla and General Hospital Tešanj. The study included 50 women (singleton pregnancy, 28-37 week) with imminent preterm labor diagnosed by cervical biometry and modified Bishop score) (examinees) and 30 healthy pregnant women (control group)...
August 1, 2016: Medicinski Glasnik
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