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https://www.readbyqxmd.com/read/29245126/geographic-and-social-disparities-in-exposure-to-air-neurotoxicants-at-u-s-public-schools
#1
Sara E Grineski, Timothy W Collins
Children are especially vulnerable to the health and developmental impacts of environmental hazards and they spend significant portions of their days at school. Yet there are no national-level studies examining school-level environmental inequalities and few have examined disparate exposure to neurological air toxicants, even though chronic exposure to air pollution impacts children's brain functioning. We paired information about the geographic locations and demographics of each public school in the US with air neurotoxicant exposure estimates pertaining to 24 known neurotoxicants included in the US Environmental Protection Agency's National Air Toxics Assessment...
December 12, 2017: Environmental Research
https://www.readbyqxmd.com/read/29245106/cerebral-arterio-venous-malformations-in-the-paediatric-population-angiographic-characteristics-multimodal-treatment-strategies-and-outcome
#2
Klaus-Peter Stein, Bernd-Otto Huetter, Sophia Goericke, Neriman Oezkan, Rebecca Leyrer, I Erol Sandalcioglu, Michael Forsting, Ulrich Sure, Oliver Mueller
OBJECTIVES: Cerebral arterio-venous malformations (AVM) are considered congenital lesions, emerging as an important cause of haemorrhagic stroke in children. The potential influence of age on clinical presentation and angio-architecture have been analysed extensively in the last years. Yet, comparative studies comprising ascending age groups may be limited in their conclusions, especially when comparing young children and adults. It is the aim of this study to evaluate characteristic clinical and angiographic features of AVM within a paediatric subgroup and their correlation to age at presentation...
December 5, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29244848/surface-modified-nanoparticles-as-anti-biofilm-filler-for-dental-polymers
#3
Nathan Zaltsman, Andrei C Ionescu, Ervin I Weiss, Eugenio Brambilla, Shaul Beyth, Nurit Beyth
The objective of the study was to synthesis silica nanoparticles modified with (i) a tertiary amine bearing two t-cinnamaldehyde substituents or (ii) dimethyl-octyl ammonium, alongside the well-studied quaternary ammonium polyethyleneimine nanoparticles. These were to be evaluated for their chemical and mechanical properties, as well for antibacterial and antibiofilm activity. Samples were incorporated in commercial dental resin material and the degree of monomer conversion, mechanical strength, and water contact angle were tested to characterize the effect of the nanoparticles on resin material...
2017: PloS One
https://www.readbyqxmd.com/read/29244835/tumor-suppressor-protein-p53-mediated-repression-of-human-mitotic-centromere-associated-kinesin-gene-expression-is-exerted-via-down-regulation-of-sp1-level
#4
Do Youn Jun, Ji Young Lee, Hae Sun Park, Yun Han Lee, Young Ho Kim
The repressive role of p53 on the human mitotic centromere-associated kinesin (MCAK) core promoter from ‒266 to +54, relative to the transcription start site, has been determined. The MCAK mRNA and protein levels were 2.1- and 3.0-fold higher, respectively, in HCT116 (p53‒/‒) than in HCT116 (p53+/+) cells. Enforced down-regulation of p53 levels either in HCT116 (p53+/+) cells by p53 RNAi treatment or in MCF-7 cells using shRNA for p53 (shp53) resulted in a remarkable increase in the MCAK protein level...
2017: PloS One
https://www.readbyqxmd.com/read/29244831/antimicrobial-susceptibility-and-molecular-epidemiology-of-clinical-enterobacter-cloacae-bloodstream-isolates-in-shanghai-china
#5
Su Wang, Shu-Zhen Xiao, Fei-Fei Gu, Jin Tang, Xiao-Kui Guo, Yu-Xing Ni, Jie-Ming Qu, Li-Zhong Han
BACKGROUND: Enterobacter cloacae is a major nosocomial pathogen causing bloodstream infections. We retrospectively conducted a study to assess antimicrobial susceptibility and phylogenetic relationships of E. cloacae bloodstream isolates in two tertiary university-affiliated hospitals in Shanghai, in order to facilitate managements of E. cloacae bloodstream infections and highlight some unknowns for future prevention. METHODS: Fifty-three non-duplicate E. cloacae bloodstream isolates were consecutively collected from 2013 to 2016...
2017: PloS One
https://www.readbyqxmd.com/read/29244775/spatial-temporal-and-dietary-variables-associated-with-elevated-mercury-exposure-in-peruvian-riverine-communities-upstream-and-downstream-of-artisanal-and-small-scale-gold-mining
#6
Lauren Wyatt, Ernesto J Ortiz, Beth Feingold, Axel Berky, Sarah Diringer, Ana Maria Morales, Elvis Rojas Jurado, Heileen Hsu-Kim, William Pan
Artisanal and small-scale gold mining (ASGM) is a primary contributor to global mercury and its rapid expansion raises concern for human exposure. Non-occupational exposure risks are presumed to be strongly tied to environmental contamination; however, the relationship between environmental and human mercury exposure, how exposure has changed over time, and risk factors beyond fish consumption are not well understood in ASGM settings. In Peruvian riverine communities (n = 12), where ASGM has increased 4-6 fold over the past decade, we provide a large-scale assessment of the connection between environmental and human mercury exposure by comparing total mercury contents in human hair (2-cm segment, n = 231) to locally caught fish tissue, analyzing temporal exposure in women of child bearing age (WCBA, 15-49 years, n = 46) over one year, and evaluating general mercury exposure risks including fish and non-fish dietary items through household surveys and linear mixed models...
December 15, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29244724/rlj-rgd3-suppresses-the-growth-of-heya8-cells-in-nude-mice
#7
Yuanyuan Zheng, Li Lv, Longda Yi, Rui Wu, Rong Xiao, Jihong Wang
In the previous study, rLj-RGD3, a recombinant toxin protein which contains three RGD motifs, was reported to not only inhibit the proliferation of an ovarian cancer cell line, HeyA8 cells, by inducing apoptosis, but also block their adhesion, migration and invasion processes. However, whether rLj-RGD3 could also suppress the tumor growth in HeyA8 xenografted mice has not been reported yet. In the present study, rLj-RGD3 was intraperitoneally injected in the nude mice bearing HeyA8 tumors. Compared with the control group (normal saline), rLj-RGD3 inhibited the tumor growth significantly in the HeyA8 xenografted mice in a dose-dependent manner without affecting their body weights...
December 15, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29244672/a-short-femoral-stem-in-revision-total-hip-replacement-an-alternative-solution-for-prosthetic-fracture-a-case-report
#8
Paul Y F Lee, David J Woodnutt, David M Golding
CASE: A 65-year-old farmer re-presented 5 years after sustaining a midshaft prosthetic fracture of a previous long-stem revision hip replacement. He was treated with a proximal-loading short femoral stem, and did not require an extended trochanteric osteotomy for removal of the well-fixed distal implant. He was able to fully bear weight immediately postoperatively, and he remained pain-free without functional loss at the 42-month follow-up. CONCLUSION: This use of a modern short-stem prosthesis is a treatment option for a potentially complex prosthetic fracture in highly active patients, and it reduces intraoperative complexity...
April 2017: JBJS Case Connector
https://www.readbyqxmd.com/read/29244659/intra-articular-patellar-dislocation-a-technique-for-closed-reduction-a-case-report-and-review-of-the-literature
#9
Lachlan Wight, Dugal James
CASE: An 87-year-old man fell onto a flexed knee and sustained a closed intra-articular patellar dislocation. A closed reduction was performed under intravenous sedation by flexing the knee to 90°, applying an anterior drawer force to the tibia, and applying pressure to the inferior pole of the patella. The day after reduction, weight-bearing was begun in a hinged brace set at 0° to 90°. Full function was regained by 6 weeks postreduction. CONCLUSION: Intra-articular patellar dislocation may present as an unusual cause of a locked knee...
December 13, 2017: JBJS Case Connector
https://www.readbyqxmd.com/read/29244485/critical-role-of-trp-588-of-presynaptic-munc13-1-for-ligand-binding-and-membrane-translocation
#10
Joydip Das, Noemi Kedei, Jessica S Kelsey, Youngki You, Satyabrata Pany, Gary A Mitchell, Nancy E Lewin, Peter M Blumberg
Munc13-1 is a presynaptic active-zone protein essential for neurotransmitter release and presynaptic plasticity in the brain. This multi-domain scaffold protein contains a C1 domain that binds to the activator diacylglycerol/phorbol ester. Although the C1 domain bears close structural homology with the C1 domains of protein kinase C (PKC), the tryptophan residue at position 22 (588 in the full-length Munc13-1) occludes the activator binding pocket, which is not the case for PKC. To elucidate the role of this tryptophan, we generated W22A, W22K, W22D, W22Y and W22F substitutions in the full-length Munc13-1, expressed the GFP- tagged constructs in Neuro-2a cells, and measured their membrane translocation in response to phorbol ester treatment by imaging of the live cells using confocal microscopy...
December 15, 2017: Biochemistry
https://www.readbyqxmd.com/read/29244223/fixed-bearing-medial-unicompartmental-knee-arthroplasty-restores-neither-the-medial-pivoting-behavior-nor-the-ligament-forces-of-the-intact-knee-in-passive-flexion
#11
Mohammad Kia, Lucian C Warth, Joseph D Lipman, Timothy M Wright, Geoffrey H Westrich, Michael B Cross, David J Mayman, Andrew D Pearle, Carl W Imhauser
Medial unicompartmental knee arthroplasty (UKA) is an accepted treatment for isolated medial osteoarthritis. However, using an improper thickness for the tibial component may contribute to early failure of the prosthesis or disease progression in the unreplaced lateral compartment. Little is known of the effect of insert thickness on both knee kinematics and ligament forces. Therefore, a computational model of the tibiofemoral joint was used to determine how non-conforming, fixed bearing medial UKA affects tibiofemoral kinematics and tension in the medial collateral ligament (MCL) and the anterior cruciate ligament (ACL) during passive knee flexion...
December 15, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29244160/interplay-between-the-catabolite-repression-control-protein-crc-hfq-and-rna-in-hfq-dependent-translational-regulation-in-pseudomonas-aeruginosa
#12
Elisabeth Sonnleitner, Alexander Wulf, Sébastien Campagne, Xue-Yuan Pei, Michael T Wolfinger, Giada Forlani, Konstantin Prindl, Laetitia Abdou, Armin Resch, Frederic H-T Allain, Ben F Luisi, Henning Urlaub, Udo Bläsi
In Pseudomonas aeruginosa the RNA chaperone Hfq and the catabolite repression control protein (Crc) act as post-transcriptional regulators during carbon catabolite repression (CCR). In this regard Crc is required for full-fledged Hfq-mediated translational repression of catabolic genes. RNAseq based transcriptome analyses revealed a significant overlap between the Crc and Hfq regulons, which in conjunction with genetic data supported a concerted action of both proteins. Biochemical and biophysical approaches further suggest that Crc and Hfq form an assembly in the presence of RNAs containing A-rich motifs, and that Crc interacts with both, Hfq and RNA...
December 13, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29244129/dolutegravir-reshapes-the-genetic-diversity-of-hiv-1-reservoirs
#13
Pierre Gantner, Guinevere Q Lee, David Rey, Thibault Mesplede, Marialuisa Partisani, Christine Cheneau, Geneviève Beck-Wirth, Jean-Pierre Faller, Mahsa Mohseni-Zadeh, Martin Martinot, Mark A Wainberg, Samira Fafi-Kremer
Objectives: Better understanding of the dynamics of HIV reservoirs under ART is a critical step to achieve a functional HIV cure. Our objective was to assess the genetic diversity of archived HIV-1 DNA over 48 weeks in blood cells of individuals starting treatment with a dolutegravir-based regimen. Methods: Eighty blood samples were prospectively and longitudinally collected from 20 individuals (NCT02557997) including: acutely (n = 5) and chronically (n = 5) infected treatment-naive individuals, as well as treatment-experienced individuals who switched to a dolutegravir-based regimen and were either virologically suppressed (n = 5) or had experienced treatment failure (n = 5)...
December 13, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29243885/first-end-deck-cyclo-p4-fe-complex-synthesis-and-reactivity
#14
Anthony Cavaillé, Nathalie Saffon-Merceron, Noel Nebra, Marie Fustier-Boutignon, Nicolas Mézailles
Reduction of the FeII complex [(PhPP2Cy)FeCl2] (2) generates an electron rich and unsaturated Fe0 which is reacted with white phosphorus. The new complex obtained, [(PhPP2Cy)Fe(η4-P4)] (3), is the first iron cyclo-P4 complex and the only known stable end deck cyclo-P4 complex outside of group V. Complex 3 bears a FeII center as shown by Mössbauer spectroscopy, associated to a P42- fragment. Analysis of the molecular orbitals rationalizes the distinct reactivity of complex 3. Reaction of complex 3 with H+ affords the unstable complex [(PhPP2Cy)Fe(η4-P4)(H)]+ (4), whereas with CuCl and BCF the complexes [(PhPP2Cy)Fe(η4:η1-P4)(μ-CuCl)]2 (5) and [(PhPP2Cy)Fe(η4:η1-P4)B(C6F5)3] (6) are formed...
December 15, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29243870/mechanistic-studies-on-nahco3-hydrogenation-and-hcooh-dehydrogenation-reactions-catalysed-by-a-fe-ii-linear-tetraphosphine-complex
#15
Rocio Marcos, Federica Bertini, Zilvinas Rinkevicius, Maurizio Peruzzini, Luca Gonsalvi, Mårten Ahlquist
We present a theoretical extension of the previously published bicarbonate hydrogenation to formate and formic acid dehydrogenation catalysed by Fe(II) complexes bearing the linear tetraphosphine ligand tetraphos-1 The hydrogenation reaction was found to proceed at the singlet surface with two competing pathways: A) H2 association to the Fe-H species followed by deprotonation to give a Fe(H)2 intermediate, which then reacts with CO2 to give formate. B) CO2 insertion into the Fe-H bond, followed by H2 association and subsequent deprotonation...
December 15, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29243365/vitamin-a-coupled-liposome-system-targeting-free-cholesterol-accumulation-in-hepatic-stellate-cells-offers-a-beneficial-therapeutic-strategy-for-liver-fibrosis
#16
Hirotaka Furuhashi, Kengo Tomita, Toshiaki Teratani, Motonori Shimizu, Makoto Nishikawa, Masaaki Higashiyama, Takeshi Takajo, Kazuhiko Shirakabe, Koji Maruta, Yoshikiyo Okada, Chie Kurihara, Chikako Watanabe, Shunsuke Komoto, Suefumi Aosasa, Shigeaki Nagao, Junji Yamamoto, Soichiro Miura, Ryota Hokari
AIM: Liver fibrosis is a life-threatening disorder for which no approved therapy is available. Recently, we reported that mouse hepatic stellate cell (HSC) activation increased free cholesterol (FC) accumulation partly by enhancing signaling via sterol regulatory element-binding protein 2 (SREBP2) and microRNA-33a (miR-33a), which resulted in HSC sensitization to transforming growth factor-β (TGFβ)-induced activation in a 'vicious cycle' of liver fibrosis. METHODS: Human HSCs were isolated from surgical liver specimens from the control patients and patients with liver fibrosis...
December 15, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29243136/recalibration-of-hand-position-sense-during-unconscious-active-and-passive-movement
#17
Zakaryah Abdulkarim, H Henrik Ehrsson
Precise knowledge of one's limbs' position in space is fundamental for goal-directed action. The brain's representation of the body in space is thought to be generated through a process of multisensory integration of visual, tactile and proprioceptive signals. In this study, we devised a setup that allowed us to displace participants' right hand without their subjective awareness. We accomplished this task by instructing the participants to view a live video feed of their hand from the first-person perspective...
December 14, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/29242872/phenylamino-derivatives-of-tris-2-pyridylmethyl-amine-hydrogen-bonded-peroxodicopper-complexes
#18
E W Dahl, H T Dong, N K Szymczak
A series of copper complexes bearing new 6-substituted tris(2-pyridylmethyl)amine ligands (LR) appended with NH(p-R-C6H4) groups (R = H, CF3, OMe) were prepared. These ligands are electronically tunable (ΔE1/2 = 160 mV) and CuI(LR)+ complexes react with oxygen to form hydrogen bonded (trans-1,2-peroxo)dicopper species.
December 15, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29242820/establishing-a-live-cartilage-on-cartilage-interface-for-tribological-testing
#19
Robert L Trevino, Jonathan Stoia, Michel P Laurent, Carol A Pacione, Susan Chubinskaya, Markus A Wimmer
Mechano-biochemical wear encompasses the tribological interplay between biological and mechanical mechanisms responsible for cartilage wear and degradation. The aim of this study was to develop and start validating a novel tribological testing system, which better resembles the natural joint environment through incorporating a live cartilage-on-cartilage articulating interface, joint specific kinematics, and the application of controlled mechanical stimuli for the measurement of biological responses in order to study the mechano-biochemical wear of cartilage...
March 2017: Biotribology
https://www.readbyqxmd.com/read/29242788/obturator-dislocation-of-hip-with-ipsilateral-fracture-neck-femur-a-case-report
#20
Sumit Kumar Jain, Parit Aggarwal, Arun Yadav
Introduction: Traumatic dislocation of the hip with ipsilateral fracture neck femur is a rare injury because of the different mechanism of both these injuries. The management of such injuries is a challenge as the chances of nonunion and avascular necrosis of femoral head are very high with fixation methods. We report a case of obturator dislocation of the hip with ipsilateral fracture neck of the femur which was treated with uncemented total hip replacement. Case Report: A 32-year-old male sustained obturator dislocation with ipsilateral fracture neck femur following road traffic accident...
September 2017: Journal of Orthopaedic Case Reports
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