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https://www.readbyqxmd.com/read/27911406/ultrasound-guided-botulinum-toxin-a-injections-a-method-of-treating-sialorrhea
#1
Pierangelo Barbero, Marco Busso, Carlo Alberto Artusi, Stefania De Mercanti, Marco Tinivella, Andrea Veltri, Luca Durelli, Marinella Clerico
Neurological diseases can be complicated by sialorrhea, an excessive flow of saliva. Patients suffering from moderate to severe sialorrhea have an impaired quality of life, often worsened by correlated complications such as aspiration pneumonia, oral infections, dental caries, and maceration of the skin. Diverse therapeutic approaches have been proposed for the treatment of sialorrhea, including surgery and the use of anticholinergic agents, with limited results and the possible occurrence of serious adverse events...
November 9, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27853957/a-guide-to-medications-inducing-salivary-gland-dysfunction-xerostomia-and-subjective-sialorrhea-a-systematic-review-sponsored-by-the-world-workshop-on-oral-medicine-vi
#2
REVIEW
Andy Wolff, Revan Kumar Joshi, Jörgen Ekström, Doron Aframian, Anne Marie Lynge Pedersen, Gordon Proctor, Nagamani Narayana, Alessandro Villa, Ying Wai Sia, Ardita Aliko, Richard McGowan, Alexander Ross Kerr, Siri Beier Jensen, Arjan Vissink, Colin Dawes
BACKGROUND: Medication-induced salivary gland dysfunction (MISGD), xerostomia (sensation of oral dryness), and subjective sialorrhea cause significant morbidity and impair quality of life. However, no evidence-based lists of the medications that cause these disorders exist. OBJECTIVE: Our objective was to compile a list of medications affecting salivary gland function and inducing xerostomia or subjective sialorrhea. DATA SOURCES: Electronic databases were searched for relevant articles published until June 2013...
November 16, 2016: Drugs in R&D
https://www.readbyqxmd.com/read/27846048/scopolamine-ointment-for-clozapine-associated-sialorrhea-a-case-report
#3
Takashi Goto, Miyoko Kato, Yukiko Matsumura, Naoto Omata, Masato Higashima, Yuji Wada, Mari Yoshida, Kyohei Watanabe, Tetsuya Takahashi
No abstract text is available yet for this article.
November 14, 2016: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27816262/sublingual-atropine-in-the-treatment-of-clozapine-induced-sialorrhea
#4
Teofilo E Matos Santana, Noah A Capurso, Mohini Ranganathan, Gihyun Yoon
No abstract text is available yet for this article.
November 2, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27759834/application-of-botulinum-toxin-to-treat-sialorrhea-in-amyotrophic-lateral-sclerosis-patients-a-literature-review
#5
Ademar Francisco de Oliveira, Gêssyca Adryene de Menezes Silva, Débora Milenna Xavier Almeida
Amyotrophic lateral sclerosis is a progressive and fatal neurodegenerative disease characterized by the degeneration of motor neurons, which are the central nervous system cells that control voluntary muscle movements. The excessive salivation (sialorrhea) is present in approximately 50% of amyotrophic lateral sclerosis cases. Thus, some alternative therapeutic methods are sought, such as anticholinergic drugs and surgery. Recently the use of botulinum toxin applied at a midpoint of the salivary glands, often guided by ultrasound, have demonstrated positive results...
July 2016: Einstein
https://www.readbyqxmd.com/read/27759801/unusual-motor-and-non-motor-symptoms-and-signs-in-the-early-stage-of-parkinson-s-disease
#6
Hélio A G Teive, Délcio C Bertucci, Renato P Munhoz
Objective: Patients with Parkinson's disease (PD) may present with unusual motor and non-motor symptoms and signs in the early stage of the disease. Methods: Cases were collected over a five-year period at two tertiary movement disorders clinics. All had a diagnosis of PD with unusual presentations defined retrospectively as the presence of complaints not objectively related to any of the classic cardinal signs of parkinsonism or the typical early non-motor features of PD...
October 2016: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/27674872/unilateral-parotid-radiation-with-electron-beam-for-palliation-of-sialorrhea-in-als-patients-a-prospective-study
#7
B Dhanireddy, E J Kasarskis, M Bruno, C E Wooten, K E Vanderpool, W H St Clair
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27673032/poster-273-botulinum-toxin-injections-to-the-salivary-glands-for-treatment-of-sialorrhea-in-a-patient-with-duchenne-muscular-dystrophy-a-case-report
#8
Jonathan D Carrier, Kristin Caldera
No abstract text is available yet for this article.
September 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/27613712/pathophysiology-underlying-drooling-in-parkinson-s-disease-oropharyngeal-bradykinesia
#9
Mehmet Karakoc, Mehmet Ilker Yon, Gul Yalcin Cakmakli, Ersin Kasim Ulusoy, Aydin Gulunay, Nese Oztekin, Fikri Ak
We aimed to investigate the association between drooling and possible etiological factors in Parkinson's disease (PD) and to determine its effect on the quality of life. Demographic data of the 63 patients with idiopathic PD were recorded. Radboud Oral Motor Inventory for Parkinson's disease (ROMP) test was administered to all patients to evaluate speech, swallowing functions, and saliva control. The freezing of gait questionnaire (FOGQ) was used to evaluate gait and freezing of gait. Dynamic Parkinson gait scale (DYPAGS) was administered for the objective quantification of PD gait features...
December 2016: Neurological Sciences
https://www.readbyqxmd.com/read/27599097/histological-and-immunohistochemical-findings-of-the-action-of-botulinum-toxin-in-salivary-gland-systematic-review
#10
J B Oliveira, J Evêncio-Neto, L Baratella-Evêncio
The treatment of sialorrhea is necessary for the constant risks posed by hypersalivation. A new therapeutic option comes up with the application of botulinum toxin in salivary glands. However, little is known about its mechanism of action in glandular tissue. Based on the above, this work had the objective to systematically review the literature about the action of botulinum toxin on submandibular and parotid salivary glands tissues. Electronic search was performed in databases of great relevance for this study (PubMed, SciELO, HighWire, Crossref, Scopus, Science Direct, MEDLINE, OLDMEDLINE, Serials Database, NLM Catalog, LILACS and IBECS)...
September 5, 2016: Brazilian Journal of Biology, Revista Brasleira de Biologia
https://www.readbyqxmd.com/read/27586238/natural-outbreak-of-bvdv-1d-induced-mucosal-disease-lacking-intestinal-lesions
#11
M V Bianchi, G Konradt, S O de Souza, D M Bassuino, S Silveira, A C S Mósena, C W Canal, S P Pavarini, D Driemeier
Bovine viral diarrhea virus (BVDV) belongs to the Pestivirus genus, which is further divided into subgenotypes (1a-1u and 2a-c). When persistent infection occurs, the calf will be immunotolerant to BVDV and possibly develop mucosal disease. This study describes an outbreak of BVDV-1d-induced mucosal disease lacking intestinal lesions. Eleven calves presented with anorexia, sialorrhea, lameness, recumbency, and death. Three calves were necropsied, showing ulceration of the interdigital skin and the oral and nasal mucosa; linear ulcers in the tongue, esophagus, and rumen; and rounded ulcers in the abomasum...
September 1, 2016: Veterinary Pathology
https://www.readbyqxmd.com/read/27538868/maropitant-administered-orally-2-2-5-h-prior-to-morphine-and-dexmedetomidine-reduces-the-incidence-of-emesis-in-cats
#12
Manuel Martin-Flores, Alicia Mastrocco, Augusto M Lorenzutti, Luis Campoy, Pati Kirch, Marisa Stone, McKenzie M Learn, Jordyn M Boesch
OBJECTIVES: The main goal of this study was to test the antiemetic effects of maropitant administered orally 2-2.5 h prior to morphine and dexmedetomidine in cats. METHODS: Eighty-three healthy female cats were randomized to receive maropitant (8 mg orally; n = 39) or no treatment (control; n = 44), 2-2.5 h prior to morphine 0.1 mg/kg and dexmedetomidine 20 µg/kg intramuscularly. The incidence of sialorrhea, lip licking, retching and vomiting were recorded after morphine/dexmedetomidine injection...
August 18, 2016: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/27526039/progressive-supranuclear-palsy-and-corticobasal-degeneration-pathophysiology-and-treatment-options
#13
REVIEW
Ruth Lamb, Jonathan D Rohrer, Andrew J Lees, Huw R Morris
There are currently no disease-modifying treatments for progressive supranuclear palsy (PSP) or corticobasal degeneration (CBD), and no approved pharmacological or therapeutic treatments that are effective in controlling their symptoms. The use of most pharmacological treatment options are based on experience in other disorders or from non-randomized historical controls, case series, or expert opinion. Levodopa may provide some improvement in symptoms of Parkinsonism (specifically bradykinesia and rigidity) in PSP and CBD; however, evidence is conflicting and where present, benefits are often negligible and short lived...
September 2016: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/27514242/botulinum-toxin-use-in-refractory-pain-and-other-symptoms-in-parkinsonism
#14
Veronica A Bruno, Susan H Fox, Deborah Mancini, Janis M Miyasaki
BACKGROUND: Parkinson's disease (PD) and other parkinsonian syndromes are chronic, progressive neurodegenerative diseases. With advancing disease, both motor and non-motor symptoms represent a considerable burden and symptom relief and quality of life improvement become the main goal of treatment. Botulinum toxins (BTX) are an effective treatment modality for many neurological conditions. METHODS: To understand the potential usefulness of BTX in this population, we performed a retrospective chart review of all patients with a clinical diagnosis of idiopathic PD and atypical parkinsonism who received treatment with BTX injections in our center from 1995 to 2014 for a variety of symptoms...
September 2016: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/27433087/gut-dysfunction-in-parkinson-s-disease
#15
REVIEW
Adreesh Mukherjee, Atanu Biswas, Shyamal Kumar Das
Early involvement of gut is observed in Parkinson's disease (PD) and symptoms such as constipation may precede motor symptoms. α-Synuclein pathology is extensively evident in the gut and appears to follow a rostrocaudal gradient. The gut may act as the starting point of PD pathology with spread toward the central nervous system. This spread of the synuclein pathology raises the possibility of prion-like propagation in PD pathogenesis. Recently, the role of gut microbiota in PD pathogenesis has received attention and some phenotypic correlation has also been shown...
July 7, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27281791/sialorrhea-in-children-with-cerebral-palsy
#16
Bruno Leonardo Scofano Dias, Alexandre Ribeiro Fernandes, Heber de Souza Maia Filho
OBJECTIVE: To review the literature on sialorrhea in children with cerebral palsy. SOURCE OF DATA: Non-systematic review using the keywords "sialorrhea" and "child" carried out in the PubMed(®), LILACS(®), and SciELO(®) databases during July 2015. A total of 458 articles were obtained, of which 158 were analyzed as they were associated with sialorrhea in children; 70 had content related to sialorrhea in cerebral palsy or the assessment and treatment of sialorrhea in other neurological disorders, which were also assessed...
June 6, 2016: Jornal de Pediatria
https://www.readbyqxmd.com/read/27258695/assessment-of-nonmotor-fluctuations-using-a-diary-in-advanced-parkinson-s-disease
#17
Christiana Ossig, Daniel Sippel, Mareike Fauser, Florin Gandor, Wolfgang H Jost, Georg Ebersbach, Alexander Storch
BACKGROUND: Since previous studies aimed to study nonmotor symptom (NMS) fluctuations in direct conjunction with motor oscillations, there are no data available on the temporal context of NMS fluctuations and motor oscillations in advanced Parkinson's disease (PD). OBJECTIVE: To evaluate circadian patterns and temporal connections of NMS and motor fluctuations in PD. METHODS: 15 controls, 17 non-fluctuating and 15 fluctuating PD patients completed two diaries by rating 4 key psychiatric (anxiety, depressive mood, inner restlessness, concentration/attention deficits), fatigue and 4 autonomic NMS (excessive sweating, sialorrhea, bladder urgency, dizziness) absent or present and motor function (Off, On with/without dyskinesia, and asleep) for every hour for 5 consecutive days...
May 31, 2016: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/27221328/-submandibular-gland-resection-for-the-management-of-sialorrhea-in-paediatric-patients-with-cerebral-palsy-and-unresponsive-to-type-a-botullinum-toxin-pilot-study
#18
Mario Sabas Hernández-Palestina, Juan Carlos Cisneros-Lesser, María Elena Arellano-Saldaña, Said Estibeyesbo Plascencia-Nieto
BACKGROUND: Sialorrhoea has a prevalence of between 10% and 58% in patients with cerebral palsy. Amongst the invasive treatments, botulinum toxin-A injections in submandibular and parotid glands and various surgical techniques are worth mentioning. There are no studies in Mexico on the usefulness of surgery to manage sialorrhoea. OBJECTIVE: To evaluate the usefulness of submandibular gland resection in improving sialorrhoea in patients with cerebral palsy and with a poor response to botulinum toxin...
May 21, 2016: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/27172341/effects-of-maropitant-in-cats-receiving-dexmedetomidine-and-morphine
#19
Manuel Martin-Flores, Daniel M Sakai, McKenzie M Learn, Alicia Mastrocco, Luis Campoy, Jordyn M Boesch, Robin D Gleed
OBJECTIVE To evaluate the effects of maropitant in cats receiving dexmedetomidine and morphine. DESIGN Randomized controlled trial. ANIMALS 66 healthy female domestic shorthair cats. PROCEDURES Cats were randomly assigned to receive maropitant (1 mg/kg [0.45 mg/lb], SC; maropitant group; n = 32) or saline (0.9% NaCl) solution (0.1 mL/kg [0.045 mL/lb], SC; control group; 34) 20 hours before IM administration of dexmedetomidine (20 μg/kg [9.1 μg/lb]) and morphine (0.1 mg/kg). Following administration of dexmedetomidine and morphine, the incidences of emesis, retching, and signs of nausea (sialorrhea and lip licking) were compared between the 2 groups...
June 1, 2016: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/27161101/clonidine-use-in-psychiatry-panacea-or-panache
#20
Ahmed Naguy
Clonidine, an alpha agonist, formally prescribed in clinical medicine as antihypertensive medication, is currently being used more frequently to address a multitude of psychiatric entities. The long-acting formulation is approved by the Food and Drug Administration for use in treating the attention-deficit/hyperactivity disorder. In addition to this only legitimate indication, it has long been used successfully for opiate detoxification, post-traumatic stress disorder and de la Tourette syndrome. Moreover, clonidine helps in the treatment of neuroleptic-induced akathisia, stimulant-induced insomnia and clozapine-induced sialorrhea...
2016: Pharmacology
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