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Embryo quality ectopic pregnancy

Bingqian Zhang, Linlin Cui, Rong Tang, Lingling Ding, Lei Yan, Zi-Jiang Chen
OBJECTIVE: To compare the risk of ectopic pregnancy (EP) after embryo transfer on day 3(D3-ET) and day 5(D5-ET). DESIGN: Meta-analysis. PATIENTS: Women with pregnancy resulting from in vitro undergoing in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI). RESULT(S): Twenty-two studies were identified through research conducted using the PubMed, Embase, and Cochrane databases and
2017: PloS One
Jing Liu, Xiao Zhang, Yue Yang, Junliang Zhao, Dayong Hao, Jianrui Zhang, Yanli Liu, Wenbin Wu, Xingling Wang
This study aimed to evaluate the impact of a short insemination procedure on embryo development, assess the reliability of a fertilization check prior to the appearance of pronuclei and elucidate the role of rescue intracytoplasmic sperm injection (R-ICSI). Patients who had ≥9 eggs, were aged <38 years and had normal semen samples were included. The sibling eggs of each patient were divided into two groups; one half for conventional in vitro fertilization (IVF; insemination time, 20 h) and the other half for short insemination (insemination time, 5 h)...
December 2016: Experimental and Therapeutic Medicine
Julie Brown, Salim Daya, Phill Matson
BACKGROUND: Embryo transfer (ET) was traditionally performed two days after oocyte retrieval; however, developments in culture media have allowed embryos to be maintained in culture for longer periods. Delaying transfer from Day two to Day three would allow for further development of the embryo and might have a positive effect on pregnancy outcomes. OBJECTIVES: To determine if there are any differences in live birth and pregnancy rates when embryo transfer is performed on day three after oocyte retrieval, compared with day two, in infertile couples undergoing treatment with in vitro fertilisation (IVF), including intracytoplasmic sperm injection (ICSI)...
December 14, 2016: Cochrane Database of Systematic Reviews
Laurentiu Craciunas, Nikolaos Tsampras, Arri Coomarasamy, Nick Raine-Fenning
BACKGROUND: Subfertility affects 15% of couples and represents the inability to conceive naturally following 12 months of regular unprotected sexual intercourse. Assisted reproduction refers to procedures involving the in vitro handling of both human gametes and represents a key option for many subfertile couples. Most women undergoing assisted reproduction treatment will reach the stage of embryo transfer (ET) but the proportion of embryos that successfully implant following ET has remained small since the mid-1990s...
May 20, 2016: Cochrane Database of Systematic Reviews
Julie Brown, Karen Buckingham, William Buckett, Ahmed M Abou-Setta
BACKGROUND: Many women undergoing an assisted reproductive technology (ART) cycle will not achieve a live birth. Failure at the embryo transfer stage may be due to lack of good-quality embryo/s, lack of uterine receptivity, or the transfer technique itself. Numerous methods, including the use of ultrasound guidance for proper catheter placement in the endometrial cavity, have been suggested as more effective techniques of embryo transfer. This review evaluates the efficacy of ultrasound-guided embryo transfer (UGET) compared with 'clinical touch' (CTET), which is the traditional method of embryo transfer and relies on the clinician's tactile senses to judge when the transfer catheter is in the correct position...
2016: Cochrane Database of Systematic Reviews
Mohammed Khairy, Rima K Dhillon, Justin Chu, Madhurima Rajkhowa, Arri Coomarasamy
Sub-endometrial junctional zone peristalsis is increased by ovarian stimulation and traumatic embryo transfer, and is linked with decreased implantation and pregnancy rates in assisted reproduction treatments. Various agents have been used to inhibit uterine hyper-peristalsis at the time of embryo transfer with conflicting results. This systematic review aimed to identify if uterine relaxants administered in the peri-implantation period during assisted reproduction treatments could improve pregnancy outcomes through literature search with no language restrictions...
April 2016: Reproductive Biomedicine Online
Fei Gong, Xihong Li, Shunji Zhang, Hainan Ma, Sufen Cai, Juan Li, G E Lin, Guangxiu Lu
There are currently various protocols for in vitro fertilization (IVF). For patients with polycystic ovarian syndrome (PCOS), an optimized protocol for the downregulation of pituitary follicle stimulating hormone and luteinizing hormone via gonadotropin-releasing hormone agonist (GnRHa) remains a challenge. In the present study, the primary endpoint of an ultra-long and a conventional long GnRHa protocol for intracytoplasmic sperm injection/IVF treatments of patients with PCOS was retrospectively compared. In the modified ultra-long protocol group, endometrial thickness, morphology, and blood flow were significantly improved, as compared with in the conventional long protocol group...
November 2015: Experimental and Therapeutic Medicine
Z Li, E A Sullivan, M Chapman, C Farquhar, Y A Wang
STUDY QUESTION: What type of transferred embryo is associated with a lower rate of ectopic pregnancy? SUMMARY ANSWER: The lowest risk of ectopic pregnancy was associated with the transfer of blastocyst, frozen and single embryo compared with cleavage stage, fresh and multiple embryos. WHAT IS KNOWN ALREADY: Ectopic pregnancy is a recognized complication following assisted reproductive technology (ART) treatment. It has been estimated that the rate of ectopic pregnancy is doubled in pregnancies following ART treatment compared with spontaneous pregnancies...
September 2015: Human Reproduction
Ilana Ramer, Tomi T Kanninen, Giovanni Sisti, Steven S Witkin, Steven D Spandorfer
OBJECTIVE: Components of the insulin-like growth factor (IGF) system enhance in vitro embryo quality and implantation rates in both animal models and human in vitro fertilization (IVF). We evaluated whether differences in serum levels of these components in women prior to initiation of an IVF cycle would be predictive of subsequent outcome. STUDY DESIGN: In this retrospective study sera from women obtained at day 2 of their IVF cycle (at baseline before stimulation) were assayed for IGF-I, IGF-II, and IGF binding protein (BP)-1 by enzyme-linked immunosorbent assay...
September 2015: American Journal of Obstetrics and Gynecology
Ronit Machtinger, Charles L Bormann, Elizabeth S Ginsburg, Catherine Racowsky
PURPOSE: Morphological evaluation is currently considered the single most important predictive measure for assessing embryo quality. The aim of this study was to investigate whether cycles with at least one non-cleaved embryo (i.e., a 1-cell embryo on day 3) have different outcomes compared with cycles in which all embryos had cleaved by day 3. METHODS: All autologous IVF/ICSI cycles with a fresh day 3 transfer and without using a gestational carrier performed at our center between 1/1/2010 and 12/31/2011 were analyzed retrospectively...
May 2015: Journal of Assisted Reproduction and Genetics
A Richardson, I Gallos, S Dobson, B K Campbell, A Coomarasamy, N Raine-Fenning
OBJECTIVES: To determine the accuracy of ultrasound in the diagnosis of a tubal ectopic pregnancy in the absence of an obvious extrauterine embryo. METHODS: This was a systematic review conducted in accordance with the PRISMA statement and registered with PROSPERO. We searched MEDLINE, EMBASE and The Cochrane Library for relevant citations from database inception to July 2014. Studies were selected in a two-stage process and their data extracted by two reviewers...
January 2016: Ultrasound in Obstetrics & Gynecology
Peiyu Wang, Junzhao Zhao, Congcong Jin, Rong Yu, Jia Lin, Ruru Zhu, Yonggen Wu
OBJECTIVE: To compare the laboratory and clinical results between unstimulated in vitro maturation (IVM) and IVM converted from in vitro fertilization (IVF) in polycystic ovarian syndrome (PCOS) and non-PCOS patients. METHODS: We divided 591 IVM cycles in the First Affiliated Hospital of Wenzhou Medical Univesity from Jan. 2008 to Dec. 2013 into 4 groups: group A1B1, PCOS patients underwent unstimulated IVM protocol, 240 cycles; group A1B2, PCOS patients underwent IVM converted from conventional stimulated IVF protocol, 153 cycles; group A2B1, non-PCOS patients underwent unstimutlated IVM protocol, 103 cycles; group A2B2, non-PCOS patient underwent IVM converted from conventional stimulated IVF protocol, 95 cycles...
December 2014: Zhonghua Fu Chan Ke za Zhi
Bo Li, Yefei Ma, Jianlei Huang, Xifeng Xiao, Li Li, Chuang Liu, Yongqian Shi, Dong Wang, Xiaohong Wang
Sperm morphology is the best predictor of fertilization potential, and the critical predictive information for supporting assisted reproductive methods selection. Given its important predictive value and the declining reality of semen quality in recent years, the threshold of normal sperm morphology rate (NSMR) is being constantly corrected and controversial, from the 4th edition (14%) to the 5th version (4%). We retrospectively analyzed 4756 cases of infertility patients treated with conventional-IVF(c-IVF) or ICSI, which were divided into three groups according to NSMR: ≥14%, 4%-14% and <4%...
2014: PloS One
Rosa B Gutarra-Vilchez, Gerard Urrútia, Demián Glujovsky, Andrea Coscia, Xavier Bonfill Cosp
BACKGROUND: Since 1978, when Patrick Steptoe and Robert Edwards achieved the birth of the first test tube baby, assisted reproductive techniques have been refined and improved. However, the rate of successful pregnancies brought to term has barely increased. Therefore closer evaluation of the interventions is needed along with working towards improving uterus receptivity. Vasodilators have been proposed to increase endometrial receptivity, thicken the endometrium and favour uterine relaxation, all of which could improve uterine receptivity and enhance the chances for successful assisted pregnancies...
2014: Cochrane Database of Systematic Reviews
Sadik Sahin, Alev Ozay, Elif Ergin, Lale Turkgeldi, Esra Kürüm, Hakan Ozornek
PURPOSE: The aim of this study was to compare the incidence of ectopic pregnancy in GnRH agonist triggered IVF cycles with intensive luteal support versus hCG triggered IVF cycles. METHODS: This study was conducted as a retrospective cohort analysis of women who underwent IVF treatment employing GnRH agonist or recombinant hCG (rhCG) triggers during 2-year period. The medical charts of women who achieved pregnancies were reviewed and their demographic characteristics, infertility reasons and IVF data were recorded...
January 2015: Archives of Gynecology and Obstetrics
Joyce Chai, Tracy W Y Yeung, Vivian C Y Lee, Raymond H W Li, Estella Y L Lau, William S B Yeung, P C Ho, Ernest H Y Ng
OBJECTIVE: To compare the live birth rate, multiple pregnancy rate, and obstetric outcomes of elective single and double embryo transfers. DESIGN: Case series with internal comparisons. SETTING: University affiliated hospital, Hong Kong. PARTICIPANTS: Between October 2009 and December 2011, 206 women underwent their first in-vitro fertilisation cycle. Elective single embryo transfer was offered to women who were aged 35 years or below, and had endometrial thickness of 8 mm or more and at least two embryos of good quality...
April 2014: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
Christina E Boots, Robert L Gustofson, Eve C Feinberg
OBJECTIVE: To evaluate the effects of methotrexate (MTX) on the future fertility of women undergoing IVF by comparing ovarian reserve and ovarian responsiveness in the IVF cycle before and after an ectopic pregnancy (EP) treated with MTX. DESIGN: Retrospective cohort study. SETTING: Private reproductive endocrinology and infertility practice. PATIENT(S): Sixty-six women undergoing IVF before and after receiving MTX for an EP...
December 2013: Fertility and Sterility
Charlotte H E Weimar, Nick S Macklon, Emiel D Post Uiterweer, Jan J Brosens, Birgit Gellersen
BACKGROUND Mechanisms underlying early reproductive loss in the human are beginning to be elucidated. The migratory and invasive capacity of human endometrial stromal cells (ESCs) is increasingly recognized to contribute to the intense tissue remodelling associated with embryo implantation, trophoblast invasion and endometrial regeneration. In this review, we examine the signals and mechanisms that control ESC migration and invasion and assess how deregulation of these cell functions contributes to common reproductive disorders...
September 2013: Human Reproduction Update
Tom Bourne, Cecilia Bottomley
In 2011, the first systematic review of the evidence behind the diagnostic criteria for miscarriage was published. It states, "findings were limited by the small number and poor quality of the studies," and concluded that further studies were, "urgently required before setting future standards for the accurate diagnosis of early embryonic demise." This implies that data used to define criteria to diagnose miscarriage are unreliable. The 2011 Irish Health Service executive review into miscarriage misdiagnosis highlighted this issue...
November 2012: Fertility and Sterility
Guixue Feng, Bo Zhang, Hong Zhou, Jinhui Shu, Xianyou Gan, Fangrong Wu, Xihe Deng
Selective single-blastocyst transfer (SBT) in fresh cycles has been effective in reducing multiple pregnancies. However, we do not know whether this successful strategy of fresh transfer cycles is suitable for cryopreserved cycles. The present study was undertaken to evaluate the feasibility and value of SBT in vitrified-warmed cycles. Clinical pregnancy rate (CPR) was similar with vitrified and fresh SBT (46.61% versus 52.15% respectively). Of the pregnant patients, monozygotic twin, miscarriage and ectopic pregnancy rates were similar with vitrified and fresh SBT...
November 2012: Reproductive Biomedicine Online
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