Gaku Wagai, Masao Togao, Takashi Kurakawa, Haruka Nishizaki, Jun Otsuka, Yuki Ohta-Takada, Akinobu Kurita, Tomo Suzuki, Koji Kawakami
BACKGROUND: Gastrointestinal transit (GIT) is influenced by factors including diet, medications, genetics, and gut microbiota, with slow GIT potentially indicating a functional disorder linked to conditions, such as constipation. Although GIT studies have utilized various animal models, few effectively model spontaneous slow GIT. AIMS: We aimed to characterize the GIT phenotype of CFP/Yit (CFP), an inbred mouse strain with suggested slow GIT. METHODS: Female and male CFP mice were compared to Crl:CD1 (ICR) mice in GIT and assessed based on oral gavage of fluorescent-labeled 70-kDa dextran, feed intake, fecal amount, and fecal water content...
April 15, 2024: Digestive Diseases and Sciences