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https://www.readbyqxmd.com/read/28932752/local-rhbmp-12-on-an-absorbable-collagen-sponge-as-an-adjuvant-therapy-for-rotator-cuff-repair-a-phase-1-randomized-standard-of-care-control-multicenter-study-part-2-a-pilot-study-of-functional-recovery-and-structural-outcomes
#1
Junji Ide, Yu Mochizuki, Arthur van Noort, Hiroshi Ochi, Sudhakar Sridharan, Eiji Itoi, Stefan Greiner
BACKGROUND: The high failure rate of rotator cuff repairs requires the development of methods to enhance healing at the tendon-bone junction of the repair site. PURPOSE: To assess functional recovery and structural outcomes in detail after implanting recombinant human bone morphogenetic protein-12 (rhBMP-12)/absorbable collagen sponge (ACS) as adjuvant treatment during open rotator cuff repair in patients over a 1-year postoperative follow-up. STUDY DESIGN: Randomized controlled trial; Level of evidence, 2...
September 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28919510/magnesium-mg-based-interference-screws-developed-for-promoting-tendon-graft-incorporation-in-bone-tunnel-in-rabbits
#2
Jiali Wang, Jiankun Xu, Bin Song, Dick Hokiu Chow, Patrick Shu-Hang Yung, Ling Qin
How to enhance tendon graft incorporation into bone tunnels for achieving satisfactory healing outcomes in patients with anterior cruciate ligament reconstruction (ACLR) is one of the most challenging clinical problems in orthopaedic sports medicine. Several studies have recently reported the beneficial effects of Mg implants in bone fracture healing, indicating the use potential of Mg devices in promoting the tendon graft osteointegration. Here, we developed an innovative Mg-based interference screws for fixation of the tendon graft in rabbits underwent ACLR and investigated the biological role of Mg-based implants in the graft healing...
September 14, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28919185/epidemiology-of-cervical-spine-injuries-in-high-school-athletes-over-a-ten-year-period
#3
Adele Meron, Christopher McMullen, Scott R Laker, Dustin Currie, R Dawn Comstock
BACKGROUND: Over 7 million athletes participate in high school (HS) sports annually, with both the benefits of physical activity and risks of injury. While catastrophic cervical spine injuries have been studied, limited data are available characterizing less severe cervical spine injuries in HS athletes. OBJECTIVE: To describe and compare cervical spine injury rates and patterns among United States (US) HS athletes across 24 sports over a ten-year period. DESIGN: Descriptive epidemiology study SETTING: National sample of high schools participating in the High School Reporting Information Online (High School RIO) injury surveillance system...
September 12, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28916837/primary-and-secondary-consequences-of-rotator-cuff-injury-on-joint-stabilizing-tissues-in-the-shoulder
#4
Hafizur Rahman, Eric Currier, Marshall Johnson, Rick Goding, Amy J Wagoner Johnson, Mariana Kersh
Rotator cuff tears are one of the primary causes of shoulder pain and dysfunction in the upper extremity accounting over 4.5 million physician visits per year with 250,000 rotator cuff repairs being performed annually in the United States. While the tear is often considered an injury to a specific tendon/tendons and consequently treated as such, there are secondary effects of rotator cuff tears that may have significant consequences for shoulder function. Specifically, rotator cuff tears have been shown to affect the joint cartilage, bone, the ligaments, as well as the remaining intact tendons of the shoulder joint...
September 16, 2017: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/28914665/role-of-a-tendon-transfer-as-a-dynamic-checkrein-reducing-recurrence-of-equinus-following-distal-tibial-dorsiflexion-osteotomy
#5
Shahbaz S Malik, Richard Knight, Usman Ahmed, Hari Prem
Tibial dorsiflexion osteotomy for recalcitrant equinus in clubfeet is reported to have a high recurrence rate with growth. We present the results of closing wedge tibial dorsiflexion osteotomy and tendon transfers in 15 feet and 11 patients. The mean age at presentation was 7 (range: 3.98-12.38) years. At a mean follow-up of 4.16 (range: 2.09-6.87) years, 11 of the 15 feet remained corrected. Mean correction of the dorsiflexion was 24.5° and mean correction of anterior distal tibial angle was 10.9° at final review...
September 13, 2017: Journal of Pediatric Orthopedics. Part B
https://www.readbyqxmd.com/read/28913879/short-t2-imaging-using-a-3d-double-adiabatic-inversion-recovery-prepared-ultrashort-echo-time-cones-3d-dir-ute-cones-sequence
#6
Ya-Jun Ma, Yanchun Zhu, Xing Lu, Michael Carl, Eric Y Chang, Jiang Du
PURPOSE: To investigate high contrast imaging of short T2 tissues with a three-dimensional double adiabatic inversion recovery prepared ultrashort echo time Cones (3D DIR-UTE-Cones) sequence. METHODS: The sequence used two sequential adiabatic inversion pulses to suppress signals from long T2 tissues, followed by multispoke UTE acquisition to detect signals from short T2 tissues. The two adiabatic inversion pulses are identical with a center frequency located at the water peak, but the spectral width is broad enough to cover both water and fat frequencies...
September 14, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28905242/poly-n-acetyl-glucosamine-snag-enhances-early-rotator-cuff-tendon-healing-in-a-rat-model
#7
C A Nuss, J Huegel, J F Boorman-Padgett, D S Choi, S N Weiss, J Vournakis, L J Soslowsky
Rotator cuff injuries frequently require surgical repairs which have a high failure rate. Biological augmentation has been utilized in an attempt to improve tendon repair. Poly-N-acetyl glucosamine (sNAG) polymer containing nanofibers has been shown to increase the rate for healing of venous leg ulcers. The purpose of this study was to investigate the healing and analgesic properties of sNAG in a rat rotator cuff injury and repair model. 144 adult male Sprague-Dawley rats underwent a transection and repair of their left supraspinatus tendons...
September 13, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28902469/time-dependent-changes-in-the-structure-of-calcified-fibrocartilage-in-the-rat-achilles-tendon-bone-interface-with-sciatic-denervation
#8
Hideaki Takahashi, Hiroyuki Tamaki, Mineo Oyama, Noriaki Yamamoto, Hideaki Onishi
The enthesis transmits a physiological load from soft to hard tissue via fibrocartilage. The histological alterations induced by this physiological loading remain unclear. This study was performed to examine the histomorphological alterations in the collagen fiber bundle alignment and depth of collagen interdigitation between the calcified fibrocartilage and the bone. We examined the Achilles enthesis of rats with sciatic denervation to explore the mechanical effects of structural changes in the enthesis. The parallelism of the collagen fiber bundles was significantly reduced 8 weeks after denervation...
September 13, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/28902035/small-particle-hyaluronic-acid-gel-treatment-of-photoaged-hands
#9
Eric C Wilkerson, David J Goldberg
BACKGROUND: Aging hands tend to lose subcutaneous volume resulting in prominence of the underlying vessels, tendons, and bone contributing to an aged appearance. Dermal fillers have been successfully used to improve the appearance of the aging dorsal hand. OBJECTIVE: The objective is to evaluate the safety and efficacy of a small-particle hyaluronic acid (SPHA) injectable gel for the treatment of photoaged volume loss of the hands. MATERIALS AND METHODS: This is an open-label, prospective, randomized, interventional, study...
September 4, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28900555/the-utility-of-dual-energy-computed-tomography-in-musculoskeletal-imaging
#10
REVIEW
Sachin Khanduri, Aakshit Goyal, Bhumika Singh, Mriganki Chaudhary, Tushar Sabharwal, Shreshtha Jain, Hritik Sharma
The objective of this article is to review the mechanisms, advantages and disadvantages of dual energy computed tomography (DECT) over conventional tomography (CT) in musculoskeletal imaging as DECT provides additional information about tissue composition and artifact reduction. This provides clinical utility in detection of urate crystals, bone marrow edema, reduction of beam hardening metallic artifact, and ligament and tendon analysis.
2017: Journal of Clinical Imaging Science
https://www.readbyqxmd.com/read/28890904/thirty-year-experience-with-acl-reconstruction-using-patellar-tendon-a-critical-evaluation-of-revision-and-reoperation
#11
Andrew J Riff, Timothy J Luchetti, Alexander E Weber, Jaskarndip Chahal, Bernard R Bach
BACKGROUND: During the preoperative discussion prior to anterior cruciate ligament reconstruction (ACLR), patients are often interested in data regarding rates of revision reconstruction, reoperation, concomitant pathologic changes, and future contralateral ACL injury. PURPOSE: To analyze a single surgeon's experience with primary and revision ACLR over a 30-year interval, focusing on incidence and risk factors for revision and reoperation. STUDY DESIGN: Case series; Level of evidence, 4...
August 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28889228/intraosseous-migration-of-tendinous-calcifications-two-case-reports
#12
A Marinetti, M Sessa, A Falzone, S W Della Sala
Calcific tendinopathy of the rotator cuff is a common cause of shoulder pain. Inflammation of the rotator cuff tendons may be complicated by adjacent bone erosion and subsequent migration of calcific deposits within the bone resulting in marrow inflammation. Bone marrow involvement is not readily visible using X-ray and ultrasound (US) and further testing is necessary. Magnetic resonance imaging (MRI) is a highly sensitive technique that can detect a focal bone T1 and T2-weighted hypointensity with bone marrow edema-like signal and cortical erosion...
September 9, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28886203/a-novel-method-for-repeatable-failure-testing-of-annulus-fibrosus
#13
Benjamin Werbner, Minhao Zhou, Grace O'Connell
Tears in the annulus fibrosus (AF) of the intervertebral disc can result in herniation of the nucleus pulposus and progressive disc degeneration. Understanding AF failure mechanics is particularly important as research moves towards developing biological repair strategies for herniated discs. Unfortunately, failure mechanics of fiber-reinforced tissues, particularly those with fibers oriented off-axis from the applied load, is not well understood. Therefore, the objective of this study was to investigate the effectiveness of mid-length notch geometries in producing repeatable and consistent tissue failure within the gauge region of AF mechanical test specimens...
September 8, 2017: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/28885652/vascularised-and-modified-lower-leg-rotationplasty-for-the-treatment-of-severe-infection-and-bone-loss-of-the-proximal-femur-a-case-report
#14
Sebastian Fischer, Christoph Hirche, Volkmar G Heppert, Paul A Grützner, Ulrich Kneser, Thomas Kremer
CASE DESCRIPTION: We report a reconstructive case in a paraplegic patient, who suffers from a severe proximal femur infection. Aiming at the preservation of the capacity to remain in a seated position to operate a wheelchair, lower leg rotationplasty was considered suitable for reconstruction. Due to severe infection and subclinical femoral artery stenosis, rotationplasty was supercharged by the inferior epigastric artery. Furthermore, extensor tendons of the foot were attached to the acetabulum to facilitate stability of the neo-hip joint...
September 2, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/28880464/dual-growth-factor-immobilized-asymmetrically-porous-membrane-for-bone-to-tendon-interface-regeneration-on-rat-patellar-tendon-avulsion-model
#15
Joong-Hyun Kim, Se Heang Oh, Hyun Ki Min, Jin Ho Lee
Insufficient repair of the bone-to-tendon interface (BTI) with structural/compositional gradients has been a significant challenge in orthopedics. In this study, dual growth factor [platelet-derived growth factor-BB (PDGF-BB) and bone morphogenetic protein-2 (BMP-2)]-immobilized polycaprolactone (PCL)/Pluronic F127 asymmetrically porous membrane was fabricated to estimate its feasibility as a potential strategy for effective regeneration of BTI injury. The growth factors immobilized (via heparin-intermediated interactions) on the membrane were continuously released for up to ∼80% of the initial loading amount after 5 weeks without a significant initial burst...
September 7, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28878530/oldest-epiphyseal-osteochondroma-in-a-subadult-from-ancient-egypt
#16
Albert Isidro, Josep Maria Catalán, Carme Prat, Ferran Torner
Benign bone tumours are pathologies frequently encountered in archaeological human remains, with the most common being osteoma and osteochondroma. We present the case of a juvenile individual recovered from the Necropolis of Sharuna, Middle Egypt and dated to the end of Old Kingdom and First Intermediate Period of Ancient Egypt (circa 2150 BC), showing an osteochondroma arising from the proximal epiphysis of the right tibia which, in all likelihood, affected the patellar tendon in life. Osteochondromas are usually discovered during childhood and adolescence...
August 2017: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/28877329/comparison-of-knee-stability-and-synovial-fluid-alterations-in-anterior-cruciate-ligament-reconstruction-with-a-hamstring-autograft-or-an-allograft
#17
Rui Yang, Haiquan Deng, Jingyi Hou, Yi Ouyang, Zhong Chen, Bin Song, Yunfeng Zhou, Weiquan Tan, Weiping Li, Huiyong Shen
This study compared knee stability and alterations in the composition of synovial fluid among patients who underwent arthroscopic anterior cruciate ligament (ACL) reconstruction with either a hamstring autograft or a hamstring allograft. This prospective cohort study enrolled 175 patients. Of these patients, 90 underwent hamstring tendon autograft ACL reconstruction. The remaining patients (n=85) underwent hamstring tendon allograft ACL reconstruction. All of the patients had a minimum of 1 year of follow-up (mean, 2...
September 6, 2017: Orthopedics
https://www.readbyqxmd.com/read/28875360/-recurrent-instability-and-instability-arthropathy
#18
REVIEW
L Lacheta, S Siebenlist, A B Imhoff, L Willinger
Capsulolabral reconstruction (Bankart repair) is recommended as the first line treatment in young and functionally demanding active patients with anteroinferior shoulder instability, due to the high tendency to recurrent dislocation. This has become established both for arthroscopic and open primary shoulder stabilization with good clinical outcome; nevertheless, recurrence of dislocation is reported in up to 25% of patients. Risk factors for failed surgery are patient (e.g. young age, male gender and contact sports) and surgery (e...
September 5, 2017: Der Unfallchirurg
https://www.readbyqxmd.com/read/28872895/hyaluronic-acid-accelerates-tendon-to-bone-healing-after-rotator-cuff-repair
#19
Hirokazu Honda, Masafumi Gotoh, Tomonoshin Kanazawa, Hiroki Ohzono, Hidehiro Nakamura, Keisuke Ohta, Kei-Ichiro Nakamura, Kanji Fukuda, Takeshi Teramura, Takashi Hashimoto, Shigeki Shichijo, Naoto Shiba
BACKGROUND: There is growing evidence that the subacromial injection of hyaluronic acid (HA) is effective for pain relief in rotator cuff tears; however, its effect on tendon-to-bone healing remains unknown. PURPOSE: To examine the effect of HA on the chondrogenesis of mesenchymal stem cells (MSCs) in vitro and on tendon-to-bone healing in a rotator cuff repair model. STUDY DESIGN: Controlled laboratory study. METHODS: Bilateral complete tears of the infraspinatus tendon were made in rabbits and subsequently repaired...
September 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28869071/role-of-transplanted-bone-marrow-cells-in-development-of-rotator-cuff-muscle-fatty-degeneration-in-mice
#20
Lawrence V Klomps, Naseem Zomorodi, H Mike Kim
BACKGROUND: Rotator cuff muscle fatty degeneration after a chronic tendon tear is an irreversible pathologic change associated with poor clinical outcomes of tendon repair, and its exact pathogenesis remains unknown. We sought to investigate the role of transplanted bone marrow cells in the development of fatty degeneration, specifically in adipocyte accumulation, using a mouse model. METHODS: Fourteen mice were divided into 2 bone marrow chimeric animal groups: bone marrow transplantation (BMT) group and reverse BMT group...
August 28, 2017: Journal of Shoulder and Elbow Surgery
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