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Frozen embryo transfer

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https://www.readbyqxmd.com/read/29155965/is-frozen-embryo-transfer-better-for-mothers-and-babies-can-cumulative-meta-analysis-provide-a-definitive-answer
#1
Abha Maheshwari, Shilpi Pandey, Edwin Amalraj Raja, Ashalatha Shetty, Mark Hamilton, Siladitya Bhattacharya
BACKGROUND: Initial observational studies and a systematic review published 5 years ago have suggested that obstetric and perinatal outcomes are better in offspring conceived following frozen rather than fresh embryo transfers, with reduced risks of preterm birth, small for gestational age, low birth weight and pre-eclampsia. More recent primary studies are beginning to challenge some of these findings. We therefore conducted an updated systematic review and cumulative meta-analysis to examine if these results have remained consistent over time...
November 13, 2017: Human Reproduction Update
https://www.readbyqxmd.com/read/29152085/the-effect-of-human-chorionic-gonadotrophin-contained-in-human-menopausal-gonadotropin-on-the-clinical-outcomes-during-progestin-primed-ovarian-stimulation
#2
Xiuxian Zhu, Jing Ye, Yonglun Fu, Ai Ai, Renfei Cai, Yun Wang, Qingging Hong, Tian Hui, Qifeng Lyu, Qiuju Chen, Yanping Kuang
Progestin-primed ovarian stimulation (PPOS) protocol has recently been demonstrated to be an novel regimen for preventing premature LH surges during controlled ovarian hyperstimulation (COH) in combination with frozen-thawed embryo transfer (FET). Our prospective controlled study was to explore the effect of human chorionic gonadotropin (hCG) contained in human menopausal gonadotropin (hMG) on the clinical outcomes in normalovulatory women undergoing COH with PPOS. A total of 180 patients were allocated into three groups according to the gonadotropin (Gn) used: group A (human menopausal gonadotropin, hMG-A), group B (hMG-B) or group C (follicle stimulating hormone, FSH)...
October 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/29147846/hcg-administration-after-endogenous-lh-rise-negatively-influences-pregnancy-rate-in-modified-natural-cycle-for-frozen-thawed-euploid-blastocyst-transfer-a-pilot-study
#3
Katarzyna Litwicka, Cecilia Mencacci, Cristiana Arrivi, Maria Teresa Varricchio, Alina Caragia, Maria Giulia Minasi, Ermanno Greco
PURPOSE: The aim of the present study was to evaluate whether in a modified natural cycle (modified-NC) for a frozen-thawed single euploid blastocyst transfer, a critical LH value, above which human chorionic gonadotropin (hCG) administration should be avoided, may be defined. METHODS: One hundred and sixty-seven patients underwent modified natural cycle in order to transfer a single frozen-thawed euploid blastocyst. All embryos were obtained by intracytoplasmic sperm injection and were biopsied at the blastocyst stage and analyzed by means of array comparative genomic hybridization (aCGH)...
November 17, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29142450/autologous-intrauterine-platelet-rich-plasma-instillation-for-suboptimal-endometrium-in-frozen-embryo-transfer-cycles-a-pilot-study
#4
Sunita R Tandulwadkar, Manasi V Naralkar, Akash D Surana, M Selvakarthick, Avinash H Kharat
Introduction: This pilot study was to evaluate the effectiveness of intrauterine infusion of autologous platelet-rich plasma (PRP) in infertile women undergoing frozen embryo transfer cycles with suboptimal endometrium. Material and Methods: Intrauterine instillation of autologous PRP was done in 68 women between 22 and 40 years, over 8 months, with suboptimal endometrial growth, and patients with repeated cycle cancellations, in addition to Estradiol valerate. Frozen embryo transfer was performed when the endometrium reached an optimal pattern in terms of thickness, appearance, and vascularity...
July 2017: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/29136154/the-number-of-oocytes-retrieved-during-ivf-a-balance-between-efficacy-and-safety
#5
Åsa Magnusson, Karin Källen, Ann Thurin-Kjellberg, Christina Bergh
STUDY QUESTION: What is the relationship between the number of oocytes collected in fresh IVF treatments and the likelihood of cumulative delivery rate (fresh and frozen) per oocyte aspiration, severe ovarian hyperstimulation syndrome (OHSS) and thromboembolic events? SUMMARY ANSWER: Cumulative delivery rate per aspiration increases up to 20 oocytes retrieved and then evens out while the incidence of severe OHSS increases more rapidly from around 18 oocytes and thromboembolic events, although rare, occurs in particular if 15 or more oocytes are retrieved...
November 10, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29132037/flunixin-meglumine-improves-pregnancy-rate-in-embryo-recipient-beef-cows-with-an-excitable-temperament
#6
R K Kasimanickam, J B Hall, C T Estill, J P Kastelic, C Joseph, R L Abdel Aziz, D Nak
Objectives were to determine effects of: 1) handling temperament and administration of flunixin meglumine, an inhibitor of prostaglandin F2a (PGF2a) synthesis, given at the time of embryo transfer, on pregnancy rates in beef cattle embryo transfer recipients; 2) handling temperament and flunixin meglumine on peripheral concentrations of progesterone, cortisol, substance-P, prostaglandin F metabolites (PGFM, (13,14-dihydro-15-keto-PGF2a) and isoprostane 8-epi PGF2a; and 3) flunixin meglumine treatment on proportion of non-pregnant recipient cows returning to estrus within an expected interval...
November 10, 2017: Theriogenology
https://www.readbyqxmd.com/read/29125272/the-relationship-between-the-hormone-levels-before-transplantation-and-outcomes-of-hormone-replacement-therapy-frozen-embryo-transfer
#7
Yao-Fang Liu, Fang Wang, Gui-Ying Huang, Xi-Guang Mao
OBJECTIVE: To analyze the relationship between outcomes of hormone replacement therapy-frozen embryo transfer (HRT-FET) and serum estradiol and progesterone levels on the day of endometrial transformation and before transplantation. METHODS: Clinical datas of patients who underwent 426 cycles of FET were retrospectively analyzed and were divided into groups according to estradiol and progesterone levels. Differences in embryo implantation rate and clinical pregnancy rate were compared, and relationship between estradiol levels and outcome of transplantation was analyzed...
November 10, 2017: Minerva Endocrinologica
https://www.readbyqxmd.com/read/29117383/assisted-reproductive-technology-in-europe-2013-results-generated-from-european-registers-by-eshre
#8
C Calhaz-Jorge, C De Geyter, M S Kupka, J de Mouzon, K Erb, E Mocanu, T Motrenko, G Scaravelli, C Wyns, V Goossens
STUDY QUESTION: Are there any changes in the treatments involving ART and IUI initiated in Europe during 2013 compared with previous years? SUMMARY ANSWER: An increase in the overall number of ART cycles resulting from a higher number of countries reporting data was evident, the pregnancy rates (PRs) in 2013 remained stable compared with those reported in 2012, the number of transfers with multiple embryos (3+) was lower than ever before yet the multiple delivery rates (DRs) remained unchanged, and IUI activity and success rates were similar to those of last years...
October 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29116706/effect-of-sperm-dna-fragmentation-on-embryo-development-clinical-and-biological-aspects
#9
Cristian Alvarez Sedó, Melina Bilinski, Daniela Lorenzi, Heydy Uriondo, Felicitas Noblía, Valeria Longobucco, Estefanía Ventimiglia Lagar, Florencia Nodar
OBJECTIVE: The aim of this study was to investigate the effect of sperm DNA fragmentation on fertilization rate, embryo development (blastulation rate), and pregnancy outcomes for ICSI cycles performed in a cohort of couples using donor eggs and to assess the remaining embryos that were not transferred or frozen for apoptotic markers. METHODS: Eighty-two women (egg recipients) were included in the study (2016) were included in the study. The recipients' mean age was 41...
November 8, 2017: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/29110260/disparities-in-reproductive-outcomes-according-to-the-endometrial-preparation-protocol-in-frozen-embryo-transfer-the-risk-of-early-pregnancy-loss-in-frozen-embryo-transfer-cycles
#10
I Hatoum, L Bellon, N Swierkowski, M Ouazana, S Bouba, K Fathallah, B Paillusson, M Bailly, F Boitrelle, L Alter, M Bergère, J Selva, R Wainer
PURPOSE: The purpose of this study was to determine the effect of stimulated and artificial endometrial preparation protocols on reproductive outcomes in frozen embryo transfer (FET) cycles. METHODS: We performed a retrospective study of 1926 FET cycles over a 3.5-year period in the Fertility Unit at a University Hospital. Stimulated and artificial protocols were used for endometrial preparation. The embryos for FET were obtained from either in vitro fertilization or intracytoplasmic sperm injection cycles...
November 6, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29107981/prevalence-and-risk-factors-of-monochorionic-diamniotic-twinning-after-assisted-reproduction-a-six-year-experience-base-on-a-large-cohort-of-pregnancies
#11
Bing Song, Zhao-Lian Wei, Xiao-Feng Xu, Xue Wang, Xiao-Jin He, Huan Wu, Ping Zhou, Yun-Xia Cao
OBJECTIVE: To characterize the incidence and risk factors for monochorionic diamniotic(MC-DA) twinning after assisted reproductive technologies (ART). DESIGN: Retrospective population-based study. SETTING: The study was conducted in China; Department of Reproductive Medicine Center at The First Affiliated Hospital of Anhui Medical University. POPULATION: A cohort of 8860 clinical pregnancies after embryo transfer (ET) carried out in our center between 2011 and 2016 were retrospectively analyzed for the incidence of MC-DA twinning...
2017: PloS One
https://www.readbyqxmd.com/read/29102427/effect-of-repeated-cryopreservation-on-human-embryo-developmental-potential
#12
Xiaoying Zheng, Yuan Chen, Jie Yan, Yuqi Wu, Xinjie Zhuang, Shengli Lin, Jinliang Zhu, Ying Lian, Jie Qiao, Ping Liu
Repeated cryopreservation of surplus embryos from frozen-thawed cycles should occasionally be considered. The purpose of this retrospective cohort study was to evaluate the pregnancy and perinatal outcome of repeated cryopreservation by vitrification of human blastocysts derived from slowly frozen-thawed day 3 embryos. In total, 571 vitrified-warmed blastocyst transfer cycles were investigated. The vitrified-warmed blastocysts were derived from slowly frozen-thawed cleavage embryos (twice-cryopreserved group) or fresh embryos (control group) cultured to the blastocyst stage...
August 24, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29077229/does-cryopreservation-influence-perinatal-outcome-after-blastocyst-stage-vs-cleavage-stage-transfer-a-systematic-review-and-meta-analysis
#13
REVIEW
Carlo Alviggi, Alessandro Conforti, Ilma Floriana Carbone, Rosaria Borrelli, Giuseppe De Placido, Stefano Guerriero
OBJECTIVE: To compare the perinatal outcomes of singleton pregnancies between blastocyst and cleavage embryo transfer and to assess whether this differs between fresh and frozen embryo transfer cycles. METHODS: A systematic review of the literature was carried out using the SCOPUS, MEDLINE and ISI WEB OF SCIENCE databases with no time restriction. The search terms were "blastocyst", "cleavage-stage embryo", "perinatal outcome", "perinatal mortality", "preterm birth", "premature birth", "birth weight", "congenital abnormalities", "congenital defect", "deformity", and "birth defect"...
October 27, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29069987/in-vitro-fertilization-frozen-embryo-transfer-in-a-patient-with-cytochrome-p450-oxidoreductase-deficiency-a-case-report
#14
Tianran Song, Bin Wang, Huan Chen, Jingjing Zhu, Haixiang Sun
Cytochrome P450 enzymes are required for the synthesis of cholesterol and steroid hormones. Cytochrome P450 oxidoreductase (POR) donates electrons to microsomal cytochrome P450 enzymes. POR deficiency (PORD) is a rare autosomal recessive disease. In patients with PORD, steroid hormone synthesis is disrupted, which can cause infertility. The objective of this study was to report on a case of in vitro fertilization-frozen embryo transfer (IVF-FET) in a patient with PORD. The patient's hormone (i.e. 17α-hydroxyprogesterone) and electrolyte levels were within normal ranges ordinarily...
October 26, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29068264/two-consecutive-successful-live-birth-in-woman-with-17%C3%AE-hydroxylase-deficiency-by-frozen-thaw-embryo-transfer-under-hormone-replacement-endometrium-preparation
#15
Michio Kitajima, Kiyonori Miura, Tsuneo Inoue, Yuko Murakami, Yuriko Kitajima, Naoko Murakami, Ken Taniguchi, Ko-Ichiro Yoshiura, Hideaki Masuzaki
17α-Hydroxylase deficiency is rare autosomal recessive disorder that manifested by hypertension, hypokalemia, delayed sexual development, primary amenorrhea and infertility. The information regarding infertility care and conception in women with this disorder are extremely limited. We report a 24-year-old Japanese woman with primary amenorrhea who was diagnosed as partial 17α-hydroxylase deficiency caused by homozygous 3 bp deletion in exon 1 of 17α-hydroxylase gene. In vitro fertilization with controlled ovarian stimulation was carried out and all viable embryo were frozen...
October 25, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29047006/extended-culture-of-poor-quality-supernumerary-embryos-improves-art-outcomes
#16
Amira Sallem, Pietro Santulli, Virginie Barraud-Lange, Nathalie Le Foll, Lucile Ferreux, Chloé Maignien, Mathilde Bourdon, Charles Chapron, Dominique de Ziegler, Jean-Philippe Wolf, Khaled Pocate-Cheriet
PURPOSE: The aims of this study were to investigate the possible benefits of extending the culture of poor-quality day-2 embryos (PQE) versus good-quality embryos (GQE) and to identify factors associated with pregnancy and live birth when transferring frozen-thawed blastocysts originating from GQE and PQE. METHODS: This is a retrospective cohort follow-up study performed between November 2012 and February 2015 at the IVF Laboratory Unit of Cochin University Hospital (Paris, France) including 3108 day-2 supernumerary embryos resulting from 1237 IVF/ICSI cycles...
October 18, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29040606/pinopode-score-around-the-time-of-implantation-is-predictive-of-successful-implantation-following-frozen-embryo-transfer-in-hormone-replacement-cycles
#17
X Y Jin, L J Zhao, D H Luo, L Liu, Y D Dai, X X Hu, Y Y Wang, X Lin, F Hong, T C Li, S Y Zhang
STUDY QUESTION: Is pinopode measurement of any prognostic value? SUMMARY ANSWER: Pinopode expression was significantly associated with the occurrence of pregnancy after frozen embryo transfer. WHAT IS KNOWN ALREADY: Pinopodes are expressed in the endometrium during the implantation period. Pinopode measurement has been proposed as a marker of endometrial receptivity. STUDY DESIGN, SIZE, DURATION: A prospective cohort study was conducted at the Center of Reproductive Medicine, Sir Run Run Shaw Hospital, between 2014 and 2016, recruiting 172 women with infertility and undergoing frozen embryo transfer following IVF treatment...
October 13, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29040570/cumulative-live-birth-rates-following-miscarriage-in-an-initial-complete-cycle-of-ivf-a-retrospective-cohort-study-of-112-549-women
#18
Natalie J Cameron, Siladitya Bhattacharya, Sohinee Bhattacharya, David J McLernon
STUDY QUESTION: In women undergoing IVF/ICSI who miscarry in their first complete cycle, what is the chance of a live birth in subsequent complete cycles, and how does this compare with those whose first complete cycle ends with live birth or without a pregnancy? SUMMARY ANSWER: After two further complete cycles of IVF/ICSI, women who had miscarried or had a live birth in their first complete cycle had a higher chance of live birth (40.9 and 49.0%, respectively) than those who had no pregnancies (30...
November 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29040519/high-gonadotropin-dosage-does-not-affect-euploidy-and-pregnancy-rates-in-ivf-pgs-cycles-with-single-embryo-transfer
#19
Oleksii O Barash, Mary D Hinckley, Evan M Rosenbluth, Kristen A Ivani, Louis N Weckstein
STUDY QUESTION: Does high gonadotropin dosage affect euploidy and pregnancy rates in PGS cycles with single embryo transfer? SUMMARY ANSWER: High gonadotropin dosage does NOT affect euploidy and pregnancy rates in PGS cycles with single embryo transfer. WHAT IS KNOWN ALREADY: PGS has been proven to be the most effective and reliable method for embryo selection in IVF cycles. Euploidy and blastulation rates decrease significantly with advancing maternal age...
November 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29039173/-effects-of-embryo-cryopreservation-and-thawing-on-clinical-outcomes-of-transplantable-embryos-after-cleavage-stage-preimplantation-genetic-diagnosis-or-screening
#20
Biwei Shi, Long Cui, Xiaoqun Ye, Yinghui Ye
OBJECTIVE: To investigate the effects of embryo cryopreservation and thawing on clinical outcomes of transplantable embryos after preimplantation genetic diagnosis (PGD) or preimplantation genetic screening (PGS) in cleavage-stage. METHODS: The clinical data of 302 cases (including 118 cases using frozen/thawing embryos and 184 cases using fresh embryos) undergoing PGD/PGS in Women's Hospital, Zhejiang University School of Medicine during January 2011 and December 2016 were retrospectively analyzed...
May 25, 2017: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
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