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https://www.readbyqxmd.com/read/28264544/efficacy-of-bont-a-and-swallowing-treatment-for-oropharyngeal-dysphagia-recovery-in-a-patient-with-lateral-medullary-syndrome-a-case-study
#1
Irene Battel, Isabella Koch, Federica Biddau, Carla Carollo, Francesco Piccione, Francesca Meneghello, Merico Antonio, Katie Palmer, Rosario Marchese Ragona
BACKGROUND: Wallenberg's syndrome (WS) is known as posterior inferior cerebellar artery syndrome. Dysphagia has been reported from 51% to 94% of the patients, ranging from mild to severe. CASE PRESENTATION: We reported a case of a patient (Male; 52yrs) with WS. MRI showed an intense hypodense area in the dorsolateral part of the ponto-medullary junction. The clinical signs were severe dysphagia, fed by PEG (FOIS 1; PAS 7), sialorrhea, trismus and ataxia. CLINICAL REHABILITATION IMPACT: Dysphagia was treated by botulinum toxin tipe A (BoNT-A), which was injected into the parotid and submandibular salivary glands, temporalis and masseter muscles, cricopharyngeal muscle associated with specific swallowing exercise and food trails...
March 6, 2017: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28129312/the-effect-of-glycopyrrolate-on-nocturnal-sialorrhea-in-patients-using-clozapine-a-randomized-crossover-double-blind-placebo-controlled-trial
#2
Wai Hong Man, Jantine C A Colen-de Koning, Peter F J Schulte, Wiepke Cahn, Ingrid M M van Haelst, Hieronymus J Doodeman, Toine C G Egberts, Eibert R Heerdink, Ingeborg Wilting
BACKGROUND: Nocturnal sialorrhea is one of the most frequent adverse events in clozapine treatment. Symptomatic management of sialorrhea usually consists of off-label treatment with anticholinergic agents. The aim of the current study is to evaluate the efficacy and safety of glycopyrrolate in patients using clozapine that experience sialorrhea. METHODS: In a double-blind randomized crossover trial, patients with nocturnal sialorrhea (n = 32) were randomized to treatment with glycopyrrolate 1 mg or placebo...
January 26, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28109484/pediatric-trans-oral-submandibular-gland-excision-a-safe-and-effective-technique
#3
C A Hughes, J Brown
INTRODUCTION: In the pediatric population the submandibular gland requires removal in a number of conditions including, refractory recurrent sialoadenitis, sialolithiasis, salivary gland neoplasms and debilitating sialorrhea. In comparison to the traditional trans-cervical approach, the trans-oral route avoids a cervical scar, potential keloid formation and decreased risk of injury to the marginal mandibular branch of the facial nerve. This approach also eliminates the potentiality of remnant duct disease since the entire duct and papillae are removed...
February 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28081025/transdermal-scopolamine-withdrawal-syndrome-case-report-in-the-pediatric-cerebral-palsy-population
#4
Nasim A Chowdhury, Mary Laura Sewatsky, Heakyung Kim
Sialorrhea in children with cerebral palsy (CP) results in aspiration, decreased social integration, and poor quality of life. Management options include transdermal anticholinergics such as the scopolamine patch. A controlled clinical trial has proven botulinum toxin (BTX) injections into the salivary glands are an effective alternative to transdermal anticholinergics with a safer side effect profile. Multiple studies of the injections in diverse populations demonstrate reduction in saliva production with improvement in quality of life and decrease in hospitalization-associated costs...
January 9, 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/27929598/sclerotic-effect-of-oxytetracycline-on-the-submandibular-gland-an-experimental-model
#5
Oğuz Güçlü, Asli Muratli, Deniz Arik, Kazım Tekin, Halil Erdogan, Fevzi Sefa Dereköy
Oxytetracycline has been suggested as an alternate therapy for chronic recurrent sialadenitis and sialorrhea. We conducted an experimental study to investigate the sclerotic effect of this drug on the submandibular gland by histopathologic methods. Our subjects were 20 New Zealand white rabbits, which were divided into two groups of 10. The right submandibular gland of the rabbits in the active-treatment group was injected with 0.3 ml of oxytetracycline (100 mg/ml), and that of the controls was injected with saline...
December 2016: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/27911406/ultrasound-guided-botulinum-toxin-a-injections-a-method-of-treating-sialorrhea
#6
Pierangelo Barbero, Marco Busso, Carlo Alberto Artusi, Stefania De Mercanti, Marco Tinivella, Andrea Veltri, Luca Durelli, Marinella Clerico
Neurological diseases can be complicated by sialorrhea, an excessive flow of saliva. Patients suffering from moderate to severe sialorrhea have an impaired quality of life, often worsened by correlated complications such as aspiration pneumonia, oral infections, dental caries, and maceration of the skin. Diverse therapeutic approaches have been proposed for the treatment of sialorrhea, including surgery and the use of anticholinergic agents, with limited results and the possible occurrence of serious adverse events...
November 9, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27853957/a-guide-to-medications-inducing-salivary-gland-dysfunction-xerostomia-and-subjective-sialorrhea-a-systematic-review-sponsored-by-the-world-workshop-on-oral-medicine-vi
#7
REVIEW
Andy Wolff, Revan Kumar Joshi, Jörgen Ekström, Doron Aframian, Anne Marie Lynge Pedersen, Gordon Proctor, Nagamani Narayana, Alessandro Villa, Ying Wai Sia, Ardita Aliko, Richard McGowan, Alexander Ross Kerr, Siri Beier Jensen, Arjan Vissink, Colin Dawes
BACKGROUND: Medication-induced salivary gland dysfunction (MISGD), xerostomia (sensation of oral dryness), and subjective sialorrhea cause significant morbidity and impair quality of life. However, no evidence-based lists of the medications that cause these disorders exist. OBJECTIVE: Our objective was to compile a list of medications affecting salivary gland function and inducing xerostomia or subjective sialorrhea. DATA SOURCES: Electronic databases were searched for relevant articles published until June 2013...
March 2017: Drugs in R&D
https://www.readbyqxmd.com/read/27846048/scopolamine-ointment-for-clozapine-associated-sialorrhea-a-case-report
#8
Takashi Goto, Miyoko Kato, Yukiko Matsumura, Naoto Omata, Mari Yoshida, Kyohei Watanabe, Tetsuya Takahashi, Masato Higashima, Yuji Wada
No abstract text is available yet for this article.
February 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27816262/sublingual-atropine-in-the-treatment-of-clozapine-induced-sialorrhea
#9
Teofilo E Matos Santana, Noah A Capurso, Mohini Ranganathan, Gihyun Yoon
No abstract text is available yet for this article.
November 2, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27759834/application-of-botulinum-toxin-to-treat-sialorrhea-in-amyotrophic-lateral-sclerosis-patients-a-literature-review
#10
Ademar Francisco de Oliveira, Gêssyca Adryene de Menezes Silva, Débora Milenna Xavier Almeida
Amyotrophic lateral sclerosis is a progressive and fatal neurodegenerative disease characterized by the degeneration of motor neurons, which are the central nervous system cells that control voluntary muscle movements. The excessive salivation (sialorrhea) is present in approximately 50% of amyotrophic lateral sclerosis cases. Thus, some alternative therapeutic methods are sought, such as anticholinergic drugs and surgery. Recently the use of botulinum toxin applied at a midpoint of the salivary glands, often guided by ultrasound, have demonstrated positive results...
July 2016: Einstein
https://www.readbyqxmd.com/read/27759801/unusual-motor-and-non-motor-symptoms-and-signs-in-the-early-stage-of-parkinson-s-disease
#11
Hélio A G Teive, Délcio C Bertucci, Renato P Munhoz
Objective: Patients with Parkinson's disease (PD) may present with unusual motor and non-motor symptoms and signs in the early stage of the disease. Methods: Cases were collected over a five-year period at two tertiary movement disorders clinics. All had a diagnosis of PD with unusual presentations defined retrospectively as the presence of complaints not objectively related to any of the classic cardinal signs of parkinsonism or the typical early non-motor features of PD...
October 2016: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/27674872/unilateral-parotid-radiation-with-electron-beam-for-palliation-of-sialorrhea-in-als-patients-a-prospective-study
#12
B Dhanireddy, E J Kasarskis, M Bruno, C E Wooten, K E Vanderpool, W H St Clair
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27673032/poster-273-botulinum-toxin-injections-to-the-salivary-glands-for-treatment-of-sialorrhea-in-a-patient-with-duchenne-muscular-dystrophy-a-case-report
#13
Jonathan D Carrier, Kristin Caldera
No abstract text is available yet for this article.
September 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/27613712/pathophysiology-underlying-drooling-in-parkinson-s-disease-oropharyngeal-bradykinesia
#14
Mehmet Karakoc, Mehmet Ilker Yon, Gul Yalcin Cakmakli, Ersin Kasim Ulusoy, Aydin Gulunay, Nese Oztekin, Fikri Ak
We aimed to investigate the association between drooling and possible etiological factors in Parkinson's disease (PD) and to determine its effect on the quality of life. Demographic data of the 63 patients with idiopathic PD were recorded. Radboud Oral Motor Inventory for Parkinson's disease (ROMP) test was administered to all patients to evaluate speech, swallowing functions, and saliva control. The freezing of gait questionnaire (FOGQ) was used to evaluate gait and freezing of gait. Dynamic Parkinson gait scale (DYPAGS) was administered for the objective quantification of PD gait features...
December 2016: Neurological Sciences
https://www.readbyqxmd.com/read/27599097/histological-and-immunohistochemical-findings-of-the-action-of-botulinum-toxin-in-salivary-gland-systematic-review
#15
J B Oliveira, J Evêncio-Neto, L Baratella-Evêncio
The treatment of sialorrhea is necessary for the constant risks posed by hypersalivation. A new therapeutic option comes up with the application of botulinum toxin in salivary glands. However, little is known about its mechanism of action in glandular tissue. Based on the above, this work had the objective to systematically review the literature about the action of botulinum toxin on submandibular and parotid salivary glands tissues. Electronic search was performed in databases of great relevance for this study (PubMed, SciELO, HighWire, Crossref, Scopus, Science Direct, MEDLINE, OLDMEDLINE, Serials Database, NLM Catalog, LILACS and IBECS)...
September 5, 2016: Brazilian Journal of Biology, Revista Brasleira de Biologia
https://www.readbyqxmd.com/read/27586238/natural-outbreak-of-bvdv-1d-induced-mucosal-disease-lacking-intestinal-lesions
#16
M V Bianchi, G Konradt, S O de Souza, D M Bassuino, S Silveira, A C S Mósena, C W Canal, S P Pavarini, D Driemeier
Bovine viral diarrhea virus (BVDV) belongs to the Pestivirus genus, which is further divided into subgenotypes (1a-1u and 2a-c). When persistent infection occurs, the calf will be immunotolerant to BVDV and possibly develop mucosal disease. This study describes an outbreak of BVDV-1d-induced mucosal disease lacking intestinal lesions. Eleven calves presented with anorexia, sialorrhea, lameness, recumbency, and death. Three calves were necropsied, showing ulceration of the interdigital skin and the oral and nasal mucosa; linear ulcers in the tongue, esophagus, and rumen; and rounded ulcers in the abomasum...
March 2017: Veterinary Pathology
https://www.readbyqxmd.com/read/27538868/maropitant-administered-orally-2-2-5-h-prior-to-morphine-and-dexmedetomidine-reduces-the-incidence-of-emesis-in-cats
#17
Manuel Martin-Flores, Alicia Mastrocco, Augusto M Lorenzutti, Luis Campoy, Pati Kirch, Marisa Stone, McKenzie M Learn, Jordyn M Boesch
OBJECTIVES: The main goal of this study was to test the antiemetic effects of maropitant administered orally 2-2.5 h prior to morphine and dexmedetomidine in cats. METHODS: Eighty-three healthy female cats were randomized to receive maropitant (8 mg orally; n = 39) or no treatment (control; n = 44), 2-2.5 h prior to morphine 0.1 mg/kg and dexmedetomidine 20 µg/kg intramuscularly. The incidence of sialorrhea, lip licking, retching and vomiting were recorded after morphine/dexmedetomidine injection...
August 18, 2016: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/27526039/progressive-supranuclear-palsy-and-corticobasal-degeneration-pathophysiology-and-treatment-options
#18
REVIEW
Ruth Lamb, Jonathan D Rohrer, Andrew J Lees, Huw R Morris
There are currently no disease-modifying treatments for progressive supranuclear palsy (PSP) or corticobasal degeneration (CBD), and no approved pharmacological or therapeutic treatments that are effective in controlling their symptoms. The use of most pharmacological treatment options are based on experience in other disorders or from non-randomized historical controls, case series, or expert opinion. Levodopa may provide some improvement in symptoms of Parkinsonism (specifically bradykinesia and rigidity) in PSP and CBD; however, evidence is conflicting and where present, benefits are often negligible and short lived...
September 2016: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/27514242/botulinum-toxin-use-in-refractory-pain-and-other-symptoms-in-parkinsonism
#19
Veronica A Bruno, Susan H Fox, Deborah Mancini, Janis M Miyasaki
BACKGROUND: Parkinson's disease (PD) and other parkinsonian syndromes are chronic, progressive neurodegenerative diseases. With advancing disease, both motor and non-motor symptoms represent a considerable burden and symptom relief and quality of life improvement become the main goal of treatment. Botulinum toxins (BTX) are an effective treatment modality for many neurological conditions. METHODS: To understand the potential usefulness of BTX in this population, we performed a retrospective chart review of all patients with a clinical diagnosis of idiopathic PD and atypical parkinsonism who received treatment with BTX injections in our center from 1995 to 2014 for a variety of symptoms...
September 2016: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/27433087/gut-dysfunction-in-parkinson-s-disease
#20
REVIEW
Adreesh Mukherjee, Atanu Biswas, Shyamal Kumar Das
Early involvement of gut is observed in Parkinson's disease (PD) and symptoms such as constipation may precede motor symptoms. α-Synuclein pathology is extensively evident in the gut and appears to follow a rostrocaudal gradient. The gut may act as the starting point of PD pathology with spread toward the central nervous system. This spread of the synuclein pathology raises the possibility of prion-like propagation in PD pathogenesis. Recently, the role of gut microbiota in PD pathogenesis has received attention and some phenotypic correlation has also been shown...
July 7, 2016: World Journal of Gastroenterology: WJG
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