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https://www.readbyqxmd.com/read/28812160/robotic-versus-open-pancreatoduodenectomy-a-propensity-score-matched-analysis-based-on-factors-predictive-of-postoperative-pancreatic-fistula
#1
Niccolò Napoli, Emanuele F Kauffmann, Francesca Menonna, Francesca Costa, Sara Iacopi, Gabriella Amorese, Serena Giorgi, Angelo Baggiani, Ugo Boggi
BACKGROUND: Improvement in morbidity of pancreatoduodenectomy (PD) largely depends on the reduction in the incidence of clinically relevant (CR) postoperative pancreatic fistula (POPF). METHODS: After internal validation of the clinical risk score (CRS) of POPF, and identification of other predictive factors for POPF, robotic (RPD), and open (OPD) PDs were stratified into risk categories and matched by propensity scores. The primary endpoint of this study was incidence of CR-POPF...
August 15, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28809820/certain-dietary-habits-contribute-to-the-functional-dyspepsia-in-south-china-rural-area
#2
Ji-Hao Xu, Yu Lai, Li-Ping Zhuang, Can-Ze Huang, Chu-Qiang Li, Qi-Kui Chen, Tao Yu
BACKGROUND Functional dyspepsia (FD) refers to a group of upper gastrointestinal syndromes, subdivided into two types: postprandial distress syndrome (PDS) and epigastric pain syndrome (EPS). The etiology of FD remains unclear; however, unhealthy dietary habit is one potential underlying cause. We aim to explore the association of poor dietary habits with FD and its subtypes. MATERIAL AND METHODS A validated epidemiological questionnaire was designed to investigate dietary habits and gastrointestinal syndromes...
August 15, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28806069/oxidation-kinetics-of-bromophenols-by-nonradical-activation-of-peroxydisulfate-in-the-presence-of-carbon-nanotube-and-formation-of-brominated-polymeric-products
#3
Chao-Ting Guan, Jin Jiang, Cong-Wei Luo, Jun Ma, Su-Yan Pang, Yang Zhou, Yi Yang
This work demonstrated that bromophenols (BrPs) could be readily oxidized by peroxydisulfate (PDS) activated by a commercial carbon nanotube (CNT), while furfuryl alcohol (a chemical probe for singlet oxygen (1O2)) was quite refractory. Results obtained by radical quenching experiments, electron paramagnetic resonance spectroscopy, and Fourier transform infrared spectroscopy further confirmed the involvement of nonradical PDS-CNT complexes rather than 1O2. Bicarbonate and chloride ion exhibited negligible impacts on BrPs degradation by the PDS/CNT system, while a significant inhibitory effect was observed for natural organic matter...
August 14, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28801995/inst-ox-05-024-first-line-gemcitabine-oxaliplatin-and-erlotinib-for-primary-hepatocellular-carcinoma-and-bile-duct-cancers-a-multicenter-phase-ii-trial
#4
Yehuda Z Patt, Waheed Murad, Mohammed H Fekrazad, Ari D Baron, Pranshu Bansal, Yanis Boumber, Kim Steinberg, Sang-Joon Lee, Ed Bedrick, Ruofei Du, Fa Chyi Lee
Hepatocellular Carcinoma (HCC) incidence is increasing in the USA. Gemcitabine (G) and oxaliplatin (O) are active in HCC and biliary duct cancer (BDC). Erlotinib (E) is an EGFR tyrosine kinase inhibitor (TKI) with known activity against both. We sought to evaluate the efficacy of the combination G+O+E. Patients with either of the two diagnosis were treated in a phase II trial. Simons 2 stage design was used. A disease-control rate (DCR), complete response (CR) + partial response (PR)+ stable disease (SD) at 24 weeks of ≤20% and >40% (P0 and P1 of 0...
August 11, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28795373/implementation-of-extensive-cytoreduction-resulted-in-improved-survival-outcomes-for-patients-with-newly-diagnosed-advanced-stage-ovarian-tubal-and-peritoneal-cancers
#5
Francesco Raspagliesi, Giorgio Bogani, Antonino Ditto, Fabio Martinelli, Valentina Chiappa, Chiara Borghi, Cono Scaffa, Federica Morano, Giuseppa Maltese, Domenica Lorusso
BACKGROUND: Residual disease (RD) after primary debulking surgery (PDS) is one of the main factors driving ovarian cancer prognosis. The primary end point of this study was assessment of the impact that surgery had on survival outcomes for patients with advanced ovarian cancer. METHODS: Data on the effect of newly diagnosed advanced-stage ovarian, tubal, and peritoneal cancers were analyzed during two study periods (T1: 2001-2006 and T2: 2007-2012), in which the concepts of optimal and complete cytoreduction were introduced and implemented...
August 9, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28795233/bicarbonate-transport-during-enamel-maturation
#6
REVIEW
Kaifeng Yin, Michael L Paine
Amelogenesis (tooth enamel formation) is a biomineralization process consisting primarily of two stages (secretory stage and maturation stage) with unique features. During the secretory stage, the inner epithelium of the enamel organ (i.e., the ameloblast cells) synthesizes and secretes enamel matrix proteins (EMPs) into the enamel space. The protein-rich enamel matrix forms a highly organized architecture in a pH-neutral microenvironment. As amelogenesis transitions to maturation stage, EMPs are degraded and internalized by ameloblasts through endosomal-lysosomal pathways...
August 9, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28783816/association-of-dissemination-of-an-educational-communication-tool-with-docusate-administration
#7
Darren Pasay, Micheal Guirguis, Rhonda Shkrobot, Jeremy Slobodan, Lauren Bresee
Importance: A clear message and call to action can affect the use of a medication with limited efficacy. Objectives: To assess the association of the dissemination of an educational document about the lack of efficacy of docusate with docusate administration and whether changing docusate administration was associated with a change in administration of comparable laxatives. Design, Setting, and Participants: In this quasi-experimental, pre-post study of all acute care and continuing care facilities serviced by Alberta Health Services in Alberta, Canada, an interrupted time series analysis was performed to examine the association of an educational communication tool with docusate administration from June 1, 2014, through May 31, 2016...
August 7, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28782273/up-regulation-of-transient-receptor-potential-vanilloid-trpv-and-down-regulation-of-brain-derived-neurotrophic-factor-bdnf-expression-in-patients-with-functional-dyspepsia-fd
#8
C K Y Cheung, L L Lan, M Kyaw, A D P Mak, A Chan, Y Chan, J C Y Wu
BACKGROUND: The role of immune activation in Functional Dyspepsia (FD) patients without previous infection is unclear. We compare the gastric and circulating brain-derived neurotropic factor (BDNF), receptor potential vanilloid type (TRPV) families and various cytokines in FD patients. METHODS: Consecutive adult FD patients (Rome III) with no recent history of gastroenteritis and asymptomatic healthy controls were recruited for upper endoscopy. Subjects with GERD and IBS as predominant symptoms, diabetes mellitus, current or previous Helicobacter pylori infection, psychiatric illness and recent use of NSAID or PPI were excluded...
August 7, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28781132/-taking-training-to-the-next-level-the-american-college-of-surgeons-committee-on-residency-training-survey
#9
Richard B Damewood, Patrice Gabler Blair, Yoon Soo Park, Linda K Lupi, Rachel Williams Newman, Ajit K Sachdeva
OBJECTIVE: The American College of Surgeons (ACS) appointed a committee of leaders from the ACS, Association of Program Directors in Surgery, Accreditation Council for Graduate Medical Education, and American Board of Surgery to define key challenges facing surgery resident training programs and to explore solutions. The committee wanted to solicit the perspectives of surgery resident program directors (PDs) given their pivotal role in residency training. DESIGN: Two surveys were developed, pilot tested, and administered to PDs following Institutional Review Board approval...
August 3, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28780069/serine-protease-related-proteins-in-the-malaria-mosquito-anopheles-gambiae
#10
Xiaolong Cao, Mansi Gulati, Haobo Jiang
Insect serine proteases (SPs) and serine protease homologs (SPHs) participate in digestion, defense, development, and other physiological processes. In mosquitoes, some clip-domain SPs and SPHs (i.e. CLIPs) have been investigated for possible roles in antiparasitic responses. In a recent test aimed at improving quality of gene models in the Anopheles gambiae genome using RNA-seq data, we observed various discrepancies between gene models in AgamP4.5 and corresponding sequences selected from those modeled by Cufflinks, Trinity and Bridger...
August 2, 2017: Insect Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28774524/clinical-profiles-and-surgical-outcomes-of-adult-esotropia
#11
Mikel Mikhail, Michael Flanders
OBJECTIVE: The aim of this study was to describe the clinical features and surgical outcomes of teenage and adult patients with esotropia undergoing strabismus surgery with adjustable sutures. METHODS: Seventy-three patients were included in this retrospective, cohort study. Patients were stratified into group 1 (35 with childhood-onset esotropia [CET]) and group 2 (38 with adult-onset esophoria-tropia [EPT]). Preoperative immediate, 2-week, and 4-6-month postoperative measurements of ocular alignment, as well as fusional testing, were performed...
August 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/28768763/a-solute-binding-protein-in-the-closed-conformation-induces-atp-hydrolysis-in-a-bacterial-atp-binding-cassette-transporter-involved-in-the-import-of-alginate
#12
Ai Kaneko, Kasumi Uenishi, Yukie Maruyama, Nobuhiro Mizuno, Seiki Baba, Takashi Kumasaka, Bunzo Mikami, Kousaku Murata, Wataru Hashimoto
The Gram-negative bacterium Sphingomonas sp. A1 incorporates alginate into cells via the cell-surface pit without prior depolymerization by extracellular enzymes. Alginate import across cytoplasmic membranes thereby depends on the ATP-binding cassette (ABC) transporter AlgM1M2SS (a heterotetramer of AlgM1, AlgM2, and AlgS), which cooperates with the periplasmic solute-binding protein AlgQ1 or AlgQ2; however, several details of AlgM1M2SS-mediated alginate import are not well understood. Herein, we analyzed ATPase and transport activities of AlgM1M2SS after reconstitution into liposomes with AlgQ2 and alginate oligosaccharide substrates having different polymerization degrees (PDs)...
August 2, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28767214/light-triggered-pyroelectric-nanogenerator-based-on-a-pn-junction-for-self-powered-near-infrared-photosensing
#13
Xingfu Wang, Yejing Dai, Ruiyuan Liu, Xu He, Shuti Li, Zhong Lin Wang
A nanogenerator, as a self-powered system, can operate without an external power supply for energy harvesting, signal processing, and active sensing. Here, near-infrared (NIR) photothermal triggered pyroelectric nanogenerators based on pn-junctions are demonstrated in a p-Si/n-ZnO nanowire (NW) heterostructure for self-powered NIR photosensing. The pyroelectric-polarization potential (pyro-potential) induced within wurtzite ZnO NWs couples with the built-in electric field of the pn-junction. At the moment of turning on or off the NIR illumination, external current flow is induced by the time-varying internal electric field of the pn-heterostructure, which enables a bias-free operation of the photodetectors (PDs)...
August 8, 2017: ACS Nano
https://www.readbyqxmd.com/read/28767016/personality-disorders-and-psychological-functioning-among-latina-women-with-eating-disorders
#14
Alyssa M Minnick, Fary M Cachelin, Ramani S Durvasula
Little is known about personality disorders (PD) and comorbidities among Latinas with eating disorders (ED). The dysregulation and chronicity of PDs can complicate and augment the symptomatology of EDs. This set of analyses provides a preliminary examination of PD and psychopathology in a sample of Latina women with ED. Participants (N = 34) were administered the Structured Clinical Interview for the Diagnostic and Statistical Manual, Eating Disorders Examination, and Millon Clinical Multiaxial Inventory-III to assess personality pathology, and questionnaires (Beck Depression Inventory-II and Brief Symptom Inventory) to assess psychological functioning...
July 2017: Behavioral Medicine
https://www.readbyqxmd.com/read/28763661/the-mechanism-and-efficiency-of-mno2-activated-persulfate-process-coupled-with-electrolysis
#15
Yin Xu, Heng Lin, Yukun Li, Hui Zhang
Pure three-dimensional manganese oxides (MnO2) were successfully synthesized by a simple one-step hydrothermal process. The obtained particles were characterized via XRD, BET, SEM, XPS and FTIR techniques. To enhance the efficiency of heterogeneous catalytic process, a facile and effective electrochemical method was introduced. The degradation of C. I. Acid Orange 7 (AO7) as the target pollutant in aqueous solution by an oxidation system involving MnO2 activated peroxydisulfate (PDS) coupled with electrochemical method is reported herein...
July 27, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28763362/survival-after-primary-debulking-surgery-compared-with-neoadjuvant-chemotherapy-in-advanced-ovarian-cancer-a-national-cancer-database-study
#16
Brandon-Luke L Seagle, Stephen Graves, Anna E Strohl, Shohreh Shahabi
OBJECTIVE: The aim of this study was to compare overall survival (OS) of women with advanced ovarian cancer treated with primary debulking surgery (PDS) or neoadjuvant chemotherapy (NAC) using a large national cohort. METHODS: The 1998-2011 National Cancer Database was queried to identify women with stage III or IV ovarian cancer treated with multiagent chemotherapy and stage-appropriate surgery. Overall survival was estimated and compared using Kaplan-Meier analysis between women who received PDS followed by multiagent chemotherapy or NAC followed by interval surgery...
August 1, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28762020/conception-and-management-of-a-poorly-understood-spectrum-of-dermatologic-neoplasms-atypical-fibroxanthoma-pleomorphic-dermal-sarcoma-and-undifferentiated-pleomorphic-sarcoma
#17
REVIEW
Teo Soleymani, S Tyler Hollmig
Atypical fibroxanthoma (AFX) and pleomorphic dermal sarcoma (PDS) tumors share many clinical, etiologic, and histologic features and likely represent components of a tumor spectrum. In dermatologic oncology, differentiating between AFX and PDS is pivotal as tumors with histological features consistent with PDS are more likely to behave in a clinically aggressive manner. Importantly, the term "pleomorphic dermal sarcoma" (PDS) is a more appropriate designation than "undifferentiated pleomorphic sarcoma" (UPS) for describing deeper, more aggressive, histologically high-grade cutaneous tumors that otherwise resemble AFX...
August 2017: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/28759264/breastfeeding-education-and-support-services-provided-to-family-medicine-and-obstetrics-gynecology-residents
#18
Elizabeth Rodriguez Lien, Karen Shattuck
BACKGROUND: Breastfeeding education is known to be insufficient in pediatric (PEDS) training and is, in part, responsible for suboptimal rates of breastfeeding. No recent studies about the level of education provided to family medicine (FM) and obstetrics-gynecology (OB) residency trainees are available. OBJECTIVES: This study was conducted to investigate breastfeeding education and support services provided to FM and OB residents in the United States. The results were compared with a 2011 study of PEDS residents...
July 31, 2017: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/28758886/personality-schizophrenia-and-violence-a-longitudinal-study
#19
Valentina Candini, Marta Ghisi, Gioia Bottesi, Clarissa Ferrari, Viola Bulgari, Laura Iozzino, Maria Elena Boero, Alessandra De Francesco, Paolo Maggi, Beatrice Segalini, Vanessa Zuccalli, Gian Marco Giobbio, Giuseppe Rossi, Giovanni de Girolamo
The aims of this study were (a) to investigate the presence of clinically significant personality traits and personality disorders (PD) in patients living in residential facilities, with or without a history of violence (69 and 46, respectively); and (b) to investigate any associations between clinically significant personality traits and PDs, aggression, impulsivity, hostility, and violent behavior during a 1-year follow-up. The most frequent primary diagnoses were schizophrenia (58.3%) and PD (20.9%). Those with a history of violence demonstrated more antisocial and alcohol dependence features and lower depressive PD symptoms than the control group...
July 31, 2017: Journal of Personality Disorders
https://www.readbyqxmd.com/read/28755613/dsm-5-cannabis-use-disorder-in-the-national-epidemiologic-survey-on-alcohol-and-related-conditions-iii-gender-specific-profiles
#20
Bradley T Kerridge, Roger Pickering, Patricia Chou, Tulshi D Saha, Deborah S Hasin
OBJECTIVE: The objective of this study was to present current information on the prevalence, correlates, comorbidity and quality of life among men and women with cannabis use disorder (CUD). METHODS: In 2012-2013, 36,309 respondents ≥18years old participated in face-to-face interviews in the National Epidemiologic Survey on Alcohol and Related Conditions-III. RESULTS: Prevalence of 12-month CUD was greater among men (3.5%) than women (1...
July 14, 2017: Addictive Behaviors
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