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https://www.readbyqxmd.com/read/28718942/the-shift-toward-neo-adjuvant-chemotherapy-and-interval-debulking-surgery-for-management-of-advanced-ovarian-and-related-cancers-in-a-population-based-setting-impact-on-clinical-outcomes
#1
James L Nicklin, Shaun McGrath, Lee Tripcony, Andrea Garrett, Russell Land, Amy Tang, Lewis Perrin, Naven Chetty, Nisha Jagasia, Alex J Crandon, Marcelo Nascimento, Graeme Walker, Karen Sanday, Andreas Obermair
OBJECTIVES: The aim of this study was to determine the proportion of patients with advanced ovarian and related cancers (EOC+RC), treated with neoadjuvant chemotherapy and interval debulking surgery (NACT - IDS), and to determine if there was any relationship with optimal cytoreduction rates and overall survival (OS) in a state-wide gynaecologic oncology service over time. METHODS: A retrospective review was undertaken using a population-based database of patients with stages 3 and 4 EOC+RC treated from 1982 till 2013 at the Queensland Centre for Gynaecological Cancer (QCGC)...
July 18, 2017: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28713319/neuropsychological-predictors-of-trauma-centrality-in-oif-oef-veterans
#2
Roland P Hart, Rohini Bagrodia, Nadia Rahman, Richard A Bryant, Roseann Titcombe-Parekh, Charles R Marmar, Adam D Brown
This study examined whether reduced performance on two neuropsychological tasks, cognitive flexibility and working memory, were associated with higher levels of trauma centrality. A growing body of research has shown that trauma centrality, the extent to which a person believes a potentially traumatic event has become central to their self-identity and life story, is associated with post-traumatic stress disorder (PTSD). Furthermore, PTSD is often associated with alterations in neuropsychological functioning...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28713252/effect-of-postural-control-demands-on-early-visual-evoked-potentials-during-a-subjective-visual-vertical-perception-task-in-adolescents-with-idiopathic-scoliosis
#3
Yi-Tzu Chang, Ling-Fu Meng, Chun-Ju Chang, Po-Liang Lai, Chi-Wen Lung, Jen-Suh Chern
Subjective visual vertical (SVV) judgment and standing stability were separately investigated among patients with adolescent idiopathic scoliosis (AIS). Although, one study has investigated the central mechanism of stability control in the AIS population, the relationships between SVV, decreased standing stability, and AIS have never been investigated. Through event-related potentials (ERPs), the present study examined the effect of postural control demands (PDs) on AIS central mechanisms related to SVV judgment and standing stability to elucidate the time-serial stability control process...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28703352/atpds-over-expression-in-tomato-exposing-unique-patterns-of-carotenoid-self-regulation-and-an-alternative-strategy-for-the-enhancement-of-fruit-carotenoid-content
#4
Ryan P McQuinn, Breanna Wong, James J Giovannoni
The regulation of plant carotenogenesis is an active research area for both biological discovery and practical implementation. In tomato (Solanum lycopersicum) we demonstrate additional bottlenecks exist in the poly-cis-transformation of phytoene to lycopene in the context of ripening-induced PSY1 expression and activity, and reveal phytoene desaturase (PDS), as a target for manipulation toward elevated lycopene content in maturing tomato fruit. Over-expression of Arabidopsis PDS, AtPDS, elevated PDS transcript abundance in all aerial tissues resulting in both altered carotenoid accumulation and associated pathway gene expression in a tissue-specific manner...
July 13, 2017: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/28701254/characteristics-of-older-adults-who-consume-alcohol-while-on-antidepressants
#5
Erin Ulrich, Jacqueline Vonderhaar, Allison Tenhouse
OBJECTIVES: Determine the characteristics of older Americans who self-report consuming alcohol and taking at least one antidepressant. DESIGN: This study utilized cross-sectional analyses. SETTING: The University of Michigan Health and Retirement Study and its subsurvey Prescription Drug Study (PDS). PATIENTS, PARTICIPANTS: Those who reported taking at least one antidepressant prescription medication, were 65 years of age or older, and were enrolled in Medicare or Medicaid between 2002 and 2004...
July 1, 2017: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/28701190/a-novel-algorithm-for-the-treatment-strategy-for-advanced-epithelial-ovarian-cancer-consecutive-imaging-frailty-assessment-and-diagnostic-laparoscopy
#6
Kyung Jin Eoh, Jung Won Yoon, Jung-Yun Lee, Eun Ji Nam, Sunghoon Kim, Sang Wun Kim, Young Tae Kim
BACKGROUND: This study aimed to evaluate the perioperative outcomes and prognostic impact of the consecutive steps of imaging, frailty assessment, and diagnostic laparoscopy (DLS) in patients with advanced epithelial ovarian cancer (EOC). METHODS: Patients diagnosed with EOC during 2012-2015 were analyzed retrospectively. Surgical and survival outcomes were compared between three treatment groups: patients without high tumor dissemination (HTD) who underwent primary debulking surgery (PDS group); patients with HTD who underwent DLS (DLS group); and patients with HTD diagnosed by cytological confirmation of malignancy followed by neoadjuvant chemotherapy (NACT group)...
July 12, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28698899/methodical-endoscopic-repair-of-congenital-indirect-inguinoscrotal-hernia-in-adult-male-patients-with-completely-patent-processus-vaginalis
#7
C R Berney
PURPOSE: Indirect inguinal hernia related to the presence of a patent processus vaginalis (PPV) in adult is estimated to be around 15%. Most surgeons would favor a standard anterior hernioplasty to minimize the potential risk of damaging the spermatic cord structures that are always intimately fused to the congenital peritoneal sac. This also means overlooking the potential benefit of alternative posterior techniques such as endoscopic totally extraperitoneal (TEP) repair that is known to offer faster recovery with reduced risk of developing chronic groin pain...
July 11, 2017: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/28697744/e-learning-in-graduate-medical-education-survey-of-residency-program-directors
#8
Christopher M Wittich, Anoop Agrawal, David A Cook, Andrew J Halvorsen, Jayawant N Mandrekar, Saima Chaudhry, Denise M Dupras, Amy S Oxentenko, Thomas J Beckman
BACKGROUND: E-learning-the use of Internet technologies to enhance knowledge and performance-has become a widely accepted instructional approach. Little is known about the current use of e-learning in postgraduate medical education. To determine utilization of e-learning by United States internal medicine residency programs, program director (PD) perceptions of e-learning, and associations between e-learning use and residency program characteristics. METHODS: We conducted a national survey in collaboration with the Association of Program Directors in Internal Medicine of all United States internal medicine residency programs...
July 11, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/28695660/a-randomized-placebo-controlled-trial-on-the-effects-of-menthacarin-a-proprietary-peppermint-and-caraway-oil-preparation-on-symptoms-and-quality-of-life-in-patients-with-functional-dyspepsia
#9
G Rich, A Shah, N Koloski, P Funk, B Stracke, S Köhler, G Holtmann
BACKGROUND: Functional dyspepsia (FD) is a very common condition affecting more than 10% of the population. While there is no cure, a few drugs have been found to be effective for the relief of symptoms, although most are only effective in a subgroup of patients. We assess and compare the efficacy of a fixed peppermint/caraway-oil-combination (Menthacarin) on symptoms and quality of life (QoL) in patients with FD symptoms consistent with epigastric pain syndrome (EPS) and postprandial distress syndrome (PDS)...
July 10, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28695319/acute-impact-of-selected-pyridoindole-derivatives-on-fos-expression-in-different-structures-of-the-rat-brain
#10
Romana Koprdova, Jana Osacka, Mojmir Mach, Alexander Kiss
The impacts of three pyridoindole derivatives (PDs), designated as PD144, PD143, and PD104, which have previously been shown to have antidepressant (PD144) and anxiolytic (PD143, PD104) properties, were investigated on the Fos expressions in 11 different rat brain areas, including the medial prefrontal cortex, striatum, septum, accumbens nucleus (shell, core), bed nucleus of the stria terminalis, hypothalamic paraventricular nucleus, central amygdala, locus coeruleus, dorsal raphe nucleus, and the solitary tract nucleus...
July 10, 2017: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/28694512/pet-directed-speech-draws-adult-dogs-attention-more-efficiently-than-adult-directed-speech
#11
Sarah Jeannin, Caroline Gilbert, Mathieu Amy, Gérard Leboucher
Humans speak to dogs using a special speech register called Pet-Directed Speech (PDS) which is very similar to Infant-Directed Speech (IDS) used by parents when talking to young infants. These two type of speech share prosodic features that are distinct from the typical Adult-Directed Speech (ADS): a high pitched voice and an increased pitch variation. So far, only one study has investigated the effect of PDS on dogs' attention. We video recorded 44 adult pet dogs and 19 puppies when listening to the same phrase enounced either in ADS or in PDS or in IDS...
July 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28693982/assessing-and-promoting-the-wellness-of-united-states-ophthalmology-residents-a-survey-of-program-directors
#12
Elaine M Tran, Ingrid U Scott, Melissa A Clark, Paul B Greenberg
OBJECTIVE: To report on the status of residency-based wellness initiatives in ophthalmic graduate medical education and identify strategies for promoting ophthalmology resident wellness by surveying US ophthalmology program directors (PDs). DESIGN: The PDs were each sent an e-mail containing a link to an anonymous online 15-question survey. The PDs also received a letter with the survey link and a $1 incentive. After 2 weeks, nonresponders received 2 weekly reminder e-mails and phone calls...
July 7, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28693512/a-prospective-quantitative-study-of-mental-health-act-assessments-in-england-following-the-2007-amendments-to-the-1983-act-did-the-changes-fulfill-their-promise
#13
Swaran P Singh, Moli Paul, Helen Parsons, Tom Burns, Peter Tyrer, Seena Fazel, Shoumitro Deb, Zoebia Islam, Jorun Rugkåsa, Ruchika Gajwani, Lavanya Thana, Michael J Crawford
BACKGROUND: In 2008, the Mental Health Act (MHA) 2007 amendments to the MHA 1983 were implemented in England and Wales. The amendments were intended to remove perceived obstacles to the detention of high risk patients with personality disorders (PDs), sexual deviance and learning disabilities (LDs). The AMEND study aimed to test the hypothesis that the implementation of these changes would lead to an increase in numbers or proportions of patients with these conditions who would be assessed and detained under the MHA 2007...
July 10, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28692283/largely-improved-near-infrared-silicon-photosensing-by-the-piezo-phototronic-effect
#14
Yejing Dai, Xingfu Wang, Wenbo Peng, Haiyang Zou, Ruomeng Yu, Yong Ding, Changsheng Wu, Zhong Lin Wang
Although silicon (Si) devices are the backbone of modern (opto-)electronics, infrared Si-photosensing suffers from low-efficiency due to its limitation in light-absorption. Here, we demonstrate a large improvement in the performance, equivalent to a 366-fold enhancement in photoresponsivity, of a Si-based near-infrared (NIR) photodetector (PD) by introducing the piezo-phototronic effect via a deposited CdS layer. By externally applying a -0.15‰ compressive strain to the heterojunction, carrier-dynamics modulation at the local junction can be induced by the piezoelectric polarization, and the photoresponsivity and detectivity of the PD exhibit an enhancement of two orders of magnitude, with the peak values up to 19...
July 13, 2017: ACS Nano
https://www.readbyqxmd.com/read/28688532/missed-case-feedback-and-quality-assurance-conferences-in-radiology-resident-education-a-survey-of-united-states-radiology-program-directors
#15
Anne E Gill, Philip K Wong, Mark E Mullins, Amanda S Corey, Brent P Little
RATIONALE AND OBJECTIVES: Diagnostic Radiology (DR) residents typically generate preliminary reports for imaging examinations, but few publications discuss feedback regarding missed or misinterpreted findings. Our goal was to determine the practices of United States DR residencies with respect to missed case feedback, including the role of Quality Assurance (QA) conferences. MATERIALS AND METHODS: A 23-item survey containing multiple-choice questions and several free text fields was created and hosted on SurveyMonkey(R)...
July 5, 2017: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/28687803/self-powered-zns-nanotubes-ag-nanowires-msm-uv-photodetector-with-high-on-off-ratio-and-fast-response-speed
#16
Qinwei An, Xianquan Meng, Ke Xiong, Yunlei Qiu
In this study, we design and demonstrate a novel type of self-powered UV photodetectors (PDs) using single-crystalline ZnS nanotubes (NTs) as the photodetecting layer and Ag nanowires (NWs) network as transparent electrodes. The self-powered UV PDs with asymmetric metal-semiconductor-metal (MSM) structure exhibit attractive photovoltaic characteristic at 0 V bias. Device performance analysis reveals that the as-assembled PDs have a high on/off ratio of 19173 and a fast response speed (τr = 0.09 s, τf = 0...
July 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28687510/flange-gastroenterostomy-results-in-reduction-in-delayed-gastric-emptying-after-standard-pancreatoduodenectomy-a-prospective-cohort-study
#17
Adeel S Khan, Greg Williams, Cheryl Woolsey, Jingxia Liu, Ryan C Fields, Majella Mb Doyle, William G Hawkins, Steven M Strasberg
INTRODUCTION: Delayed gastric emptying (DGE) is a common serious problem after pancreatoduodenectomy (PD). Flange gastrojejunostomy (FL-GE) is a previously described technique that creates an internal flange in a hand sewn gastroenterostomy. Results of FL-GE on incidence and severity of DGE after PD are presented. METHODS: Data were extracted from a prospective database of PD. Standard PD with antrectomy were performed -with Flange Gastroenterostomy (FL-GE) or other techniques (NonFL-GE) at a single institution...
July 4, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28684162/low-back-pain-development-differentially-influences-centre-of-pressure-regularity-following-prolonged-standing
#18
Kayla M Fewster, Kaitlin M Gallagher, Samuel H Howarth, Jack P Callaghan
Occupations requiring prolonged periods of static standing are associated with the development of low back pain (LBP). Certain individuals are susceptible to LBP development during prolonged standing (pain developers, PDs) while others are not (non-pain developers, NPDs). Linear centre of pressure (COP) measures suggest that standing balance control is negatively influenced following prolonged standing, and that PDs and NPDs may be differentially affected. The objective of this study was to determine if nonlinear standing balance control, quantified on COP, using sample entropy, is altered after 2-h of standing...
June 27, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28684136/open-innovation-towards-sharing-of-data-models-and-workflows
#19
Daniela J Conrado, Mats O Karlsson, Klaus Romero, Céline Sarr, Justin J Wilkins
Sharing of resources across organisations to support open innovation is an old idea, but which is being taken up by the scientific community at increasing speed, concerning public sharing in particular. The ability to address new questions or provide more precise answers to old questions through merged information is among the attractive features of sharing. Increased efficiency through reuse, and increased reliability of scientific findings through enhanced transparency, are expected outcomes from sharing...
July 3, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28674929/frequency-of-a-large-drift-caused-by-pressure-wire-using-optical-fibers
#20
Yoshiaki Kawase, Toru Tanigaki, Akihiro Hirakawa, Hiroyuki Omori, Tetsuo Hirata, Syuuichi Okamoto, Hideaki Ota, Jun Kikuchi, Munenori Okubo, Hiroki Kamiya, Masanori Kawasaki, Takahiko Suzuki, Hitoshi Matsuo
The frequency of a large pressure signal drift (PDs) caused by pressure wire using optical fibers and its effect on fractional flow reserve (FFR)-based decision-making is not clear. We used pressure wires using optical fibers as "workhorse wires" for 95 consecutive lesions. The wire was normalized at the tip of the guiding catheter just before performing the percutaneous coronary intervention (PCI) and was used without re-normalization until the end of the PCI. The drift value at the end of the procedures was evaluated...
July 3, 2017: Cardiovascular Intervention and Therapeutics
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