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The results of investigation on impact of the foam form of sclerosant in experiment on 80 mongrel white rats, were presented. Sclerosing action of 0.5%, 2%, 3% solution of polydocanol in a microfoam form was studied after its infusion into lateral caudal vein of the rat. Quantity of preparation 0,5 cm3 was determined in accordance to the vein volume. Clinical and macroscopic estimation of the preparation action on internal organs and caudal rat's vein was conducted on the 10th min, every day during 1 week and on the 30th day...
August 2014: Klinichna Khirurhiia
V I Palamarchuk, Iu I Bondarenko, Iu P Titova, I V Irkin, V I Zarits'ka
The results of investigation on impact of the foam form of sclerosant in experiment on 80 mongrel white rats, were presented. Sclerosing action of 0.5%, 2%, 3% solution of polydocanol in a microfoam form was studied after its infusion into lateral caudal vein of the rat. Quantity of preparation 0,5 cm3 was determined in accordance to the vein volume. Clinical and macroscopic estimation of the preparation action on internal organs and caudal rat's vein was conducted on the 10th min, every day during 1 week and on the 30th day...
August 2014: Klinichna Khirurhiia
Darío Morais, Teresa Millás, Roberto Zarrabeitia, Luisa M Botella, Ana Almaraz
Hereditary Haemorrhagic Telangiectasia or Rendu-Osler-Weber syndrome is a rare autosomal dominant vascular disease characterized by mucocutaneous and gastrointestinal telangiectases and localized arteriovenous malformations in lung, brain and liver. Epistaxis, due to rupture of telangiectases of the nasal mucosa, is the most frequent clinical manifestation, leading in many cases to severe impairment of the quality of life in the patients. Though several treatments have been used to reduce epistaxis, none have been completely effective, with the exception of polydocanol (Aethoxysklerol®) in submucosal or subpericondrial injections, which was first presented in 2000 with very good results...
March 2012: Rhinology
Sasa Grgov, Perica Stamenković
INTRODUCTION: Endoscopic band ligation (EBL) is superior to endoscopic injection sclerotherapy (EIS) of oesophageal varices, however, EBL is associated with a higher rate of variceal recurrences. OBJECTIVE: To examine whether the reduction of recurrent varices can be achieved by additional sclerotherapy of remnant little varices after ligation. METHODS: Forty-eight patients with liver cirrhosis who had previously bled from oesophageal varices were examined...
May 2011: Srpski Arhiv za Celokupno Lekarstvo
Tomohiro Shimo, Kohji Hidaka, Shinpei Yanagawa, Waki Kadota, Shigehiko Kawakami, Hideaki Tsuchida
A 4-year-old boy, weighing 15.6 kg, experienced two episodes of cardiac arrest during the eight sessions of sclerotherapy under general anesthesia. Although cardiac arrest had been documented after accidental extubation during the seventh procedure, the specific cause had not been identified. For the eighth procedure, anesthesia was again induced and maintained with nitrous oxide and sevoflurane. A total of 10 ml of 3% polydocanol was injected. Approximately five minutes after the injection, his heart rate slowed and asystole developed...
January 2005: Masui. the Japanese Journal of Anesthesiology
Frank Hanisch, T Müller, M Krivokuca, M Winterholler
OBJECTIVE: Paradoxical embolism via a patent foramen ovale (PFO) has been identified as a potential risk factor for ischaemic stroke. Such occurrences are associated with risk factors for deep vein thrombosis (DVT), e. g. pregnancy, immobilisation, and surgery of the lower limbs. OBSERVATION: A 54-year-old otherwise healthy female presented with acute onset motoric aphasia and brachiofacial right hemiparesis. The cranial computed tomography showed a left striatal ischaemic infarction...
May 28, 2004: European Journal of Medical Research
Janusz Pluta, Bozena Karolewicz
The aim of the study was to prepare and evaluate excipients with bioadhesive, properties obtained by means of lipophilic adjuvants which may be used as the active substance carriers providing prolonged contact with the oral mucosa. Light liquid paraffin, polyethylene, polydocanol and polymers with mucoadhesive properties: methylcellulose, pectin and gelatin have all been used in the study. The addition of paraffin to the excipients has been found to prolong the time of their washing down in water and in artificial saliva as well as to affect the rheological properties of the obtained formulations in comparison to standard preparations obtained on the basis of hydrophilic and lipophilic excipients...
2003: Polimery W Medycynie
S Deepthi, A Johnson, V Pattabhi
Polydocanol has a wide range of medical applications, especially in sclerotherapy of many diseases such as gastrointestinal antiplastia, oesophageal haemangioma etc. It is of interest to study the mode of binding of this medically important detergent and its subsequent action on proteins. Here, three crystal structures of serine protease trypsin are reported in the presence of varying concentrations of polydocanol in order to elucidate its mode of binding and interactions with proteins. Polydocanol binds to the protein with its hydrophilic head rather than the hydrophobic tail as is the case with other detergents such as SDS and MEGA-8...
November 2001: Acta Crystallographica. Section D, Biological Crystallography
L Lopez, R B Dilley, J A Henriquez
BACKGROUND: Cutaneous hyperpigmentation after venous sclerotherapy is an adverse sequelae of difficult management. OBJECTIVE: To evaluate the degree of depigmentation with the use of deferoxamine mesylate (DM) in patients with postsclerotherapy hyperpigmentation treated with polydocanol (POL) for telangiectasias and reticular veins (0.2-5 mm diameter) and varicose veins (5-8 mm diameter). METHODS: The experimental group of 36 female patients (mean age 37 years) was divided in two groups...
September 2001: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
L Di Liberato, V Sirolli, R Lattanzio, L Amoroso, G Del Rosso, P Cappelli, M Bonomini
Gastroenteric angiodysplasia is an important cause of haemorrhage in chronic renal failure patients. This paper reports on 2 patients on maintenance haemodialysis with upper gastrointestinal bleeding due to different manifestations of angiodysplasic lesions (sudden appearance of haematemesis and melaena in one case, progressive anaemia with apparent resistance to erythropoietin in the other case). Exploratory endoscope examination of the first digestive tract showed in both cases the presence of bleeding angiodysplasic lesions...
July 1999: International Journal of Artificial Organs
J L Cisneros, R Del Rio, J Palou
BACKGROUND: The combination of low concentrations of sclerosing solution and the Nd:YAG, Q-switched laser with multiple (quadruple) frequency provides good results in the treatment of telangiectases and reticular varicose veins of the lower extremities, as well as pigmentation that may appear during sclerotherapy. OBJECTIVE: This paper is based on a series of patients with telangiectases and reticular veins who were treated with sclerotherapy and the Nd:YAG, Q-switched laser with quadruple frequency...
October 1998: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
Y T Hsu, R J Youle
Bcl-2, Bcl-XL, and Bax are members of the Bcl-2 family that play important roles in apoptosis regulation. These proteins are believed to be membrane-bound and to regulate apoptosis through formation of homo- and heterodimers. However, we recently found by subcellular fractionation that whereas Bcl-2 is predominantly a membrane protein as previously reported, Bax and a significant fraction of Bcl-XL are soluble in thymocyte and splenocyte extracts. In addition, we have demonstrated that the ability of Bax to form dimers appears to be a detergent-induced phenomenon that coincides with a detergent-induced conformational change...
April 24, 1998: Journal of Biological Chemistry
T Aoki, K Okagawa, Y Uemura, K Nishioka, H Miyata, T Ukei, K Miyauchi, T Terashima, T Kaneko, S Mizunoya
We report herein the case of a 46-year-old man in whom an esophageal hemangioma was successfully treated by endoscopic injection sclerotherapy (EIS). The patient was admitted to hospital after a routine upper gastrointestinal series demonstrated a filling defect in the esophagus. Endoscopy, computed tomography (CT) images, and magnetic resonance imaging (MRI) subsequently revealed a hemangioma in the middle esophagus. EIS was performed using 99% ethanol and 1% polydocanol, and 4 weeks later, the tumor had almost disappeared...
1997: Surgery Today
L A Fariña, H Villavicencio
Twenty male patients aged 26-79 years old, with symptomatic unilateral hydrocele, were treated by evacuation puncture and intracavitary instillation of 2 ml of a 3% polydocanol solution. In 13 cases, treatment was done ambulatory and only in the first few cases sperm cord anaesthetics was used. Regular follow-up of at least 6 months was made. No complications were encountered and only one third of patients complained of mild pain. In 12 cases (60%) hydrocele cure was achieved and 6 relapsed (another 2 were lost to follow-up)...
June 1994: Actas Urologicas Españolas
D Jaspersen, H Schwacha, B Sauer, J Wzatek, W Schorr, P Graf zu Dohna, C H Hammar
Within the framework of a retrospective study complications of endoscopic variceal sclerotherapy were analyzed. From April, 1, 1988 till August, 31, 1994 267 consecutive patients (158 male, 109 female, mean age 43 [27-78] years) with esophageal variceal hemorrhage due to liver cirrhosis and portal hypertension underwent endoscopic variceal injection treatment. Sclerotherapy was performed with 24.5 ml (12-34 ml) 1% of polydocanole on average per treatment. Each patient had 4.5 (2-7) therapy sessions on average...
July 1995: Leber, Magen, Darm
Y Kumagai, H Makuuchi, E Yamazaki
In 1978, the first Japanese report of sclerotherapy with the flexible esophagoscope was published. At the Second Meeting of the Japanese Society of Sclerotherapy for Esophageal Varices (August 1986), reports were given on over 4000 cases treated by over 70 groups of endoscopists using various methods and sclerosants. These cases included 15 (about 0.4%) in which esophageal perforation occurred, and other complications, some fatal, were also reported. The main problem is to reduce the frequency of these serious complications...
1987: Surgical Endoscopy
J Boix, R Planas, C Llorente, A Casals, J Romeu, R de León, P Humbert
We have reviewed our experience in urgent endoscopic sclerosis of bleeding esophageal veins in most patients (67.7%) secondary to alcoholic liver cirrhosis. Through the flexible gastroscope, 1% of polydocanol was injected intra and periveinaly for sclerosis. Initial and primary hemostasis was achieved in 90.3% and 87% of the cases respectively. Hemorrhage recurred in 14.2% of the patients. Hospital mortality was 38.7% (11 patients classified in Childs group C and 1 patient in group B), although only 19.3% of the patients died because of esophageal vein bleeding...
April 1989: Revista Clínica Española
A Lanas, J L Alonso, I Alberdi, A Cornago, R Trujillo, M Lachen
An investigation was made of the effect of emergency endoscopic sclerotherapy on the evaluation of digestive hemorrhage (HDA) secondary to gastroduodenal ulcer disease in two consecutive groups of patients. The control group included 92 patients and the sclerotherapy group contained 63. Both groups had the same management and basic treatment of hemodynamic stabilization, anti-H2 agents and alkaline . The sclerotherapy group also received a local injection of 1/10,000 (5-12 ml) adrenaline and 1% polydocanol (5-12 ml) if direct signs of hemorrhage (active bleeding, red clot, visible vessel) were seen at the time of early endoscopy...
November 1989: Revista Española de las Enfermedades del Aparato Digestivo
H Makuuchi, T Machimura, T Sugihara, T Mitomi, Y Kumagai, Y Shiina, T Miwa, E Yamazaki, H Shigeta
No abstract text is available yet for this article.
April 1990: Nihon Rinsho. Japanese Journal of Clinical Medicine
S Tamura, H Shiozaki, K Kobayashi, H Yano, H Tahara, M Miyata, T Mori
Thirty-five consecutive patients undergoing endoscopic injection sclerotherapy for esophageal varices were randomly allocated to either ranitidine-administered group (18 patients) or ranitidine-nonadministered group (17 patients), in an attempt to evaluate the efficacy of ranitidine for prevention and healing of postinjection ulcer with a prospective randomized trial. Two of seventeen patients in the nonadministered group dropped out of this trial because of development of gastric ulcer, so 18 patients in the first group were evaluated and compared with the 15 remaining patients in the second group...
April 1991: American Journal of Gastroenterology
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