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Type II Diabetes

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https://www.readbyqxmd.com/read/29791782/obesity-leads-to-impairments-in-the-morphology-and-organization-of-human-skeletal-muscle-lipid-droplets-and-mitochondrial-networks-which-are-resolved-with-gastric-bypass-surgery-induced-improvements-in-insulin-sensitivity
#1
Marianne D Kristensen, Signe M Petersen, Kjestine E Møller, Michael T Lund, Merethe Hansen, Christina N Hansen, Julie Courraud, Jørn W Helge, Flemming Dela, Clara Prats
AIMS: Skeletal muscle lipid stores and mitochondrial function have been appointed as key players in obesity-induced insulin resistance. However, there are conflicting reports in the literature based on in vitro quantitative measurements. Here we test the hypothesis that it is not the quantity but the quality that matters. METHODS: The present study combines quantitative and qualitative structural measurements of lipid stores and mitochondrial dynamics in skeletal muscle from lean subjects, and subjects with morbid obesity, with and without type 2 diabetes, before and after gastric bypass surgery...
May 23, 2018: Acta Physiologica
https://www.readbyqxmd.com/read/29791638/assessment-of-ulceration-risk-in-diabetic-individuals
#2
Luz Marina Alfonso Dutra, Maria Rita Carvalho Garbi Novaes, Manuela Costa Melo, Danyelle Lorrane Carneiro Veloso, Dayane Leticia Faustino, Leila Maria Sales Sousa
OBJECTIVE: To identify the risk factors for foot ulceration through the tracing of diabetic peripheral neuropathy and peripheral arterial disease in individuals with type I and II diabetes, who were assisted in reference centers of the Federal District, Brazil. METHOD: a cross-sectional and analytical study, with the assessment of 117 individuals in outpatient clinics of the Federal District. Continuous variables were compared through Mann-Whitney test, and categorized variables, through Chi-square test for univariate analysis and Logistics regression test for multivariate analysis...
2018: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/29790775/dental-periodontal-and-salivary-conditions-in-diabetic-children-associated-with-metabolic-control-variables-and-nutritional-plan-adherence
#3
C Y Díaz Rosas, E Cárdenas Vargas, J E Castañeda-Delgado, L A Aguilera-Galaviz, M C Aceves Medina
AIM: Diabetes mellitus is a chronic disease that has manifestations other than alterations in endocrine regulation or in metabolic pathways. Several diseases of the oral cavity have been associated with diabetes mellitus type 1 and 2 in young people according to their evolution. Scarce information exists regarding the role of diabetes and its association with the oral health status in paediatric diabetic patients. The aims of the study were to assess the quality of saliva, saliva acidogenicity, dental caries experience, fluorosis and periodontal status in diabetic patients and to evaluate their relationship with metabolic control variables and nutritional plan adherence...
June 2018: European Journal of Paediatric Dentistry: Official Journal of European Academy of Paediatric Dentistry
https://www.readbyqxmd.com/read/29789207/antidiabetic-potential-of-phytochemicals-isolated-from-the-stem-bark-of-myristica-fatua-houtt-var-magnifica-bedd-sinclair
#4
B Prabha, S Neethu, S Lekshmy Krishnan, D R Sherin, M Madhukrishnan, R Ananthakrishnan, K B Rameshkumar, T K Manojkumar, P Jayamurthy, K V Radhakrishnan
Phytochemical investigation of the stem bark of Myristica fatua Houtt. led to the isolation of a new compound 1 (3-tridecanoylbenzoic acid), along with six known acylphenols (2-7). All the compounds displayed moderate inhibitory activity on α-amylase and significant activity on α-glucosidase; however malabaricone B (6) and C (7) were identified as potent α-glucosidase inhibitors with IC50 values of 63.70 ± 0.546, and 43.61 ± 0.620 µM respectively. Acylphenols (compounds 3-7) also showed significant antiglycation property...
May 19, 2018: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29789130/the-effects-of-alcohol-on-plasma-lipid-mediators-of-inflammation-resolution-in-patients-with-type-2-diabetes-mellitus
#5
Anne Barden, Sujata Shinde, Michael Phillips, Lawrence Beilin, Emilie Mas, Jonathan M Hodgson, Ian Puddey, Trevor A Mori
BACKGROUND: Type 2 diabetes mellitus is characterized by peripheral insulin resistance and low-grade systemic inflammation. Inflammation resolution is recognised as an important process driven by specialised pro-resolving mediators of inflammation (SPMs) and has the potential to moderate chronic inflammation. Alcohol has the potential to affect synthesis of SPMs by altering key enzymes involved in SPM synthesis and may influence ongoing inflammation associated with Type 2 diabetes mellitus...
June 2018: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/29788884/progress-of-oral-insulin-and-related-drug-delivery-systems-and-their-pharmacokinetics
#6
Jingjing Chen, Rui Liu, Changxiao Liu, Xin Jin, Qinghua Zhang, Jialu Wang, Fang Zhao, Ze Wang, Haiyan Qiu, Yazhuo Li, Xiulin Yi
BACKGROUND: As society has developed and living standards have improved, diabetes has become a severe public health issue. Insulin plays a crucial role in managing hyperglycemia caused by type I diabetes and particular type II diabetes. Many researchers are seeking alternative, more acceptable methods of insulin delivery, such as oral insulin. An oral formulation has become a new goal for insulin delivery in recent years. METHODS: The PubMed and CNKI databases were searched for "oral insulin, " "drug delivery systems, " and "pharmacokinetics, " and 85 relevant articles were selected from the results as material for this review...
May 22, 2018: Current Drug Metabolism
https://www.readbyqxmd.com/read/29788881/novel-solid-lipid-nanocarrier-of-glibenclamide-a-factorial-design-approach-with-response-surface-methodology
#7
Sonia Pandey, Payal Patel, Arti Gupta
BACKGROUND: In the present investigation a factorial design approach attempt was applied to develop the solid lipid nanoparticles (SLN) of Glibenclamide (GLB) a poorly water-soluble drug (BCS -II) used in the treatment of type 2 diabetes. OBJECTIVES: Prime objectives of this experiment are to optimize the SLN formulation of Glibenclamide and improve the therapeutic effectiveness of the developed formulation. METHODS: Glibenclamide loaded SLNs (GLB-SLN) were fabricated by High speed homogenization technique...
May 21, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29786669/protein-tyrosine-phosphatase-1b-inhibition-and-glucose-uptake-potentials-of-mulberrofuran-g-albanol-b-and-kuwanon-g-from-root-bark-of-morus-alba-l-in-insulin-resistant-hepg2-cells-an-in-vitro-and-in-silico-study
#8
Pradeep Paudel, Ting Yu, Su Hui Seong, Eun Bi Kuk, Hyun Ah Jung, Jae Sue Choi
Type II diabetes mellitus (T2DM) is the most common form of diabetes and has become a major health problem across the world. The root bark of Morus alba L. is widely used in Traditional Chinese Medicine for treatment and management of diabetes. The aim of the present study was to evaluate the enzyme inhibitory potentials of three principle components, mulberrofuran G ( 1 ), albanol B ( 2 ), and kuwanon G ( 3 ) in M. alba root bark against diabetes, establish their enzyme kinetics, carry out a molecular docking simulation, and demonstrate the glucose uptake activity in insulin-resistant HepG2 cells...
May 22, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29781744/endurance-training-alters-ykl40-perm1-and-hsp70-skeletal-muscle-protein-contents-in-men-with-type-2-diabetes-mellitus
#9
Christian Brinkmann, Anika Kuckertz, Thorsten Schiffer, Wilhelm Bloch, Hans-Georg Predel, Klara Brixius
BACKGROUND: The fight against type 2 diabetes mellitus (T2DM) is tremendously challenging. This pilot study investigates whether endurance training (3 times per week for 3 months, moderate intensity) can change the skeletal muscle protein contents of chitinase-3-like protein-1 (YKL40), peroxisome proliferator-activated receptor y coactivator-1 and estrogen-related receptor-induced regulator in muscle-1 (PERM1) and heat-shock protein-70 (HSP70), which have been discussed as novel therapeutically relevant targets...
May 21, 2018: Endocrine Research
https://www.readbyqxmd.com/read/29781721/current-prescription-status-of-antihypertensive-drugs-in-japanese-patients-with-hypertension-analysis-by-type-of-comorbidities
#10
Takayuki Ishida, Akinori Oh, Shinzo Hiroi, Yukio Shimasaki, Takuya Tsuchihashi
In 2014, the Japanese Society of Hypertension (JSH) issued revised guidelines for hypertension management. To assess adherence to the guidelines, this retrospective study evaluated the real-world status of antihypertensive drug prescribing for Japanese patients with hypertension, classified by comorbidity: diabetes mellitus, dyslipidemia, gout/hyperuricemia and renal diseases. Data on 59,867 hypertensive patients who received their first prescription for antihypertensive therapy between April 2014 and March 2015, were obtained from a medical insurance claims database for hospitals participating in the Diagnosis Procedure Combination/Per-Diem payment system...
May 21, 2018: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29780857/multi-omic-network-based-interrogation-of-rat-liver-metabolism-following-gastric-bypass-surgery-featuring-swath-proteomics
#11
Gautham Vivek Sridharan, Matthew D'Alessandro, Shyam Sundhar Bale, Vicky Bhagat, Hugo Gagnon, John M Asara, Korkut Uygun, Martin L Yarmush, Nima Saeidi
Morbidly obese patients often elect for Roux-en-Y gastric bypass (RYGB), a form of bariatric surgery that triggers a remarkable 30% reduction in excess body weight and reversal of insulin resistance for those who are type II diabetic. A more complete understanding of the underlying molecular mechanisms that drive the complex metabolic reprogramming post-RYGB could lead to innovative non-invasive therapeutics that mimic the beneficial effects of the surgery, namely weight loss, achievement of glycemic control, or reversal of non-alcoholic steatohepatitis (NASH)...
September 2017: Technology
https://www.readbyqxmd.com/read/29777849/non-invasive-diagnostic-methods-for-better-screening-of-peripheral-arterial-disease
#12
REVIEW
Neelamshobha Nirala, R Periyasamy, Awanish Kumar
BACKGROUND: Peripheral arterial disease (PAD) is a common circulatory problem in which narrowed arteries reduce blood flow to extremities usually legs. It does not receive enough blood flow to keep up with demand. This causes symptoms, most notably leg pain while walking which is known as claudication. It is a common manifestation of type II Diabetes, but the relationship between other vascular diseases and lower limb (LL)-PAD has been poorly understood and investigated. METHODS: When assessing a patient with clinically LLPAD, two questions are in order to establish a diagnosis: one is non-invasive testing and other is invasive...
May 16, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29774166/hemostatic-state-augmented-with-platelet-indices-among-sudanese-diabetic-septic-foot
#13
Bashir Abdrhman Bashir, Mohamed Salih Ali
Background: Diabetes mellitus is a very rampant metabolic disorder, particularly type II. It has many complications such as the septic foot. Diabetic septic foot (DSF) patients are at high risk for coagulation abnormalities as well as surgical hazards. Owing to the potential sequelae of coagulation and vascular abnormalities, this work aimed at studying the hemostatic state and platelet indices in diabetes type II patients with septic foot. Methods: A case-control study was conducted during the period from July to September 2017 at Dr...
2018: BMC Hematology
https://www.readbyqxmd.com/read/29773555/prostaglandin-f-2%C3%AE-facilitates-hepatic-glucose-production-through-camkii%C3%AE-p38-foxo1-signaling-pathway-in-fasting-and-obesity
#14
Yuanyang Wang, Shuai Yan, Bing Xiao, Shengkai Zuo, Qianqian Zhang, Guilin Chen, Yu Yu, Di Chen, Qian Liu, Yi Liu, Yujun Shen, Ying Yu
Gluconeogenesis is drastically increased in patients with type 2 diabetes and accounts for increased fasting plasma glucose concentrations. Circulating prostaglandin (PG) F2α is also markedly elevated in diabetes mellitus; however, whether and how PGF2α regulates hepatic glucose metabolism remain unknown. Here, we demonstrated that PGF2α receptor (F-prostanoid receptor; FP) was upregulated in livers of mice upon fasting- and diabetic stress. Hepatic deletion of the FP receptor suppressed fasting-induced hepatic gluconeogenesis, whereas FP overexpression enhanced hepatic gluconeogenesis in mice...
May 17, 2018: Diabetes
https://www.readbyqxmd.com/read/29773093/combined-influence-of-insulin-resistance-and-inflammatory-biomarkers-on-type-2-diabetes-a-population-based-prospective-cohort-study-of-inner-mongolians-in-china
#15
Qiao Yan Qiu, Bei Lei Zhang, Ming Zhi Zhang, Jia Hui Wu, Jing Wen Zhou, Zhu Liang, Yong Hong Zhang, Shao Yan Zhang
This prospective study was designed to examine the combined influence of insulin resistance (IR) and inflammatory biomarker levels on type 2 diabetes mellitus (T2DM) among 1,903 Inner Mongolians. During follow-up, 205 (10.77%) participants developed T2DM, and the incidence of T2DM was higher among subjects with IR, elevated C-reactive protein (CRP), elevated sICAM-1, elevated sE-selectin, or the coexistences of IR with elevated CRP, elevated sICAM-1, elevated sE-selectin, and elevated angiotensin II (all P < 0...
April 2018: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29772226/potential-role-of-peroxisome-proliferator-activated-receptor-gamma-activation-on-serum-visfatin-and-trace-elements-in-high-fat-diet-induced-type-2-diabetes-mellitus
#16
Arshia Tabassum, Syeda Nuzhat Fatima Zaidi, Kausar Yasmeen, Tabassum Mahboob
AIMS: Electrolytes and trace elements dysregulation play an important role in the progression of obesity and diabetes complications. The present study was designed to evaluate the insulin sensitizing effects of peroxisomes proliferators activated receptor gamma (PPAR-γ) agonist on trace elements in obesity induced type 2 diabetes mellitus and correlate with serum visfatin. MATERIALS AND METHODS: Wistar rats were categorized into five groups. Group I served as control; Group II fed on high fat diet (HFD); Group III fed on HFD and treated with rosiglitazone (3 mg/kg) for 7 days; Group IV were T2DM rats induce by HFD and low dose of streptozotocin (i...
May 14, 2018: Life Sciences
https://www.readbyqxmd.com/read/29769484/prevalence-of-non-alcoholic-fatty-liver-disease-and-its-biochemical-predictors-in-patients-with-type-2-diabetes-mellitus
#17
M A Kabir, M Z Uddin, N I Siddiqui, I H Robi, M S Malek, M S Islam, S Rahman, M S Hossain, S K Mahapatra, M J Alam, F Ahmad, M S Alam, M A Islam
Non-alcoholic fatty liver disease (NAFLD) is emerging as the most common chronic liver condition in the Western world and it is commonly associated with type 2 diabetes mellitus (DM). The aim of this study to determine the prevalence of NAFLD and identify the predisposing factors in type 2 DM patients with NAFLD. Total of 258 patients of type 2 DM were included in this observational study in the Department of Medicine, Mymensingh Medical College Hospital, Mymensingh, Bangladesh from 11th May 2013 to 11th November 2013...
April 2018: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29769460/circulating-surfactant-protein-d-is-associated-with-clinical-outcomes-in-peripheral-artery-disease-patients-following-endovascular-therapy
#18
Yoichiro Otaki, Tetsu Watanabe, Hiroki Takahashi, Takayuki Sugai, Miyuki Yokoyama, Satoshi Nishiyama, Takanori Arimoto, Tetsuro Shishido, Takuya Miyamoto, Tamon Yamanaka, Isao Kubota, Masafumi Watanabe
BACKGROUND: Peripheral artery disease (PAD) is a risk factor for the development of cardiovascular disease and death. Surfactant protein-D (SP-D) is a 43-kDa protein secreted from type II pneumocytes in the lungs. Recent studies have demonstrated that circulating SP-D plays a key role in the development of atherosclerosis and is related to clinical outcomes in patients with ischemic heart disease. However, it remains unclear whether circulating SP-D is associated with clinical outcomes in patients with PAD...
May 17, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29768449/children-with-type-1-diabetes-who-experienced-a-honeymoon-phase-had-significantly-lower-ldl-cholesterol-5-years-after-diagnosis
#19
Benjamin Udoka Nwosu, Bo Zhang, Sanaa S Ayyoub, Stephanie Choi, Tony R Villalobos-Ortiz, Laura C Alonso, Bruce A Barton
IMPORTANCE: Landmark studies showed that partial clinical remission in new-onset type 1 diabetes is associated with reduced prevalence of long-term complications, but early clinical indicators of this favorable outcome are poorly characterized. AIM: To determine if there were any differences in lipid parameters, especially LDL-cholesterol, between remitters and non-remitters 4 to 5 years after the diagnosis of type 1 diabetes after controlling for hemoglobin A1c, body mass index, and pubertal status...
2018: PloS One
https://www.readbyqxmd.com/read/29767459/long-term-effects-of-patiromer-for-hyperkalaemia-treatment-in-patients-with-mild-heart-failure-and-diabetic-nephropathy-on-angiotensin-converting-enzymes-angiotensin-receptor-blockers-results-from-amethyst-dn
#20
Bertram Pitt, George L Bakris, Matthew R Weir, Mason W Freeman, Mitja Lainscak, Martha R Mayo, Dahlia Garza, Rezi Zawadzki, Lance Berman, David A Bushinsky
AIMS: Chronic kidney disease (CKD) in heart failure (HF) increases the risk of hyperkalaemia (HK), limiting angiotensin-converting enzyme inhibitor (ACE-I) or angiotensin receptor blocker (ARB) use. Patiromer is a sodium-free, non-absorbed potassium binder approved for HK treatment. We retrospectively evaluated patiromer's long-term safety and efficacy in HF patients from AMETHYST-DN. METHODS AND RESULTS: Patients with Type 2 diabetes, CKD, and HK [baseline serum potassium >5...
May 16, 2018: ESC Heart Failure
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