Leo Wang, Angela Taravella Oill, M Blanchard, Melody Wu, Jonathan Hibbard, Sean Sepulveda, Lance Peter, Julie Kilpatrick, Margarita Munoz, Tracey Stiller, Noah Shulkin, Jamie Wagner, Ally Dolatabadi, Monica Nisis, Jennifer Shepphird, Gabriela Sanchez, Chetan Lingaraju, Mishika Manchanda, Heini Natri, Léonce Kouakanou, Grace Sun, Cheryl Oliver-Cervantes, Joseph Georges, Maryam Aftabizadeh, Stephen Forman, Saul Priceman, Julie Ressler, Leonidas Arvanitis, Jennifer Cotter, Massimo D'Apuzzo, Benita Tamrazi, Behnam Badie, Tom Davidson, Nicholas Banovich, Christine Brown
Outcomes for pediatric brain tumor patients remain poor, and there is optimism that chimeric antigen receptor (CAR) T cell therapy can improve prognosis. Here, we present interim results from the first six pediatric patients treated on an ongoing phase I clinical trial (NCT04510051) of IL13BBζ-CAR T cells delivered weekly into the lateral cerebral ventricles, identifying clonal expansion of endogenous CAR-negative CD8 + T cells in the cerebrospinal fluid (CSF) over time. Additionally, of the five patients evaluable for disease response, three experienced transient radiographic and/or clinical benefit not meeting protocol criteria for response...
October 23, 2023: Research Square