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https://www.readbyqxmd.com/read/29931268/placenta-to-the-rescue-limb-salvage-using-dehydrated-human-amnion-chorion-membrane
#1
Victoria Schlanser, Andrew Dennis, Katarina Ivkovic, Kimberly Joseph, Matthew Kaminsky, Thomas Messer, Stathis Poulakidas, Frederic Starr, Faran Bokhari
Reconstruction of skin and soft tissue wounds can pose a unique surgical challenge. This is especially true for cases of exposed bone and tendon where soft tissue loss is extensive and opportunities for tissue advancement or rotation are limited. A clinical case is presented describing an experience with dehydrated human amnion/chorion membrane (dHACM, EpiFix®/AmnioFix®, MiMedx Group, Marietta, GA) graft to obtain granulation over an open fracture with desiccated bone. The 22-year-old female trauma patient presented with high-grade bilateral lower extremity soft tissue loss after being run over and dragged by a semitruck...
December 5, 2017: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/29929403/biomechanical-properties-of-the-repaired-and-non-repaired-rat-supraspinatus-tendon-in-the-acute-postoperative-period
#2
Michael D Kurdziel, Abigail Davidson, David Ross, Joseph Seta, Shashin Doshi, Kevin C Baker, Tristan Maerz
PURPOSE: The rat rotator cuff (RC) model is used to study RC pathology and potential treatment, however, native scar-mediated healing allows the rat RC to recover at 4-6 weeks but little is known about acute healing. This study characterized the properties of the repaired and non-repaired rat RC following surgical detachment. MATERIALS AND METHODS: Forty-eight rats underwent surgical RC detachment and received surgical repair (Repair) or left unrepaired (Defect)to either 12 or 19 days...
June 22, 2018: Connective Tissue Research
https://www.readbyqxmd.com/read/29924004/diffuse-giant-cell-tumors-of-the-tendon-sheath-in-temporomandibular-joint-two-case-reports-and-review-of-the-literature
#3
Hong Yan, Furong Wang, Lin Xiang, Wei Zhu, Cheng Liang
RATIONALE: Diffuse giant cell tumors of the tendon sheath (GCT-TS) in the temporomandibular joint (TMJ) are extremely rare. PATIENT CONCERNS: We reported the imaging appearance and the pathological findings of 2 male cases with diffuse GCT-TS in the TMJ (52 years for the case 1 and 50 years for the case 2) who complain of the hearing disorders of left ear when presenting to our hospital. DIAGNOSIS: Preoperative computerized tomography (CT) scan revealed an irregular mass in the left temporal fossa with the sizes of approximately 5...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29922457/the-effects-of-high-glucose-condition-on-rat-tenocytes-in-vitro-and-rat-achilles-tendon-in-vivo
#4
Y Ueda, A Inui, Y Mifune, R Sakata, T Muto, Y Harada, F Takase, T Kataoka, T Kokubu, R Kuroda
Objectives: The aim of this study was to investigate the effect of hyperglycaemia on oxidative stress markers and inflammatory and matrix gene expression within tendons of normal and diabetic rats and to give insights into the processes involved in tendinopathy. Methods: Using tenocytes from normal Sprague-Dawley rats, cultured both in control and high glucose conditions, reactive oxygen species (ROS) production, cell proliferation, messenger RNA (mRNA) expression of NADPH oxidase (NOX) 1 and 4, interleukin-6 (IL-6), matrix metalloproteinase (MMP)-2, tissue inhibitors of matrix metalloproteinase (TIMP)-1 and -2 and type I and III collagens were determined after 48 and 72 hours in vitro ...
May 2018: Bone & Joint Research
https://www.readbyqxmd.com/read/29922452/the-effect-of-femoral-bone-tunnel-configuration-on-tendon-bone-healing-in-an-anterior-cruciate-ligament-reconstruction-an-animal-study
#5
Y Sato, R Akagi, Y Akatsu, Y Matsuura, S Takahashi, S Yamaguchi, T Enomoto, R Nakagawa, H Hoshi, T Sasaki, S Kimura, Y Ogawa, A Sadamasu, S Ohtori, T Sasho
Objectives: To compare the effect of femoral bone tunnel configuration on tendon-bone healing in an anterior cruciate ligament (ACL) reconstruction animal model. Methods: Anterior cruciate ligament reconstruction using the plantaris tendon as graft material was performed on both knees of 24 rabbits (48 knees) to mimic ACL reconstruction by two different suspensory fixation devices for graft fixation. For the adjustable fixation device model (Socket group; group S), a 5 mm deep socket was created in the lateral femoral condyle (LFC) of the right knee...
May 2018: Bone & Joint Research
https://www.readbyqxmd.com/read/29922450/tissue-engineering-strategies-for-the-treatment-of-tendon-injuries-a-systematic-review-and-meta-analysis-of-animal-models
#6
D González-Quevedo, I Martínez-Medina, A Campos, F Campos, V Carriel
Objectives: Recently, the field of tissue engineering has made numerous advances towards achieving artificial tendon substitutes with excellent mechanical and histological properties, and has had some promising experimental results. The purpose of this systematic review is to assess the efficacy of tissue engineering in the treatment of tendon injuries. Methods: We searched MEDLINE, Embase, and the Cochrane Library for the time period 1999 to 2016 for trials investigating tissue engineering used to improve tendon healing in animal models...
April 2018: Bone & Joint Research
https://www.readbyqxmd.com/read/29922283/whodunit-the-contribution-of-interleukin-il-17-il-22-producing-%C3%AE-%C3%AE-t-cells-%C3%AE-%C3%AE-t-cells-and-innate-lymphoid-cells-to-the-pathogenesis-of-spondyloarthritis
#7
REVIEW
Annika Reinhardt, Immo Prinz
γδ T cells, αβ T cells, and innate lymphoid cells (ILCs) are capable of producing interleukin (IL)-17A, IL-17F, and IL-22. Among these three families of lymphocytes, it is emerging that γδ T cells are, at least in rodents, the main source of these key pro-inflammatory cytokines. γδ T cells were implicated in multiple inflammatory and autoimmune diseases, including psoriasis, experimental autoimmune encephalomyelitis and uveitis, colitis, and rheumatoid arthritis. Recent findings pointed toward a central role of γδ T cells in the pathogenesis of spondyloarthritis (SpA), a group of inflammatory rheumatic diseases affecting the axial skeleton...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29921317/bone-marrow-mesenchymal-stem-cells-do-not-enhance-intra-synovial-tendon-healing-despite-engraftment-and-homing-to-niches-within-the-synovium
#8
Mohammad R Khan, Jayesh Dudhia, Frederic H David, Roberta De Godoy, Vedika Mehra, Gillian Hughes, Stephanie G Dakin, Andrew J Carr, Allen E Goodship, Roger K W Smith
BACKGROUND: Intra-synovial tendon injuries display poor healing, which often results in reduced functionality and pain. A lack of effective therapeutic options has led to experimental approaches to augment natural tendon repair with autologous mesenchymal stem cells (MSCs) although the effects of the intra-synovial environment on the distribution, engraftment and functionality of implanted MSCs is not known. This study utilised a novel sheep model which, although in an anatomically different location, more accurately mimics the mechanical and synovial environment of the human rotator cuff, to determine the effects of intra-synovial implantation of MSCs...
June 19, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29913431/five-decade-delayed-closed-flexor-tendon-rupture-due-to-galeazzi-dislocation-fracture-associated-with-beh%C3%A3-et-syndrome-a-case-report
#9
Masato Ohara, Ryo Oda, Shogo Toyama, Yusei Katsuyama, Hiroyoshi Fujiwara, Toshikazu Kubo
INTRODUCTION: Closed flexor tendon rupture after a malunited distal radius fracture is rare and usually becomes apparent early after the fracture. Most cases are accompanied by a severe distal radio-ulnar joint capsule injury, wherein bone protrusion (as a spur) directly stresses the tendons. We experienced a nonspecific flexor tendon rupture associated with an old fracture and the presence of collagen disease. PRESENTATION OF CASE: A 63-year-old woman presented with delayed complete rupture of the flexor digitorum profundus (FDP) of the fifth digit...
May 29, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29907517/analysis-of-technical-feasibility-and-neurovascular-safety-of-endoscopic-distal-biceps-repair-a-cadaveric-study
#10
Deepak N Bhatia, Vikram Kandhari
BACKGROUND: This cadaveric study was designed to analyze the safety of endoscopic repair of distal biceps tendon (DBT) tears using 2 reattachment techniques. We evaluated the proximity of neurovascular structures to endoscopy portals; iatrogenic injury to neurovascular, musculotendinous, and osseous structures; and changes in compartment pressures. We hypothesized that an all-endoscopic repair of the ruptured DBT would be technically safe and the risk of iatrogenic injury would be low...
June 12, 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29905056/-research-progress-of-porous-tantalum-in-bone-tissue-engineering
#11
REVIEW
Xiaoquan Ding, Xingwang Liu, Jun Chen, Shiyi Chen
Objective : To review the basical research progress of porous tantalum in bone tissue engineering. Methods: The related basical research in fabrication, cytobiology, and surface modification of porous tantalum was reviewed and analyzed. Results: The outstanding physiochemical properties of porous tantalum granted its excellent performance in biocompatibility and osteointegration, as well as promoting cartilage and tendon tissue restoration...
June 1, 2018: Chinese Journal of Reparative and Reconstructive Surgery
https://www.readbyqxmd.com/read/29903498/betti-number-ratios-as-quantitative-indices-for-bone-morphometry-in-three-dimensions
#12
Takashi Teramoto, Takeshi Kamiya, Taira Sakurai, Fuminori Kanaya
BACKGROUND AND OBJECTIVE: Computational homology is an emerging mathematical tool for characterizing shapes of data. In this work, we present a methodology using computational homology for obtaining quantitative measurements of the connectivity in bone morphometry. We introduce the Betti number ratios as novel morphological descriptor for the classification of bone fine structures in three dimensions. METHODS: A total of 51 Japanese white rabbits were used to investigate the connectivity of bone trabeculae after the administration of alendronate in a tendon graft model in rabbits...
August 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29901593/finite-element-based-3d-computer-modeling-for-personalized-treatment-planning-in-clubfoot-deformity-case-report-with-technique-description
#13
Horea Gozar, Zoltan Derzsi, Alexandru Chira, Örs Nagy, Theodora Benedek
RATIONALE: In clubfoot deformity, planning of corrective treatment requires a complex understanding of the foot anatomy, as well as of the geometry and distribution of altered mechanical forces acting at the level of the deformed foot. At the same time, treatment success depends largely on the selection of the most appropriate shape and angles of the customized orthesis developed for foot correction. Therefore, a complex assessment of the intensity and distribution of the mechanical forces at this site is mandatory prior to initiation of any corrective therapy...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29898646/pure-bone-marrow-aspirate-injection-for-chronic-greater-trochanteric-pain-syndrome-a-case-report
#14
Rachel G Henderson, Ricardo E Colberg
There are limited treatment options for patients with a chronic refractory greater trochanteric pain syndrome. Orthobiologic interventions may stimulate tendon healing and improve pain and function in patients who fail the standard conservative treatment. Since the US FDA's new position statement regarding the centrifugation of bone marrow aspirate products as a potentially 'more than minimally manipulated' product, there is a growing concern about the most common bone marrow aspirate concentrate technique...
July 1, 2018: Pain Management
https://www.readbyqxmd.com/read/29897097/improved-tendon-healing-using-bfgf-bmp-12-and-tgf%C3%AE-1-in-a-rat-model
#15
M Majewski, P Heisterbach, C Jaquiéry, L Dürselen, A Todorov, I Martin, C H Evans, S A Müller
Several growth factors (GFs) are expressed as tendons heal, but it remains unknown whether their combined application enhances the healing process. This matter was addressed by applying a combination of basic fibroblast growth factor (bFGF), bone morphogenetic protein 12 (BMP-12) and transforming growth factor beta 1 (TGFβ1) in a rat Achilles tendon transection model. GFs were applied in one of the three following ways: i) direct application of all three factors at the time of surgery; ii) sequential, tiered percutaneous injection of individual factors immediately after surgery, 48 h and 96 h later; iii) load of all three factors onto a collagen sponge implanted at the time of surgery...
June 13, 2018: European Cells & Materials
https://www.readbyqxmd.com/read/29896020/biomechanical-assessment-of-an-alternative-method-of-staple-fixation-for-anchoring-the-bone-patellar-tendon-bone-graft-to-the-tibia
#16
Thomas Matthai, Vinu M George, Anbu S Rao, Anil T Oommen, Ravi J Korula, Suresh Devasahayam, Pradeep M Poonnoose
Introduction: The Anterior cruciate ligament (ACL) is the most commonly injured ligament around the knee and is best reconstructed with a biological graft. For ideal graft fixation, there should be sufficient initial strength to avoid failure of fixation and sufficient stiffness to restore the stability of the knee and to avoid gradual loosening in the post-operative period.When considering fixation of Bone Patellar Tendon Bone (BPTB) grafts to the tibia, the interference screw is considered to be the gold standard...
April 2018: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/29896012/femoral-press-fit-fixation-versus-interference-screw-fixation-in-anterior-cruciate-ligament-reconstruction-with-bone-patellar-tendon-bone-autograft-20-year-follow-up
#17
A Biazzo, A Manzotti, K Motavalli, N Confalonieri
Introduction: The aim of this paper is to present our experience with femoral press-fit fixation in anterior cruciate ligament reconstruction using bone-patellar tendon-bone autograft. Methods: The patient population was randomly placed in two groups: group A (58 patients), who underwent femoral screw fixation; group B (62 patients), who underwent femoral press-fit fixation. Results: At last follow-up 9.2% of patients were lost; 28% of patients in group A and 64% of patients in group B had excellent International Knee Documentation Committee score (grade A); 66% of patients in group A and 32% of patients in group B had good International Knee Documentation Committee scores (grade B)...
April 2018: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/29891130/anatomic-basis-for-minimally-invasive-flexor-hallucis-longus-transfer-in-chronic-achilles-tendon-rupture
#18
Choon Chiet Hong, Wei Ting Lee, Diarmuid Paul Murphy, Ken Jin Tan
The present cadaveric study was designed to measure the flexor hallucis longus (FHL) tendon length and obtain anatomic data regarding the graft-to-tunnel length ratio in an interference screw fixation model for the FHL short-harvest single-incision technique to the calcaneus. Ten fresh-frozen paired cadaveric specimens were used for the FHL short-harvest technique. The length of the osseous tunnel in the calcaneus was measured. At harvesting of the FHL tendon, the length of the tendon that traverses the osseous tunnel was measured with the ankle in neutral and maximal plantarflexion from the tip of the osseous tunnel to the transected end of the tendon within the bone tunnel...
June 8, 2018: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29890893/anatomic-reconstruction-of-anterior-talofibular-ligament-with-tibial-tuberosity-patellar-tendon-autograft-for-chronic-lateral-ankle-instability
#19
Can Chen, Hongbin Lu, Jianzhong Hu, Xuqiang Qiu, Xiong Li, Deyi Sun, Jin Qu, Tao Zhang, Daqi Xu
INTRODUCTION: Anatomic repair of the anterior talofibular ligament (ATFL) is challenging when the local ligamentous tissue is severely attenuated. Anatomic reconstruction of the ATFL with tibial tuberosity-patellar tendon (TT-PT) autograft is a feasible choice that can avoid the complicated tendon-bone healing and restore ankle stability. MATERIALS AND METHODS: From 2009 to 2015, 31 chronic lateral ankle instability (CLAI) patients (31 ankles), who had a serious injury on the ATFL only, were treated with anatomic reconstruction of ATFL with TT-PT...
May 2018: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/29889968/epidemiologic-evidence-and-possible-mechanisms-for-the-association-between-cigarette-smoking-and-injuries-part-2-is-the-relationship-between-smoking-and-injuries-causal
#20
Joseph J Knapik, Sheryl A Bedno
Part 1 of this series reviewed the epidemiologic evidence for the association between cigarette smoking and injuries and possible biological and psychosocial mechanisms to account for this relationship. In the present article, nine criteria are explored to determine if smoking is a direct cause of injuries (i.e., a causal relationship). There is substantial evidence that individuals who smoked in the past have a higher subsequent risk of injury. A recent meta-analysis found that smokers in the military were 1...
2018: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
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