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https://www.readbyqxmd.com/read/28443107/virus-based-microrna-silencing-and-overexpressing-in-common-wheat-triticum-aestivum-l
#1
Chao Jian, Ran Han, Qing Chi, Shijuan Wang, Meng Ma, Xiangli Liu, Huixian Zhao
MicroRNAs (miRNAs) are a class of endogenous small non-coding RNAs that arise from large RNA precursors with a stem-loop structure and play important roles in plant development and responses to environmental stress. Although a hundred and nineteen wheat miRNAs have been identified and registered in the miRBase (Release 21.0, June, 2014; http://www.mirbase.org), the functional characterization of these miRNAs in wheat growth and development is lagging due to lack of effective techniques to investigate endogenous miRNA functions in wheat...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28439350/transgender-related-education-in-plastic-surgery-and-urology-residency-programs
#2
Shane D Morrison, Geolani W Dy, H Jonathan Chong, Sarah K Holt, Nicholas B Vedder, Mathew D Sorensen, Byron D Joyner, Jeffrey B Friedrich
BACKGROUND: With increasing public awareness of and greater coverage for gender-confirming surgery by insurers, more transgender patients are likely to seek surgical transition. The degree to which plastic surgery and urology trainees are prepared to treat transgender patients is unknown. OBJECTIVE: We assessed the number of hours dedicated to transgender-oriented education in plastic surgery and urology residencies, and the impact of program director (PD) attitudes on provision of such training...
April 2017: Journal of Graduate Medical Education
https://www.readbyqxmd.com/read/28434236/incremental-validity-of-self-and-informant-report-of-personality-disorders-in-later-life
#3
Patrick J Cruitt, Thomas F Oltmanns
Research shows moderate agreement between different sources of information when assessing personality disorders (PDs) in older adults. The differences between measurement methods appear to be not only the result of measurement error, but also an indication that each source holds nonredundant information relevant to PD diagnosis. The current article examines three sources of diagnostic information (self-report, informant report, and clinical interview) and the utility of these instruments in predicting important outcomes in older adulthood...
April 1, 2017: Assessment
https://www.readbyqxmd.com/read/28432529/ginseng-derived-panaxadiol-saponins-promote-hematopoiesis-recovery-in-cyclophosphamide-induced-myelosuppressive-mice-potential-novel-treatment-of-chemotherapy-induced-cytopenias
#4
Xin Sun, Yan-Na Zhao, Song Qian, Rui-Lan Gao, Li-Ming Yin, Li-Pei Wang, Beng-Hock Chong, Su-Zhan Zhang
OBJECTIVE: To investigate the potential efficacy of panaxadiol saponins component (PDS-C), a biologically active fraction isolated from total ginsenosides, to reverse chemotherapy-induced myelosuppression and pancytopenia caused by cyclophamide (CTX). METHODS: Mice with myelosuppression induced by CTX were treated with PDS-C at a low- (20 mg/kg), moderate- (40 mg/kg), or high-dose (80 mg/kg) for 7 consecutive days. The level of peripheral white blood cell (WBC), neutrophil (NEU) and platelet (PLT) were measured, the histopathology and colony formation were observed, the protein kinase and transcription factors in hematopoietic cells were determined by immunohistochemical staining and Western blot...
April 22, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28431352/degradation-of-sulfamethoxazole-by-uv-uv-h2o2-and-uv-persulfate-pds-formation-of-oxidation-products-and-effect-of-bicarbonate
#5
Yi Yang, Xinglin Lu, Jin Jiang, Jun Ma, Guanqi Liu, Ying Cao, Weili Liu, Juan Li, Suyan Pang, Xiujuan Kong, Congwei Luo
The frequent detection of sulfamethoxazole (SMX) in wastewater and surface waters gives rise of concerns about their ecotoxicological effects and potential risks to induce antibacterial resistant genes. UV/hydrogen peroxide (UV/H2O2) and UV/persulfate (UV/PDS) advanced oxidation processes have been demonstrated to be effective for the elimination of SMX, but there is still a need for a deeper understanding of product formations. In this study, we identified and compared the transformation products of SMX in UV, UV/H2O2 and UV/PDS processes...
March 28, 2017: Water Research
https://www.readbyqxmd.com/read/28429364/application-of-gene-detection-technique-in-the-antenatal-diagnosis-of-hereditary-hearing-loss
#6
Y Fang, M-S Gu, F Suo, C-X Wang, X-H Liu, F-M Liu
OBJECTIVE: Gene chip and gene sequencing techniques were used to detect the main pathogenic genes in pregnant women with hereditary hearing loss. PATIENTS AND METHODS: From May 2015 to May 2016, 1080 pregnant in Xuzhou Maternal and Child Health Hospital were enrolled in this study. Women age range was 18 to 40 years. 4 genes and 9 mutation sites, including 4 sites (35delG, 176, 235delC and 299) in GJB2 gene, 2 sites (2168A>G and IVS-7-2A>G) in SLC26A4 (PDS) gene, 2 sites (1494C>T and 1555A>G) in 12s rRNA gene and 1 site (538C>T) in GJB3 gene, were detected using the GeeDom® 9-item hereditary hearing loss gene detection kit...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28424888/posttraumatic-growth-and-well-being-among-adolescents-and-young-adults-ayas-with-cancer-a-longitudinal-study
#7
O Husson, B Zebrack, R Block, L Embry, C Aguilar, B Hayes-Lattin, S Cole
PURPOSE: This study examines posttraumatic growth (PTG) among adolescents and young adults (AYAs) with cancer, as well as its correlates and trajectories over time. The study also explores the buffering role of PTG on the associations between posttraumatic stress (PTS), health-related quality of life (HRQoL), and psychological distress. METHODS: A multicenter, longitudinal, prospective study was conducted among AYA cancer patients aged 14-39 years. One hundred sixty-nine patients completed a self-report measure of PTG (PTGI) and PTS (PDS) 6, 12, and 24 months after baseline (within the first 4 months of diagnosis)...
April 19, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28423481/prevalence-of-gastric-motility-disorders-in-patients-with-functional-dyspepsia
#8
Haruki Asano, Toshihiko Tomita, Kumiko Nakamura, Takahisa Yamasaki, Takuya Okugawa, Takashi Kondo, Tomoaki Kono, Katsuyuki Tozawa, Yoshio Ohda, Tadayuki Oshima, Hirokazu Fukui, Kazuhito Fukushima, Shozo Hirota, Jiro Watari, Hiroto Miwa
Background/Aims: Gastric motility abnormalities have been considered to be pathophysiological features of functional dyspepsia (FD) that are closely related to dyspepsia symptoms, especially postprandial distress syndrome (PDS). The aims of this study are to (1) investigate the prevalence of gastric motility disorders and (2) evaluate the association between gastric motility abnormalities and dyspeptic symptoms using gastric scintigraphy in the PDS type of FD. Methods: Forty healthy subjects and 94 PDS type FD patients were enrolled in the study...
April 19, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28419119/plasma-ghrelin-level-and-plasma-ghrelin-obestatin-ratio-are-related-to-intestinal-metaplasia-in-elderly-patients-with-functional-dyspepsia
#9
Su Hwan Kim, Ji Won Kim, Junsu Byun, Ji Bong Jeong, Byeong Gwan Kim, Kook Lae Lee
BACKGROUND: Whether plasma ghrelin/obestatin levels are associated with Helicobacter pylori (H. pylori) infection, subtypes of functional dyspepsia (FD), and gastric mucosal histology has not yet been established in elderly patients. OBJECTIVE: The aim of this study was to determine whether plasma ghrelin and obestatin levels are related to gastric mucosal histology, H. pylori infection, and FD subtypes in elderly patients with FD. METHODS: Ninety-two patients diagnosed with FD and older than 60 years (median age 69...
2017: PloS One
https://www.readbyqxmd.com/read/28417546/novel-structure-for-high-performance-uv-photodetector-based-on-biocl-zno-hybrid-film
#10
Feng Teng, Weixin Ouyang, Yanmei Li, Lingxia Zheng, Xiaosheng Fang
A novel type of high performance ultraviolet (UV) photodetector (PD) based on a ZnO film has been prepared by incorporating a BiOCl nanostructure into the film. The responsivity of the BiOCl/ZnO hybrid film PD in UV region can reach 182.87 mA W(-1) , which is about 2.72 and 6.87 times for that of TiO2 /ZnO hybrid film PD and pure ZnO film PD. The rise/decay time of BiOCl/ZnO hybrid film PD is 25.83/11.25 s, which is much shorter than that of TiO2 /ZnO hybrid film PD (51.94/26.05 s) and pure ZnO film PD (69...
April 18, 2017: Small
https://www.readbyqxmd.com/read/28416211/phenotypic-heterogeneity-of-human-retinal-pigment-epithelial-cells-in-passaged-cell-populations
#11
Rie Sonoi, Mee-Hae Kim, Kenta Yamada, Masahiro Kino-Oka
Human retinal pigment epithelial (RPE) cells at different population doublings (PDs) were cultured for 28 days to examine their phenotypic heterogeneity in a confluent state. In an early population (PD = 2.8), cells showed a cobblestone-like appearance (type I), which gradually became small and tight, and eventually exhibited dark pigmentation. Some cells showed a dome-like structure (type II), which detached from the culture surface during culture. With increasing PD, the cells showed active migration that caused a shift in phenotype from a single layer of large, flattened cells (type III) to a multiple cell layers (stratified) with flattened, irregularly shaped cells (type IV)...
April 14, 2017: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/28414014/do-dsm-5-section-ii-personality-disorders-and-section-iii-personality-trait-domains-reflect-the-same-genetic-and-environmental-risk-factors
#12
T Reichborn-Kjennerud, R F Krueger, E Ystrom, F A Torvik, T H Rosenström, S H Aggen, S C South, M C Neale, G P Knudsen, K S Kendler, N O Czajkowski
BACKGROUND: DSM-5 includes two conceptualizations of personality disorders (PDs). The classification in Section II is identical to the one found in DSM-IV, and includes 10 categorical PDs. The Alternative Model (Section III) includes criteria for dimensional measures of maladaptive personality traits organized into five domains. The degree to which the two conceptualizations reflect the same etiological factors is not known. METHODS: We use data from a large population-based sample of adult twins from the Norwegian Institute of Public Health Twin Panel on interview-based DSM-IV PDs and a short self-report inventory that indexes the five domains of the DSM-5 Alternative Model plus a domain explicitly targeting compulsivity...
April 17, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28411948/reporting-denominator-data-is-essential-for-benchmarking-and-quality-standards-in-ovarian-cancer
#13
Andrew Phillips, Janos Balega, James Nevin, Kavita Singh, Ahmed Elattar, Sean Kehoe, Sudha Sundar
OBJECTIVE: Combined surgery and platinum-based chemotherapy is the internationally agreed standard therapy for advanced ovarian cancer (AOC). However international cancer registry datasets demonstrate a significant proportion of patients do not receive both or either therapies. Our objective was to evaluate the effect of total patient cohort data ('Denominator') on median overall survival (OS) and determine how frequently this was reported in literature. METHODS: We retrospectively reviewed OS outcomes for 593 patients diagnosed with AOC for 77 months at a regional cancer centre...
April 12, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28410728/corneal-collagen-crosslinking-and-pigment-dispersion-syndrome
#14
Benjamin R LaHood, Sacha Moore
We describe the case of a keratoconus patient with pigment dispersion syndrome (PDS) who was treated for progressive corneal ectasia with corneal collagen crosslinking (CXL). Pigment dispersion syndrome has been shown to have associated morphologic changes of the corneal endothelium. Corneal CXL has the potential to cause toxicity to the corneal endothelium, and adjacent pigment might increase the likelihood of damage. In this case, the presence of PDS had no detrimental effect on the outcome of treatment, and no complications were observed at 12 months follow-up, indicating that it may be safe to perform corneal CXL in the setting of PDS...
March 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28409537/impact-of-pneumococcal-conjugate-vaccines-for-children-in-high-and-non-high-income-countries
#15
Robert Cohen, Jérémie François Cohen, Martin Chalumeau, Corinne Levy
The high level of effectiveness of pneumococcal conjugate vaccines (PCVs) was demonstrated initially in high-income countries (HICs). However, because the burden of pneumococcal diseases (PDs) is greater in non-high-income countries (NHICs) than HICs, the assessment of these vaccines in this latter setting is crucial. Areas Covered: PubMed was used to search for literature related to the effectiveness of PCVs. Several studies described the effectiveness of PCVs in NHICs, and we compare the impact of PCVs on the incidence of invasive pneumococcal disease (IPD) and pneumonia in HICs and NHICs...
April 14, 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/28409475/clinical-and-laboratory-diagnosis-of-peroxisomal-disorders
#16
Ronald J A Wanders, Femke C C Klouwer, Sacha Ferdinandusse, Hans R Waterham, Bwee Tien Poll-Thé
The peroxisomal disorders (PDs) are a heterogeneous group of genetic diseases in man caused by an impairment in peroxisome biogenesis or one of the metabolic functions of peroxisomes. Thanks to the revolutionary technical developments in gene sequencing methods and their increased use in patient diagnosis, the field of genetic diseases in general and peroxisomal disorders in particular has dramatically changed in the last few years. Indeed, several novel peroxisomal disorders have been identified recently and in addition it has been realized that the phenotypic spectrum of patients affected by a PD keeps widening, which makes clinical recognition of peroxisomal patients increasingly difficult...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28407517/social-status-strategy-in-early-adolescent-girls-testosterone-and-value-based-decision-making
#17
Stephanie L Cardoos, Ahna Ballonoff Suleiman, Megan Johnson, Wouter van den Bos, Stephen P Hinshaw, Ronald E Dahl
There has been strong interest, spanning several disciplines, in understanding adolescence as a developmental period of increased risk-taking behavior. Our goals focus on one line of investigation within this larger developmental risk framework. Specifically, we examined levels of pubertal hormones in girls in relation to their willingness to take greater financial risks to gain social status. To this end, we tested the hypothesis that higher levels of testosterone during the ages of pubertal maturation are associated with a greater willingness to sacrifice money for social admiration...
March 31, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28403655/prevalence-mortality-and-health-care-use-among-patients-with-cluster-b-personality-disorders-clinically-diagnosed-in-quebec
#18
Lionel Cailhol, Éric Pelletier, Louis Rochette, Lise Laporte, Pierre David, Évens Villeneuve, Joel Paris, Alain Lesage
BACKGROUND: Cluster B personality disorders (PDs) are prevalent mental health conditions in the general population (1%-6% depending on the subtype and study). Affected patients are known to be heavier users of both mental and medical health care systems than patients with other clinical conditions such as depression. METHODS: Several rates were estimated using data from the integrated monitoring system for chronic diseases in the province of Quebec, Canada. It provides a profile of annual and period prevalence rates, mortality rates, and years of lost life as well as health care utilisation rates for Quebec residents...
January 1, 2017: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
https://www.readbyqxmd.com/read/28400464/utilisation-of-radiology-rotations-in-acgme-accredited-general-surgery-programmes
#19
Joseph J Eid, Francisco Igor Macedo, Vijay K Mittal
BACKGROUND: General surgery (GS) residents are often required to provide immediate preliminary interpretations of radiological images, especially in critical situations. It is unclear whether residents in Accreditation Council for Graduate Medical Education-accredited GS programmes receive sufficient radiological training to deliver adequate patient care. OBJECTIVES: Determine the utilisation of radiology rotations (RR) during GS residency. METHODS: Between February and March 2015, a pilot voluntary 19-item survey was electronically distributed to GS programme directors (PDs) regarding the availability and value of a RR during GS training...
April 11, 2017: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/28397451/the-stress-relaxation-process-in-sutures-tied-with-a-surgeon-s-knot-in-a-simulated-biological-environment
#20
Aneta Liber-Kneć, Sylwia Łagan
BACKGROUND: The exact characteristics of sutures are not only the basis for selecting from among different types of suture, but also provide the necessary information for the design of new surgical sutures. Apart from information relating to the breaking load of a suture reported in pharmacopoeias, the viscoelastic properties of sutures can be an additional selection criterium - one that influences stitching quality, especially when there is a risk of wound dehiscence. OBJECTIVES: The aim of the study was to assess the stress relaxation process for 3 polymeric sutures in an environment simulating the conditions in a living organism and (for comparison) in room conditions...
July 2016: Polimery W Medycynie
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