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https://www.readbyqxmd.com/read/28821982/discussing-euthanasia-in-two-german-states-scientific-terminology-and-public-discourse-in-the-german-democratic-republic-and-the-federal-republic-of-germany
#1
Hartmut Bettin, Andreas Nowak, Maria Gracia Roccia, Sabine Salloch
Discussions on euthanasia ("Sterbehilfe") that took place in the German Democratic Republic (GDR) have remained widely unnoticed by the historical sciences. By referring to various publications dating from the 1950s until today, this paper presents the basic ideas of the debate on euthanasia in the GDR and compares them-partly synchronically, partly diachronically-with the situation in the Federal Republic of Germany (FRG). A special focus is placed on positions and terminology related to medical ethics at the end of life in the former two German states...
August 18, 2017: Wiener Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28817730/new-approach-to-generating-insights-for-aging-research-based-on-literature-mining-and-knowledge-integration
#2
Yeondae Kwon, Yukikazu Natori, Masaru Tanokura
The proportion of the elderly population in most countries worldwide is increasing dramatically. Therefore, social interest in the fields of health, longevity, and anti-aging has been increasing as well. However, the basic research results obtained from a reductionist approach in biology and a bioinformatic approach in genome science have limited usefulness for generating insights on future health, longevity, and anti-aging-related research on a case by case basis. We propose a new approach that uses our literature mining technique and bioinformatics, which lead to a better perspective on research trends by providing an expanded knowledge base to work from...
2017: PloS One
https://www.readbyqxmd.com/read/28816904/the-relationship-between-oref-grants-and-future-nih-funding-success
#3
Vishal Hegde, Daniel Johansen, Howard Y Park, Stephen D Zoller, Christopher Hamad, Nicholas M Bernthal
BACKGROUND: The Orthopaedic Research and Education Foundation (OREF) is the leading specialty-specific nongovernmental organization providing orthopaedic funding in the United States. As extramural research funding has become increasingly difficult to acquire, one mission of the OREF is to support investigators to generate data needed to secure larger extramural funding from agencies such as the National Institutes of Health (NIH). The objectives of this study were to evaluate the rate of translating OREF faculty-level grants into subsequent NIH funding and to determine if there are identifiable factors that increase the rate of converting an OREF grant into NIH funding...
August 16, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28815204/pathology-competencies-for-medical-education-and-educational-cases
#4
Barbara E C Knollmann-Ritschel, Donald P Regula, Michael J Borowitz, Richard Conran, Michael B Prystowsky
Current medical school curricula predominantly facilitate early integration of basic science principles into clinical practice to strengthen diagnostic skills and the ability to make treatment decisions. In addition, they promote life-long learning and understanding of the principles of medical practice. The Pathology Competencies for Medical Education (PCME) were developed in response to a call to action by pathology course directors nationwide to teach medical students pathology principles necessary for the practice of medicine...
January 2017: Acad Pathol
https://www.readbyqxmd.com/read/28814732/dual-contrast-magnetic-resonance-fingerprinting-dc-mrf-a-platform-for-simultaneous-quantification-of-multiple-mri-contrast-agents
#5
Christian E Anderson, Shannon B Donnola, Yun Jiang, Joshua Batesole, Rebecca Darrah, Mitchell L Drumm, Susann M Brady-Kalnay, Nicole F Steinmetz, Xin Yu, Mark A Griswold, Chris A Flask
Injectable Magnetic Resonance Imaging (MRI) contrast agents have been widely used to provide critical assessments of disease for both clinical and basic science imaging research studies. The scope of available MRI contrast agents has expanded over the years with the emergence of molecular imaging contrast agents specifically targeted to biological markers. Unfortunately, synergistic application of more than a single molecular contrast agent has been limited by MRI's ability to only dynamically measure a single agent at a time...
August 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28814473/breaking-boundaries-optimizing-reconsolidation-based-interventions-for-strong-and-old-memories
#6
James W B Elsey, Merel Kindt
Recent research has demonstrated that consolidated memories can enter a temporary labile state after reactivation, requiring restabilization in order to persist. This process, known as reconsolidation, potentially allows for the modification and disruption of memory. Much interest in reconsolidation stems from the possibility that maladaptive memory traces-a core feature of several psychiatric conditions-could be tackled by disrupting their reconsolidation. However, research has indicated a range of supposed boundary conditions on the induction of reconsolidation...
September 2017: Learning & Memory
https://www.readbyqxmd.com/read/28811801/pakistan-journal-of-medical-sciences-a-bibliometric-assessment-2001-2010
#7
Zameer Hussain Baladi, Loung V Umedani
OBJECTIVE: The aim of this study was to measure the growth of scientific research, authors' productivity, affiliation with the institute and geographic locations published in the Pakistan Journal of Medical Sciences during the period of 2001 - 2010. METHODS: This numerical analysis was conducted during mid-August 2016 to mid-October, 2016. The data for the study was downloaded from websites of e-journal of Pakistan Journal of Medical Sciences (PJMS) and Pak Medi-Net Com...
May 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28811201/the-unmet-need-in-rheumatology-reports-from-the-targeted-therapies-meeting-2017
#8
Kevin L Winthrop, Vibeke Strand, Désirée van der Heijde, Philip Mease, Mary Crow, Michael Weinblatt, Joan Bathon, Gerd R Burmester, Maxime Dougados, Johnathan Kay, Xavier Mariette, Ronald Van Vollenhoven, Joachim Sieper, Fritz Melchers, Ferdinand C Breedfeld, Joachim Kalden, Josef S Smolen, Daniel E Furst
The 19th annual international Targeted Therapies meeting brought together over 100 leading basic scientists and clinical researchers from around the world in the field of immunology, molecular biology and rheumatology and other specialties. During the meeting, breakout sessions were held consisting of 5 disease-specific groups with 20-40 experts assigned to each group based on clinical or scientific expertise. Specific groups included: rheumatoid arthritis, psoriatic arthritis, axial spondyloarthritis, systemic lupus erythematous, connective tissue diseases (e...
August 12, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/28811043/treatment-of-the-fixation-surface-improves-glenoid-prosthesis-longevity-in-vitro
#9
Sarah Junaid, Sanjay Sanghavi, Carolyn Anglin, Anthony Bull, Roger Emery, Andrew A Amis, Ulrich Hansen
Many commercial cemented glenoid components claim superior fixation designs and increased survivability. However, both research and clinical studies have shown conflicting results and it is unclear whether these design variations do improve loosening rates. Part of the difficulty in investigating fixation failure is the inability to directly observe the fixation interface, a problem addressed in this study by using a novel experimental set-up. Cyclic loading-displacement tests were carried out on 60 custom-made glenoid prostheses implanted into a bone substitute...
July 22, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28810716/basic-science-and-cardiology-ii-funding
#10
Judy Ozkan
No abstract text is available yet for this article.
August 1, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28810715/basic-science-and-cardiology-i-basics
#11
Judy Ozkan
No abstract text is available yet for this article.
August 1, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28807985/inhaled-carbon-monoxide-from-toxin-to-therapy
#12
Dean R Hess
Carbon monoxide (CO) is usually recognized as a toxic gas that can be used to assess lung function in the pulmonary function laboratory. The toxicity of CO relates to its high affinity for hemoglobin and other heme molecules, producing carboxyhemoglobin (HbCO). Despite that blood HbCO levels are commonly measured in patients with CO poisoning, the clinical presentation often does not correlate with the HbCO level, and clinical improvement in the patient's condition does not correlate with HbCO clearance. In patients with CO poisoning, administration of 100% O2 is standard practice...
August 14, 2017: Respiratory Care
https://www.readbyqxmd.com/read/28805520/pace-team-response-shows-a-disregard-for-the-principles-of-science
#13
Jonathan Edwards
The PACE trial of cognitive behavioural therapy and graded exercise therapy for chronic fatigue syndrome/myalgic encephalomyelitis has raised serious questions about research methodology. An editorial article by Geraghty gives a fair account of the problems involved, if anything understating the case. The response by White et al. fails to address the key design flaw, of an unblinded study with subjective outcome measures, apparently demonstrating a lack of understanding of basic trial design requirements. The failure of the academic community to recognise the weakness of trials of this type suggests that a major overhaul of quality control is needed...
August 2017: Journal of Health Psychology
https://www.readbyqxmd.com/read/28804806/how-biological-background-assumptions-influence-scientific-risk-evaluation-of-stacked-genetically-modified-plants-an-analysis-of-research-hypotheses-and-argumentations
#14
Elena Rocca, Fredrik Andersen
Scientific risk evaluations are constructed by specific evidence, value judgements and biological background assumptions. The latter are the framework-setting suppositions we apply in order to understand some new phenomenon. That background assumptions co-determine choice of methodology, data interpretation, and choice of relevant evidence is an uncontroversial claim in modern basic science. Furthermore, it is commonly accepted that, unless explicated, disagreements in background assumptions can lead to misunderstanding as well as miscommunication...
August 14, 2017: Life Sciences, Society and Policy
https://www.readbyqxmd.com/read/28804526/solid-state-ionics-a-japan-perspective
#15
Osamu Yamamoto
The 70-year history of scientific endeavor of solid state ionics research in Japan is reviewed to show the contribution of Japanese scientists to the basic science of solid state ionics and its applications. The term 'solid state ionics' was defined by Takehiko Takahashi of Nagoya University, Japan: it refers to ions in solids, especially solids that exhibit high ionic conductivity at a fairly low temperature below their melting points. During the last few decades of exploration, many ion conducting solids have been discovered in Japan such as the copper-ion conductor Rb4Cu16I7Cl13, proton conductor SrCe1-x Y x O3, oxide-ion conductor La0...
2017: Science and Technology of Advanced Materials
https://www.readbyqxmd.com/read/28803534/moving-rehabilitation-research-forward-developing-consensus-statements-for-rehabilitation-and-recovery-research
#16
Julie Bernhardt, Karen Borschmann, Lara Boyd, S Thomas Carmichael, Dale Corbett, Steven C Cramer, Tammy Hoffmann, Gert Kwakkel, Sean Savitz, Gustavo Saposnik, Marion Walker, Nick Ward
Stroke recovery is the next frontier in stroke medicine. While growth in rehabilitation and recovery research is exponential, a number of barriers hamper our ability to rapidly progress the field. Standardized terminology is absent in both animal and human research, methods are poorly described, recovery biomarkers are not well defined, and we lack consistent timeframes or measures to examine outcomes. Agreed methods and conventions for developing, monitoring, evaluating and reporting interventions directed at improving recovery are lacking, and current approaches are often not underpinned by biology...
August 2017: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/28803050/the-arest-cf-experience-in-biobanking-more-than-just-tissues-tubes-and-time
#17
Luke W Garratt, Anthony Kicic, Colin Robertson, Sarath Ranganathan, Peter D Sly, Stephen M Stick
Research to further improve outcomes for people with CF is dependent upon well characterised, archived and accessible clinical specimens. The recent article by Beekman et al. published in Journal of Cystic Fibrosis summarised a scientific meeting at the 13th ECFS Basic Science Conference. This meeting discussed how well-annotated, clinical biobanks for CF could be established in Europe to meet the needs of therapeutic development. The Australian Respiratory Early Surveillance Team for Cystic Fibrosis (AREST CF) has conducted biobanking of CF research and clinical specimens since the late 1990s and is custodian of the most comprehensive paediatric CF biobank in the world that focuses on the first years of life...
August 9, 2017: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/28802532/challenges-and-controversies-in-hypertrophic-cardiomyopathy-clinical-genomic-and-basic-science-perspectives
#18
Ares Pasipoularides
No abstract text is available yet for this article.
August 9, 2017: Revista Española de Cardiología
https://www.readbyqxmd.com/read/28802451/more-than-the-useful-field-considering-peripheral-vision-in-driving
#19
REVIEW
Benjamin Wolfe, Jonathan Dobres, Ruth Rosenholtz, Bryan Reimer
Applied research on driving and basic vision research have held similar views on central, fovea-based vision as the core of visual perception. In applied work, the concept of the Useful Field, as determined by the Useful Field of View (UFOV) test, divides vision between a "useful" region towards the center of the visual field, and the rest of the visual field. While compelling, this dichotomization is at odds with findings in vision science which demonstrate the capabilities of peripheral vision. In this paper, we examine driving research from this new perspective, and argue for the need for an updated understanding of how drivers acquire information about their operating environment using peripheral vision...
November 2017: Applied Ergonomics
https://www.readbyqxmd.com/read/28801526/an-update-on-hormone-therapy-in-postmenopausal-women-mini-review-for-the-basic-scientist
#20
Virginia M Miller, S Mitchell Harman
The worlds of observational, clinical and basic science collided in 2002 with the publication of results of the Women's Health Initiative (WHI), a large scale, prospective, blinded, randomized-controlled trial designed to provide evidence regarding use of hormone treatment to prevent cardiovascular disease in menopausal women. The results of the WHI dramatically changed clinical practice, negatively impacted funding for hormone research and left scientists to unravel the "why" of the results. Now over a decade and a half since the initial publication of the WHI results, basic and clinical scientists often do not interpret the results of the WHI with the precision needed to move the science forward...
August 11, 2017: American Journal of Physiology. Heart and Circulatory Physiology
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