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https://www.readbyqxmd.com/read/29667069/the-versatile-role-of-exosomes-in-cancer-progression-diagnostic-and-therapeutic-implications
#1
REVIEW
Vignesh Sundararajan, Fazlul H Sarkar, Thamil Selvee Ramasamy
BACKGROUND: Recent advances in cancer biology have highlighted the relevance of exosomes and nanovesicles as carriers of genetic and biological messages between cancer cells and their immediate and/or distant environments. It has been found that these molecular cues may play significant roles in cancer progression and metastasis. Cancer cells secrete exosomes containing diverse molecules that can be transferred to recipient cells and/or vice versa to induce a plethora of biological processes, including angiogenesis, metastasis formation, therapeutic resistance, epithelial-mesenchymal transition and epigenetic/stemness (re)programming...
April 17, 2018: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/29665849/an-innovative-immunotherapeutic-strategy-for-ovarian-cancer-clec10a-and-glycomimetic-peptides
#2
Laura L Eggink, Katherine F Roby, Robert Cote, J Kenneth Hoober
BACKGROUND: Receptors specific for the sugar N-acetylgalactosamine (GalNAc) include the human type II, C-type lectin receptor macrophage galactose-type lectin/C-type lectin receptor family member 10A (MGL/CLEC10A/CD301) that is expressed prominently by human peripheral immature dendritic cells, dendritic cells in the skin, alternatively-activated (M2a) macrophages, and to lesser extents by several other types of tissues. CLEC10A is an endocytic receptor on antigen-presenting cells and has been proposed to play an important role in maturation of dendritic cells and initiation of an immune response...
April 17, 2018: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/29665421/uhplc-q-tof-ms-ms-based-screening-and-identification-of-the-metabolites-in-vivo-after-oral-administration-of-betulin
#3
Wendan Zhang, Honghong Jiang, Miaomiao Jin, Qiao Wang, Qian Sun, Yingfeng Du, Liang Cao, Huijun Xu
Betulin is an active natural pentacyclic triterpene ingredient with valuable anti-cancer and anti-HIV efficacies. In the present study, an efficient approach was developed to screening and identification of metabolites and to assess the metabolic profiles of betulin in vivo using UHPLC-Q-TOF-MS/MS system based on multiple mass defect filter data acquisition (MMDF) and multiple data processing techniques. Based on the proposed method, 56 phase I and 6 phase II metabolites were detected in rats after oral administration of betulin...
April 14, 2018: Fitoterapia
https://www.readbyqxmd.com/read/29665144/disulfiram-copper-targets-stem-cell-like-aldh-population-of-multiple-myeloma-by-inhibition-of-aldh1a1-and-hedgehog-pathway
#4
Na Jin, Xiaojian Zhu, Fanjun Cheng, Liling Zhang
Multiple myeloma stem cells (MMSCs) have been considered as the major cause resulting in relapse. Eradicating MMSCs may be an effective strategy to improve the outcome of multiple myeloma (MM). Increased activity of aldehyde dehydrogenase (ALDH) has been found in MMSCs, but whether inhibiting ALDH activity can eliminate MMSCs remains unknown. Disulfiram (DS) has been reported as an inhibitor of ALDH, and increasing studies showed it has anti-cancer effects in a copper (Cu)-dependent manner. In this study, we isolated ALDH+ cells of MM by Aldefluor assay and demonstrated they possessed tumorigenesis capacities in vitro and in vivo...
April 17, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29664675/knockout-of-glucose-transporter-glut6-has-minimal-effects-on-whole-body-metabolic-physiology-in-mice
#5
Frances L Byrne, Ellen M Olzomer, Robert Brink, Kyle L Hoehn
Glucose transporter 6 (GLUT6) is a member of the facilitative glucose transporter family. GLUT6 is up-regulated in several cancers, but is not widely expressed in normal tissues. Previous studies have shown that GLUT6 knockdown kills endometrial cancer cells that express elevated levels of the protein. However, whether GLUT6 represents a viable anti-cancer drug target is unclear because the role of GLUT6 in normal metabolic physiology is unknown. Herein we generated GLUT6 knockout mice to determine how loss of GLUT6 affected whole body glucose homeostasis and metabolic physiology...
April 17, 2018: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29663927/encapsulation-of-5-flurouracil-into-plga-nanofibers-and-enhanced-anticancer-effect-in-combination-with-ajwa-dates-extract-phoenix-dactylifera-l
#6
Fazal Khan, Musab Aldhahri, Mohammad Asif Hussain, Kalamegam Gauthaman, Adnan Memic, Adel Abuzenadah, Taha Kumosani, Elie Barbour, Nazeeh Shuja Alothmany, Rabah Wasil Aldhaheri
Side effects connected with chemotherapeutic agents used in cancer treatment has led to alternative modalities of combinatorial therapies in an attempt to reduce the drug dosage and associated risks. In the current study we evaluated the potential use of Ajwa Dates Extract (ADE), reported to have anti-cancer effects, as an adjuvant therapy in combination with 5-flurouracil (5FU) against the human-breast-adenocarcinoma cell line (MFC-7) in vitro. The effects of ADE alone and in combination with 5-FU were evaluated in terms of cell viability and cytotoxicity...
March 1, 2018: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/29663923/selenium-and-iron-oxide-nanocomposites-for-magnetically-targeted-anti-cancer-applications
#7
Halla Laufey Hauksdóttir, Thomas J Webster
Iron oxide nanoparticles (IONP) are already well-established in the medical field due to their ability to improve contrast in magnetic resonance imaging (MRI) and for their external magnetic control in the body. Moreover, selenium has been shown to kill numerous cancer cells at lower concentrations that IONP (e.g., 1 μg/ml). Selenium is a trace mineral of growing interest in cancer treatment since it is an essential nutrient in the human body and can interfere with thiolcontaining proteins necessary for cancer cells to function...
March 1, 2018: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/29663879/anti-cancer-effects-of-metformin-recent-evidences-for-its-role-in-prevention-and-treatment-of-cancer
#8
Masoumeh Kheirandish, Hamidreza Mahboobi, Maryam Yazdanparast, Warda Kamal, Mohammad A Kamal
Metformin is widely used for the management of type 2 diabetes mellitus (T2DM). Recently growing evidence has shown its anti-cancer effects. The results are mainly obtained from observational studies and thus, little information is available concerning the mechanisms of action. Adenosine monophosphate (AMP)-activated protein kinase (AMPK) plays an important role in the mechanism of action of metformin. The anti-cancer mechanisms of metformin include direct and indirect effects. The direct effects of metformin include AMPK-independent and AMPK-dependent effects, whereas the decrease in glucose level, hyperinsulinemia, and Insulin-like growth factor 1 (IGF-1) level was considered its indirect effects...
April 16, 2018: Current Drug Metabolism
https://www.readbyqxmd.com/read/29662863/investigation-of-bax-and-bcl2-expression-and-apoptosis-in-a-resveratrol-and-prednisolone-treated-human-t-all-cell-line-ccrf-cem
#9
Taghi Khanzadeh, Majid Farshdousti Hagh, Mehdi Talebi, Bahman Yousefi, Ako Azimi, Abbas Ali Hossein Pour Feizi, Behzad Baradaran
Background: The numerous side effects and chemo-resistance of conventional chemical drugs in the treatment of malignancies have led to consideration of the anti-cancer properties of natural products. In the present study, we aimed to explore the apoptotic effect of two natural components, resveratrol and prednisolone, on the T acute lymphoblastic leukemia (ALL) cell line, CCRF-CEM. Our findings suggested the incorporation of these natural agents into drug regimens to treat patients with ALL...
March 2018: Blood Research
https://www.readbyqxmd.com/read/29662645/a-novel-herbal-formula-sge-induces-endoplasmic-reticulum-stress-mediated-cancer-cell-death-and-alleviates-cachexia-symptoms-induced-by-colon-26-adenocarcinoma
#10
Aeyung Kim, Minju Im, Jin Yeul Ma
Cachexia in cancer patients, characterized by marked involuntary weight loss and impaired physical function, is associated with a poor prognosis in response to conventional treatment and with an increase in cancer-related mortality. Prevention of skeletal muscle loss under cancer-induced cachexia via inhibition of pro-cachectic factors, as well as a reduction in tumor mass, has been considered reasonable pharmacological and nutritional interventions to treat cancer patients. In this study, we constructed a novel herbal formula, SGE, which contains Ginseng Radix alba, Atractylodis Rhizoma alba , and Hoelen , examined its anti-cancer and anti-cachexia efficacies...
March 27, 2018: Oncotarget
https://www.readbyqxmd.com/read/29662195/ngr-asn-gly-arg-targeted-delivery-of-coagulase-to-tumor-vasculature-arrests-cancer-cell-growth
#11
Khaled Seidi, Rana Jahanban-Esfahlan, Hassan Monhemi, Peyman Zare, Babak Minofar, Amir Daei Farshchi Adli, Davoud Farajzadeh, Ramezan Behzadi, Mehran Mesgari Abbasi, Heidi A Neubauer, Richard Moriggl, Nosratollah Zarghami, Tahereh Javaheri
Induction of selective thrombosis and infarction in tumor-feeding vessels represents an attractive strategy to combat cancer. Here we took advantage of the unique coagulation properties of staphylocoagulase and genetically engineered it to generate a new fusion protein with novel anti-cancer properties. This novel bi-functional protein consists of truncated coagulase (tCoa) and an NGR (GNGRAHA) motif that recognizes CD13 and αv β3 integrin receptors, targeting it to tumor endothelial cells. Herein, we report that tCoa coupled by its C-terminus to an NGR sequence retained its normal binding activity with prothrombin and av β3 integrins, as confirmed in silico and in vitro...
April 17, 2018: Oncogene
https://www.readbyqxmd.com/read/29662019/liposomal-drug-delivery-systems-and-anticancer-drugs
#12
REVIEW
Temidayo O B Olusanya, Rita Rushdi Haj Ahmad, Daniel M Ibegbu, James R Smith, Amal Ali Elkordy
Cancer is a life-threatening disease contributing to ~3.4 million deaths worldwide. There are various causes of cancer, such as smoking, being overweight or obese, intake of processed meat, radiation, family history, stress, environmental factors, and chance. The first-line treatment of cancer is the surgical removal of solid tumours, radiation therapy, and chemotherapy. The systemic administration of the free drug is considered to be the main clinical failure of chemotherapy in cancer treatment, as limited drug concentration reaches the tumour site...
April 14, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29661544/renal-cell-carcinoma-for-the-nephrologist
#13
REVIEW
Mark A Perazella, Robert Dreicer, Mitchell H Rosner
Renal cell carcinoma (RCC), a malignancy whose incidence is increasing, is frequently encountered in general nephrology practice when acute and chronic kidney disease occurs in the course of disease. Importantly, when kidney disease develops in the setting of RCC, mortality is significantly increased with patients often dying of a non-cancer-related complication of kidney disease. As such, practicing nephrologists need to have a working knowledge of this cancer's biology, treatment, and complications. Nephrologists should be involved in all aspects of the care of patients with RCC including in the acute setting prior to nephrectomy and in the chronic setting for patients with post-nephrectomy chronic kidney disease and those receiving potentially nephrotoxic anti-cancer agents...
April 13, 2018: Kidney International
https://www.readbyqxmd.com/read/29661228/mir-760-suppresses-human-colorectal-cancer-growth-by-targeting-batf3-ap-1-cyclind1-signaling
#14
Ling Cao, Yulin Liu, Dan Wang, Lan Huang, Feng Li, Jinbo Liu, Chaoqi Zhang, Zhibo Shen, Qun Gao, Weitang Yuan, Yi Zhang
BACKGROUND: Recent studies have reported that microRNAs (miRNAs) often function as negative post-transcriptional regulators with altered expression levels found in colorectal cancer (CRC). There have been few studies on miRNAs that regulate the oncogenic alterations in CRC. Here, we aim to explore the anti-cancer miRNA and the potential mechanisms by which miRNAs modulate CRC progression. METHODS: We performed an integrated analysis of CRC miRNA expression datasets in The Cancer Genome Atlas (TCGA)...
April 16, 2018: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/29660518/hoxb4-knockdown-enhances-the-cytotoxic-effect-of-paclitaxel-and-cisplatin-by-downregulating-abc-transporters-in-ovarian-cancer-cells
#15
Ying Li, Jingli Sun, Shaofeng Gao, Heping Hu, Pengmu Xie
Therapeutic effects of anti-cancer drugs for ovarian cancer were limited due to the rapid development of chemotherapy resistance. The aim of this study was to test whether knockdown of Homeobox B4 (HOXB4) enhanced the cytotoxic effect of paclitaxel and cisplatin in ovarian cancer cells. HOXB4 expressions at mRNA and protein levels were upregulated in Taxol-resistant A2780 (A2780/Taxol) and DDP-resistant SKOV-3 (SKOV-3/DDP) cells. HOXB4 knockdown enhanced the cytotoxic effects of Taxol and DDP in A2780/Taxol and SKOV-3/DDP cells, respectively...
April 13, 2018: Gene
https://www.readbyqxmd.com/read/29660390/review-of-embryo-fetal-developmental-toxicity-studies-performed-for-pharmaceuticals-approved-by-fda-in-2016-and-2017
#16
REVIEW
Paul Barrow
Details of embryo-fetal development (EFD) studies were compiled for all FDA drug approvals in 2016-17. Rats and rabbits were used for 63% of small molecule (SM) drugs. The cynomolgus monkey was used for 47% of biopharmaceuticals. Rodent studies using the clinical mAb or animal homologue replaced monkey studies under some circumstances. EFD studies were not required for anti-cancer drugs when the mode of action was associated with known developmental risk. One quarter of SM non-oncology drugs and all tested SM anti-cancer drugs were teratogenic in at least one species...
April 13, 2018: Reproductive Toxicology
https://www.readbyqxmd.com/read/29660245/1-2-3-triazole-tagged-3h-pyrano-2-3-d-pyrimidine-6-carboxylate-derivatives-synthesis-invitro-anticancer-activity-molecular-docking-and-dna-interaction-studies
#17
Sathish Kumar Boda, Vasantha Pishka, P V Anantha Lakshmi, Srinivas Chinde, Paramjit Grover
A series of novel ethyl 2,7-dimethyl-4-oxo-3-((1-phenyl-1H-1,2,3-triazol-4-yl)methyl)-4,5-dihydro-3H-pyrano[2,3-d]pyrimidine-6-carboxylate derivatives 7(a-m) were efficiently synthesized employing click chemistry approach and evaluated for in vitro anti cancer activity against four tumor cell lines: A549 (human lung adenocarcenoma cell line), HepG2 (Human hematoma), MCF-7 (Human breast adenocarcinoma), and SKOV3 (human ovarian carcinoma cell line). Among the compounds tested, the compounds 7a, 7b, 7f, 7l and 7m have shown potential and selective activity against human lung adenocarcenoma cell line (A549) with IC50 ranging from 0...
April 16, 2018: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/29660159/cannabis-and-anti-cancer-drugs-societal-usage-and-expected-pharmacological-interactions-a-review
#18
REVIEW
Régis Bouquié, Guillaume Deslandes, Hélène Mazaré, Marion Cogné, Julien Mahé, Matthieu Grégoire, Pascale Jolliet
Cannabis is a plant that has been used for centuries to relieve a wide range of symptoms. Since the 1960s, interest in medical research into this plant has grown steadily. Already very popular for recreational use, a growing number of consumers not accustomed to using cannabis for psychoactive purposes, have begun to use it as an alternative or complement to mainstream pharmaceutical medicines. The principal unsubstantiated or "social" uses of cannabis are based mainly on data that is at best controversial, but usually not scientifically proven...
April 16, 2018: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/29659015/possible-repurposing-of-pyrvinium-pamoate-for-the-treatment-of-mesothelioma-a-pre-clinical-assessment
#19
Marcella Barbarino, Daniele Cesari, Riccardo Intruglio, Paola Indovina, Asadoor Namagerdi, Franca Maria Bertolino, Maria Bottaro, Delaram Rahamani, Cristiana Bellan, Antonio Giordano
Malignant mesothelioma (MM) is a very aggressive asbestos-related cancer, whose incidence is increasing worldwide. Unfortunately, no effective therapies are currently available and the prognosis is extremely poor. Recently, the anti-helminthic drug pyrvinium pamoate has attracted a strong interest for its anti-cancer activity, which has been demonstrated in many cancer models. Considering the previously established inhibitory effect of pyrvinium pamoate on the Wnt/β-catenin pathway and given the important role of this pathway in MM, we investigated the potential anti-tumor activity of this drug in MM cell lines...
April 16, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29658479/-the-zebrafish-model-in-oncology
#20
Pamela Völkel, Babara Dupret, Xuefen Le Bourhis, Pierre-Olivier Angrand
Although cell culture and mouse models will remain a cornerstone of cancer research, the unique capabilities of the zebrafish outline the potential of this model for shedding light on cancer biology in vivo. Zebrafish develops cancers spontaneously, after chemical mutagenesis or through genetic manipulations. Furthermore, zebrafish cancers are similar to human tumors at the histological and molecular levels allowing the study of tumor initiation, progression and heterogeneity. Xenotransplantation of human cancer cells in embryos or adult zebrafish presents the advantage of following cancer cell behavior in vivo...
April 2018: Médecine Sciences: M/S
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