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Topical anesthetic

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https://www.readbyqxmd.com/read/28719485/does-the-application-of-heat-gel-pack-after-eutectic-mixture-of-local-anesthetic-cream-improve-venipuncture-or-intravenous-cannulation-success-rate-in-children-a-randomized-control-trial
#1
Silvana Schreiber, Giorgio Cozzi, Giuseppa Patti, Andrea Taddio, Marcella Montico, Chiara Pierobon, Egidio Barbi
OBJECTIVE: Needle-related procedures are the most common sources of pain for children in the hospital setting. The most used topical anesthetic, eutectic mixture of local anesthetic (EMLA) cream, may cause transient vasoconstriction. It has been postulated that this vasoconstriction may decrease vein visualization. The application of heat gel pack after removal of EMLA cream in the site of venipuncture counteracts the vasoconstriction, improving vein visualization. We assessed using a prospective randomized controlled trial whether the application of heat gel pack increases the needle procedure success rate...
July 17, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28719234/the-in-vivo-effects-of-the-cb1-positive-allosteric-modulator-gat229-on-intraocular-pressure-in-ocular-normotensive-and-hypertensive-mice
#2
Elizabeth A Cairns, Anna-Maria Szczesniak, Alex J Straiker, Pushkar M Kulkarni, Roger G Pertwee, Ganesh A Thakur, William H Baldridge, Melanie E M Kelly
PURPOSE: Orthosteric cannabinoid receptor 1 (CB1) activation leads to decreases in intraocular pressure (IOP). However, use of orthosteric CB1 agonists chronically has several disadvantages, limiting their usefulness as clinically relevant drugs. Allosteric modulators interact with topographically distinct sites to orthosteric ligands and may be useful to circumvent some of these disadvantages. The purpose of this study was to investigate the effects of the novel CB1-positive allosteric modulator (PAM) GAT229 on IOP...
July 18, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28717616/topical-polidocanol-application-in-combination-with-static-stretching-in-tendinopathies-a-prospective-pilot-study
#3
Matthias Gatz, Simone Schrading, Timm Dirrichs, Marcel Betsch, Markus Tingart, Björn Rath, Christiane Kuhl, Valentin Quack
BACKGROUND: Highly operator-based injection therapy with vasosclerosing and anesthetic polidocanol is used for tendinopathies. This pilot-study evaluates the topical application of polidocanol gel. METHODS: Prospective case series. 39 patients with tendinopathies (14 Achilles, 14 patella, 11 wrist extensors) with a symptom duration > 6 months were included. Polidocanol and static stretching were the therapy in the first 2 weeks, while static stretching was continuously performed for 6 months...
January 2017: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/28716738/photodynamic-therapy-and-pain-a-systematic-review
#4
Jennifer Maria Ang, Irbaz Bin Riaz, Muhammad Umar Kamal, Gyorgy Paragh, Nathalie C Zeitouni
Photodynamic therapy (PDT) is an effective treatment for actinic keratoses and early skin cancers, and the only office procedure to control field cancerization. Procedure-associated pain limits widespread PDT use and by early termination of treatment can decrease overall therapeutic efficacy. Here we review and assess reported interventions on PDT-associated pain, in order to identify the most promising methods to manage treatment-associated pain and identify focus for future studies. Literature search was performed using MEDLINE, EMBASE, and the Cochrane Library by two independent reviewers to select publications that assessed and compared pain quantitatively during PDT treatment for actinic keratoses, basal cell carcinomas, and/or in situ squamous cell carcinomas...
July 14, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28712478/comparison-of-effects-of-local-anesthesia-and-two-point-acupressure-on-the-severity-of-venipuncture-pain-among-hospitalized-6-12-year-old-children
#5
Parisa Shahmohammadi Pour, Golnaz Foroogh Ameri, Majid Kazemi, Yones Jahani
The aim of the present study was to compare the effects of topical anesthesia and acupressure at the Yintang (Extra 1) and the Laogong (P-8) points on the severity of venipuncture pain among hospitalized 6-12-year-old children. A sample (n = 120) of 6-12-year-old hospitalized children was recruited from two teaching hospitals located in Rafsanjan, Iran. The children were allocated to the topical anesthesia, acupressure, and control groups. For children in the topical anesthesia and the acupressure groups, eutectic mixture of local anesthetic (EMLA) cream and two-point acupressure were used, respectively, prior to performing venipuncture, whereas children in the control group only received routine prevenipuncture care...
June 2017: Journal of Acupuncture and Meridian Studies
https://www.readbyqxmd.com/read/28691540/endoscopic-management-of-foreign-bodies-in-the-upper-gastrointestinal-tract-a-retrospective-study-of-1294-cases
#6
Chong Geng, Xiao Li, Rong Luo, Lin Cai, Xuelian Lei, Chunhui Wang
OBJECTIVE: To report our endoscopic outcomes and explore the effects of duration of impaction and anesthetic methods on the endoscopic removal of foreign bodies in the upper gastrointestinal tract. METHODS: All consecutive patients with suspected foreign body (FB) ingestion between January 2013 and June 2016 were enrolled. Demographic, clinical and endoscopic data were collected and analyzed. RESULTS: A total of 1294 patients aged seven months to 94 years were enrolled...
July 10, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28688643/topical-anesthesia-for-staple-removal-from-surgical-wounds-on-the-knee-a-prospective-double-blind-randomized-trial
#7
Tzu-Hao Tseng, Ching-Chuan Jiang, Shau-Huai Fu, Tsung-Lin Lee, Ya-Hui Chuang, Hongsen Chiang
BACKGROUND: Staple removal from surgical wounds is painful. Only a few articles have provided expert opinions using anesthetic cream for such a problem; however, direct application of the anesthetic cream to a wound may cause infection. A safe alternative can be an anesthetic patch without wound contact. MATERIALS AND METHODS: This was a prospective, double-blind, randomized clinical trial. Sixty patients who underwent primary total knee replacement were assigned to an experimental group or control group...
July 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28686756/local-anesthetics-in-cosmetic-dermatology
#8
Peter W Hashim, John K Nia, Mark Taliercio, Gary Goldenberg
Local anesthetics play an important role in cosmetic dermatology. Techniques using topical and regional anesthesia provide numerous pain management options for laser and injection treatments. In this article, we review strategies to maximize patient comfort during cosmetic interventions.
June 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/28682114/effectiveness-of-topical-application-of-ostrich-oil-on-the-healing-of-staphylococcus-aureus-and-pseudomonas-aeruginosa-infected-wounds
#9
Mohammad Reza Farahpour, Mahsa Vahid, Ahmad Oryan
BACKGROUND/AIMS: Management of infected wounds is one of the major challenges that surgeons and nurses face. Several antimicrobial agents have been used, but the toxicity, drug resistance and their effect on the healing process remain a matter of concern. The present study was designed to analyze the accelerative impact of topical application of Ostrich oil on infected wounds in a mouse model. MATERIALS AND METHODS: 72 BALB/c mice were divided into 4 main groups of control-sham, mupirocin and two treatment groups receiving 2% and 4% (V/W) concentrations of Ostrich oil, topically...
July 6, 2017: Connective Tissue Research
https://www.readbyqxmd.com/read/28680703/patient-pain-during-intravitreal-injections-under-topical-anesthesia-a-systematic-review
#10
Helio Francisco Shiroma, Augusto Key Karazawa Takaschima, Michel Eid Farah, Ana Luisa Höfling-Lima, Graziela de Luca Canto, Roberto Henrique Benedetti, Eduardo Buchele Rodrigues
BACKGROUND: Intravitreal injection (IVI) is a very common vitreoretinal procedure, and multiple injections are often required per patient. This systematic review was conducted to evaluate the effectiveness of various local anesthetic techniques in reducing pain during injection. METHODS: A systematic review was conducted based on searches of Cochrane, LILACS, PubMed, Scopus, Web of Science, and the gray literature (Google Scholar). The end search date was February 19, 2016, across all databases...
2017: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/28663893/functional-imaging-of-neuronal-activity-of-auditory-cortex-by-using-cal-520-in-anesthetized-and-awake-mice
#11
Jingcheng Li, Jianxiong Zhang, Meng Wang, Junxia Pan, Xiaowei Chen, Xiang Liao
The organization in the primary auditory cortex (Au1) is critical to the basic function of auditory information processing and integration. However, recent mapping experiments using in vivo two-photon imaging with different Ca(2+) indicators have reached controversial conclusions on this topic, possibly because of the different sensitivities and properties of the indicators used. Therefore, it is essential to identify a reliable Ca(2+) indicator for use in in vivo functional imaging of the Au1, to understand its functional organization...
May 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28663606/conscious-sedation-emerging-trends-in-pediatric-dentistry
#12
REVIEW
Joginder Pal Attri, Radhe Sharan, Vega Makkar, Kewal Krishan Gupta, Ranjana Khetarpal, Amar Parkash Kataria
Dental fear and anxiety is a common problem in pediatric patients. There is considerable variation in techniques used to manage them. Various sedation techniques using many different anesthetic agents have gained considerable popularity over the past few years. Children are not little adults; they differ physically, psychologically, and emotionally. The purpose of this review is to survey recent trends and concerning issues in the rapidly changing field of pediatric sedation. We will study the topic from the perspective of an anesthesiologist...
April 2017: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/28662278/topical-brimonidine-gel-for-extended-duration-local-anesthesia
#13
Hyun Jung Kwon, Sang Ju Lee, Jae Min Kim, Kui Young Park
Clinicians have been increasingly using topical anesthetic agents to diminish the pain associated with dermatologic and cosmetic procedures. Among the developed topical anesthetics, lidocaine-based products are the most widely used due to their ample pain relief and minimal side effects.(1) Many local anesthetics and additional techniques have been developed, but the limited duration of local anesthesia is still challenging to the practitioners. This article is protected by copyright. All rights reserved.
June 29, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28655605/gadolinium-enhanced-7-0%C3%A2-t-magnetic-resonance-imaging-assessment-of-the-aqueous-inflow-in-rat-eyes-in%C3%A2-vivo
#14
Lu Li, Yuxiang Yuan, Liwen Chen, Mu Li, Pingting Ji, Jieling Gong, Yin Zhao, Hong Zhang
The goal of this study was to calculate the anterior chamber volume and assess aqueous inflow in rat eyes in vivo, under anesthetic condition. Gadolinium-contrast agent (Gd-DTPA, 234.5 mg/ml) was administered to Sprague-Dawley rat eyes via anterior chamber injection or instillation of 234.5 or 117.25 mg/ml Gd-DTPA in 0.2% azone as eye drops, and changes of Gd signal visualized by 7.0 T magnetic resonance imaging (MRI). The safety of local application of Gd-DTPA and azone were performed after MRI scanning...
June 24, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28653424/anesthetic-ointment-only-lidocaine-prilocaine-instead-of-injectable-local-lidocaine-in-trans-radial-catheterization-a-viable-no-needle-alternative
#15
George Latsios, Kostas Toutouzas, Alexios S Antonopoulos, Eleni Melidi, Andreas Synetos, Georgia Vogiatzi, Aggeliki Stasinopoulou, Kostas Tsioufis, Eleftherios Tsiamis, Dimitrios Tousoulis
OBJECTIVE: The aim of the present study was to assess the level of access site pain in patients undergoing transradial coronary catheterization by using topical application of an anesthetic ointment (lidocaine/prilocaine-AO) compared to standard local anesthesia (LA) by means of injectable lidocaine. METHODS: We prospectively studied 444 patients undergoing elective trans-radial coronary angiography. The quality of analgesia was assessed using a visual analogue scale (VAS) immediately after the puncture and 30 min after the removal of the sheath...
June 26, 2017: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/28651550/a-novel-trpm8-agonist-relieves-dry-eye-discomfort
#16
Jee Myung Yang, Fengxian Li, Qin Liu, Marco Rüedi, Edward Tak Wei, Michael Lentsman, Hyo Seok Lee, Won Choi, Seong Jin Kim, Kyung Chul Yoon
BACKGROUND: Physical cooling of the eye surface relieves ocular discomfort, but translating this event to drug treatment of dry eye discomfort not been studied. Here, we synthesized a water-soluble TRPM8 receptor agonist called cryosim-3 (C3, 1-diisopropylphosphorylnonane) which selectively activates TRPM8 (linked to cooling) but not TRPV1 or TRPA1 (linked to nociception) and tested C3 in subjects with mild forms of dry eye disease. METHODS: A set of 1-dialkylphosphoryalkanes were tested for activation of TRPM8, TRPV1 and TRPA1 receptors in transfected cells...
June 26, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28645220/comparison-of-emla-cream-and-topical-lidocaine-tape-for-pain-relief-of-v-beam-laser-treatment
#17
Masaru Horikiri, Kazuki Ueda, Takao Sakaba
The authors compared the analgesic effects of two topical applications; Emla(®) cream (Sato Pharmaceutical Co. Ltd., Tokyo, Japan) and 60% lidocaine tape (Penles(®) tape; Maruho, Osaka, Japan). The authors examined 20 outpatients with capillary malformations. Emla(®) cream or Penles(®) tape was applied 1 h before laser irradiation using V-Beam. After V-Beam irradiation, pain intensity was measured using Pain Vision(®) (NIPRO, Osaka, Japan), while subjective pain was converted into numerical values using the VAS system...
June 23, 2017: Journal of Plastic Surgery and Hand Surgery
https://www.readbyqxmd.com/read/28631227/frequent-occurrence-of-pain-and-prescription-opioid-use-for-treatment-of-pain-among-women-with-and-at-risk-for-hiv-infection
#18
Anjali Sharma, Donald R Hoover, Qiuhu Shi, Jennie C I Tsao, Christopher Cox, Deborah R Gustafson, Kathleen Weber, Ruth M Greenblatt, Bradley E Aouizerat, Michael W Plankey
Pain is frequent and underreported among HIV+ women. We determined occurrence and severity of pain, and types of pain treatments used among HIV+ and HIV- women. Cross-sectional analyses of pain as measured by the Brief Pain Inventory Short Form, and related pain therapies nested in the Women's Interagency HIV Study (WIHS). Multiple variable linear regression models examined differences by HIV status in pain severity and pain interference in general activity, mood, ability to walk, work, relationships with others, sleep, and enjoyment of life...
June 19, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28628505/central-connections-of-the-lacrimal-functional-unit
#19
Catherine Willshire, Roger J Buckley, Anthony J Bron
PURPOSE: To study the contribution of each eye to the reflex tear response, after unilateral and bilateral topical anesthesia. METHOD: A closed-eye, modified Schirmer test was performed bilaterally in 8 normal subjects, in a controlled environment chamber set to 23°C, 45% relative humidity, and 0.08 m/s airflow. Eye drops were instilled into each eye 10 minutes before the Schirmer test. Experiments were as follows: 1) bilateral saline (control), 2) unilateral anesthesia (ipsilateral anesthetic; contralateral saline), and 3) bilateral anesthesia...
June 14, 2017: Cornea
https://www.readbyqxmd.com/read/28616796/comparison-of-surgeon-comfort-assessment-during-phacoemulsification-using-bilateral-topical-anesthesia-versus-ipsilateral-topical-anesthesia-a-randomized-controlled-study
#20
Rashim Mannan, Archna Pruthi, Sumeet Khanduja
AIM: To evaluate the effectiveness of bilateral use of topical anesthetic eye drops during phacoemulsification procedure as compared to use in one eye only. METHODS: This is a prospective double-blind randomized case study of 180 cases undergoing phacoemulsification under topical anesthesia using 0.5% proparacaine: Group 1 consisting of patients who had topical anesthetic eye drop instilled into the operating eye only and Group 2 consisting of patients who had both their eyes anesthetized using topical anesthetic eye drops...
June 14, 2017: International Ophthalmology
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