Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#21
JOURNAL ARTICLE
Wonho Jung, Sung-Hyun Yun, Yong-Hwa Park
Condition based maintenance (CBM) has become a very important issue in the industry because it can decrease the inventory as the need of parts can be planned by the identification of a potential failure. However, in order to predict the life span of the ball bearing, it is necessary to acquire data according to the all life span of the bearing. This article presents the time-series dataset, including vibration, and temperature, of the ball bearing under run-to-failure. Through the accelerated life test, the ball bearing was failed at 128 working hours, and the vibration and temperature data for the all running section were included...
June 2024: Data in Brief
#22
JOURNAL ARTICLE
Eziafa I Oduah, Susan T Sharfstein, Nagashree Seetharamu, Steven R Grossman, Larisa Litovchick
Lung cancer is the leading cause of cancer mortality. Despite therapeutic advances in recent years, new treatment strategies are needed to improve outcomes of lung cancer patients. Mutant p53 is prevalent in lung cancers and drives several hallmarks of cancer through a gain-of-function oncogenic program, and often predicts a poorer prognosis. The oncogenicity of mutant p53 is related to its stability and accumulation in cells by evading degradation by the proteasome. Therefore, destabilization of mutant p53 has been sought as a therapeutic strategy, but so far without clinical success...
2024: Frontiers in Oncology
#23
Iosif Lazaridis, Nick Patterson, David Anthony, Leonid Vyazov, Romain Fournier, Harald Ringbauer, Iñigo Olalde, Alexander A Khokhlov, Egor P Kitov, Natalia I Shishlina, Sorin C Ailincăi, Danila S Agapov, Sergey A Agapov, Elena Batieva, Baitanayev Bauyrzhan, Zsolt Bereczki, Alexandra Buzhilova, Piya Changmai, Andrey A Chizhevsky, Ion Ciobanu, Mihai Constantinescu, Marietta Csányi, János Dani, Peter K Dashkovskiy, Sándor Évinger, Anatoly Faifert, Pavel N Flegontov, Alin Frînculeasa, Mădălina N Frînculeasa, Tamás Hajdu, Tom Higham, Paweł Jarosz, Pavol Jelínek, Valeri I Khartanovich, Eduard N Kirginekov, Viktória Kiss, Alexandera Kitova, Alexeiy V Kiyashko, Jovan Koledin, Arkady Korolev, Pavel Kosintsev, Gabriella Kulcsár, Pavel Kuznetsov, Rabadan Magomedov, Mamedov Aslan Malikovich, Eszter Melis, Vyacheslav Moiseyev, Erika Molnár, Janet Monge, Octav Negrea, Nadezhda A Nikolaeva, Mario Novak, Maria Ochir-Goryaeva, György Pálfi, Sergiu Popovici, Marina P Rykun, Tatyana M Savenkova, Vladimir P Semibratov, Nikolai N Seregin, Alena Šefčáková, Mussayeva Raikhan Serikovna, Irina Shingiray, Vladimir N Shirokov, Angela Simalcsik, Kendra Sirak, Konstantin N Solodovnikov, Judit Tárnoki, Alexey A Tishkin, Viktov Trifonov, Sergey Vasilyev, Ali Akbari, Esther S Brielle, Kim Callan, Francesca Candilio, Olivia Cheronet, Elizabeth Curtis, Olga Flegontova, Lora Iliev, Aisling Kearns, Denise Keating, Ann Marie Lawson, Matthew Mah, Adam Micco, Megan Michel, Jonas Oppenheimer, Lijun Qiu, J Noah Workman, Fatma Zalzala, Anna Szécsényi-Nagy, Pier Francesco Palamara, Swapan Mallick, Nadin Rohland, Ron Pinhasi, David Reich
The Yamnaya archaeological complex appeared around 3300BCE across the steppes north of the Black and Caspian Seas, and by 3000BCE reached its maximal extent from Hungary in the west to Kazakhstan in the east. To localize the ancestral and geographical origins of the Yamnaya among the diverse Eneolithic people that preceded them, we studied ancient DNA data from 428 individuals of which 299 are reported for the first time, demonstrating three previously unknown Eneolithic genetic clines. First, a "Caucasus-Lower Volga" (CLV) Cline suffused with Caucasus hunter-gatherer (CHG) ancestry extended between a Caucasus Neolithic southern end in Neolithic Armenia, and a steppe northern end in Berezhnovka in the Lower Volga...
April 18, 2024: bioRxiv
#24
Roberta Faccio, Seunghyun Lee, Biancamaria Ricci, Jennifer Tran, Jiayu Ye, David Clever, Emily Eul, Julia Wang, Pamela Wong, Cynthia Ma, Todd Fehniger
Breast cancer is poorly immunogenic, hence able to evade T cell recognition and respond poorly to immune checkpoint blockade. Breast cancer cells can also evade NK cell-mediated immune surveillance, but the mechanism remains enigmatic. Dickkopf-1 (DKK1) is a Wnt/b-catenin inhibitor, whose levels are increased in breast cancer patients and correlate with reduced overall survival. DKK1 is expressed by cancer-associated fibroblasts (CAFs) in orthotopic breast tumors and patient samples, and at higher levels by bone cells...
April 8, 2024: Research Square
#25
Prajyot Ankar, Pratik Phansopkar
This case report describes the rehabilitation of a 54-year-old female patient with a left knee dislocation and multiligament injury after surgery. The patient experienced persistent pain and difficulty with weight-bearing, leading to the need for surgical repair. The rehabilitation protocol included three phases: pain management, range-of-motion (ROM) restoration, muscle strength improvement, proprioception, and equilibrium promotion. Modalities like cryotherapy, compression, manual therapy, and a tailored exercise regimen were used...
March 2024: Curēus
#26
JOURNAL ARTICLE
Katarina Virijević, Marko N Živanović, Dalibor Nikolić, Nevena Milivojević, Jelena Pavić, Ivana Morić, Lidija Šenerović, Luka Dragačević, Philipp J Thurner, Manuel Rufin, Orestis G Andriotis, Biljana Ljujić, Marina Miletić Kovačević, Miloš Papić, Nenad Filipović
Here, an artificial intelligence (AI)-based approach was employed to optimize the production of electrospun scaffolds for in vivo wound healing applications. By combining polycaprolactone (PCL) and poly(ethylene glycol) (PEG) in various concentration ratios, dissolved in chloroform (CHCl3 ) and dimethylformamide (DMF), 125 different polymer combinations were created. From these polymer combinations, electrospun nanofiber meshes were produced and characterized structurally and mechanically via microscopic techniques, including chemical composition and fiber diameter determination...
April 25, 2024: ACS Applied Materials & Interfaces
#27
REVIEW
Aditya Manoharan, Andrew Fithian, Virginia Xie, Kurt Hartman, William Schairer, Najeeb Khan
Anterior cruciate ligament (ACL) tears are one of the most common orthopedic injuries among athletes. Although a small proportion of patients with isolated tears can return to sports after completing a nonsurgical rehabilitation program, ACL reconstruction is frequently recommended for young athletes, especially those with concomitant knee injuries or symptomatic knee instability. Alongside emerging evidence for the effect of prehabilitation, the current standard of care for postoperative ACL physical therapy includes pain control, range of motion, quadriceps strengthening, weight bearing, postoperative bracing, and dynamic limb stabilization and control...
April 25, 2024: Permanente Journal
#28
JOURNAL ARTICLE
Kimberly H Khoo, Joshua S Yoon, Joseph A Carrese, Sheera F Lerman, C Scott Hultman, Julie A Caffrey
Home oxygen therapy (HOT) is prescribed to patients with pulmonary dysfunction to improve survival and quality of life. However, ignition of oxygen can lead to burns with significant morbidity and mortality. Providers who routinely treat this patient population face an ethical issue: balancing the obligation to provide beneficial treatment to a patient with the responsibility to protect that patient from suffering avoidable burn injuries. A thorough review was conducted to assess the literature regarding ethical considerations involved in managing patients who have been burned while smoking on HOT and who continue to smoke...
April 25, 2024: Journal of Burn Care & Research: Official Publication of the American Burn Association
#29
JOURNAL ARTICLE
Jinxin Xie, Ziyu Zhao, Victoria S Coker, Brian O'Driscoll, Rongsheng Cai, Sarah J Haigh, Stuart M Holmes, Jonathan R Lloyd
BACKGROUND: Biogeochemical processing of metals including the fabrication of novel nanomaterials from metal contaminated waste streams by microbial cells is an area of intense interest in the environmental sciences. RESULTS: Here we focus on the fate of Ce during the microbial reduction of a suite of Ce-bearing ferrihydrites with between 0.2 and 4.2 mol% Ce. Cerium K-edge X-ray absorption near edge structure (XANES) analyses showed that trivalent and tetravalent cerium co-existed, with a higher proportion of tetravalent cerium observed with increasing Ce-bearing of the ferrihydrite...
April 24, 2024: Journal of Nanobiotechnology
#30
JOURNAL ARTICLE
Jing Yang, Wei Xiong, Lin Huang, Zongheng Li, Qingdeng Fan, Fang Hu, Xiaopin Duan, Junbing Fan, Bo Li, Jie Feng, Yikai Xu, Xiaoyuan Chen, Zheyu Shen
As a famous drug delivery system (DDS), mesoporous organosilica nanoparticles (MON) are degraded slowly in vivo and the degraded components are not useful for cell nutrition or cancer theranostics, and superparamagnetic iron oxide nanoparticles (SPION) are not mesoporous with low drug loading content (DLC). To overcome the problems of MON and SPION, we developed mesoporous SPIONs (MSPIONs) with an average diameter of 70 nm and pore size of 3.9 nm. Sorafenib (SFN) and/or brequinar (BQR) were loaded into the mesopores of MSPION, generating SFN@MSPION, BQR@MSPION and SFN/BQR@MSPION with high DLC of 11...
April 24, 2024: Journal of Nanobiotechnology
#31
JOURNAL ARTICLE
Yutao Feng, Yuan Li, Fen Ma, Enjiang Wu, Zewei Cheng, Shiling Zhou, Zhengtao Wang, Li Yang, Xun Sun, Jiwei Zhang
The management of colorectal cancer (CRC) poses a significant challenge, necessitating the development of innovative and effective therapeutics. Our research has shown that notoginsenoside Ft1 (Ng-Ft1), a small molecule, markedly inhibits subcutaneous tumor formation in CRC and enhances the proportion of CD8+ T cells in tumor-bearing mice, thus restraining tumor growth. Investigation into the mechanism revealed that Ng-Ft1 selectively targets the deubiquitination enzyme USP9X, undermining its role in shielding β-catenin...
April 2024: Chinese Journal of Natural Medicines
#32
JOURNAL ARTICLE
Miranda E Schene, Daniel T Infield, Christopher A Ahern
The site-specific encoding of noncanonical amino acids allows for the introduction of rationalized chemistry into a target protein. Of the methods that enable this technology, evolved tRNA and synthetase pairs offer the potential for expanded protein production and purification. Such an approach combines the versatility of solid-phase peptide synthesis with the scalable features of recombinant protein production. We describe the large scale production and purification of eukaryotic proteins bearing fluorinated phenylalanine in mammalian suspension cell preparations...
2024: Methods in Enzymology
#33
JOURNAL ARTICLE
Takuya Tada, Thomas D Norton, Rebecca Leibowitz, Nathaniel R Landau
BACKGROUND: While immunotherapy has been highly successful for the treatment of some cancers, for others, the immune response to tumor antigens is weak leading to treatment failure. The resistance of tumors to checkpoint inhibitor therapy may be caused by T cell exhaustion resulting from checkpoint activation. METHODS: In this study, lentiviral vectors that expressed T cell epitopes of an experimentally introduced tumor antigen, ovalbumin, or the endogenous tumor antigen, Trp1 were developed...
April 24, 2024: Journal for Immunotherapy of Cancer
#34
JOURNAL ARTICLE
Jason K Cullen, Pei-Yi Yap, Blake Ferguson, Zara C Bruce, Motoko Koyama, Herlina Handoko, Kevin Hendrawan, Jacinta L Simmons, Kelly M Brooks, Jenny Johns, Emily S Wilson, Marjorie M A de Souza, Natasa Broit, Praphaporn Stewart, Daniel Shelley, Tracey McMahon, Steven M Ogbourne, Tam Hong Nguyen, Yi Chieh Lim, Alberto Pagani, Giovanni Appendino, Victoria A Gordon, Paul W Reddell, Glen M Boyle, Peter G Parsons
BACKGROUND: Tigilanol tiglate (TT) is a protein kinase C (PKC)/C1 domain activator currently being developed as an intralesional agent for the treatment of various (sub)cutaneous malignancies. Previous work has shown that intratumoral (I.T.) injection of TT causes vascular disruption with concomitant tumor ablation in several preclinical models of cancer, in addition to various (sub)cutaneous tumors presenting in the veterinary clinic. TT has completed Phase I dose escalation trials, with some patients showing signs of abscopal effects...
April 24, 2024: Journal for Immunotherapy of Cancer
#35
JOURNAL ARTICLE
Jaabir D Ali, Adriana Guatame-Garcia, Heather E Jamieson, Michael B Parsons, Matthew I Leybourne, Iris Koch, Kela P Weber, David J Patch, Anna L Harrison, Bas Vriens
We studied the occurrence of dissolved thiolated Arsenic (As) in legacy tailings systems in Ontario and Nova Scotia, Canada, and used aqueous and mineralogical speciation analyses to assess its governing geochemical controls. Surface-accessible and inundated tailings in Cobalt, Ontario, contained ~1 wt-% As mainly hosted in secondary arsenate minerals (erythrite, yukonite, and others) and traces of primary sulfide minerals (cobaltite, gersdorffite and others). Significant fractions of thiolated As (up to 5...
April 22, 2024: Science of the Total Environment
#36
EDITORIAL
Matthew F Hudson
No abstract text is available yet for this article.
February 29, 2024: JNCI Cancer Spectrum
#37
JOURNAL ARTICLE
Gonçalo Gamito, Carlos Jp Monteiro, Maria Celeste Dias, Helena Oliveira, Artur Ms Silva, Maria A F Faustino, Sónia Silva
Iron-magnetic nanoparticles (Fe-NMPs) are widely used in environmental remediation, while porphyrin-based hybrid materials anchored to silica-coated Fe3 O4 -nanoparticles (Fe3 O4 -NPs) have been used for water disinfection purposes. To assess their safety on plants, especially concerning potential environmental release, it was investigated for the first time, the impact on plants of a silica-coated Fe3 O4 -NPs bearing a porphyrinic formulation (FORM) - FORM@NMP. Additionally, FORM alone and the magnetic nanoparticles without FORM anchored (NH2 @NMP) were used for comparison...
April 12, 2024: Journal of Hazardous Materials
#38
JOURNAL ARTICLE
Lauren Manley, Lenna Nepomnyaschy
BACKGROUND: Half of US women will experience intimate partner violence (IPV), and nearly all children in families experiencing such violence will be exposed. The negative effects of IPV exposure on children's mental and physical health are well-documented; however, less is known about effects on children's sleep health, a key marker of well-being. OBJECTIVE: This study examines the associations of early childhood exposure to maternal experiences of IPV with sleep health in adolescence, focusing on multiple dimensions of sleep health and differences by child sex...
April 23, 2024: Child Abuse & Neglect
#39
JOURNAL ARTICLE
Pingping Li, Yongkun Li, Xuesong Ma, Liangping Li, Shulan Zeng, Yan Peng, Hong Liang, Guohai Zhang
Targeting polo-box domain (PBD) small molecule for polo-like kinase 1 (PLK1) inhibition is a viable alternative to target kinase domain (KD), which could avoid pan-selectivity and dose-limiting toxicity of ATP-competitive inhibitors. However, their efficacy in these settings is still low and inaccessible to clinical requirement. Herein, we utilized a structure-based high-throughput virtual screen to find novel chemical scaffold capable of inhibiting PLK1 via targeting PBD and identified an initial hit molecule compound 1a...
April 20, 2024: European Journal of Medicinal Chemistry
#40
JOURNAL ARTICLE
Manjiao Chen, Wang Guo, Xinjun Hu, Jianping Tian
Scorodites are commonly used for arsenic immobilization, and it is also the main component of arsenic bearing tailings. Alkali-activated geopolymers are commonly used to landfill arsenic-bearing minerals. However, there no previous studies have explored the interaction between geopolymer molecules and the surface of scorodite. In this paper, Si(OH)4 as a monomer molecule of geopolymer, the mechanism of adsorption and 'ion exchange' between Si(OH)4 molecule and the surface of scorodite during alkali-activation is studied...
April 22, 2024: Journal of Molecular Graphics & Modelling
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
