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https://www.readbyqxmd.com/read/28520873/association-between-neurocognitive-decline-and-visual-field-variability-in-glaucoma
#1
Alberto Diniz-Filho, Lisa Delano-Wood, Fábio B Daga, Sebastião Cronemberger, Felipe A Medeiros
Importance: Visual field variability may impair detection of glaucoma progression over time. Despite the possible overlap between neurocognitive disorders and glaucoma in older individuals, no study has investigated the association between cognitive changes and visual field variability. Objective: To evaluate the association between global neurocognitive impairment and visual field variability in patients diagnosed as having glaucoma or glaucoma suspects. Design, Setting, and Participants: This prospective observational cohort study was conducted at the Visual Performance Laboratory, University of California, San Diego...
May 18, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28515350/fam3a-enhances-adipogenesis-of-3t3-l1-preadipocytes-via-activation-of-atp-p2-receptor-akt-signaling-pathway
#2
Yujing Chi, Jing Li, Na Li, Zhenzhen Chen, Liping Ma, Weikang Peng, Xiuying Pan, Mei Li, Weidong Yu, Xiangjun He, Bin Geng, Qinghua Cui, Yulan Liu, Jichun Yang
FAM3A plays important roles in regulating hepatic glucose/lipid metabolism and the proliferation of VSMCs. This study determined the role and mechanism of FAM3A in the adipogenesis of 3T3-L1 preadipocytes. During the adipogenesis of 3T3-L1 preadipocytes, FAM3A expression was significantly increased. FAM3A overexpression enhanced 3T3-L1 preadipocyte adipogenesis with increased phosphorylated Akt (pAkt) level, whereas FAM3A silencing inhibited 3T3-L1 preadipocyte adipogenesis with reduced pAkt level. Moreover, FAM3A silencing reduced the expression and secretion of adipokines in 3T3-L1 cells...
May 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28464448/gene-expression-changes-of-thermo-sensitive-transient-receptor-potential-channels-in-obese-mice
#3
Wuping Sun, Chen Lib, Yonghong Zhang, Changyu Jiang, Mingzhu Zhai, Qian Zhou, Lizu Xiao, Qiwen Deng
Adipose tissues play key roles in energy homeostasis. Brown adipocytes and beige adipocytes in white adipose tissue (WAT) sharethe similar characters of thermogenesis, both of them could be potential targets for obesity management. Several thermo-sensitive transient receptor potential channels (thermoTRPs) are shown to be involved in adipocyte biology. However, the expression pattern of thermoTRPs in adipose tissues from obese mice is still unknown. The mRNA expression of thermoTRPs in subcutaneous WAT (sWAT) and interscapular brown adipose tissue (iBAT) from lean and obese mice were measured using Reverse Transcriptase-quantitative PCRs (RT-qPCR)...
May 2, 2017: Cell Biology International
https://www.readbyqxmd.com/read/28454843/monitoring-microwave-ablation-of-ex%C3%A2-vivo-bovine-liver-using-ultrasonic-attenuation-imaging
#4
Kayvan Samimi, James K White, Christopher L Brace, Tomy Varghese
Thermal ablation of soft tissue changes the tissue microstructure and, consequently, induces changes in its acoustic properties. Although B-mode ultrasound provides high-resolution and high-frame-rate images of ablative therapeutic procedures, it is not particularly effective at delineating boundaries of ablated regions because of poor contrast in echogenicity between ablated and surrounding normal tissue. Quantitative ultrasound techniques can provide quantitative estimates of acoustic properties, such as backscatter and attenuation coefficients, and differentiate ablated and unablated regions more effectively, with the potential for monitoring minimally invasive thermal therapies...
July 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28417101/role-of-active-listening-and-listening-effort-on-contralateral-suppression-of-transient-evoked-otoacousic-emissions
#5
Mohan Kumar Kalaiah, Nikhitha B Theruvan, Kaushlendra Kumar, Jayashree S Bhat
BACKGROUND AND OBJECTIVES: The present study aimed to investigate the effect of active listening and listening effort on the contralateral suppression of transient evoked otoacoustic emissions (CSTEOAEs). SUBJECTS AND METHODS: Twenty eight young adults participated in the study. Transient evoked otoacoustic emissions (TEOAEs) were recorded using 'linear' clicks at 60 dB peSPL, in three contralateral noise conditions. In condition 1, TEOAEs were obtained in the presence of white noise in the contralateral ear...
April 2017: Journal of Audiology & Otology
https://www.readbyqxmd.com/read/28388545/the-diagnostic-value-of-white-blood-cell-neutrophil-neutrophil-to-lymphocyte-ratio-and-lymphocyte-to-monocyte-ratio-in-patients-with-primary-angle-closure-glaucoma
#6
Shengjie Li, Wenjun Cao, Jianping Han, Binghua Tang, Xinghuai Sun
OBJECTIVE: Inflammatory mechanisms may have a role in the pathogenesis of primary angle closure glaucoma (PACG). The objective of this study was to investigate the diagnostic value of white blood cell (WBC), neutrophil, neutrophil to lymphocyte ratio (NLR), and lymphocyte to monocyte ratio (LMR) in patients with PACG and its association with glaucoma severity. METHOD: The study was retrospectively assessed in 771 consecutive PACG patients and 770 control subjects, laboratory parameters and clinical parameters were obtained from a medical data platform...
March 25, 2017: Oncotarget
https://www.readbyqxmd.com/read/28387741/effects-of-low-molecular-weight-fucoidan-and-high-stability-fucoxanthin-on-glucose-homeostasis-lipid-metabolism-and-liver-function-in-a-mouse-model-of-type-ii-diabetes
#7
Hong-Ting Victor Lin, Yu-Chi Tsou, Yu-Ting Chen, Wen-Jung Lu, Pai-An Hwang
The combined effects of low-molecular-weight fucoidan (LMF) and fucoxanthin (Fx) in terms of antihyperglycemic, antihyperlipidemic, and hepatoprotective activities were investigated in a mouse model of type II diabetes. The intake of LMF, Fx, and LMF + Fx lowered the blood sugar and fasting blood sugar levels, and increased serum adiponectin levels. The significant decrease in urinary sugar was only observed in LMF + Fx supplementation. LMF and Fx had ameliorating effects on the hepatic tissue of db/db mice by increasing hepatic glycogen and antioxidative enzymes, and LMF was more effective than Fx at improving hepatic glucose metabolism...
April 7, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28333120/an-analytical-model-for-bds-b1-spreading-code-self-interference-evaluation-considering-nh-code-effects
#8
Xin Zhang, Xingqun Zhan, Shaojun Feng, Washington Ochieng
The short spreading code used by the BeiDou Navigation Satellite System (BDS) B1-I or GPS Coarse/Acquistiion (C/A) can cause aggregately undesirable cross-correlation between signals within each single constellation. This GPS-to-GPS or BDS-to-BDS correlation is referred to as self-interference. A GPS C/A code self-interference model is extended to propose a self-interference model for BDS B1, taking into account the unique feature of the B1-I signal transmitted by BDS medium Earth orbit (MEO) and inclined geosynchronous orbit (IGSO) satellites-an extra Neumann-Hoffmann (NH) code...
March 23, 2017: Sensors
https://www.readbyqxmd.com/read/28325351/flexible-fiber-optic-high-speed-imaging-of-vocal-fold-vibration-a-preliminary-report
#9
Peak Woo, Peter Baxter
OBJECTIVE: High-speed video (HSV) imaging of vocal fold vibration has been possible only through the rigid endoscope. This study reports that a fiberscope-based high-speed imaging system may allow HSV imaging of naturalistic voicing. MATERIALS AND METHODS: Twenty-two subjects were recorded using a commercially available black and white high-speed camera (Photron Motion Tools, 256 × 120 pixel, 2000 frames per second, 8 second acquisition time). The camera gain is set to +6 db...
March 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/28286464/characterization-of-impulse-radio-intrabody-communication-system-for-wireless-body-area-networks
#10
Zibo Cai, MirHojjat Seyedi, Weiwei Zhang, Francois Rivet, Daniel T H Lai
Intrabody communication (IBC) is a promising data communication technique for body area networks. This short-distance communication approach uses human body tissue as the medium of signal propagation. IBC is defined as one of the physical layers for the new IEEE 802.15.6 or wireless body area network (WBAN) standard, which can provide a suitable data rate for real-time physiological data communication while consuming lower power compared to that of radio-frequency protocols such as Bluetooth. In this paper, impulse radio (IR) IBC (IR-IBC) is examined using a field-programmable gate array (FPGA) implementation of an IBC system...
2017: Journal of Medical and Biological Engineering
https://www.readbyqxmd.com/read/28274940/aortic-depressor-nerve-stimulation-does-not-impede-dynamic-characteristics-of-the-carotid-sinus-baroreflex-in-normotensive-or-spontaneously-hypertensive-rats
#11
Toru Kawada, Michael J Turner, Shuji Shimizu, Masafumi Fukumitsu, Atsunori Kamiya, Masaru Sugimachi
Recent clinical trials in patients with drug-resistant hypertension indicate that electrical activation of the carotid sinus baroreflex (baroreflex activation therapy) can reduce arterial pressure (AP) for more than a year. To examine whether the electrical stimulation from one baroreflex system impedes normal short-term AP regulation via another unstimulated baroreflex system, we electrically stimulated the left aortic depressor nerve (ADN) while estimating the dynamic characteristics of the carotid sinus baroreflex in anesthetized normotensive Wistar-Kyoto (WKY, n=8) rats and spontaneously hypertensive rats (SHR, n=7)...
March 8, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28255516/effect-of-noise-on-time-frequency-analysis-of-vibrocardiographic-signals
#12
A Taebi, H A Mansy
Recordings of biological signals such as vibrocardiography often contain contaminating noise. Noise sources may include respiratory, gastrointestinal, and muscles movement, or environmental noise. Depending on individual physiology and sensor location, the vibrocardiographic (VCG) signals may be obscured by these noises in the time-frequency plane, which may interfere with automated characterization of VCG. In this study, polynomial chirplet transform (PCT) and smoothed pseudo Wigner-Ville distribution (SPWVD) were used to estimate the instantaneous frequency (IF) of two simulated VCG signals...
September 2016: Journal of Bioengineering & Biomedical Science
https://www.readbyqxmd.com/read/28241531/minimal-post-processing-320-gbps-true-random-bit-generation-using-physical-white-chaos
#13
Anbang Wang, Longsheng Wang, Pu Li, Yuncai Wang
Chaotic external-cavity semiconductor laser (ECL) is a promising entropy source for generation of high-speed physical random bits or digital keys. The rate and randomness is unfortunately limited by laser relaxation oscillation and external-cavity resonance, and is usually improved by complicated post processing. Here, we propose using a physical broadband white chaos generated by optical heterodyning of two ECLs as entropy source to construct high-speed random bit generation (RBG) with minimal post processing...
February 20, 2017: Optics Express
https://www.readbyqxmd.com/read/28166900/effects-of-auditory-and-tactile-warning-on-response-to-visual-hazards-under-a-noisy-environment
#14
Atsuo Murata, Takashi Kuroda, Waldemar Karwowski
A warning signal presented via a visual or an auditory cue might interfere with auditory or visual information inside and outside a vehicle. On the other hand, such interference would be certainly reduced if a tactile cue is used. Therefore, it is expected that tactile cues would be promising as warning signals, especially in a noisy environment. In order to determine the most suitable modality of cue (warning) to a visual hazard in noisy environments, auditory and tactile cues were examined in this study. The condition of stimulus onset asynchrony (SOA) was set to 0ms, 500ms, and 1000ms...
April 2017: Applied Ergonomics
https://www.readbyqxmd.com/read/28164936/the-effects-of-acoustic-white-noise-on-the-rat-central-auditory-system-during-the-fetal-and-critical-neonatal-periods-a-stereological-study
#15
Mohammad Saied Salehi, Mohammad Reza Namavar, Amin Tamadon, Raziyeh Bahmani, Mohammad Reza Jafarzadeh Shirazi, Homayoun Khazali, Leila Dargahi, Sareh Pandamooz, Farzad Mohammad-Rezazadeh, Fatemeh Sadat Rashidi
AIM: To evaluate the effects of long-term, moderate level noise exposure during crucial periods of rat infants on stereological parameters of medial geniculate body (MGB) and auditory cortex. MATERIALS AND METHODS: Twenty-four male offspring of 12 pregnant rats were divided into four groups: fetal-to-critical period group, which were exposed to noise from the last 10 days of fetal life till postnatal day (PND) 29; fetal period group that exposed to noise during the last 10 days of fetal life; critical period group, exposed to noise from PND 15 till PND 29, and control group...
January 2017: Noise & Health
https://www.readbyqxmd.com/read/28161157/effect-of-scoparia-dulcis-on-noise-stress-induced-adaptive-immunity-and-cytokine-response-in-immunized-wistar-rats
#16
Loganathan Sundareswaran, Sakthivel Srinivasan, Wankupar Wankhar, Rathinasamy Sheeladevi
BACKGROUND: Noise acts as a stressor and is reported to have impact on individual health depending on nature, type, intensity and perception. Modern medicine has no effective drugs or cure to prevent its consequences. Being an environmental stressor noise cannot be avoided; instead minimizing its exposure or consuming anti-stressor and adaptogens from plants can be considered. OBJECTIVES: The present study was carried out to evaluate the anti-stressor, adaptogen and immunostimulatory activity of Scoparia dulcis against noise-induced stress in Wistar rat models...
January 2017: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/28152124/structural-and-functional-recovery-following-limited-iatrogenic-macular-detachment-for-retinal-gene-therapy
#17
RANDOMIZED CONTROLLED TRIAL
Matthew P Simunovic, Kanmin Xue, Jasleen K Jolly, Robert E MacLaren
Importance: The early decline and recovery of retinal structure and function following iatrogenic macular detachment for retinal gene therapy is not well characterized in those with relatively preserved central visual function. Here, the recovery of retinal structure and function over the first month following iatrogenic retinal detachment for the delivery of adeno-associated viral vector encoding Rab Escort Protein 1 is described as a part of gene therapy for choroideremia. Objective: To study changes in both retinal structure and function during the first month following iatrogenic macular detachment surgery...
March 1, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28129657/physiological-characterization-of-a-novel-ppar-pan-agonist-2-4-5-6-methylenedioxybenzo-d-thiazol-2-yl-2-methylphenoxy-2-methylpropanoic-acid-mhy2013
#18
Hye Jin An, Bonggi Lee, Dae Hyun Kim, Eun Kyeong Lee, Ki Wung Chung, Min Hi Park, Hyoung Oh Jeong, Sung Min Kim, Kyoung Mi Moon, Ye Ra Kim, Seong Jin Kim, Hwi Young Yun, Pusoon Chun, Byung Pal Yu, Hyung Ryong Moon, Hae Young Chung
Recently, agonists targeting multiple peroxisome proliferator-activated receptors (PPARs) have been developed to improve metabolic disorders and minimize the side effects of selective PPAR agonists such as weight gain and dyslipidemia. We newly synthesized six 2-methyl-2-(o-tolyloxy)propanoic acid derivatives based on the structure of a well-known PPAR pan agonist, bezafibrate. Of six compounds, MHY2013 was screened as the strongest activator of three PPAR subtypes based on protein docking simulation and luciferase assays...
March 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28126063/eyeblink-conditioning-with-a-noise-burst-as-unconditioned-stimulus
#19
José L Marcos Malmierca, Azahara Marcos de Vega
BACKGROUND: The aim of this study was to determine if a white noise burst could be used as an effective unconditioned stimulus (US) to produce differential conditioning of eyeblink responses that were recorded as EMG activity of the orbicularis oculi. METHOD: Two fear-relevant stimuli served as conditioned stimuli (CS). An angry woman’s face (CS+) was consistently followed by a white noise burst (US) with 100 dB intensity and 100 milliseconds in duration.  A fearful face of the same woman (CS-) was not followed by the US...
February 2017: Psicothema
https://www.readbyqxmd.com/read/28108342/effects-of-dietary-lactobacillus-plantarum-in-different-treatments-on-growth-performance-and-immune-gene-expression-of-white-shrimp-litopenaeus-vannamei-under-normal-condition-and-stress-of-acute-low-salinity
#20
Xiaoting Zheng, Yafei Duan, Hongbiao Dong, Jiasong Zhang
A 45-day feeding trial followed by an acute stress test of low salinity was done to evaluate effects of Lactobacillus plantarum on growth performance and anti-stress capability of white shrimp (Litopenaeus vannamei). Shrimp were randomly allocated in 15 tanks (100 shrimp per tank) and divided into 5 treatments with 3 replicates. Triplicate tanks were fed with a control diet or diets containing different treatments of L. plantarum (fermentation supernatant (FS), live bacteria (LB), dead bacteria (DB) and cell-free extract (CE) of L...
March 2017: Fish & Shellfish Immunology
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