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https://www.readbyqxmd.com/read/29341316/deferoxamine-promotes-mesenchymal-stem-cell-homing-in-noise-induced-injured-cochlea-through-pi3k-akt-pathway
#1
A A Peyvandi, H-A Abbaszadeh, N Ahmady Roozbahany, A Pourbakht, S Khoshsirat, H Haddadzade Niri, H Peyvandi, S Niknazar
OBJECTIVE: Over 5% of the world's population suffers from disabling hearing loss. Stem cell homing in target tissue is an important aspect of cell-based therapy, which its augmentation increases cell therapy efficiency. Deferoxamine (DFO) can induce the Akt activation, and phosphorylation status of AKT (p-AKT) upregulates CXC chemokine receptor-4 (CXCR4) expression. We examined whether DFO can enhance mesenchymal stem cells (MSCs) homing in noise-induced damaged cochlea by PI3K/AKT dependent mechanism...
January 17, 2018: Cell Proliferation
https://www.readbyqxmd.com/read/29335654/microwave-squid-multiplexer-demonstration-for-cosmic-microwave-background-imagers
#2
B Dober, D T Becker, D A Bennett, S A Bryan, S M Duff, J D Gard, J P Hays-Wehle, G C Hilton, J Hubmayr, J A B Mates, C D Reintsema, L R Vale, J N Ullom
Key performance characteristics are demonstrated for the microwave SQUID multiplexer (µmux) coupled to transition edge sensor (TES) bolometers that have been optimized for cosmic microwave background (CMB) observations. In a 64-channel demonstration, we show that the µmux produces a white, input referred current noise level of [Formula: see text] at -77 dB microwave probe tone power, which is well below expected fundamental detector and photon noise sources for a ground-based CMB-optimized bolometer. Operated with negligible photon loading, we measure [Formula: see text] in the TES-coupled channels biased at 65% of the sensor normal resistance...
December 2017: Applied Physics Letters
https://www.readbyqxmd.com/read/29317248/cognitive-decline-and-increased-hippocampal-p-tau-expression-in-mice-with-hearing-loss
#3
So Young Park, Min Jung Kim, Hong Lim Kim, Dong Kee Kim, Sang Won Yeo, Shi Nae Park
Hearing and cognition are commonly involved in both normal and pathological aging. Current clinical interest lies in whether peripheral hearing loss promotes cognitive decline. In our previous publication, the authors have shown a causal relationship between hearing and cognitive impairments in C57BL/6 mice. Here we extended the follow-up to 12 months to determine the long-term effects of hearing loss on cognition and to observe hippocampal p-tau and lipofuscin. One month old male mice were randomly allocated into two groups, the control (n = 12) and noise-induced hearing loss (NIHL) (n = 12)...
January 6, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29310876/effect-of-ceramic-material-and-resin-cement-systems-on-the-color-stability-of-laminate-veneers-after-accelerated-aging
#4
Seong-Min Lee, Yu-Sung Choi
STATEMENT OF PROBLEM: Laminate veneers are susceptible to color change during clinical service. Studies that compare the effects of different ceramic and resin cement systems on color stability are lacking. PURPOSE: The purpose of this in vitro study was to evaluate the color stability of laminate veneers after accelerated aging using different ceramic and resin cement systems. MATERIAL AND METHODS: Ceramic specimens (N=168; shade A1; thickness, 0...
January 5, 2018: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/29304059/space-use-by-4-strains-of-laying-hens-to-perch-wing-flap-dust-bathe-stand-and-lie-down
#5
Elizabeth R Riddle, Ahmed B A Ali, Dana L M Campbell, Janice M Siegford
The laying hen industry is implementing aviary systems intended to improve welfare by providing hens with more space and resources to perform species-specific behaviors. To date, limited research has examined spatial requirements of various strains of laying hens for performing key behaviors and none has been conducted within an alternative housing system. This study investigated the amount of space used by 4 strains of laying hens (Hy-Line Brown [HB], Bovans Brown [BB], DeKalb White [DW], and Hy-Line W36) to perform 5 different behaviors in the litter area of a commercial-style aviary...
2018: PloS One
https://www.readbyqxmd.com/read/29242563/ck2-modulates-adipocyte-insulin-signaling-and-is-up-regulated-in-human-obesity
#6
Christian Borgo, Gabriella Milan, Francesca Favaretto, Fabio Stasi, Roberto Fabris, Valentina Salizzato, Luca Cesaro, Anna Belligoli, Marta Sanna, Mirto Foletto, Luca Prevedello, Vincenzo Vindigni, Romeo Bardini, Arianna Donella-Deana, Roberto Vettor
Insulin plays a major role in glucose metabolism and insulin-signaling defects are present in obesity and diabetes. CK2 is a pleiotropic protein kinase implicated in fundamental cellular pathways and abnormally elevated in tumors. Here we report that in human and murine adipocytes CK2-inhibition decreases the insulin-induced glucose-uptake by counteracting Akt-signaling and GLUT4-translocation to the plasma membrane. In mice CK2 acts on insulin-signaling in adipose tissue, liver and skeletal muscle and its acute inhibition impairs glucose tolerance...
December 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29228900/effects-of-chronic-noise-on-the-corticotropin-releasing-factor-system-in-the-rat-hippocampus-relevance-to-alzheimer-s-disease-like-tau-hyperphosphorylation
#7
Zhihui Gai, Donghong Su, Yawen Wang, Wenlong Li, Bo Cui, Kang Li, Xiaojun She, Rui Wang
BACKGROUND: Chronic noise exposure has been associated with tau hyperphosphorylation and Alzheimer's disease (AD)-like pathological changes, but the underlying mechanism is unknown. In this study, we explored the effects of long-term noise exposure on the corticotropin-releasing factor (CRF) system in the hippocampus and its role in noise-induced tau phosphorylation. METHODS: Sixty-four rats were randomly divided into the noise-exposed group and the control group, and rats in the exposure group were exposed to 95 dB SPL white noise for 30 consecutive days...
December 11, 2017: Environmental Health and Preventive Medicine
https://www.readbyqxmd.com/read/29216226/startling-similarity-effects-of-facial-self-resemblance-and-familiarity-on-the-processing-of-emotional-faces
#8
Johannes B Finke, Mauro F Larra, Martina U Merz, Hartmut Schächinger
Facial self-resemblance has been associated with positive emotional evaluations, but this effect may be biased by self-face familiarity. Here we report two experiments utilizing startle modulation to investigate how the processing of facial expressions of emotion is affected by subtle resemblance to the self as well as to familiar faces. Participants of the first experiment (I) (N = 39) were presented with morphed faces showing happy, neutral, and fearful expressions which were manipulated to resemble either their own or unknown faces...
2017: PloS One
https://www.readbyqxmd.com/read/29212354/image-quality-assessment-of-silent-t2-propeller-sequence-for-brain-imaging-in-infants
#9
Hyun Gi Kim, Jin Wook Choi, Soo Han Yoon, Sieun Lee
OBJECTIVE: Infants are vulnerable to high acoustic noise. Acoustic noise generated by MR scanning can be reduced by a silent sequence. The purpose of this study is to compare the image quality of the conventional and silent T2 PROPELLER sequences for brain imaging in infants. METHODS: A total of 36 scans were acquired from 24 infants using a 3.0 T MR scanner. Each patient underwent both conventional and silent T2 PROPELLER sequences. Acoustic noise level was measured...
December 7, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29203067/personalized-prediction-of-glaucoma-progression-under-different-target-intraocular-pressure-levels-using-filtered-forecasting-methods
#10
Pooyan Kazemian, Mariel S Lavieri, Mark P Van Oyen, Chris Andrews, Joshua D Stein
PURPOSE: To generate personalized forecasts of how patients with open-angle glaucoma (OAG) experience disease progression at different intraocular pressure (IOP) levels to aid clinicians with setting personalized target IOPs. DESIGN: Secondary analyses using longitudinal data from 2 randomized controlled trials. PARTICIPANTS: Participants with moderate or advanced OAG from the Collaborative Initial Glaucoma Treatment Study (CIGTS) or the Advanced Glaucoma Intervention Study (AGIS)...
December 1, 2017: Ophthalmology
https://www.readbyqxmd.com/read/29170318/21%C3%A2-daily-dynamic-discharge-a-whole-system-solution-to-ed-crowding
#11
Jacques Kerr, Helen Maitland, Claire Bell, Julie White, Alan Hunter
INTRODUCTION: ED crowding is associated with increased mortality, poor staff and patient experience, an increased inpatient length of stay and poor compliance with the four-hour emergency access standard.1 Where crowding is caused by exit block, the focus needs to be on whole system patient management, reducing the temporal mismatch between admissions and discharges since at times of peak demand hospitals may become gridlocked until patients are discharged.In an attempt to tackle exit block, the Scottish Government Unscheduled Care Team have implemented the Daily Dynamic Discharge (DDD) approach, which aims to increase the number of inpatient discharges by 12 pm, thus enabling more timeous flow through the ED...
December 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29159885/two-stage-ionoacoustic-range-verification-leveraging-monte-carlo-and-acoustic-simulations-to-stably-account-for-tissue-inhomogeneity-and-accelerator-specific-time-structure-a-simulation-study
#12
Sarah K Patch, Daniel E M Hoff, Tyler B Webb, Lee G Sobotka, Tianyu Zhao
PURPOSE: Range errors constrain treatment planning by limiting choice of ion beam angles and requiring large margins. Ionoacoustic range verification requires recovering the location of an acoustic source from low frequency signals. A priori information is applied to stably overcome resolution limits of inverse acoustic source imaging in this simulation study. In particular, the accuracy and robustness of ionoacoustic range verification for lateral and oblique delivery of high-energy protons to the prostate is examined...
November 20, 2017: Medical Physics
https://www.readbyqxmd.com/read/29151468/-numerical-and-visual-evaluation-of-compressed-sensing-mri-using-3d-cartesian-sampling
#13
Hiroyuki Shinohara, Takeyuki Hashimoto, Nobuyuki Takeyama, Eriko Tanaka, Takaki Hayashi, Touji Hashimoto
We performed numerical and visual evaluation of compressed sensing MRI (CS-MRI) using 3D Cartesian sampling by numerical simulation. Three brain anatomical ROIs (white matter, gray matter, cerebrospinal fluid) of a T1-weighted image (T1WI), a T2-weighted image (T2WI) and a proton density-weighted image (PDWI) were used for numerical evaluation. Sampling ratio of the Cartesian grid was 30%. Reconstruction was performed by the projection onto convex sets (POCS) method with soft thresholding, subject to data fidelity constraints...
2017: Japanese Journal of Medical Physics
https://www.readbyqxmd.com/read/29141998/vanillic-acid-attenuates-obesity-via-activation-of-the-ampk-pathway-and-thermogenic-factors-in-vivo-and-in-vitro
#14
Yunu Jung, Jinbong Park, Hye-Lin Kim, Jung-Eun Sim, Dong-Hyun Youn, JongWook Kang, Seona Lim, Mi-Young Jeong, Woong Mo Yang, Seok-Geun Lee, Kwang Seok Ahn, Jae-Young Um
Energy expenditure is a target gaining recent interest for obesity treatment. The antiobesity effect of vanillic acid (VA), a well-known flavoring agent, was investigated in vivo and in vitro High-fat diet (HFD)-induced obese mice and genetically obese db/db mice showed significantly decreased body weights after VA administration. Two major adipogenic markers, peroxisome proliferator activated receptor γ (PPARγ) and CCAAT/enhancer-binding protein α (C/EBPα), were reduced while the key factor of energy metabolism, AMPKα, was increased in the white adipose tissue and liver tissue of VA-treated mice...
November 15, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29118022/tonic-aortic-depressor-nerve-stimulation-does-not-impede-baroreflex-dynamic-characteristics-concomitantly-mediated-by-the-stimulated-nerve
#15
Toru Kawada, Michael J Turner, Shuji Shimizu, Atsunori Kamiya, Toshiaki Shishido, Masaru Sugimachi
Although electrical activation of the carotid sinus baroreflex (baroreflex activation therapy) is being explored as a device therapy for resistant hypertension, possible effects on baroreflex dynamic characteristics of interaction between electrical stimulation and pressure inputs are not fully elucidated. To examine whether the electrical stimulation of the baroreceptor afferent nerve impedes normal short-term arterial pressure (AP) regulation mediated by the stimulated nerve, we electrically stimulated the right aortic depressor nerve (ADN) while estimating the baroreflex dynamic characteristics by imposing pressure inputs to the isolated baroreceptor region of the right ADN in nine anesthetized rats...
November 8, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29117949/trends-in-hearing-loss-among-adolescents
#16
Tyson S Barrett, Karl R White
OBJECTIVES: Our aim with this article is to evaluate whether the prevalence of hearing loss is increasing among adolescents living in the United States. METHODS: All available data about hearing loss among adolescents from the large, federally funded National Health and Nutrition Examination Survey (NHANES) were analyzed. By using the 4 data releases between 1994 and 2010 (a total of 6891 adolescents), the prevalence of adolescent hearing loss >15 and ≥25 dB at low frequencies (0...
November 8, 2017: Pediatrics
https://www.readbyqxmd.com/read/29100627/locus-coeruleus-activity-mediates-hyperresponsiveness-in-posttraumatic-stress-disorder
#17
Christoph Naegeli, Thomas Zeffiro, Marco Piccirelli, Assia Jaillard, Anina Weilenmann, Katayun Hassanpour, Matthis Schick, Michael Rufer, Scott P Orr, Christoph Mueller-Pfeiffer
BACKGROUND: Patients with posttraumatic stress disorder (PTSD) are hyperresponsive to unexpected or potentially threatening environmental stimuli. Research in lower animals and humans suggests that sensitization of the locus coeruleus-norepinephrine system may underlie behavioral and autonomic hyperresponsiveness in PTSD. However, direct evidence linking locus coeruleus system hyperactivity to PTSD hyperresponsiveness is sparse. METHODS: Psychophysiological recording and functional magnetic resonance imaging were used during passive listening to brief, 95-dB sound pressure level, white noise bursts presented intermittently to determine whether behavioral and autonomic hyperresponsiveness to sudden sounds in PTSD is associated with locus coeruleus hyperresponsiveness...
September 7, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/29091688/suppression-of-interference-noise-caused-by-fresnel-reflection-in-all-fiber-white-light-interferometer
#18
Yonggui Yuan, Yongqing Cheng, Jun Yang, Haoliang Zhang, Dongchuan Lu, Yan Lv, Feng Peng, Hanyang Li, Xiaojun Zhang, Fuqiang Jiang, Libo Yuan
We propose methods to suppress the interference noise (IN) of an all-fiber white-light interferometer (WLI), which is caused by the residual Fresnel reflective beam. The methods are proposed to ensure a wide dynamic range and enhance the accuracy of measurement. IN can cause misjudgment of the realistic optical characteristic parameters, such as the fault diagnosis and polarization coupling of the optical devices under test. In addition, IN can reduce the dynamic range of the WLI. The optical path mismatch (OPM) method and the intensity suppression (IS) method by changing the positions and intensity of the IN are presented...
November 1, 2017: Applied Optics
https://www.readbyqxmd.com/read/29060511/performance-comparison-of-wavelet-based-denoising-methods-on-discontinuous-adventitious-lung-sounds
#19
Sezer Ulukaya, Gorkem Serbes, Yasemin P Kahya
Crackles and their time-domain characteristics provide important clues about different lung diseases. In this paper, we aim to de-noise synthetically produced crackles under various noise levels while preserving their information bearing parts which significantly affect crackle parameters. Classical wavelet based de-noising algorithms are deteriorated by sharp-sudden noise changes and produce Gibbs like fluctuations. On the other hand, total variation based algorithms, which are capable of alleviating the drawbacks of the classical wavelet based algorithms, are failed when dealing with piecewise-smooth signals like crackles and generate unwanted flat regions on the de-noised signals...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29048027/measurement-error-analysis-for-polarization-extinction-ratio-of-multifunctional-integrated-optic-chips
#20
Haoliang Zhang, Jun Yang, Chuang Li, Zhangjun Yu, Zhe Yang, Yonggui Yuan, Feng Peng, Hanyang Li, Changbo Hou, Jianzhong Zhang, Libo Yuan, Jianming Xu, Chao Zhang, Quanfu Yu
Measurement error for the polarization extinction ratio (PER) of a multifunctional integrated optic chip (MFIOC) utilizing white light interferometry was analyzed. Three influence factors derived from the all-fiber device (or optical circuit) under test were demonstrated to be the main error sources, including: 1) the axis-alignment angle (AA) of the connection point between the extended polarization-maintaining fiber (PMF) and the chip PMF pigtail; 2) the oriented angle (OA) of the linear polarizer; and 3) the birefringence dispersion of PMF and the MFIOC chip...
August 20, 2017: Applied Optics
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