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https://www.readbyqxmd.com/read/29036655/mfib-a-repository-of-protein-complexes-with-mutual-folding-induced-by-binding
#1
Erzsébet Fichó, István Reményi, István Simon, Bálint Mészáros
Motivation: It is commonplace that intrinsically disordered proteins (IDPs) are involved in crucial interactions in the living cell. However, the study of protein complexes formed exclusively by IDPs is hindered by the lack of data and such analyses remain sporadic. Systematic studies benefited other types of protein-protein interactions paving a way from basic science to therapeutics; yet these efforts require reliable datasets that are currently lacking for synergistically folding complexes of IDPs...
August 3, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29036588/a-novel-data-structure-to-support-ultra-fast-taxonomic-classification-of-metagenomic-sequences-with-k-mer-signatures
#2
Xinan Liu, Ye Yu, Jinpeng Liu, Corrine F Elliott, Chen Qian, Jinze Liu
Motivation: Metagenomic read classification is a critical step in the identification and quantification of microbial species sampled by high-throughput sequencing. Although many algorithms have been developed to date, they suffer significant memory and/or computational costs. Due to the growing popularity of metagenomic data in both basic science and clinical applications, as well as the increasing volume of data being generated, efficient and accurate algorithms are in high demand. Results: We introduce MetaOthello, a probabilistic hashing classifier for metagenomic sequencing reads...
July 7, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29036569/opportunities-for-epidemiologists-in-implementation-science-a-primer
#3
Gila Neta, Ross C Brownson, David A Chambers
The field of epidemiology has been defined as the study of the spread and control of disease. However, epidemiology frequently focuses on studies of etiology and distribution of disease at the cost of understanding the best ways to control disease. Moreover, only a small fraction of scientific discoveries is translated into public health practice, and the process from discovery to translation is exceedingly slow. Given the importance of translational science, the future of epidemiologic training should include competency in implementation science, whose goal is to rapidly move evidence into practice...
September 27, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29035219/an-embedded-real-time-processing-platform-for-optogenetic-neuroprosthetic-applications
#4
Boyuan Yan, Sheila Nirenberg
Optogenetics offers a powerful new approach for controlling neural circuits. It has numerous applications in both basic and clinical science. These applications require stimulating devices with small processors that can perform real-time neural signal processing, deliver high intensity light with high spatial and temporal resolution, and do not consume a lot of power. In this paper, we demonstrate the implementation of neuronal models in a platform consisting of an embedded system module and a portable DLP projector...
October 16, 2017: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/29034096/evaluating-the-impact-of-brexit-on-the-pharmaceutical-industry
#5
REVIEW
Fawz Kazzazi, Cleo Pollard, Paul Tern, Alejandro Ayuso-Garcia, Jack Gillespie, Inesa Thomsen
INTRODUCTION: The UK Pharmaceutical Industry is arguably one of the most important industries to consider in the negotiations following the Brexit vote. Providing tens of thousands of jobs and billions in tax revenue and research investment, the importance of this industry cannot be understated. At stake is the global leadership in the sector, which produces some of the field's most influential basic science and translation work. However, interruptions and losses may occur at multiple levels, affecting patients, researchers, universities, companies and government...
2017: Journal of Pharmaceutical Policy and Practice
https://www.readbyqxmd.com/read/29033318/an-alkynyl-fucose-halts-hepatoma-cell-migration-and-invasion-by-inhibiting-gdp-fucose-synthesizing-enzyme-fx-tsta3
#6
Yasuhiko Kizuka, Miyako Nakano, Yoshiki Yamaguchi, Kazuki Nakajima, Ritsuko Oka, Keiko Sato, Chien-Tai Ren, Tsui-Ling Hsu, Chi-Huey Wong, Naoyuki Taniguchi
Fucosylation is a glycan modification critically involved in cancer and inflammation. Although potent fucosylation inhibitors are useful for basic and clinical research, only a few inhibitors have been developed. Here, we focus on a fucose analog with an alkyne group, 6-alkynyl-fucose (6-Alk-Fuc), which is used widely as a detection probe for fucosylated glycans, but is also suggested for use as a fucosylation inhibitor. Our glycan analysis using lectin and mass spectrometry demonstrated that 6-Alk-Fuc is a potent and general inhibitor of cellular fucosylation, with much higher potency than the existing inhibitor, 2-fluoro-fucose (2-F-Fuc)...
September 19, 2017: Cell Chemical Biology
https://www.readbyqxmd.com/read/29031826/the-top-100-cited-of-injury-international-journal-of-the-care-of-the-injured-a-bibliometric-analysis
#7
REVIEW
Peng Luo, Ding Xu, Jia Wu, Yi-Heng Chen, Roman Pfeifer, Hans-Christoph Pape
BACKGROUND: With nearly 50 years' of development, Injury has become one of the leading journals in its specialty. The aim of this article is to identify, analyze the characteristics of the 100 most cited articles published by the journal to date. METHOD: We searched the Thomson Reuters Web of Science Core Collection for citations of all articles published in Injury since its launch. For the Top 100 most frequently cited articles, title, author name, number of authors, publishing date, citation number, country of origin, institution, pages, number of reference, type of article, study topic, study design, funding source, and level of evidence of each clinical article were recorded and analyzed...
October 9, 2017: Injury
https://www.readbyqxmd.com/read/29029671/presidential-address-embracing-the-repulsive-the-case-for-disgust-as-a-functionally-central-emotional-state-in-the-theory-practice-and-dissemination-of-cognitive-behavior-therapy
#8
Dean McKay
Disgust is a primary emotion, but it is also understudied in general, and in psychopathology in particular. Disgust plays a potential role in the reluctance of many non-scientifically minded practitioners from adopting evidence-based methods of treatment. This article summarizes findings from psychopathology research and treatment, and highlights basic science that potentially accounts for the hesitancy for some therapists to adopt evidence-based methods. Several recommendations are provided for future research in disgust related to both psychopathology and dissemination research...
November 2017: Behavior Therapy
https://www.readbyqxmd.com/read/29028859/neurotoxins-evidence-for-prevention
#9
Shannon Humphrey
<p>Onabotulinum Toxin A is the gold standard treatment for temporary dynamic rhytid reduction. Clinicians have observed a long-term and preventive benefit for patients beyond muscle relaxation particularly in patients who receive repeated treatments over time. These changes include progressive reduction of rhytides, prevention of dynamic rhytides, and improvements in skin quality. In this brief paper, we review basic science, clinical, and anecdotal evidence that explores a long-term and potential preventive effect of Onabotulinum Toxin A injections...
June 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29028857/treating-the-young-aesthetic-patient-evidence-based-recommendations
#10
Lauren Meshkov Bonati, Sabrina Guillen Fabi
<p>BACKGROUND: There is growing demand for cosmetic treatments in the younger population, yet counseling and treating this age group can be difficult to justify.</p> <p>OBJECTIVE: Chronologic changes that cause noticeable signs of aging are discussed within each age group. Age-appropriate cosmetic preventions and interventions are therefore recommended.</p> <p>METHODS: A PubMed search was performed for high quality trials and evidence based reviews on the basic science of aging, as well as on cosmetic modalities and their histological, biochemical, and clinical effects...
June 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29028120/rethinking-the-way-we-do-research-the-benefits-of-community-engaged-citizen-science-approaches-and-nontraditional-collaborators
#11
REVIEW
Danielle M Dick
There is tremendous opportunity for basic scientists to enhance the impact of our research by engaging more deeply with nontraditional partners and expanding the way we think about interdisciplinary research teams. These efforts can include more deeply engaging our participants, and the broader public, in our research; working with individuals from other fields to take a more active role in the dissemination and translation of our research; and working with collaborators from the arts and communication sciences to make our research more engaging and understandable...
October 13, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29026466/influenza-research-in-the-eastern-mediterranean-region-a-review
#12
REVIEW
Wasiq Khan, Amira S El Rifay, Mamun Malik, Ghazi Kayali
Given the importance of influenza infections in the Eastern Mediterranean Region (EMR), we conducted a comprehensive literature review to analyze the status of influenza research in the region from 2012. Influenza research has gained more momentum recently with the emergence of H5N1 and new virus strains. Research covering epidemiological, veterinary, and basic science aspects is growing. More sequences were being generated per year, not only for diagnostic purposes but also for research. We included gray literature publications in our search and found several graduate student dissertations from Egypt, which were published on an online portal...
September 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/29024520/allergen-immunotherapy-exploring-areas-for-further-inquiry
#13
Tam Ramsey, Wanda Lai, Peter F Svider, Houmehr Hojjat, Jean Anderson Eloy, Adam J Folbe
BACKGROUND: Allergy-related illness impacts millions of individuals worldwide. Our objectives were to characterize current trends of clinical trials research relating to allergen immunotherapy and to describe the landscape of allergen immunotherapy in National Institutes of Health (NIH)-supported research inquiry. METHODS: On ClinicalTrials.gov, the following terms were searched: allergen immunotherapy OR allergy immunotherapy. Variables, including completion status, dates, design, study population, funder, location, and allergen were recorded...
October 12, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29022344/development-of-photoacoustic-probes-for-in-vivo-molecular-imaging
#14
Christopher J Reinhardt, Jefferson Chan
Photoacoustic (PA) imaging is an emerging, non-invasive imaging modality that encompasses attributes of both optical and ultrasound imaging. Because of the combination of optical excitation and acoustic detection, PA imaging enables high contrast and high resolution within deep tissue (centimeter depths). Recent advances in PA probe development have allowed for stimulus-responsive imaging in a variety of biological models with implications for basic, translational, and clinical sciences. This perspective highlights recent progress in the development of PA probes and their application to live-animal molecular imaging...
October 12, 2017: Biochemistry
https://www.readbyqxmd.com/read/29022264/experimental-evidences-supporting-the-benefits-of-exercise-training-in-heart-failure
#15
Marcelo H A Ichige, Marcelo G Pereira, Patrícia C Brum, Lisete C Michelini
Heart Failure (HF), a common end point for many cardiovascular diseases, is a syndrome with a very poor prognosis. Although clinical trials in HF have achieved important outcomes in reducing mortality, little is known about functional mechanisms conditioning health improvement in HF patients. In parallel with clinical studies, basic science has been providing important discoveries to understand the mechanisms underlying the pathophysiology of HF, as well as to identify potential targets for the treatment of this syndrome...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29022262/myocardial-infarction-and-exercise-training-evidence-from-basic-science
#16
Ivana C Moraes-Silva, Bruno Rodrigues, Hélio J Coelho-Junior, Daniele Jardim Feriani, Maria-Claudia Irigoyen
In 2016, cardiovascular disease remains the first cause of mortality worldwide [1]. Coronary artery disease, which is the most important precursor of myocardial infarction (MI), is the main component of total cardiovascular mortality, being responsible for approximately seven million of deaths [1]. In approximately 20% of infarcted patients, MI is recurrent in the first year after the event [2]. Moreover, among cardiovascular disease, coronary artery disease accounts for the most increased index of life years lost due to morbidity and/or mortality [1]...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29021553/development-of-a-cell-based-assay-for-measuring-base-excision-repair-responses
#17
Tyler Golato, Boris Brenerman, Daniel R McNeill, Jianfeng Li, Robert W Sobol, David M Wilson
Base excision repair (BER) is the predominant pathway for coping with most forms of hydrolytic, oxidative or alkylative DNA damage. Measuring BER capacity in living cells is valuable for both basic science applications and epidemiological studies, since deficiencies in this pathway have been associated with cancer susceptibility and other adverse health outcomes. At present, there is an ongoing effort to develop methods to effectively quantify the rate of BER as a whole. We present a variation of a previously described "Oligonucleotide Retrieval Assay" designed to measure DNA excision repair that is capable of quantifying the rate of repair of thymine glycol in a variety of human cells with a high degree of sensitivity...
October 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29019488/fluorescent-chemosensors-the-past-present-and-future
#18
Di Wu, Adam C Sedgwick, Thorfinnur Gunnlaugsson, Engin U Akkaya, Juyoung Yoon, Tony D James
Fluorescent chemosensors for ions and neutral analytes have been widely applied in many diverse fields such as biology, physiology, pharmacology, and environmental sciences. The field of fluorescent chemosensors has been in existence for about 150 years. In this time, a large range of fluorescent chemosensors have been established for the detection of biologically and/or environmentally important species. Despite the progress made in this field, several problems and challenges still exist. This tutorial review introduces the history and provides a general overview of the development in the research of fluorescent sensors, often referred to as chemosensors...
October 11, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/29017480/longitudinal-assessment-of-daily-activity-patterns-on-weight-change-after-involuntary-job-loss-the-adapt-study-protocol
#19
Patricia L Haynes, Graciela E Silva, George W Howe, Cynthia A Thomson, Emily A Butler, Stuart F Quan, Duane Sherrill, Molly Scanlon, Darlynn M Rojo-Wissar, Devan N Gengler, David A Glickenstein
BACKGROUND: The World Health Organization has identified obesity as one of the most visible and neglected public health problems worldwide. Meta-analytic studies suggest that insufficient sleep increases the risk of developing obesity and related serious medical conditions. Unfortunately, the nationwide average sleep duration has steadily declined over the last two decades with 25% of U.S. adults reporting insufficient sleep. Stress is also an important indirect factor in obesity, and chronic stress and laboratory-induced stress negatively impact sleep...
October 10, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29016679/perimenopause-and-emergence-of-an-alzheimer-s-bioenergetic-phenotype-in-brain-and-periphery
#20
Lisa Mosconi, Valentina Berti, Crystal Guyara-Quinn, Pauline McHugh, Gabriella Petrongolo, Ricardo S Osorio, Christopher Connaughty, Alberto Pupi, Shankar Vallabhajosula, Richard S Isaacson, Mony J de Leon, Russell H Swerdlow, Roberta Diaz Brinton
After advanced age, female sex is the major risk factor for Alzheimer's disease (AD). The biological mechanisms underlying the increased AD risk in women remain largely undetermined. Preclinical studies identified the perimenopause to menopause transition, a neuroendocrine transition state unique to the female, as a sex-specific risk factor for AD. In animals, estrogenic regulation of cerebral glucose metabolism (CMRglc) falters during perimenopause. This is evident in glucose hypometabolism and decline in mitochondrial efficiency which is sustained thereafter...
2017: PloS One
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