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https://www.readbyqxmd.com/read/29221316/recent-advances-in-the-management-of-pulmonary-tuberculoma-with-focus-on-the-use-of-tubeless-video-assisted-thoracoscopic-surgery
#1
REVIEW
Zhaohua Xia, Kun Qiao, Jianxing He
Pulmonary tuberculoma are benign solitary pulmonary nodules representing up to 25% of all resected solitary pulmonary nodules. However, the differentiation between pulmonary tuberculoma and lung cancer, as well as between active tuberculoma and inactive tuberculoma remains a clinical challenge. The present review summarizes the recent advances in the management of pulmonary tuberculoma, including radiological findings, the response to anti-tuberculosis treatment and surgical treatments. Application of the novel tubeless video-assisted thoracoscopic surgery (VATS) technique in both the diagnosis and treatment of pulmonary tuberculoma has been found to be safe and feasible and leads to less surgical trauma, which results in reduced length of hospitalization and better post-operative quality of life...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29218743/repeatability-of-pleural-adenosine-deaminase-measurements-in-diagnostic-evaluation-of-pleural-effusions
#2
Ourania S Kotsiou, Panagiota Tzortzi, Rafailia A A Beta, Athanasios Kyritsis, Konstantinos I Gourgoulianis
BACKGROUND: A follow-up thoracentesis is proposed in suspected atypical tuberculosis cases. The study aimed to define the variability of pleural ADA values across repeated thoracenteses in different types of pleural effusions (PEs) and to evaluate whether ADA variance, in regard to the cutoff value of 40 U/L, affected final diagnosis. METHODS: A total of 131 patients with PEs of various etiologies underwent three repeated thoracenteses. ADA values were subsequently estimated...
December 7, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29218392/unusual-circumstances-to-diagnose-cervical-pott-s-disease
#3
Mohamed Ali Kedous, Ahmed Msakni, Wael Chebbi, Mourad Zaraa, Mohsen Trabelsi
Tuberculous spondylodiscitis usually affects the dorso-lumbar spine, and its cervical location is a rare condition that can mimic other diseases and consequently cause treatment delays. We report a case of tuberculous spondylodiscitis of the lower cervical spine discovered under unusual circumstances in a patient with severe polytrauma involving a cranio-cerebral trauma, a non-displaced fracture of the two laminæ and the spinous process of the C6 vertebrae as well as fibular and tibial shaft fractures. The patient underwent static tibial nailing, and a collar with occipital and chin supports was applied...
December 7, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/29218257/pulmonary-tuberculosis-versus-recurrent-chemotherapy-induced-pneumonitis-a-clinical-dilemma
#4
Gulrayz Ahmed, Muhammad W Saif
Chemotherapy-induced lung toxicity can affect pulmonary parenchyma, pleura, airways, pulmonary vascular system, mediastinum or the neuromuscular system that is responsible for respiration. Chemotherapy-induced pulmonary toxicity is a diagnosis of exclusion. When the patients with malignancies develop pulmonary toxicity such as pneumonitis and distinguishing it from alternative diseases such as infectious, thrombotic, cardiac, malignant or exacerbation of chronic lung conditions can be difficult. Moreover, such patients are often immunosuppressed, physically stressed from the underlying disease and the cancer treatment and hence, more susceptible to usual and unusual or opportunistic infections...
October 4, 2017: Curēus
https://www.readbyqxmd.com/read/29217950/agreement-between-direct-fluorescent-microscopy-and-ziehl-neelsen-concentration-techniques-in-detection-of-pulmonary-tuberculosis-in-northwest-ethiopia
#5
Meseret Workineh, Mandie Maru, Ibrahim Seman, Ziyadu Bezu, Markos Negash, Mulugeta Melku, Addisu Gize, Agumas Shibabaw
Background: The sensitivity of smear microscopy for diagnosis of tuberculosis might be improved through treatment of sputum with sodium hypochlorite and application of fluorescent microscopy. This study aimed to determine the agreement between direct Fluorescent Microscopy and Ziehl-Neelsen concentration technique by their ability of detecting acid fast bacilli in resource poor settings. Methods: A cross sectional study was conducted at Gondar University Referral Hospital, Northwest Ethiopia...
September 2017: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/29217910/primary-tubercular-abscess-of-the-axilla-a-rare-case
#6
Ameet Kumar, T S Ramakrishnan, Samaresh Sahu
Tuberculosis can be broadly classified as pulmonary and extrapulmonary. Though pulmonary tuberculosis is the most common presentation, extrapulmonary tuberculosis is also an important entity. A tubercular cold abscess secondary to involvement of an adjacent bone or suppuration of lymph nodes is a well-known entity; however, a primary cold abscess is rare. We report a case of a young girl who presented with an axillary swelling which turned out to be a primary tubercular abscess of the axilla. To the best of our knowledge, this is the first reported case of a primary tubercular abscess presenting in the axilla...
December 2017: Indian Journal of Surgery
https://www.readbyqxmd.com/read/29216875/pulmonary-inflammatory-myofibroblastic-tumor-indistinguishable-from-tuberculosis-a-case-report-in-a-five-year-old-child-with-hemoptysis
#7
Tao Zuo, Jun Fu, Zhengyi Ni, Baojun Chen
BACKGROUND: Pulmonary inflammatory myofibroblastic tumor (PIMT) is a rare disease in China and its incidence is much lower than that of tuberculosis. PIMT accounts for only 0.04-1.2% of all lung tumors. PIMT can occurs in any age and nearly every part of the body. The clinical symptoms and radiological features of PIMT are nonspecific. Diagnosis is only made on the basis of histopathologic or immunohistochemical evaluation of the postoperation resected tissue. The therapeutic approach to PIMT should rely mainly on complete surgical resection...
December 8, 2017: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29216851/what-does-igra-testing-add-to-the-diagnosis-of-ocular-tuberculosis-a-bayesian-latent-class-analysis
#8
Rupesh Agrawal, Robert Grant, Bhaskar Gupta, Dinesh Visva Gunasekeran, Julio J Gonzalez-Lopez, Peter K F Addison, Mark Westcott, Carlos E Pavesio
BACKGROUND: To evaluate the contribution made to the diagnostic work-up for patients with suspected ocular tuberculosis (TB) by QuantiFERON-TB Gold In-Tube (QFT) tests using latent class analysis model. METHODS: A single centre retrospective cohort study. A Bayesian latent class model was constructed on the basis of demographics, phenotypes and test results from patients attending a tertiary referral center in the UK. This estimated the probability of ocular TB for each patient in two versions, first with and then without QFT...
December 8, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/29216277/immune-mediated-inflammatory-diseases-differently-affect-igras-accuracy-for-latent-tuberculosis-infection-diagnosis-in-clinical-practice
#9
Irene Latorre, Sonia Mínguez, José-Manuel Carrascosa, Juan Naves, Raquel Villar-Hernández, Beatriz Muriel, Cristina Prat, Esther García-García, Irma Casas, Eugeni Domènech, Carlos Ferrándiz, Lourdes Mateo, Jose Domínguez
BACKGROUND: Clinical accuracy of IGRAs remains unclear on patients with immune-mediated inflammatory diseases (IMIDs). Here, we assess the impact of immunosuppressants and IMIDs on QuantiFERON-TB Gold In-Tube (QFN-G-IT) and T-SPOT.TB accuracy. METHODS: Patients with IMIDs who required latent tuberculosis infection (LTBI) screening were enrolled and classified into: (i) 50 patients with inflammatory rheumatic diseases, (ii) 50 patients with psoriasis and (iii) 30 patients with Crohn's disease...
2017: PloS One
https://www.readbyqxmd.com/read/29216262/direct-detection-of-mycobacterium-tuberculosis-rifampin-resistance-in-bio-safe-stained-sputum-smears
#10
Surabhi Lavania, Divya Anthwal, Manpreet Bhalla, Nagendra Singh, Sagarika Haldar, Jaya Sivaswami Tyagi
Direct smear microscopy of sputum forms the mainstay of TB diagnosis in resource-limited settings. Stained sputum smear slides can serve as a ready-made resource to transport sputum for molecular drug susceptibility testing. However, bio-safety is a major concern during transport of sputum/stained slides and for laboratory workers engaged in processing Mycobacterium tuberculosis infected sputum specimens. In this study, a bio-safe USP (Universal Sample Processing) concentration-based sputum processing method (Bio-safe method) was assessed on 87 M...
2017: PloS One
https://www.readbyqxmd.com/read/29216193/community-prevalence-of-chronic-respiratory-symptoms-in-rural-malawi-implications-for-policy
#11
Hastings T Banda, Rachael Thomson, Kevin Mortimer, George A F Bello, Grace B Mbera, Rasmus Malmborg, Brian Faragher, S Bertel Squire
BACKGROUND: No community prevalence studies have been done on chronic respiratory symptoms of cough, wheezing and shortness of breath in adult rural populations in Malawi. Case detection rates of tuberculosis (TB) and chronic airways disease are low in resource-poor primary health care facilities. OBJECTIVE: To understand the prevalence of chronic respiratory symptoms and recorded diagnoses of TB in rural Malawian adults in order to improve case detection and management of these diseases...
2017: PloS One
https://www.readbyqxmd.com/read/29215188/pcr-test-in-induced-sputum-of-patients-with-pulmonary-tuberculosis
#12
Verônica da Silva Paiva, Fernanda Luiza Staub, Dirceu Felipe Valentini, Regina Bones Barcellos, Karen Barros Schmid, Elis Regina Dalla Costa, Maria Lucia Rosa Rossetti, Paulo de Tarso Roth Dalcin, Denise Rossato Silva
INTRODUCTION: Induced sputum (IS) is an alternative method of obtaining sputum, but IS smears are frequently negative. Culture is more time-consuming in its results, and less useful to guide the diagnosis. Polymerase chain reaction (PCR) is the most common methodology for rapid diagnosis of TB, and few studies evaluated its role in IS samples. OBJECTIVES: The objective of this study is to determine the diagnostic yield of PCR for TB compared with culture in IS samples...
December 7, 2017: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29214755/comparative-evaluation-of-the-loop-mediated-isothermal-amplification-assay-for-detecting-pulmonary-tuberculosis
#13
Chang Ki Kim, Eun A Cho, Dong Mi Shin, Sung Won Choi, So Youn Shin
BACKGROUND: Early detection of tuberculosis (TB) is challenging in resource-poor settings because of limited accessibility to molecular diagnostics. The aim of this study was to evaluate the performance of the loop-mediated isothermal amplification kit (TB-LAMP) for TB diagnosis compared with conventional and molecular tests. METHODS: A total of 290 consecutive sputum samples were collected from May till September, 2015. All samples were processed using the N-Acetyl-L-cysteine (NALC) NaOH method and tested by smear microscopy, solid and liquid culture, real-time PCR, and TB-LAMP...
March 2018: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/29211183/survival-of-patients-with-aids-and-co-infection-with-the-tuberculosis-bacillus-in-the-south-and-southeast-regions-of-brazil
#14
Márcio Cristiano de Melo, Maria Rita Donalisio, Ricardo Carlos Cordeiro
The study investigates the survival of patients with co-infection AIDS-TB through a retrospective study of a cohort of individuals aged 13 or more and the diagnosis of AIDS reported in the years 1998-99 and following 10 years. Of the 2,091 AIDS cases, 517 (24.7%) had positive diagnosis for tuberculosis, and 379 (73.3%) were male. The risk among co-infected patients was 1,65 times the not co-infected. Have been compared the exposed and non-exposed through the Kaplan-Meier and Cox method. The variables associated with longer survival were: female gender (HR = 0...
November 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/29209953/diagnostic-value-of-99mtc-ethambutol-scintigraphy-in-tuberculosis-compared-to-microbiological-and-histopathological-tests
#15
A H S Kartamihardja, Y Kurniawati, R Gunawan
OBJECTIVE: Tuberculosis (TB) still remains the world's endemic infection. TB affects the lungs and any part of the body other than the lung. The diagnosis of TB has not changed much over the decades. Ethambutol is one of the first line treatments for TB. It can be labeled using 99mTc. 99mTc-ethambutol will be accumulated in the site of TB lesion and can be imaged using gamma camera. The aim of this study was to evaluate the diagnostic value of 99mTc-ethambutol scintigraphy in detecting and localizing of TB...
December 5, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/29208880/comparative-yielding-of-bactec-mgit-960-and-genexpert-mtb-rif-assay-for-rapid-diagnosis-of-drug-resistance-tuberculosis-from-sputum-specimen
#16
N Laskar, M A Hossain, S A Nasreen, S M Kamal, S Roy, F Nahar, M Rahman, T K Barman
Among communicable disease, tuberculosis is the second leading cause of death worldwide, killing nearly two million people each year. Several diagnostic techniques are currently used to detect mycobacteria in respiratory specimens. Therefore an alternative, rapid and most effective method is required for diagnosis of pulmonary tuberculosis which is relatively more sensitive and specific. A total of 107 sputum samples of suspected TB patients were enrolled attending the National Tuberculosis Reference Laboratory (NTRL), Mohakhali, Dhaka, Bangladesh from July 2014 to July 2015...
October 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29208371/integrated-semi-targeted-metabolomics-analysis-reveals-distinct-metabolic-dysregulation-in-pleural-effusion-caused-by-tuberculosis-and-malignancy
#17
Nanying Che, Yan Ma, Huabin Ruan, Lina Xu, Xueying Wang, Xinting Yang, Xiaohui Liu
BACKGROUND: Tuberculous pleural effusion (TPE) and malignant pleural effusion (MPE) are the 2 most frequent causes of exudative pleural effusions (PEs). However, the clinical differentiation is challenging. METHODS: Metabolic signatures in pleural effusion from 156 patients were profiled. An integrated semi-targeted metabolomics platform was incorporated for high throughput metabolite identification and quantitation. In this platform, orbitrap based mass spectrometry with data dependent MS/MS acquisition was applied in the analysis...
December 2, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29208074/the-impact-of-implementing-a-xpert-mtb-rif-algorithm-on-drug-sensitive-pulmonary-tuberculosis-a-retrospective-analysis
#18
K Rees, N Muditambi, M Maswanganyi, J Railton, J A McIntyre, H E Struthers, P B Fourie, R P H Peters
Xpert MTB/RIF (Xpert) is the preferred first-line test for all persons with tuberculosis (TB) symptoms in South Africa in line with a diagnostic algorithm. This study evaluates pre- and post-implementation trends in diagnostic practices for drug-sensitive, pulmonary TB in adults in an operational setting, following the introduction of the Xpert-based algorithm. We retrospectively analysed data from the national TB database for Greater Tzaneen sub-district, Limpopo Province. Trends in a number of cases, diagnosis and outcome and characteristics associated with death are reported...
December 6, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/29207803/radiological-manifestations-of-pulmonary-tuberculosis-a-comparative-study-between-immunocompromised-and-immunocompetent-patients
#19
Manoj Mathur, Rajesh K Badhan, Sudesh Kumari, Navkiran Kaur, Saryu Gupta
Introduction: Pulmonary tuberculosis has atypical radiological manifestations in patients with underlying immunocompromised disease like diabetes and human immunodeficient virus infection. Computed tomography has important role in such patients for early diagnosis of disease and management to minimize complication. Aim: To evaluate and compare the computed tomography chest features of pulmonary tuberculosis in between immunocompromised patients and immunocompetent patients...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29207771/aspects-of-evolving-genito-urinary-tuberculosis-a-profile-of-genito-urinary-tuberculosis-gutb-in-110-patients
#20
Sriram Krishnamoorthy, Velmurugan Palaniyandi, Natarajan Kumaresan, Sivasankar Govindaraju, Jayaganesh Rajasekaran, Ilangovan Murugappan, Venkat Ramanan, Muthulatha Navaneetha Krishnan
Introduction: Genito Urinary Tuberculosis (GUTB) is a widespread disease seen in urology practice. The true incidence and prevalence of GUTB is difficult to estimate because a large number of patients remain asymptomatic. Aim: To recognize typical and atypical clinical and radiological features of tuberculosis and to emphasize the need for diagnosing GUTB early. Materials and Methods: This was a retrospective study conducted in 110 cases of GUTB diagnosed and treated in two teaching institutions over a period of three years, from July 2002 to June 2005...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
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