Read by QxMD icon Read

DB White

Dongrae Cho, Beomjun Min, Jongin Kim, Boreom Lee
In this study, we examined the phase locking value (PLV) for seizure prediction, particularly, in the gamma frequency band. We prepared simulation data and 65 clinical cases of seizure. In addition, various filtering algorithms including bandpass filtering, empirical mode decomposition, multivariate empirical mode decomposition and noise-assisted multivariate empirical mode decomposition (NA-MEMD) were used to decompose spectral components from the data. Moreover, in the case of clinical data, the PLVs were used to classify between interictal and preictal stages using a support vector machine...
October 19, 2016: IEEE Transactions on Neural Systems and Rehabilitation Engineering
George Bakris
Renal denervation started out as a very promising approach to treat resistant hypertension with a very strong conceptual and basic science frame work from Gerald DiBona's lab and extending into the early non shame clinical studies demonstrating proof of concept in SYMPLICITY HTN-1 and 2. SYMPLICITY-HTN 3 a properly done, sham control trial failed to show a benefit on further reduction of BP compared to the sham group. The conclusion the procedure doesn't work. How could this be-it was clearly effective in animal models but why not in man...
September 2016: Journal of Hypertension
M M Fathi, I Al-Homidan, M I Motawei, O K Abou-Emera, M F El-Zarei
The present study was conducted to evaluate the genetic diversity and relationships of 5 Saudi native chicken populations and a White Leghorn (L) strain as an exotic breed, using 25 microsatellite markers. According to morphological appearance and plumage color and pattern, they were classified into black (BL), black-barred (BR), dark brown (DB), light brown (LB), and gray (G) breeds. Twenty-five microsatellite markers were chosen based on the degree of polymorphism reported in the previous literature. The results revealed that all studied markers exhibited a varied percentage of polymorphism among native chicken populations...
September 24, 2016: Poultry Science
George Bakris
Renal denervation started out as a very promising approach to treat resistant hypertension with a very strong conceptual and basic science frame work from Gerald DiBona's lab and extending into the early non shame clinical studies demonstrating proof of concept in SYMPLICITY HTN-1 and 2. SYMPLICITY-HTN 3 a properly done, sham control trial failed to show a benefit on further reduction of BP compared to the sham group. The conclusion the procedure doesn't work. How could this be-it was clearly effective in animal models but why not in man...
September 2016: Journal of Hypertension
Rachel Sjouwerman, Johanna Niehaus, Manuel Kuhn, Tina B Lonsdorf
Reproducibility is fundamental to science and a recent matter of discussion. We report challenges for conceptual replications when employing different readout measures to target the same theoretical construct, particularly those requiring probed reactions. This was addressed in a fear conditioning paradigm, a prototype of emotional learning, in three experimental groups (Ntotal  = 57). We demonstrate that the inclusion of startle probes (95 dB burst of white noise) to elicit a startle reflex delays the acquisition of fear as reflected by skin conductance responses and intermittent fear ratings...
September 15, 2016: Psychophysiology
Stavros N Moysidis, Nicole Koulisis, Vivek R Patel, Amir H Kashani, Narsing A Rao, Mark S Humayun, Damien C Rodger
PURPOSE: To describe a case of small retinal vessel vasculopathy postvaccination. METHODS: We report the case of a 41-year-old white man who presented with a "second blind spot," describing a nasal scotoma in the right eye that started 4 days after vaccinations against Neisseria meningitidis and the yellow fever virus, and after a 2-month period of high stress and decreased sleep. Clinical examination, Humphrey visual field testing, and multimodal imaging with fundus photographs, autofluorescence, fluorescein angiography, and spectral domain optical coherence tomography and angiography were performed...
September 2, 2016: Retinal Cases & Brief Reports
Eric D Melonakos, John A White, Fernando R Fernandez
Hippocampal network oscillations are important for learning and memory. Theta rhythms are involved in attention, navigation, and memory encoding, whereas sharp wave-ripple complexes are involved in memory consolidation. Cholinergic neurons in the medial septum-diagonal band of Broca (MS-DB) influence both types of hippocampal oscillations, promoting theta rhythms and suppressing sharp wave-ripples. They also receive frequency-dependent hyperpolarizing feedback from hippocamposeptal connections, potentially affecting their role as neuromodulators in the septohippocampal circuit...
September 2, 2016: Hippocampus
Vincent Giordano, Christophe Fluhr, Benoît Dubois, Enrico Rubiola
We present the characterization of commercial tunnel diode low-level microwave power detectors at room and cryogenic temperatures. The sensitivity as well as the output voltage noise of the tunnel diodes is measured as functions of the applied microwave power. We highlight strong variations of the diode characteristics when the applied microwave power is higher than a few microwatts. For a diode operating at 4 K, the differential gain increases from 1000 V/W to about 4500 V/W when the power passes from -30 dBm to -20 dBm...
August 2016: Review of Scientific Instruments
Jennifer Koch, Jan Flemming, Thomas Zeffiro, Michael Rufer, Scott P Orr, Christoph Mueller-Pfeiffer
In the "loud-tone" procedure, a series of brief, loud, pure-tone stimuli are presented in a task-free situation. It is an established paradigm for measuring autonomic sensitization in posttraumatic stress disorder (PTSD). Successful use of this procedure during fMRI requires elicitation of brain responses that have sufficient signal-noise ratios when recorded in a supine, rather than sitting, position. We investigated the modulating effects of posture and stimulus spectral composition on peripheral psychophysiological responses to loud sounds...
2016: PloS One
Andrew Dimitrijevic, Jamal Alsamri, M Sasha John, David Purcell, Sahara George, Fan-Gang Zeng
OBJECTIVE: To record envelope following responses (EFRs) to monaural amplitude-modulated broadband noise carriers in which amplitude modulation (AM) depth was slowly changed over time and to compare these objective electrophysiological measures to subjective behavioral thresholds in young normal hearing and older subjects. DESIGN: HASH(0x4a80580) PARTICIPANTS: three groups of subjects included a young normal-hearing group (YNH 18 to 28 years; pure-tone average = 5 dB HL), a first older group ("O1"; 41 to 62 years; pure-tone average = 19 dB HL), and a second older group ("O2"; 67 to 82 years; pure-tone average = 35 dB HL)...
September 2016: Ear and Hearing
Adele M Goman, Frank R Lin
OBJECTIVES: To estimate the age- and severity-specific prevalence of hearing impairment in the United States. METHODS: We conducted cross-sectional analyses of 2001 through 2010 data from the National Health and Nutrition Examination Survey on 9648 individuals aged 12 years or older. Hearing loss was defined as mild (> 25 dB through 40 dB), moderate (> 40 dB through 60 dB), severe (> 60 dB through 80 dB), or profound (> 80 dB). RESULTS: An estimated 25...
October 2016: American Journal of Public Health
Sylwia Szrok, Ewa Stelmanska, Jacek Turyn, Aleksandra Bielicka-Gieldon, Tomasz Sledzinski, Julian Swierczynski
BACKGROUND: Cumulating evidence underlines the role of adipose tissue metallothionein (MT) in the development of obesity and type 2 diabetes. Fasting/refeeding was shown to affect MT gene expression in the rodent liver. The influence of nutritional status on MT gene expression in white adipose tissue (WAT) is inconclusive. The aim of this study was to verify if fasting and fasting/refeeding may influence expression of MT genes in WAT of rats. RESULTS: Fasting resulted in a significant increase in MT1 and MT2 gene expressions in retroperitoneal, epididymal, and inguinal WAT of rats, and this effect was reversed by refeeding...
2016: Genes & Nutrition
Xianyong Ma, Wei Fang, Zongyong Jiang, Li Wang, Xuefen Yang, Kaiguo Gao
BACKGROUND: The mechanism of db-cAMP regulating fat deposition and improving lean percentage is unclear and needs to be further studied. METHODS: Eighteen 100-day-old Duroc × Landrance × Large White barrows (49.75 ± 0.75 kg) were used for experiment 1, and 15 eighteen 135-day-old barrows (78.34 ± 1.22 kg) were used for experiment 2 to investigate the effects of dietary dibutyryl-cAMP (db-cAMP) on fat deposition in finishing pigs. Pigs were fed with a corn-soybean meal-based diet supplemented with 0 or 15 mg/kg db-cAMP, and both experiments lasted 35 days, respectively...
2016: Genes & Nutrition
Manoranjan Sharma, Jogeswar Mohapatra, Umar Malik, Jignesh Nagar, Abhijit Chatterjee, Balaraman Ramachandran, Mukul R Jain
BACKGROUND: Infectious diseases are more frequent in diabetic patients, leading to increased morbidity and mortality. Endotoxemia affects glucose metabolism and lipolytic capacity. The aims of the present study were to determine whether endotoxemia exacerbates metabolic features (adipose inflammation, adipogenesis, and insulin resistance [IR]) in an animal model of diabetes (i.e. db/db mice) after acute infection and the effects of pioglitazone. METHODS: Female db/db mice treated with pioglitazone (3 and 30 mg/kg, p...
July 22, 2016: Journal of Diabetes
Chuang Li, Jun Yang, Zhangjun Yu, Yonggui Yuan, Bing Wu, Feng Peng, Jianzhong Zhang, Ai Zhou, Yu Zhang, Zhihai Liu, Libo Yuan
This paper presents a method to improve the dynamic range of white light interferometer (WLI) based polarization mode coupling (PMC) measurement system beyond 100 dB. The limitation of interference beat noise is overcame by analyzing in detail the inherent noises that have impacts on the detection sensitivity. An improved PMC measurement system and method are proposed for testing ultra-high polarization extinction ratio (PER) of polarization-related devices. The method can improve dynamic range dramatically through eliminating interference beat noise and enhancing the tested interference intensity simultaneously, which are verified theoretically and experimentally...
July 25, 2016: Optics Express
Hu Xu, Jia-Lin Fu, Yi-Fei Miao, Chun-Jiong Wang, Qi-Fei Han, Sha Li, Shi-Zheng Huang, Sheng-Nan Du, Yu-Xiang Qiu, Ji-Chun Yang, Jan-Åke Gustafsson, Richard M Breyer, Feng Zheng, Nan-Ping Wang, Xiao-Yan Zhang, You-Fei Guan
Among the four prostaglandin E2 receptors, EP3 receptor is the one most abundantly expressed in white adipose tissue (WAT). The mouse EP3 gene gives rise to three isoforms, namely EP3α, EP3β, and EP3γ, which differ only at their C-terminal tails. To date, functions of EP3 receptor and its isoforms in WAT remain incompletely characterized. In this study, we found that the expression of all EP3 isoforms were downregulated in WAT of both db/db and high-fat diet-induced obese mice. Genetic ablation of three EP3 receptor isoforms (EP3(-/-) mice) or EP3α and EP3γ isoforms with EP3β intact (EP3β mice) led to an obese phenotype with increased food intake, decreased motor activity, reduced insulin sensitivity, and elevated serum TG...
July 19, 2016: Journal of Molecular Cell Biology
Nabeel A Riza, Juan Pablo La Torre, M Junaid Amin
Proposed and experimentally demonstrated is the CAOS-CMOS camera design that combines the coded access optical sensor (CAOS) imager platform with the CMOS multi-pixel optical sensor. The unique CAOS-CMOS camera engages the classic CMOS sensor light staring mode with the time-frequency-space agile pixel CAOS imager mode within one programmable optical unit to realize a high dynamic range imager for extreme light contrast conditions. The experimentally demonstrated CAOS-CMOS camera is built using a digital micromirror device, a silicon point-photo-detector with a variable gain amplifier, and a silicon CMOS sensor with a maximum rated 51...
June 13, 2016: Optics Express
Guang-Yang Liu, Jin Liu, You-Liang Wang, Yang Liu, Yong Shao, Yan Han, Ya-Ru Qin, Feng-Jun Xiao, Peng-Fei Li, Lan-Jun Zhao, En-Yan Gu, Si-Yu Chen, Li-Hua Gao, Chu-Tse Wu, Xian-Wen Hu, Hai-Feng Duan
UNLABELLED: : Adipose-derived mesenchymal stem cells (AD-MSCs) have been shown to ameliorate hyperglycemia in diabetic animals and individuals. However, little is known about whether AD-MSCs affect lipid metabolism. Here we have demonstrated for the first time that AD-MSC infusion can significantly suppress the increase in body weight and remarkably improve dyslipidemia in db/db obese mice and diet-induced obesity mice. Induction of white fat tissue "browning" and activation of adenosine monophosphate-activated protein kinase and its downstream hormone-sensitive lipase in adipose tissue contribute to the antiobesity and lipid-lowering effects...
September 2016: Stem Cells Translational Medicine
Jonathan M Vaisberg, Ewan A Macpherson, Susan D Scollie
OBJECTIVE: Direct real-ear measurement to the 4-6 kHz range can be measured with suitable accuracy and repeatability. This study evaluates extended bandwidth measurement accuracy and repeatability using narrowband and wideband signal analysis. DESIGN: White noise was measured in female ear canals at four insertion depths using one-third and one-twenty-fourth octave band averaging. STUDY SAMPLE: Fourteen female adults with reported normal hearing and middle-ear function participated in the study...
October 2016: International Journal of Audiology
Riki Taitelbaum-Swead, Leah Fostick
OBJECTIVE: Everyday life includes fluctuating noise levels, resulting in continuously changing speech intelligibility. The study aims were: (1) to quantify the amount of decrease in age-related speech perception, as a result of increasing noise level, and (2) to test the effect of age on context usage at the word level (smaller amount of contextual cues). PATIENTS AND METHODS: A total of 24 young adults (age 20-30 years) and 20 older adults (age 60-75 years) were tested...
2016: Folia Phoniatrica et Logopaedica
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"