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Subepithelial tumor

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https://www.readbyqxmd.com/read/27878477/paraneoplastic-pemphigus-and-autoimmune-blistering-diseases-associated-with-neoplasm-characteristics-diagnosis-associated-neoplasms-proposed-pathogenesis-treatment
#1
REVIEW
Saritha Kartan, Vivian Y Shi, Ashley K Clark, Lawrence S Chan
Autoimmune paraneoplastic and neoplasm-associated skin syndromes are characterized by autoimmune-mediated cutaneous lesions in the presence of a neoplasm. The identification of these syndromes provides information about the underlying tumor, systemic symptoms, and debilitating complications. The recognition of these syndromes is particularly helpful in cases of skin lesions presenting as the first sign of the malignancy, and the underlying malignancy can be treated in a timely manner. Autoimmune paraneoplastic and neoplasm-associated bullous skin syndromes are characterized by blister formation due to an autoimmune response to components of the epidermis or basement membrane in the context of a neoplasm...
November 22, 2016: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/27858880/endoscopic-ultrasound-without-tissue-acquisition-has-poor-accuracy-for-diagnosing-gastric-subepithelial-tumors
#2
Tae Won Lim, Cheol Woong Choi, Dae Hwan Kang, Hyung Wook Kim, Su Bum Park, Su Jin Kim
Incidental gastric subepithelial tumor (SET) is frequently found during endoscopy. Although endoscopic ultrasonography (EUS) can provide useful information, its diagnostic accuracy varies. Most of the potentially malignant tumors observed on EUS are hypoechoic lesions. Therefore, we aimed to investigate the diagnostic accuracy of EUS for hypoechoic lesions located in the submucosa or proper muscle layer. We also evaluated various characteristics for potential associations with diagnostic accuracy.A retrospective review was conducted of the medical records of 99 patients who were diagnosed with gastric SET and who underwent EUS with pathologic confirmation between March 2008 and April 2015...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27824024/ultrasound-contrast-agents
#3
REVIEW
Andre Ignee, Nathan S S Atkinson, Gudrun Schuessler, Christoph F Dietrich
Endoscopic ultrasound (EUS) plays an important role in imaging of the mediastinum and abdominal organs. Since the introduction of US contrast agents (UCA) for transabdominal US, attempts have been made to apply contrast-enhanced US techniques also to EUS. Since 2003, specific contrast-enhanced imaging was possible using EUS. Important studies have been published regarding contrast-enhanced EUS and the characterization of focal pancreatic lesions, lymph nodes, and subepithelial tumors. In this manuscript, we describe the relevant UCA, their application, and specific image acquisition as well as the principles of image tissue characterization using contrast-enhanced EUS...
November 8, 2016: Endoscopic Ultrasound
https://www.readbyqxmd.com/read/27780946/-a-case-of-cecal-endometriosis-presenting-as-subepithelial-tumor
#4
Min Sik Hwang, Young Don Kim, Sa Young Shin, Jae Hyuck Jun, Jong Sam Hong, Dae Woon Eom, Gab Jin Cheon
Endometriosis is a benign gynecologic disease, characterized by the presence and growth of functional endometrial-like tissue outside uterus. This ectopic endometrial tissue is most commonly found in the peritoneum, ovaries and uterosacral ligaments, but extremely rarely there is involvement of the appendix or cecum. Here we report a case of cecal endometriosis presenting as a subepithelial tumor diagnosed by surgical excision.
October 25, 2016: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/27780945/endoscopic-resection-of-a-giant-esophageal-lipoma-causing-sudden-choking
#5
Dong Ho Jo, Hyung Ku Chon, Sun Ho Woo, Tae Hyeon Kim
Most esophageal lipomas are discovered incidentally and are small and asymptomatic. However, large (>4 cm) lipomas may cause various symptoms, including dysphagia, regurgitation, or epigastric discomfort. We present a 45-year-old woman with intermittent sudden choking and globus pharyngeus. Upper gastrointestinal endoscopy and endoscopic ultrasound revealed an approximately 10.0×1.5 cm pedunculated subepithelial tumor in the upper esophagus, identified as the cause of her symptoms. A thoracic computed tomography scan revealed a fat attenuated longitudinal mass along the upper esophagus, suggestive of a lipoma...
October 25, 2016: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/27752408/esophageal-granular-cell-tumor-a-case-report-and-review-of-literature
#6
Nishitha Thumallapally, Uroosa Ibrahim, Mayurathan Kesavan, Qing Chang, Lynne Opitz, Meekoo Dhar, Sherif Andrawes
Granular cell tumors (GCTs) are soft tissue neoplasms that originate from Schwann cells. They occur predominantly in the oral cavity, skin, and breast tissues. Gastrointestinal GCTs are very rare, accounting for only eight percent of all GCTs, most of which are located in the esophagus. Endoscopic ultrasound has been a breakthrough in diagnosing GCTs because it provides precise information on the depth of tumor invasion, thus narrowing the differential diagnosis of subepithelial lesions in the esophagus. However, the definitive diagnosis requires histological confirmation of the lesion...
September 14, 2016: Curēus
https://www.readbyqxmd.com/read/27744661/endoscopic-ultrasonography-in-the-diagnosis-of-gastric-subepithelial-lesions
#7
Eun Jeong Gong, Do Hoon Kim
Subepithelial lesions occasionally found in the stomach of patients undergoing endoscopy may be either benign lesions or tumors with malignant potential. They may also appear due to extrinsic compression. Discrimination of gastric subepithelial lesions begins with meticulous endoscopic examination for size, shape, color, mobility, consistency, and appearance of the overlying mucosa. Accurate diagnosis can be achieved with endoscopic ultrasonography, which provides useful information on the exact size, layer-of-origin, and characteristic morphologic features to support a definitive diagnosis...
September 2016: Clinical Endoscopy
https://www.readbyqxmd.com/read/27709855/using-forceps-biopsy-after-small-submucosal-dissection-in-the-diagnosis-of-gastric-subepithelial-tumors
#8
Yoon Suk Jung, Hyuk Lee, Kyungeun Kim, Jin Hee Sohn, Hong Joo Kim, Jung Ho Park
The current tissue sampling techniques for subepithelial tumors (SETs) of the gastrointestinal (GI) tract have limited diagnostic efficacy. We evaluated the diagnostic yield and safety of forceps biopsies after small endoscopic submucosal dissection (SESD biopsies) in the diagnosis of gastric SETs. A total of 42 patients with gastric SETs > 10 mm were prospectively enrolled between May 2013 and October 2014. A dual knife was used to incise the mucosa and submucosa and forceps biopsies were then introduced deep into the lesion...
November 2016: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/27671744/submucosal-tunneling-endoscopic-resection-using-methylene-blue-guidance-for-cardial-subepithelial-tumors-originating-from-the-muscularis-propria-layer
#9
Xin-Li Mao, Li-Ping Ye, Hai-Hong Zheng, Xian-Bin Zhou, Lin-Hong Zhu, Yu Zhang
Submucosal tunneling endoscopic resection (STER) of subepithelial tumors (SETs) originating from the muscularis propria (MP) layer in the cardia is rarely performed due to the difficulty of creating a submucosal tunnel for resection. The aim of this study was to evaluate the feasibility of STER using methylene-blue guidance for SETs originating from the MP layer in the cardia. From January 2012 to December 2014, 56 patients with SETs originating from the MP layer in the cardia were treated with STER using methylene-blue guidance...
September 26, 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/27666766/immunohistochemical-analysis-of-the-novel-marginal-zone-b-cell-marker-irta1-in-malignant-lymphoma
#10
Jun-Ichiro Ikeda, Masaharu Kohara, Yoko Tsuruta, Satoshi Nojima, Shinichiro Tahara, Kenji Ohshima, Masako Kurashige, Naoki Wada, Eiichi Morii
Marginal zone lymphoma (MZL) is a low-grade B-cell lymphoma derived from marginal-zone B cells. Because of a lack of specific immunohistochemical markers, MZL is mainly diagnosed based on the cytological appearance and growth pattern of the tumor. Marginal-zone B cells were recently shown to selectively express immunoglobulin superfamily receptor translocation-associated 1 (IRTA1), but the antibody used in that study is not commercially available. We therefore investigated the IRTA1 expression in non-neoplastic lymphoid tissues and 261 malignant lymphomas, examining the ability of a commercially available antibody to accurately diagnose MZL...
September 22, 2016: Human Pathology
https://www.readbyqxmd.com/read/27665176/crohn-s-disease-associated-mucosal-factors-regulate-the-expression-of-tnf-like-cytokine-1a-and-its-receptors-in-primary-subepithelial-intestinal-myofibroblasts-and-intestinal-epithelial-cells
#11
Giorgos Bamias, Eirini Filidou, Dimitris Goukos, Vasilis Valatas, Konstantinos Arvanitidis, Maria Panagopoulou, Georgios Kouklakis, George L Daikos, Spiros D Ladas, George Kolios
Intestinal subepithelial myofibroblasts (SEMFs) exert a profibrotic role in Crohn's disease (CD). Tumor necrosis factor-like cytokine 1A (TL1A) and its receptors, death-domain receptor 3 (DR3) and decoy receptor 3 (DcR3), are mucosal factors with significant involvement in experimental inflammation and CD. We aimed to determine the regulation of expression of this system of proteins in SEMFs and intestinal epithelial cells. The relative amount of mRNA transcripts for TL1A, DR3, and DcR3 was measured by real-time reverse transcription polymerase chain reaction in cultured primary SEMFs, colonic myofibroblast cell line 18CO, and epithelial cell line HT29...
September 7, 2016: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/27663715/endoscopic-submucosal-resection-of-gastric-subepithelial-lesions-smaller-than-20%C3%A2-mm-a-comparison-of-saline-solution-assisted-snare-and-cap-band-mucosectomy-techniques
#12
Cetin Karaca, Ebubekir S Daglilar, Ozlem Mutluay Soyer, Mine Gulluoglu, William R Brugge
BACKGROUND AND AIMS: Application of endoscopic submucosal resection (ESMR) in the management of gastric subepithelial lesions (GSLs) less than 20 mm is gradually increasing because it allows diagnosis and treatment at the same operative session. In this study, we compare and evaluate the benefits of ESMR with an endoscopic cap band mucosectomy technique or saline solution-assisted snare technique in GSLs smaller than 20 mm. METHODS: This was a retrospective analysis of a prospectively maintained database used at 2 academic tertiary care centers...
September 20, 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27579190/endoscopic-resection-of-a-pedunculated-brunner-s-gland-hamartoma-of-the-duodenum
#13
Masaya Iwamuro, Takehiro Tanaka, Satoko Ando, Tatsuhiro Gotoda, Hiromitsu Kanzaki, Seiji Kawano, Yoshiro Kawahara, Hiroyuki Okada
A 68-year-old Japanese woman presented with a solitary pedunculated polyp in the duodenum. Endoscopic ultrasonography showed multiple cystic structures in the polyp. The polyp was successfully resected by endoscopic snare polypectomy and pathologically diagnosed as Brunner's gland hamartoma. Because hamartomatous components were not identified in the stalk of the polyp, we speculate that the stalk developed from traction of the normal duodenal mucosa. When a solitary, pedunculated polyp with cystic structure within the submucosa is found in the duodenum, Brunner's gland hamartoma should be considered in the differential diagnosis, despite the rarity of the disease...
2016: Case Reports in Gastrointestinal Medicine
https://www.readbyqxmd.com/read/27569858/over-the-scope-clip-assisted-endoscopic-full-thickness-resection-of-epithelial-and-subepithelial-gi-lesions
#14
Badr Al-Bawardy, Elizabeth Rajan, Louis M Wong Kee Song
BACKGROUND AND AIMS: Endoscopic full-thickness resection (EFTR) allows for definitive diagnosis and treatment of select subepithelial and epithelial lesions unsuitable to conventional resection techniques. Our aim was to evaluate the efficacy and safety of over-the-scope (OTS) clip-assisted EFTR for these lesions. METHODS: Patients who underwent OTS clip-assisted EFTR between June 2014 and October 2015 were analyzed. The procedure involved (1) thermal marking of the periphery of the lesion; (2) lesion suction into the cap of either an OTSC (Ovesco Endoscopy AG, Tübingen, Germany) or Padlock clip (Aponos Medical Corp, Kingston, NH, USA) with or without triprong anchor retraction of the lesion; (3) clip deployment; and (4) en bloc resection of the lesion above the clip using an electrosurgical snare and/or knife...
August 26, 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27569353/-angiomyolipoma-with-epithelial-cysts-amlec-of-the-kidney
#15
Kazushiro Takei, Shinichi Shimizu, Yoshiro Otsuki
A 49-year-old man was demonstrated to have two tumors in the right kidney by computed tomographic scan during an examination for cholelithiasis. One was a fat rich solid tumor which was clinically diagnosed as angiomyolipoma, and the other was an unconfirmed cystic tumor. Cholecystectomy and radical nephrectomy were performed. Based on pathological findings, the solid tumor was diagnosed as common angiomyolipoma and the cystic tumor as angiomyolipoma with epithelial cysts (AMLEC). The cystic tumor consisted of 3 components : an epithelial cyst lined with single flat to cuboidal cells, a subepithelial compact stroma and an external layer of muscle predominant angiomyolipoma...
July 2016: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/27553800/endoscopic-resection-for-duodenal-subepithelial-tumors-a-single-center-experience
#16
Tae Wook Kim, Gwang Ha Kim, Do Youn Park, Sangjeong Ahn, Won Lim, Bon Eun Lee, Geun Am Song
BACKGROUND: Subepithelial tumors (SETs) in the gastrointestinal tract are often incidentally found during endoscopic examinations. Although the utility and safety of endoscopic resection (ER) of SETs in the esophagus and stomach have been described, data about the ER of duodenal SETs remain scant. Therefore, we aimed to investigate the clinical outcomes associated with the ER of duodenal SETs and to assess possible predictive factors for incomplete resection. METHODS: We conducted a retrospective observational study of 62 patients (64 lesions) that underwent ER of duodenal SETs between June 2005 and December 2015 at the Pusan National University Hospital...
August 23, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27531871/development-and-validation-of-raman-spectroscopic-classification-models-to-discriminate-tongue-squamous-cell-carcinoma-from-non-tumorous-tissue
#17
Froukje L J Cals, Senada Koljenović, José A Hardillo, Robert J Baatenburg de Jong, Tom C Bakker Schut, Gerwin J Puppels
BACKGROUND: Currently, up to 85% of the oral resection specimens have inadequate resection margins, of which the majority is located in the deeper soft tissue layers. The prognosis of patients with oral cavity squamous cell carcinoma (OCSCC) of the tongue is negatively affected by these inadequate surgical resections. Raman spectroscopy, an optical technique, can potentially be used for intra-operative evaluation of resection margins. OBJECTIVE: To develop in vitro Raman spectroscopy-based tissue classification models that discriminate OCSCC of the tongue from (subepithelial) non-tumorous tissue...
September 2016: Oral Oncology
https://www.readbyqxmd.com/read/27515839/multidimensional-vocal-assessment-after-laser-treatment-for-recurrent-respiratory-papillomatosis
#18
Takeyuki Kono, Haruna Yabe, Kosuke Uno, Koichiro Saito, Kaoru Ogawa
OBJECTIVES/HYPOTHESIS: Recurrent respiratory papillomatosis (RRP) is a benign epithelial tumor that exhibits a high frequency of recurrence. This study assesses the vocal function after laser treatment for RRP, particularly in relation to the frequency of surgery. STUDY DESIGN: Retrospective study. METHODS: Thirty RRP patients who underwent laser surgery that controlled the tumor were included. Preoperative and postoperative Grade, Roughness, Breathiness, Asthenia, and Strain Scale, videostroboscopic findings, aerodynamic and acoustic parameters, and self-assessment questionnaires were measured and compared with an age- and sex-matched control group...
August 12, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27448050/laparoscopy-assisted-endoscopic-full-thickness-resection-of-gastric-subepithelial-tumors-using-a-nonexposure-technique
#19
Osamu Goto, Hiroya Takeuchi, Motoki Sasaki, Hirofumi Kawakubo, Teppei Akimoto, Ai Fujimoto, Yasutoshi Ochiai, Tadateru Maehata, Toshihiro Nishizawa, Yuko Kitagawa, Naohisa Yahagi
Background and study aims: To avoid bacterial contamination and tumor seeding during gastrectomy surgery, we developed a nonexposure technique for endoscopic full-thickness resection with laparoscopic assistance. The feasibility and safety of nonexposed endoscopic wall-inversion surgery (NEWS) for gastric subepithelial tumors (SETs) were investigated. Patients and methods: For protruding gastric SETs ≤ 3 cm in diameter, NEWS was performed in the following sequence: laparoscopic seromuscular incision after endoscopic submucosal injection, laparoscopic seromuscular suturing with the lesion inverted, endoscopic mucosal and submucosal incision, and transoral retrieval...
July 22, 2016: Endoscopy
https://www.readbyqxmd.com/read/27443624/-solitary-neurofibroma-of-the-sigmoid-colon-presenting-as-a-subepithelial-tumor-successfully-removed-by-endoscopic-resection
#20
Won Jik Lee, Sung Min Park, Byung Wook Kim, Joon Sung Kim, Jeong Seon Ji, Hwang Choi
Neurofibromas are benign, slow-growing nerve sheath tumors of the peripheral nervous system, arising from Schwann cells, and classically associated with neurofibromatosis type 1 (Nf1, von Recklinghausen's disease). They occur rarely in the gastro-intestinal tract as isolated neoplasms, outside the classical clinical feature of neurofibromatosis. We herein present an isolated colonic neurofibroma without any systemic signs of neurofibromatosis. A 59-year-old female came to our hospital for constipation. On physical examination, general appearance showed no definite skin lesions...
July 25, 2016: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
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