keyword
MENU ▼
Read by QxMD icon Read
search

BASIC science

keyword
https://www.readbyqxmd.com/read/29678977/minimizing-icu-neurological-dysfunction-with-dexmedetomidine-induced-sleep-mindds-protocol-for-a-randomised-double-blind-parallel-arm-placebo-controlled-trial
#1
Kenneth T Shelton, Jason Qu, Federico Bilotta, Emery N Brown, Gaston Cudemus, David A D'Alessandro, Hao Deng, Alan DiBiasio, Jacob A Gitlin, Eunice Y Hahm, Lauren E Hobbs, Timothy T Houle, Reine Ibala, Marco Loggia, Kara J Pavone, Shahzad Shaefi, George Tolis, M Brandon Westover, Oluwaseun Akeju
INTRODUCTION: Delirium, which is prevalent in postcardiac surgical patients, is an acute brain dysfunction characterised by disturbances in attention, awareness and cognition not explained by a pre-existing neurocognitive disorder. The pathophysiology of delirium remains poorly understood. However, basic science and clinical studies suggest that sleep disturbance may be a modifiable risk factor for the development of delirium. Dexmedetomidine is a α-2A adrenergic receptor agonist medication that patterns the activity of various arousal nuclei similar to sleep...
April 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29676504/3d-dna-origami-nanoparticles-from-basic-design-principles-to-emerging-applications-in-soft-matter-and-bio-nanosciences
#2
Andreas Walther, Sebastian Loescher, Saskia Groeer
Scaffold-based lattice-engineered 3D DNA origami emerges as a powerful and versatile technique for the rational design and built-up of arbitrary and monodisperse DNA-based 3D nanoobjects. Relying on the unsurpassed molecular programmability of sequence-specific DNA hybridization, a long circular ssDNA strand (termed scaffold) is assembled with many short ssDNA oligomers (termed staples), which organize the scaffold into a 3D lattice in a single step leading to highest precision 3D nanoparticulate structures with high yields...
April 20, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29676078/-study-and-thought-on-the-safety-of-traditional-chinese-medicines-under-healthy-china-strategy
#3
Xiao-He Xiao
As the Healthy China planning has been implemented, traditional Chinese medicine (TCM) has witnessed unprecedented developmental opportunities. However, the safety of TCM has always been like The Sword of Damocles in TCM area, endangering the healthy and sustainable development of TCM. In order to solve the problem of TCM safety in China as soon as possible, the author puts forward that the situation and issues of TCM safety should be considered with the change of the times. At the same time, it is suggested that the research on TCM safety should be listed as the most important project in TCM science and technology field...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29675459/bioengineered-systems-and-designer-matrices-that-recapitulate-the-intestinal-stem-cell-niche
#4
REVIEW
Yuli Wang, Raehyun Kim, Samuel S Hinman, Bailey Zwarycz, Scott T Magness, Nancy L Allbritton
The relationship between intestinal stem cells (ISCs) and the surrounding niche environment is complex and dynamic. Key factors localized at the base of the crypt are necessary to promote ISC self-renewal and proliferation, to ultimately provide a constant stream of differentiated cells to maintain the epithelial barrier. These factors diminish as epithelial cells divide, migrate away from the crypt base, differentiate into the postmitotic lineages, and end their life span in approximately 7 days when they are sloughed into the intestinal lumen...
March 2018: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29674941/cosmology-and-fundamental-physics-with-the-euclid-satellite
#5
REVIEW
Luca Amendola, Stephen Appleby, Anastasios Avgoustidis, David Bacon, Tessa Baker, Marco Baldi, Nicola Bartolo, Alain Blanchard, Camille Bonvin, Stefano Borgani, Enzo Branchini, Clare Burrage, Stefano Camera, Carmelita Carbone, Luciano Casarini, Mark Cropper, Claudia de Rham, Jörg P Dietrich, Cinzia Di Porto, Ruth Durrer, Anne Ealet, Pedro G Ferreira, Fabio Finelli, Juan García-Bellido, Tommaso Giannantonio, Luigi Guzzo, Alan Heavens, Lavinia Heisenberg, Catherine Heymans, Henk Hoekstra, Lukas Hollenstein, Rory Holmes, Zhiqi Hwang, Knud Jahnke, Thomas D Kitching, Tomi Koivisto, Martin Kunz, Giuseppe La Vacca, Eric Linder, Marisa March, Valerio Marra, Carlos Martins, Elisabetta Majerotto, Dida Markovic, David Marsh, Federico Marulli, Richard Massey, Yannick Mellier, Francesco Montanari, David F Mota, Nelson J Nunes, Will Percival, Valeria Pettorino, Cristiano Porciani, Claudia Quercellini, Justin Read, Massimiliano Rinaldi, Domenico Sapone, Ignacy Sawicki, Roberto Scaramella, Constantinos Skordis, Fergus Simpson, Andy Taylor, Shaun Thomas, Roberto Trotta, Licia Verde, Filippo Vernizzi, Adrian Vollmer, Yun Wang, Jochen Weller, Tom Zlosnik
Euclid is a European Space Agency medium-class mission selected for launch in 2020 within the cosmic vision 2015-2025 program. The main goal of Euclid is to understand the origin of the accelerated expansion of the universe. Euclid will explore the expansion history of the universe and the evolution of cosmic structures by measuring shapes and red-shifts of galaxies as well as the distribution of clusters of galaxies over a large fraction of the sky. Although the main driver for Euclid is the nature of dark energy, Euclid science covers a vast range of topics, from cosmology to galaxy evolution to planetary research...
2018: Living Reviews in Relativity
https://www.readbyqxmd.com/read/29673874/origins-of-lifetime-health-around-the-time-of-conception-causes-and-consequences
#6
REVIEW
Tom P Fleming, Adam J Watkins, Miguel A Velazquez, John C Mathers, Andrew M Prentice, Judith Stephenson, Mary Barker, Richard Saffery, Chittaranjan S Yajnik, Judith J Eckert, Mark A Hanson, Terrence Forrester, Peter D Gluckman, Keith M Godfrey
Parental environmental factors, including diet, body composition, metabolism, and stress, affect the health and chronic disease risk of people throughout their lives, as captured in the Developmental Origins of Health and Disease concept. Research across the epidemiological, clinical, and basic science fields has identified the period around conception as being crucial for the processes mediating parental influences on the health of the next generation. During this time, from the maturation of gametes through to early embryonic development, parental lifestyle can adversely influence long-term risks of offspring cardiovascular, metabolic, immune, and neurological morbidities, often termed developmental programming...
April 16, 2018: Lancet
https://www.readbyqxmd.com/read/29673581/hoping-for-more-how-cognitive-science-has-and-hasn-t-been-helpful-to-the-ocd-clinician
#7
REVIEW
Allison J Ouimet, Andrea R Ashbaugh, Adam S Radomsky
Cognitive-behavioural models of obsessive-compulsive disorder (OCD) stemmed from knowledge acquired from cognitive science. Researchers continue to apply basic cognitive-affective science methods to understanding OCD, with the overarching goal of improving and refining evidence-based treatments. However, the degree to which such research has contributed to this goal is unclear. We reviewed OCD research in the general areas that comprise basic cognitive science, and evaluated the degree to which it has contributed to our understanding of the development, maintenance, and treatment of OCD...
April 12, 2018: Clinical Psychology Review
https://www.readbyqxmd.com/read/29672914/revisiting-the-nih-taskforce-on-the-research-needs-of-eosinophil-associated-diseases-re-tread
#8
REVIEW
Paneez Khoury, Praveen Akuthota, Steven J Ackerman, Joseph R Arron, Bruce S Bochner, Margaret H Collins, Jean-Emmanuel Kahn, Patricia C Fulkerson, Gerald J Gleich, Rashmi Gopal-Srivastava, Elizabeth A Jacobsen, Kristen M Leiferman, Levi-Schaffer Francesca, Sameer K Mathur, Michael Minnicozzi, Calman Prussin, Marc E Rothenberg, Florence Roufosse, Kathleen Sable, Dagmar Simon, Hans-Uwe Simon, Lisa A Spencer, Jonathan Steinfeld, Andrew J Wardlaw, Michael E Wechsler, Peter F Weller, Amy D Klion
BACKGROUND: Eosinophil-associated diseases (EADs) are rare, heterogeneous disorders characterized by the presence of eosinophils in tissues and/or peripheral blood resulting in immunopathology. The heterogeneity of tissue involvement, lack of sufficient animal models, technical challenges in working with eosinophils, and lack of standardized histopathologic approaches have hampered progress in basic research. Additionally, clinical trials and drug development for rare EADs are limited by the lack of primary and surrogate endpoints, biomarkers, and validated patient-reported outcomes...
April 19, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29670517/computational-models-for-calcium-mediated-astrocyte-functions
#9
REVIEW
Tiina Manninen, Riikka Havela, Marja-Leena Linne
The computational neuroscience field has heavily concentrated on the modeling of neuronal functions, largely ignoring other brain cells, including one type of glial cell, the astrocytes. Despite the short history of modeling astrocytic functions, we were delighted about the hundreds of models developed so far to study the role of astrocytes, most often in calcium dynamics, synchronization, information transfer, and plasticity in vitro , but also in vascular events, hyperexcitability, and homeostasis. Our goal here is to present the state-of-the-art in computational modeling of astrocytes in order to facilitate better understanding of the functions and dynamics of astrocytes in the brain...
2018: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/29669557/discovery-biology-of-neuropsychiatric-syndromes-dbns-a-center-for-integrating-clinical-medicine-and-basic-science
#10
Biju Viswanath, Naren P Rao, Janardhanan C Narayanaswamy, Palanimuthu T Sivakumar, Arun Kandasamy, Muralidharan Kesavan, Urvakhsh Meherwan Mehta, Ganesan Venkatasubramanian, John P John, Odity Mukherjee, Meera Purushottam, Ramakrishnan Kannan, Bhupesh Mehta, Thennarasu Kandavel, B Binukumar, Jitender Saini, Deepak Jayarajan, A Shyamsundar, Sydney Moirangthem, K G Vijay Kumar, Jagadisha Thirthalli, Prabha S Chandra, Bangalore N Gangadhar, Pratima Murthy, Mitradas M Panicker, Upinder S Bhalla, Sumantra Chattarji, Vivek Benegal, Mathew Varghese, Janardhan Y C Reddy, Padinjat Raghu, Mahendra Rao, Sanjeev Jain
BACKGROUND: There is emerging evidence that there are shared genetic, environmental and developmental risk factors in psychiatry, that cut across traditional diagnostic boundaries. With this background, the Discovery biology of neuropsychiatric syndromes (DBNS) proposes to recruit patients from five different syndromes (schizophrenia, bipolar disorder, obsessive compulsive disorder, Alzheimer's dementia and substance use disorders), identify those with multiple affected relatives, and invite these families to participate in this study...
April 18, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29669066/does-health-informatics-have-a-replication-crisis
#11
Enrico Coiera, Elske Ammenwerth, Andrew Georgiou, Farah Magrabi
Objective: Many research fields, including psychology and basic medical sciences, struggle with poor reproducibility of reported studies. Biomedical and health informatics is unlikely to be immune to these challenges. This paper explores replication in informatics and the unique challenges the discipline faces. Methods: Narrative review of recent literature on research replication challenges. Results: While there is growing interest in re-analysis of existing data, experimental replication studies appear uncommon in informatics...
April 13, 2018: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29668075/a-comparison-of-debate-and-role-play-in-enhancing-critical-thinking-and-communication-skills-of-medical-students-during-problem-based-learning
#12
Rabia Latif, Sadaf Mumtaz, Rafia Mumtaz, Aamir Hussain
Debate and role play for learning critical thinking and communication skills are being increasingly used in various undergraduate medical schools worldwide. We aim to compare students' views about effectiveness of two teaching strategies; debate and role play to exercise critical thinking and communication skills during problem-based learning (PBL). This is a comparative, cross-sectional, and questionnaire-based study. Our subjects were second year undergraduate female medical students enrolled in Imam Abdulrahman Bin Faisal University (IAU), College of Medicine from September 2014-2016, divided into 10 small PBL groups (10-13 students/group/year)...
April 18, 2018: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/29666059/vision-for-nci-outlined-by-new-director
#13
(no author information available yet)
Speaking at the American Association for Cancer Research Annual Meeting 2018, Norman "Ned" Sharpless, MD, the new director of the NCI, outlined his vision for the agency and spoke about four areas on which he'd like to focus its efforts: workforce training and development, basic science, "big data," and clinical trials.
April 17, 2018: Cancer Discovery
https://www.readbyqxmd.com/read/29665886/antimicrobial-resistance-from-basic-science-to-translational-innovation
#14
Jun Lin
The rise in antimicrobial resistance (AMR) poses a major threat to animal agriculture and human health. To summarize and update current and emerging AMR issues that are significant for animal health and food safety, this issue presents a virtual AMR symposium consisting of seven review papers. These reviews cover a newly described AMR mechanism in Campylobacter, effects of AMR and microbiome on Campylobacter infection, plasmid-mediated colistin resistance in food-producing animals, the impact of point source or antibiotic residues on the environmental resistome, and potential factors influencing horizontal gene transfer in the intestines of food animals...
December 2017: Animal Health Research Reviews
https://www.readbyqxmd.com/read/29664885/the-effect-of-hip-positioning-on-the-projected-femoral-neck-shaft-angle-a-modeling-study
#15
Abhiram R Bhashyam, Edward K Rodriguez, Paul Appleton, John J Wixted
OBJECTIVES: The femoral neck-shaft angle (NSA) is used to restore normal hip geometry during hip fracture repair. Femoral rotation is known to affect NSA measurement, but the effect of hip flexion-extension is unknown. The goals of this study were to determine and test mathematical models of the relationship between hip flexion-extension, femoral rotation and NSA. We hypothesized that hip flexion-extension and femoral rotation would result in NSA measurement error. METHODS: Two mathematical models were developed to predict NSA in varying degrees of hip flexion-extension and femoral rotation...
April 3, 2018: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/29663387/muscarinic-and-nicotinic-acetylcholine-receptor-agonists-current-scenario-in-alzheimer-s-disease-therapy
#16
REVIEW
Stuti Verma, Ashwini Kumar, Timir Tripathi, Awanish Kumar
OBJECTIVES: Alzheimer's disease (AD) has become the primary cause of dementia. It shows a progressive cognitive dysfunction with degenerating neurons. Acetylcholine receptors (AChRs) propagate the cognitive ability and it consists of two primary members namely muscarinic (mAChRs) and nicotinic receptors (nAChRs). Where mAChRs is G-protein coupled receptor, (nAChRs) are ligand-gated ion channels. The conventional therapeutic regimen for AD consists of three acetylcholinestearse inhibitors while a single NMDA receptor antagonist...
April 16, 2018: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/29663276/interprofessional-educator-development-build-it-and-they-will-come
#17
Lily C Pien, Michaela Stiber, Allison Prelosky, Colleen Y Colbert
BACKGROUND: We describe an interprofessional educator development program, designed intentionally, that was implemented at an academic healthcare centre. In 2014, we purposefully adapted our pre-existing educator development program to be able to include all interprofessional educators at our institution. The program's goals were to enhance educator skills, a common need due to requirements of accreditation, and to create a local interprofessional community of teachers. The framework of the program was based upon adult learning principles, reflective practice, experiential learning and peer groups, all key characteristics of faculty development programs...
April 16, 2018: Perspectives on Medical Education
https://www.readbyqxmd.com/read/29663119/multicenter-data-banking-in-management-of-dizzy-patients-first-results-from-the-dizzynet-registry-project
#18
Eva Grill, Gülden Akdal, Sandra Becker-Bense, Steffen Hübinger, Doreen Huppert, Erna Kentala, Ralf Strobl, Andreas Zwergal, Nese Celebisoy
PURPOSE: Comprehensive phenotypical data across countries is needed to understand the determinants, prognosis and consequences of vestibular disease. The registry is a data repository for the members of the European DizzyNet. We report results from a pilot study using data from Turkey and Germany. METHODS: The pilot study included a convenience sample of patients aged 18 or above referred to Ege University Medical School Hospital, Dokuz Eylül University Hospital, Izmir, Turkey, and the German Center for German Center for Vertigo and Balance Disorders, University on Munich, Germany, with symptoms of vertigo or dizziness...
April 16, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29661689/cardiometabolic-risk-and-female-sexuality-part-ii-understanding-and-overcoming-gender-differences-the-key-role-of-an-adequate-methodological-approach
#19
REVIEW
Elisa Maseroli, Irene Scavello, Linda Vignozzi
INTRODUCTION: Although basic science and clinical research indicate that the vascular physiopathology of male and female sexual dysfunction (FSD) is similar, to date the association between FSD and cardiovascular (CV) diseases has been only marginally explored. AIM: To discuss the potential reasons for differences in the role of CV diseases and risk factors in sexual function in women vs men in the 2nd part of a 2-part review. METHODS: A thorough literature search of peer-reviewed publications on the topic was performed using the PubMed database...
April 13, 2018: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/29661576/treatment-of-experimental-necrotizing-enterocolitis-with-stem-cell-derived-exosomes
#20
Christopher J McCulloh, Jacob K Olson, Yijie Wang, Yu Zhou, Natalie Huibregtse Tengberg, Shivani Deshpande, Gail E Besner
PURPOSE: Necrotizing enterocolitis (NEC) remains a devastating disease in premature infants. We previously showed that four stem cell (SC) types equivalently improve experimental NEC. Exosomes are intercellular nanovesicles containing RNA, miRNA, DNA, and protein. Because SC therapy faces challenges, our aim was to determine if the beneficial effects of SC are achievable with cell-free exosomes. METHODS: Exosomes from four SC types were compared: (1) amniotic fluid-derived mesenchymal SC (AF-MSC); (2) bone marrow-derived MSC (BM-MSC); (3) amniotic fluid-derived neural SC (AF-NSC); and (4) neonatal enteric NSC (E-NSC)...
March 14, 2018: Journal of Pediatric Surgery
keyword
keyword
66052
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"