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Frozen embryo transfer

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https://www.readbyqxmd.com/read/28101111/a-randomized-trial-to-evaluate-the-effect-of-local-endometrial-injury-on-the-clinical-pregnancy-rate-of-frozen-embryo-transfer-cycles-in-patients-with-repeated-implantation-failure
#1
Ensieh Shahrokh-Tehraninejad, Minoo Dashti, Batool Hossein-Rashidi, Elham Azimi-Nekoo, Fedyeh Haghollahi, Vahid Kalantari
Objective: Repeated implantation failure (RIF) is a condition in which the embryos implantation decreases in the endometrium. So, our aim was to evaluate the effect of local endometrial injury on embryo transfer results. Materials and methods: In this simple randomized clinical trial (RCT), a total of 120 patients were selected. The participants were less than 40 years old, and they are in their minimum two cycles of vitro fertilization (IVF). Patients were divided randomly into two groups of LEI (Local endometrial injury) and a control group (n = 60 in each group)...
September 2016: Journal of Family & Reproductive Health
https://www.readbyqxmd.com/read/28089573/what-is-a-difficult-transfer-analysis-of-7-714-embryo-transfers-the-impact-of-maneuvers-during-embryo-transfers-on-pregnancy-rate-and-a-proposal-of-objective-assessment
#2
Alejandro Kava-Braverman, Francisca Martínez, Ignacio Rodríguez, Manuel Álvarez, Pedro N Barri, Buenaventura Coroleu
OBJECTIVE: To establish the relationship between the degree of difficulty of ET and pregnancy rate (PR), with a view to proposing an algorithm for the objective assessment of ET. DESIGN: Retrospective, observational study. SETTING: In vitro fertilization unit. PATIENT(S): Women undergoing assisted reproductive technology (ART) with ET after IVF/intracytoplasmic sperm injection, in whom fresh embryo transfer or frozen-thawed embryo transfer was performed...
January 12, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28069172/morphologic-grading-of-euploid-blastocysts-influences-implantation-and-ongoing-pregnancy-rates
#3
Mohamad Irani, David Reichman, Alex Robles, Alexis Melnick, Owen Davis, Nikica Zaninovic, Kangpu Xu, Zev Rosenwaks
OBJECTIVE: To determine whether blastocyst grading can predict pregnancy outcomes in the frozen-thawed embryo transfer (FET) of euploid blastocysts. DESIGN: Retrospective cohort study. SETTING: Academic medical center. PATIENT(S): Women who underwent FET of euploid embryo(s) between January 2013 and December 2015, with blastocysts were divided into four groups based on their morphologic grading before cryopreservation: excellent (≥3AA), good (3-6AB, 3-6BA, 1-2AA), average (3-6BB, 3-6AC, 3-6CA, 1-2AB, 1-2BA), and poor (1-6BC, 1-6CB, 1-6CC, 1-2BB)...
January 6, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28069012/systematic-review-of-worldwide-trends-in-assisted-reproductive-technology-2004-2013
#4
REVIEW
Vitaly A Kushnir, David H Barad, David F Albertini, Sarah K Darmon, Norbert Gleicher
BACKGROUND: Assisted Reproductive Technology (ART) has undergone considerable changes over the last decade, with consequences on ART outcomes in different regions of the world being unknown. METHODS: We conducted a systematic review of published national and regional ART registry data to assess how changes in clinical practice between 2004 and 2013 have impacted outcomes in Australia and New Zealand, Canada, Continental Europe, the United Kingdom (U.K.), Japan, Latin America, and the United States (U...
January 10, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28066833/the-role-of-g-csf-in-recurrent-implantation-failure-a-randomized-double-blind-placebo-control-trial
#5
Fatemeh Davari-Tanha, Ensieh Shahrokh Tehraninejad, Mohadese Ghazi, Zahra Shahraki
BACKGROUND: Recurrent implantation failure (RIF) is the absence of implantation after three consecutive In Vitro Fertilization (IVF) cycles with transferring at least four good quality embryos in a minimum of three fresh or frozen cycles in a woman under 40 years. The definition and management of RIF is under constant scrutiny. OBJECTIVE: To investigate the effects of Granulocyte colony stimulating factor (G-CSF) on RIF, pregnancy rate, abortion rate and implantation rates...
December 2016: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/28062550/what-is-the-optimal-means-of-preparing-the-endometrium-in-frozen-thawed-embryo-transfer-cycles-a-systematic-review-and-meta-analysis
#6
Eva R Groenewoud, Astrid E P Cantineau, Boudewijn J Kollen, Nick S Macklon, Ben J Cohlen
No abstract text is available yet for this article.
January 5, 2017: Human Reproduction Update
https://www.readbyqxmd.com/read/28058611/clinical-predictors-of-failing-one-dose-of-methotrexate-for-ectopic-pregnancy-after-in-vitro-fertilization
#7
Paula C Brady, Stacey A Missmer, Leslie V Farland, Elizabeth S Ginsburg
PURPOSE: The aim of this study is to investigate the clinical predictors of failure of a single dose of methotrexate (MTX) for management of ectopic pregnancy after in vitro fertilization (IVF). METHODS: A retrospective cohort study was performed of women who conceived ectopic pregnancies following fresh or frozen IVF cycles at an academic infertility clinic between 2007 and 2014, and received intramuscular MTX (50 mg/m(2)). Successful single-dose MTX treatment was defined as a serum beta-human chorionic gonadotropin (hCG) decline ≥15% between days 4 and 7 post-treatment...
January 5, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28050963/live-births-after-polar-body-biopsy-and-frozen-thawed-cleavage-stage-embryo-transfer-case-report
#8
Fernando Guimarães, Matheus Roque, Marcello Valle, Alessandra Kostolias, Rodrigo A de Azevedo, Ciro D Martinhago, Marcos Sampaio, Selmo Geber
Pre-implantation genetic diagnosis (PGD) or screening (PGS) technology, has emerged and developed in the past few years, benefiting couples as it allows the selection and transfer of healthy embryos during IVF treatments. These techniques can be performed in oocytes (polar-body biopsy) or embryos (blastomere or trophectoderm biopsy). In this case report, we describe the first two live births to be published in Brazil after a polar-body (PB) biopsy. In case 1, a 42-year-old was submitted to PB biopsy with PGS due to advanced maternal age and poor ovarian reserve...
December 1, 2016: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/28010150/repeated-doses-of-gnrh-antagonist-at-midcycle-in-artificial-frozen-embryo-transfer-cycles-may-not-affect-pregnancy-outcomes
#9
Katherine L Palmerola, Jennifer Y Hsu, Lisa C Grossman, Mark V Sauer, Roger A Lobo
No significant differences in outcomes have been found between protocols of endometrial preparation for frozen embryo transfer (FET), though gonadotropin releasing hormone (GnRH) antagonists may have detrimental effects on the endometrium. We conducted a retrospective cohort noninferiority study at a single academic center of women receiving multiple doses of mid-cycle GnRH antagonist (GAnt) to those receiving GnRH agonist (GAg) to determine if there are detrimental effects of GnRH antagonists. 1047 FET cycles were identified, detailed data was available in 840 cycles: 610 GAg and 230 GAnt cycles...
December 23, 2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28003868/outcome-of-one-hundred-consecutive-icsi-attempts-using-patient-operated-home-sonography-for-monitoring-follicular-growth
#10
J Gerris, F Vandekerckhove, P De Sutter
OBJECTIVE: cohort study describing clinical and laboratory outcomes in ICSI patients using self-operated endovaginal tele-monitoring (SOET). SETTING: University department of reproductive medicine. PATIENTS: 78 patients undergoing 100 consecutive ICSI attempts. INTERVENTIONS: patients' recorded vaginal sonograms and sent recordings using the cloud based Sonaura device to the care provider who procured responses, avoiding hospital visits...
September 2016: Facts, Views & Vision in ObGyn
https://www.readbyqxmd.com/read/27999118/effect-of-pretreatment-with-oral-contraceptives-and-progestins-on-ivf-outcomes-in-women-with-polycystic-ovary-syndrome
#11
Daimin Wei, Yuhua Shi, Jing Li, Ze Wang, Lin Zhang, Yun Sun, Hong Zhou, Yuping Xu, Chunxiang Wu, Ling Liu, Qiongfang Wu, Lili Zhuang, Yanzhi Du, Weiping Li, Heping Zhang, Richard S Legro, Zi-Jiang Chen
STUDY QUESTION: Do oral contraceptives (OCs) and progestins impact live birth rate of IVF when used for cycle scheduling in women with polycystic ovary syndrome (PCOS)? SUMMARY ANSWER: OCs used for scheduling IVF cycle were associated with lowered rates of pregnancy and live birth after fresh embryo transfer, whereas progestins used for this purpose yield higher rates of pregnancy and live birth than OCs. WHAT IS KNOWN ALREADY: Due to oligo-menorrhea in PCOS, OCs and progestin are extensively used to schedule the start of an IVF cycle in women with PCOS...
December 19, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27986819/there-is-no-evidence-that-the-time-from-egg-retrieval-to-embryo-transfer-affects-live-birth-rates-in-a-freeze-all-strategy
#12
K Lattes, M A Checa, R Vassena, M Brassesco, V Vernaeve
STUDY QUESTION: Does the time from ovum pick-up (OPU) to frozen embryo transfer (FET) affect reproductive outcomes in a freeze-all strategy? SUMMARY ANSWER: Our study did not detect statistically significant differences between first and subsequent cycles, clinically relevant differences are not ruled out and further and larger studies are required. WHAT IS KNOWN ALREADY: Following controlled ovarian hyperstimulation (COH) delaying FET until the endometrium has returned to an optimal pre-stimulation state may have a significant emotional impact on patients, which adds to the stress and anxiety accompanying a standard IVF cycle...
December 16, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27986817/the-slow-growing-embryo-and-premature-progesterone-elevation-compounding-factors-for-embryo-endometrial-asynchrony
#13
Mae Wu Healy, Meghan Yamasaki, George Patounakis, Kevin S Richter, Kate Devine, Alan H DeCherney, Micah J Hill
STUDY QUESTION: Is there an association of progesterone (P4) on the day of trigger with live birth in autologous ART transfer cycles on day 5 versus day 6? SUMMARY ANSWER: P4 had a greater negative effect on live birth in day 6 fresh transfers compared to day 5 fresh transfers. WHAT IS KNOWN ALREADY: Premature P4 elevation is associated with lower live birth rates in fresh autologous ART cycles, likely due to worsened endometrial-embryo asynchrony...
December 16, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27921085/effects-of-autologous-platelet-rich-plasma-on-implantation-and-pregnancy-in-repeated-implantation-failure-a-pilot-study
#14
Leila Nazari, Saghar Salehpour, Sedighe Hoseini, Shahrzad Zadehmodarres, Ladan Ajori
BACKGROUND: Repeated implantation failure (RIF) is a major challenge in reproductive medicine and despite several methods that have been described for management, there is little consensus on the most effective one. OBJECTIVE: This study was conducted to evaluate the effectiveness of platelet-rich plasma in improvement of pregnancy rate in RIF patients. MATERIALS AND METHODS: Twenty women with a history of RIF who were candidates for frozen-thawed embryo transfer were recruited in this study...
October 2016: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/27915038/intrauterine-administration-of-hcg-activated-autologous-human-peripheral-blood-mononuclear-cells-pbmc-promotes-live-birth-rates-in-frozen-thawed-embryo-transfer-cycles-of-patients-with-repeated-implantation-failure
#15
Saijiao Li, Jing Wang, Yan Cheng, Danni Zhou, Tailang Yin, Wangming Xu, Nan Yu, Jing Yang
Recurrent implantation failure refers to unsuccessful implantation after repeated transfers of morphologically good quality embryos into a normal uterus. Recently, accumulating evidence has suggested that local immune cells at the implantation site have actively contributed to embryo implantation. Our aim was to study the effects of intrauterine administration of hCG-activated autologous human PBMC on clinical pregnancy, implantation rates and live birth rate of patients who received frozen/thawed embryo transfer...
November 27, 2016: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/27893658/freeze-all-embryo-transfer-awareness-and-acceptance-of-ivf-et-patients-in-china
#16
Yan-Xiu Guo, Yan-Jing Yin, Li Tian
The aim of the study was to determine the level of awareness and acceptance of in vitro fertilization pre-embryo transfer (IVF-ET) patients for freeze-all embryo transfer, improve relevant technical specifications, and optimize treatment results based on medical experience.Questionnaires were completed by women who received in vitro fertilization embryo transfer. A total of 377 valid samples were included into this study. Through focus group discussions and tablet assisted intercept interviews, we analyzed the basic situation, the awareness for frozen-all embryo transfer, and the need for frozen-all embryo transfer information for infertile patients...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27889867/the-impact-of-younger-age-on-treatment-discontinuation-in-insured-ivf-patients
#17
Laura E Dodge, Denny Sakkas, Michele R Hacker, Rachael Feuerstein, Alice D Domar
PURPOSE: This retrospective cohort study aimed to determine whether age influences treatment discontinuation among insured patients undergoing in vitro fertilization (IVF). We hypothesized that the youngest patients would be the least likely to discontinue treatment. METHODS: All women age 18-42 who underwent their first fresh, non-donor IVF cycle from 2002 to 2013 were followed until a live birth was achieved, until they discontinued treatment at our center (not presenting for treatment for a one-year period), or until they completed six fresh or frozen embryo transfer cycles, whichever occurred first...
November 26, 2016: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/27889789/effect-of-natural-cycle-endometrial-preparation-for-frozen-thawed-embryo-transfer-in-patients-with-advanced-endometriosis
#18
Haiyan Guo, Yun Wang, Qiuju Chen, Weiran Chai, Qifeng Lv, Yanping Kuang
BACKGROUND The aim of this study was to investigate the effect of natural cycle (NC) endometrial preparation for frozen-thawed embryo transfer (FET) in women with advanced endometriosis. MATERIAL AND METHODS This retrospective study included 179 patients with stage III-IV endometriosis who underwent 233 FET cycles at a tertiary care academic reproductive medical center between March 2011 and August 2013 (group A). The control group included 258 patients with tubal factor infertility who underwent 300 FET cycles (group B)...
November 27, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27882628/the-influence-of-testicular-microlithiasis-on-the-outcomes-of-in-vitro-fertilisation-in-a-chinese-han-population
#19
C Xu, F-F Zhang, H-L Yang, G Ma, B Zhang, K-J Li, T-J Zhang, J-L Liu, X-J Xuan
To investigate the influence of testicular microlithiasis (TM) on the outcomes of in vitro fertilisation (IVF), we retrospectively reviewed the ultrasonography results of the TM patients who underwent IVF treatment in our hospital. They were classified as classic-TM (CTM) or limited-TM (LTM) comparing with patients without TM (Non-TM). Semen parameters, rates of fertilisation, normal fertilisation, good embryos and clinical pregnancy were analysed. The Non-TM group showed higher percentage of morphologically normal spermatozoa than the CTM or LTM group (4...
November 23, 2016: Andrologia
https://www.readbyqxmd.com/read/27874292/granulocyte-colony-stimulating-factor-treatment-of-resistant-thin-endometrium-in-women-with-frozen-thawed-blastocyst-transfer
#20
Michał Kunicki, Krzysztof Łukaszuk, Joanna Liss, Patrycja Skowrońska, Joanna Szczyptańska
: The aim of the study was to assess the granulocyte-colony stimulating factor (G-CSF) effect on unresponsive thin (<7 mm) endometrium in women undergoing frozen-thawed embryo transfer at the blastocyst stage. A total of 62 women with thin unresponsive endometrium were included in the study, of which, 29 received a G-CSF infusion and 33 who opted out of the study served as controls. Patients in both groups had similar endometrial thickness at the time of the initial evaluation: 6.50 mm (5...
November 22, 2016: Systems Biology in Reproductive Medicine
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