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https://www.readbyqxmd.com/read/27913205/trp-channels-in-calcium-homeostasis-from-hormonal-control-to-structure-function-relationship-of-trpv5-and-trpv6
#1
REVIEW
Mark K C van Goor, Joost G J Hoenderop, Jenny van der Wijst
Maintaining plasma calcium levels within a narrow range is of vital importance for many physiological functions. Therefore, calcium transport processes in the intestine, bone and kidney are tightly regulated to fine-tune the rate of absorption, storage and excretion. The TRPV5 and TRPV6 calcium channels are viewed as the gatekeepers of epithelial calcium transport. Several calciotropic hormones control the channels at the level of transcription, membrane expression, and function. Recent technological advances have provided the first near-atomic resolution structural models of several TRPV channels, allowing insight into their architecture...
November 30, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27751461/re-mucin-1-increases-renal-trpv5-activity-in%C3%A2-vitro-and-urinary-level-associates-with-calcium-nephrolithiasis-in-patients
#2
Dean G Assimos
No abstract text is available yet for this article.
November 2016: Journal of Urology
https://www.readbyqxmd.com/read/27632366/evaluation-and-comparison-of-vitamin-d-responsive-gene-expression-in-ovine-canine-and-equine-kidney
#3
Sara Azarpeykan, Keren E Dittmer, Jonathan C Marshall, Kalyani C Perera, Erica K Gee, Els Acke, Keith G Thompson
The aim of this study was to determine the relative abundance and relationship of vitamin D responsive and calcium transporting transcripts (TRPV5, TRPV6, calD9k, calD28k, PMCA, NCX1, CYP27B1, CYP24A1, and VDR) in ovine, canine and, equine kidney using quantitative real-time PCR (RT-qPCR), and then perform a comparison between the three species. Renal tissue samples were harvested post-mortem from 10 horses, 10 sheep, and five dogs. Primers were designed for each gene. For each sample total RNA was extracted, cDNA synthesised, and RT-qPCR was performed...
2016: PloS One
https://www.readbyqxmd.com/read/27622885/fgf23-klotho-signaling-axis-in-the-kidney
#4
Reinhold G Erben, Olena Andrukhova
Fibroblast growth factor-23 (FGF23) is a bone-derived hormone protecting against the potentially deleterious effects of hyperphosphatemia by suppression of phosphate reabsorption and of active vitamin D hormone synthesis in the kidney. The kidney is one of the main target organs of FGF23 signaling. The purpose of this review is to highlight the recent advances in the area of FGF23-Klotho signaling in the kidney. During recent years, it has become clear that FGF23 acts independently on proximal and distal tubular epithelium...
September 10, 2016: Bone
https://www.readbyqxmd.com/read/27469036/is-the-renal-kallikrein-kinin-system-a-factor-that-modulates-calciuria
#5
Armando Luis Negri
Renal tubular calcium reabsorption is one of the principal factors that determine serum calcium concentration and calcium excretion. Calcium excretion is regulated by the distal convoluted tubule and connecting tubule, where the epithelial calcium channel TRPV5 can be found, which limits the rate of transcellular calcium transport. The dynamic presence of the TRPV5 channel on the surface of the tubular cell is mediated by an endosomal recycling process. Different intrarenal factors are involved in calcium channel fixation in the apical membrane, including the anti-ageing hormone klotho and tissue kallikrein (TK)...
July 25, 2016: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/27409607/regulation-of-intestinal-epithelial-calcium-transport-proteins-by-stanniocalcin-1-in-caco2-cells
#6
Jinmei Xiang, Rui Guo, Chunyun Wan, Liming Wu, Shijin Yang, Dingzong Guo
Stanniocalcin-1 (STC1) is a calcium and phosphate regulatory hormone. However, the exact molecular mechanisms underlying how STC1 affects Ca(2+) uptake remain unclear. Here, the expression levels of the calcium transport proteins involved in transcellular transport in Caco2 cells were examined following over-expression or inhibition of STC1. These proteins include the transient receptor potential vanilloid members (TRPV) 5 and 6, the plasma membrane calcium ATPase 1b (PMCA1b), the sodium/calcium exchanger (NCX1), and the vitamin D receptor (VDR)...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27296226/crystal-structure-of-the-epithelial-calcium-channel-trpv6
#7
Kei Saotome, Appu K Singh, Maria V Yelshanskaya, Alexander I Sobolevsky
Precise regulation of calcium homeostasis is essential for many physiological functions. The Ca(2+)-selective transient receptor potential (TRP) channels TRPV5 and TRPV6 play vital roles in calcium homeostasis as Ca(2+) uptake channels in epithelial tissues. Detailed structural bases for their assembly and Ca(2+) permeation remain obscure. Here we report the crystal structure of rat TRPV6 at 3.25 Å resolution. The overall architecture of TRPV6 reveals shared and unique features compared with other TRP channels...
June 23, 2016: Nature
https://www.readbyqxmd.com/read/27291418/a-molecular-determinant-of-phosphoinositide-affinity-in-mammalian-trpv-channels
#8
Phanindra Velisetty, Istvan Borbiro, Marina A Kasimova, Luyu Liu, Doreen Badheka, Vincenzo Carnevale, Tibor Rohacs
Phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] is an important cofactor for ion channels. Affinity for this lipid is a major determinant of channel inhibition by depletion of PI(4,5)P2 upon phospholipase C (PLC) activation. Little is known about what determines PI(4,5)P2 affinity in mammalian ion channels. Here we report that two members of the Transient Receptor Potential Vanilloid (TRPV) ion channel family, TRPV5 and TRPV6 lack a positively charged residue in the TM4-TM5 loop that was shown to interact with PI(4,5)P2 in TRPV1, which shows high affinity for this lipid...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27184746/evidence-for-the-functional-involvement-of-members-of-the-trp-channel-family-in-the-uptake-of-na-and-nh4-by-the-ruminal-epithelium
#9
Julia Rosendahl, Hannah S Braun, Katharina T Schrapers, Holger Martens, Friederike Stumpff
Large quantities of protein are degraded in the fermentative parts of the gut to ammonia, which is absorbed, detoxified to urea, and excreted, leading to formation of nitrogenous compounds such as N2O that are associated with global warming. In ruminants, channel-mediated uptake of NH4 (+) from the rumen predominates. The molecular identity of these channels remains to be clarified. Ruminal cells and epithelia from cows and sheep were investigated using patch clamp, Ussing chamber, microelectrode techniques, and qPCR...
August 2016: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/27102152/lifelong-challenge-of-calcium-homeostasis-in-male-mice-lacking-trpv5-leads-to-changes-in-bone-and-calcium-metabolism
#10
Bram C J van der Eerden, W Nadia H Koek, Paul Roschger, M Carola Zillikens, Jan H Waarsing, Annemiete van der Kemp, Marijke Schreuders-Koedam, Nadja Fratzl-Zelman, Pieter J M Leenen, Joost G J Hoenderop, Klaus Klaushofer, René J M Bindels, Johannes P T M van Leeuwen
Trpv5 plays an important role in calcium (Ca2+) homeostasis, among others by mediating renal calcium reabsorption. Accordingly, Trpv5 deficiency strongly stresses Ca2+ homeostasis in order to maintain stable serum Ca2+. We addressed the impact of lifelong challenge of calcium homeostasis on the bone phenotype of these mice.Aging significantly increased serum 1,25(OH)2D3 and PTH levels in both genotypes but they were more elevated in Trpv5-/- mice, whereas serum Ca2+ was not affected by age or genotype. Age-related changes in trabecular and cortical bone mass were accelerated in Trpv5-/- mice, including reduced trabecular and cortical bone thickness as well as reduced bone mineralization...
May 3, 2016: Oncotarget
https://www.readbyqxmd.com/read/27101128/calcium-extrusion-pump-pmca4-a-new-player-in-renal-calcium-handling
#11
Ellen P M van Loon, Robert Little, Sukhpal Prehar, René J M Bindels, Elizabeth J Cartwright, Joost G J Hoenderop
Calcium (Ca2+) is vital for multiple processes in the body, and maintenance of the electrolyte concentration is required for everyday physiological function. In the kidney, and more specifically, in the late distal convoluted tubule and connecting tubule, the fine-tuning of Ca2+ reabsorption from the pro-urine takes place. Here, Ca2+ enters the epithelial cell via the transient receptor potential vanilloid receptor type 5 (TRPV5) channel, diffuses to the basolateral side bound to calbindin-D28k and is extruded to the blood compartment via the Na+/Ca2+ exchanger 1 (NCX1) and the plasma membrane Ca2+ ATPase (PMCA)...
2016: PloS One
https://www.readbyqxmd.com/read/27036738/mucin-1-increases-renal-trpv5-activity-in-vitro-and-urinary-level-associates-with-calcium-nephrolithiasis-in-patients
#12
Mingzhu Nie, Manjot S Bal, Zhufeng Yang, Jie Liu, Carolina Rivera, Andrea Wenzel, Bodo B Beck, Khashayar Sakhaee, Denise K Marciano, Matthias T F Wolf
Hypercalciuria is a major risk factor for nephrolithiasis. We previously reported that Uromodulin (UMOD) protects against nephrolithiasis by upregulating the renal calcium channel TRPV5. This channel is crucial for calcium reabsorption in the distal convoluted tubule (DCT). Recently, mutations in the gene encoding Mucin-1 (MUC1) were found to cause autosomal dominant tubulointerstitial kidney disease, the same disease caused by UMOD mutations. Because of the similarities between UMOD and MUC1 regarding associated disease phenotype, protein structure, and function as a cellular barrier, we examined whether urinary MUC1 also enhances TRPV5 channel activity and protects against nephrolithiasis...
November 2016: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/26837804/molecular-modeling-of-the-structural-and-dynamical-changes-in-calcium-channel-trpv5-induced-by-the-african-specific-a563t-variation
#13
Lingyun Wang, Ross P Holmes, Ji-Bin Peng
Transient receptor potential cation channels, vanilloid subfamily, member 5 (TRPV5) plays a key role in active Ca(2+) reabsorption in the kidney. Variations in TRPV5 occur at high frequency in African populations and may contribute to their higher efficiency of Ca(2+) reabsorption. One of the African specific variations, A563T, exhibits increased Ca(2+) transport ability. However, it is unclear how this variation influences the channel pore. On the basis of the structure of TRPV1, a TRPV5 model was generated to simulate the structural and dynamical changes induced by the A563T variation...
March 1, 2016: Biochemistry
https://www.readbyqxmd.com/read/26747426/urinary-%C3%AE-galactosidase-stimulates-ca2-transport-by-stabilizing-trpv5-at-the-plasma-membrane
#14
Elizabeth H P Leunissen, Maxime G Blanchard, Fareeba Sheedfar, Marla Lavrijsen, Jenny van der Wijst, René J M Bindels, Joost G J Hoenderop
Transcellular Ca(2+)transport in the late distal convoluted tubule and connecting tubule (DCT2/CNT) of the kidney is a finely controlled process mediated by the transient receptor potential vanilloid type 5 (TRPV5) channel. A complex-type-N-glycan bound at the extracellular residue Asn358 of TRPV5 through post-translational glycosylation has been postulated to regulate the activity of TRPV5 channels. Using in vitro Ca(2+)transport assays, immunoblot analysis, immunohistochemistry, patch clamp electrophysiology and total internal reflection fluorescence microscopy, it is demonstrated that the glycosidase β-galactosidase (β-gal), an enzyme that hydrolyzes galactose, stimulates TRPV5 channel activity...
May 2016: Glycobiology
https://www.readbyqxmd.com/read/26677674/-effect-of-zhibai-dihuang-decoction-on-expressions-of-trpv1-and-trpv5-in-spermatogenic-cells-of-uu-infected-rats
#15
Qing-hu He, Xuan-zuo Guo, Jun-hua Guo, Ying-qiu Li, Chao-sheng Liu
OBJECTIVE: To observe the effect of Zhibai Dihuang Decoction (ZDD) on mRNA and protein expressions of transient receptor potential family vanilloid subtype 1 (TRPV1) and transient receptor potential family vanilloid subtype 5 (TRPV5) in Ureaplasma urealyticum (UU)-infected rat semens and spermatogenic cells, and to explore the pathomechanism of UU-infected infertility and the intervention of ZDD. METHODS: Totally 45 were randomly selected from 60 4-5 months old SD rats...
October 2015: Chinese Journal of Integrated Traditional and Western Medicine
https://www.readbyqxmd.com/read/26608788/pth-modulation-of-ncc-activity-regulates-trpv5-ca2-reabsorption
#16
Robert S Hoover, Viktor Tomilin, Lauren Hanson, Oleh Pochynyuk, Benjamin Ko
Since parathyroid hormone (PTH) is known to increase transient receptor potential vanilloid (TRPV)5 activity and decrease Na(+)-Cl(-) cotransporter (NCC) activity, we hypothesized that decreased NCC-mediated Na(+) reabsorption contributes to the enhanced TRPV5 Ca(2+) reabsorption seen with PTH. To test this, we used mDCT15 cells expressing functional TRPV5 and ruthenium red-sensitive (45)Ca(2+) uptake. PTH increased (45)Ca(2+) uptake to 8.8 ± 0.7 nmol·mg(-1)·min(-1) (n = 4, P < 0.01) and decreased NCC activity from 75...
January 15, 2016: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/26582761/the-role-of-calbindin-d28k-on-renal-calcium-and-magnesium-handling-during-treatment-with-loop-and-thiazide-diuretics
#17
Chien-Te Lee, Hwee-Yeong Ng, Yueh-Ting Lee, Li-Wen Lai, Yeong-Hau H Lien
Calbindin-D28k (CBD-28k) is a calcium binding protein located in the distal convoluted tubule (DCT) and plays an important role in active calcium transport in the kidney. Loop and thiazide diuretics affect renal Ca and Mg handling: both cause Mg wasting, but have opposite effects on Ca excretion as loop diuretics increase, but thiazides decrease, Ca excretion. To understand the role of CBD-28k in renal Ca and Mg handling in response to diuretics treatment, we investigated renal Ca and Mg excretion and gene expression of DCT Ca and Mg transport molecules in wild-type (WT) and CBD-28k knockout (KO) mice...
February 1, 2016: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/26582172/potassium-citrate-decreases-urine-calcium-excretion-in-patients-with-hypocitraturic-calcium-oxalate-nephrolithiasis
#18
Yan Song, Natalia Hernandez, Jonathan Shoag, David S Goldfarb, Brian H Eisner
Two previous studies (<10 patients each) have demonstrated that alkali therapy may reduce urine calcium excretion in patients with calcium oxalate nephrolithiasis. The hypothesized mechanisms are (1) a decrease in bone turnover due to systemic alkalinization by the medications; (2) binding of calcium by citrate in the gastrointestinal tract; (3) direct effects on TRPV5 activity in the distal tubule. We performed a retrospective review of patients on potassium citrate therapy to evaluate the effects of this medication on urinary calcium excretion...
April 2016: Urolithiasis
https://www.readbyqxmd.com/read/26347652/alterations-in-reversible-protein-histidine-phosphorylation-as-intracellular-signals-in-cardiovascular-disease
#19
REVIEW
Thomas Wieland, Paul V Attwood
Reversible phosphorylation of amino acid side chains in proteins is a frequently used mechanism in cellular signal transduction and alterations of such phosphorylation patterns are very common in cardiovascular diseases. They reflect changes in the activities of the protein kinases and phosphatases involving signaling pathways. Phosphorylation of serine, threonine, and tyrosine residues has been extensively investigated in vertebrates, whereas reversible histidine phosphorylation, a well-known regulatory signal in lower organisms, has been largely neglected as it has been generally assumed that histidine phosphorylation is of minor importance in vertebrates...
2015: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/26272126/common-and-rare-variants-associated-with-kidney-stones-and-biochemical-traits
#20
Asmundur Oddsson, Patrick Sulem, Hannes Helgason, Vidar O Edvardsson, Gudmar Thorleifsson, Gardar Sveinbjörnsson, Eik Haraldsdottir, Gudmundur I Eyjolfsson, Olof Sigurdardottir, Isleifur Olafsson, Gisli Masson, Hilma Holm, Daniel F Gudbjartsson, Unnur Thorsteinsdottir, Olafur S Indridason, Runolfur Palsson, Kari Stefansson
Kidney stone disease is a complex disorder with a strong genetic component. We conducted a genome-wide association study of 28.3 million sequence variants detected through whole-genome sequencing of 2,636 Icelanders that were imputed into 5,419 kidney stone cases, including 2,172 cases with a history of recurrent kidney stones, and 279,870 controls. We identify sequence variants associating with kidney stones at ALPL (rs1256328[T], odds ratio (OR)=1.21, P=5.8 × 10(-10)) and a suggestive association at CASR (rs7627468[A], OR=1...
2015: Nature Communications
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