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https://www.readbyqxmd.com/read/28095728/dental-prophylaxis-and-osteoradionecrosis
#1
C T Chang, S P Liu, C H Muo, C H Tsai, Y F Huang
The aim of this study was to investigate the association of different dental prophylactic modalities and osteoradionecrosis (ORN) and determine the risk of ORN under different timing periods of scaling, with the use chlorhexidine mouth rinse after surgery and with different strategies of fluoride gel application in head and neck cancer (HNC) participants. A cohort of 18,231 HNC participants, including 941 ORN patients and 17,290 matched control cases, were enrolled from a Longitudinal Health Insurance Database for Catastrophic Illness Patients (LHID-CIP) in Taiwan...
January 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28093356/laser-and-photochemotherapy-for-the-treatment-of-oral-mucositis-in-young-patients-randomized-clinical-trial
#2
João Batista Medeiros Filho, Etevaldo Matos Maia Filho, Meire Coelho Ferreira
BACKGROUND: The aim of the present study was to evaluate the effect of low-level laser therapy (LLLT) combined with photochemotherapy (PCT) for the treatment of chemotherapy-induced oral mucositis in young patients. METHODS: A randomized, blind, clinical trial with a split-mouth design was conducted involving a sample of 15 cancer patients aged three to 16 years at the Aldenora Bello Hospital in the city of São Luís, Brazil. The treatments (PCT+LLLT and LLLT alone) were randomly determined for each side of the oral cavity...
January 13, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28078129/osteonecrosis-of-the-jaw-associated-with-ziv-aflibercept
#3
Hani Mawardi, Peter Enzinger, Nadine McCleary, Reshma Manon, Alessandro Villa, Nathaniel Treister, Sook-Bin Woo
Medication-related osteonecrosis of the jaw (MRONJ) has been associated with medications that include bisphosphonates (BPs), denosumab, bevacizumab and sunitinib. Ziv-aflibercept is a recombinant human vascular endothelial growth factor (VEGF) receptor which has been used to treat patients with various advanced solid tumors. We report three patients without a history of the use of medications known to cause MRONJ presenting with jaw osteonecrosis typical for MRONJ following therapy with ziv-aflibercept. All patients had metastatic gastrointestinal cancer treated with ziv-aflibercept and were evaluated for MRONJ because of exposed bone in the oral cavity...
December 2016: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28075428/balanced-secretion-of-anti-cea-x-anti-cd3-diabody-chains-using-the-2a-self-cleaving-peptide-maximizes-diabody-assembly-and-tumor-specific-cytotoxicity
#4
K Mølgaard, M Compte, N Nuñez-Prado, S L Harwood, L Sanz, L Alvarez-Vallina
Adoptive transfer of genetically engineered human cells secreting bispecific T cell engagers has shown encouraging therapeutic effects in preclinical models of cancer. However, reducing the toxicity and improving the effectiveness of this emerging immunotherapeutic strategy will be critical to its successful application. We have demonstrated that for gene-based bispecific antibody strategies, two-chain diabodies have a better safety profile than single-chain tandem scFvs, because their reduced tendency to form aggregates reduces the risk of inducing antigen-independent T cell activation...
January 11, 2017: Gene Therapy
https://www.readbyqxmd.com/read/28062340/differences-in-symptom-burden-among-cancer-patients-with-different-stages-of-cachexia
#5
Ting Zhou, Kaixiang Yang, Sudip Thapa, Huiquan Liu, Bangyan Wang, Shiying Yu
CONTEXT: Cancer patients with cachexia may suffer from significant burden of symptoms and it can severely impair patients' quality of life. However, only few studies have targeted the symptom burden in cancer cachexia patients, and whether the symptom burden differed in different cachexia stages is still unclear. OBJECTIVES: The aims of this study were to evaluate the symptom burden in cancer cachexia patients, and to compare the severity and occurrence rates of symptoms among cancer patients with non-cachexia, pre-cachexia, cachexia and refractory cachexia...
January 3, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28053964/the-evaluation-of-p53-polymorphism-at-codon-72-and-association-with-breast-cancer-in-iran-a-systematic-review-and-meta-analysis
#6
Abozar Soleimani, Yousef Rahmani, Negin Farshchian, Ali Delpisheh, Kivan Khassi, Afshar Shahmohammadi, Nasrin Amirifard
BACKGROUND: Breast cancer is the most common cancer among women in Iran and the world. Multiple environmental factors and genetic variations such as genetic polymorphisms are of its main causes. p53 gene plays an important role in conserving and sustaining the genome as a tumor suppressing gene. Change and polymorphism at codon 72 of p53 gene are correlated with increased risk of lung, mouth, endometrial, prostate, and colorectal cancers, and could be considered an indicator of susceptibility to breast cancer...
December 2016: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28048503/su-d-204-04-correlations-between-dosimetric-indices-and-follow-up-data-for-salivary-glands-six-months-after-radiation-therapy-for-head-and-neck-cancer
#7
B Chera, A Price, M Kostich, R Amdur, W Mendenhall, N Sheets, R Green, L Marks, S Das, P Mavroidis
PURPOSE: To investigate the correlation between different dosimetric indices of salivary glands (as separate or combined structures) to patient-reported dry mouth 6 months post radiotherapy using the novel patient reported outcome version of the CTCAE (PRO-CTCAE). METHODS: Forty-three patients with oropharyngeal squamous cell carcinoma were treated on a prospective multi-institutional study. All patients received de-intensified 60 Gy intensity modulated radiotherapy...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048452/we-fg-202-07-an-mri-based-approach-to-quantify-radiation-induced-normal-tissue-injury-applied-to-trismus-after-head-and-neck-cancer-radiotherapy
#8
M Thor, N Tyagi, V Hazoglou, Z Saleh, N Riaz, N Lee, J Deasy
PURPOSE: The aim of this study was to investigate if quantitative MRI-derived metrics from four masticatory muscles could explain mouth-opening limitation/trismus following intensity-modulated radiotherapy (IMRT) for head and neck cancer (HNC). METHODS: Fifteen intensity-based MRI metrics were derived from the masseter, lateral and medial pterygoid, and temporalis in T1-weighted scans acquired pre- and post gadolinium injection (T1Pre, T1Post) of 16, of in total 20, patients (8 symptomatic; 8 asymptomatic age/sex/tumor location-matched) treated with IMRT to 70 Gy (median) for HNC in 2005-2009...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046569/we-ab-207b-08-exploring-and-refining-the-quantec-guideline-to-reduce-severe-hyposalivation-following-imrt-for-head-and-neck-cancer
#9
M Thor, A Owosho, H Rosenburg, S Yom, J Oh, N Riaz, J Tsai, N Lee, J Huryn, C Estilo, J Deasy
PURPOSE: The aim of this study was to investigate the usefulness of the QUANTEC guideline to prevent xerostomia after intensity-modulated radiotherapy (IMRT) for head and neck cancer (HNC) with respect to follow-up time. In addition, we explored alternative guidelines to further reduce xerostomia. METHODS: The QUANTEC guideline suggests a mean dose to the contralateral (Dmeancontra) parotid<20 Gy, or Dmeancontra and Dmean to the ipsilateral parotid (Dmeanipsi)<25 Gy...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28043745/the-efficacy-of-hyperbaric-oxygen-therapy-related-to-the-clinical-stage-of-osteoradionecrosis-of-the-mandible
#10
F J Dieleman, T T T Phan, F J A van den Hoogen, J H A M Kaanders, M A W Merkx
This study aimed to evaluate the success of hyperbaric oxygen therapy (HBOT) and surgery in the treatment of mandibular osteoradionecrosis (ORN) in relation to the extent of the ORN. Twenty-seven patients with ORN were identified from a total of 509 patients with a history of primary oral or base of the tongue cancer; these patients had been treated with radiation therapy with curative intent between 1992 and 2006, with a radiation dose to the mandible of ≥50Gy. The ORN was staged according to the classification of Notani et al...
December 30, 2016: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28034402/transoral-robotic-surgery
#11
Shokjean Yee
Transoral robotic surgery (TORS) is a technique used to treat oral, throat, and skull base cancers using a minimally invasive robotic approach through the mouth and throat. The TORS procedure allows deeper access and dissection of suspicious lesions and neoplastic growths in the oral cavity and those that extend from the throat to the base of the skull. Robotic surgery allows the surgeon to operate in tight spaces without a large open incision. This article discusses symptoms and risk factors of oral, throat, and skull base cancers; types of procedures that can be performed using the TORS approach; specialized instrumentation; patient selection; surgical advantages and disadvantages; patient benefits; and the role of the surgical team in preparing to intraoperatively care for the TORS patient...
January 2017: AORN Journal
https://www.readbyqxmd.com/read/28017447/association-between-cachexia-chemotherapy-and-outcomes-in-older-cancer-patients-a-systematic-review
#12
REVIEW
Philippe Caillet, Evelyne Liuu, Agathe Raynaud Simon, Marc Bonnefoy, Olivier Guerin, Gilles Berrut, Bruno Lesourd, Claude Jeandel, Monique Ferry, Yves Rolland, Elena Paillaud
BACKGROUND & AIMS: The aims of this systematic review were (i) to determine the prevalence of malnutrition and cachexia in older cancer patients in a chemotherapy setting, and (ii) to report the chemotherapy-related causes of malnutrition and (iii) the consequences of malnutrition on the outcomes of these patients. METHODS: We searched MEDLINE for articles published in English or French between 2005 and 2016 and which reported retrospective or prospective, observational or interventional studies of the prevalence of malnutrition and its consequences in patients 65 years or older with solid tumors and chemotherapy-related causes of malnutrition...
December 18, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28011180/influence-of-bone-invasion-on-outcomes-after-marginal-mandibulectomy-in-squamous-cell-carcinoma-of-the-oral-cavity
#13
Ivana Petrovic, Pablo H Montero, Jocelyn C Migliacci, Frank L Palmer, Ian Ganly, Snehal G Patel, Jatin P Shah
INTRODUCTION: Marginal mandibulectomy (MM) is indicated for oral cavity squamous cell carcinomas (OCSCC) that abut or minimally erode the mandible without gross invasion. Successful implementation of MM is predicated on accurate patient selection and appropriate adjuvant treatment based on well-known host and tumor characteristics. The incidence of microscopically diagnosed bone involvement in MM specimens and its implications on outcomes have however not been reported in large contemporary series...
November 30, 2016: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/27997560/activation-of-human-salivary-aldehyde-dehydrogenase-by-sulforaphane-mechanism-and-significance
#14
Md Fazle Alam, Amaj Ahmed Laskar, Lubna Maryam, Hina Younus
Cruciferous vegetables contain the bio-active compound sulforaphane (SF) which has been reported to protect individuals against various diseases by a number of mechanisms, including activation of the phase II detoxification enzymes. In this study, we show that the extracts of five cruciferous vegetables that we commonly consume and SF activate human salivary aldehyde dehydrogenase (hsALDH), which is a very important detoxifying enzyme in the mouth. Maximum activation was observed at 1 μg/ml of cabbage extract with 2...
2016: PloS One
https://www.readbyqxmd.com/read/27993721/foot-and-mouth-disease-virus-like-particles-as-integrin-based-drug-delivery-system-achieve-targeting-anti-tumor-efficacy
#15
Dan Yan, Zhidong Teng, Shiqi Sun, Shan Jiang, Hu Dong, Yuan Gao, Yanquan Wei, Wenwu Qin, Xiangtao Liu, Hong Yin, Huichen Guo
The surface of foot-and-mouth disease virus (FMDV)-like particles (VLPs) contains a conserved arginine-glycine-aspartic acid (RGD) motif. Natural FMDV specifically attaches to overexpressed integrin receptors in several cancer cells. The FMDV VLPs produced in Escherichia coli were used for the first time as a delivery system of anti-tumor drug doxorubicin (DOX). The DOX-loaded VLPs exhibited a distinct release profile in different physiological conditions. The effects of FMDV-VLPs-DOX on cellular internalization and viability were evaluated in vitro by cell imaging, MTT assay and apoptosis, respectively...
December 18, 2016: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/27990487/tuning-hydrogel-properties-to-promote-the-assembly-of-salivary-gland-spheroids-in-3d
#16
Tugba Ozdemir, Eric W Fowler, Shuang Liu, Daniel A Harrington, Robert L Witt, Mary C Farach-Carson, Swati Pradhan-Bhatt, Xinqiao Jia
Current treatments for chronic xerostomia, or "dry mouth", do not offer long-term therapeutic benefits for head and neck cancer survivors previously treated with curative radiation. Towards the goal of creating tissue-engineered constructs for the restoration of salivary gland functions, we developed new hyaluronic acid (HA)-based hydrogels using thiolated HA (HA-SH) and acrylated HA (HA-AES) with a significant molecular weight mismatch. Four hydrogel formulations with varying HA concentration, (1-2.4 wt%) and thiol/acrylate ratios (2/1 to 36/1) and elastic moduli (G': 35 to 1897 Pa, 2 h post-mixing) were investigated...
December 12, 2016: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/27987094/role-of-benzydamine-hydrochloride-in-the-prevention-of-oral-mucositis-in-head-and-neck-cancer-patients-treated-with-radiotherapy-50%C3%A2-gy-with-or-without-chemotherapy
#17
Madhup Rastogi, Rohini Khurana, Swaroop Revannasiddaiah, Isha Jaiswal, Sambit S Nanda, Pooja Gupta, Kundan S Chufal, M L Bhatt
PURPOSE: Benzydamine is recommended for prophylaxis of oral mucositis (OM) in head and neck cancer (HNC) patients for radiation doses (<50 Gy). This study evaluates role of benzydamine for higher radiation doses (>50 Gy) with or without chemotherapy. METHODS: One hundred twenty patients of HNC with planned radiation doses of ≥60 Gy were randomized to group A (control radiotherapy alone), group B (study radiotherapy alone), group C (control chemoradiotherapy), or to group D (study chemoradiotherapy)...
December 16, 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/27966024/comparing-the-symptom-experience-of-cancer-patients-and-non-cancer-patients
#18
Teresa L Deshields, Valentina Penalba, Jingxa Liu, James Avery
PURPOSE: Symptom burden is an established concept in oncology encompassing the presence and severity of symptoms experienced by cancer patients. Few studies have examined differences in symptom burden between cancer patients and non-cancer patients. This study seeks to examine the differences in symptom burden between cancer patients (CP) and non-cancer patients (NCP) in order to better understand symptom burden in both populations. METHODS: Two groups of patients completed the Memorial Symptom Assessment Scale: 301 patients from a general medical clinic and 558 cancer patients from a cancer tumor registry...
December 13, 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/27965479/role-of-dental-profession-in-oral-cancer-prevention-and-diagnosis
#19
Q A Hussain, K H Awan
The incidence of oral cancer is increasing worldwide. Malignant neoplasms of the mouth and pharynx have been rated as the 10th most common cancer in men and 7th in women, though geographical variations exist.(1)Generally, in a society, oral cancer is not properly understood. The sign and symptoms are frequently overlooked in the initial stages when it is responsive to treat.
December 1, 2016: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/27965023/believability-of-cigar-warning-labels-among-adolescents
#20
Sarah D Kowitt, Kristen Jarman, Leah M Ranney, Adam O Goldstein
PURPOSE: Despite high rates of cigar use among youth, little information exists about how cigar warnings are received by youth. We examined believability of different cigar warning messages with different sources among adolescents in a national phone survey. METHODS: Adolescents (aged 13-17 years) in the US (N = 1,125; total response rate, 66%) were randomized to receive one of three health messages ("cigar smoking can cause cancers of the mouth and throat, even if you do not inhale," "cigar smoking can cause lung cancer and heart disease," and "cigars are not a safe alternative to cigarettes") and one of four warning sources (Food and Drug Administration, Surgeon General, Centers for Disease Control and Prevention, and no source)...
December 10, 2016: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
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