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https://www.readbyqxmd.com/read/29666946/pharmaceutical-products-as-emerging-contaminant-in-water-relevance-for-developing-nations-and-identification-of-critical-compounds-for-indian-environment
#1
Prakash Chinnaiyan, Santosh G Thampi, Mathava Kumar, K M Mini
Pharmaceuticals and personal care products (PPCPs) are contaminants of emerging concern and have been detected worldwide in water bodies in trace concentrations. Most of these emerging contaminants are not regulated in water quality standards except a few in the developed countries. In the case of developing countries, research in this direction is at a nascent stage. For the effective management of Pharmaceutical contaminants (PC) in developing countries, the relevance of PCs as an emerging contaminant has to be analyzed followed by regular monitoring of the environment...
April 17, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29666832/structure-and-function-analysis-in-circulating-tumor-cells-using-nanotechnology-to-study-nuclear-size-in-prostate-cancer
#2
REVIEW
Nu Yao, Yu-Jen Jan, Shirley Cheng, Jie-Fu Chen, Leland Wk Chung, Hsian-Rong Tseng, Edwin M Posadas
Professor Donald Coffey and his laboratory pioneered studies showing the relationships between nuclear shape and cellular function. In doing so, he and his students established the field of nuclear morphometry in prostate cancer. By using perioperative tissues via biopsies and surgical sampling, Dr. Coffey's team discovered that nuclear shape and other pathologic features correlated with clinical outcome measures. Cancer cells also exist outside of solid tumor masses as they can be shed from both primary and metastatic lesions into the circulatory system...
2018: American Journal of Clinical and Experimental Urology
https://www.readbyqxmd.com/read/29666812/tumor-progression-the-neuronal-input
#3
REVIEW
Marco Arese, Federico Bussolino, Margherita Pergolizzi, Laura Bizzozero, Davide Pascal
One of the challenges of cancer is its heterogeneity and rapid capacity to adapt. Notwithstanding significant progress in the last decades in genomics and precision medicine, new molecular targets and therapies appear highly necessary. One way to approach this complex problem is to consider cancer in the context of its cellular and molecular microenvironment, which includes nerves. The peripheral nerves, the topic of this review, modulate the biological behavior of the cancer cells and influence tumor progression, including the events related to the metastatic spread of the disease...
March 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29666045/general-practitioners-perspective-on-ehealth-and-lifestyle-change-qualitative-interview-study
#4
Carl Joakim Brandt, Gabrielle Isidora Søgaard, Jane Clemensen, Jens Sndergaard, Jesper Bo Nielsen
BACKGROUND: Wearables, fitness apps, and patient home monitoring devices are used increasingly by patients and other individuals with lifestyle challenges. All Danish general practitioners (GPs) use digital health records and electronic health (eHealth) consultations on a daily basis, but how they perceive the increasing demand for lifestyle advice and whether they see eHealth as part of their lifestyle support should be explored further. OBJECTIVE: This study aimed to explore GPs' perspectives on eHealth devices and apps and the use of eHealth in supporting healthy lifestyle behavior for their patients and themselves...
April 17, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29665979/crosstalk-between-yap-taz-and-notch-signaling
#5
REVIEW
Antonio Totaro, Martina Castellan, Daniele Di Biagio, Stefano Piccolo
How the behavior of cells in living tissues is orchestrated according to tissue needs, size, and developmental stage is still poorly understood. Advances in these directions are essential to understand morphogenesis, 'self-organization' phenomena, to build new tissues for regenerative medicine or to reverse the changes in deranged organs, such as in cancer or in genetic disorders. This review outlines a new scenario by which the crosstalk between the Yes-associated protein/transcriptional coactivator with PDZ-binding motif (YAP/TAZ) transcription factors and Notch signaling influences cell self-renewal, stem cell differentiation, cell fate decisions, epithelial-stromal interactions, inflammation, morphogenesis, and large-scale gene oscillations...
April 14, 2018: Trends in Cell Biology
https://www.readbyqxmd.com/read/29665454/comparison-of-the-mechanobiological-performance-of-bone-tissue-scaffolds-based-on-different-unit-cell-geometries
#6
Óscar L Rodríguez-Montaño, Carlos Julio Cortés-Rodríguez, Antonio E Uva, Michele Fiorentino, Michele Gattullo, Giuseppe Monno, Antonio Boccaccio
Enhancing the performance of scaffolds for bone regeneration requires a multidisciplinary approach involving competences in the fields of Biology, Medicine and Engineering. A number of studies have been conducted to investigate the influence of scaffolds design parameters on their mechanical and biological response. The possibilities offered by the additive manufacturing techniques to fabricate sophisticated and very complex microgeometries that until few years ago were just a geometrical abstraction, led many researchers to design scaffolds made from different unit cell geometries...
April 11, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29664124/a-comparison-of-the-treatment-recommendations-for-neurogenic-lower-urinary-tract-dysfunction-in-the-national-institute-for-health-and-care-excellence-european-association-of-urology-and-international-consultations-on-incontinence-guidelines
#7
Ashley Jaggi, Marcus Drake, Emad Siddiqui, Francis Fatoye
AIMS: Healthcare guidelines are an important vehicle in establishing up-to-date evidence based medicine (EBM) in clinical practice. Due to varying development processes, clinical guidelines created by different institutions can often contain contrasting recommendations. This can have implications for optimal and standardized patient care across management settings. METHODS: The similarities and differences of treatment recommendations made in the National Institute for Health and Care Excellence (NICE), The European Association of Urology (EAU), and the International Consultation on Continence (ICI) guidelines for neurogenic lower urinary tract dysfunction (NLUTD) were assessed...
April 17, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29663742/degenerative-effect-of-ankaferd-blood-stopper%C3%A2-on-mice-peripheral-sensory-neurons-in-vitro
#8
Ramazan Üstün, Elif Kaval Oğuz
Ankaferd Blood Stopper® (ABS) is a licensed medicinal herbal extract that ensures effective hemostasis on external, internal, postoperative and dental bleeds. Dorsal root ganglia (DRG) harbor cell bodies of peripheral sensory neurons. DRG neurons receive peripheral information and regularly send projections to nuclei in the brainstem and the spinal cord. These neurons play critical roles in neural development. Neuronal dysfunctions were reported due to ABS use in surgical interventions. The purpose of this experiment was to investigate the degenerative effects of the ABS on mice DRG cells <I>in vitro</I>...
2018: Folia Neuropathologica
https://www.readbyqxmd.com/read/29659694/nutritional-genomics-and-direct-to-consumer-genetic-testing-an-overview
#9
Marta Guasch-Ferré, Hassan S Dashti, Jordi Merino
The increasing prevalence in polygenic diseases, such as obesity, cardiovascular disease, and type 2 diabetes, observed over the past few decades is more likely linked to a rapid transition in lifestyle rather than to changes in the sequence of the nuclear genome. In the new era of precision medicine, nutritional genomics holds the promise to be translated into tailored nutritional strategies to prevent and manage polygenic diseases more effectively. Nutritional genomics aims to prevent, treat, and manage polygenic diseases through targeted therapies formulated from individuals' genetic makeup and dietary intake...
March 1, 2018: Advances in Nutrition
https://www.readbyqxmd.com/read/29659306/physical-activity-levels-and-self-determined-motivation-among-future-healthcare-professionals-utility-of-the-behavioral-regulation-in-exercise-questionnaire-breq-2
#10
Rebecca Mahony, Catherine Blake, James Matthews, Grainne O' Donnoghue, Caitriona Cunningham
BACKGROUND: Healthcare professionals (HCPs) who are physically active are regarded as more likely to act as credible physical activity (PA) role models and promote healthy lifestyles. This study explores PA levels and underlying motivations, within and between HCP students, first testing the validity and reliability of the Behavioral Regulation in Exercise Questionnaire (BREQ-2). METHODS: The International Physical Activity Questionnaire (IPAQ) and BREQ-2 were administered to 296 HCP university students (physiotherapy n = 47, medicine n = 105, nursing n = 121, radiography n = 23)...
April 16, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29657963/hologenomics-systems-level-host-biology
#11
Kevin R Theis
The hologenome concept of evolution is a hypothesis explaining host evolution in the context of the host microbiomes. As a hypothesis, it needs to be evaluated, especially with respect to the extent of fidelity of transgenerational coassociation of host and microbial lineages and the relative fitness consequences of repeated associations within natural holobiont populations. Behavioral ecologists are in a prime position to test these predictions because they typically focus on animal phenotypes that are quantifiable, conduct studies over multiple generations within natural animal populations, and collect metadata on genetic relatedness and relative reproductive success within these populations...
March 2018: MSystems
https://www.readbyqxmd.com/read/29657092/the-critical-chemical-and-mechanical-regulation-of-folic-acid-on-neural-engineering
#12
Gloria B Kim, Yongjie Chen, Weibo Kang, Jinshan Guo, Russell Payne, Hui Li, Qiong Wei, Julianne Baker, Cheng Dong, Sulin Zhang, Pak Kin Wong, Elias B Rizk, Jiazhi Yan, Jian Yang
The mandate of folic acid supplementation in grained products has reduced the occurrence of neural tube defects by one third in the U.S since its introduction by the Food and Drug Administration in 1998. However, the advantages and possible mechanisms of action of using folic acid for peripheral nerve engineering and neurological diseases still remain largely elusive. Herein, folic acid is described as an inexpensive and multifunctional niche component that modulates behaviors in different cells in the nervous system...
April 3, 2018: Biomaterials
https://www.readbyqxmd.com/read/29655685/polygonum-aviculare-l-extract-reduces-fatigue-by-inhibiting-neuroinflammation-in-restraint-stressed-mice
#13
Sun Haeng Park, Seol Jang, Eunjung Son, Si Woo Lee, Sun Dong Park, Yoon-Young Sung, Ho Kyoung Kim
BACKGROUND: Chronic fatigue patients experience various neuropsychological symptoms, including fatigue behaviors, chronic pain, and depression. They also display immune system dysregulation. Polygonum aviculare L. extract (PAE) is a traditional herbal medicine used to treat inflammatory diseases by reportedly decreasing pro-inflammatory cytokine production. HYPOTHESIS/PURPOSE: We hypothesized that the anti-inflammatory properties of PAE would attenuate fatigue symptoms in a mouse model of restraint stress...
March 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29648617/society-of-behavioral-medicine-sbm-position-statement-enact-taxes-on-sugar-sweetened-beverages-to-prevent-chronic-disease
#14
Daniel R Taber, Akilah Dulin-Keita, Megan Fallon, Frank J Chaloupka, Tatiana Andreyeva, Marlene B Schwartz, Jennifer L Harris
The Society of Behavioral Medicine (SBM) encourages stakeholders to implement a sugar sweetened beverage excise tax. Sugar sweetened beverages are the largest source of added sugars in the USA and have detrimental effects on population health by increasing risks for chronic diseases. Based on existing research evidence, SBM supports an excise tax equivalent to at least 20% to meaningfully affect consumption patterns. As evidenced by research studies in Mexico and the USA, sugar sweetened beverage taxes can have positive impacts on population health and can raise significant tax revenue...
April 10, 2018: Translational Behavioral Medicine
https://www.readbyqxmd.com/read/29645365/pre-procedural-ultrasound-for-infant-lumbar-puncture-a-randomized-clinical-trial
#15
David Kessler, Vartan Pahalyants, Joshua Kriger, Gerald Behr, Peter Dayan
BACKGROUND: Our purpose was to determine the potential effect of pre-procedural ultrasound to increase lumbar puncture (LP) success compared with standard palpation method. Further, we assessed feasibility of and clinician satisfaction with a standardized ultrasound protocol. METHODS: This prospective, two-arm, parallel group randomized trial was conducted in a single-center pediatric emergency department. We compared pre-procedural ultrasound vs. palpation method on success with infant LPs...
April 12, 2018: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/29644557/colorectal-liver-metastases-does-the-future-of-precision-medicine-lie-in-genetic-testing
#16
Carlotta Barbon, Georgios Antonios Margonis, Nikolaos Andreatos, Neda Rezaee, Kazunari Sasaki, Stefan Buettner, Christos Damaskos, Timothy M Pawlik, Jin He, Christopher L Wolfgang, Matthew J Weiss
Colorectal liver metastases (CRLM) present an important clinical challenge in both surgical and medical oncology. Despite improvements in management, survival among patients undergoing resection of CRLM is still very variable and there is a paucity of clinical trial data and reliable biomarkers that could guide prognostic forecasts, treatment selection, and follow-up. Fortunately, recent advances in molecular biology and tumor sequencing have identified a number of critical genetic loci and proliferation markers that may hold the key to understanding the biologic behavior of CRLM; specifically, mutations of KRAS, BRAF, TP53, PIK3CA, APC, expression of Ki-67, and the presence of microsatellite instability appear to have a decisive impact on prognosis and response to treatment in patients with CRLM...
April 11, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29642950/melliferous-insects-and-the-uses-assigned-to-their-products-in-the-northern-yungas-of-salta-argentina
#17
Fabio Fernando Flores, Norma Inés Hilgert, Liliana Concepción Lupo
BACKGROUND: The order Hymenoptera comprises melliferous insects (bees, wasps and bumblebees); among them, stingless bees comprise a diverse group of eusocial insects present in tropical and subtropical areas. Of a total of approximately 500 species, 400 are found in the Neotropics. On the continent of America, before the introduction of Apis mellifera, these insects represented the main source of honey and wax. In Argentina, ethnobiological investigations had been carried out on this group of insects, principally in the Atlantic Forest and Chaco regions...
April 11, 2018: Journal of Ethnobiology and Ethnomedicine
https://www.readbyqxmd.com/read/29642573/3d-printing-of-thermo-responsive-methylcellulose-hydrogels-for-cell-sheet-engineering
#18
Andrea Cochis, Lorenzo Bonetti, Rita Sorrentino, Nicola Contessi Negrini, Federico Grassi, Massimiliano Leigheb, Lia Rimondini, Silvia Farè
A possible strategy in regenerative medicine is cell-sheet engineering (CSE), i.e., developing smart cell culture surfaces from which to obtain intact cell sheets (CS). The main goal of this study was to develop 3D printing via extrusion-based bioprinting of methylcellulose (MC)-based hydrogels. Hydrogels were prepared by mixing MC powder in saline solutions (Na₂SO₄ and PBS). MC-based hydrogels were analyzed to investigate the rheological behavior and thus optimize the printing process parameters. Cells were tested in vitro on ring-shaped printed hydrogels; bulk MC hydrogels were used for comparison...
April 10, 2018: Materials
https://www.readbyqxmd.com/read/29642394/neuroprotective-effects-of-platonin-a-therapeutic-immunomodulating-medicine-on-traumatic-brain-injury-in-mice-after-controlled-cortical-impact
#19
Ting-Lin Yen, Chao-Chien Chang, Chi-Li Chung, Wen-Chin Ko, Chih-Hao Yang, Cheng-Ying Hsieh
Traumatic brain injury (TBI) is one of the leading causes of mortality worldwide and leads to persistent cognitive, sensory, motor dysfunction, and emotional disorders. TBI-caused primary injury results in structural damage to brain tissues. Following the primary injury, secondary injuries which are accompanied by neuroinflammation, microglial activation, and additional cell death subsequently occur. Platonin, a cyanine photosensitizing dye, has been used to treat trauma, ulcers, and some types of acute inflammation...
April 6, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29629053/effective-factors-on-menstrual-health-among-female-students-in-bam-city-a-qualitative-study
#20
Mohammad Ali Morowatisharifabad, Aliakbar Vaezi, Neda Mohammadinia
Background: Menarche is an independent puberty event in a girl's life, and is associated with physical growth, ability in marriage and fertility. Therefore, poor menstrual health can be a major determinant of morbidity, as well as physical, mental and social problems in this age group. Objective: The aim of this study was to explore the effective factors on menstrual health among female students in Bam city. Methods: The qualitative study was conducted using content analysis approach in 2017...
February 2018: Electronic Physician
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