Read by QxMD icon Read

Extracapsular spread

E Metcalfe, L Aspin, R Speight, E Ermiş, S Ramasamy, K Cardale, K E Dyker, M Sen, R J D Prestwich
AIMS: To determine outcomes after adjuvant radiotherapy for squamous cell carcinoma of the oral cavity and to correlate locoregional recurrence patterns with radiotherapy target volumes. MATERIALS AND METHODS: All patients receiving adjuvant radiotherapy±chemotherapy after surgery with curative intent for oral cavity squamous cell carcinoma between 2007 and 2012 were retrospectively analysed. Locoregional recurrences were reconstructed on the planning computed tomography scan by both deformable image co-registration and by visual assessment...
October 3, 2016: Clinical Oncology: a Journal of the Royal College of Radiologists
Daan Nevens, Olivier Vantomme, Annouschka Laenen, Robert Hermans, Sandra Nuyts
OBJECTIVES: The purpose of this study is to make a prognostic model for regional relapse in head and neck cancer using clinical and Computed Tomography (CT) parameters. METHODS: 183 patients with lymph node-positive head and neck cancer were treated between 2002 and 2012 with radiotherapy or concurrent chemoradiotherapy. CT studies pre- and post-treatment were reviewed for lymph node size and presence of necrosis, extracapsular spread and calcifications. For every patient, correlations with 3 year regional control (RC), metastasis free survival (MFS), disease free survival (DFS) and overall survival (OS) were made...
October 6, 2016: British Journal of Radiology
Claus Wittekindt, Jens Peter Klussmann
The current TNM staging for oropharyngeal cancer (OSCC) was designed empirically for non-HPV-related disease. Emerging evidence suggests it is unsuited for Human papillomavirus (HPV)-related OSCC. Patients with HPV-positive tumors have improved prognosis, despite presenting at advanced stages. These shortcomings of the current staging system have been identified in single- and multi-institutional trials. Patients with HPV related OSCC typically present with advanced N-stages leading to higher stage groupings...
2017: Recent Results in Cancer Research
S M Lagarde, M Navidi, S S Gisbertz, H W M van Laarhoven, K Sumpter, S L Meijer, B Disep, A Immanuel, S M Griffin, M I van Berge Henegouwen
BACKGROUND: The significance of extracapsular lymph node involvement (LNI) is unclear in patients with oesophageal cancer who have undergone neoadjuvant treatment followed by oesophagectomy. The aim of this study was to assess the incidence and prognostic significance of extracapsular LNI in a large multicentre series of consecutive patients with oesophageal cancer treated by neoadjuvant chemotherapy or chemoradiotherapy and surgery. METHODS: Data from a consecutive series of patients treated at two European centres were analysed...
October 3, 2016: British Journal of Surgery
M S Chung, K L Cheng, Y J Choi, J L Roh, Y S Lee, S S Lee, J H Lee, J H Baek
AIM: To determine the interobserver reproducibility of measuring cervical lymph nodes at computed tomography (CT) in patients with head and neck squamous cell carcinoma (HNSCC) and to investigate the influence of finding extracapsular spread (ECS) at CT on measurement reliability. MATERIALS AND METHODS: The institutional review board approved the study protocol, and informed consent was obtained. A total of 146 patients with 224 suspicious lymph nodes underwent CT before treatment...
August 25, 2016: Clinical Radiology
C G Navarro-Locsin, A M V Chang, M L Daroy, A C Alfon, J J Andal, P F Padua
UNLABELLED: BRAF V600E is a possible biomarker for risk stratification and prognostication in papillary thyroid carcinoma. Studies on its association with aggressive clinicopathological features among East Asian populations are limited. This study examines the clinical and histopathological features of this mutation in Filipinos with conventional papillary thyroid carcinoma. METHODS: Formalin-fixed, paraffin embedded thyroid tissue blocks of papillary carcinoma for the study period January 2010 to December 2012 were retrieved...
August 2016: Malaysian Journal of Pathology
Xavier León, Antoni Rigó, Nuria Farré, Montserrat López, Jacinto García, Julia de Juan, Miquel Quer
Few studies have analyzed the appearance of extracapsular spread (ECS) in salvage neck dissections carried out after regional recurrence of the disease. The aim of our study was to evaluate the frequency of ECS in patients with an isolated regional recurrence treated with a salvage neck dissection, and to assess the influence of ECS on prognosis. We conducted a retrospective study of 123 patients treated with a salvage neck dissection. Eighty-two patients (66.7 %) had nodes with ECS. Five-year salvage-specific survival for patients without ECS was 77...
August 10, 2016: European Archives of Oto-rhino-laryngology
P Garzino-Demo, E Zavattero, P Franco, M Fasolis, G Tanteri, A Mettus, P Tosco, L Chiusa, M Airoldi, O Ostellino, M Schena, M Rampino, U Ricardi, A Evangelista, F Merletti, S Berrone, G Ramieri
PURPOSE: This report analyzed the outcomes of patients undergoing surgery for oral squamous cell carcinoma (OSCC) to identify the value of prognostic factors. MATERIAL AND METHODS: A total of 525 patients were studied who had undergone surgery for oral squamous cell carcinoma (OSCC) between 2000 and 2011, of whom 222 had received postoperative radiation-therapy (PORT) and or chemoradiation-therapy (PORTC). For each patient, personal data, histological findings, treatment and outcome were recorded and analyzed statistically...
September 2016: Journal of Cranio-maxillo-facial Surgery
A Pauzie, M Gavid, J-M Dumollard, A Timoshenko, M Peoc'h, J-M Prades
OBJECTIVES: Supracentimetric cervical lymph node metastasis is classically a poor prognostic factor for locoregional recurrence and survival in head and neck cancer. Causality, however, is more controversial for infracentimetric cervical lymph node metastases. The objective of this study was to evaluate the incidence and prognostic value of infracentimetric lymph node metastasis. MATERIALS AND METHODS: Two hundred and forty-three neck dissections from 150 head and neck cancer patients were analyzed...
July 27, 2016: European Annals of Otorhinolaryngology, Head and Neck Diseases
Maxime Mermod, Massimo Bongiovanni, Tatiana V Petrova, Elena A Dubikovskaya, Christian Simon, Genrich Tolstonog, Yan Monnier
BACKGROUND: The correlation between podoplanin expression and extracapsular spread in head and neck squamous cell carcinoma (HNSCC) has never been reported. The purpose of this study was to assess the predictive value of podoplanin expression for this parameter. METHODS: Subjective immunoreactivity scores and semiquantitative image analysis of podoplanin expression were performed in 67 patients with primary oral squamous cell carcinoma and in their corresponding lymph nodes...
July 20, 2016: Head & Neck
Evan M Graboyes, Melanie E Townsend, Dorina Kallogjeri, Jay F Piccirillo, Brian Nussenbaum
Importance: Quality metrics for patients with laryngeal squamous cell carcinoma (SCC) exist, but whether compliance with these metrics correlates with improved survival is unknown. Objective: To examine whether compliance with proposed quality metrics is associated with improved survival in patients with laryngeal SCC treated with surgery with or without adjuvant therapy. Design, Setting, and Participants: This retrospective cohort study included patients from a tertiary care academic medical center who had previously untreated laryngeal SCC and underwent surgery with or without adjuvant therapy from January 1, 2003, through December 31, 2012...
July 19, 2016: JAMA Otolaryngology—Head & Neck Surgery
Mei Li, Xiao-Guang Huang, Zhi-Ning Yang, Jia-Yang Lu, Yi-Zhou Zhan, Wen-Jia Xie, Dong-Jie Zhou, Li Wang, Di-Xia Zhu, Zhi-Xiong Lin
OBJECTIVE: To investigate the need for elective neck irradiation (ENI) to nodal Level IB in patients with nasopharyngeal carcinoma (NPC) with negative Level IB lymph nodes (IB-negative) treated by intensity-modulated radiotherapy (IMRT). METHODS: We conducted a Phase 2 prospective study in 123 newly diagnosed IB-negative patients with NPC treated by IMRT, who met at least 1 of the following criteria: (1) unilateral or bilateral Level II involvement with 1 of the following: Level IIA involvement or any Level II node ≥2 cm/with extracapsular spread; (2) ≥2 unilateral node-positive regions...
September 2016: British Journal of Radiology
Hidenori Suzuki, Takuma Matoba, Nobuhiro Hanai, Daisuke Nishikawa, Yujiro Fukuda, Yusuke Koide, Yasuhisa Hasegawa
The lymph node density (LND) has been reported to be a significant prognostic factor in various types of carcinoma. This study investigated whether the LND is associated with survival in patients with hypopharyngeal squamous cell carcinoma (HPSCC) who have positive lymph nodes without distant metastasis. Forty-six patients who were pathologically diagnosed with HPSCC with positive lymph nodes and without distant metastasis were enrolled in this study. The LND was defined as the ratio of positive lymph nodes to the total number of lymph nodes...
July 2, 2016: European Archives of Oto-rhino-laryngology
Y Xu, M Zhang, Q Yue, J Zong, J Lin, R Sun, S Qiu, S Lin, J Pan
PURPOSE: Periparotid recurrence is an uncommon phenomenon after intensity-modulated radiotherapy (IMRT) for nasopharyngeal carcinoma. This study aimed to discuss the clinical characteristics, reasonable causes and feasible therapeutic modalities of patients with nasopharyngeal carcinoma and periparotid recurrence. PATIENTS AND METHODS: The medical records of 1852 patients with non-metastatic nasopharyngeal carcinoma treated with initial IMRT between January 2008 and December 2012 were retrospectively reviewed, and nine patients were finally found to have developed periparotid recurrence after IMRT...
July 2016: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
Faya Liang, Song Fan, Ping Han, Qian Cai, Peiliang Lin, Renhui Chen, Shitong Yu, Xiaoming Huang
BACKGROUND: Primary tumors of early-stage (T1-2N0M0) head and neck squamous cell carcinoma (HNSCC) can be treated by transoral minimally invasive surgery, but the cervical lymph node lacks corresponding minimally invasive treatment. Therefore, our study was to evaluate the safety and effectiveness of endoscopic-assisted selective neck dissection (EASND) via small lateral neck incision in treatment of early-stage HNSCC. METHODS: From May 2008 to April 2012, 29 patients with early-stage HNSCC were enrolled in this retrospective study...
July 1, 2016: Surgical Endoscopy
Chi-Sheng Wu, Kai-Ping Chang, Chun-Nan OuYang, Huang-Kai Kao, Chuen Hsueh, Lih-Chyang Chen, Hsiao-Yun Cheng, Ying Liang, Willisa Liou, Chih-Lung Liang, Yu-Sun Chang
ASC (Apoptosis-associated speck-like protein containing a CARD) acts as a platform protein in the inflammasome cascade of some cancer types. However, its potential involvement in OSCC (oral cavity squamous cell carcinoma) has not yet been determined. Here, we investigated the potential role of ASC in OSCC. RT-qPCR analysis of 20 paired tumor and adjacent normal tissue samples revealed that the mRNA levels of ASC, along with IL-1β, CASP1, and NLRP3 in ASC-associated NLRP3 inflammasome were significantly elevated in OSCC tissues...
June 29, 2016: Oncotarget
Bing-Shen Huang, Wan-Yu Chen, Cheng-En Hsieh, Chien-Yu Lin, Li-Yu Lee, Ku-Hao Fang, Ngan-Ming Tsang, Chung-Jan Kang, Hung-Ming Wang, Joseph Tung-Chieh Chang
OBJECTIVE: To evaluate the outcomes and prognostic factors in patients with parotid gland cancers treated with adjuvant radiotherapy with or without chemotherapy. METHODS: Eighty-five patients with parotid gland cancers were identified between October 2001 and September 2011. The median radiation dose was 66 Gy (range, 9-76 Gy). The outcomes assessment included overall survival, locoregional control, distant metastasis-free survival and disease-free survival. RESULTS: The stage distribution was 20 patients  (23...
September 2016: Japanese Journal of Clinical Oncology
Nina Lapke, Yen-Jung Lu, Chun-Ta Liao, Li-Yu Lee, Chien-Yu Lin, Hung-Ming Wang, Shu-Hang Ng, Shu-Jen Chen, Tzu-Chen Yen
TP53 mutations have been linked to reduced survival in patients with oral cavity squamous cell carcinoma (OSCC). However, the impact of different types of TP53 mutations remains unclear. Here, we demonstrate that the carriage of missense mutations in the TP53 DNA binding domain (DBD missense mutations) is associated with decreased disease-specific survival (DSS) compared with wild-type TP53 (P=0.002) in a cohort of 345 OSCC patients. In contrast, DSS of patients bearing all of the remaining TP53 mutations did not differ from that observed in wild-type TP53 patients (P=0...
June 8, 2016: Oncotarget
Wolfgang P Fendler, Dorothea F Schmidt, Vera Wenter, Kolja M Thierfelder, Christian Zach, Christian Stief, Peter Bartenstein, Thomas Kirchner, Franz J Gildehaus, Christian Gratzke, Claudius Faber
: We evaluated the accuracy of (68)Ga-PSMA-HBED-CC ((68)Ga-PSMA) positron emission tomography/computed tomography (PET/CT) to localize cancer in the prostate and surrounding tissue at initial diagnosis. METHODS: Twenty-one patients with biopsy-proven prostate cancer (PCa) underwent (68)Ga-PSMA PET/CT at a median of 4 (range: 0 to 47) days prior to radical prostatectomy. Based on a 6-segment model, the Gleason score (GS) and segmental tumor burden (STBHP) as determined by histopathology were correlated with maximum standardized uptake value (SUVmax) and tumor burden as determined by different SUV cut-off values for (68)Ga-PSMA PET (STBPET1-6)...
June 3, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Neil Gildener-Leapman, Jeehong Kim, Shira Abberbock, Garret W Choby, Rajarsi Mandal, Umamaheswar Duvvuri, Robert L Ferris, Seungwon Kim
BACKGROUND: The purpose of this study was to describe how the up-front transoral robotic surgery (TORS) approach could be used to individually tailor adjuvant therapy based on surgical pathology. METHODS: Between January 2009 and December 2013, 76 patients received TORS for oropharyngeal squamous cell carcinoma (OPSCC). Clinical predictors of adjuvant therapy were analyzed and comparisons were made between recommended treatment guidelines for up-front surgery versus definitive nonsurgical approaches...
August 2016: Head & Neck
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"