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https://www.readbyqxmd.com/read/29923997/euglycemic-diabetic-ketoacidosis-caused-by-dapagliflozin-a-case-report
#1
Yu-Mou Chou, Chen-June Seak, Zhong Ning Leonard Goh, Joanna Chen-Yeen Seak, Chen-Ken Seak, Chih-Chuan Lin
RATIONALE: Diabetic ketoacidosis is a serious and potentially life-threatening acute complication of diabetes mellitus (DM). Euglycemic diabetic ketoacidosis (eDKA) is however challenging to identify in the emergency department (ED) due to absence of marked hyperglycemia, often leading to delayed diagnosis and treatment. eDKA has been recently found to be associated with sodium-glucose cotransporter 2 (SGLT2) inhibitors, one of the newest classes of antidiabetics, though there are very limited reports implicating dapagliflozin as the offending agent in ED patients...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29922394/effects-of-single-versus-multiple-bouts-of-resistance-training-on-maximal-strength-and-anaerobic-performance
#2
Kai Shiau, Te Hung Tsao, Chang Bin Yang
This study examined the effects of one single bout daily versus triple bouts of resistance exercise for 12 weeks on muscular strength and anaerobic performance of the upper body. Twenty young male adults (age: 22.0 ± 1.0 years, bench press: 44.0 ± 10.3 kg) were randomly assigned to a single bout (SB) or triple bouts (TB) of resistance exercise group. Maximal strength and anaerobic performance of the upper body using the bench press (one-repetition maximum) and the modified 30 s Wingate test were determined before and after the intervention...
June 2018: Journal of Human Kinetics
https://www.readbyqxmd.com/read/29921483/melatonin-attenuates-chronic-immobilization-stress-induced-muscle-atrophy-in-rats-influence-on-lactate-to-pyruvate-ratios-and-na-k-atpase-activity
#3
Eman S H Abd Allah, Ahmed M Mahmoud
This study assessed the protective effect of melatonin against muscle atrophy provoked by chronic immobilization stress (CIS). CIS was induced in rats by limiting their trunk movement for 90 min daily for 6 weeks. Rats subjected to the CIS procedure demonstrated a substantial decrease in body weight, an increase in serum corticosterone, muscle atrophy, and an increase in atrogin-1 mRNA levels. An increase in the serum lactate-to-pyruvate ratio and the oxidative stress accompanied by a reduction of Na+ /K+ ATPase activity could be responsible for these changes...
June 16, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/29921225/effects-of-acute-ethanol-intoxication-in-an-ovine-peritonitis-model
#4
Koji Hosokawa, Fuhong Su, Fabio Silvio Taccone, Emiel Hendrik Post, Jacques Creteur, Jean-Louis Vincent
BACKGROUND: Acute ethanol intoxication has been shown to have contrasting effects on outcomes in sepsis. The aim of this study was to explore the effects of acute ethanol intoxication on hemodynamics, renal function, brain perfusion and lactate/pyruvate in an ovine sepsis model. METHODS: Anesthetized, mechanically ventilated female sheep were randomized to an ethanol group (n = 7), which received 1 g/kg ethanol diluted in intravenous (i.v.) saline infusion or a control group (n = 7), which received the same volume of i...
June 19, 2018: BMC Anesthesiology
https://www.readbyqxmd.com/read/29921035/metabolic-flexibility-of-a-prospective-bioremediator-desulfitobacterium-hafniense-y51-challenged-in-chemostats
#5
Sviatlana Marozava, Raquel Vargas-López, Ye Tian, Juliane Merl-Pham, Martin Braster, Rainer U Meckenstock, Hauke Smidt, Wilfred F M Röling, Hans V Westerhoff
Desulfitobacterium hafniense Y51 has been widely used in investigations of perchloroethylene (PCE) biodegradation, but limited information exists on its other physiological capabilities. We investigated how D. hafniense Y51 confronts the debilitating limitations of not having enough electron donor (lactate), or electron acceptor (fumarate) during cultivation in chemostats. The residual concentrations of the substrates supplied in excess were much lower than expected. Transcriptomics, proteomics, and fluxomics were integrated to investigate how this phenomenon was regulated...
June 19, 2018: Environmental Microbiology
https://www.readbyqxmd.com/read/29920566/clinical-characteristics-and-prognostic-significance-of-eber-positivity-in-diffuse-large-b-cell-lymphoma-a-meta-analysis
#6
Xiaojuan Gao, Jia Li, Yaqi Wang, Shuai Liu, Baohong Yue
Recent studies show that Epstein-Barr virus (EBV) positivity might be related to adverse prognosis in patients with diffuse large B-cell lymphoma (DLBCL), but the results are still inconclusive. We conducted this meta-analysis to define the clinical value of EBV infection in DLBCL. All potential articles in PubMed, Web of Science, Medline, and Embase were retrieved. Using the random-effects or fixed-effect model, pooled hazard ratios (HRs) or relative risk (RR) with 95% confidence intervals (CIs) were used to calculate the correlation between EBER and prognosis and clinical features in DLBCL...
2018: PloS One
https://www.readbyqxmd.com/read/29920548/single-cell-transcriptome-analysis-of-mcf-7-reveals-consistently-and-inconsistently-expressed-gene-groups-each-associated-with-distinct-cellular-localization-and-functions
#7
Yih-Shien Chiang, Yu-Feng Huang, Mohit K Midha, Tzu-Han Chen, Hsin-Chieh Shiau, Kuo-Ping Chiu
Single cell transcriptome (SCT) analysis provides superior resolution to illustrate tumor cell heterogeneity for clinical implications. We characterized four SCTs of MCF-7 using 143 housekeeping genes (HKGs) as control, of which lactate dehydrogenase B (LDHB) expression is silenced. These SCT libraries mapped to 11,423, 11,486, 10,380, and 11,306 RefSeq genes (UCSC), respectively. High consistency in HKG expression levels across all four SCTs, along with transcriptional silencing of LDHB, was observed, suggesting a high sensitivity and reproducibility of the SCT analysis...
2018: PloS One
https://www.readbyqxmd.com/read/29917280/protective-effects-of-cinnamon-bark-extract-against-ischemia-reperfusion-injury-and-arrhythmias-in-rat
#8
Mehrnoosh Sedighi, Afshin Nazari, Mahdieh Faghihi, Mahmoud Rafieian-Kopaei, Arash Karimi, Maryam Moghimian, Seyyed Ali Mozaffarpur, Marzieh Rashidipour, Mehrdad Namdari, Mostafa Cheraghi, Bahram Rasoulian
Cinnamomum zeylanicum (cinnamon) is a plant with potent antioxidant activity and has been used in traditional medicine for improvement of heart function. The effects of cinnamon bark ethanolic extract were investigated against ischemia-induced arrhythmias and heart injury in an in vivo rat model of regional heart ischemia. The extract was also standardized, and its antioxidant activity was evaluated. Adult male Sprague-Dawley rats were subjected to 30 min of ischemia by occlusion of the left anterior descending coronary artery followed by 5 days of reperfusion...
June 19, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29917204/sestrin2-aggravates-oxidative-stress-of-neurons-by-decreasing-the-expression-of-nrf2
#9
L-L Zhang, Z-J Zhang
OBJECTIVE: Oxidative injury is an essential part of the pathological changes of cerebral ischemia-reperfusion. Sestrin2 (Sesn2), a conserved antioxidant protein, is activated under stress to protect cells against oxidative stress. This study mainly explored the function and mechanism of Sesn2 during cerebral ischemia-reperfusion injury in rats. MATERIALS AND METHODS: Oxygen-glucose deprivation/reoxygenation (OGD/R) model of primary neurons was established. MTS and LDH (lactate dehydrogenase) kit were used to detect cell viability and cell damage by colorimetric method...
June 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29916857/serum-lactate-level-accurately-predicts-mortality-in-critically-ill-patients-with-cirrhosis-with-acute-kidney-injury
#10
Dan-Qin Sun, Chen-Fei Zheng, Feng-Bin Lu, Sven Van Poucke, Xiao-Ming Chen, Yong-Ping Chen, Lai Zhang, Ming-Hua Zheng
BACKGROUND AND AIM: Serum lactate levels are routinely measured in critically ill patients with cirrhosis, and hyperlactatemia is a common finding, but its prognostic value remains controversial. Our aim was to examine whether serum lactate level could be used as a predictor of outcome in critically ill patients with cirrhosis (CICP) with acute kidney injury (AKI). PATIENTS AND METHODS: In this study, we included 480 consecutive patients with cirrhosis admitted to ICU, complicated with AKI, and were followed up for 365 days...
June 18, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29916308/the-mtor-pathway-regulates-pkm2-to-affect-glycolysis-in-esophageal-squamous-cell-carcinoma
#11
He Xiaoyu, Yin Yiru, Shi Shuisheng, Cheng Keyan, Yan Zixing, Cheng Shanglin, Wang Yuan, Cheng Dongming, Zhang Wangliang, Bai Xudong, Ma Jie
OBJECTIVES: Esophageal squamous cell carcinoma is a highly prevalent cancer withpoor survival rate and prognosis. Increasing evidence suggests an important role for metabolic regulation in treating esophageal squamous cell carcinoma, but the underlying mechanism remains unclear. The pyruvate kinase M2 isoform is a key enzyme in the energy production process, and the upregulation of pyruvate kinase M2 isoform also plays a crucial role in gene transcription and tumorigenesis. The mammalian target of rapamycin pathway regulates an array of cellular functions, including protein synthesis, metabolism, and cell proliferation...
January 1, 2018: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/29916286/chinese-medicine-ulcer-oil-promotes-the-healing-of-diabetic-foot-ulcers
#12
Hui Jia, Bohua Yang, Youshan Li, Chen Liang, Haibin Lu, Dongyang Lin, Ju Shang
Objective This study aimed to investigate the mechanism by which Chinese herbal medicine ulcer oil (UO) accelerates ulcer healing in a diabetic ulcer rat model. Methods Sprague Dawley rats were allocated at random into four groups: a control group, a positive control group (PC), a UO treatment group and an ethacridine lactate solution treatment group. Subcutaneous tissue was surgically removed from the rats on days 3, 7 and 14. The levels of protein phosphotyrosine phosphatase 1B (PTP1B), vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF) and advanced glycation end products (AGEs) were detected using western blot analysis...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29915579/cytokine-secretion-and-pyroptosis-of-thyroid-follicular-cells-mediated-by-enhanced-nlrp3-nlrp1-nlrc4-and-aim2-inflammasomes-are-associated-with-autoimmune-thyroiditis
#13
Qingling Guo, Ying Wu, Yuanyuan Hou, Yongping Liu, Tingting Liu, Hao Zhang, Chenling Fan, Haixia Guan, Yushu Li, Zhongyan Shan, Weiping Teng
Background: Inflammasomes, which mediate maturation of interleukin-1β (IL-β) and interleukin-18 (IL-18) and lead to pyroptosis, have been linked to various autoimmune disorders. This study investigated whether they are involved in the pathogenesis of autoimmune thyroiditis (AIT). Methods: We collected thyroid tissues from 50 patients with AIT and 50 sex- and age-matched controls. Serum levels of free T3, free T4, thyrotropin, thyroid peroxidase antibody (TPOAb), and thyroglobulin antibody (TgAb) were measured by electrochemiluminescent immunoassays...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29915503/exploring-factors-associated-with-bulk-tank-milk-urea-nitrogen-in-central-thailand
#14
Suppada Kananub, Wassana Jawjaroensri, John VanLeeuwen, Henrik Stryhn, Pipat Arunvipas
Aim: The study was to determine seasonal fluctuations and non-nutritional factors associated with bulk tank milk urea nitrogen(BTMUN). Materials and Methods: A total of 58,364 BTM testing records were collected from 2364 farms in Central Thailand during September 2014-August 2015. Using square root BTMUN as the outcome, other milk components, farm effect, and sampling time were analyzed by univariable repeated measures linear regression, and significant variables were included in multivariable repeated measures linear regression...
May 2018: Veterinary World
https://www.readbyqxmd.com/read/29915215/brain-fogginess-gas-and-bloating-a-link-between-sibo-probiotics-and-metabolic-acidosis
#15
Satish S C Rao, Abdul Rehman, Siegfried Yu, Nicole Martinez de Andino
BACKGROUND: D-lactic acidosis is characterized by brain fogginess (BF) and elevated D-lactate and occurs in short bowel syndrome. Whether it occurs in patients with an intact gut and unexplained gas and bloating is unknown. We aimed to determine if BF, gas and bloating is associated with D-lactic acidosis and small intestinal bacterial overgrowth (SIBO). METHODS: Patients with gas, bloating, BF, intact gut, and negative endoscopic and radiological tests, and those without BF were evaluated...
June 19, 2018: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/29915213/the-genotypic-and-phenotypic-spectrum-of-pars2-related-infantile-onset-encephalopathy
#16
Xiaomeng Yin, Beisha Tang, Xiao Mao, Jinxin Peng, Sheng Zeng, Yaqin Wang, Hong Jiang, Nan Li
Mitochondrial aminoacyl-tRNA synthetases (mt-aaRSs) are a family of enzymes that play critical roles in protein biosynthesis. Mutations in mt-aaRSs are associated with various diseases. As a member of the mt-aaRS family, PARS2 encoding prolyl-tRNA synthetase 2 was recently shown to be associated with Alpers syndrome and certain infantile-onset neurodegenerative disorders in four patients. Here, we present two patients in a pedigree with early developmental delay, epileptic spasms, delayed myelination combined with cerebellar white matter abnormalities, and progressive cortical atrophy...
June 18, 2018: Journal of Human Genetics
https://www.readbyqxmd.com/read/29914894/lncrna-fezf1-as1-promotes-tumor-proliferation-and-metastasis-in-colorectal-cancer-by-regulating-pkm2-signaling
#17
Zehua Bian, Jiwei Zhang, Min Li, Yuyang Feng, Xue Wang, Jia Zhang, Surui Yao, Guoying Jin, Jun Du, Weifeng Han, Yuan Yin, Shenglin Huang, Bojian Fei, Jian Zou, Zhaohui Huang
PURPOSE: Long non-coding RNAs (lncRNAs) play key roles in human cancers. Here, FEZF1-AS1, a highly overexpressed lncRNA in colorectal cancer (CRC), was identified by lncRNA microarrays. We aimed to explore the roles and possible molecular mechanisms of FEZF1-AS1 in CRC. EXPERIMENTAL DESIGN: LncRNA expression in CRC tissues was measured by lncRNA microarray and qRT-PCR. The functional roles of FEZF1-AS1 in CRC were demonstrated by a series of in vitro and in vivo experiments...
June 18, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29914776/cerebrospinal-fluid-lactate-concentration-and-bacterial-encephalitis-diagnosis
#18
M Maillet, T De Broucker, A Mailles, P Bouzat, J P Stahl
OBJECTIVES: A French national study on infectious encephalitis enrolled 253 patients in 2007. Fifty-two per cent of patients had a proven etiological diagnosis; 16% had bacterial encephalitis. We aimed to assess the predictive value of CSF lactate concentration to diagnose bacterial encephalitis. PATIENTS AND METHODS: Patients from the 2007 cohort whose CSF lactate concentration was available were included. Clinical and biological features associated with a bacterial etiology were assessed using univariate analysis and multivariate logistic regression...
June 15, 2018: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/29914687/fatty-and-hydroxycarboxylic-acid-receptors-the-missing-link-of-immune-response-and-metabolism-in-cattle
#19
REVIEW
P Alarcon, C Manosalva, M D Carretta, A I Hidalgo, C D Figueroa, A Taubert, C Hermosilla, M A Hidalgo, R A Burgos
Fatty and hydroxycarboxylic acids are one of the main intermediates of energy metabolism in ruminants and critical in the milk production of cattle. High production demands on a dairy farm can induce nutritional imbalances and metabolism disorders, which have been widely associated with the onset of sterile inflammatory processes and increased susceptibility to infections. The literature suggests that short-chain fatty acids (SCFA), long-chain fatty acids (LCFA) and hydroxycarboxylic acids are relevant modulators of the host innate inflammatory response...
July 2018: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/29914670/supplementation-of-oat-avena-sativa-l-extract-abates-alcohol-induced-acute-liver-injury-in-a-mouse-model
#20
Salma Mukhtar Mir, Bidya Dhar Sahu, Meghana Koneru, Madhusudana Kuncha, Mahesh Kumar Jerald, Halley Gora Ravuri, Sanjit Kanjilal, Ramakrishna Sistla
Dietary supplementation of oats has been associated with reduced risk of cardiovascular disease, diabetes, and gastrointestinal disorders. The role of oat extract as prophylactic in treating acute liver injury is not thoroughly established. We, therefore, hypothesized that oat extract would exert protective effect against alcohol-induced acute liver injury in a mouse model. To test this hypothesis, male C57BL/6 mice were pretreated with phenolic-enriched ethyl acetate (EA) fraction of oats (prepared by fractionating aqueous ethanolic extract with solvents of increasing polarity) at dosages of 125 and 250 mg kg-1 d-1 for 12 consecutive days...
June 2018: Nutrition Research
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