keyword
MENU ▼
Read by QxMD icon Read
search

bear

keyword
https://www.readbyqxmd.com/read/28231701/the-potential-interaction-between-ewe-body-condition-score-and-nutrition-during-very-late-pregnancy-and-lactation-on-the-performance-of-twin-bearing-ewes-and-their-lambs
#1
Lydia Cranston, Paul Kenyon, Rene Corner-Thomas, Steve Morris
Objective: The present study aimed to determine the impact of ewe BCS (over a range of 2.0 to 3.0) and nutritional treatments (consisting of differing herbage masses) during very late pregnancy and lactation and their potential interaction on the performance of twin-bearing ewes and their lambs to weaning. Methods: On day [42 of pregnancy, twin-bearing ewes with a body condition score (BCS) of 2.0, 2.5 or 3.0 were allocated to a "Moderate' or 'Unrestricted' nutritional treatment until day 95 of lactation (weaning)...
February 23, 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28231653/implantless-fixation-of-a-large-osteocartilaginous-fracture-of-the-lateral-femoral-condyle-in-a-child
#2
Jitendra Maheshwari, Vikram Mhaskar, Parul Maheshwari Mhaskar
We describe for the first time a case of lateral femoral condyle fracture following a fall in a 13-year-old child that was reduced arthroscopically using a probe. It was definitively fixed with 0 vicryl sutures in a cruciate pattern after being initially stabilised with 1.5-mm Kirschner wires. Four beath pins carrying sutures were drilled at four opposing quadrants through the reduced fragment into the femur. The sutures were then tied on the lateral cortex of the femur. After fixation, the child was kept non-weight bearing for 6 weeks, partial weight bearing from 6 weeks to 12 weeks and then full weight bearing thereafter...
March 1, 2017: Knee Surgery & related Research
https://www.readbyqxmd.com/read/28231510/lipopolyplex-potentiates-anti-tumor-immunity-of-mrna-based-vaccination
#3
Stefano Persano, Maria L Guevara, Zhaoqi Li, Junhua Mai, Mauro Ferrari, Pier Paolo Pompa, Haifa Shen
mRNA-based vaccines have the benefit of triggering robust anti-cancer immunity without the potential danger of genome integration from DNA vaccines or the limitation of antigen selection from peptide vaccines. Yet, a conventional mRNA vaccine comprising of condensed mRNA molecules in a positively charged protein core structure is not effectively internalized by the antigen-presenting cells. It cannot offer sufficient protection for mRNA molecules from degradation by plasma and tissue enzymes either. Here, we have developed a lipopolyplex mRNA vaccine that consists of a poly-(β-amino ester) polymer mRNA core encapsulated into a 1,2-dioleoyl-sn-glycero-3-ethylphosphocholine/1,2-dioleoyl-sn-glycero-3-phosphatidyl-ethanolamine/1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-2000 (EDOPC/DOPE/DSPE-PEG) lipid shell...
February 20, 2017: Biomaterials
https://www.readbyqxmd.com/read/28231498/bone-specific-poly-ethylene-sodium-phosphate-bearing-biodegradable-nanoparticles
#4
Yuya Hirano, Yasuhiko Iwasaki
Chemotherapy is the most reliable treatment for osteoporosis and osseous metastases. To facilitate better drug delivery for bone treatments, a novel preparation of polymeric nanoparticles with high affinity to bone has been prepared. Two-step synthesis of cholesteryl-functionalized poly(ethylene sodium phosphate) (Ch-PEPn·Na) was performed via ring-opening polymerization of cyclic phosphoesters and the demethylation. The molecular weight of Ch-PEPn·Na could be well controlled by changing the ratio of cholesterol and cyclic phosphoesters...
February 16, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28230872/the-load-bearing-ability-of-a-particle-raft-under-the-transverse-compression-of-a-slender-rod
#5
Pingcheng Zuo, Jianlin Liu, Shanpeng Li
Liquid marbles and particle rafts are liquid interfaces covered with tiny particles, which are accompanied with many exotic behaviors. This study seeks to extend our understanding on the load-bearing ability of a particle raft under the transverse compression of a slender rod. At first, the interface morphologies of the particle raft and water are captured and compared with each other. Then the load-distance curves of the particle raft and water surface are measured using a self-developed device. For the particle raft, the hydrophobicity of the rod almost does not affect the interface morphology and the supporting load...
February 23, 2017: Soft Matter
https://www.readbyqxmd.com/read/28230661/predicting-progression-in-barrett-s-esophagus-development-and-validation-of-the-barrett-s-esophagus-assessment-of-risk-score-bear-score
#6
Craig S Brown, Brittany Lapin, Jay L Goldstein, John G Linn, Mark S Talamonti, Joann Carbray, Michael B Ujiki
OBJECTIVE: To develop and validate a scoring tool capable of accurately predicting which patients with Barrett's esophagus (BE) will progress to dysplasia and/or esophageal adenocarcinoma. BACKGROUND: Endoscopic therapies have emerged capable of eradicating BE with high efficacy and low complication rates, but which patients should receive treatment is still debated. Current knowledge of risk factors is insufficient to allow for the accurate prediction of which patients will progress to dysplasia or adenocarcinoma...
February 22, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28230375/three-component-coupling-of-triflyloxy-substituted-benzocyclobutenones-organolithium-reagents-and-arynophiles-promoted-by-generation-of-aryne-via-carbon-carbon-bond-cleavage
#7
Keisuke Uchida, Suguru Yoshida, Takamitsu Hosoya
Treatment of benzocyclobutenones bearing a triflyloxy group adjacent to the four-membered ring with organolithium reagents in the presence of arynophiles efficiently affords three-component coupled α-arylketones. Mechanistic studies indicate that the reaction is promoted by generation of the aryne via carbon-carbon bond cleavage of a benzocyclobutenoxide intermediate, which led us to find a fluoride-mediated aryne generation method from triflyloxy-substituted benzocyclobutenone silyl acetal precursors.
February 23, 2017: Organic Letters
https://www.readbyqxmd.com/read/28230371/asymmetric-catalytic-1-2-hydroperoxidation-of-isatin-derived-ketimine-with-hydrogen-peroxide-in-the-crowding-environment-of-pegs
#8
Wengang Guo, Yan Liu, Can Li
The first enantioselective catalytic 1,2-hydroperoxidation has been achieved in the presence of PEG-600 using an acid-base bifunctional chiral squaramide as the organocatalyst, affording a range of enantioenriched α-N-substituted hydroperoxides bearing an oxindole moiety with excellent stereoselectivities (up to 99% ee).
February 23, 2017: Organic Letters
https://www.readbyqxmd.com/read/28230369/synthesis-of-substituted-%C3%AE-and-%C3%AE-lactams-via-pd-catalyzed-alkene-carboamination-reactions
#9
Jordan R Boothe, Yifan Shen, John P Wolfe
The synthesis of substituted γ- and δ-lactams via palladium-catalyzed alkene carboamination reactions between aryl halides and alkenes bearing pendant amides is described. The substrates for these reactions are generated in 1-3 steps from commercially available materials, and products are obtained in good yield with up to >20:1 diastereoselectivity. The stereochemical outcome of the alkene addition is consistent with a mechanism involving anti-aminopalladation of the alkene.
February 23, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28230303/unexpectedly-facile-rh-i-catalyzed-polymerization-of-ethynylbenzaldehyde-type-monomers-synthesis-of-polyacetylenes-bearing-reactive-and-easy-transformable-pendant-carbaldehyde-groups
#10
Jan Sedláček, Lucie Havelková, Jiří Zedník, Radek Coufal, Tomáš Faukner, Hynek Balcar, Jiří Brus
The chain coordination polymerization of (ethynylarene)carbaldehydes with unprotected carbaldehyde groups, namely ethynylbenzaldehydes, 1-ethynylbenzene-3,5-dicarboxaldehyde, and 3-[(4-ethynylphenyl)ethynyl]benzaldehyde, is reported for the first time. Polymerization is catalyzed with various Rh(I) catalysts and yields poly(arylacetylene)s with one or two pendant carbaldehyde groups per monomeric unit. Surprisingly, the carbaldehyde groups of the monomers do not inhibit the polymerization unlike the carbaldehyde group of unsubstituted benzaldehyde that acts as a strong inhibitor of Rh(I) catalyzed polymerization of arylacetylenes...
February 23, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/28230280/rearrangement-of-a-transient-gold-vinylidene-into-gold-carbenes
#11
Alois Fürstner, Wouter Debrouwer
The gold acetylide complex 20 endowed with a biaryl backbone provides opportunities for a study on the formation and fate of gold vinylidenes. While the formyl group in 20 per se is not sufficiently electrophilic to get attacked by the acetylide in proximity, its activation with TBSOTf at low temperature triggered instantaneous formation of a gold vinylidene (21). This metastable species evolved into the cationic gold carbene complex 22 bearing a phenanthrene unit and a hydroxyl group at the aurated center; the recorded data suggest that this product might be better viewed as an acylgold species protonated by triflic acid...
February 23, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28230246/functional-and-evolutionary-consequences-of-cranial-fenestration-in-birds
#12
Sander W S Gussekloo, Michael A Berthaume, Daniel R Pulaski, Irene Westbroek, Jan H Waarsing, Robin Heinen, Ian R Grosse, Elizabeth R Dumont
Ostrich-like birds (Palaeognathae) show very little taxonomic diversity while their sister taxon (Neognathae) contains roughly 10000 species. The main anatomical differences between the two taxa are in the crania. Palaeognaths lack an element in the bill called the lateral bar that is present in both ancestral theropods and modern neognaths, have thin zones in the bones of the bill, and robust bony elements on the ventral surface of their crania. Here we use a combination of modelling and developmental experiments to investigate the processes that might have led to these differences...
February 23, 2017: Evolution; International Journal of Organic Evolution
https://www.readbyqxmd.com/read/28229961/neurospora-tetrasperma-crosses-heterozygous-for-hybrid-translocation-strains-produce-rare-eight-spored-asci-bearing-heterokaryotic-ascospores
#13
Durgadas P Kasbekar, Selvam Rekha
During ascogenesis in Neurospora, the ascospores are partitioned at the eight-nucleus stage that follows meiosis and a post-meiotic mitosis, and the ascospores that form in eight-spored asci are usually homokaryotic. We had previously created novel TNt strains by introgressing four Neurospora crassa insertional translocations (EB4, IBj5, UK14-1, and B362i) into N. tetrasperma. We now show that crosses of all the TNt strains with single-mating-type derivatives of the standard N. tetrasperma pseudohomothallic strain 85 (viz...
March 2017: Journal of Biosciences
https://www.readbyqxmd.com/read/28229494/cobalt-catalyzed-regioselective-borylation-of-arenes-n-heterocyclic-silylene-as-electron-donors-in-metal-mediated-activation-of-c%C3%AF-h-bonds
#14
Chunming Cui, Hailong Ren, Yu-Peng Zhou, Yun-Ping Bai, Matthias Driess
C-H Borylation of arenes has been a subject of great current interest because of its atom-economy and the wide applicability of borylated products in value-added synthesis. A new bis(silylene)cobalt(II) complex bearing a bis(N-heterocyclic silylene)-pyridine pincer ligand (SiNSi) has been synthesized and structurally characterized. It enabled the regioselective catalytic C-H borylation of pyridines, furans and fluorinated arenes. Notably, it exhibited the complementary regioselectivity for the borylation of fluorinated arenes compared to previously known catalytic systems, demonstrating that N-heterocyclic silylene donors have enormous potential in metal-catalyzed catalytic applications...
February 23, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28229434/preclinical-pharmacokinetics-and-pharmacodynamics-of-pinometostat-epz-5676-a-first-in-class-small-molecule-s-adenosyl-methionine-competitive-inhibitor-of-dot1l
#15
Nigel J Waters
Acute leukemias bearing mixed lineage leukemia (MLL) rearrangements are aggressive diseases characterized by a poor overall prognosis despite multi-agent chemotherapy. Aberrant fusion proteins involving the MLL histone methyltransferase (HMT) lead to recruitment of DOT1L, to a multi-protein complex resulting in aberrant methylation of histone H3 lysine 79 at MLL target genes, and ultimately enhanced expression of critical genes for hematopoietic differentiation, including HOXA9 and MEIS1, and as such defines the established mechanism for leukemogenesis in MLL-rearrangement (MLL-r) leukemias...
February 22, 2017: European Journal of Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/28229355/femoral-shaft-osteotomy-for-obligate-outward-rotation-due-to-scfe
#16
Peter M Stevens, Lucas Anderson, Bruce A MacWilliams
Slipped capital femoral epiphysis (SCFE) is an adolescent disease that leads to retroversion of the femoral neck and shaft, relative to the head. Observing that patients with SCFE must walk with an outward foot progression angle and externally rotate the leg in order to flex the hip, we have been performing a femoral shaft rotational osteotomy wherein we rotate the lower femur 45° inward, relative to the upper femur. By correcting retroversion, our goal is to improve functional hip and knee motion, thereby mitigating the effects of SCFE impingement...
February 22, 2017: Strategies in Trauma and Limb Reconstruction
https://www.readbyqxmd.com/read/28229277/ginger-extract-adjuvant-to-doxorubicin-in-mammary-carcinoma-study-of-some-molecular-mechanisms
#17
Nahla E El-Ashmawy, Naglaa F Khedr, Hoda A El-Bahrawy, Hend E Abo Mansour
PURPOSE: The present study aimed to investigate the molecular mechanisms underlying the anticancer properties of ginger extract (GE) in mice bearing solid Ehrlich carcinoma (SEC) and to evaluate the use of GE in combination with doxorubicin (DOX) as a complementary therapy against SEC. METHODS: SEC was induced in 60 female mice. Mice were divided into four equal groups: SEC, GE, DOX and GE + DOX. GE (100 mg/kg orally day after day) and DOX (4 mg/kg i.p. for 4 cycles every 5 days) were given to mice starting on day 12 of inoculation...
February 22, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28229276/effects-of-chlorella-vulgaris-on-tumor-growth-in-mammary-tumor-bearing-balb-c-mice-discussing-association-of-an-immune-suppressed-protumor-microenvironment-with-serum-ifn%C3%AE-and-igg-decrease-and-spleen-igg-potentiation
#18
Ahad Khalilnezhad, Elham Mahmoudian, Nariman Mosaffa, Ali Anissian, Mohsen Rashidi, Davar Amani
PURPOSE: Chlorella vulgaris (CV) has exhibited immune-enhancing and protective activities against cancer and infections. However, there is an increasing concern about the use of Chlorella species in human, regarding its various molecules with antigenic features found in infectious microorganisms. Our goal was to investigate the impact of higher concentrations of CV on tumor growth in spontaneous mouse mammary tumor (SMMT) models. METHODS: Balb/c mice were daily given CV powder at doses of 0, 200, or 300 mg/kg for 42 days (CONTROL, CV200, and CV300 groups, respectively; n = 6/group)...
February 22, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28229225/implications-of-sdhb-genetic-testing-in-patients-with-sporadic-pheochromocytoma
#19
Aurelie Maignan, Carole Guerin, Valentin Julliard, Nunzia-Cinzia Paladino, Edward Kim, Philippe Roche, Fréderic Castinetti, Wassim Essamet, Julien Mancini, Alessio Imperiale, Roderick Clifton-Bligh, Pauline Romanet, Anne Barlier, Karel Pacak, Fréderic Sebag, David Taïeb
PURPOSE: Succinate dehydrogenase B (SDHB) associated pheochromocytomas (PHEOs) are associated with a higher risk of tumor aggressiveness and malignancy. The aim of the present study was to evaluate (1) the frequency of germline SDHB mutations in apparently sporadic patients with PHEO who undergo preoperative genetic testing and (2) the ability to predict pathogenic mutations. METHODS: From 2012 to 2016, 82 patients underwent a PHEO surgical resection. Sixteen were operated in the context of hereditary PHEO and were excluded from analysis...
February 22, 2017: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/28229193/osseointegrated-prostheses-for-rehabilitation-following-amputation-the-pioneering-swedish-model
#20
Yan Li, Rickard Brånemark
The direct attachment of osseointegrated (OI) prostheses to the skeleton avoids the inherent problems of socket suspension. It also provides physiological weight bearing, improved range of motion in the proximal joint, as well as osseoperceptive sensory feedback, enabling better control of the artificial limbs by amputees. The present article briefly reviews the pioneering efforts on extremity osseointegration surgeries in Sweden and the development of the OPRA (Osseointegrated Prostheses for the Rehabilitation of Amputees) program...
February 22, 2017: Der Unfallchirurg
keyword
keyword
66035
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"