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Leonora King, Stephanie Robins, Gang Chen, Volodymyr Yerko, Yi Zhou, Corina Nagy, Nancy Feeley, Ian Gold, Barbara Hayton, Gustavo Turecki, Phyllis Zelkowitz
The present study investigated the association of perinatal depression (PD) with differential methylation of 3 genomic regions among mother and child dyads: exon 3 within the oxytocin receptor (OXTR) gene and 2 intergenic regions (IGR) between the oxytocin (OXT) and vasopressin (AVP) genes. Maternal PD was assessed at 5 time-points during pregnancy and postpartum. Four groups were established based on Edinburgh Postnatal Depression Scale (EPDS) cut-off scores: no PD, prenatal or postpartum depressive symptoms only and persistent PD (depressive symptoms both prenatally and postpartum)...
September 13, 2017: Hormones and Behavior
Pelin Dikmen-Yildiz, Susan Ayers, Louise Phillips
OBJECTIVE: (a) to assess prevalence of depression, anxiety and post-traumatic stress disorder (PTSD) and their comorbidity among women during the perinatal period (b) to examine course of those disorders from pregnancy to 6 months postpartum (c) to determine the rates of new-onset cases at 4-6 weeks and 6 months postpartum. DESIGN: A longitudinal population-based study in which participants completed psychosocial measures of depression, anxiety and PTSD in pregnancy (n = 950), 4-6 weeks (n = 858) and 6 months (n = 829) after birth...
September 6, 2017: Midwifery
Wenhui Sun, Zesheng An, Peiyi Wu
The distinct thermal transition behavior of thermoresponsive block polymers based on poly(ethylene glycol)methyl ether acrylate (PEGA) and their corresponding disulfide-cross-linked nanogels was studied by using FTIR measurements in combination with two-dimensional correlation spectroscopy (2Dcos). Spectral analysis clearly reveals that the sharp thermal transition of the precursor polymer is accompanied by a forced hydration process induced by the formation of hydrogen bonds between the entrapped water molecules and the C[double bond, length as m-dash]O groups, while the nanogel with a relatively continuous thermal transition is related to the existence of various dehydrating states of the C[double bond, length as m-dash]O groups...
September 15, 2017: Physical Chemistry Chemical Physics: PCCP
Daniel Leising, Stefan Scherbaum, Pia Packmohr, Johannes Zimmermann
Like person judgments in everyday life, diagnoses of personality disorders (PDs) reflect at least two influences: first, the actual characteristics of the target person (substance), and second, the more positive or negative view that the perceiver has of the target person (evaluation). In this article, we present a systematic account of substance and evaluation in PD diagnoses, using a modified version of Brunswik's (1956) lens model. An empirical study shows that the items of the alternative DSM-5 model for personality disorders (AMPD) are in fact saturated with evaluation, that this evaluation is largely the same as "social desirability," and that the two mandatory components of the AMPD (criterion A and B) are not easily distinguishable from one another in that regard...
September 14, 2017: Journal of Personality Disorders
Sabine C Herpertz, Steven K Huprich, Martin Bohus, Andrew Chanen, Marianne Goodman, Lars Mehlum, Paul Moran, Giles Newton-Howes, Lori Scott, Carla Sharp
While the DSM-5 alternative model of personality disorder (PD) diagnosis allows the field to systematically compare categorical and dimensional classifications, the ICD-11 proposal suggests a radical change by restricting the classification of PDs to one category, deleting all specific types, basing clinical service provision exclusively upon a severity dimension, and restricting trait domains to secondary qualifiers without defining cutoff points. This article reflects broad international agreement about the state of PD diagnosis...
September 14, 2017: Journal of Personality Disorders
Andrea K Herndon, Jessica M Quimby, Liberty G Sieberg, Leigh Davis, Amber L Caress, Sabina Ligas, Ryan J Hansen, Luke A Wittenburg, Danial L Gustafson
Objectives The objectives were to evaluate the pharmacokinetics (PKs) of subcutaneous (SC) and intravenous (IV) dolasetron and the pharmacodynamics (PDs) of SC dolasetron in healthy cats. Methods Five cats with unremarkable complete blood count, serum biochemistry and urinalyses were utilized. In the PK study, cats received 0.8 mg/kg SC and IV dolasetron in a crossover format. Serum samples were obtained via a jugular catheter at 0, 0.25, 0.5, 1, 2, 4, 8, 12, 24, 36 and 48 h after the administration of dolasetron...
September 1, 2017: Journal of Feline Medicine and Surgery
Daniel R Witt, Gregory M Garrison, Cesar A Gonzalez, Terrence J Witt, Kurt B Angstman
BACKGROUND: Collaborative care management (CCM) is an evidence-based model that contributes to better outcomes for depression treatment in the primary care setting. Tobacco use increases overall economic costs, morbidity, and mortality and has been shown to impact behavioral health outcomes. Our study aims to observe clinical outcomes for depression treatment for patients with comorbid tobacco use and depression within the CCM model. METHODS: A retrospective chart review study of 2826 adult patients with depression enrolled in CCM was performed to determine the association between regular tobacco use and depression outcomes...
January 2017: Health Services Research and Managerial Epidemiology
Brian K Yorkgitis, Elizabeth Bryant, Desiree Raygor, Gabriel Brat, Douglas S Smink, Marie Crandall
BACKGROUND: Opioid abuse and misuse is a public health crisis. A national effort to reduce this phenomenon is ongoing. Residents represent a large pool of opioid prescribers but, are often not the target for opioid prescribing education (OPE). We developed a survey to assess current opioid prescribing practices and education among surgical residents. STUDY DESIGN: An Institutional Review Board and Association of Program Directors in Surgery approved survey was electronically mailed to surgical program directors (PDs)...
September 4, 2017: Journal of Surgical Education
Y Y Xu, L Sun, X Guo, J Zhang, X M Lou, H Wang, F B Tao
Objective: To understand the associations between overweight-obesity and puberty timing in children with different genders. Methods: The girls in grade 2, 3, 7, 8 and boys in grade 3, 4, 7, 8 were recruited from primary and middle schools in North new area of Shenyang, Yanqing district of Beijing, Erqi district of Zhengzhou and Jiulongpo district of Chongqing by purposive sampling method between October and December 2014, respectively. The information of demographic characteristics of the respondents were collected and the pubertal development status was evaluated by Pubertal Development Scale (PDS)...
September 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
Karen Dodd, Karen Watchman, Matthew P Janicki, Antonia Coppus, Claudia Gaertner, Juan Fortea, Flavia H Santos, Seth M Keller, Andre Strydom
OBJECTIVES: Post diagnostic support (PDS) has varied definitions within mainstream dementia services and different health and social care organizations, encompassing a range of supports that are offered to adults once diagnosed with dementia until death. METHOD: An international summit on intellectual disability and dementia held in Glasgow, Scotland in 2016 identified how PDS applies to adults with an intellectual disability and dementia. The Summit proposed a model that encompassed seven focal areas: post-diagnostic counseling; psychological and medical surveillance; periodic reviews and adjustments to the dementia care plan; early identification of behaviour and psychological symptoms; reviews of care practices and supports for advanced dementia and end of life; supports to carers/ support staff; and evaluation of quality of life...
September 7, 2017: Aging & Mental Health
M Govender, C Kalenga, O Mongale, T Mosasi
BACKGROUND: The first total laparoscopic pancreaticoduodenectomy was performed in 1994 by Gagner and Pomp. Their comments coupled with the inherent technical difficulties stifled development of the technique. In the last decade there has been a renewed interest in the technique with high volume centres publishing large series. We present our experience with the first operation completed at Dr George Mukhari Academic Hospital. METHOD: Pre-operative CT confirmed a resectable head of pancreas mass...
September 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
Li-Hong Yao, Liang Su, Lu Liu, Hai-Tao Sun, Jun-Jie Wang
Background: Portal-vein stent combined with one iodine-125 ((125)I) seed strand has become a new treatment for portal vein tumor thrombosis. However, dosimetric aspects of this irradiation stent have not been reported. Therefore, we aimed to undertake dosimetric analyses comparing portal-vein stents combined with different numbers of (125)I seed strands. Methods: A water cylinder was created by a treatment-planning system to simulate a portal-vein stent. The stent was combined with one, two, or three (125)I seed strands (Groups I, II, and III, respectively)...
September 20, 2017: Chinese Medical Journal
M Groth, M Ernst, P Deindl, J Herrmann
The aim of the study was to evaluate the B‑flow sonography (BFS) to image the basal cerebral arteries in newborn infants. For this purpose 34 newborns, who underwent standardized ultrasound of the brain including BFS, color Doppler (CDS) and power Doppler (PDS) techniques were retrospectively assessed. Delineation of the anterior communicating (Acom), the posterior communicating (Pcom), the middle cerebral (M1 and M2 segments), the anterior cerebral (A1 and A2 segments), and the posterior cerebral artery (P1 and P2 segments) were visually scored...
September 5, 2017: Clinical Neuroradiology
Michael V Zaretsky, Kenneth W Liechty, Henry L Galan, Nicholas J Behrendt, Shane Reeves, Ahmed I Marwan, Corbett Wilkinson, Michael Handler, Megan Lagueux, Timothy M Crombleholme
OBJECTIVE: We reviewed our experience with open fetal surgical myelomeningocele repair to assess the efficacy of a new modification of the hysterotomy closure technique regarding hysterotomy complication rates at the time of cesarean delivery. METHODS: A modification of the standard hysterotomy closure was performed on all patients undergoing prenatal myelomeningocele repair. The closure consisted of an interrupted full-thickness #0 polydioxanone (PDS) retention suture as well as a running #0 PDS suture to re-approximate the myometrial edges, and the modification was a third imbricating layer resulting in serosal-to-serosal apposition...
September 6, 2017: Fetal Diagnosis and Therapy
Annett Kahl, Andreas du Bois, Philipp Harter, Sonia Prader, Stephanie Schneider, Florian Heitz, Alexander Traut, Pier Francesco Alesina, Beate Meier, Martin Walz, Annettte Brueckner, Harald-Thomas Groeben, Violeta Brunkhorst, Sebastian Heikaus, Beyhan Ataseven
BACKGROUND: We evaluated the prognostic impact of the age-adjusted Charlson Comorbidity Index (ACCI) on both postoperative morbidity and overall survival (OS) in patients with advanced epithelial ovarian cancer (EOC) treated at a tertiary gynecologic cancer center. PATIENTS AND METHODS: Exploratory analysis of our prospectively documented tumor registry was performed. Data of all consecutive patients with stage IIIB-IV ovarian cancer who underwent primary cytoreductive surgery (PDS) from January 2000 to June 2016 were analyzed...
September 5, 2017: Annals of Surgical Oncology
Roberto Santoro, Roberto Luca Meniconi, Pasquale Lepiane, Giovanni Vennarecci, Gianluca Mascianà, Marco Colasanti, Eugenio Santoro, Giuseppe Maria Ettorre
Pancreaticoduodenectomy (PD) is associated with high postoperative morbidity. The management of postoperative complications is paramount for reducing the mortality rate. The aim of this study was to evaluate the importance of surgical and hospital experience on outcomes by comparing postoperative results in three different hospitals with increasing resources for supporting the same surgical team. Patients data and surgical outcome of 300 consecutive patients undergoing PD were collected prospectively in the department database and divided into three periods (A = 1990-2000, B = 2001-March 2007, C = April 2007-2015)...
September 1, 2017: Updates in Surgery
Kanoko Shimoji, Kimihiko Ito, Lena Tashima, Tomohiko Tsuruta, Mio Nakagawa, Yoshinori Kagawa, Yutaka Takeda, Takashi Iwata, Taro Yagi, Chihiro Odani, Hitomi Ono, Rieko Okubo, Mayako Goto, Kensuke Hori
The current standard treatment for advanced ovarian cancer is primary debulking surgery(PDS). We may expect a good prognosis if complete debulking(no visible residual tumor)is possible. However, if complete surgery is not possible owing to the location of the tumor or poor performance status, neo-adjuvant chemotherapy(NAC)could be an alternative option. Interval debulking surgery(IDS)can be planned after NAC to try and achieve complete debulking surgery. We reviewed stage III and IV epithelial ovarian cancers treated at Kansai Rosai Hospital between January 2012 and January 2016...
August 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Zhongshan Zhang, Xiaomei Wang, Huili Su, Yongliang Pan, Jianfang Han, Taisheng Zhang, Genxiang Mao
Porphyran, sulfated galactan extracted from red algae Porphyra haitanensis is a sulfated polysaccharide, which possesses excellent activities. In present study, WI-38 cells were treated with H2O2 to induce premature senescence and then the protection of porphyran against aging in vitro and associated molecular mechanisms were investigated. The protection occurred in a dose-dependent manner, offering an optimal efficacy starting at 10μg/mL. The proportion of SA-β-gal positive cells in porphyran group decreases from 53% to 23% in the cultures at 30 PDs...
August 28, 2017: International Journal of Biological Macromolecules
Chinreddy Subramanyam Reddy, Sang-Hoon Lee, Jeong Su Yoon, Jae Kwang Kim, Sang Won Lee, Mok Hur, Sung Cheol Koo, Jin Meilan, Woo Moon Lee, Jae Ki Jang, Yoonkang Hur, Sang Un Park, And Yeon Bok Kim
Ixeris dentata var. albiflora is considered as a potential therapeutic agent against mithridatism, calculous, indigestion, pneumonia, hepatitis, and tumors as well as good seasoned vegetable in Far East countries. Phytoene synthase (PSY), phytoene desaturase (PDS) ξ-carotene desaturase (ZDS), lycopene β-cyclase (LCYB), lycopene ε-cyclase (LCYE), ε-ring carotene hydroxylase (CHXB), and zeaxanthin epoxidase (ZDS) are vital enzymes in the carotenoid biosynthesis pathway. We have examined these seven genes from I...
August 31, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Steve Balsis, Evan Loehle-Conger, Alexander J Busch, Tatiana Ungredda, Thomas F Oltmanns
Individuals with borderline personality disorder (BPD) features may be unaware of or unwilling to report their own personality or maladaptive behaviors, which complicates the assessment of BPD. Informants who know the individuals with BPD features may be uniquely suited to aid in the personality assessment of these individuals. The present study analyzed the comparative ability of individuals (targets) and informants to report BPD features across the continuum of BPD severity. The sample consisted of 1387 targets, ages 55 to 65 (56% women), who were recruited for an epidemiological longitudinal study examining the effects of PDs on health and social functioning...
August 31, 2017: Personality Disorders
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