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https://www.readbyqxmd.com/read/29343167/a-cluster-randomised-feasibility-trial-of-clinically-assisted-hydration-in-cancer-patients-in-the-last-days-of-life
#1
Andrew N Davies, Melanie Waghorn, Katherine Webber, Sigurd Johnsen, Jeewaka Mendis, Julia Boyle
BACKGROUND: The provision of clinically assisted hydration at the end-of-life is one of the most contentious issues in medicine. AIM: The aim of this feasibility study was to answer the question 'can a definitive (adequately powered) study be done?' DESIGN: The study was a cluster randomised trial, with sites randomised on a one-to-one basis to intervention 'A' (regular mouth care and usual other care) or intervention 'B' (clinically assisted hydration, mouth care and usual other care)...
January 1, 2018: Palliative Medicine
https://www.readbyqxmd.com/read/29338080/phase-1-trial-evaluating-cisplatin-gemcitabine-and-veliparib-in-2-patient-cohorts-germline-brca-mutation-carriers-and-wild-type-brca-pancreatic-ductal-adenocarcinoma
#2
Eileen M O'Reilly, Jonathan W Lee, Maeve A Lowery, Marinela Capanu, Zsofia K Stadler, Malcolm J Moore, Neesha Dhani, Hedy L Kindler, Hayley Estrella, Hannah Maynard, Talia Golan, Amiel Segal, Erin E Salo-Mullen, Kenneth H Yu, Andrew S Epstein, Michal Segal, Robin Brenner, Richard K Do, Alice P Chen, Laura H Tang, David P Kelsen
BACKGROUND: A phase 1 trial was used to evaluate a combination of cisplatin, gemcitabine, and escalating doses of veliparib in patients with untreated advanced pancreatic ductal adenocarcinoma (PDAC) in 2 cohorts: a germline BRCA1/2-mutated (BRCA+) cohort and a wild-type BRCA (BRCA-) cohort. The aims were to determine the safety, dose-limiting toxicities (DLTs), maximum tolerated dose, and recommended phase 2 dose (RP2D) of veliparib combined with cisplatin and gemcitabine and to assess the antitumor efficacy (Response Evaluation Criteria in Solid Tumors, version 1...
January 16, 2018: Cancer
https://www.readbyqxmd.com/read/29337392/oral-health-related-concerns-behavior-and-communication-with-health-care-providers-of-patients-with-breast-cancer-impact-of-different-treatments
#3
L Susan Taichman, Catherine H Van Poznak, Marita R Inglehart
AIM: The objectives are to compare responses of breast cancer (BCa) treatment groups (chemotherapy, tamoxifen, and aromatase inhibitors (AIs) to each other and a control regarding (a) subjective oral health, (b) oral health-related behaviors, (c) oral health-related concerns, and (d) communication with health care providers. METHODS: Survey data were collected from 140 postmenopausal BCa patients and 41 healthy postmenopausal control respondents. RESULTS: BCa patients reported on average more frequent mouth sores/mucositis (5-point scale with 1 = never: 1...
January 16, 2018: Special Care in Dentistry
https://www.readbyqxmd.com/read/29328529/hinokitiol-ablates-myofibroblast-activation-in-precancerous-oral-submucous-fibrosis-by-targeting-snail
#4
Hui-Wen Yang, Ming-Yi Lu, Yu-Wei Chiu, Yi-Wen Liao, Yu-Feng Huang, Pin Ju Chueh, Pei-Ling Hsieh, Cheng-Chia Yu
Oral submucous fibrosis (OSF) is a precancerous condition with symptoms of limited mouth opening and areca nut chewing habit has been implicated in its pathogenesis. Hinokitiol, a natural tropolone derived from Chamacyparis taiwanensis, has been reported to improve oral lichen planus and inhibit various cancer cells. Here, we showed that hinokitiol reduced the myofibroblast activities in fBMFs and prevented the arecoline-induced transdifferentiation. Treatment of hinokitiol dose-dependently downregulated the myofibroblast markers as well as various EMT transcriptional factors...
January 12, 2018: Environmental Toxicology
https://www.readbyqxmd.com/read/29327682/analysis-of-implementiation-of-4th-head-and-neck-cancer-awareness-week-in-department-of-otolaryngology-in-mi%C3%A4-dzyleski-hospital-in-warsaw
#5
Karolina Dżaman, Karolina Piskadło-Zborowska, Mirosława Pietniczka-Załęska
INTRODUCTION: The aim of the study was to analyze the profile of patients applying for free preventive examinations within The Forth European Head an Neck Cancer (HNC) Awareness Week in the Department of Otorhynolaryngology in Międzyleski Hospital in Warsaw (ORL MSS). MATERIAL AND METHODS: A media campaign was designed to inform HNC risk patients about the opportunity to receive free preventive examinations in ORL MSS. 225 patients were enrolled to the study. Patient age ranged from 26 to 92 (average 63 years)...
August 31, 2017: Otolaryngologia Polska
https://www.readbyqxmd.com/read/29324904/prohibitin-plays-a-critical-role-in-enterovirus-71-neuropathogenesis
#6
Issac Horng Khit Too, Isabelle Bonne, Eng Lee Tan, Justin Jang Hann Chu, Sylvie Alonso
A close relative of poliovirus, enterovirus 71 (EV71) is regarded as an important neurotropic virus of serious public health concern. EV71 causes Hand, Foot and Mouth Disease and has been associated with neurological complications in young children. Our limited understanding of the mechanisms involved in its neuropathogenesis has hampered the development of effective therapeutic options. Here, using a two-dimensional proteomics approach combined with mass spectrometry, we have identified a unique panel of host proteins that were differentially and dynamically modulated during EV71 infection of motor-neuron NSC-34 cells, which are found at the neuromuscular junctions where EV71 is believed to enter the central nervous system...
January 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29315944/the-effectiveness-of-a-saline-mouth-rinse-regimen-and-education-programme-on-radiation-induced-oral-mucositis-and-quality-of-life-in-oral-cavity-cancer-patients-a-randomised-controlled-trial
#7
B-S Huang, S-C Wu, C-Y Lin, K-H Fan, J T-C Chang, S-C Chen
Radiation therapy (RT) and concurrent chemotherapy RT (CCRT) generate radiation-induced oral mucositis (OM) and lower quality of life (QOL). This study assessed the impact of a saline mouth rinse regimen and education programme on radiation-induced OM symptoms, and QOL in oral cavity cancer (OCC) patients receiving RT or CCRT. Ninety-one OCC patients were randomly divided into a group that received saline mouth rinses and an education programme and a control group that received standard care. OM symptoms and QOL were assessed with the WHO Oral Toxicity Scale, MSS-moo and UW-QOL...
January 9, 2018: European Journal of Cancer Care
https://www.readbyqxmd.com/read/29313973/mouse-model-of-post-surgical-primary-tumor-recurrence-and-regional-lymph-node-metastasis-progression-in-hpv-related-head-and-neck-cancer
#8
Maxime Mermod, Agnès Hiou-Feige, Esther Bovay, Vincent Roh, Jana Sponarova, Massimo Bongiovanni, Daniel W Vermeer, John H Lee, Tatiana V Petrova, Jean-Paul Rivals, Yan Monnier, Genrich V Tolstonog, Christian Simon
HPV-positive head and neck squamous cell carcinoma (HNSCC) is increasingly frequent. Management is particularly debated in the case of post-surgical high-risk features, i.e., positive surgical margins and extracapsular spread (ECS). In this increasingly complex emerging framework of HNSCC treatment, representative pre-clinical models are needed to support future clinical trials and advances in personalized medicine. Here, we present an immunocompetent mouse model based on the implantation of mouse tonsil epithelial HPV16-E6/E7-expressing cancer cells into the submental region of the floor-of-the-mouth...
January 4, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29313134/the-effectiveness-of-zataria-extract-mouthwash-for-the-management-of-radiation-induced-oral-mucositis-in-patients-a-randomized-placebo-controlled-double-blind-study
#9
Azar Aghamohammadi, Daryush Moslemi, Jafar Akbari, Arash Ghasemi, Mohammad Azadbakht, Askari Asgharpour, Seyed Jalal Hosseinimehr
OBJECTIVES: Oral mucositis (OM) is a common debilitating complication of chemoradiotherapy treatment of head and neck cancers. This randomized placebo-controlled double-blind clinical trial study was performed to evaluate the effectiveness of Zataria multiflora (ZM) extract mouthwash in the prevention and reduction of OM related to local radiotherapy in the treatment of head and neck cancer patients. METHODS: Sixty-three patients with head and neck cancers, who underwent a conventional fractionated radiotherapy regimen, were entered into the study...
January 8, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29302374/using-quality-of-life-scales-with-nutritional-relevance-after-gastrectomy-a-challenge-for-providing-personalized-treatment
#10
Seung Soo Lee, Wansik Yu, Ho Young Chung, Oh Kyoung Kwon, Won Kee Lee
Purpose: This study evaluated the changes in nutritional status based on quality of life (QoL) item-level analysis to determine whether individual QoL responses might facilitate personal clinical impact. Materials and Methods: This study retrospectively evaluated QoL data obtained by the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire-Core 30 (QLQ-C30) and Quality of Life Questionnaire-Stomach (QLQ-STO22) as well as metabolic-nutritional data obtained by bioelectrical impedance analysis and blood tests...
December 2017: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/29300352/risk-assessment-for-children-exposed-to-arsenic-on-baseball-fields-with-contaminated-fill-material
#11
Alesia C Ferguson, Jennifer C Black, Isaac B Sims, Jennifer N Welday, Samir M Elmir, Kendra F Goff, J Mark Higginbotham, Helena M Solo-Gabriele
Children can be exposed to arsenic through play areas which may have contaminated fill material from historic land use. The objective of the current study was to evaluate the risk to children who play and/or spend time at baseball fields with soils shown to have arsenic above background levels. Arsenic in soils at the study sites located in Miami, FL, USA showed distinct distributions between infield, outfield, and areas adjacent to the fields. Using best estimates of exposure factors for children baseball scenarios, results show that non-cancer risks depend most heavily upon the age of the person and the arsenic exposure level...
January 4, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29286228/effects-of-damnacanthal-and-nordamnacanthal-on-proliferation-apoptosis-and-migration-of-oral-squamous-cell-carcinoma-cells
#12
Gohar Shaghayegh, Aied M Alabsi, Rola Ali-Saeed, Abdul Manaf Ali, Vui King Vincent-Chong, Nor Hadiani Ismail, Y F Choon, Rosnah Binti Zain
Cancer is one of the most common causes of death in the developed world, with one-third of people diagnosed with cancer during their lifetime. Oral cancer commonly occurs involving the buccal mucosa (cheeks), tongue, floor of the mouth and lip. It is one of the most devastating and disfiguring of malignancies. Morinda citrifolia L., commonly known as ‘noni’, belongs to the Rubiaceae family. It is native to the Pacific islands, Hawaii, Caribbean, Asia and Australia. The plant displays broad curative effects in pharmacological studies...
December 29, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29274153/oral-cancer-a-multicenter-study
#13
K Dhanuthai, S Rojanawatsirivej, W Thosaporn, S Kintarak, A Subarnbhesaj, M Darling, E Kryshtalskyj, C-P Chiang, H-I Shin, S-Y Choi, S-S Lee, P-A Shakib
BACKGROUND: To determine the prevalence and clinicopathologic features of the oral cancer patients. MATERIAL AND METHODS: Biopsy records of the participating institutions were reviewed for oral cancer cases diagnosed from 2005 to 2014. Demographic data and site of the lesions were collected. Sites of the lesion were subdivided into lip, tongue, floor of the mouth, gingiva, alveolar mucosa, palate, buccal/labial mucosa, maxilla and mandible. Oral cancer was subdivided into 7 categories: epithelial tumors, salivary gland tumors, hematologic tumors, bone tumors, mesenchymal tumors, odontogenic tumors, and others...
December 23, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/29274149/evolution-of-oral-neoplasm-in-an-andalusian-population-spain
#14
R Flores-Ruiz, L Castellanos-Cosano, M-A Serrera-Figallo, A Gutierrez-Corrales, R Castillo-Oyague, J-L Gutierrez-Pere, D Torres-Lagares
BACKGROUND: Head and neck cancer are one of the most common neoplasm pathologies in humans. The aim of this study was to analyze the type, characteristics, treatment and evolution of oral neoplasm or precancerous lesion in a sample of Andalusian population (Spain) derived from the Oncology Rehabilitation Hospital Unit during a period of 20 years. MATERIAL AND METHODS: A retrospective descriptive study was carried out during the years 1991 and 2011 analyzing the type, characteristics, treatment and follow-up of oral neoplasm in the Oral and Maxillofacial Surgery Unit of the Universitary Hospital Virgen del Rocio...
December 23, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/29248948/secondary-metabolites-and-their-biological-activity-from-aspergillus-aculeatus-kku-ct2
#15
Natanong Yodsing, Ratsami Lekphrom, Watchara Sangsopha, Tadanori Aimi, Sophon Boonlue
The bioactive compounds of the fungus Aspergillus aculeatus strain KKU-CT2, have been studied. The crude extracts from this fungus showed good antimicrobial activity against human pathogens, including Gram-positive and Gram-negative bacteria and yeast-like fungi. Its chemical components were isolated and purified by chromatographic methods. The structures of the secondary metabolites were elucidated by spectroscopic methods (IR, 1H, and 13C NMR). They were identified as ergosterol peroxide (1), secalonic acid D (2), secalonic acid F (3), variecolin (4), variecolactone (5), and ergosterol (6)...
December 16, 2017: Current Microbiology
https://www.readbyqxmd.com/read/29242026/the-localization-and-risk-factors-of-squamous-cell-carcinoma-in-the-oral-cavity-a-retrospective-study-of-1501-cases
#16
Britta V Sundermann, Lorenz Uhlmann, Jürgen Hoffmann, Kolja Freier, Oliver C Thiele
Head and neck cancer is the tenth leading cause of cancer mortality. Ninety percent of tumours in the oral cavity are squamous cell carcinomas. Information about the exact localisation of OSCC is missing in the literature. In the present study, we retrospectively analysed a total of 1501 OSCC patients, who were treated between 1975 and 2009. The purpose of this study was to examine the localisation of OSCC tumours and to analyse the influence of various parameters on tumour localisation. 71.5% of these patients were male and 28...
October 31, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29233698/ex-corpore-linguae-a-cohort-analysis-after-a-unique-surgical-technique-in-oral-cancer-resection
#17
Jan-Falco Wilbrand, Daniel Schmermund, Michael Knitschke, Philipp Streckbein, Christopher Kähling, Heiko Kerkmann, Heidrun Schaaf, Hans-Peter Howaldt, Sebastian Böttger
OBJECTIVE: Resection of posteriorly located oral squamous cell carcinomas (OSCCs) remains challenging for head and neck surgeons. However, several surgical techniques, such as lip and mandibular splitting, as well as submental "visor drop-down" of intraoral soft tissues, have been proposed for this purpose. Merrick et al. suggested that a pedicled genial drop-down surgical approach should be used to resect dorsally located OSCCs. Our study investigated patient outcomes following this surgical procedure, as no previous study has analyzed long-term follow-up data...
November 21, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29229507/patient-reported-dry-mouth-instrument-comparison-and-model-performance-for-correlation-with-quality-of-life-in-head-and-neck-cancer-survivors
#18
Mona Kamal, David I Rosenthal, Stefania Volpe, Ryan P Goepfert, Adam S Garden, Katherine A Hutcheson, Karine A Al Feghali, Mohamed Ahmed Mohamed Meheissen, Salman A Eraj, Amy E Dursteler, Bowman Williams, Joshua B Smith, Jeremy M Aymard, Joel Berends, Aubrey L White, Steven J Frank, William H Morrison, Richard Cardoso, Mark S Chambers, Erich M Sturgis, Tito R Mendoza, Charles Lu, Abdallah S R Mohamed, Clifton D Fuller, G Brandon Gunn
PURPOSE: To identify a clinically meaningful cut-point for the single item dry mouth question of the MD Anderson Symptom Inventory-Head and Neck module (MDASI-HN). METHODS: Head and neck cancer survivors who had received radiation therapy (RT) completed the MDASI-HN, the University of Michigan Hospital Xerostomia Questionnaire (XQ), and the health visual analog scale (VAS) of the EuroQol Five Dimension Questionnaire (EQ-5D). The Bayesian information criteria (BIC) were used to test the prediction power of each tool for EQ-5D VAS...
December 8, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29206898/somatic-mutation-footprinting-reveals-a-unique-tetra-nucleotide-signature-associated-with-intron-exon-boundaries-in-lung-cancer
#19
Samuel Wormald, Anita Lerch, Dmitri Mouradov, Liam O'Connor
Cigarette smoke comprises a large number of carcinogenic substances that can increase DNA mutation load in epithelial cells of the mouth, throat and lungs. While a strong C:A substitution preference is abundant in tobacco-related cancer genomes, detection of complex or less abundant somatic mutation signatures may be confounded by the heterogeneity of carcinogens present in smoke. Tri-nucleotide signatures are defined for a variety of somatic mutation processes, yet the extent to which this configuration optimally defines and discriminates between mutational processes is not clear...
December 1, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/29206324/ahns-series-do-you-know-your-guidelines-evidence-based-management-of-oral-cavity-cancers
#20
Amarbir Gill, Nilesh Vasan, Babak Givi, Arjun Joshi
Oral cavity squamous cell carcinoma (OCSCC) is the most common nonmelanoma head and neck cancer in the world, with an estimated 405 000 new cases expected each year. Subsites of the oral cavity include the alveolar ridge, buccal mucosa, anterior tongue, tonsillar pillar, retromolar trigone, hard palate, gingiva, and floor of the mouth. In this issue of the AHNS "Do you know your guidelines?" series, we review the evidence-based approach to the management of oral cavity carcinomas based on the framework provided by the National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines in Oncology...
December 5, 2017: Head & Neck
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