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https://www.readbyqxmd.com/read/29908523/radiographic-study-of-haematogenous-septic-arthritis-in-dairy-calves
#1
Caroline Constant, Isabelle Masseau, Marie Babkine, Sylvain Nichols, David Francoz, Gilles Fecteau, Emma Marchionatti, Helene Larde, Andre Desrochers
OBJECTIVES:  (1) To develop an evaluation grid to provide a systematic interpretation of calves' articular radiographs, (2) to describe radiographic lesions of septic arthritis in dairy calves less than 6 months of age, (3) to investigate potential associations between demographic data or synovial bacteriological culture results and radiographic lesions (4) to determine whether an association is present between radiographic lesions, their severity and the long-term outcome. METHODS:  Medical records of 54 calves less than 180 days old treated for septic arthritis between 2009 and 2014 with radiographic images performed in the first 2 days after admission were reviewed...
June 16, 2018: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
https://www.readbyqxmd.com/read/29908487/dynamic-properties-of-hydrogels-and-fiber-reinforced-hydrogels
#2
Nicholas Martin, George Youssef
Hydrophilic polymers, or hydrogels, are used for a wide variety of biomedical applications, due to their inherent ability to withhold a high-water content. In recent years, a large effort has been focused on tailoring the mechanical properties of these hydrogels to become more appropriate materials for use as anatomical and physiological structural supports. A few of these such methods include using diverse types of polymers, both natural and synthetic, varying the type of molecular cross-linking, as well as combining these efforts to form interpenetrating polymer network hydrogels...
June 7, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29908441/synthesis-and-biological-evaluation-of-new-coumarins-bearing-2-4-diaminothiazole-5-carbonyl-moiety
#3
Adileh Ayati, Tayebeh Oghabi Bakhshaiesh, Setareh Moghimi, Rezvan Esmaeili, Keivan Majidzadeh-A, Maliheh Safavi, Loghman Firoozpour, Saeed Emami, Alireza Foroumadi
A series of new coumarin-containing compounds 3a-l and 4a-c was designed and synthesized based on the chalcone-type 4-amino-5-cinnamoylthiazole scaffold 2, and screened for their in vitro anticancer and antioxidant activities. Representatively, the 2-thiomorpholinothiazole derivative 3k with IC50 values of 7.5-16.9 μg/ml demonstrated good cytotoxic effects against tested cell lines MCF-7, HepG2 and SW480. Further investigation by flow cytometric analysis confirmed that this compound induces apoptotic cell death in MCF-7 cells and cause G1-phase arrest in the cell cycle...
June 7, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29908437/studies-on-2-phenylquinoline-staphylococcus-aureus-nora-efflux-pump-inhibitors-new-insights-on-the-c-6-position
#4
Tommaso Felicetti, Rolando Cannalire, Maria Giulia Nizi, Oriana Tabarrini, Serena Massari, Maria Letizia Barreca, Giuseppe Manfroni, Bryan D Schindler, Violetta Cecchetti, Glenn W Kaatz, Stefano Sabatini
The alarming and rapid spread of antimicrobial resistance among bacteria represents a high risk for global health. Targeting factors involved in resistance to restore the activity of failing antibiotics is a promising strategy to overcome this urgent medical need. Efflux pump inhibitors are able to increase antibiotic concentrations in bacteria, thus they can be considered true antimicrobial resistance breakers. In this work, continuing our studies on inhibitors of the Staphylococcus aureus NorA pump, we designed, synthesized and biologically evaluated novel 2-phenylquinoline derivatives starting from our hits 1 and 2...
June 6, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29908355/medial-acetabular-wall-breach-in-total-hip-arthroplasty-is-full-weight-bearing-possible
#5
Filippo Mandelli, Simon Tiziani, Jürgen Schmitt, Clément M L Werner, Hans-Peter Simmen, Georg Osterhoff
BACKGROUND: A breach of the medial acetabular wall is a phenomenon seen frequently due to over-reaming during total hip arthroplasty (THA). The consequences of this issue are not fully understood particularly in cementless THA. A retrospective study was performed to answer whether: 1) immediate postoperative full-weight bearing in the presence of a medial acetabular wall breach after THA results in more short-term revisions of the acetabular component, 2) increases the risk for migration of the acetabular component? HYPOTHESIS: Immediate full-weight bearing in the presence of a medial breach is not associated with an increased likelihood for acetabular-related revision surgery or migration of the cup...
June 13, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29908287/characterization-of-nanomedicines-surface-coverage-using-molecular-probes-and-capillary-electrophoresis
#6
J-B Coty, F Varenne, A Benmalek, O Garsaa, I Le Potier, M Taverna, C Smadja, C Vauthier
A faithful characterization of nanomedicine (NM) is needed for a better understanding of their in vivo outcomes. Size and surface charge are studied with well-established methods. However, other relevant parameters for the understanding of NM behavior in vivo remain largely inaccessible. For instance, the reactive surface of nanomedicines, which are often grafted with macromolecules to decrease their recognition by the immune system, is excluded from a systematic characterization. Yet, it is known that a subtle modification of NM's surface characteristics (grafting density, molecular architecture and conformation of macromolecules) is at the root of major changes in the presence of biological components...
June 13, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29908181/ppar-gamma-pathways-attenuate-pulmonary-granuloma-formation-in-a-carbon-nanotube-induced-murine-model-of-sarcoidosis
#7
Matthew McPeek, Anagha Malur, Debra A Tokarz, Gina Murray, Barbara P Barna, Mary Jane Thomassen
Peroxisome proliferator activated receptor gamma (PPARγ), a ligand activated nuclear transcription factor, is constitutively expressed in alveolar macrophages of healthy individuals. PPARγ deficiencies have been noted in several lung diseases including the alveolar macrophages of pulmonary sarcoidosis patients. We have previously described a murine model of multiwall carbon nanotube (MWCNT) induced pulmonary granulomatous inflammation which bears striking similarities to pulmonary sarcoidosis, including the deficiency of alveolar macrophage PPARγ...
June 13, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29907912/temporary-epiphysiodesis-using-the-flextack%C3%A2-implant-tension-band-featuring-a-modified-explantation-technique
#8
REVIEW
S Koob, M Kehrer, M Hettchen, T Jansen, J Schmolders, R Placzek
OBJECTIVE: Presenting the implantation of the PediatrOS™ FlexTack™ (Merete, Berlin, Germany) for growth guidance and a modified explantation procedure to facilitate explantation and prevent bone and soft tissue damage. INDICATIONS: Implantation: Genua vara and valga, coxa vara, varus and valgus deviation of the ankle joint, the elbow joint and the wrist Modified Explantation: Removal of the implant after successful limb correction or dislocation of the implant...
June 15, 2018: Operative Orthopädie und Traumatologie
https://www.readbyqxmd.com/read/29907786/a-gene-co-expression-network-model-identifies-yield-related-vicinity-networks-in-jatropha-curcas-shoot-system
#9
Nisha Govender, Siju Senan, Zeti-Azura Mohamed-Hussein, Ratnam Wickneswari
The plant shoot system consists of reproductive organs such as inflorescences, buds and fruits, and the vegetative leaves and stems. In this study, the reproductive part of the Jatropha curcas shoot system, which includes the aerial shoots, shoots bearing the inflorescence and inflorescence were investigated in regard to gene-to-gene interactions underpinning yield-related biological processes. An RNA-seq based sequencing of shoot tissues performed on an Illumina HiSeq. 2500 platform generated 18 transcriptomes...
June 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29907149/changes-in-bone-mineral-density-after-total-parathyroidectomy-without-autotransplantation-in-the-end-stage-renal-disease-patients-with-secondary-hyperparathyroidism
#10
Li Fang, Jining Wu, Jing Luo, Ping Wen, Mingxia Xiong, Jinlong Cao, Xiaolan Chen, Junwei Yang
BACKGROUND: The patients with secondary hyperparathyroidism (SHPT) usually had reduced bone mineral density, which might lead to a substantial increase in osteoporosis, fracture and mortality. Although surgical intervention is effective in reducing parathyroid hormone (PTH) levels in suitable candidates refractory to medical therapy, the effect of surgery on bone mass changes still requires further evaluation. Thus, the aim of this study was to evaluate the characteristics of BMD changes after total parathyroidectomy (PTX) without autotransplantation and its associated factors...
June 15, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29907135/doxorubicin-induced-cardiotoxicity-is-suppressed-by-estrous-staged-treatment-and-exogenous-17%C3%AE-estradiol-in-female-tumor-bearing-spontaneously-hypertensive-rats
#11
Kaytee L Pokrzywinski, Thomas G Biel, Elliot T Rosen, Julia L Bonanno, Baikuntha Aryal, Francesca Mascia, Delaram Moshkelani, Steven Mog, V Ashutosh Rao
BACKGROUND: Doxorubicin (DOX), an anthracycline therapeutic, is widely used to treat a variety of cancer types and known to induce cardiomyopathy in a time and dose-dependent manner. Postmenopausal and hypertensive females are two high-risk groups for developing adverse effects following DOX treatment. This may suggest that endogenous reproductive hormones can in part suppress DOX-induced cardiotoxicity. Here, we investigated if the endogenous fluctuations in 17β-estradiol (E2) and progesterone (P4) can in part suppress DOX-induced cardiomyopathy in SST-2 tumor-bearing spontaneously hypersensitive rats (SHRs) and evaluate if exogenous administration of E2 and P4 can suppress DOX-induced cardiotoxicity in tumor-bearing ovariectomized SHRs (ovaSHRs)...
June 15, 2018: Biology of Sex Differences
https://www.readbyqxmd.com/read/29907097/taxonomy-aware-feature-engineering-for-microbiome-classification
#12
Mai Oudah, Andreas Henschel
BACKGROUND: What is a healthy microbiome? The pursuit of this and many related questions, especially in light of the recently recognized microbial component in a wide range of diseases has sparked a surge in metagenomic studies. They are often not simply attributable to a single pathogen but rather are the result of complex ecological processes. Relatedly, the increasing DNA sequencing depth and number of samples in metagenomic case-control studies enabled the applicability of powerful statistical methods, e...
June 15, 2018: BMC Bioinformatics
https://www.readbyqxmd.com/read/29906764/end-of-life-healthcare-expenditure-testing-economic-explanations-using-a-discrete-choice-experiment
#13
Barbara Fischer, Harry Telser, Peter Zweifel
Healthcare expenditure (HCE) spent during an individual's last year of life accounts for a high share of lifetime HCE. This finding is puzzling because an investment in health is unlikely to have a sufficiently long payback period. However, Becker et al. (2007) and Philipson et al. (2010) have advanced a theory designed to explain high willingness to pay (WTP) for an extension of life close to its end. Their testable implications are complemented by the concept of 'pain of risk bearing' introduced by Eeckhoudt and Schlesinger (2006)...
June 7, 2018: Journal of Health Economics
https://www.readbyqxmd.com/read/29906737/achilles-tendon-loading-during-weight-bearing-exercises
#14
Naghmeh Gheidi, Thomas W Kernozek, John D Willson, Andrew Revak, Keith Diers
OBJECTIVE: Compare the estimated Achilles tendon (AT) loading using a musculoskeletal model during commonly performed weight bearing therapeutic exercises. DESIGN: Controlled laboratory study. SETTING: University biomechanics laboratory. PARTICIPANTS: Eighteen healthy males (Age:22.1 ± 1.8 years, height:177.7 ± 8.4 cm, weight = 74.29 ± 11.3 kg). MAIN OUTCOME MEASURE(S): AT loading was estimated during eleven exercises: tandem, Romberg, and unilateral standing, unilateral and bilateral heel raising, unilateral and bilateral jump landing, squat, lunge, walking, and running...
May 10, 2018: Physical Therapy in Sport
https://www.readbyqxmd.com/read/29906705/degradation-of-daxx-by-adenovirus-type-12-e1b-55k-circumvents-chemoresistance-of-ovarian-cancer-to-cisplatin
#15
Qiang Li, Junnai Wang, Daiqing Liao, Jihui Ai, Lei Jin, Qinglei Gao
Adenovirus E1B 55-kilodalton (E1B-55K) mediated DAXX degradation represents a potential mechanism by which E1B-55K sensitizes cancer cells to chemotherapy. Here we report the effects of E1B-55K-mediated DAXX degradation in chemoresistant ovarian cancer cells on response to chemotherapy. Cells with E1B-55K expression were more sensitive to cisplatin than cells without E1B-55K expression. In vivo C13* xenograft studies showed that the combination of cisplatin and E1B-55K was markedly more effective to slow tumor growth and to confer prolonged survival of tumor-bearing mice than either cisplatin or E1B-55K alone...
June 12, 2018: Virology
https://www.readbyqxmd.com/read/29906701/real-time-imaging-tracking-of-a-dual-fluorescent-drug-delivery-system-based-on-doxorubicin-loaded-globin-polyethylenimine-nanoparticles-for-visible-tumor-therapy
#16
Yan Zhang, Chang Wei, Feng Lv, Tianjun Liu
Elucidation of the pathway of drug delivery and carrier degradation in vivo is essential for the fabrication of a feasible drug delivery system. Multispectral fluorescence imaging can track a drug delivery system simultaneously based on the separation of fluorescence at multiple wavelengths without interference. In this study, the Doxorubicin loaded genipin-crosslinked globin and PEI nanoparticles (Gb-G-PEI/Dox NPs) were designed as a dual fluorescent drug delivery system to track the drug release and carrier degradation process...
June 6, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29905900/knee-alignment-in-adolescents-is-correlated-with-participation-in-weight-bearing-sports
#17
Laurens De Cock, Jan Dauwe, Lukas A Holzer, Johan Bellemans
PURPOSE: Weight-bearing sports might influence the alignment of the lower extremities during growth. The relationship between participation in weight-bearing sports and the alignment of the lower extremities in adolescents has not been adequately studied yet. The aim of the study was to investigate whether sports participation during growth in early adolescence is correlated with the development of genu varum. METHODS: The design was a correlation study in which 1008 (564 boys, 444 girls) healthy adolescents (from 12 to 19 years of age) were recruited in secondary schools...
June 15, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29905483/controlling-the-emissive-activity-in-heterocyclic-systems-bearing-c%C3%A2-p-bonds
#18
Sunandan Sarkar, John D Protasiewicz, Barry D Dunietz
The photophysical properties of a series of heteroatom substituted indoles are explored to identify chemical means to control their emissive activity. In particular, we consider impacts of changes in the conjugated backbone, where the C═N bonds of benzoxazoles are replaced by C═P bonds (benzoxaphospholes). The effects of extending the π-conjugation, incorporating various secondary heteroatoms (X-C═P), and enforcing planar rigidity are also examined. Our computational analysis explains the higher fluorescence efficiency observed with extended π-conjugation and highlights the importance of maintaining molecular planarity at both ground- and emissive-state geometries...
June 15, 2018: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/29905476/chemoselective-cyclopropanation-over-carbene-y-h-insertion-catalyzed-by-an-engineered-carbene-transferase
#19
Eric J Moore, Viktoria Steck, Priyanka Bajaj, Rudi Fasan
Hemoproteins have recently emerged as promising biocatalysts for promoting a variety of carbene transfer reactions including cyclopropanation and Y-H insertion (Y = N, S, Si, B). For these and synthetic carbene transfer catalysts alike, achieving high chemoselectivity toward cyclopropanation in olefin substrates bearing unprotected Y-H groups has proven remarkably challenging due to competition from the more facile carbene Y-H insertion reaction. In this report, we describe the development of a novel artificial metalloenzyme based on an engineered myoglobin incorporating a serine-ligated Co-porphyrin cofactor that is capable of offering high selectivity toward olefin cyclopropanation over N-H and Si-H insertion...
June 15, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29905461/a-scalable-synthesis-of-biodegradable-black-mesoporous-silicon-nanoparticles-for-highly-efficient-photothermal-therapy
#20
Wujun Xu, Konstantin Tamarov, Li Fan, Sari Granroth, Jimi Rantanen, Tuomo Nissinen, Sirpa Peräniemi, Oskari Uski, Maija-Riitta Hirvonen, Vesa-Pekka Lehto
Porous silicon (PSi) has attracted wide interest as a potential material for various fields of nanomedicine. However, until now, the application of PSi in photothermal therapy has not been successful due to its low photothermal conversion efficiency. In the present study, biodegradable black PSi (BPSi) nanoparticles were designed and prepared via a high yield and simple reaction. The BPSi nanoparticles possessed a low bandgap of 1.34 eV, a high extinction coefficient of 13.2 L g-1 cm-1 at 808 nm, a high photothermal conversion efficiency of 33...
June 15, 2018: ACS Applied Materials & Interfaces
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