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Virginia Carvalhais, Ema Ruivães, Luis Bernardo Pina-Cabral, Bárbara Mesquita, Flávio Oliveira, Maria Céu Monteiro, Maria Begoña Criado
Endothelial and platelet dysfunction increase the atherothrombotic risk in diabetes mellitus patients. Therefore, arterial ischaemia of lower limbs is an important complication in diabetes mellitus. In the present work, type 2 diabetic patients were classified by a podiatrist into presence or absence of arterial ischaemia of lower limbs. Several polymorphisms in platelet glycoproteins and eNOS genes were evaluated. Our results suggest that the -5CC genotype in Kozak sequence of GPIbα may be associated with a higher risk of developing arterial ischaemia of lower limbs in type 2 diabetes mellitus patients...
October 26, 2016: Foot
Mathew Wooster, Adam Tanious, Shivangi Patel, Neil Moudgill, Martin Back, Murray Shames
BACKGROUND: Off-label parallel endografting (PE) has been increasingly criticized in favor of on-label custom fenestrated endografts. There remain limited direct comparisons, however, between concurrent patient populations treated by similarly experienced operators. Hence, we seek to evaluate the relative efficacy of the two techniques in treating complex aortic pathology. METHODS: All patients treated by PE or with Cook Zenith Fenestrated (Zfen) devices from January 2010 to June 2015 were reviewed, excluding those treated for rupture...
October 26, 2016: Annals of Vascular Surgery
Sara Barbiero, Alexandra Rink, Fabrizio Matteucci, David Fedele, Fabiola Paiar, Francesco Pasqualetti, Michele Avanzo
PURPOSE: To report on single-fraction stereotactic body radiotherapy (RT) (SBRT) with flattening filter (FF)-free (FFF) volumetric modulated arc therapy (VMAT) for lung cancer and to compare dosimetric results with VMAT with FF. METHODS AND MATERIALS: Overall, 25 patients were treated with 6-MV FFF VMAT (Varian TrueBeam STx LINAC) to a prescribed dose of 24Gy in a single fraction. Treatment plans were recreated using FF VMAT. Dose-volume indices, monitor units (MU), and treatment times were compared between FFF and FF VMAT techniques...
October 14, 2016: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
Kristjan Anderle, Joep Stroom, Nuno Pimentel, Carlo Greco, Marco Durante, Christian Graeff
PURPOSE: Stereotactic body image guided radiation therapy (SBRT) shows good results for lung cancer treatment. Better normal tissue sparing might be achieved with scanned carbon ion therapy (PT). Therefore an in silico trial was conducted to find potential advantages of and patients suited for PT. METHODS: For 19 patients treated with SBRT, PT plans were calculated on 4D-CTs with simulated breathing motion. Prescribed single fraction dose was 24Gy and OAR constraints used for photon planning were respected...
September 2016: Physica Medica: PM
Jong Min Park, So-Yeon Park, Hak Jae Kim, Hong-Gyun Wu, Joel Carlson, Jung-In Kim
BACKGROUND AND PURPOSE: To compare the plan quality of tri-(60)Co magnetic-resonance image-guided radiation therapy (IGRT) to that of volumetric modulated arc therapy (VMAT) for lung stereotactic ablative radiotherapy (SABR). MATERIALS AND METHODS: A total of 22 patients with lung tumors located in the lower lobe were selected retrospectively. For each patient, VMAT plans with linac and intensity-modulated radiation therapy (IMRT) plans with the tri-(60)Co system were generated with prescription doses of 60Gy (daily dose=15Gy)...
August 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Nishant Patel, Michael Santomauro, Sarah Marietti, George Chiang
PURPOSE: To describe our experience utilizing Laparoendoscopic single site (LESS) surgery in pediatric urology. MATERIALS AND METHODS: Retrospective chart review was performed on LESS urologic procedures from November 2009 through March 2013. A total of 44 patients underwent 54 procedures including: nephrectomy (23), orchiopexy (14), varicocelectomy (9), orchiectomy (2), urachal cyst excision (3), and antegrade continence enema (3) (ACE). RESULTS: Median patient age was 6...
March 2016: International Braz J Urol: Official Journal of the Brazilian Society of Urology
Fatemeh Edalati-Fard, Mojgan Mirghafourvand, Sakineh Mohammad-Alizadeh-Charandabi, Azizeh Farshbaf-Khalili
OBJECTIVE: According to the World Health Organization, depression will be the second prevalent problem after ischemic heart diseases by the year 2020. Postpartum depression (PPD) as a major depressive episode has devastating impacts on the health of mother, newborn, infant, and even the whole family. This study was conducted to investigate the relationship of zinc and magnesium serum levels with PPD, as one of the commonly assumed causes of depression. METHODS: This cross-sectional study was done on 122 postpartum women aged 18 years and more in two educational hospitals and one non-educational hospital in Tabriz-Iran, 2015...
2016: Global Journal of Health Science
Deidre L Batchelar, Hans T Chung, Andrew Loblaw, Niki Law, Thomas Cisecki, Gerard C Morton
PURPOSE: Ultrasound (US)-based planning for high-dose-rate brachytherapy allows prostate patients to be implanted, imaged, planned, and treated without changing position. This is advantageous with respect to accuracy and efficiency of treatment but is only valuable if plan quality relative to CT is maintained. This study evaluates any dosimetric impact of changing from CT- to US-based planning. METHODS AND MATERIALS: Thirty patients each were randomly selected from CT-planned and US-planned cohorts...
July 2016: Brachytherapy
Tamara A LaCouture, Jinyu Xue, Gopal Subedi, Qianyi Xu, Justin T Lee, Gregory Kubicek, Sucha O Asbell
Inconsistencies permeate the literature regarding small bowel dose tolerance limits for stereotactic body radiation therapy (SBRT) treatments. In this review, we organized these diverse published limits with MD Anderson at Cooper data into a unified framework, constructing the dose-volume histogram (DVH) Risk Map, demonstrating low-risk and high-risk SBRT dose tolerance limits for small bowel. Statistical models of clinical data from 2 institutions were used to assess the safety spectrum of doses used in the exposure of the gastrointestinal tract in SBRT; 30% of the analyzed cases had vascular endothelial growth factor inhibitors (VEGFI) or other biological agents within 2 years before or after SBRT...
April 2016: Seminars in Radiation Oncology
Marloes Duijm, W Schillemans, Joachim G Aerts, B Heijmen, Joost J Nuyttens
High radiation dose to the main bronchi can result in stenosis, occlusion or fistula formation, and death. Only 8 articles have reported side effects to the main bronchi from stereotactic body radiation therapy (SBRT), mostly with only one symptomatic complication per article. Therefore, we calculated the dose to the bronchial structures, such as trachea; mainstem bronchi; intermediate bronchus; upper-, middle-, and lower-lobe bronchus; and the segmental bronchi in 134 patients with central tumors and calculated the normal tissue complication probability (NTCP) for each of these structures, with toxicity determination based upon computed tomography imaging...
April 2016: Seminars in Radiation Oncology
Jinyu Xue, Gregory Kubicek, Ashish Patel, Benjamin Goldsmith, Sucha O Asbell, Tamara A LaCouture
Understanding dose constraints for critical structures in stereotactic body radiation therapy (SBRT) is essential to generate a plan for optimal efficacy and safety. Published dose constraints are derived by a variety of methods, including crude statistics, actuarial analysis, modeling, and simple biologically effective dose (BED) conversion. Many dose constraints reported in the literature are not consistent with each other, secondary to differences in clinical and dosimetric parameters. Application of a dose constraint without discriminating the variation of all the factors involved may result in suboptimal treatment...
April 2016: Seminars in Radiation Oncology
Chiaki Kusumoto, Shingo Ohira, Masayoshi Miyazaki, Yoshihiro Ueda, Masaru Isono, Teruki Teshima
Several reports have dealt with correlations of late rectal toxicity with rectal dose-volume histograms (DVHs) for high dose levels. There are 2 techniques to assess rectal volume for reception of a specific dose: relative-DVH (R-DVH, %) that indicates relative volume for a vertical axis, and absolute-DVH (A-DVH, cc) with its vertical axis showing absolute volume of the rectum. The parameters of DVH vary depending on the rectum delineation method, but the literature does not present any standardization of such methods...
2016: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
Seung Hwan Lee, Kyo Chul Koo, Dong Hoon Lee, Byung Ha Chung
PURPOSE: To determine whether multiparametric MRI could help predict the diagnosis of low-risk prostate cancer (PCA). METHODS: We retrospectively analyzed consecutive 623 patients with PCA who underwent multiparametric MRI before radical prostatectomy(RP). High-resolution T1- and T2-weighted, diffusion-weighted, and dynamic precontrast and postcontrast image sequences were obtained for each patient. Of the 623 patients, 177(28.4%) exhibited non visible tumors on MRI of clinical stage T1c...
December 2015: Prostate International
Javier L Arenas, Muhannad Alsyouf, Michael Jang, Kristene Myklak, Daniel Faaborg, Nazih Khater, D Duane Baldwin
OBJECTIVES: Laparoendoscopic single-site surgery (LESS) and natural orifice transluminal endoscopic surgery (NOTES) produce excellent cosmetic outcomes, but are technically challenging. The objective of this study was to test the functionality and feasibility of a novel minimally invasive surgical paradigm, which maintains triangulation but uses special externally assembled instruments to minimize the postoperative cosmetic impact. METHODS: Percutaneous Externally Assembled Laparoscopic (PEAL) instruments have specialized 2...
April 2016: Journal of Endourology
Naoya Murakami, Kazuma Kobayashi, Satoshi Nakamura, Akihisa Wakita, Hiroyuki Okamoto, Keisuke Tsuchida, Tairo Kashihara, Ken Harada, Mayuka Yamada, Shuhei Sekii, Kana Takahashi, Rei Umezawa, Koji Inaba, Yoshinori Ito, Hiroshi Igaki, Jun Itami
PURPOSE: The endobronchial brachytherapy (EBBT) is an established treatment method for tumors of the tracheobronchial system, however, little is known about the tolerance dose for organ at risk (OAR) in EBBT. The purpose of this study is to analyze patients with superficial bronchial carcinoma treated with definitive EBBT, and to investigate a relationship between late complications and dose for OAR. MATERIAL AND METHODS: Endobronchial brachytherapy was performed 6 Gy per fraction for three to four fractions with or without external beam radiation therapy (EBRT)...
October 2015: Journal of Contemporary Brachytherapy
Donghwi Park, Yoongul Oh, Ju Seok Ryu
OBJECTIVE: To identify the parameters of high-resolution manometry (HRM) with a significant correlation to abnormal findings of videofluoroscopic swallowing study (VFSS). DESIGN: Prospective study. SETTING: Hospital rehabilitation department. PARTICIPANTS: Patients with dysphagia symptoms (N=40). INTERVENTION: Participants were evaluated once using VFSS in neutral head position and evaluated twice using HRM with 5mL of thin fluid...
March 2016: Archives of Physical Medicine and Rehabilitation
Ji-Jin Yao, Guan-Qun Zhou, Li Lin, Wang-Jian Zhang, Ying-Lin Peng, Lei Chen, Ling-Long Tang, Yan-Ping Mao, Jun Ma, Ying Sun
This study is to identify significant dosimetric parameters for ear disorders in nasopharyngeal carcinoma (NPC) patients treated with intensity modulated therapy only. Ninety-seven patients with NPC were retrospectively reviewed. Organs at risk (OARs) in the auditory apparatus were contoured. Dose-volume histogram parameters were generated for the Eustachian tube (ET), tympanic cavity (TC), mastoid air cells, vestibular apparatus, cochlea and internal auditory canal (IAC). Ear disorders were rated 0 (none), 1 (mild) or 2 (severe) by a clinician blinded to radiation doses; Grade 2 ear disorders was the study end-point...
2015: Scientific Reports
E Gallitto, M Gargiulo, C Mascoli, A Freyrie, M De Matteis, C Serra, C Bianchini Massoni, G Faggioli, A Stella
OBJECTIVE: Persistent type II endoleaks (ELIIp, ≥6months) after an endovascular aneurysm repair (EVAR) can be associated with adverse outcomes. The aims of this study are the evaluation of the incidence of ELIIp, their pre-operative morphological predictive features (PMF) and the post-EVAR abdominal aortic aneurysm (AAA) evolution in the presence of ELIIp. METHODS: Patients underwent EVAR between 2008 and 2010 were prospectively collected. Cases with ELIIp (group A: AG) were identified...
July 29, 2015: Journal of Cardiovascular Surgery
Shanmugam Thirumalai Swamy, Chandrasekaran Anu Radha, Gandhi Arun, Murugesan Kathirvel, Sai Subramanian
BACKGROUND: The purpose of this study was to assess the dosimetric and clinical feasibility of volumetric modulated arc based hypofractionated stereotactic radiotherapy (RapidArc) treatment for large acoustic schwannoma (AS>10 cc). MATERIALS AND METHODS: Ten AS patients were immobilized using BrainLab mask. They were subject to multimodality imaging (magnetic resonance and computed tomography) to contour target and organs at risk (brainstem and cochlea). Volumetric modulated arc therapy (VMAT) based stereotactic plans were optimized in Eclipse (V11) treatment planning system (TPS) using progressive resolution optimizer-III and final dose calculations were performed using analytical anisotropic algorithm with 1...
2015: Asian Pacific Journal of Cancer Prevention: APJCP
P Sadeghi, R Banerjee, M Alghamdi, T Phan, A Taggar, W Smith
PURPOSE: This study quantifies errors associated with MR-guided High Dose Rate (HDR) gynecological brachytherapy. Uncertainties in this treatment results from contouring, organ motion between imaging and treatment delivery, dose calculation, and dose delivery. We focus on interobserver and inter-modality variability in contouring and the motion of organs at risk (OARs) in the time span between the MR and CT scans (∼1 hour). We report the change in organ volume and position of center of mass (CM) between the two imaging modalities...
June 2015: Medical Physics
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