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https://www.readbyqxmd.com/read/28076940/cervical-ripening-with-self-administered-iso-sorbide-mononitrate-vaginally-in-uncomplicated-singleton-pregnancies-at-39-weeks-gestation-a-double-blind-randomised-controlled-trial
#1
RANDOMIZED CONTROLLED TRIAL
K Attanayake, M Goonewardene
Introduction: Vaginal iso sorbide mononitrate (ISMN) is effective in pre induction cervical ripening in post dated pregnancies. Objectives: To determine the effectiveness and acceptability of ISMN self-administered vaginally at home, in causing cervical ripening in uncomplicated singleton pregnancies at 39 weeks gestation. Methods: Consecutive women with uncomplicated singleton pregnancies, presenting between 01 October 2013 and 31 March 2014, with a modified Bishop score (MBS) of < 5 at a gestational age (GA) of 273 days to the University Obstetric Unit of Teaching Hospital Mahamodera Galle, were allocated by stratified (primip/multip) block randomisation to self-administer vaginally at home every other day, five doses of 60 mg of sustained release form of ISMN (ISMN-SR); (n = 72, cases), or pyridoxine 10 mgs (n=72, controls), from GA 273 to 282 days...
30, 2016: Ceylon Medical Journal
https://www.readbyqxmd.com/read/28074548/annual-report-of-the-perinatology-committee-japan-society-of-obstetrics-and-gynecology-2015-proposal-of-urgent-measures-to-reduce-maternal-deaths
#2
Satoru Takeda, Jun Takeda, Keisuke Murakami, Takahiko Kubo, Hiromi Hamada, Maki Murakami, Shintaro Makino, Hiroaki Itoh, Takashi Ohba, Katsuhiko Naruse, Hiroaki Tanaka, Naohiro Kanayama, Shigeki Matsubara, Hiroshi Sameshima, Tomoaki Ikeda
Perinatal care in Japan has progressed rapidly in recent decades, remarkably reducing maternal, perinatal and neonatal mortality rates. This is attributable not only to the sustained efforts and dedication of past obstetricians and midwives, but also to the collective results achieved by the Japan Society of Obstetrics and Gynecology and healthcare administration, including research on advanced medical care, education, medical care improvements and establishing perinatal care centers. Although the maternal mortality rate was in steady decline until 2007 (3...
January 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28061767/the-effect-of-induction-method-in-twin-pregnancies-a-secondary-analysis-for-the-twin-birth-study
#3
Elad Mei-Dan, Elizabeth V Asztalos, Andrew R Willan, Jon F R Barrett
BACKGROUND: This secondary analysis for the Twin Birth Study, an international, multicenter trial, aimed to compare the cesarean section rates and safety between methods of induction of labor in twin pregnancies. METHODS: Women with twin pregnancies where the first twin was in a cephalic presentation and who presented for labor induction, were non-randomly assigned to receive prostaglandin or amniotomy and/or oxytocin. Main outcome measures were the rates of unplanned cesarean section and neonatal and maternal mortality or serious morbidity...
January 6, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28002621/acupuncture-and-acupressure-in-labor
#4
REVIEW
Judith M Schlaeger, Elizabeth M Gabzdyl, Jeanie L Bussell, Nobuari Takakura, Hiroyoshi Yajima, Miho Takayama, Diana J Wilkie
Acupuncture and acupressure, 2 modalities of Traditional Chinese Medicine, are based on reducing pain and symptoms of disease through balancing yin and yang. Acupuncture and acupressure have been used in China for reduction of labor pain, labor augmentation, and other intrapartum indications for more than 2 millennia. This article presents a review of the current literature that has addressed the effects of acupuncture and acupressure on intrapartum events. Studies of acupuncture have demonstrated that acupuncture may reduce labor pain, the use of pharmacologic agents, the use of forceps and vacuum-assisted births, and the length of labor...
December 21, 2016: Journal of Midwifery & Women's Health
https://www.readbyqxmd.com/read/27988062/review-eicosanoids-in-preterm-labor-and-delivery-potential-roles-of-exosomes-in-eicosanoid-functions
#5
REVIEW
H N Peiris, K Vaswani, F Almughlliq, Y Q Koh, M D Mitchell
Preterm delivery is a major obstetric health problem contributing to poor neonatal outcome including low birth weight, respiratory distress syndrome, gastrointestinal, immunologic, central nervous system, hearing, and vision problems. Worldwide, approximately 15 million babies are born prematurely each year. The critical question which remains is how to identify women destined to deliver preterm from those who will achieve a term delivery. Prostaglandins, in all mammals are important in the parturient process...
December 9, 2016: Placenta
https://www.readbyqxmd.com/read/27981257/assessing-the-efficacy-of-vaginal-hyoscine-butyl-bromide-on-cervical-ripening-prior-to-intrauterine-procedures-a-double-blinded-clinical-trial
#6
Shiva Hadadian, Masoumeh Fallahian
BACKGROUND: Unripe cervix prevents entering the endometrial cavity during intrauterine procedures. Mechanical dilatation of cervical canal might cause undesirable complications. OBJECTIVE: To investigate the substitute of mechanical intervention with chemical treatment by administering hyoscine to patients. MATERIALS AND METHODS: Sixty non-pregnant women, 20-70 years of age, with a closed cervix who were scheduled for an intrauterine procedure, were randomly divided into two groups...
November 2016: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/27977408/use-of-translabial-three-dimensional-power-doppler-ultrasound-for-cervical-assessment-before-labor-induction
#7
Sertac Esin, Bulent Yirci, Serdar Yalvac, Omer Kandemir
OBJECTIVE: To compare translabial three-dimensional (3D) power Doppler ultrasound with Bishop score and transvaginal ultrasound measurements for cervical assessment before induction of labor with dinoprostone or cervical ripening balloon. MATERIALS AND METHODS: Translabial cervical volume and length, vascularization indices and transvaginal cervical length were measured. Results were compared among women who had vaginal delivery at 24 h or less and more than 24 h after the insertion of the dinoprostone vaginal insert or cervical ripening balloon and among women who had vaginal delivery and cesarean delivery for failure to go into labor or failure to progress...
December 15, 2016: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/27936988/effect-of-fetal-gender-on-induction-of-labor-failure-rates
#8
Eran Ashwal, Eran Hadar, Rony Chen, Amir Aviram, Liran Hiersch, Rinat Gabbay-Benziv
PURPOSE: To evaluate gender effect on induction of labor (IoL) failure rates stratified by indication to delivery. METHODS: Retrospective cohort analysis of singleton pregnancies 34-42 weeks undergoing cervical ripening using controlled-release PGE2 vaginal insert. IoL Indications were divided to: (1) maternal; (2) hypertensive disorders; (3) premature rupture of membrane or (4) fetal (growth abnormalities, oligohydramnios, postdate etc). IoL failure was defined as: (1) Bishop-score ≤7 24 hours after PGE2; (2) cesarean delivery due to failed induction; (3) fetal distress followed by PGE2 removal and emergent cesarean...
December 11, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27928864/vaginal-misoprostol-and-cervical-ripening-balloon-for-induction-of-labor-in-late-term-pregnancies
#9
Jorge Duro Gómez, María Fernanda Garrido Oyarzún, Ana Belén Rodríguez Marín, Antonio Jesús de la Torre González, José Eduardo Arjona Berral, Camil Castelo-Branco
AIM: The aim of this study was to compare vaginal misoprostol with the Cook cervical ripening balloon (CCRB) for induction of labor in late-term nulliparous women. METHODS: This open, quasi-experimental, prospective study included 109 nulliparous women with late-term pregnancies and Bishop scores < 7. Fifty-five women were allocated to receive vaginal misoprostol 25 mcg and 54 received the CCRB to induce labor. The primary outcome was the time until delivery...
December 8, 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/27928676/can-we-predict-successful-cervical-ripening-with-prostaglandin-e2-vaginal-inserts
#10
Liran Hiersch, Adi Borovich, Rinat Gabbay-Benziv, Moria Maimon-Cohen, Amir Aviram, Yariv Yogev, Eran Ashwal
PURPOSE: Previous studies have suggested that a variety of maternal and obstetrical characteristics may predict successful prostaglandin E2 (PGE2) cervical ripening. However, in most studies women were administered vaginal tablets or gel so scarce is known regarding potential predictors in women administrated slow-release vaginal inserts. We aimed to characterize the response of cervical ripening for labor induction using slow-release PGE2 vaginal insert and to identify predictors for success...
December 7, 2016: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/27918616/nitric-oxide-donors-for-cervical-ripening-and-induction-of-labour
#11
REVIEW
Arpita Ghosh, Katherine R Lattey, Anthony J Kelly
BACKGROUND: Sometimes it is necessary to bring on labour artificially because of safety concerns for the mother or baby. This review is one of a series of reviews of methods of labour induction using a standardised protocol. OBJECTIVES: To determine the effects of NO donors (isosorbide mononitrate (ISMN), isosorbide dinitrate (ISDN), nitroglycerin and sodium nitroprusside) for third trimester cervical ripening or induction of labour, in comparison with placebo or no treatment or other treatments from a predefined hierarchy...
5, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27816973/tachysystole-following-cervical-ripening-and-induction-of-labor-is-not-associated-with-adverse-outcomes
#12
James A Bofill, Marie M Darby, Javier Castillo, Sandip U Sawardecker, Everett F Magann, John C Morrison
PURPOSE: This study was aimed at determining if significant uterine tachysystole was associated with adverse fetal or neonatal outcomes during cervical ripening and induction of labor. METHODS: Women undergoing cervical ripening and subsequent labor induction (n = 905) were assessed for tachysystole, defined as ≥6 contractions in each of 2 consecutive 10-minute windows. Women with ≥3 episodes of tachysystole were compared to women with no tachysystole. RESULTS: Over a 5-year period, 70% of the 905 participants (n = 631) had no tachysystole, 143 had 1 or 2 episodes whereas 131 or 15% had ≥3 episodes (p = 0...
November 5, 2016: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/27745800/prostaglandin-e2-induction-of-labor-and-cervical-ripening-for-term-isolated-oligohydramnios-in-pregnant-women-with-bishop-score%C3%A2-%C3%A2-%C3%A2-5
#13
Hatice Kansu-Celik, Ozlem Gun-Eryılmaz, Nasuh Utku Dogan, Seval Haktankaçmaz, Mehmet Cinar, Saynur Sarici Yilmaz, Cavidan Gülerman
BACKGROUND: We aimed to evaluate the efficacy and safety of dinoprostone for cervical ripening and labor induction in patients with term oligohydramnios and Bishop score ≤ 5. METHODS: This was a prospective case-control study, which included 104 consecutive women with a Bishop score≤5. Participants were divided into two groups. Women with term isolated oligohydramnios and Bishop score≤5 underwent induction of labor with a vaginal insert containing 10-mg timed-release dinoprostone (prostaglandin E2; Group A, n=40)...
October 10, 2016: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/27677204/induction-of-labor-in-elderly-nulliparous-women
#14
Eran Hadar, Liran Hiersch, Eran Ashwal, Rony Chen, Arnon Wiznitzer, Rinat Gabbay-Benziv
PURPOSE: Maternal age is an important consideration for antenatal care, labor and delivery. We aimed to evaluate the induction of labor (IoL) failure rates among elderly nulliparous women. MATERIALS AND METHODS: We conducted a retrospective analysis of all nulliparous women at 34 + 0 to 41 + 6 weeks, undergoing cervical ripening by prostaglandin E2 (PGE2) vaginal insert. Study group included elderly (≥35 years) nulliparous and control group included non-elderly (<35 years) nulliparous women...
October 17, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27651590/sublingual-misoprostol-pge1-versus-intracervical-dinoprostone-pge2-gel-for-induction-of-labour-a-randomized-control-trail
#15
Braganza Veena, Rajinish Samal, Leeberk R Inbaraj, Carolin Elizabeth George
BACKGROUND: Prostaglandins are popular agents for induction of labour, owing to their dual action of cervical ripening and inducing uterine contractions. Sublingual misoprostol offers high efficacy as it bypasses first-pass metabolism. Researchers have proved that intracervical PGE1 is as effective as PGE2 except for increased caesarean rate and hyperstimulation. Limited knowledge is available on the efficacy of sublingual PGE1 and intracervical PGE2. This study was designed to compare the effectiveness of sublingual PGE1 with intracervical PGE2...
October 2016: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/27651574/a-retrospective-case-control-study-evaluating-the-role-of-mifepristone-for-induction-of-labor-in-women-with-previous-cesarean-section
#16
Chanderdeep Sharma, Anjali Soni, Pawan K Soni, Suresh Verma, Ashok Verma, Amit Gupta
OBJECTIVE: To investigate the role of "mifepristone" for induction of labor (IOL) in pregnant women with prior cesarean section (CS). METHODS: In this retrospective study, all pregnant women with prior CS who received oral mifepristone (400 mg) for IOL (as per clear obstetric indications) [group 1] were compared with pregnant women with prior CS who had spontaneous onset of labor (SOL) [group 2], with respect to incidence of vaginal delivery, CS, duration of labor, and various maternal and fetal outcomes...
October 2016: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/27642010/timing-of-sequential-use-of-double-balloon-catheter-and-oral-misoprostol-for-induction-of-labor
#17
Sven Kehl, Lena Böhm, Christel Weiss, Jutta Heimrich, Ulf Dammer, Friederike Baier, Marc Sütterlin, Matthias W Beckmann, Florian Faschingbauer
AIM: The best time to commence cervical ripening with a balloon catheter is unknown. The aim of this study was to evaluate whether application of a balloon catheter in the morning or in the evening is better when sequential prostaglandin application is planned. METHODS: This multicenter historical cohort study included 415 women with an unfavorable cervix undergoing labor induction at term. Labor was induced with a double-balloon catheter and the sequential use of oral misoprostol if necessary...
November 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/27640940/tension-compared-to-no-tension-on-a-foley-transcervical-catheter-for-cervical-ripening-a-randomized-controlled-trial
#18
Gary Fruhman, Jeffrey A Gavard, Erol Amon, Kathleen V G Flick, Collin Miller, Gilad A Gross
BACKGROUND: Cervical ripening of an unfavorable cervix can be achieved by placement of a transcervical catheter. Advantages of this method include both lower cost and lower risk of tachysystole than other methods. Despite widespread use with varying degrees of applied tension, an unanswered question is whether there is an advantage to placing the transcervical catheter to tension compared with placement without tension. OBJECTIVE: The purpose of this study was to determine whether tension placed on a transcervical balloon catheter that is inserted for cervical ripening results in a faster time to delivery...
January 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27633399/second-dose-of-pge2-vaginal-insert-versus-foley-transcervical-balloon-for-induction-of-labor-after-failure-of-cervical-ripening-with-pge2-vaginal-insert
#19
Aya Mohr-Sasson, Eyal Schiff, Ofra Sindel, Ramy Rahamim Suday, Anat Kalter-Farber, Roy Mashiach, Yoav Yinon, Moti Dulitzki, Eyal Sivan, Shali Mazaki-Tovi
PURPOSE: To determine the success rate of induction of labor (IOL) using Foley transcervical balloon (FTB) versus prostaglandin E2 (PGE2) vaginal insert, following failure of cervical ripening with PGE2 vaginal insert. MATERIALS AND METHODS: A retrospective cohort study of all pregnant women admitted for IOL with either FTB or PGE2 vaginal insert. Either second dose of PGE2 vaginal insert or FTB was used as a second line treatment after failure (not giving birth in 24 h from insertion) of first PGE2 vaginal insert...
October 6, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27596360/recombinant-human-relaxin-versus-placebo-for-cervical-ripening-a-double-blind-randomised-trial-in-pregnant-women-scheduled-for-induction-of-labour
#20
Gerson Weiss, Sam Teichman, Dennis Stewart, David Nader, Susan Wood, Peter Breining, Elaine Unemori
BACKGROUND: Nonclinical studies indicate that the hormone relaxin is a good candidate for a safe cervical ripening agent that does not cause uterine contractions. METHODS: This Phase II study (conducted November 2, 2005-October 20, 2006) was a randomised, double blind, placebo controlled trial testing 24-h intravenous infusion of serelaxin (recombinant human relaxin) or placebo for cervical ripening in 72 healthy, primiparous women. Eligible subjects had a singleton pregnancy ≥40 weeks, were planned for elective induction, had vertex presentation of the fetus, intact membranes and a Bishop score at screening ≤4...
September 5, 2016: BMC Pregnancy and Childbirth
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