Yueqin Hong, Yiyi Chen, Junxiong Zhang, Hao Zhang, Zhengan Wang, Feng Zhao, Lu Sun, Mengzhen Chen, Feiteng Zhu, Hemu Zhuang, Shengnan Jiang, Yunsong Yu, Yan Chen
AIMS: Fosfomycin has regained attention for treating infections caused by methicillin-resistant Staphylococcus aureus and multidrug-resistant coagulase-negative staphylococci. In this research, our objective was to investigate the mechanisms underlying fosfomycin resistance in Staphylococcus capitis. METHODS: The minimum inhibitory concentrations (MICs) of fosfomycin were assessed in 109 clinical S. capitis isolates by the agar dilution method. By cloning the fos-like genes into the shuttle vector, pTSSCm-Pcap, and observing the change in fosfomycin MICs, the gene function was verified...
March 30, 2024: International Journal of Antimicrobial Agents