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https://www.readbyqxmd.com/read/29049120/a-contemporary-medicolegal-analysis-of-outpatient-medication-management-in-chronic-pain
#1
Christopher R Abrecht, Ethan Y Brovman, Penny Greenberg, Ellen Song, James P Rathmell, Richard D Urman
BACKGROUND: Opioids are frequently used in chronic pain management but are associated with significant morbidity and mortality in some patient populations. An important avenue for identifying complications-including serious or rare complications-is the study of closed malpractice claims. The present study is intended to complement the existing closed claims literature by drawing on claims from a more recent timeframe through a partnership with a large malpractice carrier, the Controlled Risk Insurance Company (CRICO)...
November 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29048981/women-and-the-decision-to-leave-linger-or-lean-in-predictors-of-intent-to-leave-and-aspirations-to-leadership-and-advancement-in-academic-medicine
#2
Elizabeth H Ellinas, Nadya Fouad, Angela Byars-Winston
BACKGROUND: The Association of American Medical Colleges reports continued low rates of female faculty as professors and in leadership positions. While attrition and discrimination have both been proposed as explanations, recent literature has suggested that women's professional motivations, ingrained behavior, and perceptions of organizational support may also play a role. METHODS: The authors employed a series of scales informed by the turnover theory (which predicts intent to leave an organization), previously validated and used in business and engineering studies, but rarely used in academic medicine...
October 19, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/29048849/-preparation-and-evaluation-of-hydrophilic-interaction-reversed-phase-mixed-mode-chromatographic-packing-based-on-polylsilsesquioxane-microspheres
#3
Qiannan Lü
Hydrophilic interaction (HILIC)/reversed-phase (RPLC) mixed-mode chromatography is widely used in separating both hydrophobic and hydrophilic compounds, but its pH range is limited which is harmful to the separation of alkaline drugs. Monodispersed and porous cysteine-modified vinyl functionalized polymethylsilsesquioxane (C-V-PMSQ) microspheres were prepared by thiol-ene click chemistry. Elemental analysis revealed that cysteine was successfully bonded to the surface of microspheres. C-V-PMSQ microspheres had excellent monodispersity, favorable chemical stability and simple preparation process...
September 8, 2017: Se Pu, Chinese Journal of Chromatography
https://www.readbyqxmd.com/read/29048455/improving-knowledge-and-behaviors-on-diet-and-physical-activity-in-children-results-of-a-pilot-randomized-field-trial
#4
G La Torre, A Mannocci, R Saulle, A Sinopoli, V D'Egidio, C Sestili, R Manfuso, D Masala
BACKGROUND: The aim of this study was to increase the knowledge of healthy eating, to encourage change in nutritional behavior in accordance with the Mediterranean diet and to promote physical activity in children aged 7 to 9 years and their parents in a school setting through the use of cards and board games of the project Giochiamo (Let us play). METHODS: This experimental randomized field trial enrolled children in a school setting. The trial consisted of two phases...
November 2017: Annali di Igiene: Medicina Preventiva e di Comunità
https://www.readbyqxmd.com/read/29048378/analysis-of-non-volatile-chemical-constituents-of-menthae-haplocalycis-herba-by-ultra-high-performance-liquid-chromatography-high-resolution-mass-spectrometry
#5
Lu-Lu Xu, Jing-Jing Xu, Kun-Rui Zhong, Zhan-Peng Shang, Fei Wang, Ru-Feng Wang, Le Zhang, Jia-Yu Zhang, Bin Liu
Menthae Haplocalycis herba, one kind of Chinese edible herbs, has been widely utilized for the clinical use in China for thousands of years. Over the last decades, studies on chemical constituents of Menthae Haplocalycis herba have been widely performed. However, less attention has been paid to non-volatile components which are also responsible for its medical efficacy than the volatile constituents. Therefore, a rapid and sensitive method was developed for the comprehensive identification of the non-volatile constituents in Menthae Haplocalycis herba using ultra-high performance liquid chromatography coupled with linear ion trap-Orbitrap mass spectrometry (UHPLC-LTQ-Orbitrap)...
October 19, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29048168/comment-on-the-ecstasy-and-agony-of-assay-interference-compounds
#6
Peter W Kenny
.A recent editorial (Aldrich et al, The Ecstasy and Agony of Assay Interference Compounds, J. Chem. Inf. MODEL: , 2017, 57, 387-390) is examined critically. When assessing assay hits from screening, it is important to draw a distinction between false positives, that have no effect on target function, and compounds that affect target function through an undesirable mechanism of action. Observation of frequent-hitter behavior for a compound should be regarded as circumstantial evidence, rather than definitive proof, that the compound has interfered with assay readouts or acted through an undesirable mechanism of action...
October 19, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/29046810/competency-in-supportive-supervision-a-study-of-public-sector-medicines-management-supervisors-in-uganda
#7
Rachael Henry, Lynda Nantongo, Anita Katharina Wagner, Martha Embrey, Birna Trap
BACKGROUND: Supportive supervision has been found to be more effective than corrective fault-oriented inspections. Uganda's Ministry of Health in 2012 implemented a comprehensive strategy (SPARS) to build medicines management capacity in public sector health facilities. The approach includes supportive supervision. This structured observational study assesses supportive supervision competency among medicines management supervisors (MMS). METHOD: The study used structured observations of two groups of five purposely selected MMS-one group supervising facilities with greater medicines management improvement during one year of SPARS and one group with less improvement, based on quantitative metrics...
2017: Journal of Pharmaceutical Policy and Practice
https://www.readbyqxmd.com/read/29043285/the-relationship-between-health-locus-of-control-and-health-behaviors-in-emergency-medicine-personnel
#8
Mansour Pourhoseinzadeh, Mahin Gheibizadeh, Mehrnaz Moradikalboland
BACKGROUND: Health locus of control defined as individual beliefs based on past experiences in health issues and having external or internal control over them, could affect health. Health locus of control plays a role in health behaviors. We aimed to investigate the relationship between health locus of control and health behavior in emergency medical personnel in Ahvaz during 2016. METHODS: This is a cross-sectional descriptive study, which began in August 2016 for a period of six months on 215 emergency medical personnel in Ahvaz who were selected randomly...
October 2017: International Journal of Community Based Nursing and Midwifery
https://www.readbyqxmd.com/read/29040066/evaluation-of-oral-multi-herbal-preparation-of-dashmoolarishta-on-mice-model-of-osteoarthritis
#9
Yashashri C Shetty, Santosh Godbharle, Smita Brahma, Sweta Salgaonkar, Nirmala N Rege
BACKGROUND: Osteoarthritis (OA) is a chronic progressive disease commonly affecting the hip and knee joints. Although synthetic drugs are available and afford symptomatic relief, their side effects pose limitations to their continuous use. So, this research was focused on extracting drugs from indigenous medicinal plants that could have a beneficial effect on osteoarthritis. Dashmoolarishta is one such preparation whose effects have never been studied in comparison with recent drugs like hyaluronic acid (HA), hence this particular study was undertaken...
October 17, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/29039514/5-6-7-3-4-5-hexamethoxyflavone-inhibits-growth-of-triple-negative-breast-cancer-cells-via-suppression-of-mapk-and-akt-signaling-pathways-and-arresting-cell-cycle
#10
Natasha Borah, Shimara Gunawardana, Haydee Torres, Susan McDonnell, Severine Van Slambrouck
Natural components continue to be an important source for the discovery and development of novel anticancer agents. Polymethoxyflavones are a class of flavonoids found in citrus fruits and medicinal plants used in traditional medicine. In the present study, the anticancer activity of the well-known nobiletin (5,6,7,8,3',4'-hexamethoxyflavone) was compared against its less studied structural isomer 5,6,7,3',4',5'-hexamethoxyflavone. These compounds were evaluated on the Hs578T triple-negative breast cancer cell line and its more migratory subclone Hs578Ts(i)8...
October 13, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29038950/firing-a-loaded-gun-during-sleep-in-an-elderly-man-with-a-perfect-storm-of-risk-factors-including-severe-obstructive-sleep-apnea
#11
Francesca Ingravallo, Carlos H Schenck, Ernesto D'Aloja, Monica Puligheddu
PURPOSE: We report a case of firing a loaded gun during sleep in a geriatric patient with undiagnosed major sleep disorders and multiple risk factors for sleep violence. Polysomnographic findings, diagnostic challenges, and forensic implications in this unprecedented geriatric case are discussed. METHODS: A 75-year-old employed man, married for 32 years, presented to a sleep center reporting to having fired a shot in his bedroom during sleep while his wife was away, without memory of hearing the gunshot...
October 16, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29037915/linalool-rich-essential-oils-from-the-amazon-display-antidepressant-type-effect-in-rodents
#12
Éverton Renan Q Dos Santos, Cristiane Socorro F Maia, Enéas A Fontes Junior, Ademar S Melo, Bruno G Pinheiro, José Guilherme S Maia
ETHNOPHARMACOLOGICAL RELEVANCE: The essential oils of the leaves of Aniba rosaeodora (pau-rosa), Aniba parviflora (macacaporanga) and Aeollanthus suaveolens (catinga-de-mulata), rich in linalool, are used in the traditional medicine of the Brazilian Amazon for its effects on the central nervous system, such as sedative, anticonvulsant and antidepressant, among other therapeutic properties. AIM OF THE STUDY: To analyze the chemical composition of these oils and to evaluate their neurobehavioral effects in rodents, based on different and established behavioral tests...
October 13, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29032167/evaluation-of-embryotoxic-and-teratogenic-effects-of-the-oil-extracted-from-caryocar-brasiliense-cambess-pulp-in-rats
#13
Giseli Karenina Traesel, Fernando Freitas de Lima, Ariany Carvalho Dos Santos, Roosevelt Isaias Carvalho Souza, Daniela Torres Cantadori, Carlos Roberto Kretschmer, Vinicius João Navarini, Silvia Aparecida Oesterreich
The objective of this study was to evaluate the maternal, embryotoxic and teratogenic effects of Caryocar brasiliense pulp oil (OPCB), oil widely used in Brazilian cuisine and traditional medicine. Pregnant Wistar female rats were used in this study for three treatment groups (250, 500 and 1000 mg/kg/day) and a control group. The OPCB was administered orally throughout the period of organogenesis of females (6th until the 15th day of gestation). The pregnant females were gross necropsied on d20, followed by maternal and fetus examination, to evaluate the teratogenicity, reproductive and developmental performance of OPCB...
October 12, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29031538/everyday-stress-response-targets-in-the-science-of-behavior-change
#14
Joshua M Smyth, Martin J Sliwinski, Matthew J Zawadzki, Stacey B Scott, David E Conroy, Stephanie T Lanza, David Marcusson-Clavertz, Jinhyuk Kim, Robert S Stawski, Catherine M Stoney, Orfeu M Buxton, Christopher N Sciamanna, Paige M Green, David M Almeida
Stress is an established risk factor for negative health outcomes, and responses to everyday stress can interfere with health behaviors such as exercise and sleep. In accordance with the Science of Behavior Change (SOBC) program, we apply an experimental medicine approach to identifying stress response targets, developing stress response assays, intervening upon these targets, and testing intervention effectiveness. We evaluate an ecologically valid, within-person approach to measuring the deleterious effects of everyday stress on physical activity and sleep patterns, examining multiple stress response components (i...
September 28, 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/29030249/sex-as-a-biological-variable-drug-use-and-abuse
#15
Anthony L Riley, Briana J Hempel, Matthew M Clasen
The study of sex as a biological variable is a necessary emphasis across a wide array of endpoints, including basic neuroscience, medicine, mental health, physiology and behavior. The present review summarizes work from clinical and preclinical populations on sex differences in drug use and abuse, ranging from initiation to escalation/dysregulation and from drug cessation/abstinence to relapse. These differences are analyzed in the context of the addiction cycle conceptualization of Koob and his colleagues and address patterns of drug use (binge/intoxication), motivation underlying its use (withdrawal/negative affect) and likelihood and causes of craving and relapse of drug taking (anticipation/preoccupation)...
October 10, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/29029586/use-and-misuse-of-opioids-in-chronic-pain
#16
Nora Volkow, Helene Benveniste, A Thomas McLellan
The prescribing of opioid analgesics for pain management-particularly for management of chronic noncancer pain (CNCP)-has increased more than fourfold in the United States since the mid-1990s. Yet there is mounting evidence that opioids have only limited effectiveness in the management of CNCP, and the increased availability of prescribed opioids has contributed to upsurges in opioid-related addiction cases and overdose deaths. These concerns have led to critical revisiting and modification of prior pain management practices (e...
October 13, 2017: Annual Review of Medicine
https://www.readbyqxmd.com/read/29025298/twelve-tips-for-using-applied-improvisation-in-medical-education
#17
Krista Hoffmann-Longtin, Jonathan P Rossing, Elizabeth Weinstein
Future physicians will practice medicine in a more complex environment than ever, where skills of interpersonal communication, collaboration and adaptability to change are critical. Applied improvisation (or AI) is an instructional strategy which adapts the concepts of improvisational theater to teach these types of complex skills in other contexts. Unique to AI is its very active teaching approach, adapting theater games to help learners meet curricular objectives. In medical education, AI is particularly helpful when attempting to build students' comfort with and skills in complex, interpersonal behaviors such as effective listening, person-centeredness, teamwork and communication...
October 12, 2017: Medical Teacher
https://www.readbyqxmd.com/read/29025113/innovative-technology-using-virtual-reality-in-the-treatment-of-pain-does-it-reduce-pain-via-distraction-or-is-there-more-to-it
#18
Anita Gupta, Kevin Scott, Matthew Dukewich
Objective: Virtual reality (VR) is an exciting new technology with almost endless possible uses in medicine. One area it has shown promise is pain management. This selective review focused on studies that gave evidence to the distraction or nondistraction mechanisms by which VR leads to the treatment of pain. Methods: The review looked at articles from 2000 to July 29, 2016, focusing on studies concerning mechanisms by which virtual reality can augment pain relief...
August 31, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29024545/role-of-substrate-biomechanics-in-controlling-stem-cell-fate-implications-in-regenerative-medicine
#19
REVIEW
Laura Macri-Pellizzeri, Elena M De-Juan-Pardo, Felipe Prosper, Beatriz Pelacho
Tissue-specific stem cells reside in a specialized environment known as the niche. The niche plays a central role in the regulation of cell behavior and, through the concerted action of soluble molecules, supportive somatic cells and extracellular matrix-components, directs stem cells to proliferate, differentiate or remain quiescent. Great efforts have been done to decompose and separately analyze the contribution of these cues in the in vivo environment. Specifically, the mechanical properties of the extracellular matrix influence many aspects of cell behavior, including self-renewal and differentiation...
October 11, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29024454/disclosure-of-personalized-rheumatoid-arthritis-risk-using-genetics-biomarkers-and-lifestyle-factors-to-motivate-health-behavior-improvements-a-randomized-controlled-trial
#20
Jeffrey A Sparks, Maura D Iversen, Zhi Yu, Nellie A Triedman, Maria G Prado, Rachel Miller Kroouze, Sarah S Kalia, Michael L Atkinson, Elinor A Mody, Simon M Helfgott, Derrick J Todd, Paul F Dellaripa, Bonnie L Bermas, Karen H Costenbader, Kevin D Deane, Bing Lu, Robert C Green, Elizabeth W Karlson
OBJECTIVE: To determine the effect of disclosure of rheumatoid arthritis (RA) risk personalized with genetics, biomarkers, and lifestyle factors on health behavior intentions. METHODS: We performed a randomized controlled trial among first-degree relatives without RA. Subjects assigned to the Personalized Risk Estimator for RA (PRE-RA) group received the web-based PRE-RA tool for RA risk factor education and disclosure of personalized RA risk estimates including genotype/autoantibody results and behaviors (n=158)...
October 12, 2017: Arthritis Care & Research
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