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https://www.readbyqxmd.com/read/28732430/bee-pollen-flavonoids-as-a-therapeutic-agent-in-allergic-and-immunological-disorders
#1
Masoomeh Jannesar, Maryam Sharif Shoushtari, Ahmad Majd, Zahra Pourpak
Bee pollen grains, as the male reproductive part of seed-bearing plants contain considerable concentrations of various phytochemicals and nutrients. Since antiquity, people throughout the world used pollens to cure colds, flu, ulcers, premature aging, anemia and colitis. It is now well-documented that some bee pollen secondary metabolites (e.g. flavonoid) may have positive health effects. In recent years, the flavonoids have attracted much interest because of their wide range of biological properties and their beneficial effects on human health...
June 2017: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/28732221/atrophic-mandible-fractures-are-bone-grafts-necessary-an-update
#2
Jaime Castro-Núñez, Larry L Cunningham, Joseph E Van Sickels
PURPOSE: The management of atrophic mandibular fractures poses a challenge because of anatomic variations and medical comorbidities associated with elderly patients. The purpose of this article is to review and update the literature regarding the management of atrophic mandible fractures using load-bearing reconstruction plates placed without bone grafts. MATERIALS AND METHODS: We performed a review of the English-language literature looking for atrophic mandibular fractures with or without continuity defects and reconstruction without bone grafts...
June 24, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28732218/invasiveness-of-tibial-bone-graft-harvesting-for-secondary-alveolar-bone-grafting-can-harvesting-be-made-at-the-age-of-less-than-10%C3%A2-years-without-complications
#3
Kohta Fukuta, Kenichi Kurita, Atsushi Nakayama, Masahito Maeda, Hiroshi Watanabe, Mitsuo Goto
PURPOSE: In this study, particulate cancellous bone marrow was harvested from the tibia for alveolar bone grafting, and postoperative complications at the donor site were compared between patients aged 10 years or older (29 tibias) and those aged younger than 10 years (42 tibias). PATIENTS AND METHODS: Enrolled patients were those who underwent tibial bone graft harvesting at the Department of Oral and Maxillofacial Surgery, Aichi Gakuin University, during a period of 3 years and 1 month from March 2012 through March 2015...
June 24, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28732155/relating-redox-properties-of-polyvinylamine-g-tempo-laccase-hydrogel-complexes-to-cellulose-oxidation
#4
Qiang Fu, Alexander Sutherland, Emil Gustafsson, Md Monsur Ali, Leyla Soleymani, Robert H Pelton
The structure and electrochemical properties of adsorbed complexes based on mixtures of polyvinylamine-g-TEMPO (PVAm-T) and laccase were related to the ability of the adsorbed complexes to oxidize cellulose. PVAm-T10 with 10% of the amines bearing TEMPO moieties (i.e. DS= 10%), adsorbed onto gold-sulfonate EQCM-D sensor surfaces giving a hydrogel film, 7 nm thick, 89% water and encasing laccase (200 mM) and TEMPO moieties (33 mM). For DS values >10% all of the TEMPOs in the hydrogel film were redox-active, in that they could be oxidized by the electrode...
July 21, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28731882/the-effect-on-bone-outcomes-of-home-based-exercise-intervention-for-prostate-cancer-survivors-receiving-androgen-deprivation-therapy-a-pilot-randomized-controlled-trial
#5
Soo Hyun Kim, Do Hwan Seong, Sang Min Yoon, Young Deuk Choi, Eunju Choi, Youngkyu Song, Hosook Song
BACKGROUND: Cancer treatment-induced bone loss has important long-term effects in prostate cancer survivors (PCSs) receiving androgen deprivation therapy (ADT), but little is known about preventive interventions. OBJECTIVE: The aim of this study was to examine the feasibility and preliminary effectiveness of a 6-month home-based exercise intervention in PCSs. METHODS: In this pilot, randomized controlled trial, 51 men (mean age, 70.8 years) were randomized to a 6-month home-based exercise intervention for preventing osteoporosis group (n = 26) or an exercise placebo intervention of stretching exercise group (n = 25)...
July 20, 2017: Cancer Nursing
https://www.readbyqxmd.com/read/28731817/infrared-spectrometer-for-exomars-a-mast-mounted-instrument-for-the-rover
#6
Oleg I Korablev, Yurii Dobrolensky, Nadezhda Evdokimova, Anna A Fedorova, Ruslan O Kuzmin, Sergei N Mantsevich, Edward A Cloutis, John Carter, Francois Poulet, Jessica Flahaut, Andrew Griffiths, Matthew Gunn, Nicole Schmitz, Javier Martín-Torres, Maria-Paz Zorzano, Daniil S Rodionov, Jorge L Vago, Alexander V Stepanov, Andrei Yu Titov, Nikita A Vyazovetsky, Alexander Yu Trokhimovskiy, Alexander G Sapgir, Yurii K Kalinnikov, Yurii S Ivanov, Alexei A Shapkin, Andrei Yu Ivanov
ISEM (Infrared Spectrometer for ExoMars) is a pencil-beam infrared spectrometer that will measure reflected solar radiation in the near infrared range for context assessment of the surface mineralogy in the vicinity of the ExoMars rover. The instrument will be accommodated on the mast of the rover and will be operated together with the panoramic camera (PanCam), high-resolution camera (HRC). ISEM will study the mineralogical and petrographic composition of the martian surface in the vicinity of the rover, and in combination with the other remote sensing instruments, it will aid in the selection of potential targets for close-up investigations and drilling sites...
June 2017: Astrobiology
https://www.readbyqxmd.com/read/28731716/the-inheritance-angle-a-determinant-for-the-number-of-members-in-the-substituted-cucurbit-n-uril-family
#7
Yi Zhao, Vijaybabu Mandadapu, Hasti Iranmanesh, Jonathon E Beves, Anthony I Day
Two new glycoluril diethers have been prepared, bearing strained cyclobutene and cyclobutane rings at the fused junction of the two imidazolidinone rings. The wide angle of the concave face of the cyclobutano derivative enabled the synthesis of cyclobutanocucurbit[5-8]uril, the largest member being the most significant achievement. A limited binding affinity study compared the new substituted family to classical cucurbit[5-8]uril. Surprisingly lower affinities were found, except for cyclobutanocucurbit[6]uril, which was 3...
July 21, 2017: Organic Letters
https://www.readbyqxmd.com/read/28731693/isolable-bis-triarylamine-dications-analogues-of-thiele-s-chichibabin-s-and-m%C3%A3-ller-s-hydrocarbons
#8
Gengwen Tan, Xinping Wang
Since the pioneering work by Thiele and Chichibabin, who synthesized the first diradicals bridged by phenylene and biphenylene groups in 1904 and 1907, respectively, numerous efforts have been devoted to synthesizing stable diradicals during the last few decades, and several strategies have been developed to stabilize these highly reactive diradicals. In this Account, we describe the synthesis and characterization of isolable bis(triarylamine) dications, nitrogen analogues of Thiele's, Chichibabin's, and Müller's hydrocarbons, which represent facilely accessible, stable diradicals by replacing carbinyl centers with isoelectronic aminium centers...
July 21, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28731681/the-first-n-borylated-emitters-displaying-highly-efficient-thermally-activated-delayed-fluorescence-and-high-performance-oleds
#9
Yi-Jyun Lien, Tzu-Chieh Lin, Chun-Chieh Yang, Yu-Cheng Chiang, Chih-Hao Chang, Shih-Hung Liu, Yi-Ting Chen, Gene-Hsiang Lee, Pi-Tai Chou, Chin-Wei Lu, Yun Chi
Despite the fast boom of thermally activated delayed fluorescence (TADF) emitters bearing borane-based acceptor, so far, none of TADF emitters with a direct B-N linkage between N-donor and boryl acceptor has been reported. The latter should simplify molecular architecture and hence facilitate the synthetic design and versatility. We report here the preparation and characterization of a new series of N-borylated compounds with functional acridine donor unit; namely: ACBM, PACBM and SACBM. Spectroscopic studies were performed to explore their photophysical properties that exhibited prominent solvatochromism and thermally activated delayed fluorescence...
July 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28731465/pr-set7-deficiency-limits-uterine-epithelial-population-growth-hampering-postnatal-gland-formation-in-mice
#10
Tongtong Cui, Bo He, Shuangbo Kong, Chan Zhou, Hangxiao Zhang, Zhangli Ni, Haili Bao, Jingtao Qiu, Qiliang Xin, Danny Reinberg, John P Lydon, Jinhua Lu, Haibin Wang
Formation of secretary endometrial glands in the uterus known as adenogenesis is a typical process of branching morphogenesis involving dynamic epithelial growth and differentiation. Unsuccessful adenogenesis often leads to female infertility. However, it remains largely unexplored so far regarding the epigenetic machinery governing normal endometrial gland formation. Here, we demonstrated that PR-Set7, an epigenetic regulator for H4K20me1 modification, was extensively expressed in the postnatal uteri, and its conditional deletion resulted in a complete lack of endometrial glands and infertility in mice...
July 21, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/28731361/the-impact-of-teaching-prognostication-at-the-end-of-life-a-pre-post-interventional-study
#11
Alexandria Bear, Tucker Keuter, Jayshil J Patel
BACKGROUND: Providing accurate and valid prognostic information significantly influences end-of-life care. Disclosing a poor prognosis can be among the most difficult of physician responsibilities, thus having appropriate knowledge during training is crucial for appropriate prognostication. OBJECTIVE: To provide internal medicine (IM) house staff with a pre- and posteducational survey to determine their ability to accurately prognosticate 5 common end-stage diseases...
January 1, 2017: American Journal of Hospice & Palliative Care
https://www.readbyqxmd.com/read/28731226/curcumin-converts-foxp3-regulatory-t-cells-to-t-helper-1-cells-in-patients-with-lung-cancer
#12
JianYong Zou, ChunHua Su, HongHe Luo, YiYan Lei, Bo Zeng, HaoShuai Zhu, ZhenGuang Chen
The regulatory T cells (Treg) play an important role in the tumor tolerance. The methods to regulate the Treg population in cancer-bearing hosts are limited currently. The effect of curcumin on inhibiting cancer has been recognized, but the mechanism remains elusive. This study tests a hypothesis that administration of curcumin down regulates Tregs in lung cancer (LC) patients. In this study, a group of LC patients was treated with curcumin. The peripheral Tregs and T helper (Th) 1 cells were analyzed by flow cytometry...
July 21, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28730956/review-on-bioorganometallic-chemistry-and-new-outcomes-in-the-synthesis-and-substitution-of-tetracarbonyl-pyrrolylimine-complexes-of-rhenium-with-organophosphorus-ligands
#13
Antoine Simonneau, Franck Le Bideau, Jean-Hugues Mirebeau, Jérôme Marrot, Gérard Jaouen
: After a short review dealing with bioorganometallic chemistry, the synthesis of tetracarbonyl (pyrrolylimine) complexes of rhenium bearing chirality on the pyrrolyl ligands was reported.The reactivity of these compounds towards the substitution of one carbonyl ligand with triphenyl phosphine, tricyclohexyl phosphine and trimethyl phosphite was studied. The rhenium becoming a stereogenic center in that transformation, the resulting tricarbonyl species were obtained as mixtures of diastereomers, with diastereomeric excesses varying from 8 to 84%, according to the reaction conditions and the relative steric hindrances of the pyrrolylimine and the organophosphorus ligands...
July 19, 2017: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/28730820/tryptic-peptides-bearing-c-terminal-dimethyllysine-need-be-considered-during-the-analysis-of-lysine-dimethylation-in-proteomic-study
#14
Ming Chen, Min Zhang, Linhui Zhai, Hao Hu, Ping Liu, Minjia Tan
Lysine methylation plays important roles in structural and functional regulation of chromatin. Although trypsin is the most widely used protease in mass spectrometry-based proteomic analysis for lysine methylation substrates, the proteolytic activity of trypsin on dimethylated lysine residues remains an arguable issue. In this study, we tested the ability of trypsin to cleave dimethylated lysine residues in synthetic peptides, purified albumin and whole cell lysate, and found that the C-terminal of dimethylated lysine residue could be cleaved in a protein sequence-dependent manner...
July 21, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28730439/design-and-preparation-of-aptamer-sirna-chimeras-asics-for-targeted-cancer-therapy
#15
Sven Kruspe, Paloma H Giangrande
Conjugation of cell-internalizing DNA or RNA aptamers to tumor-suppressing siRNAs represents a novel promising approach for cancer therapy. Here we describe how to employ RNA aptamers that bind to cell surface receptors as carriers for cell-targeted siRNA (or miRNA) delivery. This protocol was optimized to improve the efficiency of the aptamer-siRNA/miRNA conjugates and facilitate its implementation in most molecular biology labs. The single working steps include (1) outlining the optimal sequences of the RNA strands bearing the aptamer and siRNA sequence, for which further (2) a dsDNA template is synthesized and then (3) transcribed into an RNA that will be (4) folded and annealed to a chemically synthesized siRNA complementary strand...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28730344/bearing-fruit-flower-removal-reveals-the-trade-offs-associated-with-high-reproductive-effort-for-lowbush-blueberry
#16
Alex W Bajcz, Francis A Drummond
Past studies have shown that taxa from disparate groups often respond similarly to reduced reproductive effort. These common responses imply that high reproductive effort trades off with a consistent set of other life functions for most angiosperms, albeit modulated by their growth form and life history. However, many questions remain about reproductive trade-offs in plants, including just how many other life functions they involve, how diverse these functions may be, and how the severity of these trade-offs may vary through time...
July 20, 2017: Oecologia
https://www.readbyqxmd.com/read/28730193/using-anion-recognition-to-control-the-folding-and-unfolding-of-a-single-chain-phosphorescent-polymer
#17
Xiaofan Ji, Chenxing Guo, Xian-Sheng Ke, Xiaodong Chi, Jonathan L Sessler
We report here the use of anion recognition to control the folding and unfolding of a single polymeric chain consisting of a PMMA bearing pendant calix[4]pyrrole and Pt(ii) porphyrin subunits.
July 21, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28730192/first-stereoselective-total-synthesis-of-brevipolide-m
#18
Kasa Shiva Raju, Gowravaram Sabitha
The first stereoselective total synthesis of a cytotoxic brevipolide M, which shares a pyrone framework bearing a tetrahydrofuran moiety and a cinnamate group with the readily available (-)-DET, is described. The key steps involved in the synthesis are the epoxide-opening, Brown's allylation, and the RCM reaction to install an α,β-unsaturated lactone ring and the inversion of the C-6' stereogenic hydroxyl group using the Mitsunobu reaction.
July 21, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28729643/superhydrophobic-drag-reduction-spherical-bearing-fabricated-by-laser-ablation-and-pei-regulated-zno-nanowire-growth
#19
Rui Weng, Haifeng Zhang, Yanjing Tuo, Yang Wang, Xiaowei Liu
The resistance of the bearing is a significant factor affecting the performance of the ball-disk rotor gyroscope. The micro and nano combined surface with low surface energy material modifications can be hydrophobic. This can reduce the drag when the bearing is lubricated by deionized water. Laser ablation method is utilized to form micron-scaled structures on the surface of the stainless steel rotor ball. And the nanostructures are formed by PEI (Polyetherimide) regulated ZnO nanowires growth. After low surface energy material modification, the water contact angle of processed surface was 163° and the sliding angle was less than 4°...
July 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28729631/therapeutic-effects-of-long-circulating-mir-135a-containing-cationic-immunoliposomes-against-gallbladder-carcinoma
#20
Guanghua Yang, Baobing Yin
Gallbladder carcinoma (GBC) is the most common malignant tumour in the biliary tract, but effective therapeutics are lacking. Based on our previous studies, miR-135a is a potential tool to inhibit GBC proliferation. In this study, we constructed miR-135a-loaded DSPE-PEG2000 liposomes modified with Anti-EGFR antibodies (Anti-EGFR-CIL-miR-135a). The results of an analysis of their physicochemical properties indicated the particle size of it was 222.0 ± 2.1 nm in diameter with an uptake efficiency of 86...
July 20, 2017: Scientific Reports
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