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https://www.readbyqxmd.com/read/27897448/diagnostic-ability-of-automated-pupillography-in-glaucoma
#1
Harsha L Rao, Sujatha V Kadambi, Pooja Mehta, Srilakshmi Dasari, Narendra K Puttaiah, Zia S Pradhan, Dhanraj A S Rao, Rohit Shetty
PURPOSE: To evaluate the diagnostic ability of automated pupillography measurements in glaucoma and study the effect of inter-eye asymmetry in glaucomatous damage on the diagnostic ability. METHODS: In an observational, cross-sectional study, 47 glaucoma patients and 42 control subjects underwent automated pupillography using a commercially available device. Diagnostic abilities of the pupillary response measurements were evaluated using area under receiver operating characteristic (ROC) curves (AUC) and sensitivities at fixed specificities...
November 29, 2016: Current Eye Research
https://www.readbyqxmd.com/read/27897127/effects-of-noise-exposure-on-the-auditory-function-of-ovariectomized-rats-with-estrogen-deficiency
#2
Xujun Hu, Ying Wang, Chi Chuen Lau
OBJECTIVE: The benefits of estrogen for the auditory function of women depend on a number of factors. In this study, we aimed to examine the impact of noise trauma on the auditory function of ovariectomized rats with estrogen deficiency. MATERIALS AND METHODS: Twenty-eight young, female Sprague-Dawley rats were assigned to three groups (OVX+N, OVX-N, Sham+N). Rats in the OVX+N group and the OVX-N group underwent bilateral ovariectomy (OVX); the OVX+N group alone was also exposed to white noise (N) of 115 dB SPL for 8 hours a day over 14 days...
November 28, 2016: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/27878557/simple-reaction-time-for-broadband-sounds-compared-to-pure-tones
#3
Josef Schlittenlacher, Wolfgang Ellermeier, Gül Avci
Although many studies have explored the relation between reaction time (RT) and loudness, including effects of intensity, frequency, and binaural summation, comparable work on spectral summation is rare. However, most real-world sounds are not pure tones and typically have bandwidths covering several critical bands. Since comparing to a 1-kHz pure tone, the reference tone, is important for loudness measurement and standardization, the present work focuses on comparing RTs for broadband noise to those for 1-kHz pure tones in three experiments using different spectral and binaural configurations...
November 22, 2016: Attention, Perception & Psychophysics
https://www.readbyqxmd.com/read/27849549/signal-to-noise-ratio-analysis-of-a-phase-sensitive-voltmeter-for-electrical-impedance-tomography
#4
Ethan K Murphy, Mohammad Takhti, Joseph Skinner, Ryan J Halter, Kofi Odame
In this paper, thorough analysis along with mathematical derivations of the matched filter for a voltmeter used in electrical impedance tomography systems are presented. The effect of the random noise in the system prior to the matched filter, generated by other components, are considered. Employing the presented equations allow system/circuit designers to find the maximum tolerable noise prior to the matched filter that leads to the target signal-to-noise ratio (SNR) of the voltmeter, without having to over-design internal components...
November 10, 2016: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/27805061/harmine-induces-adipocyte-thermogenesis-through-rac1-mek-erk-chd4-axis
#5
Tao Nie, Xiaoyan Hui, Liufeng Mao, Baoming Nie, Kuai Li, Wei Sun, Xuefei Gao, Xiaofeng Tang, Yong Xu, Baishan Jiang, Zhengcao Tu, Peng Li, Ke Ding, Weiping Han, Shaoping Zhang, Aimin Xu, Sheng Ding, Pentao Liu, Adam Patterson, Garth Cooper, Donghai Wu
Harmine is a natural compound possessing insulin-sensitizing effect in db/db diabetic mice. However its effect on adipose tissue browning is unknown. Here we reveal that harmine antagonizes high fat diet-induced adiposity. Harmine-treated mice gained less weight on a high fat diet and displayed increased energy expenditure and adipose tissue thermogenesis. In vitro, harmine potently induced the expression of thermogenic genes in both brown and white adipocytes, which was largely abolished by inhibition of RAC1/MEK/ERK pathway...
November 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27794358/the-effects-of-click-and-masker-spectrum-on-the-auditory-brainstem-response-of-bottlenose-dolphins-tursiops-truncatus
#6
Jason Mulsow, James J Finneran, Dorian S Houser, Robert F Burkard
Two experiments were performed that investigated the effects of (1) click level and (2) continuous broadband noise on the binaural auditory brainstem response (ABR) of normal-hearing and hearing-impaired bottlenose dolphins (Tursiops truncatus). In addition to spectrally uncompensated clicks and noise, stimuli were digitally compensated to achieve "white" spectra (flat spectral density level) or "pink" spectra (spectral density level rolling off at -3 dB/octave). For experiment 1, in all spectral conditions, ABR peak latencies increased and peak amplitudes decreased with decreasing click level, but interwave intervals changed little...
October 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27775526/eeg-based-prediction-of-epileptic-seizures-using-phase-synchronization-elicited-from-noise-assisted-multivariate-empirical-mode-decomposition
#7
Dongrae Cho, Beomjun Min, Jongin Kim, Boreom Lee
In this study, we examined the phase locking value (PLV) for seizure prediction, particularly, in the gamma frequency band. We prepared simulation data and 65 clinical cases of seizure. In addition, various filtering algorithms including bandpass filtering, empirical mode decomposition, multivariate empirical mode decomposition and noise-assisted multivariate empirical mode decomposition (NA-MEMD) were used to decompose spectral components from the data. Moreover, in the case of clinical data, the PLVs were used to classify between interictal and preictal stages using a support vector machine...
October 19, 2016: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/27754182/db-03-2-renal-sympathetic-denervation-is-still-a-viable-option-for-treating-resistant-hypertension-con
#8
George Bakris
Renal denervation started out as a very promising approach to treat resistant hypertension with a very strong conceptual and basic science frame work from Gerald DiBona's lab and extending into the early non shame clinical studies demonstrating proof of concept in SYMPLICITY HTN-1 and 2. SYMPLICITY-HTN 3 a properly done, sham control trial failed to show a benefit on further reduction of BP compared to the sham group. The conclusion the procedure doesn't work. How could this be-it was clearly effective in animal models but why not in man...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27665011/evaluation-of-genetic-diversity-of-saudi-native-chicken-populations-using-microsatellite-markers
#9
M M Fathi, I Al-Homidan, M I Motawei, O K Abou-Emera, M F El-Zarei
The present study was conducted to evaluate the genetic diversity and relationships of 5 Saudi native chicken populations and a White Leghorn (L) strain as an exotic breed, using 25 microsatellite markers. According to morphological appearance and plumage color and pattern, they were classified into black (BL), black-barred (BR), dark brown (DB), light brown (LB), and gray (G) breeds. Twenty-five microsatellite markers were chosen based on the degree of polymorphism reported in the previous literature. The results revealed that all studied markers exhibited a varied percentage of polymorphism among native chicken populations...
September 24, 2016: Poultry Science
https://www.readbyqxmd.com/read/27643139/db-03-2-renal-sympathetic-denervation-is-still-a-viable-option-for-treating-resistant-hypertension-con
#10
George Bakris
Renal denervation started out as a very promising approach to treat resistant hypertension with a very strong conceptual and basic science frame work from Gerald DiBona's lab and extending into the early non shame clinical studies demonstrating proof of concept in SYMPLICITY HTN-1 and 2. SYMPLICITY-HTN 3 a properly done, sham control trial failed to show a benefit on further reduction of BP compared to the sham group. The conclusion the procedure doesn't work. How could this be-it was clearly effective in animal models but why not in man...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27628268/don-t-startle-me-interference-of-startle-probe-presentations-and-intermittent-ratings-with-fear-acquisition
#11
Rachel Sjouwerman, Johanna Niehaus, Manuel Kuhn, Tina B Lonsdorf
Reproducibility is fundamental to science and a recent matter of discussion. We report challenges for conceptual replications when employing different readout measures to target the same theoretical construct, particularly those requiring probed reactions. This was addressed in a fear conditioning paradigm, a prototype of emotional learning, in three experimental groups (Ntotal  = 57). We demonstrate that the inclusion of startle probes (95 dB burst of white noise) to elicit a startle reflex delays the acquisition of fear as reflected by skin conductance responses and intermittent fear ratings...
December 2016: Psychophysiology
https://www.readbyqxmd.com/read/27599107/the-second-blind-spot-small-retinal-vessel-vasculopathy-after-vaccination-against-neisseria-meningitidis-and-yellow-fever
#12
Stavros N Moysidis, Nicole Koulisis, Vivek R Patel, Amir H Kashani, Narsing A Rao, Mark S Humayun, Damien C Rodger
PURPOSE: To describe a case of small retinal vessel vasculopathy postvaccination. METHODS: We report the case of a 41-year-old white man who presented with a "second blind spot," describing a nasal scotoma in the right eye that started 4 days after vaccinations against Neisseria meningitidis and the yellow fever virus, and after a 2-month period of high stress and decreased sleep. Clinical examination, Humphrey visual field testing, and multimodal imaging with fundus photographs, autofluorescence, fluorescein angiography, and spectral domain optical coherence tomography and angiography were performed...
September 2, 2016: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/27588894/gain-modulation-of-cholinergic-neurons-in-the-medial-septum-diagonal-band-of-broca-through-hyperpolarization
#13
Eric D Melonakos, John A White, Fernando R Fernandez
Hippocampal network oscillations are important for learning and memory. Theta rhythms are involved in attention, navigation, and memory encoding, whereas sharp wave-ripple complexes are involved in memory consolidation. Cholinergic neurons in the medial septum-diagonal band of Broca (MS-DB) influence both types of hippocampal oscillations, promoting theta rhythms and suppressing sharp wave-ripples. They also receive frequency-dependent hyperpolarizing feedback from hippocamposeptal connections, potentially affecting their role as neuromodulators in the septohippocampal circuit...
December 2016: Hippocampus
https://www.readbyqxmd.com/read/27587142/characterization-of-zero-bias-microwave-diode-power-detectors-at-cryogenic-temperature
#14
Vincent Giordano, Christophe Fluhr, Benoît Dubois, Enrico Rubiola
We present the characterization of commercial tunnel diode low-level microwave power detectors at room and cryogenic temperatures. The sensitivity as well as the output voltage noise of the tunnel diodes is measured as functions of the applied microwave power. We highlight strong variations of the diode characteristics when the applied microwave power is higher than a few microwatts. For a diode operating at 4 K, the differential gain increases from 1000 V/W to about 4500 V/W when the power passes from -30 dBm to -20 dBm...
August 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27583659/effects-of-posture-and-stimulus-spectral-composition-on-peripheral-physiological-responses-to-loud-sounds
#15
Jennifer Koch, Jan Flemming, Thomas Zeffiro, Michael Rufer, Scott P Orr, Christoph Mueller-Pfeiffer
In the "loud-tone" procedure, a series of brief, loud, pure-tone stimuli are presented in a task-free situation. It is an established paradigm for measuring autonomic sensitization in posttraumatic stress disorder (PTSD). Successful use of this procedure during fMRI requires elicitation of brain responses that have sufficient signal-noise ratios when recorded in a supine, rather than sitting, position. We investigated the modulating effects of posture and stimulus spectral composition on peripheral psychophysiological responses to loud sounds...
2016: PloS One
https://www.readbyqxmd.com/read/27556365/human-envelope-following-responses-to-amplitude-modulation-effects-of-aging-and-modulation-depth
#16
Andrew Dimitrijevic, Jamal Alsamri, M Sasha John, David Purcell, Sahara George, Fan-Gang Zeng
OBJECTIVE: To record envelope following responses (EFRs) to monaural amplitude-modulated broadband noise carriers in which amplitude modulation (AM) depth was slowly changed over time and to compare these objective electrophysiological measures to subjective behavioral thresholds in young normal hearing and older subjects. DESIGN: HASH(0x4e12eb0) PARTICIPANTS: three groups of subjects included a young normal-hearing group (YNH 18 to 28 years; pure-tone average = 5 dB HL), a first older group ("O1"; 41 to 62 years; pure-tone average = 19 dB HL), and a second older group ("O2"; 67 to 82 years; pure-tone average = 35 dB HL)...
September 2016: Ear and Hearing
https://www.readbyqxmd.com/read/27552261/prevalence-of-hearing-loss-by-severity-in-the-united-states
#17
Adele M Goman, Frank R Lin
OBJECTIVES: To estimate the age- and severity-specific prevalence of hearing impairment in the United States. METHODS: We conducted cross-sectional analyses of 2001 through 2010 data from the National Health and Nutrition Examination Survey on 9648 individuals aged 12 years or older. Hearing loss was defined as mild (> 25 dB through 40 dB), moderate (> 40 dB through 60 dB), severe (> 60 dB through 80 dB), or profound (> 80 dB). RESULTS: An estimated 25...
October 2016: American Journal of Public Health
https://www.readbyqxmd.com/read/27551319/metallothioneins-1-and-2-but-not-3-are-regulated-by-nutritional-status-in-rat-white-adipose-tissue
#18
Sylwia Szrok, Ewa Stelmanska, Jacek Turyn, Aleksandra Bielicka-Gieldon, Tomasz Sledzinski, Julian Swierczynski
BACKGROUND: Cumulating evidence underlines the role of adipose tissue metallothionein (MT) in the development of obesity and type 2 diabetes. Fasting/refeeding was shown to affect MT gene expression in the rodent liver. The influence of nutritional status on MT gene expression in white adipose tissue (WAT) is inconclusive. The aim of this study was to verify if fasting and fasting/refeeding may influence expression of MT genes in WAT of rats. RESULTS: Fasting resulted in a significant increase in MT1 and MT2 gene expressions in retroperitoneal, epididymal, and inguinal WAT of rats, and this effect was reversed by refeeding...
2016: Genes & Nutrition
https://www.readbyqxmd.com/read/27551318/dibutyryl-camp-affecting-fat-deposition-of-finishing-pigs-by-decreasing-the-inflammatory-system-related-to-insulin-sensitive-or-lipolysis
#19
Xianyong Ma, Wei Fang, Zongyong Jiang, Li Wang, Xuefen Yang, Kaiguo Gao
BACKGROUND: The mechanism of db-cAMP regulating fat deposition and improving lean percentage is unclear and needs to be further studied. METHODS: Eighteen 100-day-old Duroc × Landrance × Large White barrows (49.75 ± 0.75 kg) were used for experiment 1, and 15 eighteen 135-day-old barrows (78.34 ± 1.22 kg) were used for experiment 2 to investigate the effects of dietary dibutyryl-cAMP (db-cAMP) on fat deposition in finishing pigs. Pigs were fed with a corn-soybean meal-based diet supplemented with 0 or 15 mg/kg db-cAMP, and both experiments lasted 35 days, respectively...
2016: Genes & Nutrition
https://www.readbyqxmd.com/read/27530729/effect-of-pioglitazone-on-metabolic-features-in-endotoxemia-model-in-obese-diabetic-db-db-mice
#20
Manoranjan Sharma, Jogeswar Mohapatra, Umar Malik, Jignesh Nagar, Abhijit Chatterjee, Balaraman Ramachandran, Mukul R Jain
BACKGROUND: Infectious diseases are more frequent in diabetic patients, leading to increased morbidity and mortality. Endotoxemia affects glucose metabolism and lipolytic capacity. The aims of the present study were to determine whether endotoxemia exacerbates metabolic features (adipose inflammation, adipogenesis, and insulin resistance [IR]) in an animal model of diabetes (i.e. db/db mice) after acute infection and the effects of pioglitazone. METHODS: Female db/db mice treated with pioglitazone (3 and 30 mg/kg, p...
July 22, 2016: Journal of Diabetes
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