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https://www.readbyqxmd.com/read/28821277/the-feasibility-analysis-of-omission-of-elective-irradiation-to-level-ib-lymph-nodes-in-low-risk-nasopharyngeal-carcinoma-based-on-the-2013-updated-consensus-guideline-for-neck-nodal-levels
#1
Xiaomin Ou, Yibing Miao, Xiaoshen Wang, Jianhui Ding, Xiayun He, Chaosu Hu
BACKGROUND: Level IB metastasis is rare in nasopharyngeal carcinoma (NPC). The purpose of this study is to investigate the high-risk factors for level IB metastasis and evaluate the feasibility of omission of elective irradiation to level IB in the low-risk subgroups in NPC. METHODS: This retrospective study identified 532 patients with NPC treated by definitive radiation in our institution from 2009 to 2010. Level IB nodes were electively irradiated based on the physician's decision...
August 18, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28797461/the-importance-of-log-odds-of-positive-lymph-nodes-for-locoregional-recurrence-in-oral-squamous-cell-carcinoma
#2
Ali-Farid Safi, Martin Kauke, Andrea Grandoch, Hans-Joachim Nickenig, Uta Drebber, Joachim Zöller, Matthias Kreppel
OBJECTIVES: Log odds of positive lymph nodes (LODDS) has been demonstrated as a very promising staging model for multiple cancer sites, as it avoids singularity and predicts prognosis significantly better than conventional nodal staging and lymph node ratio. However, published studies on the influence of LODDS for patients with OSCC are very seldom. MATERIAL AND METHODS: Retrospective chart review of 499 patients with treatment-naive oral squamous cell carcinoma...
September 2017: Oral Oncology
https://www.readbyqxmd.com/read/28751709/lymph-node-ratio-is-associated-with-adverse-clinicopathological-features-and-is-a-crucial-nodal-parameter-for-oral-and-oropharyngeal-cancer
#3
Zhien Feng, Qiao Shi Xu, Chong Wang, Jin Zhong Li, Ming Hui Mao, Hua Li, Li Zheng Qin, Zhengxue Han
The lymph node ratio(LNR) has been described as a novel predictor of the survival of patients with oral and oropharyngeal squamous cell carcinoma(O/OPSCC). The purpose of this study was to evaluate whether LNR is better at predicting survival and the need for adjuvant treatment than traditional tumour-nodal-metastasis(TNM) staging. Eight hundred nine patients with O/OPSCC and positive lymph node disease were retrospectively enrolled in this study. LNR equal to 0.075 is the best cut-off value for stratifying 5-year disease-free survival(DFS)...
July 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28747140/mitochondrial-assembly-receptor-expression-is-an-independent-prognosticator-for-patients-with-oral-tongue-squamous-cell-carcinoma
#4
Yan-Ye Su, Chang-Han Chen, Chih-Yen Chien, Wei-Che Lin, Wan-Ting Huang, Shau-Hsuan Li
INTRODUCTION: Recent evidence suggests that the local renin-angiotensin system has been implicated in various malignancies. The mitochondrial assembly receptor is a newly identified receptor for angiotensin peptides, angiotensin-(1-7), and has an important role in the renin-angiotensin system. However, the role of the mitochondrial assembly receptor in the prognosis of cancer patients remains unclear. The aim of this study was to evaluate the significance of mitochondrial assembly receptor signaling in the prognosis of oral tongue squamous cell carcinoma...
July 2017: Journal of the Renin-angiotensin-aldosterone System: JRAAS
https://www.readbyqxmd.com/read/28738193/degree-of-keratinization-is-an-independent-prognostic-factor-in-oral-squamous-cell-carcinoma
#5
Susanne Wolfer, Stefan Elstner, Stefan Schultze-Mosgau
PURPOSE: Keratinization is a routinely reported histologic feature in head and neck cancer. In contrast to numerous clinicopathologic parameters, the prognostic value of keratinization in oral squamous cell carcinoma (OSCC) is rarely reported in the literature. The purpose of this study was to review the outcome of patients with OSCC with a special focus on the degree of keratinization. PATIENTS AND METHODS: In this retrospective cohort study, we evaluated the medical records at the Department of Oral and Maxillofacial Surgery, Jena University Hospital, and investigated the outcome of patients with OSCC with disease-free survival and disease-specific survival according to the degree of keratinization...
June 30, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28714274/the-relevance-of-the-lymph-node-ratio-as-predictor-of-prognosis-is-higher-in-hpv-negative-than-in-hpv-positive-oropharyngeal-squamous-cell-carcinoma
#6
Moritz F Meyer, Jeannine Meinrath, Julia Seehawer, Axel Lechner, Margarete Odenthal, Alexander Quaas, Robert Semrau, Christian U Huebbers, Simone Marnitz, Reinhard Büttner, Dirk Beutner
OBJECTIVES: Lymph node ratio (LNR) is an established predictor in different entities of carcinoma, including head and neck malignancies. In oropharyngeal squamous cell carcinoma (OPSCC), lymph node involvement differs between Human Papilloma Virus (HPV)-positive and negative tumours. Herein, we evaluate the impact of HPV association on the concept of LNR. METHODS: 88 surgically treated patients were included in this retrospective chart review. HPV-positive and negative OPSCC were evaluated for prediction of outcome by LNR separately...
July 17, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28687157/the-pattern-of-failure-and-predictors-of-locoregional-control-in-lateralized-buccogingival-cancer-after-postoperative-radiation-therapy
#7
Tzu-Yu Lai, Yu-Wen Hu, Yu-Ming Liu, Yi-Wei Chen, Cheng-Ying Shiau, Pen-Yuan Chu, Shyh-Kuan Tai, Wen-Liang Lo, Cheng-Hsien Wu, Ling-Wei Wang
BACKGROUND: To evaluate the failure pattern and identify predictors of locoregional control in lateralized buccogingival cancer after postoperative radiotherapy (RT) at a single institution. METHODS: We retrospectively reviewed the clinical data of 150 patients with lateralized oral squamous cell carcinoma, including carcinoma of the buccal mucosa, gingiva and retromolar trigone. All patients underwent radical surgery followed by postoperative RT with or without concurrent chemotherapy...
July 4, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/28683842/using-3-tesla-magnetic-resonance-imaging-in-the-pre-operative-evaluation-of-tongue-carcinoma
#8
K F Moreno, R S Cornelius, F V Lucas, J Meinzen-Derr, Y J Patil
OBJECTIVE: This study aimed to evaluate the role of 3 Tesla magnetic resonance imaging in predicting tongue tumour thickness via direct and reconstructed measures, and their correlations with corresponding histological measures, nodal metastasis and extracapsular spread. METHODS: A prospective study was conducted of 25 patients with histologically proven squamous cell carcinoma of the tongue and pre-operative 3 Tesla magnetic resonance imaging from 2009 to 2012...
July 7, 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28681422/prognostic-indicators-and-survival-in-salvage-surgery-for-laryngeal-cancer
#9
Kyle T Fletcher, Thomas J Gal, Andrew J Ebelhar, Joseph Valentino, Yolanda M Brill, Emily V Dressler, Rony K Aouad
BACKGROUND: Perineural invasion (PNI) and lymphovascular invasion (LVI) are known to be poor prognostic indicators in primary surgery. The purpose of this study was to determine their impact on survival in the setting of salvage laryngectomy. METHODS: We conducted a retrospective review of patients who underwent salvage laryngectomy between 2006 and 2014. RESULTS: Seventy-eight patients were included in this study; PNI was diagnosed in 48 patients (61...
July 6, 2017: Head & Neck
https://www.readbyqxmd.com/read/28635214/-clinicopathological-characteristics-of-papillary-thyroid-microcarcinoma-and-risk-factors-for-central-lymph-node-metastasis
#10
Y L Wu, J M Sun, J J Zhang, Q X Cui, W H Zheng, X R Li
Objective: To analyze the clinicopathological characteristics of papillary thyroid microcarcinoma (PTMC) and risk factors for central lymph node metastasis(CLNM) in PTMC. Methods: The data of 900 patients with PTMC initially treated in our hospital from January 2004 to December 2015 were retrospectively analyzed. Chi-square test and Logistic regression analysis were performed to determine the risk factors for CLNM. Results: CLNM affected 162 (22.9%) of 707 patients treated with central lymph node dissection...
June 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/28627989/computed-tomography-detection-of-extracapsular-spread-of-squamous-cell-carcinoma-of-the-head-and-neck-in-metastatic-cervical-lymph-nodes
#11
Joshua A Carlton, Adam W Maxwell, Lyndsey B Bauer, Sara M McElroy, Lester J Layfield, Humera Ahsan, Ajay Agarwal
Background and purpose In patients with squamous cell carcinoma of the head and neck (HNSCC), extracapsular spread (ECS) of metastases in cervical lymph nodes affects prognosis and therapy. We assessed the accuracy of intravenous contrast-enhanced computed tomography (CT) and the utility of imaging criteria for preoperative detection of ECS in metastatic cervical lymph nodes in patients with HNSCC. Materials and methods Preoperative intravenous contrast-enhanced neck CT images of 93 patients with histopathological HNSCC metastatic nodes were retrospectively assessed by two neuroradiologists for ECS status and ECS imaging criteria...
June 2017: Neuroradiology Journal
https://www.readbyqxmd.com/read/28622888/validation-of-the-pathological-classification-of-lymph-node-metastasis-for-head-and-neck-tumors-according-to-the-8th-edition-of-the-tnm-classification-of-malignant-tumors
#12
Jacinto García, Montserrat López, Laura López, Silvia Bagué, Esther Granell, Miquel Quer, Xavier León
OBJECTIVES: One of the main changes in the 8th edition of the TNM Classification for head and neck tumors is the inclusion of extracapsular spread (ECS) as a criterion for evaluating the regional extension, both clinical (cN) and pathological (pN). The objective of our study is to evaluate the prognostic capacity derived from the inclusion of the ECS in the pathological classification of head and neck squamous cell carcinoma (HNSCC) patients treated with a neck dissection, as established by the 8th edition TNM Classification...
July 2017: Oral Oncology
https://www.readbyqxmd.com/read/28622689/prognostic-impact-and-implications-of-extracapsular-lymph-node-spread-in-borrmann-type-iv-gastric-cancer
#13
Rui-Zeng Dong, Jian-Min Guo, Ze-Wei Zhang, Yi-Min Zhou, Ying Su
The purpose of this study was to evaluate the relationship between extracapsular lymph node spread (ECS) and clinicopathology and its influence on the prognosis in patients with Borrmann type IV gastric cancer. Between 2002 and 2014, clinical data were reviewed from 486 patients with Borrmann type IV gastric cancer who underwent curative resection. Of the 486 patients, lymph node metastasis was found in 456. ECS was detected in 213 (46.7%) patients with lymph node metastasis. A positive lymph node with ECS was significantly correlated with the N category, lymphatic/venous invasion, tumor location, and TNM stage...
June 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28608748/tympanic-membrane-and-ossicular-sparing-modified-lateral-temporal-bone-resection
#14
Yaser Ghavami, Yarah M Haidar, Marlon Maducdoc, Tjoson Tjoa, Omid Moshtaghi, Harrison W Lin, Hamid R Djalilian
A modified lateral temporal bone resection (mLTBR) is a unique technique that spares the tympanic membrane (TM) and ossicles in select patients with squamous cell carcinoma (SCCa). The records of 5 patients with SCCa of the temporal bone with negative frozen-section biopsy at the tympanic annulus were reviewed. The mean follow-up time for the patients was 29.2 months. One patient received postoperative radiation due to cervical nodal extracapsular spread. All patients were recurrence free as of the most recent follow-up (range, 8-50 months)...
June 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28580699/prognostic-value-of-lymphovascular-invasion-of-the-primary-tumor-in-hypopharyngeal-carcinoma-after-total-laryngopharyngectomy
#15
Yuki Saito, Go Omura, Kazuo Yasuhara, Ryoko Rikitake, Ken Akashi, Osamu Fukuoka, Masafumi Yoshida, Mizuo Ando, Takahiro Asakage, Tatsuya Yamasoba
BACKGROUND: We aimed to determinate the prognostic value of lymphovascular invasion in the specimens resected during total laryngopharyngectomy for hypopharyngeal carcinoma. METHODS: Patients who underwent total laryngopharyngectomy at our institution between 2004 and 2014 were included in this study and retrospectively analyzed. We then discriminated for vascular invasion and lymphatic invasion of the primary tumor in all cases. RESULTS: We reviewed 135 records (120 men and 15 women; age range, 36-84 years)...
August 2017: Head & Neck
https://www.readbyqxmd.com/read/28570758/variation-in-use-of-postoperative-chemoradiation-following-surgery-for-t1-and-t2-oropharyngeal-squamous-cell-carcinoma-national-cancer-database
#16
Benjamin R Roman, Shrujal S Baxi, Jennifer R Cracchiolo, Timothy J Blackwell, David G Pfister, Sean McBride, Ian Ganly, Jatin P Shah, Snehal G Patel, Luc G Morris, Marc A Cohen
BACKGROUND AND OBJECTIVES: Primary surgical treatment of patients with early T-classification (T1-T2) oropharyngeal squamous cell carcinoma (OPSCC) has increased. We sought to determine how often these patients receive postoperative chemoradiation (CRT). METHODS: Patients with T1-T2 OPSCC in the National Cancer Database who underwent primary surgery were evaluated for receipt of postoperative CRT. Postoperative CRT use was examined among patients with high risk factors (positive margins and/or extracapsular spread [ECS]), intermediate risk factors (negative margins, no ECS, and either pT3-4 and/or N2-N3), and no apparent risk factors...
September 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28450437/solid-lymph-nodes-as-an-imaging-biomarker-for-risk-stratification-in-human-papillomavirus-related-oropharyngeal-squamous-cell-carcinoma
#17
T J Rath, S Narayanan, M A Hughes, R L Ferris, S I Chiosea, B F Branstetter
BACKGROUND AND PURPOSE: Human papillomavirus-related oropharyngeal squamous cell carcinoma is associated with cystic lymph nodes on CT and has a favorable prognosis. A subset of patients with aggressive disease experience treatment failure. Our aim was to determine whether the extent of cystic lymph node burden on staging CT can serve as an imaging biomarker to predict treatment failure in human papillomavirus-related oropharyngeal squamous cell carcinoma. MATERIALS AND METHODS: We identified patients with human papilloma virus-related oropharyngeal squamous cell carcinoma and staging neck CTs...
April 27, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28428211/imaging-manifestations-of-pseudoprogression-in-metastatic-melanoma-nodes-injected-with-talimogene-laherparepvec-initial-experience
#18
C Zamora, M Lopez, F Cunningham, F Collichio, M Castillo
Talimogene laherparepvec is an oncolytic virus recently approved for targeted treatment of advanced melanoma. Because of an inflammatory reaction, treated lesions may increase in size and develop infiltrative margins that can be construed as disease progression or extracapsular spread. In this report, we describe our initial experience imaging the response of metastatic nodes injected with talimogene laherparepvec. Six of 12 nodes (50%) showed growth from baseline followed by decreased size, 5 of 12 nodes (42%) showed a downward size trend, and 1 node showed continued increase in size...
April 20, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28351561/salvage-surgery-in-recurrent-head-and-neck-squamous-cell-carcinoma-oncologic-outcome-and-predictors-of-disease-free-survival
#19
Marc Hamoir, Emma Holvoet, Jerôme Ambroise, Benoît Lengelé, Sandra Schmitz
OBJECTIVE: Salvage surgery in recurrent SCCHN is associated with poor outcomes. This study aimed to better identify suitable surgical candidates and those at high risk of new recurrence. MATERIALS AND METHODS: Single-center retrospective analysis of 109 patients undergoing salvage surgery for recurrent SCCHN. Univariate and multivariate analyses were used to identify prognostic factors affecting disease-free survival (DFS). RESULTS: The following factors showed a significant impact on DFS: Disease-free interval >6months [HR 0...
April 2017: Oral Oncology
https://www.readbyqxmd.com/read/28347602/prognostic-significance-of-extracapsular-spread-of-lymph-node-metastasis-from-oral-squamous-cell-carcinoma-in-the-clinically-negative-neck
#20
P Suton, I Salaric, M Granic, D Mueller, I Luksic
The presence of extracapsular spread (ECS) in patients with oral squamous cell carcinoma (OSCC) indicates a poor prognosis and is associated with a higher risk of regional recurrence and distant metastasis. The aim of this study was to analyse this important feature of cervical lymph nodes in the clinically node-negative setting. The study included 61 patients with clinically T1-T3N0 OSCC who underwent primary surgical treatment; 52 were male and nine were female, and their median age was 57 years. The 5-year disease-free survival, disease-specific survival, and overall survival rates were 30...
March 24, 2017: International Journal of Oral and Maxillofacial Surgery
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