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Emilie M Flament, Keith R Berend, Jason M Hurst, Michael J Morris, Joanne B Adams, Adolph V Lombardi
BACKGROUND: In past decades, polyethylene wear was a major cause of failure in total knee arthroplasty (TKA). Polyethylene for use in arthroplasty has been vastly improved in recent years, with improved materials as well as manufacturing and sterilization processes. Testing has shown that infusion of vitamin E prevents oxidative degradation of polyethylene without remelting, allowing the material to maintain mechanical properties and wear resistance over time. The purpose of this study is to review the early result of patients undergoing primary TKA with vitamin E antioxidant-infused polyethylene inserts...
October 26, 2016: Surgical Technology International
Evan A Dubiel, Bruno Martin, Sylvain Vigier, Patrick Vermette
A quartz crystal microbalance (QCM) was constructed to assess if such a biosensor has value as a complementary real-time label-free analysis platform for the biopharmaceutical industry. This was achieved through modifying QCM crystals with a low-fouling carboxymethyl-dextran layer bearing Protein A, and then injecting solutions containing Etanercept (i.e., Enbrel(®)) into the QCM chambers. The kinetics of Enbrel(®) - Protein A interactions was modeled using the Langmuir binding model and Enbrel(®) concentrations between 0...
October 19, 2016: Colloids and Surfaces. B, Biointerfaces
V L Shirokova, A M L Enright, C B Kennedy, F G Ferris
This investigation evaluates spatial relationships between summer (July) groundwater temperatures and Fe(II)/Fe(III) biogeochemical cycling over a five year period in a shallow pristine sand aquifer at Meilleurs Bay near Deep River, Ontario, Canada. A warm subsurface thermal island of 12.5-16.1 °C, compared to background conditions of 10-11 °C, was manifest in contour maps of average groundwater temperature over the study period. The warm zone coincided with an area of convergent groundwater flow, implicating horizontal heat transfer by advective convection as the reason for elevated temperatures...
October 19, 2016: Water Research
Daniel M Bear, Jean-Marc Lassance, Hopi E Hoekstra, Sandeep Robert Datta
Evolution sculpts the olfactory nervous system in response to the unique sensory challenges facing each species. In vertebrates, dramatic and diverse adaptations to the chemical environment are possible because of the hierarchical structure of the olfactory receptor (OR) gene superfamily: expansion or contraction of OR subfamilies accompanies major changes in habitat and lifestyle; independent selection on OR subfamilies can permit local adaptation or conserved chemical communication; and genetic variation in single OR genes can alter odor percepts and behaviors driven by precise chemical cues...
October 24, 2016: Current Biology: CB
Jessica S Dalley, Patricia R Creary, Tiffany Durzi, C Meghan McMurtry
Although there are existing guidelines for teaching and learning skillful client communication, there remains a need to integrate a developmental focus into veterinary medical curricula to prepare students for interactions with children who accompany their companion animals. The objectives of this Teaching Tip are (1) to describe the use of a Teddy Bear Clinic Tour as an innovative, applied practice method for teaching veterinary students about clinical communication with children, and (2) to provide accompanying resources to enable use of this method to teach clinical communication at other facilities...
October 25, 2016: Journal of Veterinary Medical Education
Masahiko Horiba, Takao Yamaguchi, Satoshi Obika
We previously reported the synthesis and evaluation of 2'-O,4'-C-spirocyclopropylene-bridged nucleic acid (scpBNA) bearing a thymine (T) nucleobase. Oligonucleotides (ONs) modified with scpBNA-T exhibited strong binding affinity to complementary single-stranded RNA (ssRNA) and high enzymatic stability. These biophysical properties suggest that scpBNAs are well suited for use in antisense strategies. Herein we describe the synthesis of scpBNA monomers bearing 5-methylcytosine (mC), adenine (A), and guanine (G) nucleobases for use in a variety of sequences...
October 25, 2016: Journal of Organic Chemistry
Alice C Chang, Armen H Mekhdjian, Masatoshi Morimatsu, Aleksandra Kirillovna Denisin, Beth L Pruitt, Alexander R Dunn
Integrins mediate cell adhesion to the extracellular matrix and enable the construction of complex, multicellular organisms, yet fundamental aspects of integrin-based adhesion remain poorly understood. Notably, the magnitude of the mechanical load experienced by individual integrins within living cells is unclear, due principally to limitations inherent to existing techniques. Here we use FRET-based molecular tension sensors (MTSs) to directly measure the distribution of loads experienced by individual integrins in living cells...
October 25, 2016: ACS Nano
Yoshiaki Nishibayashi, Masahiro Yuki, Ken Sakata, Shoma Kikuchi, Hiroyuki Kawai, Tsuyoshi Takahashi, Masaki Ando, Kazunari Nakajima
Thiolate-bridged diruthenium complexes bearing pendent ethers have been found to work as effective catalysts toward the oxidation of molecular dihydrogen into protons and electrons in water. The pendent ether moiety in the complex plays an important role to facilitate the proton transfer between metal center and external proton acceptor.
October 25, 2016: Chemistry: a European Journal
Chi-Hung R Or, Hong-Lin Su, Wee-Chyan Lee, Shu-Yi Yang, Cheesang Ho, Chia-Che Chang
Melanoma is the most aggressive skin malignancy with a high rate of mortality and is frequently refractory to many therapeutics, thus demanding the discovery of novel effective anti-melanoma agents. Diphenhydramine (DPH) is an H1 histamine receptor antagonist and a relatively safe drug. Previous studies have revealed the in vitro cytotoxicity of DPH against melanoma cells, but the mechanisms involved concerning its cytotoxicity and the in vivo anti-melanoma effect remain unknown. We herein present the first evidence supporting that DPH is selectively proapoptotic for a panel of melanoma cell lines irrespective of BRAFV600E status while sparing normal melanocytes...
October 25, 2016: Oncology Reports
Chun-Hao Li, Sa-Hoe Lim, Hyang-Hwa Ryu, Kyung-Sub Moon, Tae-Young Jung, Shin Jung
Stereotactic radiosurgery has been recognized as an effective treatment approach for metastatic brain tumors. By increasing the sensitivity of the tumor to radiation and decreasing the marginal dose, it is possible to improve therapeutic efficacy and decrease side-effects. In radiation-induced cells, c-Jun N-terminal kinase (JNK) signaling mediates the phosphorylation of H2AX, which indicates DNA damage sensitivity and modulates the effect of radiation. Lewis lung cancer (LLC) and breast cancer (4T1) cells were irradiated with a Gamma Knife in cell culture tubes...
October 25, 2016: Oncology Reports
Lorenzo Ferri, Giuseppina Covello, Anna Caciotti, Renzo Guerrini, Michela Alessandra Denti, Amelia Morrone
Fabry disease is a rare X-linked lysosomal storage disorder caused by deficiency of the α-galactosidase A (α-Gal A) enzyme, which is encoded by the GLA gene. GLA transcription in humans produces a major mRNA encoding α-Gal A and a minor mRNA of unknown function, which retains a 57-nucleotide-long cryptic exon between exons 4 and 5, bearing a premature termination codon. NM_000169.2:c.639+861C>T and NM_000169.2:c.639+919G>A GLA deep intronic mutations have been described to cause Fabry disease by inducing overexpression of the alternatively spliced mRNA, along with a dramatic decrease in the major one...
October 25, 2016: Molecular Therapy. Nucleic Acids
E Ilett, T Kottke, J Thompson, K Rajani, S Zaidi, L Evgin, M Coffey, C Ralph, R Diaz, H Pandha, K Harrington, P Selby, R Bram, A Melcher, R Vile
The anti-tumor effects associated with oncolytic virus therapy are mediated significantly through immune-mediated mechanisms which depends both on the type of virus and the route of delivery. Here, we show that intra-tumoral (i.t.) oncolysis by Reovirus induced the priming of a CD8+, Th1-type anti-tumor response. In contrast, systemically delivered VSV expressing a cDNA library of melanoma antigens (VSV-ASMEL) promoted a potent anti-tumor CD4+ Th17 response. Therefore, we hypothesised that combining the Reovirus-induced CD8+ T cell response, with the VSV-ASMEL CD4+ Th17 helper response, would produce enhanced anti-tumor activity...
October 25, 2016: Gene Therapy
Rajeev K Dubey, Nick Westerveld, Stephen J Eustace, Ernst J R Sudhölter, Ferdinand C Grozema, Wolter F Jager
Nucleophilic aromatic substitution reactions on 1,7-dibromoperylene-3,4,9,10-tetracarboxylic monoimide dibutylester, using phenol and pyrrolidine reagents, have been exploited to synthesize perylenes with four different substituents at the perylene core. The first substitution is always regiospecific at the imide-activated 7-position. A second substitution reaction does not always replace the bromine at C-1, but may replace a phenol substituent at the highly activated 7-position. Exploiting this reactivity pattern, a "mixed" 1,7-diphenoxy, 1,7-dipyrrolidinyl, and two 1-phenoxy-7-pyrrolidinyl derivatives have been synthesized...
October 25, 2016: Organic Letters
Nitsch Jörn, Lando P Wolters, Celia Fonseca Guerra, F Matthias Bickelhaupt, Andreas Steffen
We aim to understand the electronic factors determining the stability and coordination number of d10 transition metal complexes bearing N-heterocyclic carbene (NHC) ligands, with a particular emphasis on higher coordinated species. In this DFT study on the formation and bonding of group 9-12 d10-[M(NHC)n] (n = 1-4) complexes, we found that all metals form very stable [M(NHC)2], but further coordination on the specific interplay of (i) the interaction energy (ΔEint) between the M(NHC)n-1 fragment and the incoming NHC ligand, and (ii) the strain energy ΔEstrain associated with bending the linear NHC-M-NHC arrangement...
October 25, 2016: Chemistry: a European Journal
Pengfei Li, Jindian Duan, Yuyu Cheng, Jing Cheng, Rou Li
A new method has been developed for the organocatalytic enantioselective benzylation and aldol-hemiacetalization of α,β-unsaturated trifluoromethyl ketones with toluene derivatives in the presence of a tertiary amine-thiourea catalyst. This method represents a facile and efficient strategy for the asymmetric synthesis of optically active 3,4-dihydroisocoumarins bearing a trifluoromethylated tetrasubstituted carbon stereocenter with high enantioselectivity. Notably, this strategy was used to synthesize several chiral trifluoromethylated analogues of typharin with high efficiency...
October 25, 2016: Chemistry: a European Journal
Yao Liu, Chu-Jun Zhou, Qingjiang Li, Honggen Wang
The first total synthesis of structurally unique polycyclic phenolic meroterpenoids, ganocins B and C is reported. The synthesis features gold-catalyzed intramolecular cascade cyclization to construct the C/D ring bearing an angular methyl group, diastereoselective Michael addition, and acid-mediated one-pot Robinson cyclization/deprotection/isomerization.
October 25, 2016: Organic & Biomolecular Chemistry
A Zechner, M Stock, D Kellner, I Ziegler, P Keuschnigg, P Huber, U Mayer, F Sedlmayer, H Deutschmann, P Steininger
Image guidance during highly conformal radiotherapy requires accurate geometric calibration of the moving components of the imager. Due to limited manufacturing accuracy and gravity-induced flex, an x-ray imager's deviation from the nominal geometrical definition has to be corrected for. For this purpose a ball bearing phantom applicable for nine degrees of freedom (9-DOF) calibration of a novel cone-beam computed tomography (CBCT) scanner was designed and validated. In order to ensure accurate automated marker detection, as many uniformly distributed markers as possible should be used with a minimum projected inter-marker distance of 10 mm...
November 21, 2016: Physics in Medicine and Biology
Maria Giovanna Sabbieti, Alessandra Dubbini, Fulvio Laus, Emanuele Paggi, Andrea Marchegiani, Melania Capitani, Luigi Marchetti, Fabrizio Dini, Tina Vermonden, Piera Di Martino, Dimitrios Agas, Roberta Censi
The present study reports on the biocompatibility in vivo after intramuscular and subcutaneous administration in Balb/c mice of vinyl sulphone bearing p(HPMAm-lac1-2)-PEG-p(HPMAm-lac1-2)/thiolated hyaluronic acid hydrogels, designed as novel injectable biomaterials for potential application in the fields of tissue engineering and regenerative medicine. Ultrasonography, used as a method to study hydrogel gelation and residence time in vivo, showed that, upon injection, the biomaterial efficiently formed a hydrogel by simultaneous thermal gelation and Michael Addition cross-linking forming a viscoelastic spherical depot at the injection site...
October 24, 2016: Journal of Tissue Engineering and Regenerative Medicine
Simin Zhang, Yanmei Zheng, Shengyan Yin, Jingzhi Sun, Bao Li, Lixin Wu
In this study, a uniform complex dual micelle bearing gadolinium substituted polyoxometalate core, hydrophobic middle, and biocompatible organic shell, which exhibited a uniform size and definite molecular weight and chemical composition, was constructed for fluorescent and magnetic resonance imaging contrast agent, via a simple two-step preparation. A paramagnetic polyoxometalate cluster K13[Gd(β2-SiW11O39)2] was firstly encapsulated with a cationic dendron in 3-generation (D-3) bearing triethylene glycol monomethyl ether terminal groups through ionic substitution...
October 24, 2016: Chemistry: a European Journal
Aleksandar Ž Kostić, Lazar M Kaluđerović, Biljana P Dojčinović, Miroljub B Barać, Vojka B Babić, Marina P Mačukanović-Jocić
BACKGROUND: Bee pollen has already proved to be a good supplement rich in content of iron and zinc. Studies about application of flower pollen in food industry and medicine have been started. Bearing in mind prevalence of maize as crop culture its pollen will be easily available. The mineral composition of pollen of seven Serbian maize hybrids was analyzed in order to establish its nutritional value and benefits of its implementation in the human diet using ICP method. RESULTS: Presence of twenty four different macro- (nine) and micronutrients (fifteen) was detected...
October 24, 2016: Journal of the Science of Food and Agriculture
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