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https://www.readbyqxmd.com/read/28913162/endobronchial-hamartoma-a-rare-structural-cause-of-chronic-cough
#1
Saman Ahmed, Ayesha Arshad, M Jeffery Mador
Pulmonary hamartomas are rare benign tumors consisting of multiple mesenchymal cell lines like cartilage, bone and fat. We discuss an interesting case of a 53-year-old male patient, who was referred to our clinic for persistent cough. Chest X-ray revealed a left suprahilar density associated with plate like atelectasis, which on chest CT was found to be a densely calcified nodule, causing narrowing of the left upper lobe (LUL) bronchus with calcified bilateral hilar lymph nodes. A bronchoscopy revealed a smooth endobronchial mass with calcification, which was removed...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28905737/giant-cell-tumor-of-bone-revisited
#2
Andreas F Mavrogenis, Vasileios G Igoumenou, Panayiotis D Megaloikonomos, Georgios N Panagopoulos, Panayiotis J Papagelopoulos, Panayotis N Soucacos
Giant cell tumor (GCT) of bone is a locally aggressive benign neoplasm that is associated with a large biological spectrum ranging from latent benign to highly recurrent and occasionally metastatic malignant bone tumor. It accounts for 4-10% of all bone tumors and typically affects the meta-epiphyseal region of long bones of young adults. The most common site involved is the distal femur, followed by the distal radius, sacrum, and proximal humerus. Clinical symptoms are nonspecific and may include local pain, swelling, and limited range of motion of the adjacent joint...
2017: SICOT-J
https://www.readbyqxmd.com/read/28888573/an-extradigital-glomus-tumor-of-the-median-antebrachial-vein
#3
Anthony R Andreoni, Jessica Waughtel, Jonathan Cook, Pablo A Bejarano, David Friedman
Glomus tumors are benign vascular neoplasms that arise from specialized dermal arteriovenous anastomoses called glomus bodies. These tumors are most often found in the digital pulp and subungual region of the fingertips; however, a review of the literature suggests that extradigital glomus tumors may occur more often than is generally recognized. Although most extradigital glomus tumors arise within subcutaneous tissues, glomus tumors have occasionally been found within bones, nerves, and blood vessels. An intravascular glomus tumor of the forearm is a very rare occurrence and only a few cases have been reported in the literature...
September 6, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28885439/multiple-recurrent-fibromatosis-with-cranial-fasciitis-characteristics-in-a-pediatric-patient
#4
Rui Dai, Irene J Pien, David A Brown, Andre Marshall, Herbert E Fuchs, Jeffrey R Marcus
Cranial fasciitis is a rare, rapidly growing, but benign fibroblastic tumor of the skull that generally presents in childhood. Local resection or curettage of the affected bone is generally curative and the tumor is thought not to recur. Cranial fasciitis is distinguished by positive cytoplasmic and nuclear beta-catenin staining. Fibromatosis is a clonal myofibroblastic nonmalignant proliferation that generally demonstrates positive nuclear beta-catenin staining. In this report, the authors present a patient with fibromatosis with cranial fasciitis characteristics in a 2...
September 6, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28884107/giant-cell-tumor-locally-advanced-around-the-knee-treatment-and-literature-review
#5
REVIEW
Ana Valeria Rigollino, Thiago Santos Fernando, Marcos Hajime Tanaka, Marcello Martins Souza
Giant cell tumor (GCT) is a benign bone tumor with aggressive characteristics. They are more prevalent in the third decade of life and demonstrate a preference for locating in the epiphyseal region of long bones. They have a high local recurrence rate, which depends on the type of treatment and initial tumor presentation. The risk of lung metastases is around 3%. Between October 2010 and August 2014, nine patients diagnosed with locally advanced GCT or with pathological fracture to the knee level underwent surgical treatment...
June 2017: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/28883682/role-of-mri-in-diagnosis-of-ruptured-intracranial-dermoid-cyst
#6
Sefedin Muçaj, Mehmet Sahin Ugurel, Kreshnike Dedushi, Naser Ramadani, Naim Jerliu
INTRODUCTION: Intracranial dermoid cystic tumors account for <1% of all intracranial masses. CASE REPORT: A 52-year-old male, having headaches, nausea and is presented with a history of 2 episodes of new onset seizures. On presentation, the patient had a normal physical exam, including a complete neurological and cranial nerve exam. METHODS: Precontrast MRI; TSE/T2Wsequence in axial/coronal planes; 3D - HI-resolution T1W sagittal; FLAIR/T2W axial; FLAIR/T2W, Flash/T2W oblique coronal plane, GRE/T2W axial...
June 2017: Acta Informatica Medica: AIM
https://www.readbyqxmd.com/read/28882712/joint-capsule-like-intracranial-osteochondroma-mimicking-cystic-meningioma
#7
Yusuke S Hori, Yuki Ebisudani, Mizuho Aoi
This report provides the first representative images of an intracranial osteochondroma with a cystic component mimicking cystic meningioma. A 40-year-old male presented at our outpatient clinic with decreased sensation in his right upper extremity. Preoperative computed tomography showed a tumor with a cystic-meningioma-like appearance and prominent calcifications. On magnetic resonance imaging, calcification of the lesion was suggested by the T2-weighted image; weak enhancement was seen on the T1-weighted image...
September 4, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28878541/an-unusual-localization-of-chondroblastoma-the-triradiate-cartilage-from-a-case-report-a-reconstructive-technique-proposal-with-imaging-evolution
#8
Carmine Zoccali, Francesco Arrigoni, Silvia Mariani, Federico Bruno, Antonio Barile, Carlo Masciocchi
INTRODUCTION: Chondroblastoma (also known as Codman tumor) is a rare intermediate grade cartilaginous neoplasm, representing less than 1% of all primary bone tumors; it characteristically arises in the epiphysis or apophysis of a long bone in young patients, predominantly males. The most frequent location of chondroblastoma is the humerus (70% incidence rate) and more rarely it is located in the pelvis. When it affects the hip, the triradiate cartilage is the most common site. MATERIALS AND METHODS: An unusual case of Chondroblastoma located in the triradiate cartilage is reported...
August 2017: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/28875382/-tumors-of-the-inner-ear-and-adjacent-structures
#9
REVIEW
J Schittenhelm
Tumors of the inner ear and adjacent structures often present with hearing loss, tinnitus and vertigo due to compression of the traversing cranial nerves. More than 90% of the tumors of the inner ear with or without expansion into the cerebellopontine angle are histologically diagnosed as vestibular schwannomas. Less common tumorous lesions include ectopic meningiomas located in the petrous bone, glomus tympanicum paragangliomas or endolymphatic sac tumors (ELST) originating in the vestibular recess. Most tumors are sporadic, but hereditary disorders have to be considered...
September 5, 2017: Der Pathologe
https://www.readbyqxmd.com/read/28875046/ganglioneuroma-of-the-external-auditory-canal-and-middle-ear
#10
Hesham Saleh Almofada, Michael Steven Timms, M Anas Dababo
OBJECTIVE: We report an extremely rare case of ganglioneuroma involving the external auditory canal and middle ear. CASE REPORT: Ganglioneuromas are rare benign mature tumors thought to originate from sympathetic ganglions, with the highest incidence in the retroperitoneum, adrenal medulla, and posterior mediastinum. We present a case of ganglioneuroma of the external auditory canal and middle ear. At the age of 12 months, the patient was diagnosed with neuroblastoma stage IV with metastasis to the squamous temporal bone, bone marrow, and skull base...
2017: Case Reports in Otolaryngology
https://www.readbyqxmd.com/read/28871082/stromal-and-epithelial-transcriptional-map-of-initiation-progression-and-metastatic-potential-of-human-prostate-cancer
#11
Svitlana Tyekucheva, Michaela Bowden, Clyde Bango, Francesca Giunchi, Ying Huang, Chensheng Zhou, Arrigo Bondi, Rosina Lis, Mieke Van Hemelrijck, Ove Andrén, Sven-Olof Andersson, R William Watson, Stephen Pennington, Stephen P Finn, Neil E Martin, Meir J Stampfer, Giovanni Parmigiani, Kathryn L Penney, Michelangelo Fiorentino, Lorelei A Mucci, Massimo Loda
While progression from normal prostatic epithelium to invasive cancer is driven by molecular alterations, tumor cells and cells in the cancer microenvironment are co-dependent and co-evolve. Few human studies to date have focused on stroma. Here, we performed gene expression profiling of laser capture microdissected normal non-neoplastic prostate epithelial tissue and compared it to non-transformed and neoplastic low-grade and high-grade prostate epithelial tissue from radical prostatectomies, each with its immediately surrounding stroma...
September 4, 2017: Nature Communications
https://www.readbyqxmd.com/read/28866093/mir-127-and-mir-376a-act-as-tumor-suppressors-by-in%C3%A2-vivo-targeting-of-coa1-and-pdia6-in-giant-cell-tumor-of-bone
#12
Ingrid Herr, Heiner Sähr, Zhefu Zhao, Libo Yin, Georg Omlor, Burkhard Lehner, Jörg Fellenberg
Giant cell tumors of bone (GCTB) are generally benign bone tumors associated with expansive osteolytic defects, a high rate of recurrence and potential malignant transformation. We recently observed silencing of miR-127-3p and miR-376a-3p in GCTB and identified COA1 and PDIA6 as their target genes. Here, we investigate the impact of these microRNAs and their target genes on tumor engraftment and progression of giant cell tumor stromal cells (GCTSC) in vivo by xenotransplantation on the chorioallantoic membrane of chicken eggs...
September 1, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28862793/fine-needle-aspiration-biopsy-of-lytic-bone-lesions-an-institution-s-experience
#13
Uday Shergill, Taisia Vitkovski, Guillaume Stoffels, Melissa Klein, Cecilia Gimenez, Alice Laser, Rubina Cocker, Karen Chau, Kasturi Das
OBJECTIVES: Fine needle aspiration (FNAB) is an effective, minimally-invasive, inexpensive, diagnostic technique. The objective of this study was to evaluate the accuracy of FNAB in the diagnosis of bone lesions. METHODS: FNABs of bone lesions diagnosed at our institution over a 2-year period were retrospectively analyzed. RESULTS: 241 samples were reviewed. Patients included 121 males and 120 females, with ages ranging from 4-95 years (mean = 66 years)...
September 1, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28856360/postpartum-treatment-of-metastatic-recurrent-giant-cell-tumor-of-capitate-bone-of-wrist
#14
Robert L Satcher, Vinod Ravi, Wei-Lien Wang, Scott Oates
Giant cell tumors (GCTs) are aggressive benign lesions that occur in the bone epiphysis. They are most often found in the long bones of the lower extremities. Wrist bone involvement is rare, capitate bone involvement exceedingly rare. Treatment in the wrist usually consists of excision, local adjuvant treatment, and cementing and/or bone grafting. GCTs also metastasize to the lungs; pulmonary lesions are excised and systemic therapy provided. We present the case of a 19-year-old woman with GCT of the capitate bone...
July 2017: American Journal of Orthopedics
https://www.readbyqxmd.com/read/28853064/receptor-activator-of-nuclear-transcription-factor-nf-%C3%AE%C2%BAb-rank-its-ligand-rankl-and-natural-inhibitor-of-rankl-osteoprotegerin-opg-in-the-blood-serum-of-patients-with-primary-bone-tumors
#15
N E Kushlinskii, E S Gershtein, Yu N Solov'ev, Yu S Timofeev, I V Babkina, A O Dolinkin, A A Zuev, O I Kostyleva
The content of components of the RANK/RANKL/OPG system, the key regulator of homeostasis in the bone tissue, in blood serum samples from 199 patients with primary bone neoplasms and 131 practically healthy volunteers was measured by ELISA. Borderline giantcell tumor of the bone with high osteoclastogenic and osteolytic activity is characterized by an increase in the level of all components of this system and highest ratio of sRANKL/OPG in the blood serum. Study indexes in patients with various benign neoplasms and tumor-like bone lesions were lower than in patients with giant-cell tumor...
August 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28852667/long-lasting-chondromyxoid-fibroma-of-the-zygoma-a-rare-case-report-and-review-of-literature
#16
Mohammad Javad Ashraf, Negar Azarpira, Navid Omidifar, Bijan Khademi
Chondromyxoid fibroma (CMF) is a benign tumor which usually occurs in skeletal long bones. Its presence in zygoma is extremely rare. The patient was a 47-year-old female, with chief complaint of painful swelling in the left side of zygoma since 1 month ago after a long-lasting painless swelling for about 15 years. Computed tomography scan showed an osteolytic lesion, in the body of left zygomatic bone with lobulated and well-demarcated margins. During surgery, the mass was completely excised and the histological feature of the tumor was in favor of CMF...
2017: Journal of Education and Health Promotion
https://www.readbyqxmd.com/read/28852349/an-osteological-study-on-the-prevalence-of-osteochondromas
#17
Gregory R Gaumer, Doug S Weinberg, Christopher D Collier, Patrick J Getty, Raymond W Liu
BACKGROUND: Osteochondromas are frequently reported to be the most common benign tumor of bone. However, there is not definitive data on their prevalence rate as they are often clinically silent, with previous studies estimating 1-3%. METHODS: We examined a large osteologic collection of 2954 skeletons to identify likely osteochondromas. One author examined all bones excluding the skull in each skeleton for atypical cortical projections. These candidates were then evaluated by an orthopedic resident and then a fellowship trained pediatric orthopedic surgeon for final inclusion using strict criteria...
2017: Iowa Orthopaedic Journal
https://www.readbyqxmd.com/read/28843590/expanding-the-borders-image-guided-procedures-for-the-treatment-of-musculoskeletal-tumors
#18
J Garnon, G Koch, J Caudrelier, G Tsoumakidou, R L Cazzato, A Gangi
Interventional radiology has revolutionized the local management of bone tumours, offering new minimal invasive alternatives to surgery and radiotherapy. Its role has continuously increased over the past years for the treatment of benign tumors and also of some malignant ones, especially in palliative situations. The development of protective techniques and new ablative technologies, such as cryoablation, contributes to expand the role of the interventional radiologist to new fields of applications in musculoskeletal oncology...
September 2017: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/28836852/do-the-expressions-of-epithelial-mesenchymal-transition-proteins-periostin-integrin-%C3%AE-4-and-fibronectin-correlate-with-clinico-pathological-features-and-prognosis-of-metastatic-castration-resistant-prostate-cancer
#19
Ece Konac, Ilker Kiliccioglu, Emrullah Sogutdelen, Asiye U Dikmen, Gulsah Albayrak, Cenk Y Bilen
Development of metastatic castration-resistant prostate cancer is a result of the lack of an apoptotic response by the tumor cells and loss of the ability to stick to adjacent cells through epithelial-mesenchymal transition. Although there are several strongly recommended biomarkers for determining prognosis of metastatic castration-resistant prostate cancer, only few of them may help decide the selection of the optimal treatment option. The mode of treatment sequencing in metastatic castration-resistant prostate cancer will be based on the individual characteristics of the patient...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28834661/intraoperative-crush-smear-cytology-of-vertebral-chondroblastoma-a-diagnostic-challenge
#20
Shilpa P Tathe, Sanjay N Parate, Kirti N Jaiswal, Archana A Randale
Chondroblastoma is a rare, cartilage producing primary neoplasm of the bone. Although generally benign, chondroblastoma is placed in the "intermediate, rarely metastasizing" category in the 2013 World Health Organization classification of bone tumors. It typically involves the epiphysis of long tubular bones and is exceptionally located in the vertebral column. To the best of our knowledge, less than 35 cases of vertebral chondroblastoma have been reported in the literature. We report a case of chondroblastoma involving D6 -D7 vertebrae in a 17-year-old male patient, diagnosed on intraoperative crush cytology and later confirmed on histopathology...
August 23, 2017: Diagnostic Cytopathology
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