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https://www.readbyqxmd.com/read/28694115/differences-in-urethral-dosimetry-between-ct-and-mr-imaging-in-multichannel-vaginal-cylinder-brachytherapy
#1
Katherine S Chen, Scott M Glaser, Hayeon Kim, Sushil Beriwal
PURPOSE: In image-based brachytherapy (IBBT), the dosimetry of small structures may be particularly sensitive to changes in contouring between imaging modalities. We therefore sought to characterize differences in urethral dosimetry in vaginal brachytherapy based on contouring on MRI vs. CT. METHODS AND MATERIALS: We retrospectively identified our most recent 15 patients treated with intracavitary brachytherapy for distal vaginal malignancies. On T2-weighted MRI, both the lumen and urethral wall were contoured...
July 7, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28669793/comparing-clinical-effects-of-photodynamic-therapy-as-a-novel-method-with-topical-corticosteroid-for-treatment-of-oral-lichen-planus
#2
Sedigheh Bakhtiari, Seyyed Masoud Mojahedi, Saranaz Azari-Marhabi, Mahshid Namdari, Zahra Elmi Rankohi
BACKGROUND: Oral lichen planus is an autoimmune disorder with several challenges in treatment. Photodynamic therapy has been proposed as a new treatment option for the disease. AIM: The present study compared the clinical effects of the photodynamic therapy and dexamethasone mouthwash in the treatment of oral lichen planus lesions. MATERIALS AND METHODS: In this randomized clinical trial, 30 patients with oral lichen planus were included.15 patients were treated with 5% methylene blue mediated photodynamic therapy using Fotosan device for 30seconds (630nm wavelength and 7...
June 29, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28476529/is-suspicious-upstaging-on-multiparametric-magnetic-resonance-imaging-useful-in-improving-the-reliability-of-prostate-cancer-research-international-active-surveillance-prias-criteria-use-of-the-k-cap-registry
#3
Sangjun Yoo, Jun Hyuk Hong, Seok-Soo Byun, Ji Youl Lee, Byung Ha Chung, Choung-Soo Kim
BACKGROUND AND OBJECTIVE: To evaluate the clinical effects of suspicious upstaging on multiparametric magnetic resonance imaging (mpMRI) for improving the quality of Prostate Cancer Research International Active Surveillance (PRIAS) criteria. MATERIAL AND METHODS: A total of 363 patients with low-risk prostate cancer (PCa) were selected from the K-CaP registry (the multicenter Korean PCa Database). Patients were divided into 2 groups according to the results of mpMRI (with or without suspicious upstaging)...
May 2, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28389510/association-of-tissue-abiraterone-levels-and-slco-genotype-with-intraprostatic-steroids-and-pathologic-response-in-men-with-high-risk-localized-prostate-cancer
#4
Elahe A Mostaghel, Eunpi Cho, Ailin Zhang, Mohammad Alyamani, Arja Kaipainen, Sean Green, Brett Marck, Nima Sharifi, Jonathan L Wright, Roman Gulati, Lawrence D True, Massimo Loda, Alvin M Matsumoto, Daniel Tamae, Trevor N Penning, Steven P Balk, Philip W Kantoff, Peter S Nelson, Mary-Ellen Taplin, Bruce Montgomery
Germline variation in solute carrier organic anion (SLCO) genes influences cellular steroid uptake and is associated with prostate cancer (PCa) outcomes. We hypothesized that, due to its steroidal structure, the CYP17A inhibitor abiraterone may undergo SLCO-mediated transport and that SLCO gene variation may influence intracellular abiraterone levels and outcomes.<br /><br />Experimental Design: Steroid and abiraterone levels were measured by mass spectrometry in serum and tissue from 58 men with localized PCa in a clinical trial of LHRH agonist plus abiraterone acetate plus prednisone for 24 weeks prior to prostatectomy...
April 7, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28342627/applicability-of-calf-subcutaneous-tissue-to-subcutaneous-injection-in-young-adults
#5
Serap Torun, Şükriye Deniz Mutluay
AIM: The aim of the study is to provide usage of subcutaneous tissue of lateral calf area (region of M. Gastrocnemius) in addition to the existing injection regions and to compare tissue thicknesses of the lateral upper arm, anterior and lateral thigh, anterior abdomen regions and calf regions. BACKGROUND: Subcutaneous injection (SC) is an application of 0.5cc drug with an injection (No. 25 and 8-15-18mm long) to the connective tissue under the skin. Individuals to which SC injection is frequently applied, should rotate the injection areas...
April 2017: Applied Nursing Research: ANR
https://www.readbyqxmd.com/read/28306550/female-pelvic-synthetic-ct-generation-based-on-joint-intensity-and-shape-analysis
#6
Lianli Liu, Shruti Jolly, Yue Cao, Karen Vineberg, Jeffrey A Fessler, James M Balter
Using MRI for radiotherapy treatment planning and image guidance is appealing as it provides superior soft tissue information over CT scans and avoids possible systematic errors introduced by aligning MR to CT images. This study presents a method that generates Synthetic CT (MRCT) volumes by performing probabilistic tissue classification of voxels from MRI data using a single imaging sequence (T1 Dixon). The intensity overlap between different tissues on MR images, a major challenge for voxel-based MRCT generation methods, is addressed by adding bone shape information to an intensity-based classification scheme...
April 21, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28292363/tonsillar-surface-micro-flora-does-it-truly-represent-pathological-tonsillar-flora
#7
Syed Nadeem Ul Haq, Zeeshan Ayub, Azeema Ahmed
OBJECTIVE: To determine the best method of identifying core tonsillar flora. STUDY DESIGN: Quasi-experimental study. PLACE AND DURATION OF STUDY: ENT Department, Combined Military Hospital, Lahore, from September 2013 to October 2015. METHODOLOGY: Eighty-seven patients of recurrent tonsillitis undergoing tonsillectomy were included. All the patients, after being anaesthetised, had surface swabs taken from the tonsillar surface followed by tonsillar aspiration with a 5cc syringe...
January 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28129972/on-the-use-of-volumetric-modulated-arc-therapy-for-single-fraction-thoracic-vertebral-metastases-stereotactic-body-radiosurgery
#8
Damodar Pokhrel, Sumit Sood, Christopher McClinton, Xinglei Shen, Rajeev Badkul, Hongyu Jiang, Matthew Mallory, Mellissa Mitchell, Fen Wang, Christopher Lominska
To retrospectively evaluate quality, efficiency, and delivery accuracy of volumetric-modulated arc therapy (VMAT) plans for single-fraction treatment of thoracic vertebral metastases using image-guided stereotactic body radiosurgery (SBRS) after RTOG 0631 dosimetric compliance criteria. After obtaining credentialing for MD Anderson spine phantom irradiation validation, 10 previously treated patients with thoracic vertebral metastases with noncoplanar hybrid arcs using 1 to 2 3D-conformal partial arcs plus 7 to 9 intensity-modulated radiation therapy beams were retrospectively re-optimized with VMAT using 3 full coplanar arcs...
April 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28048925/su-f-t-15-evaluation-of-192ir-60co-and-169yb-sources-for-high-dose-rate-prostate-brachytherapy-inverse-planning-using-an-interior-point-constraint-generation-algorithm
#9
E Mok Tsze Chung, H Safigholi, A Nicolae, M Davidson, A Ravi, D Aleman, W Song
PURPOSE: The effectiveness of using a combination of three sources, (60) Co, (192) Ir and (169) Yb, is analyzed. Different combinations are compared against a single (192) Ir source on prostate cancer cases. A novel inverse planning interior point algorithm is developed in-house to generate the treatment plans. METHODS: Thirteen prostate cancer patients are separated into two groups: Group A includes eight patients with the prostate as target volume, while group B consists of four patients with a boost nodule inside the prostate that is assigned 150% of the prescription dose...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048619/su-f-t-382-volumetric-modulated-arc-therapy-vmat-beam-angle-optimization-in-pulsed-partial-brain-irradiation-ppbi-for-newly-diagnosed-glioblastoma
#10
J Zhou, Y Wang, X Ding, J Liang, D Yan, B Marples, J Dilworth
PURPOSE: To optimize VMAT beam parameters in PPBI to minimize treatment time. We investigate the coverage and organs at risk (OR) avoidance capability of shorter arcs with shorter treatment times. METHODS: We evaluated the treatment plans for eleven previously treated PPBI patients. Each patient received 46Gy (2Gy×23) to the initial target and an additional 14Gy (2Gy×7) as a sequential boost. Each daily 2-Gy fraction was delivered as ten 0.2-Gy pulses separated by 3-minute intervals using VMAT...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048366/su-f-t-632-on-the-use-of-intensity-modulated-arc-therapy-for-thoracic-vertebral-metastases-sbrt-treatment
#11
D Pokhrel, M Mallory, R Badkul, H Jiang, H Saleh, F Wang, C Lominska
PURPOSE: To retrospectively evaluate quality, efficiency and delivery accuracy of intensity modulated arc therapy (IMAT) plans for thoracic-vertebral metastases using stereotactic body radiotherapy (SBRT). METHODS: After obtaining approval of RPC-benchmark plan, seven previously treated thoracic-vertebral metastases patients with non-coplanar hybrid arcs(NC-HA)using 1-2 3D-dynamic conformal partial-arcs plus 7-9 IMRT-beams were re-optimized with IMAT using 3 full co-planar arcs...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048271/su-f-j-128-dosimetric-impact-of-esophagus-motion-in-spine-stereotactic-body-radiotherapy
#12
J Yang, X Wang, Z Zhao, J Yang, Y Zhang, L Court, J Li, P Brown, A Ghia
PURPOSE: Acute esophageal toxicity is a common side effect in spine stereotactic body radiotherapy (SBRT). The respiratory motion may alter esophageal position from the planning scan resulting in excessive esophageal dose. Here we assessed the dosimetric impact resulting from the esophageal motion using 4DCT. METHODS: Nine patients treated to their thoracic spines in one fraction of 24 Gy were identified for this study. The original plan on a free breathing CT was copied to each phase image of a 4DCT scan, recalculated, scaled, and accumulated to the free breathing CT using deformable image registration...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048255/su-d-brb-04-nomogram-for-prediction-comparison-and-evaluation-of-dose-to-normal-tissue-in-srs-planning
#13
A Templeton, Y Liao, A Diaz, J Turian
PURPOSE: Radiosurgery of brain metastases is a unique treatment planning subset in which the treatment approach, high conformality and steep dose gradients are relatively invariant with varying location, size and shape of the target. Prescription doses are generally limited by the size of tumor or amount of surrounding normal brain receiving intermediate doses. We tabulated our treatment plans to establish a nomogram which provides planning expectations, useful for patient scheduling, planning efficiency, and training purposes...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047873/su-f-t-397-evaluating-the-impact-of-bladder-filling-status-for-the-organs-at-risk-dose-distribution-in-cervical-cancer-patients-with-intensity-modulated-radiotherapy
#14
J Y Zhang, D L Hong
PURPOSE: To investigate the impact of bladder filling status of the organs at risk (OARs) on dose distribution during intensity modulated radiotherapy (IMRT) for cervical cancer patients. METHODS: Twelve cervical cancer patients treated with IMRT were selected for this study. The prescription dose was 45Gy/25 fractions with the 6 MV photon beam. All patients performed two CT scans, one with an empty bladder, the other one with bladder filled. For the registration of two CT scans, the fusion was automatically carried out upon the bony anatomy...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047753/su-d-204-01-a-methodology-based-on-machine-learning-and-quantum-clustering-to-predict-lung-sbrt-dosimetric-endpoints-from-patient-specific-anatomic-features
#15
K Lafata, L Ren, Q Wu, C Kelsey, J Hong, J Cai, F Yin
PURPOSE: To develop a data-mining methodology based on quantum clustering and machine learning to predict expected dosimetric endpoints for lung SBRT applications based on patient-specific anatomic features. METHODS: Ninety-three patients who received lung SBRT at our clinic from 2011-2013 were retrospectively identified. Planning information was acquired for each patient, from which various features were extracted using in-house semi-automatic software. Anatomic features included tumor-to-OAR distances, tumor location, total-lung-volume, GTV and ITV...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047707/su-g-201-14-is-maximum-skin-dose-a-reliable-metric-for-accelerated-partial-breast-irradiation-with-brachytherapy
#16
S Park, O Ragab, S Patel, Y Kim, J Demanes, M Kamrava
PURPOSE: To evaluate the reliability of the maximum point dose (Dmax) to the skin surface as a dosimetric constraint, we investigated the correlation between Dmax at the skin surface and dose metrics at various definitions of skin thickness. METHODS: 42 patients treated with APBI using a Strut Adjusted Volume Implant (SAVI) applicator between 2010 and 2014 were retrospectively reviewed. Target (PTV_EVAL) and organs at risk (OARs: skin, lung, and ribs) were delineated on a CT following NSABP B-39 guidelines...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047688/su-f-t-622-comparative-analysis-of-pencil-beam-and-anisotropic-analytical-algorithm-aaa-for-stereotactic-body-radiation-therapy-sbrt-of-thoracic-spine
#17
R Badkul, W Nicolai, D Pokhrel, T Ramanjappa, H Jiang, F Wang, C Lominskac
PURPOSE: To compare the impact of Pencil Beam(PB) and Anisotropic Analytic Algorithm(AAA) dose calculation algorithms on OARs and planning target volume (PTV) in thoracic spine stereotactic body radiation therapy (SBRT). METHODS: Ten Spine SBRT patients were planned on Brainlab iPlan system using hybrid plan consisting of 1-2 non-coplanar conformal-dynamic arcs and few IMRT beams treated on NovalisTx with 6MV photon. Dose prescription varied from 20Gy to 30Gy in 5 fractions depending on the situation of the patient...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047648/su-g-tep2-08-evaluation-of-plastic-scintillator-detector-for-small-field-stereotactic-patient-specific-quality-assurance
#18
Y Qin, S Gardner, Y Huang, J Kim, N Wen, I Chetty
PURPOSE: To evaluate the performance of a commercial plastic scintillator detector (PSD) for small-field stereotactic patient-specific quality assurance using flattening-filter-free (FFF) beams. METHODS: A total of ten spherical targets (volume range:[0.03cc-2cc]) were planned using Dynamic Conformal Arc(DCA-10 plans) and Volumetric Modulated Arc Therapy(VMAT-10 plans) techniques in Eclipse(AAA v.11, 1mm dose calculation grid size). Additionally, 15 previously-treated cranial and spine SRS plans were evaluated (6 DCA, 9 VMAT, volume range:[0...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047547/su-f-t-647-linac-based-stereotactic-radiosurgery-srs-in-the-treatment-of-trigeminal-neuralgia-detailed-description-of-srs-procedural-technique-and-reported-clinical-outcomes
#19
D Pokhrel, S Sood, R Badkul, H Jiang, T Stepp, P Camarata, F Wang
PURPOSE: SRS is an effective non-invasive alternative treatment modality with minimal-toxicity used to treat patients with medically/surgically refractory trigeminal neuralgia root(TNR) or those who may not tolerate surgical intervention. We present our linac-based SRS procedure for TNR treatment and simultaneously report our clinical outcomes. METHODS: Twenty-eight TNR-patients treated with frame-based SRS at our institution (2009-2015) with a single-fraction point-dose of 60-80Gy to TNR were included in this IRB-approved study...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047111/su-f-t-611-critical-analysis-and-efficacy-of-linac-based-beam-modulator-and-cyberknife-treatment-plans-for-acoustic-neuroma-schwannoma
#20
Karrthick Kp, T Kataria, R Thiyagarajan, T Selvan, A Abhishek
PURPOSE: To study the critical analysis and efficacy of Linac and Cyberknife (CK) treatment plans for acoustic neuroma/schwannoma. METHODS: Twelve of acoustic neuroma/schwannoma patients were taken for these study that. Treatment plans were generated in Multiplan treatment planning system (TPS) for CK using 5,7.5 and 10mm diameter collimators. Target volumes were in the range of 0.280 cc to 9.256 cc. Prescription dose (Rx) ranges from 1150cGy to 1950cGy delivered over 1 to 3 Fractions...
June 2016: Medical Physics
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