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https://www.readbyqxmd.com/read/29773449/primary-bone-tumors-and-tumor-like-lesions-of-the-ulna
#1
Osman Emre Aycan, Sami Sökücü, Devrim Özer, Engin Çetinkaya, Yavuz Arıkan, Yavuz Selim Kabukçuoğlu
OBJECTIVE: The aim of this study was to discuss the diagnosis and surgical management and their results according to stage of primary bone tumors at ulna and to share our experience on this exceptional location for bone tumors. METHODS: We have retrospectively reviewed our clinics database and identified 23 cases (14 males and 9 females, mean age was 28.9 (range 4-77)) with primary bone tumors and tumor like lesion involvement of ulna. The patients were evaluated according to complaints, type and grade of tumor, treatment, recurrence and functional status...
May 14, 2018: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/29772622/-delay-in-high-grade-metastatic-prostate-cancer-progression-by-dutasteride-a-case-report
#2
Yuya Yamada, Hiroshi Fujiwara, Shinya Somiya, Shohei Fujikawa, Yuki Kamiyama, Masahiro Tamaki, Toshio Kanaoka
An 84-year-old man was referred to our hospital with swollen right cervical lymph nodes. Computed tomography showed right supraclavicular and mediastinal lymph node enlargement, and fluorodeoxyglucose positronemissiontomography showed multiple areas of abnormally increased radioactivity inthe right supraclavicular and mediastinal lymph nodes, right ninth rib, and left fifth and seventh ribs. Biopsy of the right supraclavicular lymph node revealed metastatic adenocarcinoma with partial immunohistochemical staining for prostate specific antigen (PSA)...
April 2018: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/29765952/malignant-orbital-meningioma-originating-from-the-frontal-lobe
#3
Giancarlo A Garcia, Andrew E Choy, Anton N Hasso, Don S Minckler
Purpose of the Study: Orbital meningiomas are typically benign tumors, most commonly originating from the dura of the sphenoid wing or the optic nerve sheath. Procedures: We describe an unusual case of a malignant meningioma originating from the frontal lobe that ultimately produced orbital and distant metastases. Results and Conclusions: Orbital invasion by the meningioma was preceded by multiple incomplete resections, which may have facilitated access to the orbit...
April 2018: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29764791/giant-cell-tumor-of-the-temporal-bone-and-skull-base-a-case-report
#4
İsa Kaya, Murat Benzer, Göksel Turhal, Gode Sercan, Cem Bilgen, Tayfun Kirazlı
Giant cell tumor (GCT) is a benign tumor that originates from undifferentiated mesenchymal cells of the bone marrow. The cranium as well as temporal bone is a rare location for GCTs. Despite its benign nature, GCT may be locally aggressive and has the potential to recur locally. Furthermore, GCT may give rise to pulmonary metastases (~1%) in addition to causing local bone destruction. Surgical excision is the treatment of choice for patients with GCT. We describe the case of a 56-year-old female who presented with headache and hearing loss with extensive GCT, which originated in the squamous part of the temporal bone and extended into the left mandibular fossa and middle ear...
April 2018: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/29762195/functional-outcomes-and-complications-after-oncologic-reconstruction-of-the-proximal-humerus
#5
Sjoerd Nota, Teun Teunis, Joost Kortlever, Marco Ferrone, John Ready, Mark Gebhardt, Kevin Raskin, Francis Hornicek, Joseph Schwab, Santiago Lozano Calderon
BACKGROUND: No consensus exists on the best method of articular reconstruction in patients who require proximal humerus resection for the management of primary bone sarcomas, soft-tissue sarcomas extending into the bone, benign and locally aggressive primary bone tumors, and metastatic disease. METHODS: We identified patients from two institutions who underwent wide resection of the proximal humerus along with oncologic reconstruction using osteoarticular allografts (OAs), endoprostheses, or allograft-prosthesis composites...
June 1, 2018: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/29753895/infected-intradural-dermoid-cyst-with-complete-dermal-sinus-of-posterior-fossa
#6
Félix K K Ségbédji, A J Tokpo, A A Nubukpo-Guménu, N K Alaoui, L M A Quenum, K Chakour, M F Chaoui, M Benzagmout
BACKGROUND: Intracranial dermoid cysts represent benign embryologic tumors. Children and young adults are most affected. Infected intradural dermoid cyst with complete dermal sinus of posterior fossa is exceptional. The main feature of this dermal sinus leads from the midline intradural cyst through an opening in the occipital bone to be attached to the skin. METHOD: We report two cases of infected intradural dermoid cyst with complete dermal sinus of posterior fossa in children, with special attention to the clinical, anatomical features of this rare combination...
May 10, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29753697/giant-dentinogenic-ghost-cell-tumor-a-case-report
#7
Ciro Dantas Soares, Roman Carlos, Thayná Melo de Lima Morais, Oslei Paes de Almeida
Dentinogenic ghost cell tumor (DGCT), a rare, benign odontogenic tumor with aggressive behavior, causes bone destruction and cortical expansion. We report here a case of DGCT in a 38-year-old male, presenting with enormous extraoral protrusion, which radiographically was predominantly radiolucent with radiopaque areas. Microscopically, it was observed to be a solid ameloblastomatous proliferation with pseudoglandular structures associated with clusters of ghost cells. Abundant dentinoid material adjacent to the epithelial sheets containing entrapped epithelial tumor cells was also evident...
April 18, 2018: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/29746513/role-of-18f-fdg-pet-ct-in-patients-without-known-primary-malignancy-with-skeletal-lesions-suspicious-for-cancer-metastasis
#8
Soo Bin Park, Jung Mi Park, Seung Hwan Moon, Young Seok Cho, Jong-Mu Sun, Byung-Tae Kim, Kyung-Han Lee
BACKGROUND: When subjects without a known malignancy present with suspicious skeletal lesions, differential diagnosis and primary cancer identification is important. Here, we investigated the role of FDG PET/CT in this clinical situation. METHODS: We enrolled 103 patients with no known malignancies who were referred for FDG PET/CT because of bone lesions that were suspicious for cancer metastasis. Each extra-skeletal FDG lesion was categorized as consistent with primary cancer or with metastasis based on the distribution and pattern of all abnormal lesions in the individual...
2018: PloS One
https://www.readbyqxmd.com/read/29741741/microsurgical-resection-of-glomus-jugulare-tumors-with-facial-nerve-reconstruction-3-dimensional-operative-video
#9
Duarte N C Cândido, Jean Gonçalves de Oliveira, Luis A B Borba
Paragangliomas are tumors originating from the paraganglionic system (autonomic nervous system), mostly found at the region around the jugular bulb, for which reason they are also termed glomus jugulare tumors (GJT). Although these lesions appear to be histologically benign, clinically they present with great morbidity, especially due to invasion of nearby structures such as the lower cranial nerves. These are challenging tumors, as they need complex approaches and great knowledge of the skull base. We present the case of a 31-year-old woman, operated by the senior author, with a 1-year history of tinnitus, vertigo, and progressive hearing loss, that evolved with facial nerve palsy (House-Brackmann IV) 2 months before surgery...
May 8, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29740534/genomic-dna-methylation-derived-algorithm-enables-accurate-detection-of-malignant-prostate-tissues
#10
Erfan Aref-Eshghi, Laila C Schenkel, Peter Ainsworth, Hanxin Lin, David I Rodenhiser, Jean-Claude Cutz, Bekim Sadikovic
Introduction: The current methodology involving diagnosis of prostate cancer (PCa) relies on the pathology examination of prostate needle biopsies, a method with high false negative rates partly due to temporospatial, molecular, and morphological heterogeneity of prostate adenocarcinoma. It is postulated that molecular markers have a potential to assign diagnosis to a considerable portion of undetected prostate tumors. This study examines the genome-wide DNA methylation changes in PCa in search of genomic markers for the development of a diagnostic algorithm for PCa screening...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29733987/use-of-bone-morphogenetic-protein-2-in-vertebral-column-tumor-surgery-a-national-investigation
#11
Rafael De la Garza Ramos, Jonathan Nakhla, Murray Echt, Yaroslav Gelfand, David J Altschul, Woojin Cho, Merrit D Kinon, Reza Yassari
OBJECTIVE: To report the rate of bone morphogenetic protein-2 (BMP-2) use in vertebral column tumor surgery. METHODS: The Nationwide Inpatient Sample database (2012-2014) was queried to identify patients who underwent spinal fusion for vertebral column tumors (primary benign, primary malignant, or metastatic). The rate of BMP-2 use was calculated and patient/operative factors associated with its use were also investigated. RESULTS: A total of 9,375 patients who underwent fusion surgery for spinal tumors between 2012 and 2014 were identified, with 540 cases using BMP-2 (5...
May 4, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29724496/how-to-diagnose-enchondroma-bone-infarct-and-chondrosarcoma
#12
REVIEW
Michael E Mulligan
Enchondromas are among the most common benign tumors seen in the skeleton. They are encountered frequently in routine clinical practice. The purpose of this review is to help radiologists confidently diagnose enchondroma and distinguish it from other entities, such as bone infarct, bone graft, and low-grade chondrosarcoma.
April 6, 2018: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/29720005/pulmonary-mycobacterial-spindle-cell-pseudotumor-a-report-of-3-cases-including-a-practical-approach-to-histopathologic-recognition-of-this-unusual-entity
#13
Katherine E Boylan, Brandon T Larsen, Brittany A Young, Erinn Downs-Kelly, Tanmay S Panchabhai, Earle S Collum, Leif Jensen, Lyska L Emerson
Mycobacterial spindle cell pseudotumor (MSP) is a rare benign spindle cell lesion containing acid-fact mycobacteria. These lesions are most commonly identified in the lymph nodes, skin, spleen, or bone marrow of immunocompromised patients and only rarely involve the lungs. We report 3 cases of pulmonary MSP, which include 2 patients who are known to be HIV-positive. The histopathological diagnosis of MSP in the lung lends itself to many challenges due to its rare incidence and its spindled tumor-like appearance...
May 1, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29719850/delayed-progressive-intraparenchymal-tension-pneumocephalus-after-craniotomy-for-recurrent-pituitary-macroadenoma-a-case-report
#14
Samer S Hoz, Khatab Baban, Mohamad Sabah, Awfa Aktham, Alexis Rafael Narvaez-Rojas, Luis Rafael Moscote-Salazar
Pneumocephalus is defined as the presence of air in the intracranial cavity. In most cases, its evolution is asymptomatic and benign. Pneumocephalus post-surgery is a frequent complication of cranial surgery. We herein report delayed tension pneumocephalus after craniotomy for pituitary macroadenoma. A 73-year-old man with recurrent pituitary macroadenoma underwent subtotal resection via subfrontal approach. The postoperative course was uneventful and the patients regained his normal daily living activities...
April 2018: Bulletin of Emergency and Trauma
https://www.readbyqxmd.com/read/29715136/calcium-phosphate-cement-in-the-surgical-management-of-benign-bone-tumors
#15
Takashi Higuchi, Norio Yamamoto, Katsuhiro Hayashi, Akihiko Takeuchi, Hiroaki Kimura, Shinji Miwa, Kentaro Igarashi, Kensaku Abe, Yuta Taniguchi, Hisaki Aiba, Hiroyuki Tsuchiya
BACKGROUND/AIM: This study assessed the mid- to long-term outcomes of calcium phosphate cement (CPC) implantation in benign bone tumor surgery. PATIENTS AND METHODS: Between 2000 and 2015, 130 patients underwent CPC implantation in benign bone tumor surgery. Radiographic findings and clinical outcomes were retrospectively evaluated. RESULTS: The mean follow-up period was 52 months. CPC filling immediately after surgery was sufficient, regardless of the amount of CPC used and the usage of adjuvant substances, which resulted in 92% of the patients' radiological results being classified as good or excellent...
May 2018: Anticancer Research
https://www.readbyqxmd.com/read/29710674/norcantharidin-modulates-the-mir-30a-metadherin-akt-signaling-axis-to-suppress-proliferation-and-metastasis-of-stromal-tumor-cells-in-giant-cell-tumor-of-bone
#16
Feiyan Chen, Siqun Wang, Yibing Wei, Jianguo Wu, Gangyong Huang, Jie Chen, Jingsheng Shi, Jun Xia
Giant cell tumor of bone (GCTB) is a benign but locally aggressive tumor, which can cause significant bone destruction at the epiphysis of long bones. Recent studies have demonstrated that norcantharidin (NCTD) can inhibit the proliferation and migration of various human cancer cells, but the role of NCTD in GCTB has not previously been evaluated. The aim of this study was to explore the nature of the anti-cancer effects of NCTD in GCTB and to elucidate the biomolecular mechanisms responsible for these effects...
April 26, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29702979/chondroblastoma-of-the-distal-femoral-metaphysis-a-case-report-with-emphasis-on-imaging-findings-and-differential-diagnosis
#17
Fang Wang, Jizhen Li, Dexin Yu, Qing Wang
Chondroblastoma is a rare benign tumor, consisting of tissue resembling foetal cartilage, and arising in the epiphyses, or apophyses of long tubular bone. However, chondroblastoma of the cortex of the long bone metaphysis is extremely rare.A 15-year-old girl presented a 10-month history of intermittent knee pain and without mobility limitation. X ray, computed tomography (CT), and magnetic resonance imaging (MRI) showed a slightly expansile lytic lesion involving the metaphyseal cortex of the left distal femur...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29693784/meta-analysis-of-the-incidence-and-patterns-of-second-neoplasms-after-photon-craniospinal-irradiation-in-children-with-medulloblastoma
#18
Abhishek Bavle, Sayani Tewari, Amy Sisson, Murali Chintagumpala, Michael Anderson, Arnold C Paulino
BACKGROUND: Second neoplasms (SNs) are a well-established long-term adverse effect of radiation therapy (RT), but there are limited data regarding their incidence and location relative to the radiation field, specific to medulloblastoma (MB) survivors after craniospinal irradiation (CSI). METHODS: A systematic literature review, per Preferred Reporting Items for Systematic Reviews and Meta-Analyses, identified six studies reporting the incidence and locations of SNs for 1,114 patients with MB, after CSI, with a median follow-up of ∼9 years (7...
April 25, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29682262/unicystic-ameloblastoma-rehabilitation-with-chin-graft-harvested-and-implant-supported-fixed-prosthesis
#19
J Sanz-Alonso, N Martínez-Rodríguez, M Martín-Ares, C Barona-Dorado, J Cortés Bretón-Brinkmann, J M Martínez-González
Objective: The objective is to present a clinical case of a 38-year-old male with a maxillary unicystic ameloblastoma treated by means of tumor block resection followed by chin-harvested graft placement in order to place two dental implants for esthetic and functional rehabilitation. Methods: Ameloblastoma is a benign odontogenic tumor characterized by local aggression and a high rate of recurrence; the latter partly depends on how it is treated. Complete resection of the tumor, which usually prevents recurrence, produces bone defects of varying size that must be reconstructed later on...
October 2017: Oral & Implantology
https://www.readbyqxmd.com/read/29682051/meningioma-in-fourth-ventricle-of-brain-a-case-report-and-literature-review
#20
Firooz Salehpour, Javad Aghazadeh, Amir Mohammad Bazzazi, Farhad Mirzaei, Amir Taha Eftekhar Saadat, Seyed Ahmad Naseri Alavi
Meningiomas are benign tumors origin from central nervous system. They usually involve cephalic, paravertebral soft tissues, skin and in rare cases in the ear, temporal bone, mandible, foot, lung, and mediastinum. In this case, we report an unusual case of meningioma which placed in the fourth ventricle. A 14-year-old man with seizure and headache referred to our ward. The magnetic resonance imaging reported bilateral acoustic neuroma and fourth ventricle meningioma. The patient was scheduled for total tumor resection and the histopathology revealed psammomatous type of meningioma...
April 2018: Asian Journal of Neurosurgery
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