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https://www.readbyqxmd.com/read/28346486/grem1-is-expressed-in-the-cancer-associated-myofibroblasts-of-basal-cell-carcinomas
#1
Hye Sung Kim, Myung Soo Shin, Min Seok Cheon, Jae Wang Kim, Cheol Lee, Woo Ho Kim, Young Sill Kim, Bo Gun Jang
Cancer-associated fibroblasts (CAFs) play important roles in cancer progression through their complex interactions with cancer cells. The secreted bone morphogenetic protein antagonist, gremlin1 (GREM1) is expressed by the CAFs of basal cell carcinomas (BCCs), and promotes the growth of cancer cells. In this study, we investigated the expression of GREM1 mRNAs in various benign and malignant skin tumors, including various BCC subtypes. Analysis by RNA in situ hybridization (ISH) revealed that fibroblasts in the scar tissue expressed GREM1 and α-smooth muscle actin (α-SMA), whereas resident fibroblasts in the dermis of the normal skin did not express GREM1...
2017: PloS One
https://www.readbyqxmd.com/read/28346248/68ga-psma-pet-ct-in-osteosarcoma-in-fibrous-dysplasia
#2
Arun Sasikumar, Ajith Joy, M R A Pillai, Tony M Alex, Geetha Narayanan
Fibrous dysplasia (FD) is a benign bone lesion with a rare but potential for malignant transformation. Neither Tc-MDP nor F-FDG PET/CT can differentiate between FD and areas of malignant transformation in FD. We described a case of osteosarcoma developing in FD with selective uptake of tracer in malignant transformation areas demonstrated on a Ga-PSMA PET/CT scan. Our case highlights the ability of Ga-PSMA PET/CT to map tumor neoangiogenesis in osteosarcoma arising in FD, which can have potential implications in prognostication, possibility of antiangiogenesis-based therapeutic options, and in response assessment following chemotherapy...
March 24, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28344536/capitate-chondroblastoma-a-case-report-and-review-of-the-literature
#3
Ali Izadpanah, Riyam T Zreik, Thomas Shives, Sanjeev Kakar
Background: Chondroblastomas are benign tumors that typically occur in the epiphysis of long bones. Carpal bone chondroblastomas are very rare and are known to have less aggressive behavior with no evidence of recurrence reported. Methods: We present a case of a recurrent chondroblastoma in the capitate that was treated with repeat curettage, application of phenol, and bone grafting. Results: At 3 years post surgery, the patient is disease free with excellent functional return. Conclusion: Chondroblastomas are rare within the carpus...
March 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28337505/osteochondroma-causing-cervical-spinal-cord-compression
#4
Ryunosuke Fukushi, Makoto Emori, Noriyuki Iesato, Masanobu Kano, Toshihiko Yamashita
Osteochondromas are the most common benign tumors of the bone. They occur in young adolescent patients and are frequently located in the metaphyses of the long bones; they do not grow after skeletal maturity. The incidence of osteochondroma in the spine is reported to be rare. Moreover, patients with spinal osteochondroma who develop symptoms of myelopathy are extremely rare. We report the case of an 8-year-old girl who experienced myelopathy due to spinal compression of the cervical osteochondroma. This case suggests that if a cartilage cap is observed on the spinal canal with magnetic resonance imaging (MRI), the tumor may extend to the spinal canal, resulting in neurologic dysfunction...
March 23, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28324880/fine-needle-aspiration-cytology-of-diffuse-type-tenosynovial-giant-cell-tumors
#5
Zimin Zhao, Cherie Paquette, Akeesha A Shah, Kristen A Atkins, Henry F Frierson
BACKGROUND: Tenosynovial giant cell tumor (TSGCT), also known as giant cell tumor of tendon sheath or pigmented villonodular synovitis, is the most common benign tumor of the tendon and synovium. The intra-articular diffuse type can present as a large infiltrative mass involving adjacent soft tissue and sometimes causes secondary destruction of bone, which leads to radiographic and clinical concern for malignancy. The tumor may also be purely extra-articular. CASE: Here, we report the fine needle aspiration cytology findings of 2 cases of diffuse-type TSGCT with large mononuclear cells with eccentric nuclei, finely granular cytoplasm, and a peripheral well-defined cytoplasmic rim of hemosiderin ("ladybird cells")...
March 22, 2017: Acta Cytologica
https://www.readbyqxmd.com/read/28318171/-chondromyxoid-fibroma-of-the-mandible-a-case-report
#6
Zhou Ying, Zhang Zhihui, Sun Xiaojuan
Chondromyxoid fibroma (CMF) is a rare benign bone tumor. This tumor mostly affects the long bones of the appendicular skeleton but rarely grows in the craniofacial region. In this article, a case of CMF of the mandible was presented to enhance our understanding of CMF. Its clinical manifestations, imaging characteristics, and treatment methods were discussed by analyzing the related literature.
December 1, 2016: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28301321/giant-parathyroid-adenoma-associated-with-severe-hypercalcemia-in-an-adolescent-patient
#7
Kinyas Kartal, Nurcihan Aygun, Mujdat Bankaoglu, Alper Ozel, Mehmet Uludag
BACKGROUND: The objective of this study is to bring attention to the importance of differential diagnosis in adolescent patients with skeletal involvement and hypercalcemia. CASE: A 17-year-old male patient with a complaint of severe leg pain was admitted to our hospital. Seven months before he had a fracture of his distal humerus after falling on to his left shoulder and was treated conservatively. Five months previously, he had a rupture of his quadriceps tendon...
March 16, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28301222/qualitative-3-t-proton-mr-spectroscopy-for-the-characterization-of-musculoskeletal-neoplasms-update-on-diagnostic-performance-and-indications
#8
Pedro Augusto Gondim Teixeira, Maxime Ledrich, François Kauffmann, John Mbapte Wamba, Jacques Felblinger, Alain Blum, Gabriela Hossu
OBJECTIVE: The objective of our study was to evaluate the diagnostic performance of qualitative 3-T proton MR spectroscopy ((1)H-MRS) for the characterization of musculoskeletal neoplasms. SUBJECTS AND METHODS: Proton MRS studies of 74 patients (76 lesions) with a histologically confirmed musculoskeletal neoplasm or neoplasms were prospectively included in this study. All studies were performed using a 3-T MRI scanner. Spectra were analyzed with conventional MRI software provided by the fabricant and with dedicated independent MRS software...
March 16, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28294675/-tumor-of-posterior-mediastinum-rare-case-of-extramedullar-myelolipoma
#9
Tamás Zombori, Noémi Tóth, József Furák, Zsolt Berényi, László Tiszlavicz
CASE REPORT: A 71-year-old male with acute exacerbation of chronic bronchitis was treated in summer of 2015. The CT scan has revealed a mass on the right side of 11th thoracic vertebra in the adipose tissue with a sharp edge towards the lung and containing a small amount of contrast agent. The radiologist recommended histological sampling of the mass. The tumor was removed by Video-Assisted Thoracic Surgery (VATS) in August of 2015. The patient was discharged on the fifth postoperative day without complication...
March 2017: Magyar Sebészet
https://www.readbyqxmd.com/read/28289810/non-odontogenic-tumors-of-the-facial-bones-in-children-and-adolescents-role-of-multiparametric-imaging
#10
REVIEW
Minerva Becker, Salvatore Stefanelli, Anne-Laure Rougemont, Pierre Alexandre Poletti, Laura Merlini
Tumors of the pediatric facial skeleton represent a major challenge in clinical practice because they can lead to functional impairment, facial deformation, and long-term disfigurement. Their treatment often requires a multidisciplinary approach, and radiologists play a pivotal role in the diagnosis and management of these lesions. Although rare, pediatric tumors arising in the facial bones comprise a wide spectrum of benign and malignant lesions of osteogenic, fibrogenic, hematopoietic, neurogenic, or epithelial origin...
March 13, 2017: Neuroradiology
https://www.readbyqxmd.com/read/28286638/an-unusual-localization-of-intraosseous-schwannoma-the-hamate-bone
#11
Volkan Gurkan, Cavide Sonmez, Ayse Aralasmak, Fatih Yildiz, Ozgur Erdogan
Intraosseous schwannoma of the hamate bone presented in this case is a very rare benign tumor, and its diagnosis combined with clinical, imaging and needle biopsy is important to guide further therapy. The diagnosis of schwannoma of the hamate was proved histologically following its surgical treatment by curettage.
January 11, 2017: Clinics and Practice
https://www.readbyqxmd.com/read/28281551/molecular-correlates-and-rate-of-lymph-node-metastasis-of-non-invasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-and-invasive-follicular-variant-papillary-thyroid-carcinoma-the-impact-of-rigid-criteria-to-distinguish-non-invasive-follicular
#12
Uiju Cho, Ozgur Mete, Min-Hee Kim, Ja Seong Bae, Chan Kwon Jung
Thyroid tumors formerly classified as non-invasive encapsulated follicular variant of papillary thyroid carcinoma were recently renamed 'non-invasive follicular thyroid neoplasm with papillary-like nuclear features'. The current study investigated the frequency of lymph node metastasis and mutational profile of encapsulated follicular variant in the setting of a clinical practice where central neck dissection was the standard of practice. We defined the impact of rigid diagnostic criteria by regrouping such tumors based on the complete absence of papillae or presence of ≤1% papillae...
March 10, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28277479/aggressive-osteoblastoma-in-the-maxilla-unusual-lesion-in-the-craniofacial-skeleton
#13
Fued Samir Salmen, Marina Reis Oliveira, Cláudia Maria Navarro, Rogério Aparecido Dedivitis, Valfrido Antonio Pereira Filho, Mario Francisco Real Gabrielli
Osteoblastomas are benign bone tumors, which are unusual in the craniofacial skeleton, being most often observed in the axial skeleton and long bones. The most common site in the maxillofacial region is the mandible and the involvement of the maxilla and paranasal sinuses is extremely rare. Although it is a benign lesion, the aggressive variant raises concerns due to its huge local destructive potential and tendency to relapse. In this clinical case, an aggressive osteoblastoma is described in a 7-year-old patient...
March 8, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28276202/safety-osseointegration-and-bone-ingrowth-analysis-of-pmma-based-porous-cement-on-animal-metaphyseal-bone-defect-model
#14
Bruno Cimatti, Mariana Avelino Dos Santos, Maria Sol Brassesco, Laura Tiemi Okano, Wendell Monteiro Barboza, Marcello Henrique Nogueira-Barbosa, Edgard Eduard Engel
Bone defects created after curettage of benign bone tumors are customarily filled with solid poly(methyl methacrylate) (PMMA) or other bone substitutes. In this study, we depicted a porous PMMA-based cement (produced by mixing sodium bicarbonate and citric acid) and evaluated the prospect of its clinic application. Cement samples were characterized by high-performance liquid chromatography (HPLC) coupled to mass spectrometry and its cytotoxicity evaluated in fibroblast cultures. Implantation in rabbits allowed the histologic analysis of bone, kidneys, and liver for toxicity and coagulation tests, and MRI images for hemostasis evaluation...
March 9, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28272664/desmoplastic-fibroblastoma-in-maxillary-alveolar-bone-mimicking-an-odontogenic-lesion-a-novel-case-report-with-review-of-literature
#15
Zohreh Jaafari-Ashkavandi, Mehdi Yasamin Shirazi, Sepideh Assar
Desmoplastic fibroblastoma (Collagenous fibroma) is a rare benign soft tissue tumor that disseminates widely and can be intramuscular or subcutaneously. There are seven reported cases in the oral cavity so far. We reported a novel case of collagenous fibroma that has been found in the anterior part of maxilla in a 58-year-old woman as an intraosseous radiolucent lesion that has been discovered during routine radiography. Histopathologically, spindle and stellate-shaped fibroblasts in a collagen-rich stroma as well as binucleated and multinucleated fibroblasts with prominent nucleoli were seen...
February 4, 2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28272066/unusual-presentation-of-chondroblastoma-mimicking-trevor-s-disease
#16
Y Karkhur, A Tiwari, T Verma, L Maini
Chondroblastoma is a benign bone tumor, represents 1%-2% of all primary bone tumors, typically seen in patients 10-25-year-old and more common in males. It occurs most frequently in the distal femur, proximal tibia, and proximal humerus. Soft tissue extension is extremely rare. Adjacent joints may develop effusions, but the tumor mass protruding into the joint has never been seen in case of chondroblastoma. We report a rare case of intra-articular chondroblastoma arising from proximal tibia in a 16-year-old boy and growing into the knee joint mimicking an intra-articular osteochondroma...
March 3, 2017: Journal of Postgraduate Medicine
https://www.readbyqxmd.com/read/28268121/spontaneous-hemothorax-a-rare-face-of-vertebral-osteochondroma
#17
Sarah Sainte, Herbert Decaluwé, Peter Vanbrabant
BACKGROUND: Osteochondroma is the most common benign tumor of the bone. It is usually asymptomatic, but complications may result from mechanical injury to adjacent anatomic structures, such as the diaphragm and lung, when located intrathoracically. CASE REPORT: We report the unusual occurrence of a large hemothorax and lacerated right diaphragm in a 41-year-old woman caused by vertebral osteochondroma affecting the eleventh thoracic vertebra. Thoracoscopic exploration with resection of the osteochondroma and repair of the diaphragm was performed...
March 3, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28260005/clinical-significance-of-the-phosphorylation-of-mapk-and-protein-expression-of-cyclin-d1-in-human-osteosarcoma-tissues
#18
Jian Wu, Lei-Lei Cui, Jun Yuan, Yuan Wang, Shu Song
The aim of the present study was to investigate the significance of the phosphorylation of mitogen-activated protein kinase (MAPK) and the protein expression of cyclin D1 in human osteosarcoma tissues. Human osteosarcoma tissue samples were collected from 30 patients, benign bone tumor samples were collected from 30 patients, and normal bone tissues were collected from 10 individuals as controls. Immunohistochemistry was performed to measure the levels of phosphorylated (p)-MAPK and cyclin D1 protein in cases of human osteosarcoma...
April 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28258288/-giant-cell-reparative-granuloma-of-the-metacarpal-bone-diagnostic-difficulties
#19
Panajotis Telisselis, Guido Heers, Ernst Obernhuber
Giant cell reparative granuloma (GCRG) is benign, non-tumorous granulation tissue. It mainly arises in the jaw bone and occasionally in the hand and foot. Because of the high rate of recurrence, wide surgical resection and autologous bone grafting are recommended. However, this can be problematic for hand function. We present a case report of a 16-year-old boy with a GCRG of the fifth metacarpal bone and the diagnostic difficulties. To treat the patient, we performed a wide resection with the interposition of a corticocancellous bone graft and plate osteosynthesis...
March 3, 2017: Der Unfallchirurg
https://www.readbyqxmd.com/read/28252420/metaphyseal-cortical-defect-and-tumor-like-processes-of-long-bones-a-literature-review-and-own-observations
#20
N Lysenko, Ye Sharmazanova, I Voronzhev, A Sorochan, Yu Kolomiychenko
Metaphyseal cortical defect (metaphyseal fibrous defect, cortical fibrous defect) of the long bones is a quite common variant of the bone structure's pathologic changes. The cortical defects and similar to their tumor-like processes (non-ossifying fibroma, benign fibrous histiocytoma etc.) are characterized by particular qualities of the clinical symptoms and radiologic signs. The aim of this article is to analyze a known literature data about cortical fibrous defects of long bones and similar to their tumor-like processes and present results of our own observations...
January 2017: Georgian Medical News
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