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https://www.readbyqxmd.com/read/29786110/multi%C3%A2-layered-prevention-and-treatment-of-chronic-inflammation-organ-fibrosis-and-cancer-associated-with-canonical-wnt-%C3%AE-%C3%A2-catenin-signaling-activation-review
#1
Masaru Katoh
β‑catenin/CTNNB1 is an intracellular scaffold protein that interacts with adhesion molecules (E‑cadherin/CDH1, N‑cadherin/CDH2, VE‑cadherin/CDH5 and α‑catenins), transmembrane‑type mucins (MUC1/CD227 and MUC16/CA125), signaling regulators (APC, AXIN1, AXIN2 and NHERF1/EBP50) and epigenetic or transcriptional regulators (BCL9, BCL9L, CREBBP/CBP, EP300/p300, FOXM1, MED12, SMARCA4/BRG1 and TCF/LEF). Gain‑of‑function CTTNB1 mutations are detected in bladder cancer, colorectal cancer, gastric cancer, liver cancer, lung cancer, pancreatic cancer, prostate cancer and uterine cancer, whereas loss‑of‑function CTNNB1 mutations are also detected in human cancer...
May 17, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29780167/e-cadherin-in-contact-inhibition-and-cancer
#2
REVIEW
Alisha M Mendonsa, Tae-Young Na, Barry M Gumbiner
E-cadherin is a key component of the adherens junctions that are integral in cell adhesion and maintaining epithelial phenotype of cells. Homophilic E-cadherin binding between cells is important in mediating contact inhibition of proliferation when cells reach confluence. Loss of E-cadherin expression results in loss of contact inhibition and is associated with increased cell motility and advanced stages of cancer. In this review we discuss the role of E-cadherin and its downstream signaling in regulation of contact inhibition and the development and progression of cancer...
May 21, 2018: Oncogene
https://www.readbyqxmd.com/read/29767705/gut-selective-integrin-targeted-therapies-for-inflammatory-bowel-disease
#3
Christopher A Lamb, Sharon O'Byrne, Mary E Keir, Eugene C Butcher
Integrins are cell surface receptors with bi-directional signaling capabilities that can bind to adhesion molecules in order to mediate homing of leukocytes to peripheral tissues. Gut-selective leukocyte homing is facilitated by interactions between α4β7 and its ligand MAdCAM-1, while retention of lymphocytes in mucosal tissues is mediated by αEβ7 binding to its ligand E-cadherin. Therapies targeting gut-selective trafficking have shown efficacy in inflammatory bowel disease (IBD), confirming the importance of leukocyte trafficking in disease pathobiology...
May 15, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29755451/autoantibody-signaling-in-pemphigus-vulgaris-development-of-an-integrated-model
#4
REVIEW
Thomas Sajda, Animesh A Sinha
Pemphigus vulgaris (PV) is an autoimmune skin blistering disease effecting both cutaneous and mucosal epithelia. Blister formation in PV is known to result from the binding of autoantibodies (autoAbs) to keratinocyte antigens. The primary antigenic targets of pathogenic autoAbs are known to be desmoglein 3, and to a lesser extent, desmoglein 1, cadherin family proteins that partially comprise the desmosome, a protein structure responsible for maintaining cell adhesion, although additional autoAbs, whose role in blister formation is still unclear, are also known to be present in PV patients...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29746206/%C3%AE-t-catenin-a-developmentally-dispensable-disease-linked-member-of-the-%C3%AE-catenin-family
#5
Sergio E Chiarella, Erik E Rabin, Lorena A Ostilla, Annette S Flozak, Cara J Gottardi
α-Catenins are actin-filament binding proteins and critical subunits of the cadherin-catenin cell-cell adhesive complex. They are found in nominally-defined epithelial (E), neural (N), and testis (T) forms transcribed from three distinct genes. While most of α-catenin research has focused on the developmentally essential founding member, αE-catenin, this review discusses recent studies on αT-catenin (CTNNA3), a developmentally dispensable isoform that is emerging as relevant to cardiac, allergic and neurological diseases...
May 10, 2018: Tissue Barriers
https://www.readbyqxmd.com/read/29726955/involvement-of-partial-emt-in-cancer-progression
#6
Masao Saitoh
The epithelial-mesenchymal transition (EMT) provides an outstanding example of cellular plasticity during embryonic development and cancer progression. During EMT in embryonic development, epithelial cells lose all vestiges of their epithelial origin and acquire a fully mesenchymal phenotype, known as complete EMT, which is typically characterized by a so-called cadherin switch. Conversely, during EMT in cancer progression, cancer cells that originate from epithelial cells exhibit both mesenchymal and epithelial characteristics, i...
May 3, 2018: Journal of Biochemistry
https://www.readbyqxmd.com/read/29689229/tensile-forces-and-mechanotransduction-at-cell-cell-junctions
#7
REVIEW
Guillaume Charras, Alpha S Yap
Cell-cell junctions are specializations of the plasma membrane responsible for physically integrating cells into tissues. We are now beginning to appreciate the diverse impacts that mechanical forces exert upon the integrity and function of these junctions. Currently, this is best understood for cadherin-based adherens junctions in epithelia and endothelia, where cell-cell adhesion couples the contractile cytoskeletons of cells together to generate tissue-scale tension. Junctional tension participates in morphogenesis and tissue homeostasis...
April 23, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29643851/atomic-force-microscopy-provides-new-mechanistic-insights-into-the-pathogenesis-of-pemphigus
#8
REVIEW
Franziska Vielmuth, Volker Spindler, Jens Waschke
Autoantibodies binding to the extracellular domains of desmoglein (Dsg) 3 and 1 are critical in the pathogenesis of pemphigus by mechanisms leading to impaired function of desmosomes and blister formation in the epidermis and mucous membranes. Desmosomes are highly organized protein complexes which provide strong intercellular adhesion. Desmosomal cadherins such as Dsgs, proteins of the cadherin superfamily which interact via their extracellular domains in Ca2+ -dependent manner, are the transmembrane adhesion molecules clustered within desmosomes...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29576316/glycosylation-in-cancer-selected-roles-in-tumour-progression-immune-modulation-and-metastasis
#9
Joana G Rodrigues, Meritxell Balmaña, Joana A Macedo, Juliana Poças, Ângela Fernandes, Julio Cesar M de-Freitas-Junior, Salomé S Pinho, Joana Gomes, Ana Magalhães, Catarina Gomes, Stefan Mereiter, Celso A Reis
Tumour metastasis is the main cause of cancer related deaths. Metastasis is an intricate multi-step process that requires the acquisition of several cancer cell features, including the modulation of tumour cell migration, adhesion, invasion, and immune evasion. Changes in the cellular glycosylation are associated with malignant transformation of cancer cells, tumour progression and ultimately, metastasis formation. Glycans have major impact on cellular signalling and on the regulation of tumour cell-cell adhesion and cell-matrix interaction...
March 20, 2018: Cellular Immunology
https://www.readbyqxmd.com/read/29562686/profiling-prostate-cancer-therapeutic-resistance
#10
REVIEW
Cameron A Wade, Natasha Kyprianou
The major challenge in the treatment of patients with advanced lethal prostate cancer is therapeutic resistance to androgen-deprivation therapy (ADT) and chemotherapy. Overriding this resistance requires understanding of the driving mechanisms of the tumor microenvironment, not just the androgen receptor (AR)-signaling cascade, that facilitate therapeutic resistance in order to identify new drug targets. The tumor microenvironment enables key signaling pathways promoting cancer cell survival and invasion via resistance to anoikis...
March 19, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29549847/solid-pancreatic-pseudopapillary-tumor-managed-laparoscopically-a-case-report-and-review-of-the-literature
#11
D Cuccurullo, G Carbone, M G Iovino, I De Rosa, M Fabozzi, F Corcione
BACKGROUND: Solid pancreatic pseudopapillary tumors are a rare neoplasms, about 1-3% of all pancreatic neoplasms. This cancer mainly affects women between the third and fourth decade of life. They are not well known; the molecular origins represent a low degree of malignancy, in which the complete resection is curative. We report our experience with a case report of SPT in a young man. PRESENTATION OF CASE: Thirty-six years old male patient with a mass about 10 cm in the pancreatic tail and splenic ilum...
2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29546880/cell-motility-in-cancer-invasion-and-metastasis-insights-from-simple-model-organisms
#12
REVIEW
Christina H Stuelten, Carole A Parent, Denise J Montell
Metastasis remains the greatest challenge in the clinical management of cancer. Cell motility is a fundamental and ancient cellular behaviour that contributes to metastasis and is conserved in simple organisms. In this Review, we evaluate insights relevant to human cancer that are derived from the study of cell motility in non-mammalian model organisms. Dictyostelium discoideum, Caenorhabditis elegans, Drosophila melanogaster and Danio rerio permit direct observation of cells moving in complex native environments and lend themselves to large-scale genetic and pharmacological screening...
May 2018: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/29543670/genetic-basis-of-arrhythmogenic-cardiomyopathy
#13
Jennifer Karmouch, Alexandros Protonotarios, Petros Syrris
PURPOSE OF REVIEW: To date 16 genes have been associated with arrhythmogenic cardiomyopathy (ACM). Mutations in these genes can lead to a broad spectrum of phenotypic expression ranging from disease affecting predominantly the right or left ventricle, to biventricular subtypes. Understanding the genetic causes of ACM is important in diagnosis and management of the disorder. This review summarizes recent advances in molecular genetics and discusses the application of next-generation sequencing technology in genetic testing in ACM...
May 2018: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/29530992/a-cumulative-analysis-of-current-evidence-for-association-between-expression-of-epithelial-mesenchymal-transition-markers-and-clinicopathological-outcomes-in-patients-after-radical-prostatectomy
#14
GuangLiang Jiang, QingFeng Hu, Hui Wang, WeiHong Ding, Ning Zhang, YiShuo Wu, QiDong Zhou, ChuanYu Sun, GuoWei Xia, Qiang Ding, Rong Na, Ke Xu
BACKGROUND: Epithelial-mesenchymal transition (EMT) was reported to have an important effect on malignant metastasis; however, it remained largely unknown if EMT marker expression of neoplastic tissue had predictive value for prognosis of prostate cancer. METHODS: We searched for published studies which measured EMT marker expression and analyzed its association with clinical outcomes of patients after Radical Prostatectomy (RP). We reviewed and pooled-analyzed the association of EMT marker expression and biochemical recurrence-free survival (BFS), as well as the difference in strong or weak expression of EMT markers in tumors of high Gleason score (≥8)...
January 2018: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/29509243/targeting-histone-deacetylases-in-endometrial-cancer-a-paradigm-shifting-therapeutic-strategy
#15
N Garmpis, C Damaskos, A Garmpi, E Spartalis, E Kalampokas, T Kalampokas, G-A Margonis, D Schizas, N Andreatos, A Angelou, A Lavaris, A Athanasiou, K G Apostolou, M Spartalis, Z Damaskou, A Daskalopoulou, E Diamantis, K Tsivelekas, A Alavanos, S Valsami, M M Moschos, A Sampani, A Nonni, E A Antoniou, D Mantas, G Tsourouflis, K Markatos, K Kontzoglou, D Perrea, N Nikiteas, A Kostakis, D Dimitroulis
OBJECTIVE: Endometrial cancer is increasingly prevalent in western societies and affects mainly postmenopausal women; notably incidence rates have been rising by 1.9% per year on average since 2005. Although the early-stage endometrial cancer can be effectively managed with surgery, more advanced stages of the disease require multimodality treatment with varying results. In recent years, endometrial cancer has been extensively studied at the molecular level in an attempt to develop effective therapies...
February 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29476604/cut-loose-and-run-the-complex-role-of-adam-proteases-during-neural-crest-cell-development
#16
REVIEW
Dominique Alfandari, Lisa A Taneyhill
ADAM metalloproteases have been shown to play critical roles during development. In this review, we will describe functional evidence that implicates ADAM proteins during the genesis, migration and differentiation of neural crest cells. We will restrict our analysis to the transmembrane ADAMs as other reviews have addressed the role of extracellular metalloproteases (Christian et al. [2013] Critical Reviews in Biochemistry and Molecular Biology 48:544-560). This review will describe advances that have been obtained mainly through the use of two vertebrate model systems, the frog, and avian embryos...
February 24, 2018: Genesis: the Journal of Genetics and Development
https://www.readbyqxmd.com/read/29473514/the-role-of-ve-cadherin-in-blood-brain-barrier-integrity-under-central-nervous-system-pathological-conditions
#17
Wenlu Li, Zhigang Chen, Ian Chin, Zhong Chen, Haibin Dai
The blood-brain barrier (BBB) is a layer between the blood circulation and neural tissue. It plays a pivotal role in maintaining the vulnerable extracellular microenvironment in the neuronal parenchyma. Neuroinflammatory events can result in BBB dysregulation by disturbing adherens junctions (AJs) and tight junctions (TJs). VE-cadherin, as one of the most important components of the vascular system, is specifically responsible for the assembly of AJs and BBB architecture. Here, we present a review, which highlights recently available insights into the relationship between the neuroinflammation and BBB dysregulation...
February 22, 2018: Current Neuropharmacology
https://www.readbyqxmd.com/read/29468433/merging-perspectives-genotype-directed-molecular-therapy-for-hereditary-diffuse-gastric-cancer-hdgc-and-e-cadherin-egfr-crosstalk
#18
Dandan Li, Winifred Lo, Udo Rudloff
Hereditary diffuse gastric cancer is a cancer predisposition syndrome associated with germline mutations of the E-cadherin gene (CDH1; NM_004360). Male CDH1 germline mutation carriers have by the age of 80 years an estimated 70% cumulative incidence of gastric cancer, females of 56% for gastric and of 42% for lobular breast cancer. Metastatic HDGC has a poor prognosis which is worse than for sporadic gastric cancer. To date, there have been no treatment options described tailored to this molecular subtype of gastric cancer...
February 22, 2018: Clinical and Translational Medicine
https://www.readbyqxmd.com/read/29460532/lichen-planus-molecular-pathway-and-clinical-implications-in-oral-disorders
#19
M Boccellino, D Di Stasio, A Romano, M Petruzzi, A Lucchese, R Serpico, L Frati, M Di Domenico
Stem cells play a role in many mucosal disorders characterised by abnormal proliferation and differentiation of keratinocytes, such as oral lichen planus (OLP). In OLP there were changes in stem cell markers as component of integrin complexes α6 and β1 integrin increased along with increase of melanoma-associated chondroitin sulphate proteoglycan (MCSP) and decreased of notch1 (N1) and keratin 15 (K15). Stem cell marker expression may be altered by pathological signalling in these lesions. Cadherins are transmembrane receptors that provide cell-cell contact and communication function through calcium-dependent homophilic and heterophilic interactions...
January 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29460521/hpv-acting-on-e-cadherin-p53-and-p16-literature-review
#20
L Ottria, V Candotto, F Cura, L Baggi, C Arcuri, M Nardone, R M Gaudio, R Gatto, F Spadari, F Carinci
In addition to tobacco and alcohol consumption, the two main risk factors for oral squamous cell carcinoma (OSCC), recent studies have revealed infections with human papilloma virus (HPV) as an additional risk factor for OSCC development. In the field of head and neck malignancies, the prevalence of HPV infections in oropharyngeal cancer (OC) ranges in different studies up to 84%. While HPV infection is discussed as an independent risk factor in this region, its distinguished role in carcinogenesis of tumours localized to the oral cavity remains uncertain...
January 2018: Journal of Biological Regulators and Homeostatic Agents
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