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https://www.readbyqxmd.com/read/29148592/oral-anticoagulants-in-german-nursing-home-residents-drug-use-patterns-and-predictors-for-treatment-choice
#1
Kathrin Jobski, Falk Hoffmann, Stefan Herget-Rosenthal, Michael Dörks
AIMS: Information on utilization of oral anticoagulants (OACs) in nursing homes is scarce. This study aimed to (i) describe OAC use in German nursing home residents, (ii) examine factors influencing whether treatment is initiated with vitamin K antagonists (VKAs) or non-VKA oral anticoagulants (NOACs) and (iii) assess which conditions predict switching to NOAC instead of continuing VKA. METHODS: Using claims data (2010-2014), we studied a cohort of new nursing home residents aged ≥ 65 years receiving OAC...
November 17, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29122724/detection-of-new-atrial-fibrillation-in-patients-with-cardiac-implanted-electronic-devices-and-factors-associated-with-transition-to-higher-device-detected-atrial-fibrillation-burden
#2
Giuseppe Boriani, Taya V Glotzer, Paul D Ziegler, Mirko De Melis, Lorenza Mangoni di S Stefano, Milan Sepsi, Maurizio Landolina, Maurizio Lunati, Thorsten Lewalter, A John Camm
BACKGROUND: In patients with cardiac implanted electronic devices (CIEDs) detection of new atrial fibrillation (AF) is associated with an increased risk of stroke. OBJECTIVE: To characterize daily AF burden at first detection and the rate of temporal transition to higher device detected AF burden. METHODS: A pooled analysis of data from three prospective studies was analyzed and 6580 patients (mean age 68±12 years, 72% male) with no history of AF and no anticoagulants at baseline were identified...
November 6, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29122133/percutaneous-left-atrial-appendage-closure-with-the-lambre-device-for-stroke%C3%A2-prevention-in-atrial-fibrillation-a-prospective-multicenter-clinical-study
#3
He Huang, Yu Liu, Yawei Xu, Zulu Wang, Yigang Li, Kejiang Cao, Shu Zhang, Yanzong Yang, Xinchun Yang, Dejia Huang, Bo Yu, Xi Su, Liqun Wu, Congxin Huang
OBJECTIVES: The authors sought to assess the clinical outcomes of left atrial appendage (LAA) closure with the LAmbre closure system in patients with nonvalvular atrial fibrillation (NVAF). BACKGROUND: Over 90% of thrombi are located in the LAA in NVAF patients. METHODS: A prospective, multicenter study was conducted in 153 NVAF patients with CHADS2 score ≥1. RESULTS: The LAA was successfully occluded in 152 patients...
November 13, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29121723/atrial-fibrillation-and-use-of-antithrombotic-medications-in-older-people-a-population-based-study
#4
Mozhu Ding, Laura Fratiglioni, Kristina Johnell, Johan Fastbom, Maria Ljungdahl, Chengxuan Qiu
BACKGROUND: Trends in the use of antithrombotic drugs in elderly patients with atrial fibrillation (AF) are largely unknown. We estimated the prevalence of AF in an older population, and examined whether use of anticoagulant and antiplatelet drugs in older AF patients has changed over time. METHODS: Data from the population-based Swedish National study on Aging and Care in Kungsholmen (n=3363, age≥60years, 64.9% women) were used (2001-2004 and 2007-2010). AF cases were identified through 12-lead electrocardiogram, physician examinations, and patient register records (ICD-10 code I48)...
December 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29083968/effect-of-apixaban-versus-warfarin-use-on-health-care-resource-utilization-and-costs-among-elderly-patients-with-nonvalvular-atrial-fibrillation
#5
Steven Deitelzweig, Xuemei Luo, Kiran Gupta, Jeffrey Trocio, Jack Mardekian, Tammy Curtice, Melissa Lingohr-Smith, Brandy Menges, Jay Lin
BACKGROUND: The clinical trial ARISTOTLE showed that apixaban was superior to warfarin in reducing the risks of stroke and bleeding among patients with nonvalvular atrial fibrillation (NVAF). Further study of the effect of apixaban versus warfarin use on health care resource utilization (HCRU) and associated costs in the real-world setting is warranted, especially among elderly patients who are at higher risk of stroke and bleeding. OBJECTIVE: To compare HCRU and costs among elderly NVAF patients treated with apixaban versus warfarin in the United States...
November 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29069008/mortality-prediction-using-chads2-cha2ds2-vasc-r2chads2-scores-in-systolic-heart-failure-patients-with-or-without-atrial-fibrillation
#6
Yung-Lung Chen, Ching-Lan Cheng, Jin-Long Huang, Ning-I Yang, Heng-Chia Chang, Kuan-Cheng Chang, Shih-Hsien Sung, Kou-Gi Shyu, Chun-Chieh Wang, Wei-Hsian Yin, Jiunn-Lee Lin, Shyh-Ming Chen
The CHADS2, CHA2DS2-VASc, and R2CHADS2 scores are well-known predictors of stroke caused by atrial fibrillation (AF), but no studies have evaluated their use for stratifying all-cause mortality risk in patients discharged for systolic heart failure (SHF) with or without AF.This study analyzed data in the Taiwan Society of Cardiology-heart failure with reduced ejection fraction (TSOC-HFrEF) registry. These data were obtained by a prospective, multicenter, observational survey of patients treated at 21 medical centers in Taiwan after hospitalization for acute, pre-existing or new onset SHF from May, 2013 to October, 2014...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29056957/atrial-fibrillation-and-chads2-score-as-mortality-predictors-in-young-versus-elderly-patients-undergoing-coronary-angiography
#7
Nicholay Teodorovich, Michael Sraia Swissa, Yonatan Kogan, Gera Gandelman, Michael Jonas, Jacob George, Moshe Swissa
No abstract text is available yet for this article.
September 2017: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/29049919/comparison-of-cha2ds2-vasc-chads2-and-hatch-scores-for-the-prediction-of-new-onset-atrial-fibrillation-in-cancer-patients-a-nationwide-cohort-study-of-760-339-study-participants-with-competing-risk-analysis
#8
Wei-Syun Hu, Cheng-Li Lin
BACKGROUND AND AIMS: The current study was conducted to assess the ability of CHA2DS2-VASc, CHADS2 and HATCH scores in predicting new-onset atrial fibrillation (AF) among patients with cancer. METHODS: Patients with newly diagnosed cancer between 1 January, 2000 and 31 December, 2011, from the Registry for Catastrophic Illness Patient Database, were defined as the study cohort. CHA2DS2-VASc, CHADS2 and HATCH scores were used for new-onset AF prediction in these study patients, and the predictive accuracy of the scores was assessed by the receiver operating characteristics (ROC) curve...
November 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29033503/the-management-and-prognostic-factors-of-acute-coronary-syndrome-evidence-from-the-taiwan-acute-coronary-syndrome-full-spectrum-registry
#9
REVIEW
Chun-Yuan Chu, Tsung-Hsien Lin, Wen-Ter Lai
Cardiovascular disease (CVD) accounts for approximately one-third of all global deaths, and acute coronary syndrome (ACS) is the most severe form of CVD. It is of notable importance to develop ACS strategies for reducing major adverse cardiac events (MACE) and preventing complications. In the Taiwan ACS Full Spectrum Registry, 1-year mortality among patients with ST-segment elevation myocardial infarction, non ST-segment elevation myocardial infarction and unstable angina was 6.1%, 10.1%, and 6.2%, respectively...
July 2017: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/29033049/usefulness-of-chads2-and-cha2ds2-vasc-scores-for-stroke-prediction-in-patients-with-cancer-and-atrial-fibrillation
#10
Rushad Patell, Alejandra Gutierrez, Lisa Rybicki, Alok A Khorana
Stroke prediction scores have not been validated in patients with cancer and atrial fibrillation (AF). We aimed to identify unique risk factors and evaluate validity of CHADS2 and CHA2DS2-VASc scores to predict risk of stroke and mortality. A retrospective review of all patients with cancer with pre-existing AF presenting from 2008 to 2014 was performed. Outcomes included ischemic stroke and mortality. Prognostic factors were identified with Fine and Gray regression for stroke and Cox proportional hazards analysis for survival...
September 20, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29030143/impact-of-atrial-fibrillation-on-outcomes-with-motor-vehicle-accidents
#11
Kanishk Agnihotri, N V Pothineni, Paris Charilaou, Vaibhav R Vaidya, Badal Thakkar, Vishal Goyal, Sabeeda Kadavath, Nileshkumar Patel, Apurva Badheka, Peter Noseworthy, Suraj Kapa, Paul Friedman, Bernard Gersh, Hakan Paydak, Abhishek Deshmukh
BACKGROUND: We examined the effect of AF a commonly encountered arrhythmia with significant morbidity on mortality following a motor vehicle accident (MVA) related hospitalization. METHODS: The Nationwide Inpatient Sample (NIS) was queried to identify patients with AF (ICD-9 CM 427.31) and MVA (ICD-9 CM E810.0-E819.9), considered separately and together, from 2003 through 2012. Baseline characteristics were identified and multilevel mixed model multivariate analysis was employed to verify the impact of AF on in-patient mortality in survivors...
October 3, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29021855/chads2-and-modified-cha2ds2-vasc-scores-for-the-prediction-of-congestive-heart-failure-in-patients-with-nonvalvular-atrial-fibrillation
#12
Yorihiko Koeda, Takashi Komatsu, Yuki Matsuura, Hidemi Morioka, Yohei Uchimura, Yuya Taguchi, Kentaro Tanaka, Jun Kawakami, Marie Nakamura, Shuko Takahashi, Yuji Takahashi, Yujiro Naganuma, Hiroshi Endo, Tatsuro Ito, Yoshihiro Morino, Motoyuki Nakamura
BACKGROUND & PURPOSE: We have conducted a retrospective observational study to analyze the correlation between the CHADS2 score, the modified CHA2DS2-VASc (mCHA2DS2-VASc) score, and the incidence of all-cause death and congestive heart failure (CHF). METHODS: The study cohort consisted of 292 consecutive patients with nonvalvular atrial fibrillation (NVAF) admitted to our hospital from 2012 to 2014. Electronic medical records were used to confirm medical history including prior heart failure, hypertension, diabetes, stroke, and coronary disease...
October 2017: Journal of Arrhythmia
https://www.readbyqxmd.com/read/28993118/th17-treg-ratio-in-serum-predicts-onset-of-postoperative-atrial-fibrillation-after-off-pump-coronary-artery-bypass-graft-surgery
#13
Yi He, Xi Chen, Xuejun Guo, Hang Yin, Nan Ma, Min Tang, Hao Liu, Ju Mei
BACKGROUND: The aim of this study is to identify whether the balance between T helper 17 (Th17) cells and CD4(+)CD25(+)Foxp3(+) regulatory T (Treg) cells could predict the postoperative atrial fibrillation (POAF) after coronary artery bypass graft surgery (CABG). METHODS: We enrolled 88 patients from Xinhua Hospital who received off-pump CABG (OPCABG) surgery. The baseline characteristics of patients were recorded. The preoperative variables C-reactive protein (CRP) level, left atrial (LA) volume, EuroSCORE I score, CHADS2 score, and CHA2DS2-VASc score were calculated at enrolment...
September 23, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28992980/adherence-to-recommendations-of-the-therapeutic-positioning-report-about-treatment-with-oral-anticoagulants-in-elderly-patients-with-atrial-fibrillation-the-esparta-study
#14
Carmen Suárez Fernández, Jose María Mostaza, Luis Castilla Guerra, Jesus Cantero Hinojosa, Josep Maria Suriñach, Fernando Acosta de Bilbao, Juan José Tamarit, José Luis Diaz Diaz, Jose Luis Hernandez, Daniel Cazorla, Carles Ràfols
BACKGROUND AND OBJECTIVE: To evaluate the adherence to the recommendations in clinical practice performed by the Therapeutic Positioning Report (TPR) of the Spanish Agency of Medicines and Sanitary Products about the treatment with oral anticoagulants in patients aged≥75 years old with nonvalvular atrial fibrillation (NVAF) treated in Internal Medicine departments in Spain. PATIENTS AND METHODS: Observational, cross-sectional and multicenter study in which 837 patients aged≥75 years old with NVAF, with stable treatment with oral anticoagulants at least 3 months before inclusion, and that had started treatment with oral anticoagulants before the inclusion period were included...
October 6, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28990646/-clinical-profile-and-satisfaction-with-anticoagulated-treatment-in-patients-with-non-valvular-atrial-fibrillation-attended-in-internal-medicine-and-neurology-departments-of-spain
#15
(no author information available yet)
AIM: To determine the clinical profile, management of anticoagulant treatment and satisfaction related to anticoagulation in outpatients with nonvalvular atrial fibrillation attended in Neurology or Internal Medicine departments of Spain. PATIENTS AND METHODS: Cross-sectional and multicenter study, in which 1,337 outpatients were included. Patients fulfilled ACTS, SAT-Q and EQ-5D questionnaires. RESULTS: 865 patients (64.7%) were recruited from Neurology department and 472 (35...
October 16, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/28969968/efficacy-and-safety-of-rivaroxaban-in-extreme-elderly-patients-with-atrial-fibrillation-analysis-of-the-shikoku-rivaroxaban-registry-trial-srrt
#16
Shigenobu Bando, Akiyoshi Nishikado, Norikazu Hiura, Shuntaro Ikeda, Akiyoshi Kakutani, Katsuhito Yamamoto, Noriyoshi Kaname, Masahiko Fukatani, Yuichiro Takagi, Kazushi Yukiiri, Yamato Fukuda, Yutaka Nakaya
BACKGROUND: The Shikoku Rivaroxaban Registry Trial (SRRT) is a retrospective survey of the use of rivaroxaban for stroke prevention in elderly patients in Shikoku, Japan. METHODS: The SRRT enrolled 1339 patients from 8 hospitals. Patients were divided into two groups according to their age, the extreme elderly group (453 patients aged ≧80 years) and the control group (886 patients aged <80 years). RESULTS: In the extreme elderly group, 41...
September 29, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/28966115/elective-cardioversion-in-the-era-of-novel-oral-anticoagulants-does-a-nurse-administered-verbal-questionnaire-for-compliance-negate-the-need-for-routine-transoesophageal-echocardiography
#17
Matthew K Rowe, Naomi Lollback, Leanne Slater, John Hill, Paul A Gould, Gerald C Kaye
BACKGROUND: Anticoagulation prior to elective external direct current cardioversion (EDCCV) is mandatory. The inability to monitor compliance with novel oral anticoagulants (NOACs) raises a potential safety issue. We aimed to evaluate whether a structured, nurse-led assessment of compliance prior to EDCCV ensures safety without the need for routine transoesophageal echocardiography (TOE). METHODS: Data was prospectively collected on consecutive patients undergoing EDCCV during 2014-2015...
September 12, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28952167/effect-of-atrial-fibrillation-duration-on-plasma-von-willebrand-factor-level
#18
Waldemar E Wysokinski, Kevin P Cohoon, Ewa A Konik, Rowlens M Melduni, Naser M Ammash, Samuel J Asirvatham, Robert D McBane
AIMS: Von Willebrand factor (VWF) is an independent risk factor for adverse events in patients with non-valvular atrial fibrillation (NVAF). However, it is unclear if VWF level remains elevated and predictive of stroke during entire course of NVAF. METHODS AND RESULTS: In order to determine if VWF is a time-dependent blood variable, VWF antigen measured by latex immunoassay in 425 NVAF patients and 100 controls with normal sinus rhythm (NSR) were analyzed according to NVAF duration (< 1 month: n=76, 1-12 months: n=98, and >12 months: n=251)...
September 26, 2017: European Journal of Haematology
https://www.readbyqxmd.com/read/28943575/comparison-of-the-chads2-cha2ds2-vasc-and-r2chads2-scores-in-japanese-patients-with-non-valvular-paroxysmal-atrial-fibrillation-not-receiving-anticoagulation-therapy
#19
Reisuke Yoshizawa, Takashi Komatsu, Fusanori Kunugita, Mahito Ozawa, Shingen Ohwada, Yoshihiro Satoh, Yoshihiro Morino, Motoyuki Nakamura
Objective It remains unclear whether the CHADS2, CHA2DS2-VASc, or R2CHADS2 score is the most useful for the risk stratification of ischemic stroke/systemic thromboembolism (IS/SE) in Japanese patients with paroxysmal non-valvular atrial fibrillation (PNVAF). Methods and Results We investigated the incidence of IS/SE on the basis of the CHADS2, CHA2DS2-VASc, and R2CHADS2 scores in 332 consecutive PNVAF patients (224 men, mean age: 65±13 years) who had not been administered anticoagulation therapy but who were administered antiarrhythmic drug therapy to maintain sinus rhythm between August 1995 and July 2008 before the 2008 Japanese Circulation Society guideline was issued (mean follow-up period: 53±35 months)...
September 25, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28939672/cha2ds2-vasc-score-for-identifying-truly-low-risk-atrial-fibrillation-for-stroke-a-korean-nationwide-cohort-study
#20
Tae-Hoon Kim, Pil-Sung Yang, Daehoon Kim, Hee Tae Yu, Jae-Sun Uhm, Jong-Youn Kim, Hui-Nam Pak, Moon-Hyoung Lee, Boyoung Joung, Gregory Y H Lip
BACKGROUND AND PURPOSE: As the threshold of stroke risk for initiating oral anticoagulants is lowered after the introduction of the nonvitamin K antagonist oral anticoagulants, the focus of stroke prevention in patients with nonvalvular atrial fibrillation has shifted away from predicting high-risk patients toward initially identifying patients with a truly low risk of ischemic stroke, who do not need antithrombotic therapy. We tested the predictive ability of the congestive heart failure, hypertension, age ≥75, diabetes mellitus, prior stroke or transient ischemic attack (doubled; CHADS2), congestive heart failure, hypertension, age ≥75 (doubled), diabetes mellitus, prior stroke or transient ischemic attack (doubled), vascular disease, age 65 to 74, female (CHA2DS2-VASc), and Anticoagulation and Risk Factors in Atrial Fibrillation (ATRIA) risk stratification schemes in oral anticoagulants naive patients with atrial fibrillation in a Korean nationwide sample cohort...
November 2017: Stroke; a Journal of Cerebral Circulation
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