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Chao-Chao Liu, Golam Jalal Ahammed, Guo-Ting Wang, Chang-Jie Xu, Kun-Song Chen, Yan-Hong Zhou, Jing-Quan Yu
Blue light photoreceptors, cryptochromes (CRYs), regulate multiple aspects of plant growth and development. However, our knowledge of CRYs is predominantly based on model plant Arabidopsis at early growth stage. In this study, we elucidated functions of CRY1a gene in mature tomato (Solanum lycopersicum) plants by using cry1a mutants and CRY1a overexpressing lines (OE-CRY1a-1 and OE-CRY1a-2). In comparison with wild-type plants, cry1a mutants are relatively tall, accumulate low biomass and bear more fruits, whereas OE-CRY1a plants are short stature, and they not only flower lately but also bear less fruits...
October 18, 2017: Plant, Cell & Environment
W Y Zhang, H Hu, X P Zhang, Y R Sun, H R Wang, K X Xu
OBJECTIVE: To compare the feasibility and prognosis of different surgical methods used for vesicovaginal fistulas and to explore the value of electrocoagulation treating small ones. METHODS: The medical data of 19 patients who had undertaken transvaginal VVF repairs in Peking University People's Hospital between October 2008 and November 2016 were retrospectively collected. The follow-ups were performed. The patients' age ranged from 31 to 55 years with the median age of 48 years and the history length ranged from 1 month to 24 months with the median length of 3 months...
October 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
Boon Huat Cheah, Sudhir Jadhao, Madavan Vasudevan, Ratnam Wickneswari, Kalaivani Nadarajah
A cross between IR64 (high-yielding but drought-susceptible) and Aday Sel (drought-tolerant) rice cultivars yielded a stable line with enhanced grain yield under drought screening field trials at International Rice Research Institute. The major effect qDTY4.1 drought tolerance and yield QTL was detected in the IR77298-14-1-2-10 Backcrossed Inbred Line (BIL) and its IR87705-7-15-B Near Isogenic Line (NIL) with 93.9% genetic similarity to IR64. Although rice yield is extremely susceptible to water stress at reproductive stage, currently, there is only one report on the detection of drought-responsive microRNAs in inflorescence tissue of a Japonica rice line...
2017: PloS One
Juan Casado, Maude Desroches, Paula Mayorga Burrezo, Joel Boismenu-Lavoie, Miriam Peña Alvarez, Carlos Gómez Garcia, Jon Mattin Matxain, David Casanova, Jean Francois Morin
New anthanthrone-based polycyclic scaffolds possessing peripheral crowed quinodimethanes have been prepared. While the compounds adopt a closed-shell butterfly shaped structure in the ground state, a curved-to-planar fluxional dynamic inversion is accessible with a low energy barrier through a diradical transition-state. Mainly driven by the release of strain attributed to the steric hindrance at the peri position of the anthanthrone core, a low-lying diradical state is accessible through planarization of the core...
October 18, 2017: Angewandte Chemie
Jana Vaculova, Jiri Gallo, Pavel Hurnik, Oldrich Motyka, Stuart B Goodman, Jana Dvorackova
The type of tissue response to implant by-products can be determined by examination of periprosthetic tissues. However, little is known about the most suitable location for tissue sampling. The main goal of this study was to evaluate the extent of variability in tissue response in relation to location of tissue sampling, implant fixation, age and sex in total joint arthroplasties with metal-on-polyethylene or ceramic-on-polyethylene bearing pairs. We processed 236 histology slides from 21 patients and focused on the association between the location of tissue samples and histological features...
October 16, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Dieter Enders, Ugur Kaya, Pankaj Chauhan, Suruchi Mahajan, Kristina Deckers, Arto Valkonen, Kari Rissanen
Pyrazolin-5-one derived N-Boc ketimines have been explored to develop an unprecedented domino aza-Friedel-Crafts/N,O-acetalization reaction with 2-naphthols. The novel protocol requires only a catalyst loading of 0.5 mol% of a bifunctional squaramide catalyst, is scalable to gram amounts, and provides a new series of furanonaphthopyrazolidinone derivatives bearing two vicinal tetra-substituted stereogenic centers in excellent yields (95-98%) and stereoselectivities (>99:1 dr and 97-98% ee). A different reactivity was observed in the case of 1-naphthols and other electron-rich phenols, which led to the aza-Friedel-Crafts adducts in 70-98% yield and 47-98% ee...
October 17, 2017: Angewandte Chemie
Erik B Pinxterhuis, Paco Visser, Iwan Esser, Jean-Baptiste Gualtierotti, Ben L Feringa
The homocoupling of aryl halides and the heterocoupling of aryl halides with either aryl bromides or arenes bearing an ortho-lithiation directing group are presented. The use of a Pd catalyst, in combination with t-BuLi, allows for the rapid and efficient formation of a wide range of polyaromatic compounds in a one pot procedure bypassing the need for the separate preformation of an organometallic coupling partner. These polyaromatic structures are obtained in high yields, in 10 min at room temperature, with minimal waste generation (E-factors as low as 1...
October 18, 2017: Angewandte Chemie
Yingxi Xu, Xiaoli Dong, Pingping Qi, Yujie Ye, Wenzhi Shen, Liang Leng, Lina Wang, Xuefei Li, Xiaohe Luo, Yanan Chen, Peiqing Sun, Rong Xiang, Na Li
As an important component of tumor microenvrionment, CD4(+) CD25(+) Tregs reduce antitumor immunity, promote angiogenesis and metastasis in breast cancer. However, their function in regulating the "stemness" of tumor cells and the communication between Tregs and cancer stem cells (CSCs) remain elusive. Here, we disclose that the primarily cultured Tregs isolated from breast-tumor-bearing Foxp3-EGFP mouse up-regulate the stemness property of breast cancer cells. Tregs increased the side-population and the ALDH(br) population of mouse breast cancer cells, promoted their sphere formation in a paracrine manner and enhanced the expression of stemness genes, such as Sox2 etc...
October 16, 2017: Stem Cells
Chih-Hung Chou, Basker Rajagopal, Chien-Fu Liang, Kuan-Lin Chen, Dun-Yuan Jin, Hsing-Yin Chen, Hsiu-Chung Tu, Yo-Ying Shen, Po-Chiao Lin
In this study, a series of variously substituted 2,3-dihydroquinolin-4-imines (DQIs) were synthesized from N-substituted propargylanilines by copper(I)-catalyzed annulation. The approach adopted in this study under mild, effective conditions exhibited broad substrate tolerance, particularly for functional groups substituted on anilines. Most of the DQI derivatives synthesized under optimal conditions were obtained in good isolated yields of 63-88%. 2,3-Dihydroquinolinimine thus obtained was easily converted to important structures like 2,3-dihydroquinolone and tetrahydrobenzodiazepin-5-one, confirming the importance of this strategy in constructing various heterocycles...
October 18, 2017: Chemistry: a European Journal
Isabelle Leguen
The general morphology and surface ultrastructure of the gills of adult and larvae medaka (Oryzias latipes) were studied in freshwater and seawater using scanning electron microscopy. The gills of all examined fish were structurally similar to those of other teleosts and consisted of four pairs of arches supporting (i) filaments bearing lamellae and (ii) rakers containing taste buds. Three cell types, specifically pavement cells, mitochondria-rich cells (MRCs), and mucous cells, constituted the surface layer of the gill epithelium...
October 17, 2017: Journal of Morphology
Jack W Rostas, Beunca D Graffree, Charles R Scoggins, Kelly M McMasters, Robert C G Martin
BACKGROUND: Anastomotic stricture following esophagogastrectomy (EG) can lead to significant dysphagia, necessitating interventions such as endoscopic dilatation. These post-operative complications gain importance with the increased survival rate of patients after EG. This study aimed to assess the outcomes of both circular-stapled (CS: 25 and 29 mm) and hand-sewn (HS) anastomoses after EG. METHODS: We reviewed prospectively accrued data from December 2004 to December 2014 identifying all patients undergoing EG for esophageal cancer...
October 16, 2017: Journal of Surgical Oncology
Maimuna S Majumder, John S Brownstein, Stan N Finkelstein, Richard C Larson, Lydia Bourouiba
Background: Nosocomial amplification resulted in nearly 200 cases of Middle East respiratory syndrome (MERS) during the 2015 South Korean MERS-coronavirus outbreak. It remains unclear whether certain types of cases were more likely to cause secondary infections than others, and if so, why. Methods: Publicly available demographic and transmission network data for all cases were collected from the Ministry of Health and Welfare. Statistical analyses were conducted to determine the relationship between demographic characteristics and the likelihood of human-to-human transmission...
June 1, 2017: Transactions of the Royal Society of Tropical Medicine and Hygiene
Tobias Schnitzer, Helma Wennemers
Trans/cis isomerization of Xaa-Pro bonds is key for the structure and function of several enzymes. In recent years, numerous versatile peptidic catalysts have been developed that bear Xaa-Pro amide bonds. Due to the many degrees of freedom within even short peptides, the design and optimization of peptidic catalysts by rational structural modifications is difficult. We envisioned that control over the trans/cis amide bond ratio may provide a tool to optimize the catalytic performance of peptidic catalysts. Here, we investigated the influence of the amide bond conformation on the stereoselectivity of H-Pro-Pro-Xaa-NH2-type peptidic catalysts in conjugate addition reactions...
October 18, 2017: Journal of the American Chemical Society
Chao Pan, Huan Liu, Jeffrey G Catalano, Ao Qian, Zimeng Wang, Daniel E Giammar
The reaction of manganese oxides with Cr(III)-bearing solids in soils and sediments can lead to the natural production of Cr(VI) in groundwater. Building on previous knowledge of MnO2 as an oxidant for Cr(III)-containing solids, this study systematically evaluated the rates and mechanisms of the oxidation of Cr(III) in iron oxides by δ-MnO2. The Fe/Cr ratio (x = 0.055-0.23 in CrxFe1-x(OH)3) and pH (5-9) greatly influenced the Cr(VI) production rates by controlling the solubility of Cr(III) in iron oxides. We established a quantitative relationship between Cr(VI) production rates and Cr(III) solubility of CrxFe1-x(OH)3, which can help predict Cr(VI) production rates at different conditions...
October 18, 2017: Environmental Science & Technology
Renata S Fernandes, Juliana O Silva, Samuel V Mussi, Sávia C A Lopes, Elaine A Leite, Geovanni D Cassali, Valbert N Cardoso, Danyelle M Townsend, Patrick M Colletti, Lucas A M Ferreira, Domenico Rubello, André L B de Barros
PURPOSE: Nanotheranostic platforms, i.e., the combination of both therapeutic and diagnostic agents on a single platform, are emerging as an interesting tool for the personalized cancer medicine. Therefore, the aim of this work was to evaluate the in vivo properties of a Tc-99m-labeled nanostructured lipid carrier (NLC) formulation, co-loaded with doxorubicin (DOX) and docosahexaenoic acid (DHA), for theranostic applications. PROCEDURES: NLC-DHA-DOX were prepared busing the hot melting homogenization method using an emulsification-ultrasound and were radiolabeled with Tc-99m...
October 17, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
I Sukhotnik, Y Ben Shahar, Y Pollak, T Dorfman, H Kreizman Shefer, Z E Assi, N Mor-Vaknin, A G Coran
PURPOSE: Intermediate filaments (IFs) are a part of the cytoskeleton that extend throughout the cytoplasm of all cells and function in the maintenance of cell-shape by bearing tension and serving as structural components of the nuclear lamina. In normal intestine, IFs provide a tissue-specific three-dimensional scaffolding with unique context-dependent organizational features. The purpose of this study was to evaluate the role of IFs during intestinal adaptation in a rat model of short bowel syndrome (SBS)...
October 17, 2017: Pediatric Surgery International
Jill P Smith, Shangzi Wang, Sandeep Nadella, Sandra A Jablonski, Louis M Weiner
Advanced pancreatic ductal adenocarcinoma (PDAC) has typically been resistant to chemotherapy and immunotherapy; therefore, novel strategies are needed to enhance therapeutic response. Cholecystokinin (CCK) has been shown to stimulate growth of pancreatic cancer. CCK receptors (CCKRs) are present on pancreatic cancer cells, fibroblasts, and lymphocytes. We hypothesized that CCKR blockade would improve response to immune checkpoint antibodies by promoting influx of tumor-infiltrating lymphocytes (TILs) and reducing fibrosis...
October 17, 2017: Cancer Immunology, Immunotherapy: CII
Steven Moerkerke, Volodymyr Malytskyi, Lionel Marcélis, Johan Wouters, Ivan Jabin
Artificial receptors able to recognize efficiently chemical species bearing a quaternary ammonium group have potential applications in the fields of biological and environmental analyses. A possible biomimetic strategy for the elaboration of such receptors consists of associating in close proximity a polyaromatic cavity with a polar binding site. Herein, we show that bis-calix[6]arene 1 behaves as a heteroditopic receptor that can bind biologically relevant quaternary ammonium ions and zwitterions. This host can selectively extract carbamylcholine G3 from water, opening the way for the sensing of this acetylcholine agonist...
October 18, 2017: Organic & Biomolecular Chemistry
Bérangère Godde, Abdelaziz Jouaiti, Audrey Fluck, Nathalie Kyritsakas, Matteo Mauro, Mir Wais Hosseini
The design and synthesis of a novel family of molecular turnstiles T1-T5 were achieved. All five turnstiles are based on a stator and a rotor covalently interconnected. While turnstiles T1-T2 are based on a symmetric stator equipped with two coordinating pyridyl units and a rotor bearing either a pyridyl or p-dimethylaminopyridyl coordinating moiety, the two non-symmetric turnstiles T4 and T5 are based on a stator bearing only a single pyridyl unit and the same rotor as T1 and T2 mentioned above. The switching between the open (T1-T5) and the closed (T-M) states of the turnstiles by metal cations (M = Ag(+) or Pd(2+)) was investigated in solution by using 1D and 2D NMR techniques...
October 18, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
Nasrin Rezaee, Alireza Salar, Fereshteh Ghaljaei, Naimeh Seyedfatem, Neda Rezaei
BACKGROUND: Contextual factors impact health the same way social and cultural conditions do. Women's health, with its varying dimensions, is also under the influence of biological, societal, and cultural contexts. This typical condition has been developed along the continuum of their life cycle, bearing close correlation with their lif style. Therefore, identifying those marices within which women's health behaviors are formed is important.This study aims at exploring the contextual factors affecting women's health in Sistan and Baluchestan in Iran...
October 2017: International Journal of Community Based Nursing and Midwifery
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