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https://www.readbyqxmd.com/read/29767912/gender-differences-in-the-perception-of-quality-of-life-of-patients-with-colorectal-cancer
#1
Isadora Trinquinato, Rodrigo Marques da Silva, Sonia Betzabeth Ticona Benavente, Camila Cristine Antonietti, Ana Lúcia Siqueira Costa Calache
OBJECTIVES: To identify the gender differences in assessing quality of life of patients undergoing chemotherapy treatment for colorectal cancer. METHODS: This is a cross-sectional investigation conducted with 144 patients (72 men and 72 women) undergoing chemotherapy treatment in a southeastern Brazilian hospital. Data were gathered trough a sociodemographic and clinical information form and the Health-related Quality of Life instrument from the European Organization for Research and Treatment of Cancer...
October 2017: Investigación y Educación en Enfermería
https://www.readbyqxmd.com/read/29764340/in-vitro-and-in-vivo-anti-cancer-activity-of-silymarin-on-oral-cancer
#2
Dong-Hoon Won, Lee-Han Kim, Boonsil Jang, In-Hyoung Yang, Hye-Jeong Kwon, Bohwan Jin, Seung Hyun Oh, Ju-Hee Kang, Seong-Doo Hong, Ji-Ae Shin, Sung-Dae Cho
Silymarin, a standardized extract from milk thistle fruits has been found to exhibit anti-cancer effects against various cancers. Here, we explored the anti-cancer activity of silymarin and its molecular target in human oral cancer in vitro and in vivo. Silymarin dose-dependently inhibited the proliferation of HSC-4 oral cancer cells and promoted caspase-dependent apoptosis. A human apoptosis protein array kit showed that death receptor 5 may be involved in silymarin-induced apoptosis, which was also shown through western blotting, immunocytochemistry, and reverse transcription-polymerase chain reaction...
May 2018: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/29756245/age-related-differences-in-health-related-quality-of-life-among-thyroid-cancer-survivors-compared-with-a-normative-sample-results-from-the-profiles-registry
#3
Floortje Mols, Dounya Schoormans, Jan W A Smit, Romana T Netea-Maier, Thera P Links, Winette T A van der Graaf, Olga Husson
BACKGROUND: The purpose of this study was to compare general health-related quality of life (HR-QOL) of thyroid cancer survivors with a normative sample stratified by age at diagnosis (adolescents and young adults 18-35 years; middle-aged adults 36-64 years; elderly 65-84 years), and to compare general HR-QOL and disease-specific symptoms among adolescents and young adults, middle-aged adults, and elderly thyroid cancer survivors in an exploratory population-based cross-sectional study...
May 13, 2018: Head & Neck
https://www.readbyqxmd.com/read/29753950/structure-of-the-lps-o-chain-from-fusobacterium-nucleatum-strain-mjr-7757-b
#4
Evgeny Vinogradov, Frank St Michael, Andrew D Cox
Fusobacterium nucleatum is an anaerobic bacterium found in the human mouth where it causes periodontitis. It was also found in colorectal cancer tissues and is linked with pregnancy complications, including pre-term and still births. Cell surface structures of the bacterium could be implicated in pathogenesis. Here we report the following structure of the lipopolysaccharide O-chain of F. nucleatum strain MJR 7757 B:where Lac is (R)-1-carboxyethyl (lactic acid residue); all monosaccharides are in the pyranose form...
April 25, 2018: Carbohydrate Research
https://www.readbyqxmd.com/read/29753688/citrus-fruits-intake-and-oral-cancer-risk-a-systematic-review-and-meta-analysis
#5
REVIEW
Santa Cirmi, Michele Navarra, Jayne V Woodside, Marie M Cantwell
OBJECTIVE: To quantify the relationship between Citrus intake and risk of cancer of the oral cavity and pharynx. DESIGN: Systematic review and meta-analysis. DATA SOURCES: Ovid MEDLINE, EMBASE, and Web of Science were searched until September 2017. Search terms included Citrus, Citrus aurantifolia, Citrus sinensis, Citrus paradisi, Citrus fruits, Citrus fruits extract, Citrus oil, fruits, oral cancer, mouth cancer, mouth neoplasm. STUDY SELECTION: The selection of studies and the systematic review were carried out in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement...
May 10, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29752180/-177-lu-psma-617-radionuclide-treatment-in-patients-with-metastatic-castration-resistant-prostate-cancer-lupsma-trial-a-single-centre-single-arm-phase-2-study
#6
Michael S Hofman, John Violet, Rodney J Hicks, Justin Ferdinandus, Sue Ping Thang, Tim Akhurst, Amir Iravani, Grace Kong, Aravind Ravi Kumar, Declan G Murphy, Peter Eu, Price Jackson, Mark Scalzo, Scott G Williams, Shahneen Sandhu
BACKGROUND: Progressive metastatic castration-resistant prostate cancer is a highly lethal disorder and new effective therapeutic agents that improve patient outcomes are urgently needed. Lutetium-177 [177 Lu]-PSMA-617, a radiolabelled small molecule, binds with high affinity to prostate-specific membrane antigen (PSMA) enabling beta particle therapy targeted to metastatic castration-resistant prostate cancer. We aimed to investigate the safety, efficacy, and effect on quality of life of [177 Lu]-PSMA-617 in men with metastatic castration-resistant prostate cancer who progressed after standard treatments...
May 7, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29748448/health-related-quality-of-life-in-oropharyngeal-cancer-survivors-a-population-based-study
#7
Thomas Guenzel, U Walliczek-Dworschak, A Teymoortash, S Singer, M Eichler, T Wilhelm, M Schimmer, A Franzen
OBJECTIVE: The aim of this study was to compare QoL of oropharyngeal cancer survivors who had received different treatments. SUBJECTS AND METHODS: We contacted 954 survivors. Each survivor received the QoL questionnaires EORTC QLQ-C30 and EORTC QLQ-H&N35. RESULTS: A total of 263 survivors completed the questionnaires (28% responses). Forty-five of them had undergone surgery, 20 had received definitive radiotherapy or chemo-radiotherapy, 85 surgery plus adjuvant radiotherapy, and 111 surgery plus adjuvant chemo-radiotherapy...
April 30, 2018: Otolaryngologia Polska
https://www.readbyqxmd.com/read/29747054/a-modification-of-the-bjork-flap-in-tracheostomies-for-head-and-neck-cancer-patients
#8
Panagiotis Stathopoulos, Leo Stassen
The etymology of the word tracheotomy derives from two Ancient Greek words: the word trachea (Greek τραχɛία tracheía) and the word stoma (Greek στóμα stóma) meaning "mouth," and refers to the making of an opening. It is believed that an early tracheostomy was performed by the Greek physician Asclepiades of Bithynia, in order to treat upper airway obstruction. A secure airway in the intraoperative and early postoperative period is of paramount importance for a number patients undergoing head and neck cancer surgery...
May 7, 2018: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29736758/socioeconomic-status-and-quality-of-life-in-patients-with-locally-advanced-head-and-neck-cancer
#9
S Tribius, M S Meyer, C Pflug, H Hanken, C-J Busch, A Krüll, C Petersen, C Bergelt
PURPOSE: Socioeconomic aspects play an important role in health care. Patients with locally advanced head and neck cancer (LAHNC) experience detrimental effects on their quality of life (QoL). This prospective study examines QoL differences between patients with different socioeconomic status (SES) after intensity-modulated radiation therapy (IMRT). PATIENTS AND METHODS: In all, 161 patients were questioned at the end of IMRT and at 12 and 24 months follow-up using the questionnaires of the European Organization for Research and Treatment of Cancer (EORTC) QLQ-30 and QLQ-HN35...
May 7, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29736489/promoting-oral-health-and-quality-of-life-of-older-people-the-need-for-public-health-action
#10
Poul Erik Petersen, Hiroshi Ogawa
PURPOSE: This report intends to review the global burden of oral disease among older people and to examine their oral health needs. The evidence on the inter-relationships between poor oral health conditions of older people, general health and quality of life is highlighted. Finally, WHO strategies to improve oral health of older people are reviewed. METHODS: The information relevant to this review was extracted from the WHO Global Oral Health Data Bank, the PubMed database, and the Cochrane Library...
2018: Oral Health & Preventive Dentistry
https://www.readbyqxmd.com/read/29731552/oral-cancer-statistics-in-india-on-the-basis-of-first-report-of-29-population-based-cancer-registries
#11
Swati Sharma, L Satyanarayana, Smitha Asthana, K K Shivalingesh, Bala Subramanya Goutham, Sujatha Ramachandra
Objectives: To summarize and provide an overview of age-specific oral cancer incidence reported in 29 population-based cancer registry in India. Materials and Methods: Secondary data on age-adjusted rates (AARs) of incidence of oral cancer and other associated sites for all ages (0-75 years) were collected from the report of the National Cancer Registry Programme 2012-2014 in 29 population-based control registries. Results: Among both males and females, mouth cancer had maximum Age adjusted incidence rates (64...
January 2018: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/29708355/-quality-of-life-after-high-dose-brachytherapy-in-patients-with-early-oral-carcinoma
#12
Helena Doležalová, Nicole Blechová, Jiří Petera
BACKGROUND: The prevalence of head and neck tumors has continually increased over the past decades, which is a serious medical and social problem. This study retrospectively assessed the quality of life of patients with early-stage oral cavity tumors after high-dose rate (HDR) brachytherapy. MATERIAL AND METHODS: Quality of life was evaluated in 14 patients with early-onset oral cavity tumors who underwent HDR brachytherapy at the Department of Oncology and Radiotherapy, University Hospital Hradec Kralove...
2018: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/29706184/definitive-chemoradiation-for-locally-advanced-oral-cavity-cancer-a-20-year-experience
#13
Corey C Foster, James M Melotek, Ryan J Brisson, Tanguy Y Seiwert, Ezra E W Cohen, Kerstin M Stenson, Elizabeth A Blair, Louis Portugal, Zhen Gooi, Nishant Agrawal, Everett E Vokes, Daniel J Haraf
OBJECTIVES: Definitive chemoradiation (CRT) for oral cavity squamous cell carcinoma (OC-SCC) is often criticized for poor efficacy or toxicity. We describe a favorable 20-year experience of primary CRT for locally-advanced OC-SCC. MATERIALS AND METHODS: Patients with locally-advanced, stage III/IV OC-SCC receiving primary concomitant CRT on protocols from 1994 to 2014 were analyzed. Chemotherapy included fluorouracil and hydroxyurea with other third agents. Radiotherapy (RT) was delivered once or twice daily to a maximum dose of 70-75 Gy...
May 2018: Oral Oncology
https://www.readbyqxmd.com/read/29696422/mouth-opening-device-as-a-treatment-modality-in-trismus-patients-with-head-and-neck-cancer-and-oral-submucous-fibrosis-a-prospective-study
#14
Yu-Hsuan Li, Wei-Chin Chang, Tien-En Chiang, Chiun-Shu Lin, Yuan-Wu Chen
OBJECTIVES: This study investigated the clinical effectiveness of intervention with an open-mouth exercise device designed to facilitate maximal interincisal opening (MIO) and improve quality of life in patients with head and neck (H&N) cancer and oral submucous fibrosis (OSF). MATERIALS AND METHODS: Sixty patients with H&N cancer, OSF, and trismus (MIO < 35 mm) participated in the functional rehabilitation program. An open-mouth exercise device intervention group and conventional group, each consisting of 20 patients, underwent a 12-week training and exercising program and follow-up...
April 26, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29694489/speech-language-therapy-program-for-mouth-opening-in-patients-with-oral-and-oropharyngeal-cancer-undergoing-adjuvant-radiotherapy-a-pilot-study
#15
Caroline Somera Marrafon, Leandro Luongo Matos, Marcia Simões-Zenari, Claudio Roberto Cernea, Katia Nemr
Purpose Assess the effectiveness of an orofacial myofunctional therapeutic program in patients with oral or oropharyngeal cancer submitted to adjuvant radiotherapy through pre- and post-program comparison of maximum mandibular opening. Methods Prospective study involving five adult patients and five elderly patients postoperatively to oral cavity/oropharynx surgery who were awaiting the beginning of radiotherapy or had undergone fewer than five treatment sessions. The study participants had their maximum jaw opening measured using a sliding caliper at the beginning and end of the program...
2018: CoDAS
https://www.readbyqxmd.com/read/29690934/multi-dimensional-analysis-of-oral-cavity-and-oropharyngeal-defects-following-cancer-extirpation-surgery-a-cadaveric-study
#16
Sherif Idris, Alex M Mlynarek, Khalid Ansari, Jeffrey R Harris, Nabil Rizk, David Cote, Daniel A O'Connell, Heather Allen, Peter Dziegielewski, Hadi Seikaly
BACKGROUND: Defects following resection of tumors in the head and neck region are complex; more detailed and defect-specific reconstruction would likely result in better functional and cosmetic outcomes. The objectives of our study were: 1) to improve the understanding of the two- and three-dimensional nature of oral cavity and oropharyngeal defects following oncological resection and 2) to assess the geometric dimensions and the shapes of fasciocutaneous free flaps and locoregional tissue flaps required for reconstruction of these defects...
April 24, 2018: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29690723/-effects-of-urethral-fibrosis-on-urinary-control-after-laparoscopic-radical-prostatectomy
#17
Y C Liang, Y P Wu, H Cai, S H Cheng, Y Wei, X Y Xue, Q S Zheng, J B Huang, Y Z Lin, N Xu
Objective: To determine the influence of urethral fibrosis on the recovery of urinary continence after laparoscopic radical prostatectomy. Method: A retrospective study of 203 patients from January 2010 to January 2014 who were underwent laparoscopic radical prostatectomy for prostate cancer in the First Affiliated Hospital of Fujian Medical University. The patients were divided into 2 groups according to preoperative T2-weighted magnetic resonance imaging of fibrosis status of the urethral wall and periurethral tissue...
April 10, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29681644/paraneoplastic-lambert-eaton-syndrome-in-a-patient-with-disseminated-metastatic-cancer
#18
Gregorio Arellano-Aguilar, Erik Santiago Núñez-Mojica, José Luis Gutiérrez-Velazco, Luis Gerardo Domínguez-Carrillo
Background: Neurological paraneoplastic syndromes are rare, occur in 0.01% of all cancer patients; like part of them, the Lambert-Eaton syndrome is an autoimmune presynaptic disorder of neuromuscular transmission characterized by muscle weakness and neurovegetative dysfunction, and often associated with small cell lung cancer. Case report: A 72 years old female with a family history of lung cancer and leukemia, with 7 months of dry cough and 3 months with waist and pelvic muscle weakness, oropharyngeal dysphagia, dry mouth, chronic constipation and weight loss of 10 kg...
2018: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/29674733/the-use-of-dental-implants-cast-bars-and-sleeve-overdentures-in-oral-cancer-patients
#19
R Ali, A Al-Khayatt, C Barclay
Surgical resection of an oral tumour (and the associated free flap reconstruction) can significantly alter the oral anatomy. The lack of sulcus depth, alveolar ridge, presence of a mobile flap and limited tongue movement can make it impossible for patients to control a removable prosthesis. To help this cohort of patients, dental implants can be invaluable. The Oral Rehabilitation Team at Central Manchester University Dental Hospital have used dental implants to rehabilitate oral cancer patients for over thirty years...
April 27, 2018: British Dental Journal
https://www.readbyqxmd.com/read/29665727/changes-in-central-line-associated-bloodstream-infection-rates-among-children-with-immune-compromised-conditions-an-11-year-review
#20
Lauri A Linder, Cheryl Gerdy, Yeonjung Jo, Andrew Wilson
This article describes changes in central line-associated bloodstream infection (CLABSI) rates among common causative organisms over an 11-year period on a pediatric inpatient unit prior to and following CLABSI reduction strategies. The setting for this descriptive cohort design study was a 32-bed inpatient unit in a tertiary pediatric hospital serving children with immune compromised conditions, including cancer and recipients of hematopoietic stem cell and solid organ transplants. Between January 2006 and December 2016, 265 CLABSIs involving 189 patients were reported...
April 1, 2018: Journal of Pediatric Oncology Nursing: Official Journal of the Association of Pediatric Oncology Nurses
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