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https://www.readbyqxmd.com/read/28425305/development-of-a-soluplus%C3%A2-budesonide-freeze-dried-powder-for-nasal-drug-delivery
#1
Michele Pozzoli, Daniela Traini, Paul M Young, Maria B Sukkar, Fabio Sonvico
OBJECTIVE: The aim of this work was to develop an amorphous solid dispersions/solutions (ASD) of a poorly soluble drug, Budesonide (BUD) with a novel polymer Soluplus(®) (BASF, Germany) using a freeze-drying technique, in order to improve dissolution and absorption through the nasal route. SIGNIFICANCE: The small volume of fluid present in the nasal cavity limits the absorption of a poorly soluble drug. Budesonide is a corticosteroid, practically insoluble, and normally administered as a suspension-based nasal spray...
April 20, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28415507/influences-of-doping-mesoporous-magnesium-silicate-on-water-absorption-drug-release-degradability-apatite-mineralization-and-primary-cells-responses-to-calcium-sulfate-based-bone-cements
#2
Zhengrong Gu, Sicheng Wang, Weizong Weng, Xiao Chen, Liehu Cao, Jie Wei, Jung-Woog Shin, Jiacan Su
In this study, composite cements containing mesoporous magnesium silicate (m-MS) and calcium sulfate (CS) were fabricated. The results revealed that the setting time of the m-MS/CS composite cements (m-MSC) slightly prolonged with the increase of m-MS content while the compressive strength suffered a little loss. The doping of m-MS improved the water absorption, drug release (vancomycin) and degradability of the m-MSC in Tris-HCl solution (pH=7.4). In addition, addition of m-MS facilitated the apatite-mineralization of m-MSC in simulated body fluid (SBF), indicating good bioactivity...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28412519/vitamin-d-signaling-in-intestinal-innate-immunity-and-homeostasis
#3
REVIEW
Vassil Dimitrov, John H White
The lumen of the gut hosts a plethora of microorganisms that participate in food assimilation, inactivation of harmful particles and in vitamin synthesis. On the other hand, enteric flora, a number of food antigens, and toxins are capable of triggering immune responses causing inflammation, which, when unresolved, may lead to chronic conditions such as inflammatory bowel disease (IBD). It is important, therefore, to contain the gut bacteria within the lumen, control microbial load and composition, as well as ensure adequate innate and adaptive immune responses to pathogenic threats...
April 12, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28410612/milk-protein-based-formulas-containing-different-oils-affect-fatty-acids-balance-in-term-infants-a-randomized-blinded-crossover-clinical-trial
#4
Carolina Oliveira de Souza, Maria Efigênia Q Leite, John Lasekan, Geraldine Baggs, Lorena Silva Pinho, Janice Izabel Druzian, Tereza Cristina M Ribeiro, Ângela P Mattos, José A Menezes-Filho, Hugo Costa-Ribeiro
BACKGROUND: Palm olein is used in infant formula fat blends in order to match the fatty acid profile of human milk. While the effects on fatty acid balance have been evaluated, the use of palm olein in combination with palm kernel oil and supplementation with docosahexaenoic acid (DHA) and arachidonic acid (ARA) has not been similarly assessed in infants. This study evaluated the effects of infant formulas containing different fat compositions on the balance of fat, fatty acids, and calcium...
April 14, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28400273/the-role-of-vitamin-d-in-the-endocrinology-controlling-calcium-homeostasis
#5
REVIEW
James C Fleet
Vitamin D and its' metabolites are a crucial part of the endocrine system that controls whole body calcium homeostasis. The goal of this hormonal control is to regulate serum calcium levels so that they are maintained within a very narrow range. To achieve this goal, regulatory events occur in coordination at multiple tissues, e.g. the intestine, kidney, bone, and parathyroid gland. Production of the vitamin D endocrine hormone, 1,25 dihydroxyvitamin D (1,25(OH)2 D) is regulated by habitual dietary calcium intake and physiologic states like growth, aging, and the menopause...
April 9, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28390071/preparation-and-bioavailability-of-calcium-chelating-peptide-complex-from-tilapia-skin-hydrolysates
#6
Jun Chen, Xujian Qiu, Gengxin Hao, Meng Zhang, Wuyin Weng
BACKGROUND: With the continuous improvement of material life, the fish by-product and the market demand for calcium supplements have been increasing in China. Therefore, the calcium-chelating peptide complex (CPC) from tilapia skins was prepared, and the effect of the CPC on the Ca-deficiency mice was investigated. RESULTS: The molecular weight distribution of CPC was mainly ranged from 2000 Da to 180 Da, and the contents of complete amino acids and free amino acids in the CPC were 85...
April 8, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28385243/recyclable-magnetic-carboxymethyl-chitosan-calcium-alginate-cellulase-bioconjugates-for-corn-stalk-hydrolysis
#7
Jianfang Jiang, Jiaqi Zhao, Chunyang He, Baodong Cui, Jun Xiong, Hao Jiang, Juan Ao, Guangyan Xiang
The use of cellulase hydrolysis of straw to produce fermentable sugars has many application prospects. However, cellulase is very expensive, which hampers its industrial applications. To improve cellulase's catalytic activity and reduce the enzyme cost, magnetite carboxymethyl chitosan/calcium alginate - cellulase bioconjugate (MCCCB) was synthesized via an improved hydrothermal method, molecular self-assembly technology, physical absorption, embedding and covalent bonding. Its loading capacity was 3.95mg/mL, and the catalytic activity increased to 267...
June 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28382112/the-role-of-vitamin-d-in-maintaining-bone-health-in-older-people
#8
REVIEW
Thomas R Hill, Terry J Aspray
This review summarises aspects of vitamin D metabolism, the consequences of vitamin D deficiency, and the impact of vitamin D supplementation on musculoskeletal health in older age. With age, changes in vitamin D exposure, cutaneous vitamin D synthesis and behavioural factors (including physical activity, diet and sun exposure) are compounded by changes in calcium and vitamin D pathophysiology with altered calcium absorption, decreased 25-OH vitamin D [25(OH)D] hydroxylation, lower renal fractional calcium reabsorption and a rise in parathyroid hormone...
April 2017: Therapeutic Advances in Musculoskeletal Disease
https://www.readbyqxmd.com/read/28375561/physicochemical-properties-and-cytotoxicity-of-an-experimental-resin-based-pulp-capping-material-containing-the-quaternary-ammonium-salt-and-portland-cement
#9
Y W Yang, F Yu, H C Zhang, Y Dong, Y N Qiu, Y Jiao, X D Xing, M Tian, L Huang, J H Chen
AIM: To evaluate in vitro the physicochemical properties, cytotoxicity and calcium phosphate nucleation of an experimental light-curable pulp-capping material composed of a resin with antibacterial monomer (MAE-DB) and Portland cement (PC). METHODOLOGY: The experimental material was prepared by mixing PC with a resin containing MAE-DB at a 2:1 ratio. Cured pure resin containing MAE-DB served as control resin. ProRoot MTA and Dycal served as commercial controls. The depth of cure, degree of monomer conversion, water absorption and solubility of dry samples, calcium release, alkalinizing activity, calcium phosphate nucleation and the cytotoxicity of materials were evaluated...
April 4, 2017: International Endodontic Journal
https://www.readbyqxmd.com/read/28366690/calcium-and-organic-matter-removal-by-carbonation-process-with-waste-incineration-flue-gas-towards-improvement-of-leachate-biotreatment-performance
#10
Cheng Zhang, Xuedong Zhu, Liang Wu, Qingtao Li, Jianyong Liu, Guangren Qian
Municipal solid wastes incineration (MSWI) flue gas was employed as the carbon source for in-situ calcium removal from MSWI leachate. Calcium removal efficiency was 95-97% with pH of 10.0-11.0 over 100min of flue gas aeration, with both bound Ca and free Ca being removed effectively. The fluorescence intensity of tryptophan, protein-like and humic acid-like compounds increased after carbonation process. The decrease of bound Ca with the increase of precipitate indicated that calcium was mainly converted to calcium carbonate precipitate...
March 11, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28364648/retardation-of-uranium-and-thorium-by-a-cementitious-backfill-developed-for-radioactive-waste-disposal
#11
M Felipe-Sotelo, J Hinchliff, L P Field, A E Milodowski, O Preedy, D Read
The solubility of uranium and thorium has been measured under the conditions anticipated in a cementitious, geological disposal facility for low and intermediate level radioactive waste. Similar solubilities were obtained for thorium in all media, comprising NaOH, Ca(OH)2 and water equilibrated with a cement designed as repository backfill (NRVB, Nirex Reference Vault Backfill). In contrast, the solubility of U(VI) was one order of magnitude higher in NaOH than in the remaining solutions. The presence of cellulose degradation products (CDP) results in a comparable solubility increase for both elements...
July 2017: Chemosphere
https://www.readbyqxmd.com/read/28353638/a-specific-peptide-with-calcium-binding-capacity-from-defatted-schizochytrium-sp-protein-hydrolysates-and-the-molecular-properties
#12
Xixi Cai, Qian Yang, Jiaping Lin, Nanyan Fu, Shaoyun Wang
Marine microorganisms have been proposed as a new kind of protein source. Efforts are needed in order to transform the protein-rich biological wastes left after lipid extraction into value-added bio-products. Thus, the utilization of protein recovered from defatted Schizochytrium sp. by-products presents an opportunity. A specific peptide Tyr-Leu (YL) with calcium-binding capacity was purified from defatted Schizochytrium sp. protein hydrolysates through gel filtration chromatography and RP-HPLC. The calcium-binding activity of YL reached 126...
March 29, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28349531/characterization-of-sea-cucumber-stichopus-japonicus-ovum-hydrolysates-calcium-chelation-solubility-and-absorption-into-intestinal-epithelial-cells
#13
Na Sun, Pengbo Cui, Songyi Lin, Cuiping Yu, Yue Tang, Ye Wei, Youling Xiong, Haitao Wu
BACKGROUND: Sea cucumber (stichopus japonicus) ovum hydrolysates (SCOHs) chelated with calcium were produced to investigate the characteristics of calcium binding and solubility, as well as study its effect on calcium absorption by human intestinal epithelial cells. RESULTS: It is demonstrated that the calcium-binding capacity of SCOHs depended greatly on the type of proteases. The maximum level of Ca binding (0.38 mmol/L) occurred when trypsin was used, with a peptide yield of 85...
March 27, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28346014/intestinal-absorption-and-renal-reabsorption-of-calcium-throughout-postnatal-development
#14
Megan R Beggs, R Todd Alexander
Calcium is vital for many physiological functions including bone mineralization. Postnatal deposition of calcium into bone is greatest in infancy and continues through childhood and adolescence until peek mineral density is reached in early adulthood. Thereafter, bone mineral density remains static until it eventually declines in later life. A positive calcium balance, i.e. more calcium absorbed than excreted, is crucial to bone deposition during growth and thus to peek bone mineral density. Dietary calcium is absorbed from the intestine into the blood...
April 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28322159/towards-predicting-the-cytochrome-p450-modulation-from-qsar-to-proteochemometric-modeling
#15
Watshara Shoombuatong, Philip Prathipati, Veda Prachayasittikul, Nalini Schaduangrat, Aijaz Ahmad Malik, Reny Pratiwi, Sompon Wanwimolruk, Jarl E S Wikberg, Matthew Paul Gleeson, Ola Spjuth, Chanin Nantasenamat
Drug metabolism determines the fate of a drug when it enters the human body and is a critical factor in defining their absorption, distribution, metabolism, excretion and toxicity (ADMET) characteristics. Among the various drug metabolizing enzymes, cytochrome P450s (CYP450) constitute an important protein family that aside from functioning in xenobiotic metabolism is also responsible for a diverse array of other roles encompassing steroid and cholesterol biosynthesis, fatty acid metabolism, calcium homeostasis, neuroendocrine functions and growth regulation...
March 20, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28320893/regional-differences-in-nutrient-induced-secretion-of-gut-serotonin
#16
Alyce M Martin, Amanda L Lumsden, Richard L Young, Claire F Jessup, Nick J Spencer, Damien J Keating
Enterochromaffin (EC) cells located in the gastrointestinal (GI) tract provide the vast majority of serotonin (5-HT) in the body and constitute half of all enteroendocrine cells. EC cells respond to an array of stimuli, including various ingested nutrients. Ensuing 5-HT release from these cells plays a diverse role in regulating gut motility as well as other important responses to nutrient ingestion such as glucose absorption and fluid balance. Recent data also highlight the role of peripheral 5-HT in various pathways related to metabolic control...
March 2017: Physiological Reports
https://www.readbyqxmd.com/read/28318400/new-frontiers-in-fibers-innovative-and-emerging-research-on-the-gut-microbiome-and-bone-health
#17
Taylor C Wallace, Massimo Marzorati, Lisa Spence, Connie M Weaver, Patricia S Williamson
The complex interactions between the diet, gut microbiome, and host characteristics that provide a functional benefit to the host are an area of great interest and current exploration in the nutrition and health science community. New technologies are available to assess mechanisms that may explain these functional benefits to the host. One emerging functional benefit from changes in the gut microbiome is increased calcium absorption, increased calcium retention, and improved indices of bone health. Prebiotic fibers enhance microbial fermentation in the gut, providing an ecological advantage to specific nonpathogenic bacteria that have the ability to modify an individual's metabolic potential...
March 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/28318299/lithocholic-acid-a-new-emergent-protector-of-intestinal-calcium-absorption-under-oxidant-conditions
#18
Ana M Marchionatti, Adriana Pérez, María A Rivoira, Valeria A Rodríguez, Nori G Tolosa de Talamoni
LCA and 1,25(OH)2D3 are vitamin D receptor ligands with different binding affinity. The secosteroid stimulates intestinal Ca(2+) absorption. Whether LCA alters this process remains unknown. The aim of our work was to determine the effect of LCA on intestinal Ca(2+) absorption in the absence or presence of NaDOC, bile acid that inhibits the cation transport. The data show that LCA by itself did not alter intestinal Ca(2+) absorption, but prevented the inhibitory effect of NaDOC. The concomitant administration of LCA avoided the reduction of intestinal alkaline phosphatase activity caused by NaDOC...
April 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28316920/measurement-of-ph-and-calcium-ions-release-from-different-calcium-hydroxide-pastes-at-different-intervals-of-time-atomic-spectrophotometric-analysis
#19
Pranab Misra, Rhythm Bains, Kapil Loomba, Abhinav Singh, V P Sharma, R C Murthy, Rakesh Kumar
AIM: To evaluate the effect of different vehicles on pH and release of calcium ions from calcium hydroxide (CH) paste from apical third of root canals. METHODS: 40 single rooted extracted human mandibular premolars were instrumented with RevoS files (MicroMega) up to ISO size 40. The teeth were divided into 4 groups on the basis of vehicle as follows: Group I - calcium hydroxide mixed with 2% chlorhexidine; Group II - calcium hydroxide mixed with propylene glycol; Group III - calcium hydroxide mixed with glycerine; and Control - calcium hydroxide mixed with double distilled water...
January 2017: Journal of Oral Biology and Craniofacial Research
https://www.readbyqxmd.com/read/28300882/bromoderma-in-an-infant
#20
Isadora da Rosa Hoefel, Fernanda Oliveira Camozzato, Laura Netto Hagemann, Deise Louise Bohn Rhoden, Ana Elisa Kiszewski
Bromoderma is a cutaneous eruption caused by the absorption of bromide. Clinical manifestations include acneiform and vegetative lesions. We report the case of an infant with bromoderma caused by the use of syrup for abdominal colic containing calcium bromide. The lesions regressed after discontinuation of the drug.
September 2016: Anais Brasileiros de Dermatologia
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