Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#21
MULTICENTER STUDY
Bradley S Marino, Amy Cassedy, Katherine L Brown, Rodney Franklin, J William Gaynor, Mirjana Cvetkovic, Simon Laker, Katherine Levinson, Helen MacGloin, Lynn Mahony, Annette McQuillan, Kathleen Mussatto, Deirdre O'Shea, Jane Newburger, Michelle Sykes, Sarah A Teele, Gil Wernovsky, Jo Wray
OBJECTIVES: Greater congenital heart disease (CHD) complexity is associated with lower health-related quality of life (HRQOL). There are no data on the association between surgical and ICU factors and HRQOL in CHD survivors. This study assess the association between surgical and ICU factors and HRQOL in child and adolescent CHD survivors. DESIGN: This was a corollary study of the Pediatric Cardiac Quality of Life Inventory (PCQLI) Testing Study. SETTING: Eight pediatric hospitals participating in the PCQLI Study...
May 1, 2023: Pediatric Critical Care Medicine
#22
JOURNAL ARTICLE
Daniel J Licht, Marin Jacobwitz, Jennifer M Lynch, Tiffany Ko, Timothy Boorady, Mahima Devarajan, Kristina N Heye, Kobina Mensah-Brown, John J Newland, Alexander Schmidt, Peter Schwab, Madeline Winters, Susan C Nicolson, Lisa M Montenegro, Stephanie Fuller, Christopher Mascio, J William Gaynor, Arjun G Yodh, Juliana Gebb, Arastoo Vossough, Grace H Choi, Mary E Putt
Background Infants with congenital heart disease (CHD) are at risk for white matter injury (WMI) before neonatal heart surgery. Better knowledge of the causes of preoperative WMI may provide insights into interventions that improve neurodevelopmental outcomes in these patients. Methods and Results A prospective single-center study of preoperative WMI in neonates with CHD recorded data on primary cardiac diagnosis, maternal-fetal environment (MFE), delivery type, subject anthropometrics, and preoperative care...
April 4, 2023: Journal of the American Heart Association
#23
JOURNAL ARTICLE
Shabnam Peyvandi, Duan Xu, A James Barkovich, Dawn Gano, Vann Chau, V Mohan Reddy, Thiviya Selvanathan, Ting Guo, J William Gaynor, Mike Seed, Steven P Miller, Patrick McQuillen
BACKGROUND: Brain injury is common in neonates with complex neonatal congenital heart disease (CHD) and affects neurodevelopmental outcomes. OBJECTIVES: Given advancements in perioperative care, we sought to determine if the rate of preoperative and postoperative brain injury detected by using brain magnetic resonance imaging (MRI) and associated clinical risk factors have changed over time in complex CHD. METHODS: A total of 270 term newborns with complex CHD were prospectively enrolled for preoperative and postoperative brain MRIs between 2001 and 2021 with a total of 466 MRI scans...
January 24, 2023: Journal of the American College of Cardiology
#24
JOURNAL ARTICLE
S Ram Kumar, J William Gaynor, Leigh Ann Jones, Carole Krohn, John E Mayer, Meena Nathan, James E O'Brien, Christian Pizarro, Chasity Wellnitz, Jennifer S Nelson
The Society of Thoracic Surgeons (STS) Congenital Heart Surgery Database continues to be one of the most comprehensive clinical outcomes registries capturing almost all pediatric cardiothoracic surgical operations undertaken in the United States. The latest analysis of aggregate outcomes was performed after the 33rd data harvest and included congenital and pediatric cardiac operations performed between July 1, 2017 and June 30, 2021. This article summarizes these contemporary outcomes and provides a context for the interpretation of these outcomes...
April 2023: Annals of Thoracic Surgery
#25
JOURNAL ARTICLE
Meena Nathan, Jane W Newburger, Margaret Bell, Alexander Tang, Russell Gongwer, Carolyn Dunbar-Masterson, Andrew M Atz, Emile Bacha, Steven Colan, J William Gaynor, Kirk Kanter, Jami C Levine, Richard Ohye, Christian Pizarro, Steven Schwartz, Girish Shirali, Lloyd Tani, James Tweddell, Michelle Gurvitz
BACKGROUND AND OBJECTIVE: The Residual Lesion Score is a novel tool for assessing the achievement of surgical objectives in congenital heart surgery based on widely available clinical and echocardiographic characteristics. This article describes the methodology used to develop the Residual Lesion Score from the previously developed Technical Performance Score for five common congenital cardiac procedures using the RAND Delphi methodology. METHODS: A panel of 11 experts from the field of paediatric and congenital cardiology and cardiac surgery, 2 co-chairs, and a consultant were assembled to review and comment on validity and feasibility of measuring the sub-components of intraoperative and discharge Residual Lesion Score for five congenital cardiac procedures...
December 23, 2022: Cardiology in the Young
#26
JOURNAL ARTICLE
J William Gaynor, Nancy B Burnham, Richard F Ittenbach, Marsha Gerdes, Judy C Bernbaum, Elaine Zackai, Daniel J Licht, William W Russell, Erin E Zullo, Thomas Miller, Hakon Hakonarson, Kayan A Clarke, Gail P Jarvik, Antonia M Calafat, Asa Bradman, David C Bellinger, Frederick M Henretig, Eric S Coker
BACKGROUND: Children with congenital heart defects have an increased risk of neurodevelopmental disability. The impact of environmental chemical exposures during daily life on neurodevelopmental outcomes in toddlers with congenital heart defects is unknown. METHODS: This prospective study investigated the impacts of early childhood exposure to mixtures of environmental chemicals on neurodevelopmental outcomes after cardiac surgery. Outcomes were assessed at 18 months of age using The Bayley Scales of Infant and Toddler Development-III...
2022: PloS One
#27
REVIEW
Cathy Breen, Jean O'Connell, Justin Geoghegan, Donal O'Shea, Susie Birney, Louise Tully, Karen Gaynor, Mark O'Kelly, Grace O'Malley, Clare O'Donovan, Oonagh Lyons, Mary Flynn, Suzanne Allen, Niamh Arthurs, Sarah Browne, Molly Byrne, Shauna Callaghan, Chris Collins, Aoife Courtney, Michael Crotty, Ciara Donohue, Caroline Donovan, Colin Dunlevy, Diarmuid Duggan, Naomi Fearon, Francis Finucane, Ita Fitzgerald, Siobhan Foy, John Garvey, Irene Gibson, Liam Glynn, Edward Gregg, Anne Griffin, Janas M Harrington, Caroline Heary, Helen Heneghan, Andrew Hogan, Mary Hynes, Claire Kearney, Dervla Kelly, Karl Neff, Carel W le Roux, Sean Manning, Fionnuala McAuliffe, Susan Moore, Niamh Moran, Maura Murphy, Celine Murrin, Sarah M O'Brien, Caitríona O'Donnell, Sarah O'Dwyer, Cara O'Grada, Emer O'Malley, Orlaith O'Reilly, Sharleen O'Reilly, Olivia Porter, Helen M Roche, Amanda Rhynehart, Leona Ryan, Suzanne Seery, Corina Soare, Ferrah Shaamile, Abigail Walsh, Catherine Woods, Conor Woods, Ruth Yoder
BACKGROUND: This Clinical Practice Guideline (CPG) for the management of obesity in adults in Ireland, adapted from the Canadian CPG, defines obesity as a complex chronic disease characterised by excess or dysfunctional adiposity that impairs health. The guideline reflects substantial advances in the understanding of the determinants, pathophysiology, assessment, and treatment of obesity. SUMMARY: It shifts the focus of obesity management toward improving patient-centred health outcomes, functional outcomes, and social and economic participation, rather than weight loss alone...
October 24, 2022: Obesity Facts
#28
JOURNAL ARTICLE
Tiffany S Ko, Constantine D Mavroudis, Emilie J Benson, Rodrigo M Forti, Richard W Melchior, Timothy W Boorady, Vincent C Morano, Kobina Mensah-Brown, Yuxi Lin, Danielle Aronowitz, Jonathan P Starr, Tami M Rosenthal, Brandon C Shade, Kellie L Schiavo, Brian R White, Jennifer M Lynch, J William Gaynor, Daniel J Licht, Arjun G Yodh, Wesley B Baker, Todd J Kilbaugh
Neonates undergoing cardiac surgery involving aortic arch reconstruction are at an increased risk for hypoxic-ischemic brain injury. Deep hypothermia is utilized to help mitigate this risk when periods of circulatory arrest are needed for surgical repair. Here, we investigate correlations between non-invasive optical neuromonitoring of cerebral hemodynamics, which has recently shown promise for the prediction of postoperative white matter injury in this patient population, and invasive cerebral microdialysis biomarkers...
August 10, 2022: Metabolites
#29
JOURNAL ARTICLE
James K Moon, Kendall M Lawrence, Mallory L Hunt, Marcus G Davey, Alan W Flake, Daniel J Licht, Jonathan M Chen, Todd J Kilbaugh, J William Gaynor, Daniel P Beiting
Objective: The molecular pathways underlying hypoxemia-induced alterations in neurodevelopment of infants with congenital heart disease have not been delineated. We used transcriptome analysis to investigate differential gene expression induced by hypoxemia in an ovine artificial-womb model. Methods: Mid-gestation fetal sheep (median [interquartile range] 109 [107-112] days' gestation) were cannulated via the umbilical vessels, attached to a pumpless, low-resistance oxygenator circuit, and incubated in a sterile, fluid environment for 22 [21-23] days...
June 2022: JTCVS open
#30
JOURNAL ARTICLE
Jeffrey Phillip Jacobs, S Ram Kumar, James D St Louis, Zohair Y Al-Halees, Robert H Habib, Niharika Parsons, Kevin D Hill, Sara K Pasquali, J William Gaynor, Christopher E Mascio, David M Overman, Joseph A Dearani, John E Mayer, David M Shahian, Marshall L Jacobs
BACKGROUND: The Society of Thoracic Surgeons Congenital Heart Surgery Database (STS-CHSD) was queried to document variation of patient characteristics, procedure types, and programmatic case-mix. METHODS: All index cardiac operations in patients <18 years in STS-CHSD (July 2016 to June 2020) were eligible for inclusion except patients <2.5 kilograms undergoing isolated PDA closure. At the hospital level, we describe variation in patient and procedural characteristics that are known from previous analyses to be associated with outcomes...
August 5, 2022: Annals of Thoracic Surgery
#31
JOURNAL ARTICLE
Danielle I Aronowitz, Tracy R Geoffrion, Danielle Burstein, Rachel M White, Sara McHugh-Grant, Constantine D Mavroudis, Muhammad A K Nuri, Katsuhide Maeda, Jonathan M Chen, Christopher E Mascio, J William Gaynor, Stephanie Fuller
BACKGROUND: Children undergoing orthotopic heart transplantation (OHT) may require complex reconstruction of superior vena cava (SVC) anomalies. SVC anatomy and mode of reconstruction are potential risk factors for SVC obstruction. METHODS: Retrospective single-center review of patients undergoing initial OHT between 1/1/1990-7/1/2021. "Simple" SVC anatomy included a single right SVC to the right atrium or bilateral SVCs with a left SVC to an intact coronary sinus, without prior superior cavopulmonary connection...
August 4, 2022: Annals of Thoracic Surgery
#32
JOURNAL ARTICLE
Laura Horodyski, Javier Gonzalez, Marina M Tabbara, Jeffrey J Gaynor, Maria Rodriguez-Cabero, Felipe Herranz-Amo, Carlos Hernández, Rushi Shah, Gaetano Ciancio
Introduction: It has been suggested that inferior vena cava (IVC) reconstruction following resection of retroperitoneal tumors with IVC tumor thrombus (TT) is not required when adequate collateral circulation is present. There are no reports evaluating mid-term effects on renal function in these patients. The purpose of this study was to assess renal function after en bloc resection of right renal cell carcinoma (RCC) with obstructing IVC TT and the possible risks that may arise after left renal vein division...
2022: Frontiers in Oncology
#33
JOURNAL ARTICLE
Andrew H Smith, Andrew Y Shin, Sarah Tabbutt, Mousumi Banerjee, Wenying Zhang, Santiago Borasino, Justin J Elhoff, J William Gaynor, Nancy S Ghanayem, Sara K Pasquali, James D St Louis, Subhadra Shashidharan, Michael Ruppe, Kurt R Schumacher, Michael Gaies, John M Costello
OBJECTIVE: The optimal timing for neonatal cardiac surgery is a potentially modifiable factor that may affect outcomes. We studied the relationship between age at surgery (AAS) and outcomes across multiple hospitals, focusing on neonatal operations where timing appears is not emergency. METHODS: We studied neonates ≥37 weeks' gestation and ≥2.5 kg admitted to a treating hospital on or before day of life 2 undergoing selected index cardiac operations...
April 2023: Journal of Thoracic and Cardiovascular Surgery
#34
JOURNAL ARTICLE
Martina A Steurer, Kurt Schuhmacher, Jill J Savla, Mousumi Banerjee, Nikhil K Chanani, Aaron Eckhauser, Justin Elhoff, Jeffrey P Jacobs, Katherine Mikesell, Shabnam Peyvandi, Jennifer Romano, Wenying Zhang, J William Gaynor, Sarah Tabbutt
OBJECTIVE: Current risk adjustment models for congenital heart surgery do not fully incorporate multiple factors unique to neonates such as granular gestational age (GA) and birth weight (BW) z score data. This study sought to develop a Neonatal Risk Adjustment Model for congenital heart surgery to address these deficiencies. METHODS: Cohort study of neonates undergoing cardiothoracic surgery during the neonatal period captured in the Pediatric Cardiac Critical Care Consortium database between 2014 and 2020...
May 28, 2022: Journal of Thoracic and Cardiovascular Surgery
#35
JOURNAL ARTICLE
Monique M Gardner, Garrett Keim, Jill Hsia, Anh D Mai, J William Gaynor, Andrew C Glatz, Nadir Yehya
Background Neonates with heart disease requiring cardiopulmonary bypass surgery are at high risk for mortality and morbidity. As it is rare, short-term mortality is difficult to use as a primary outcome for clinical studies. We proposed "ICU-30" as a binary composite "poor" outcome consisting of: (1) mortality within 30 days, (2) intensive care unit (ICU) admission ≥30 days, or (3) ICU readmission before day 30. To measure the utility of this composite, we assessed its prognostic properties for 6- and 12-month mortality...
June 21, 2022: Journal of the American Heart Association
#36
JOURNAL ARTICLE
Amrita Sukhavasi, Sara McHugh-Grant, Andrew C Glatz, Antara Mondal, Heather Griffis, Nancy Burnham, Jonathan M Chen, Christopher E Mascio, J William Gaynor, Thomas L Spray, Stephanie M Fuller
OBJECTIVE: Neonatal interventional strategies for pulmonary atresia with intact ventricular septum are based on tricuspid valve hypoplasia and right ventricle-dependent coronary circulation. We sought to evaluate long-term outcomes comparing biventricular (BiV) versus single-ventricle (SV) strategies. METHODS: Retrospective review was performed of 119 patients diagnosed with pulmonary atresia with intact ventricular septum from 1995 to 2018. Descriptive statistics summarized patient characteristics and a multivariable Cox survival model was used to compare treatment strategies...
November 2022: Journal of Thoracic and Cardiovascular Surgery
#37
JOURNAL ARTICLE
Sharon-Lise T Normand, Katya Zelevinsky, Meena Nathan, Haley K Abing, Joseph A Dearani, Mark Galantowicz, J William Gaynor, Robert H Habib, Frank L Hanley, Jeffrey P Jacobs, S Ram Kumar, Donna E McDonald, Sara K Pasquali, David M Shahian, James S Tweddell, David F Vener, John E Mayer
BACKGROUND: The Society of Thoracic Surgeons' Congenital Heart Surgery Database (STS CHSD) provides risk-adjusted operative mortality rates to approximately 120 North American congenital heart centers. Optimal case-mix adjustment methods for operative mortality risk prediction in this population remain unclear. METHODS: A panel created diagnosis-procedure (D-P) combinations of encounters in the CHSD. Models for operative mortality using the new D-P categories, procedure-specific risk factors, and syndromes/abnormalities included in the CHSD were estimated using Bayesian additive regression trees (BART) and lasso models...
February 2, 2022: Annals of Thoracic Surgery
#38
JOURNAL ARTICLE
Sharon-Lise T Normand, Katya Zelevinsky, Meena Nathan, Haley K Abing, Joseph A Dearani, Mark Galantowicz, J William Gaynor, Robert H Habib, Frank L Hanley, Jeffrey P Jacobs, S Ram Kumar, Donna E McDonald, Sara K Pasquali, David M Shahian, James S Tweddell, David F Vener, John E Mayer
BACKGROUND: The Society of Thoracic Surgeons' Congenital Heart Surgery Database provides observed to expected (O/E) operative mortality ratios to more than 100 congenital heart centers in North America. We compared the current approach (STS-CHSD) for estimating O/E ratios to approaches incorporating information on diagnosis as moderators of procedures, other unutilized risk factors, and additional variation in confidence interval (CI) construction to characterize center performance. METHODS: Bayesian additive regression trees (BART) and lasso models linked operative mortality to diagnosis-procedure categories, procedure-specific risk factors, and syndromes/abnormalities...
February 1, 2022: Annals of Thoracic Surgery
#39
JOURNAL ARTICLE
Jill J Savla, Mary E Putt, Jing Huang, Samuel Parry, Julie S Moldenhauer, Samantha Reilly, Olivia Youman, Jack Rychik, Laura Mercer-Rosa, J William Gaynor, Steven M Kawut
BACKGROUND Children with single ventricle heart disease have significant morbidity and mortality. The maternal-fetal environment (MFE) may adversely impact outcomes after neonatal cardiac surgery. We hypothesized that impaired MFE would be associated with an increased risk of death after stage 1 Norwood reconstruction. METHODS AND RESULTS We performed a retrospective cohort study of children with hypoplastic left heart syndrome (and anatomic variants) who underwent stage 1 Norwood reconstruction between 2008 and 2018...
January 18, 2022: Journal of the American Heart Association
#40
JOURNAL ARTICLE
Victor M Ruiz, Michael P Goldsmith, Lingyun Shi, Allan F Simpao, Jorge A Gálvez, Maryam Y Naim, Vinay Nadkarni, J William Gaynor, Fuchiang Rich Tsui
OBJECTIVES: To develop and evaluate a high-dimensional, data-driven model to identify patients at high risk of clinical deterioration from routinely collected electronic health record (EHR) data. MATERIALS AND METHODS: In this single-center, retrospective cohort study, 488 patients with single-ventricle and shunt-dependent congenital heart disease <6 months old were admitted to the cardiac intensive care unit before stage 2 palliation between 2014 and 2019. Using machine-learning techniques, we developed the Intensive care Warning Index (I-WIN), which systematically assessed 1028 regularly collected EHR variables (vital signs, medications, laboratory tests, and diagnoses) to identify patients in the cardiac intensive care unit at elevated risk of clinical deterioration...
July 2022: Journal of Thoracic and Cardiovascular Surgery
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
