keyword
MENU ▼
Read by QxMD icon Read
search

bear

keyword
https://www.readbyqxmd.com/read/29668017/phylogeographic-analyses-of-the-pampas-cat-leopardus-colocola-carnivora-felidae-reveal-a-complex-demographic-history
#1
Anelisie da Silva Santos, Tatiane Campos Trigo, Tadeu Gomes de Oliveira, Leandro Silveira, Eduardo Eizirik
The pampas cat is a small felid that occurs in open habitats throughout much of South America. Previous studies have revealed intriguing patterns of morphological differentiation and genetic structure among its populations, as well as molecular evidence for hybridization with the closely related L. tigrinus. Here we report phylogeographic analyses encompassing most of its distribution (focusing particularly on Brazilian specimens, which had been poorly sampled in previous studies), using a novel dataset comprising 2,143 bp of the mitogenome, along with previously reported mtDNA sequences...
2018: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/29667824/one-and-two-carbon-homologation-of-primary-and-secondary-alcohols-to-corresponding-carboxylic-esters-using-%C3%AE-carbonyl-bt-sulfones-as-common-intermediate
#2
David J-Y D Bon, Ondřej Kováč, Vendula Ferugová, František Zálešák, Jiri Pospisil
Herein we report the efficient one- and two-carbon homologation of 1° and 2° alcohols to their corresponding homologated esters via the Mitsunobu reaction using β-carbonyl benzothiazole (BT) sulfone intermediates. The one-carbon homologation approach uses standard Mitsunobu C-S bond formation, oxidation and subsequent alkylation, while the two-carbon homologation uses a less common C-C bond forming Mitsunobu reaction. In this latter case, the use of β-BT sulfone bearing esters lowers the pKa sufficiently enough for the substrate to be used as a carbon-based nucleophile and deliver the homologated β-BT sulfone ester, this superfluous sulfone group can then be cleaved...
April 18, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29667819/synthesis-and-evolution-of-a-tna-aptamer-bearing-7-deaza-7-substituted-guanosine-residues
#3
Hui Mei, Jen-Yu Liao, Randi M Jimenez, Yajun Wang, Saikat Bala, Cailen McCloskey, Christopher Switzer, John C Chaput
In vitro selection experiments carried out on artificial genetic polymers require robust and faithful methods for copying genetic information back and forth between DNA and xeno-nucleic acids (XNA). Previously, we have shown that Kod-RI, an engineered polymerase developed to transcribe DNA templates into threose nucleic acid (TNA), can function with high fidelity in the absence of manganese ions. However, the transcriptional efficiency of this enzyme diminishes greatly when individual templates are replaced with libraries of DNA sequences, indicating that manganese ions are still required for in vitro selection...
April 18, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29667752/ion-pairing-assemblies-of-%C3%AF-electronic-anions-formed-by-intramolecular-hydrogen-bonding
#4
Hiromitsu Maeda, Yuka Takeda, Yohei Haketa, Yuta Morimoto, Nobuhiro Yasuda
π-Extended nitro-substituted dipyrrolylphenol derivatives were synthesized, providing π-electronic anions upon deprotonation and stabilization of the phenolate (phenoxide) moiety by the pyrrole NH, which served as a hydrogen-bonding donor. Ion-pairing assemblies of the deprotonated anions were formed in the solid state and as mesophases. In the solid state, the extended π-plane is more suitable to form charge-by-charge assemblies in combination with tetraalkylammonium cations with highly anisotropic orientations through its more efficient stacking...
April 18, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29667747/self-assembled-cyclic-structures-from-copper-ii-peptoids
#5
Totan Ghosh, Natalia Fridman, Monica Kosa, Galia Maayan
Metal-ligand coordination is a key interaction in the self-assembly of biopolymers. Although binding of metal ions to synthetic proteins and peptides is known to yield high-order structures, self-assembly of peptidomimetic molecules upon metal binding is still challenging. Herein we explore the self-assembly of three peptoid trimers 3, 3A and 3B, bearing a bipyridine ligand at their C-terminus, a benzyl group at their N-terminus and a polar group (N-ethyl-R) in the middle position (R = OH, OCH3 and NH2, respectively) by Cu2+ coordination...
April 18, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29667719/occupational-health-hazards-in-the-interventional-laboratory-time-for-a-safer-environment
#6
Lloyd W Klein, Donald L Miller, Stephen Balter, Warren Laskey, Neil Naito, David Haines, Allan Ross, Matthew A Mauro, James A Goldstein
Over the past 30 years, the advent of fluoroscopically guided interventional procedures has resulted in dramatic increments in both X-ray exposure and physical demands that predispose interventionists to distinct occupational health hazards. The hazards of accumulated radiation exposure have been known for years, but until recently the other potential risks have been ill-defined and under-appreciated. The physical stresses inherent in this career choice appear to be associated with a predilection to orthopedic injuries, attributable in great part to the cumulative adverse effects of bearing the weight and design of personal protective apparel worn to reduce radiation risk and to the poor ergonomic design of interventional suites...
January 4, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29667494/discovery-of-a-mcr-1-bearing-plasmid-in-commensal-colistin-resistant-escherichia-coli-from-healthy-broilers-in-faisalabad-pakistan
#7
Jiali Lv, Mashkoor Mohsin, Sheng Lei, Swaminath Srinivas, Raja Talish Wiqar, Jingxia Lin, Youjun Feng
No abstract text is available yet for this article.
April 18, 2018: Virulence
https://www.readbyqxmd.com/read/29667385/chance-of-reimbursement-for-add-on-therapies-in-poland-and-in-the-world-review-of-the-reimbursement-recommendations
#8
Ewa Borowiack, Magdalena Marzec, Anna Nowotarska, Joanna Jarosz, Agata Orkisz, Patrycja Prząda-Machno
INTRODUCTION: Oncology drugs combined with standard therapies (so-called add-on therapies, e.g. bevacizumab, palbociclib) often receive negative recommendations regarding the legitimacy of public financing, issued by government agencies responsible for their assessment, i.e. health technology assessment agencies. The aim of the study was to estimate the scale of the problem related to the reimbursement of add-on therapies used in the treatment of breast and genitourinary cancers in Poland and in the world...
2018: Przegla̧d Epidemiologiczny
https://www.readbyqxmd.com/read/29667369/fully-automated-production-and-characterization-of-64cu-and-proof-of-principle-small-animal-pet-imaging-using-64cu-labelled-ca-xii-targeting-6a10-fab
#9
Luise Fiedler, Markus Kellner, Rosel Oos, Guido Böning, Sibylle Ziegler, Peter Bartenstein, Reinhard Zeidler, Franz Josef Gildehaus, Simon Lindner
64Cu is a cyclotron-produced radionuclide which offers, due to its characteristic decay scheme the possibility to combine PET investigations with radiotherapy. We evaluated the Alceo sys-tem from Comecer SpA to automatically produce 64Cu for radiolabelling purposes. We established a 64Cu production routine with high yields and radionuclide purity in combination with excellent operator radiation protection. The carbonic anhydrase XII targeting 6A10 antibody fab fragment was successfully radiolabelled with the produced 64Cu and proof of principle small animal PET experiments on mice bearing glioma xenografts were performed...
April 18, 2018: ChemMedChem
https://www.readbyqxmd.com/read/29667364/heritability-of-body-size-in-the-polar-bears-of-western-hudson-bay
#10
René M Malenfant, Corey S Davis, Evan S Richardson, Nicholas J Lunn, David W Coltman
Among polar bears (Ursus maritimus), fitness is dependent on body size through males' abilities to win mates, females' abilities to provide for their young, and all bears' abilities to survive increasingly longer fasting periods caused by climate change. In the Western Hudson Bay subpopulation (near Churchill, Manitoba, Canada), polar bears have declined in body size and condition, but nothing is known about the genetic underpinnings of body size variation, which may be subject to natural selection. Here, we combine a 4449-individual pedigree and an array of 5433 single-nucleotide polymorphisms (SNPs) to provide the first quantitative genetics study of polar bears...
April 18, 2018: Molecular Ecology Resources
https://www.readbyqxmd.com/read/29667058/biodegradation-tests-of-mercaptocarboxylic-acids-their-esters-related-divalent-sulfur-compounds-and-mercaptans
#11
Christoph Rücker, Waleed M M Mahmoud, Dirk Schwartz, Klaus Kümmerer
Mercaptocarboxylic acids and their esters, a class of difunctional compounds bearing both a mercapto and a carboxylic acid or ester functional group, are industrial chemicals of potential environmental concern. Biodegradation of such compounds was systematically investigated here, both by literature search and by experiments (Closed Bottle Test OECD 301D and Manometric Respirometry Test OECD 301F). These compounds were found either readily biodegradable or at least biodegradable to a significant extent. Some related compounds of divalent sulfur were tested for comparison (mercaptans, sulfides, disulfides)...
April 17, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29666793/self-assembly-of-a-1-1-ionic-hexagonal-macrocycle-and-its-antiproliferative-activity
#12
Khushwant Singh, Ankit Gangrade, Sourav Bhowmick, Achintya Jana, Biman B Mandal, Neeladri Das
A unique irregular hexagon was self-assembled using an organic donor clip (bearing terminal pyridyl units) and a complementary organometallic acceptor clip. The resulting metallamacrocycle was characterized by multinuclear NMR, mass spectrometry, and elemental analyses. Molecular modeling confirmed hexagonal shaped cavity for this metallamacrocycle which is a unique example of a discrete hexagonal framework self-assembled from only two building blocks. Cytotoxicity of the Pt-based acceptor tecton and the self-assembled PtII -based macrocycle was evaluated using three cancer cell lines and results were compared with cisplatin...
2018: Frontiers in Chemistry
https://www.readbyqxmd.com/read/29666791/supramolecular-organocatalysis-in-water-mediated-by-macrocyclic-compounds
#13
REVIEW
Margherita De Rosa, Pellegrino La Manna, Carmen Talotta, Annunziata Soriente, Carmine Gaeta, Placido Neri
In the last decades many efforts have been devoted to design supramolecular organocatalysts able to work in water as the reaction medium. The use of water as solvent provides promising benefits with respect to environmental impact. In this context, macrocyclic compounds played a role of primary importance thanks to their ease of synthesis and their molecular recognition abilities toward the reactants. The aim of this review is to give an overview of the recent advances in the field of supramolecular organocatalysis in water, focusing the attention on calixarene and cyclodextrins derivatives...
2018: Frontiers in Chemistry
https://www.readbyqxmd.com/read/29666669/-egfr-amplification-induces-sensitivity-to-anti-egfr-therapy-in-pancreatic-acinar-cell-carcinoma
#14
Corentin Richard, Julie Niogret, Romain Boidot, Francois Ghiringhelli
Pancreatic acinar cell carcinoma (PACC) is a rare cancer. When the tumor is metastatic, few therapeutic options are available. Precision medicine using next-generation sequencing is defined by the administration of drugs based on the tumor genetic mutations. The usage of precision medicine for finding new therapeutic options for rare cancers is an emerging field. We have reported here the case of a patient bearing a multitreated metastatic PACC. This patient underwent somatic and constitutional exome analyses...
April 15, 2018: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29666618/reassortant-h5n1-avian-influenza-virus-bearing-pb2-gene-from-a-2009-pandemic-h1n1-exhibits-increased-pathogenicity-in-mice
#15
Xian Lin, Shiman Yu, Kelei Guo, Xin Sun, Haiming Yi, Meilin Jin
Reassortment is a key driving force of the evolution and host adaptation of the influenza virus. A(H1N1)pdm2009 (pdm09), a novel H1N1 influenza viral subtype, caused a pandemic in 2009. The strain was established in pig herds and cocirculated with the highly pathogenic H5N1 avian influenza virus. The coexistence of pdm09 with H5N1 raises concerns that reassortment may cause the development of novel viral strains with unpredictable virulence. Given that the viral polymerase subunit PB2 is a determinant of host range and pathogenicity, and that the substantial amino acid differences in PB2 between pdm09 and H5N1, including positions 590/591 and 271, which are shown to play key roles in enhanced polymerase activity in mammalian host cells, we generated a reassortant virus containing PB2 derived from a pdm09 (A/Liaoning/1/2009, LN/09) to investigate if pdm09-derived PB2 can function in a heterologous avian virus isolate as an adaptive strategy, with H5N1 (A/duck/Hubei/hangmei01/2006, HM/06) as the backbone...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29666300/a-pan-cancer-landscape-of-interactions-between-solid-tumors-and-infiltrating-immune-cell-populations
#16
David Tamborero, Carlota Rubio-Perez, Ferran Muiños, Radhakrishnan Sabarinathan, Josep Maria Piulats, Aura Muntasell, Rodrigo Dienstmann, Nuria Lopez-Bigas, Abel Gonzalez-Perez
PURPOSE: Throughout their development tumors are challenged by the immune system and they acquire features to evade its surveillance. A systematic view of these traits which sheds light on how tumors respond to immunotherapies is still lacking. EXPERIMENTAL DESIGN: Here, we computed the relative abundance of an array of immune cell populations to measure the immune infiltration pattern of 9,174 tumors of 29 solid cancers. We then clustered tumors with similar infiltration pattern to define immune-phenotypes...
April 17, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29666287/the-blast-fungus-decoded-genomes-in-flux
#17
Thorsten Langner, Aleksandra Białas, Sophien Kamoun
Plant disease outbreaks caused by fungi are a chronic threat to global food security. A prime case is blast disease, which is caused by the ascomycete fungus Magnaporthe oryzae (syn. Pyricularia oryzae ), which is infamous as the most destructive disease of the staple crop rice. However, despite its Linnaean binomial name, M. oryzae is a multihost pathogen that infects more than 50 species of grasses. A timely study by P. Gladieux and colleagues (mBio 9:e01219-17, 2018, https://doi.org/10.1128/mBio.01219-17) reports the most extensive population genomic analysis of the blast fungus thus far...
April 17, 2018: MBio
https://www.readbyqxmd.com/read/29666249/eif1-loop-2-interactions-with-met-trna-i-control-the-accuracy-of-start-codon-selection-by-the-scanning-preinitiation-complex
#18
Anil Thakur, Alan G Hinnebusch
The eukaryotic 43S preinitiation complex (PIC), bearing initiator methionyl transfer RNA (Met-tRNAi ) in a ternary complex (TC) with eukaryotic initiation factor 2 (eIF2)-GTP, scans the mRNA leader for an AUG codon in favorable context. AUG recognition evokes rearrangement from an open PIC conformation with TC in a "POUT " state to a closed conformation with TC more tightly bound in a "PIN " state. eIF1 binds to the 40S subunit and exerts a dual role of enhancing TC binding to the open PIC conformation while antagonizing the PIN state, necessitating eIF1 dissociation for start codon selection...
April 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29666239/individuals-institutions-and-innovation-in-the-debates-of-the-french-revolution
#19
Alexander T J Barron, Jenny Huang, Rebecca L Spang, Simon DeDeo
The French Revolution brought principles of "liberty, equality, fraternity" to bear on the day-to-day challenges of governing what was then the largest country in Europe. Its experiments provided a model for future revolutions and democracies across the globe, but this first modern revolution had no model to follow. Using reconstructed transcripts of debates held in the Revolution's first parliament, we present a quantitative analysis of how this body managed innovation. We use information theory to track the creation, transmission, and destruction of word-use patterns across over 40,000 speeches and a thousand speakers...
April 17, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29665918/-inhibitory-effect-of-histone-deacetylase-inhibitor-saha-on-proliferation-of-mouse-multiple-myeloma-cell-line-sp2-0-in-vitro-and-in-vivo
#20
Lei Huo, Chen-Yu Zhang, Yi-Fang Dang, Wan-Jun Zhang, Man-Man Liu, Lu-She Liu, Zun-Min Zhu, Na Fang, Shao-Ping Ji, Kai Sun
OBJECTIVE: To explore the anti-myeloma effect of suberoylanilide hydroxamic acid (SAHA) and on mouse myeloma cell line SP2/0 in vitro and in vivo and its mechanism. METHODS: The inhibitory effect of SAHA on SP2/0 cells was measured by CCK-8 assay,and the apoptosis and cell cycle were analyzed by flow cytometry FACS. The protein expression of Caspase-3 and p53 of SP2/0 cells treated with SAHA were examined by Western blot. Annexin V/7-AAD double staining was performed to detect the apoptosis of SP2/0 induced by SAHA in vitro...
April 2018: Zhongguo Shi Yan Xue Ye Xue za Zhi
keyword
keyword
66035
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"