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Topical anesthetic

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https://www.readbyqxmd.com/read/29160002/a-randomized-double-blind-trial-of-needle-free-injected-lidocaine-versus-topical-anesthesia-for-infant-lumbar-puncture
#1
Ryan Caltagirone, Vidya R Raghavan, Kathleen Adelgais, Genie E Roosevelt
OBJECTIVES: Lumbar punctures (LPs) are commonly performed in febrile infants to evaluate for meningitis, and local anesthesia increases the likelihood of LP success. Traditional methods of local anesthesia require injection which may be painful or topical application which is not effective immediately. Recent advances in needle-free jet injection may offer a rapid alternative to these modalities. We compared a needle-free jet-injection system (J-Tip(™) ) with 1% buffered lidocaine to topical anesthetic (TA) cream for local anesthesia in infant LPs...
November 20, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/29159751/septal-and-turbinate-surgery-is-overnight-essential
#2
Ana Sousa Menezes, Joana R Guimarães, Miguel Breda, Vicente Vieira, Luís Dias
INTRODUCTION: The performance of septoplasty and turbinate surgery in an outpatient basis is an increasingly established practice, although is still a controversial topic. METHODS: Retrospective analysis of 227 patients who underwent septoplasty ± inferior and/or middle turbinoplasty. Demographic, clinical, surgical, and anesthetic data were collected. Our primary outcomes were rates of perioperative complications, prolongation of hospital stay (PHS), unexpected hospital revisits (UHR), or readmissions within 30 days of surgery...
November 20, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29153919/patient-and-health-care-provider-responses-from-a-prospective-double-blind-randomized-controlled-trial-comparing-vapocoolant-spray-versus-placebo-spray-in-adults-undergoing-venipuncture-in-the-emergency-department
#3
Tracy Barbour, Sharon O'Keefe, Sharon E Mace
Painful medical procedures are common. Topical anesthetics are easily applied, rapid onset, inexpensive, and avoid injection pain and needlestick injury. The aims of this study, using patient and health care provider questionnaires, were to answer the following questions: (1) Does vapocoolant spray decrease venipuncture pain? (2) Would patients be satisfied with and use a vapocoolant spray in the future? (3) Would providers be satisfied with and use a vapocoolant spray in the future? Adults (18-80 years) in a hospital emergency department (ED) were randomly assigned to sterile water placebo spray (S) (N = 50) or vapocoolant spray (V) (N = 50) before venipuncture...
November 16, 2017: Pain Management Nursing: Official Journal of the American Society of Pain Management Nurses
https://www.readbyqxmd.com/read/29153297/pain-management-practice-and-guidelines-in-jordanian-pediatric-intensive-care-units
#4
Ahmad Ismail, Paula Forgeron, Viola Polomeno, Huda Gharaibeh, Denise Harrison
Limited knowledge exists of current pain management practices and supporting guidelines in Jordanian pediatric intensive care units. To determine the current pain management practices and the availability and content of practice guidelines in Jordanian pediatric intensive care units, we conducted a cross-sectional and multisite survey of four pediatric intensive care units in Jordan. A questionnaire was developed and orally administered over the phone or in person to head nurses or their nominees to capture pain management practices and the existence and content of guidelines...
November 15, 2017: Pain Management Nursing: Official Journal of the American Society of Pain Management Nurses
https://www.readbyqxmd.com/read/29152749/effect-of-topical-nasal-anesthetic-on-swallowing-in-healthy-adults-a-double-blind-high-resolution-manometry-study
#5
Esther Guiu Hernandez, Kristin Gozdzikowska, Olivia Apperley, Maggie-Lee Huckabee
OBJECTIVE: Topical nasal anesthetic (TNA) is used when evaluating pharyngeal swallowing with high-resolution manometry (HRM). It is unclear if desensitizing the nasal mucosa improves procedure tolerability or affects pharyngeal pressure. This study evaluated the effects of TNA on comfort and pharyngeal pressure using HRM. METHODS: A double-blinded study was conducted with 20 healthy participants ( x¯ = 27 years). Participants performed five saliva and five 10-mL swallows during two exams with ManoScan HRM ESO catheter (Medtronic, Minneapolis, MN) randomized under placebo (nonanesthetic lubricant) and anesthetized (0...
November 20, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29138115/active-forms-of-akt-and-erk-are-dominant-in-the-cerebral-cortex-of-newborn-pigs-that-are-unaffected-by-asphyxia
#6
Viktória Kovács, Valéria Tóth-Szűki, János Németh, Viktória Varga, Gábor Remzső, Ferenc Domoki
AIMS: Perinatal asphyxia (PA) often results in hypoxic-ischemic encephalopathy (HIE) in term neonates. Introduction of therapeutic hypothermia improved HIE outcome, but further neuroprotective therapies are still warranted. The present study sought to determine the feasibility of the activation of the cytoprotective PI-3-K/Akt and the MAPK/ERK signaling pathways in the subacute phase of HIE development in a translational newborn pig PA/HIE model. MAIN METHODS: Phosphorylated and total levels of Akt and ERK were determined by Western blotting in brain samples obtained from untreated naive, time control, and PA/HIE animals at 24-48h survival (n=3-3-6,respectively)...
November 11, 2017: Life Sciences
https://www.readbyqxmd.com/read/29135709/pilot-study-comparing-topical-anesthetic-agents-in-pterygium-surgery-subconjunctival-injection-versus-2-lidocaine-gel-versus-5-lidocaine-gel
#7
Felipe Pereira, Hélio Francisco Shiroma, Muller Gonçalves Urias, Verônica Haysa Yamada, Acácio Alves de Souza Lima, Ana Luisa Hofling-Lima, Michel Eid Farah, Eduardo Buchele Rodrigues
PURPOSE: To compare the efficacy of different concentrations of topical lidocaine gel with standard subconjunctival anesthesia. METHODS: This was a prospective randomized controlled pilot study with 3 different groups. Group SC received subconjunctival lidocaine and proparacaine drops as needed during surgery. Group L2 received 2% lidocaine gel and group L5 received 5% lidocaine gel. Both lidocaine gel groups could receive another gel dose as needed during the procedure...
November 13, 2017: Cornea
https://www.readbyqxmd.com/read/29107354/effects-of-extracorporeal-shock-wave-mediated-transdermal-local-anesthetic-drug-delivery-on-rat-caudal-nerves
#8
Jer-Junn Luh, Wan-Ting Huang, Kwan-Hwa Lin, Yi-You Huang, Po-Ling Kuo, Wen-Shiang Chen
Cavitation plays a substantial role in the clinical effects of extracorporeal shock wave therapy (ESWT). It is also generally accepted as a major mechanism in sonophoresis. To identify the enhancing effect of extracorporeal shock wave-mediated transdermal drug delivery, 24 Wistar rats were randomly assigned to four groups: (i) topical application of a eutectic mixture of local anesthetics (EMLA); (ii) 1-MHz ultrasound; (iii) ESWT pre-treatment combined with EMLA application; (iv) ESWT concurrent with EMLA application on rat tails...
October 27, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29095180/a-randomized-double-blind-trial-to-determine-if-vapocoolant-in-the-adult-population-improves-patient-perception-of-pain-with-peripheral-intravascular-access
#9
Courtney Edwards, Christina Noah
The purpose of this study was to investigate whether the use of a topical anesthetic spray (vapocoolant) at the site of intravenous access reduces pain and anxiety associated with peripheral intravenous (PIV) catheter insertion in an adult emergency department population. A randomized, double-blind, placebo-controlled, single-center trial, conducted from July to August, in an adult emergency department where 72 patients with orders for PIV insertion receiving either topical vapocoolant spray (n = 38) or placebo spray (n = 34)...
October 2017: Advanced Emergency Nursing Journal
https://www.readbyqxmd.com/read/29075099/design-and-evaluation-of-lidocaine-and-prilocaine-coloaded-nanoparticulate-drug-delivery-systems-for-topical-anesthetic-analgesic-therapy-a-comparison-between-solid-lipid-nanoparticles-and-nanostructured-lipid-carriers
#10
Peijun You, Ran Yuan, Chuanyu Chen
PURPOSE: Topical anesthesia analgesic therapy has diverse applicability in solving the barrier properties of skin and unfavorable physicochemical properties of drugs. Lidocaine (LID) combined with prilocaine (PRI) has been used as a topical preparation for dermal anesthesia for treatment of conditions such as paresthesia. MATERIALS AND METHODS: In this study, for combination anesthesia and overcoming the drawbacks of LID and PRI, respectively, LID- and PRI-loaded solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) were prepared and characterized by determination of their particle size, drug loading capacity, stability, in vitro drug release behavior and in vitro cellular viability...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29069016/topical-cryoanesthesia-for-the-relief-of-pain-caused-by-steroid-injections-used-to-treat-hypertrophic-scars-and-keloids
#11
RANDOMIZED CONTROLLED TRIAL
Xiuxia Wang, Xiaoli Wu, Ke Liu, Lingling Xia, Xunxun Lin, Wei Liu, Zhen Gao
Intralesional steroid injections are the standard treatment for hypertrophic scars and keloids. The procedure is, however, quite painful and is unpopular with patients because of this. Topical application of anesthetic creams, such as Ametop gel (tetracaine) and EMLA cream (lidocaine and prilocaine), has limited efficacy because of poor drug penetration. The onset of the analgesic effect is also slow, which means that the use of topical anesthetics is time-consuming in clinical practice.We hypothesized that a commercially available cryotip could be used to provide fast-acting topical cryoanesthesia that would reduce the pain associated with steroid injections...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29067087/effectiveness-of-interventions-for-pain-relief-in-hysterosalpingographyanetwork-meta-analysis-and-systematic-review
#12
REVIEW
Xin Guo, Zongjian Tan
OBJECTIVE: We aimed to evaluate the effectiveness of placebo, oral opioid analgesic (OOA), intravenous opioid analgesic (IOA), non-opioid analgesic (NOA), topical anesthetic (TA) and locally injected anesthetic (LIA) for pain relief duringhysterosalpingography (HSG) using a Bayesian network meta-analysis of data from randomized controlled trials. METHODS: PUBMED, EMBASE, and CENTRAL search engines were used to search and identify clinical trials that evaluated interventions for pain relief in HSG...
July 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29054280/topical-anesthetics-may-result-in-more-pain-and-need-for-rescue-anesthetics-than-infiltrative-anesthetics-in-patients-undergoing-scaling-and-root-planing
#13
Romina Brignardello-Petersen
No abstract text is available yet for this article.
October 14, 2017: Journal of the American Dental Association
https://www.readbyqxmd.com/read/29049297/functional-connectivity-structure-of-cortical-calcium-dynamics-in-anesthetized-and-awake-mice
#14
Patrick W Wright, Lindsey M Brier, Adam Q Bauer, Grant A Baxter, Andrew W Kraft, Matthew D Reisman, Annie R Bice, Abraham Z Snyder, Jin-Moo Lee, Joseph P Culver
The interplay between hemodynamic-based markers of cortical activity (e.g. fMRI and optical intrinsic signal imaging), which are an indirect and relatively slow report of neural activity, and underlying synaptic electrical and metabolic activity through neurovascular coupling is a topic of ongoing research and debate. As application of resting state functional connectivity measures is extended further into topics such as brain development, aging and disease, the importance of understanding the fundamental physiological basis for functional connectivity will grow...
2017: PloS One
https://www.readbyqxmd.com/read/29031658/randomized-controlled-pilot-study-of-the-preoperative-use-of-brimonidine-0-33-topical-gel-for-hemostasis-in-mohs-micrographic-surgery
#15
Edward Chen, Raj Ajay Patel, Young Jin Kwak, Conway C Huang
BACKGROUND: Brimonidine topical gel may be useful in cutaneous surgical procedures because of its vasoconstricting properties. OBJECTIVE: Assess the hemostatic effect of topically applied brimonidine in patients being treated with anticoagulants and undergoing Mohs micrographic surgery (MMS). METHODS: Subjects undergoing MMS were randomly assigned to the control (n = 10) or study arm (n = 14). Controls received standard-of-care MMS, whereas the study arm received the same and preoperative application of brimonidine...
December 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29028436/pain-management-after-hip-arthroscopy-systematic-review-of-randomized-controlled-trials-and-cohort-studies
#16
Jason J Shin, Chris L McCrum, Craig S Mauro, Dharmesh Vyas
BACKGROUND: Hip arthroscopy is often associated with significant postoperative pain and opioid-associated side effects. Effective pain management after hip arthroscopy improves patient recovery and satisfaction and decreases opioid-related complications. PURPOSE: To collect, examine, and provide a comprehensive review of the available evidence from randomized controlled trials and comparative studies on pain control after hip arthroscopy. STUDY DESIGN: Systematic review...
October 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29017289/comparative-evaluation-of-the-efficacy-of-lignocaine-containing-topical-anesthetic-agents-during-extraction-of-deciduous-anterior-teeth
#17
Mythri Sarpangala, Ashwin Devasya, Ashford L George
To evaluate the efficacy of 2%, 4% Lignocaine, EMLA mixture and Precaine topical anaesthetic agents (with 1:1, 00,000 epinephrine) during the extraction of deciduous anterior tooth. Eighty patients with pre-shedding mobility of deciduous anterior tooth were divided randomly into four groups. Lignocaine, in amount of 2% and 4%, Precaine and EMLA topical anaesthetic agents were applied and the tooth was extracted. VAS has been used to assess the subjective pain while Wong-Baker faces scale and SEM pain scale have been used to record the objective pain to check the efficacy of these topical anaesthetic agents...
October 9, 2017: Minerva Stomatologica
https://www.readbyqxmd.com/read/28979320/the-effect-of-silver-nanoparticles-on-wounds-contaminated-with-pseudomonas-aeruginosa-in-mice-an-experimental-study
#18
Malahat Ahmadi, Masood Adibhesami
The microorganisms have been usually noted as the major cause of delayed wound healing. Pseudomonas aeruginosa is the most common pathogen causing these infections. Silver nanoparticles (AgNPs) show ample antibacterial activities. In present study, the effect of AgNPs alone and in combination with tetracycline investigated on inoculated wounds with Pseudomonas aeruginosa in mice. Twenty mice anesthetized and full-thickness skin wounds created on back of them and the bacterial suspension added to each wound bed...
2017: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/28974451/combining-amino-amide-salts-in-mucoadhesive-films-enhances-needle-free-buccal-anesthesia-in-adults
#19
Renê Oliveira do Couto, Camila Cubayachi, Paulo Linares Calefi, Renata Fonseca Vianna Lopez, Vinícius Pedrazzi, Cristiane Masetto De Gaitani, Osvaldo de Freitas
Needle-phobia is usually a great concern in dentistry, and the replacement of painful injections by patient-friendly needle-free topical formulations would bring several advantages in dental practice worldwide. In this pursuit, the effects of combining prilocaine hydrochloride (PCL) and lidocaine hydrochloride (LCL) in different proportions in mucoadhesive films on their in vitro permeation and retention through porcine esophageal mucosa was studied. Complementarily, the permeation and retention of isolated LCL was investigated...
September 30, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28973329/the-ability-of-nitric-oxide-to-lower-intraocular-pressure-is-dependent-on-guanylyl-cyclase
#20
Stefan Muenster, Wolfgang S Lieb, Gregor Fabry, Kaitlin N Allen, Shivani S Kamat, Ann H Guy, Ana C Dordea, Leandro Teixeira, Robert E Tainsh, Binglan Yu, Wei Zhu, Nicole E Ashpole, Rajeev Malhotra, Peter Brouckaert, Donald B Bloch, Marielle Scherrer-Crosbie, W Daniel Stamer, Markus H Kuehn, Louis R Pasquale, Emmanuel S Buys
Purpose: While nitric oxide (NO) donors are emerging as treatments for glaucoma, the mechanism by which NO lowers intraocular pressure (IOP) is unclear. NO activates the enzyme guanylyl cyclase (GC) to produce cyclic guanosine monophosphate. We studied the ocular effects of inhaled and topically applied NO gas in mice and lambs, respectively. Methods: IOP and aqueous humor (AqH) outflow were measured in WT and GC-1α subunit null (GC-1-/-) mice. Mice breathed 40 parts per million (ppm) NO in O2 or control gas (N2/O2)...
September 1, 2017: Investigative Ophthalmology & Visual Science
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