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https://www.readbyqxmd.com/read/28532095/antitumor-activity-and-safety-evaluation-of-nanaparticle-based-delivery-of-quercetin-through-intravenous-administration-in-mice
#1
Jian Li, Ming Shi, Baoling Ma, Ruixu Niu, Haizhao Zhang, Li Kun
The present study focused on the inhibition effects and the safety evaluation of the quercetin when it was loaded into the nanoliposomes on cervical cancer in vitro and in vivo. Quercetin loaded nanoliposomes (Que-NLs) were first prepared by thin film hydration method and the characterizations of Que-NLs were measured with TEM and dynamic light scattering (DLS) techniques. Then the anti-cervical cancer efficiencies were evaluated by MTT and U14 tumor-bearing mice models in vitro and in vivo respectively. The body changes, organ index, biochemical criterions and histopathological of livers and kidneys in tumor-bearing mice were further assayed to evaluate the safety of Que-NLs...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532091/design-and-fabrication-of-carbon-fibers-with-needle-like-nano-ha-coating-to-reinforce-granular-nano-ha-composites
#2
Xudong Wang, Xueni Zhao, Li Zhang, Wanying Wang, Jing Zhang, Fuzhen He, Jianjun Yang
Carbon fibers (CFs) with needle-like nano-hydroxyapatite (nHA) coating were first used as reinforcing materials named nHA-CFs to improve the mechanical properties of pure HA. A powder mixture containing nHA-CFs and granular nano-HA (gHA) was directly sintered by hot pressing at appropriate sintering pressure and temperature. A three-phase nHA-CFs/gHA composite was designed, fabricated, and used as an artificial bone. Results show that the bending strengths of the nHA-CFs/gHA composite are approximately 41.1% and 59...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28531989/mechanical-behaviour-of-biodegradable-az31-magnesium-alloy-after-long-term-in-vitro-degradation
#3
Isaiah Adekanmbi, Christopher Z Mosher, Helen H Lu, Mathis Riehle, Haytham Kubba, K Elizabeth Tanner
Biodegradable magnesium alloys including AZ31 are exciting candidates for temporary implants as they eliminate the requirement for surgical removal, yet have higher mechanical properties than degradable polymers. However, the very long term mechanical properties and degradation of these alloys have not been fully characterized. The tensile, bending and corrosion behaviour of biodegradable AZ31 Mg alloy specimens have been investigated for up to 9months in vitro in phosphate buffered saline (PBS). Small AZ31 Mg specimens showed a significant drop in bend yield strength and modulus after 3months in vitro degradation and an average mass loss of 6...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28531984/bioactive-materials-driven-primary-stability-on-titanium-biocomposites
#4
T A Dantas, C S Abreu, M M Costa, G Miranda, F S Silva, N Dourado, J R Gomes
The Ti6Al4V alloy constitutes an alternative choice to the most common metal-polymer solutions for total hip arthroplasty (THA) due to good biocompatibility, optimal mechanical properties and high load bearing capacity. However, as Ti6Al4V is not bioactive in its conventional form, hydroxyapatite (HAp) and tricalcium phosphate (TCP) have been widely used as coatings of metal prostheses due to their osteogenic properties and ability to form strong bonds with bone tissue. A promising approach consists in creating a bioactive surface metal matrix composite Ti6Al4V+β-TCP or Ti6Al4V+HAp, obtained by hot pressing (HP) of powders...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28531916/effects-of-elevated-atmospheric-co2-on-dissolution-of-geological-fluorapatite-in-water-and-soil
#5
Zhen Li, Mu Su, Da Tian, Lingyi Tang, Lin Zhang, Yangfan Zheng, Shuijin Hu
Most of phosphorus (P) is present as insoluble phosphorus-bearing minerals or organic forms in soil. Geological fluorapatite (FAp) is the dominant mineral-weathering source of P. In this study, FAp was added into water and soil under elevated CO2 to investigate the pathway of P release. Two types of soils (an acidic soil from subtropical China and a saline-alkali soil from Tibet Plateau, China) with similar total P content were studied. In the solution, increased CO2 in air enhanced the dissolution of FAp, i...
May 16, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28531811/synthesis-of-novel-indole-derivatives-as-promising-dna-binding-agents-and-evaluation-of-antitumor-and-antitopoisomerase-i-activities
#6
Elizabeth Almeida Lafayette, Sinara Mônica Vitalino de Almeida, Renata Virginia Cavalcanti Santos, Jamerson Ferreira de Oliveira, Cezar Augusto da Cruz Amorim, Rosali Maria Ferreira da Silva, Maira Galdino da Rocha Pitta, Ivan da Rocha Pitta, Ricardo Olimpio de Moura, Luiz Bezerra de Carvalho Júnior, Moacyr Jesus Barreto de Melo Rêgo, Maria do Carmo Alves de Lima
Molecules bearing indole nucleus present diverse biological properties such as antitumor and anti-inflammatory activities that can be associated both to DNA and protein interactions. This study focused on the synthesis of new indole derivatives with thiazolidines and imidazolidine rings condensed as side chains as well as the evaluation of their ability to interact with the DNA and antitumor and topoisomerase inhibition activities. All derivatives were successfully synthesized and their structures were elucidated by mass spectrometry (MS), infrared (IR), spectroscopy (1)H NMR, (13)C NMR, COSY (1)H-(1)H and HSQC (1)H-(13)C...
May 4, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28531205/cost-analysis-of-human-papillomavirus-related-cervical-diseases-and-genital-warts-in-swaziland
#7
Themba G Ginindza, Benn Sartorius, Xolisile Dlamini, Ellinor Östensson
BACKGROUND: Human papillomavirus (HPV) has proven to be the cause of several severe clinical conditions on the cervix, vulva, vagina, anus, oropharynx and penis. Several studies have assessed the costs of cervical lesions, cervical cancer (CC), and genital warts. However, few have been done in Africa and none in Swaziland. Cost analysis is critical in providing useful information for economic evaluations to guide policymakers concerned with the allocation of resources in order to reduce the disease burden...
2017: PloS One
https://www.readbyqxmd.com/read/28531204/messinian-age-and-savannah-environment-of-the-possible-hominin-graecopithecus-from-europe
#8
Madelaine Böhme, Nikolai Spassov, Martin Ebner, Denis Geraads, Latinka Hristova, Uwe Kirscher, Sabine Kötter, Ulf Linnemann, Jérôme Prieto, Socrates Roussiakis, George Theodorou, Gregor Uhlig, Michael Winklhofer
Dating fossil hominids and reconstructing their environments is critically important for understanding human evolution. Here we date the potentially oldest hominin, Graecopithecus freybergi from Europe and constrain the environmental conditions under which it thrived. For the Graecopithecus-bearing Pikermi Formation of Attica/Greece, a saline aeolian dust deposit of North African (Sahara) provenance, we obtain an age of 7.37-7.11 Ma, which is coeval with a dramatic cooling in the Mediterranean region at the Tortonian-Messinian transition...
2017: PloS One
https://www.readbyqxmd.com/read/28530799/bioinspired-interface-engineering-for-moisture-resistance-in-nacre-mimetic-cellulose-nanofibrils-clay-nanocomposites
#9
Kun Yao, Shu Huang, Hu Tang, Yeping Xu, Gerd Buntkowsky, Lars A Berglund, Qi Zhou
The interfacial adhesion design between "mortar" and "bricks" is essential for mechanical and barrier performance of nanocellulose-based nacre-mimetic nanocomposites, especially at high moisture conditions. To address this fundamental challenge, dopamine (DA) has been conjugated to cellulose nanofibrils (CNFs) and subsequently assembled with montmorillonite (MTM) to generate layered nanocomposite films inspired by the strong adhesion of mussel adhesive proteins to inorganic surfaces under water. The selective formation of catechol/metal ion chelation and hydrogen bonding at the interface between MTM platelets and CNFs bearing DA renders transparent films with strong mechanical properties, particularly at high humidity and in wet state...
May 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28530795/modelling-living-cells-response-to-surface-tension-and-chemical-patterns
#10
Marco Macis, Francesca Lugli, Francesco Zerbetto
Mechanobiology is an important epigenetic factor. It influences cell functioning and bears on gene induction, protein synthesis, cell growth and differentiation. In the presence of patterned chemical cues, living cells can take shapes that are far from that of a drop of fluid. These shapes are characterized by inward curvatures that are pinned at the points of location of the cues. The mechano-chemical interactions that orchestrate cell behavior is simulated and controlled by modeling the cells as made by parcels of fluid...
May 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28530662/pd-l1-inhibits-acute-and-chronic-pain-by-suppressing-nociceptive-neuron-activity-via-pd-1
#11
Gang Chen, Yong Ho Kim, Hui Li, Hao Luo, Da-Lu Liu, Zhi-Jun Zhang, Mark Lay, Wonseok Chang, Yu-Qiu Zhang, Ru-Rong Ji
Programmed cell death ligand-1 (PD-L1) is typically produced by cancer cells and suppresses immunity through the receptor PD-1 expressed on T cells. However, the role of PD-L1 and PD-1 in regulating pain and neuronal function is unclear. Here we report that both melanoma and normal neural tissues including dorsal root ganglion (DRG) produce PD-L1 that can potently inhibit acute and chronic pain. Intraplantar injection of PD-L1 evoked analgesia in naive mice via PD-1, whereas PD-L1 neutralization or PD-1 blockade induced mechanical allodynia...
May 22, 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/28530551/angular-velocity-integration-in-a-fly-heading-circuit
#12
Daniel Turner-Evans, Stephanie Wegener, Hervé Rouault, Romain Franconville, Tanya Wolff, Johannes D Seelig, Shaul Druckmann, Vivek Jayaraman
Many animals maintain an internal representation of their heading as they move through their surroundings. Such a compass representation was recently discovered in a neural population in the Drosophila melanogaster central complex, a brain region implicated in spatial navigation. Here, we use two-photon calcium imaging and electrophysiology in head-fixed walking flies to identify a different neural population that conjunctively encodes heading and angular velocity, and is excited selectively by turns in either the clockwise or counterclockwise direction...
May 22, 2017: ELife
https://www.readbyqxmd.com/read/28530407/a-gadolinium-complex-of-1-4-7-10-tetraazacyclododecane-1-4-7-trisacetic-acid-do3a-ethoxybenzyl-eob-conjugate-as-a-new-macrocyclic-hepatobiliary-mri-contrast-agent
#13
Ah Rum Baek, Hee-Kyung Kim, Subin Park, Gang Ho Lee, Hyo Jeung Kang, Jae Chang Jung, Joon-Suk Park, Hun-Kyu Ryeom, Tae-Jeong Kim, Yongmin Chang
We report the synthesis of a macrocyclic Gd chelate based on a 1,4,7,10-tetraazacyclododecane-1,4,7-trisacetic acid (DO3A) coordination cage bearing an ethoxybenzyl (EOB) moiety and discuss its use as a T1 hepatobiliary magnetic resonance imaging (MRI) contrast agent. The new macrocyclic liver agent shows high chelation stability and high r1 relaxivity compared with linear-type Gd chelates, which are the current clinically approved liver agents. Our macrocyclic, liver-specific Gd chelate was evaluated in vivo through biodistribution analysis and liver MRI, which demonstrated its high tumor detection sensitivity and suggested that the new Gd complex is a promising contrast agent for liver cancer imaging...
May 22, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28530247/long-range-ferrimagnetic-order-in-a-two-dimensional-supramolecular-kondo-lattice
#14
Jan Girovsky, Jan Nowakowski, Md Ehesan Ali, Milos Baljozovic, Harald R Rossmann, Thomas Nijs, Elise A Aeby, Sylwia Nowakowska, Dorota Siewert, Gitika Srivastava, Christian Wäckerlin, Jan Dreiser, Silvio Decurtins, Shi-Xia Liu, Peter M Oppeneer, Thomas A Jung, Nirmalya Ballav
Realization of long-range magnetic order in surface-supported two-dimensional systems has been challenging, mainly due to the competition between fundamental magnetic interactions as the short-range Kondo effect and spin-stabilizing magnetic exchange interactions. Spin-bearing molecules on conducting substrates represent a rich platform to investigate the interplay of these fundamental magnetic interactions. Here we demonstrate the direct observation of long-range ferrimagnetic order emerging in a two-dimensional supramolecular Kondo lattice...
May 22, 2017: Nature Communications
https://www.readbyqxmd.com/read/28530098/formal-total-synthesis-of-%C3%A2-lycojaponicumin-c
#15
Nan Zheng, Lijie Zhang, Jianxian Gong, Zhen Yang
The formal total synthesis of (±)-lycojaponicumin C has been accomplished. Key transformations include a Rh-catalyzed formal [3 + 2] cycloaddition reaction to construct the bicyclic [3.3.0] scaffold bearing two vicinal quaternary carbon centers, a stereoselective γ-hydroxyl directed Michael addition to introduce the vinyl group at a bulky position, and a late-stage ring-closing metathesis reaction to form the cyclohexanone ring.
May 22, 2017: Organic Letters
https://www.readbyqxmd.com/read/28529879/beyond-the-raccoon-roundworm-the-natural-history-of-non-raccoon-baylisascaris-species-in-the-new-world
#16
REVIEW
Sarah G H Sapp, Pooja Gupta, Melissa K Martin, Maureen H Murray, Kevin D Niedringhaus, Madeleine A Pfaff, Michael J Yabsley
A total of 10 species of Baylisascaris, a genus of ascaridoid nematodes, occur worldwide and 6 of them occur in the New World. Most of the Baylisascaris species have a similar life cycle with carnivorous mammals or marsupials serving as definitive hosts and a smaller prey host serving as paratenic (or intermediate) hosts. However, one species in rodents is unique in that it only has one host. Considerable research has been conducted on B. procyonis, the raccoon roundworm, as it is a well-known cause of severe to fatal neurologic disease in humans and many wildlife species...
August 2017: International Journal for Parasitology. Parasites and Wildlife
https://www.readbyqxmd.com/read/28529803/biochemical-content-of-cambium-of-abies-nephrolepis-eaten-by-bears-on-the-far-east-of-russia
#17
I V Seryodkin, A M Zakharenko, P S Dmitrenok, K S Golokhvast
The peculiarity of bears behavior of stripping of bark is typical for all species. We have described the damage to trees, by Asiatic black bear (Ursus thibetanus) and brown bear (U. arctos) in Primorsky Krai and by brown bears on the Sakhalin Island during 1998-2015. In this study, we studied the damaged bark of the tree only in cases where it was clear that part of the cambium was eaten by bears. Cambium of species Abies nephrolepis is the most preferred for bear consumption in Primorsky Krai. We distinguished very large seasonal fluctuations in the amount of its consumption...
2017: Biochemistry Research International
https://www.readbyqxmd.com/read/28529802/r229q-polymorphism-of-nphs2-gene-in-group-of-iraqi-children-with-steroid-resistant-nephrotic-syndrome
#18
Shatha Hussain Ali, Rasha Kasim Mohammed, Hussein Ali Saheb, Ban A Abdulmajeed
Background. The polymorphism R229Q is one of the most commonly reported podocin sequence variations among steroid-resistant nephrotic syndromes (SRNS). Aim of the Study. We investigated the frequency and risk of this polymorphism among a group of Iraqi children with SRNS and steroid-sensitive nephrotic syndrome (SSNS). Patients and Methods. A prospective case control study which was conducted in Al-Imamein Al-Kadhimein Medical City, spanning the period from the 1st of April 2015 to 30th of November 2015. Study sample consisted of 54 children having NS, divided into 2 groups: patients group consisted of 27 children with SRNS, and control group involved 27 children with SSNS...
2017: International Journal of Nephrology
https://www.readbyqxmd.com/read/28529777/crystal-structures-of-titanium-aluminium-and-gallium-complexes-bearing-two-%C3%AE-2-ch3-units
#19
Tim Oswald, Mira Diekmann, Annika Frey, Marc Schmidtmann, Rüdiger Beckhaus
The isotypic crystal structures of two titanocene complexes containing an EMe3 unit (E = Al, Ga; Me = meth-yl) with two μ2-coordinating methyl groups, namely [μ-1(η(5))-(adamantan-1-yl-2κC(1))cycylo-penta-dien-yl]di-μ2-methyl-methyl-2κC-[1(η(5))-penta-methyl-cyclo-penta-dien-yl]aluminiumtitanium(III), [AlTi(CH3)3(C10H15)(C15H18)], and [μ-1(η(5))-(adamantan-1-yl-2κC(1))cycylo-penta-dien-yl]di-μ2-methyl-methyl-2κC-[1(η(5))-penta-methyl-cyclo-penta-dien-yl]galliumtitanium(III), [GaTi(CH3)3(C10H15)(C15H18)], are reported...
May 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/28529647/redox-responsive-hyaluronic-acid-nanogels-for-treating-rhamm-cd168-over-expressive-cancer-both-primary-and-metastatic-tumors
#20
Chenchen Yang, Cheng Li, Peng Zhang, Wei Wu, Xiqun Jiang
It remains a substantial challenge to targetedly deliver drug to both primary tumors and metastatic lesions employing a single nanoparticle delivery system. Here aiming at the receptor for hyaluronic acid mediated motility (RHAMM or CD168), a specific receptor for hyaluronic acid (HA), the bioreductive responsive HA nanogels loaded doxorubicin were prepared. The targeting effects of HA nanogels in high RHAMM-expressed cancer cells, primary and metastatic tumors were investigated. It was found that HA nanogels show a strong in vitro and in vivo RHAMM-mediated cellular uptake and drug delivery...
2017: Theranostics
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