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https://www.readbyqxmd.com/read/28634815/autoimmune-diabetes-induced-by-pd-1-inhibitor-retrospective-analysis-and-pathogenesis-a-case-report-and-literature-review
#1
Marie-Léa Gauci, Pauline Laly, Tiphaine Vidal-Trecan, Barouyr Baroudjian, Jérémy Gottlieb, Nika Madjlessi-Ezra, Laetitia Da Meda, Isabelle Madelaine-Chambrin, Martine Bagot, Nicole Basset-Seguin, Cécile Pages, Samia Mourah, Philippe Boudou, Céleste Lebbé, Jean-François Gautier
Anti-PD-1 antibody treatment is approved in advanced melanoma and provides median overall survival over 24 months. The main treatment-related side effects are immune-related adverse events, which include rash, pruritus, vitiligo, thyroiditis, diarrhoea, hepatitis and pneumonitis. We report a case of autoimmune diabetes related to nivolumab treatment. A 73-year-old man was treated in second line with nivolumab at 3 mg/kg every two weeks for metastatic melanoma. At 6 weeks of treatment, he displayed diabetic ketoacidosis...
June 20, 2017: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/28625707/-algorithms-based-on-medico-administrative-data-in-the-field-of-endocrine-nutritional-and-metabolic-diseases-especially-diabetes
#2
S Fosse-Edorh, A Rigou, S Morin, L Fezeu, L Mandereau-Bruno, A Fagot-Campagna
BACKGROUND: Medico-administrative databases represent a very interesting source of information in the field of endocrine, nutritional and metabolic diseases. The objective of this article is to describe the early works of the Redsiam working group in this field. METHODS: Algorithms developed in France in the field of diabetes, the treatment of dyslipidemia, precocious puberty, and bariatric surgery based on the National Inter-schema Information System on Health Insurance (SNIIRAM) data were identified and described...
June 15, 2017: Revue D'épidémiologie et de Santé Publique
https://www.readbyqxmd.com/read/28620573/clinical-characteristics-and-outcomes-of-patients-with-ischemic-and-non-ischemic-complete-heart-block
#3
Murtaza Sundhu, Mehmet Yildiz, Mubbasher Syed, Bhavan Shah, Sajjad Gul, Omer Afzal, Lon Castle
INTRODUCTION: Third degree or complete heart block (CHB) is a medical emergency and usually requires permanent pacemaker placement. CHB can be caused by cardiac ischemia or non-ischemic conditions such as infiltrative diseases or fibrosis. The purpose of this study is to identify the baseline clinical characteristics associated with ischemic versus non-ischemic causes of complete heart block and compare their outcomes. MATERIALS AND METHODS: An institutional review broad approval was granted by the Cleveland Clinic Health System...
May 12, 2017: Curēus
https://www.readbyqxmd.com/read/28615030/the-autoimmune-burden-in-juvenile-idiopathic-arthritis
#4
Elena Tronconi, Angela Miniaci, Andrea Pession
BACKGROUND: Juvenile idiopathic arthritis (JIA) is a chronic inflammatory arthritis of unknown origin which can be considered an autoimmune disease (AD). The aim of this study is to analyse the presence of two or more autoimmune diseases (polyautoimmunity) in patients suffering from JIA and to evaluate the occurrence of ADs in their families. METHODS: Seventy-nine patients diagnosed with JIA aged 0-21 years, admitted to the Paediatric Rheumatology Unit, Sant'Orsola-Malpighi Hospital, Bologna were screened for ADs...
June 14, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/28611636/autoimmune-diabetes-and-thyroiditis-complicating-treatment-with-nivolumab
#5
Li Li, Awais Masood, Shahla Bari, Sahzene Yavuz, Alan B Grosbach
Programmed cell death-1 (PD-1) ligand inhibitors have gained popularity in the treatment of advanced non-small-cell lung cancer. The immune system is regulated by stimulatory and inhibitory signaling and aims to achieve the balance between activation and inhibition. Treatment with immune checkpoint inhibitors enhances immune response, but is also known to diminish immune tolerance and increase autoimmune toxicity. Here we present a case of a patient with advanced squamous cell lung cancer who developed type I diabetes and thyroiditis after treatment with PD-1 checkpoint inhibitor nivolumab...
January 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/28607535/gender-disparity-in-the-relationship-between-prevalence-of-thyroid-nodules-and-metabolic-syndrome-components-the-shdc-cdpc-community-based-study
#6
Xiaoying Ding, Ying Xu, Yufan Wang, Xiaohua Li, Chunhua Lu, Jing Su, Yuting Chen, Yuhang Ma, Yanhua Yin, Yong Wu, Yaqiong Jin, Lihua Yu, Junyi Jiang, Naisi Zhao, Qingwu Yan, Andrew S Greenberg, Haiyan Sun, Mingyu Gu, Li Zhao, Yunhong Huang, Yijie Wu, Chunxian Qian, Yongde Peng
The study is aimed to investigate the pathogenesis underlying the increased prevalence of thyroid nodule (TN) in different levels of metabolic syndrome (MetS) components and analyze the relationships between TN and MetS components. A total of 6,798 subjects, including 2201 patients with TN, were enrolled in this study. Anthropometric, biochemical, thyroid ultrasonographic, and other metabolic parameters were all measured. There was obviously sexual difference in the prevalence of TN (males 26.0%, females 38...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28603603/multi-modality-surgical-treatment-for-an-increasingly-common-patient-with-morbid-obesity-and-papillary-thyroid-carcinoma
#7
Zachary A Ichter, Madhumithaa Parthasarathy, John M Morton
The link between obesity and health disorders such as hypertension, diabetes and coronary artery disease is well known. When a morbidly obese patient presents with a new diagnosis of any cancer, it adds to the many challenges both the patient and treating physicians face. Not only is surgical resection of the malignancy more technically challenging, but also postoperative care such as therapeutic radiation and follow-up imaging is limited by the weight and size restrictions of the machines. With time to treatment being a key factor in limiting the progression of disease, standard weight loss techniques such as diet and exercise in the majority of cases take too long or fail to lead to adequate results...
June 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/28584858/a-longitudinal-population-study-of-the-impact-of-cataract-extraction-on-sleep-quality
#8
Yanjun Chen, David M Nondahl, Carla R Schubert, Dayna S Dalton, Adam J Paulsen, Barbara E K Klein, Ronald Klein, Karen J Cruickshanks
PURPOSE: To investigate the longitudinal effects of cataract extraction on sleep quality in two discrete population cohorts. METHODS: 301 participants who had senile cataract in both eyes at the baseline examination were selected from two large longitudinal epidemiologic studies of age-related eye disease, hearing, olfaction, and cognition. The participants were divided into two groups: one had cataract surgery (CS) in both eyes, and the other had no cataract surgery (NCS) in either eye by the follow up examination...
2017: Cogent Medicine
https://www.readbyqxmd.com/read/28583704/thyroid-disease-and-type-1-diabetes-in-dutch-children-a-nationwide-study-young-dudes-3
#9
Engelina Spaans, Eelco Schroor, Klaas Groenier, Henk Bilo, Nanne Kleefstra, Paul Brand
OBJECTIVE: To investigate the prevalence of overt thyroid disease in children in The Netherlands with and without type 1 diabetes mellitus (T1DM). STUDY DESIGN: Nationwide, retrospective cohort study in The Netherlands. Using the national registry of both healthcare reimbursement and pharmaceutical care, data of all Dutch children (aged 0-14 years) with a diagnosis of T1DM, or a diagnosis of hypothyroidism or hyperthyroidism in the period 2009-2011. RESULTS: The prevalence of thyroid disease was 0...
June 2, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28578598/hyperthyroidism-hypothyroidism-and-cause-specific-mortality-in-a-large-cohort-of-women
#10
Neige My Journy, Marie-Odile Bernier, Michele M Doody, Bruce H Alexander, Martha Linet, Cari Meinhold Kitahara
BACKGROUND: The prevalence of hyperthyroidism and hypothyroidism is 0.5-4% in iodine-replete communities, but 5-10 times higher in women than men. Those conditions are associated with a broad range of metabolic disorders and cardiovascular diseases. Biological evidence of a role of thyroid hormones in carcinogenesis also exists. However, the association between thyroid dysfunction and cardiovascular disease or cancer mortality risk remains controversial. In a large cohort of women, we evaluated the associations of hyperthyroidism and hypothyroidism with cause-specific mortality after nearly 30 years of follow-up...
June 3, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28578377/association-of-thyroid-stimulating-hormone-levels-with-microvascular-complications-in-type-2-diabetes-patients
#11
Qi Qi, Qiu-Mei Zhang, Chun-Jun Li, Rong-Na Dong, Jin-Jin Li, Jian-Ying Shi, De-Min Yu, Jing-Yun Zhang
BACKGROUND Subclinical hypothyroidism (SCH) is typically featured by elevated serum concentration of thyroid-stimulating hormone (TSH). This study aimed to determine the relationship between TSH levels and microvascular complications in type 2 diabetes patients. MATERIAL AND METHODS A total of 860 type 2 diabetes patients were enrolled in this cross-sectional study. Subjects were evaluated for anthropometric measurements, thyroid function, diabetic retinopathy, and diabetic kidney disease. TSH was divided into 3 levels: 0...
June 4, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28578306/multiple-recurrent-ischaemic-strokes-in-a-patient-with-cancer-is-there-a-role-for-the-initiation-of-anticoagulation-therapy-for-secondary-stroke-prevention
#12
Giselle Alexandra Suero-Abreu, Jia Zhen Cheng, Ryna Karina Then
A 52-year-old woman with a medical history of cervical and thyroid cancer, hypertension, dyslipidaemia, uncontrolled diabetes and heavy smoking was diagnosed with a new metastatic cholangiocarcinoma. While undergoing palliative chemotherapy, she developed dysarthria and left-sided weakness. Imaging studies showed multiple bilateral ischaemic strokes. On hospital days 2 and 5, she developed worsening neurological symptoms and imaging studies revealed new areas of ischaemia on respective days. Subsequent workup did not revealed a clear aetiology for the multiple ischaemic events and hypercoagulability studies were only significant for a mildly elevated serum D-dimer level...
June 3, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28574011/coexistence-of-celiac-disease-type-1-diabetes-mellitus-in-children
#13
Preeti Singh, Anju Seth, Praveen Kumar, Sushma Sajjan
BACKGROUND & OBJECTIVES: Type 1 diabetes mellitus (T1DM) and celiac disease (CD) tend to co-exist due to similar underlying genetic predisposition. Failure to recognize CD in patients with T1DM predisposes them to complications. The present study was aimed to assess children with T1DM for the presence of CD. METHODS: This was a retrospective analysis of the records of children with T1DM attending paediatric endocrinology clinic at a tertiary care hospital in north India from January 2006 to May 2014...
January 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28571126/study-of-glycated-haemoglobin-hba1c-in-non-diabetic-subjects-with-subclinical-hypothyroidism
#14
Mayur Goradhanbhai Makadia, Vishwal Indravadan Patel, Kinjal Prahaladbhai Patel, Aashna Darshanbhai Shah, Kaushik Salubhai Chaudhari, Hitesh Natvarbhai Shah, Haridas Neelakandan Nilayangode
INTRODUCTION: India has the higher prevalence of prediabetes, diabetes and hypothyroidism. Subclinical Hypothyroidism (SH) is more prevalent in the females than in the males. Studies have shown the elevated HbA1c in the non-diabetic hypothyroid patients. SH is defined by normal serum triiodothyronine (T3), thyroxine (T4) levels and serum Thyroid Stimulating Hormone (TSH) level falling between 4.2 to 10 mU/L. AIM: To study the HbA1c level in the non-diabetic SH patients and to compare the HbA1c level with the controls...
April 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28570329/endocrine-emergencies-with-neurologic-manifestations
#15
Makoto Ishii
PURPOSE OF REVIEW: This article provides an overview of endocrine emergencies with potentially devastating neurologic manifestations that may be fatal if left untreated. Pituitary apoplexy, adrenal crisis, myxedema coma, thyroid storm, acute hypercalcemia and hypocalcemia, hyperglycemic emergencies (diabetic ketoacidosis and hyperglycemic hyperosmolar state), and acute hypoglycemia are discussed, with an emphasis on identifying the signs and symptoms as well as diagnosing and managing these clinical entities...
June 2017: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/28559720/magnitude-of-diabetes-and-hypertension-among-patients-with-dry-eye-syndrome-at-a-tertiary-hospital-of-riyadh-saudi-arabia-a-case-series
#16
Abdullah Omar Al Houssien, Rana Omar Al Houssien, Abdulaziz Al-Hawass
PURPOSE: To study the magnitude of chronic diseases among patients suffering from Dry Eye Syndrome (DES) and compare them with published findings in the literature. METHODS: Patients diagnosed in 2016 suffering from DES based on presenting symptoms and findings of ocular examination were included in this study. The demographic information included age and gender. Chronic diseases among them were identified through case records, assessment and ongoing medications...
April 2017: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/28556290/moderate-to-high-normal-levels-of-thyrotropin-is-a-risk-factor-for-urinary-incontinence-and-an-unsuitable-quality-of-life-in-women-over-65-years
#17
Estela Cuevas-Romero, Angélica Sánchez-Cardiel, Angélica M Zamora-Gallegos, Rosalía Cruz-Lumbreras, Dora L Quintanilla, Francisco Castelán, Margarita Martínez-Gómez
The present study was aimed to investigate the relationship between normal serum concentrations of thyrotropin (TSH) and urinary incontinence (IU), urinary infections, and quality of life in old women. Euthyroid post-menopausal women without sarcopenia, estrogen replacement, emotional illness, and-or cancer were enrolled as participants. Anthropometric indicators, serum glucose and estradiol, and thyroid profile were measured. Sociodemographic, clinical, physical activity, and quality of life (SF-36) surveys were applied...
May 28, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/28551907/-the-clinical-approach-to-diagnosis-and-treatment-of-hypothyroidism
#18
REVIEW
Amir Bashkin, Marina Nodelman
Hypothyroidism is the most frequent endocrinologic disorder after diabetes. It is caused by the insufficient production of thyroid hormones Thyroxine (T4) and Triiodothyronine (T3). T4 is the main hormone that is accumulated in the thyroid gland, while T3 is the active hormone that is produced from T4 in the peripheral tissues. More than 99% of the patients have primary hypothyroidism which is due to thyroid disorder mainly Hashimoto's thyroiditis or iatrogenic. Hypothyroidism is divided into sub-clinical when T4 is in the normal range and overt when it is low and usually the TSH level is higher than 10 mIU\L...
May 2017: Harefuah
https://www.readbyqxmd.com/read/28545910/thyroid-function-test-in-diabetic-ketoacidosis
#19
Amir Ahmad Mirboluk, Farzaneh Rohani, Ramin Asadi, Mohammad Reza Eslamian
BACKGROUND: Metabolism of thyroid hormones is influenced by acute systemic illnesses including diabetic ketoacidosis. In these cases T3 level is usually decreased and this condition is called "low T3 syndrome" which is usually reversed by treating the under lying Disease. OBJECTIVES: thyroid function test analysis before and after diabetic ketoacidosis treatment. METHOD: In this cross sectional study thyroid function tests were analyzed in 16 diabetic ketoacidosis patients according to American diabetic association before and after insulin therapy...
April 15, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28542464/maternal-low-thyroxin-levels-are-associated-with-adverse-pregnancy-outcomes-in-a-chinese-population
#20
Yong Zhang, Xiaobei Dai, Shuai Yang, Chen Zhang, Mi Han, He-Feng Huang, Jianxia Fan
Although thyroid dysfunction in early pregnancy may have adverse effects on pregnancy outcomes, few studies have examined the relationship between maternal low free thyroxin (FT4) levels in both first and third trimesters of pregnancy and the incidence of adverse pregnancy outcomes. We hypothesized that low FT4 levels in either first or third trimesters of pregnancy may have different effects on pregnancy outcomes. The study included 6,031 mothers who provided both first and third pregnancy serum samples for analyses of thyroid function...
2017: PloS One
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