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https://www.readbyqxmd.com/read/28934084/outcome-of-icsi-with-motile-testicular-spermatozoa-obtained-through-microscopically-assisted-testicular-sperm-extraction-in-relation-to-the-ovarian-response
#1
E Erdem, M Karacan, A Usta, A Arvas, Z Cebi, T Camlibel
INTRODUCTION: To determine the relationship between AFC, basal FSH level, woman's age, the number of oocytes retrieved and the outcome of ICSI with testicular spermatozoa obtained with microscopically assisted testicular sperm extraction. MATERIAL AND METHODS: In this retrospective cohort study, a total of 340 couples who underwent ICSI treatment with testicular sperm were enrolled. Women aged?40years and the first cycles of couples were included. ICSI was performed with motile testicular spermatozoa obtained from 89 men with obstructive azoospermia and 251 men with nonobstructive azoospermia...
May 2017: Journal of gynecology obstetrics and human reproduction
https://www.readbyqxmd.com/read/28933712/volume-load-and-neuromuscular-fatigue-during-an-acute-bout-of-agonist-antagonist-paired-set-vs-traditional-set-training
#2
Gabriel A Paz, Daniel W Robbins, Carlos G de Oliveira, Martim Bottaro, Humberto Miranda
Paz, GA, Robbins, DW, de Oliveira, CG, Bottaro, M, and Miranda, H. Volume load and neuromuscular fatigue during an acute bout of agonist-antagonist paired-set vs. traditional-set training. J Strength Cond Res 31(10): 2777-2784, 2017-The purpose of this study was to investigate the acute effects of performing paired-set (PS) vs. traditional-set (TS) training over 3 consecutive sets, on volume load and electromyographic fatigue parameters of the latissimus dorsi, biceps brachii, pectoralis major, and triceps brachii muscles...
October 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28920822/a-retrospective-comparison-of-chemical-immobilization-with-thiafentanil-thiafentanil-azaperone-or-etorphine-acepromazine-in-captive-persian-fallow-deer-dama-dama-mesopotamica
#3
Roi Lapid, Roni King, Tali Bdolah-Abram, Yael Shilo-Benjamini
Records of 56 Persian fallow deer (Dama dama mesopotamica) immobilized for translocation were reviewed. Twenty-three were administered 0.05 ± 0.01 (mean ± SD) mg/kg thiafentanil (THIA), 20 were administered 0.045 ± 0.008 mg/kg thiafentanil combined with 0.19 ± 0.03 mg/kg azaperone (THIA-AZP), and 13 were administered 0.032 ± 0.04 mg/kg etorphine-acepromazine (ETOR-ACP) by intramuscular remote injection. Parameters recorded and compared between groups included induction and recovery times, heart rate, respiratory rate, rectal temperature, oxygen saturation, blood pressure, reflexes, quality of immobilization, and blood concentrations of lactate and glucose...
September 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28916148/chemokine-receptor-directed-imaging-and-therapy
#4
REVIEW
Andreas K Buck, Antje Stolzenburg, Heribert Hänscheid, Andreas Schirbel, Katharina Lückerath, Margret Schottelius, Hans-Jürgen Wester, Constantin Lapa
The C - X - C chemokine receptor 4 (CXCR4) and its natural ligand CXCL12 are key factors in the process of cell migration, homing of hematopoietic stem cells to the bone marrow, and represent important mediators of angiogenesis and cell proliferation. The CXCR4/CXCL12 interplay can be disrupted by CXCR4 antagonists such as Plerixafor which are already in daily clinical use, i.e. for mobilization and subsequent harvesting of hematopoietic progenitor cells and stem cell transplantation. In a pathological condition, involvement in the process of metastasis and homing of cancer cells to a protective niche has been described, making CXCR4 an attractive target for imaging and treatment of malignant diseases...
September 12, 2017: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/28904261/chemical-immobilization-of-free-ranging-and-captive-sunda-clouded-leopards-neofelis-diardi-with-two-anesthetic-protocols-medetomidine-ketamine-and-tiletamine-zolazepam
#5
Fernando Nájera, Andrew J Hearn, Joanna Ross, Diana A Ramírez Saldivar, Meaghan N Evans, Sergio Guerrero-Sánchez, Senthilvel K S S Nathan, Ignacio de Gaspar Simón, David W Macdonald, Benoit Goossens, Luis Revuelta Rueda
There is currently no available information regarding the veterinary management of Sunda clouded leopards (Neofelis diardi), either in captivity or in the wild. In this study, 12 Sunda clouded leopards were anesthetized between January 2008 and February 2014 for medical exams, and/or GPS-collaring. Seven wild-caught individuals were kept in captivity and 5 free-ranging animals were captured by cage traps. Two anesthesia combinations were used: medetomidine-ketamine (M-K) or tiletamine-zolazepam (T-Z). Atipamezole (0...
September 14, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28903472/gnrh-antagonist-versus-long-agonist-protocols-in-ivf-a-systematic-review-and-meta-analysis-accounting-for-patient-type
#6
C B Lambalk, F R Banga, J A Huirne, M Toftager, A Pinborg, R Homburg, F van der Veen, M van Wely
BACKGROUND: Most reviews of IVF ovarian stimulation protocols have insufficiently accounted for various patient populations, such as ovulatory women, women with polycystic ovary syndrome (PCOS) or women with poor ovarian response, and have included studies in which the agonist or antagonist was not the only variable between the compared study arms. OBJECTIVE AND RATIONALE: The aim of the current study was to compare GnRH antagonist protocols versus standard long agonist protocols in couples undergoing IVF or ICSI, while accounting for various patient populations and treatment schedules...
September 1, 2017: Human Reproduction Update
https://www.readbyqxmd.com/read/28893861/adrenal-venous-sampling-for-primary-aldosteronism-laboratory-medicine-best-practice
#7
Gregory Kline, Daniel T Holmes
Primary aldosteronism (PA) is the most common form of secondary hypertension and is critical to identify because when caused by an aldosterone-producing adenoma (APA) or another unilateral form, it is potentially curable, and even when caused by bilateral disease, antihypertensives more specific to PA treatment can be employed (ie, aldosterone antagonists). Identification of unilateral forms is not generally accomplished with imaging because APAs may be small and elude detection, and coincidental identification of a non-functioning incidentaloma contralateral to an APA may lead to removal of an incorrect gland...
September 11, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28890430/how-to-personalize-ovarian-stimulation-in-clinical-practice
#8
Giovanna Sighinolfi, Valentina Grisendi, Antonio La Marca
Controlled ovarian stimulation (COS) in in vitro fertilization (IVF) cycles is the starting point from which couple's prognosis depends. Individualization in follicle-stimulating hormone (FSH) starting dose and protocol used is based on ovarian response prediction, which depends on ovarian reserve. Anti-Müllerian hormone levels and the antral follicle count are considered the most accurate and reliable markers of ovarian reserve. A literature search was performed for studies that addressed the ability of ovarian reserve markers to predict poor and high ovarian response in assisted reproductive technology cycles...
September 1, 2017: Journal of the Turkish German Gynecological Association
https://www.readbyqxmd.com/read/28882371/comparison-of-subcutaneous-dexmedetomidine-midazolam-versus-alfaxalone-midazolam-sedation-in-leopard-geckos-eublepharis-macularius
#9
Grayson A Doss, Dustin M Fink, Kurt K Sladky, Christoph Mans
OBJECTIVE: To compare dexmedetomidine-midazolam with alfaxalone-midazolam for sedation in leopard geckos (Eublepharis macularius). STUDY DESIGN: Prospective, randomized, blinded, complete crossover study. ANIMALS: Nine healthy adult leopard geckos. METHODS: Geckos were administered a combination of dexmedetomidine (0.1 mg kg(-1)) and midazolam (1.0 mg kg(-1); treatment D-M) or alfaxalone (15 mg kg(-1)) and midazolam (1...
April 24, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/28877949/feasibility-randomised-multicentre-double-blind-double-dummy-controlled-trial-of-anakinra-an-interleukin-1-receptor-antagonist-versus-intramuscular-methylprednisolone-for-acute-gout-attacks-in-patients-with-chronic-kidney-disease-asgard-protocol-study
#10
Gowrie Balasubramaniam, Trisha Parker, David Turner, Mike Parker, Jonathan Scales, Patrick Harnett, Michael Harrison, Khalid Ahmed, Sweta Bhagat, Thiraupathy Marianayagam, Costantino Pitzalis, Christian Mallen, Edward Roddy, Mike Almond, Bhaskar Dasgupta
INTRODUCTION: Acute gout occurs in people with chronic kidney disease, who are commonly older people with comorbidities such as hypertension, heart disease and diabetes. Potentially harmful treatments are administered to these vulnerable patients due to a lack of clear evidence. Newly available treatment that targets a key inflammatory pathway in acute gout attacks provides an opportunity to undertake the first-ever trial specifically looking treating people with kidney disease. This paper describes the protocol for a feasibility randomised controlled trial (RCT) comparing anakinra, a novel interleukin-1 antagonist versus steroids in people with chronic kidney disease (ASGARD)...
September 5, 2017: BMJ Open
https://www.readbyqxmd.com/read/28874104/ovarian-stimulation-in-patients-with-cancer-impact-of-letrozole-and-brca-mutations-on-fertility-preservation-cycle-outcomes
#11
Volkan Turan, Giuliano Bedoschi, Volkan Emirdar, Fred Moy, Kutluk Oktay
BACKGROUND: Aromatase inhibitors (AI) have been introduced to reduce estrogen exposure in women with estrogen-sensitive cancer undergoing ovarian stimulation for oocyte/embryo cryopreservation. There have been questions regarding whether the addition of AI and the presence of BRCA mutations affect cycle outcomes. We sought to determine the impact of letrozole and BRCA mutations on fertility preservation (FP) cycle outcomes of patients undergoing ovarian stimulation with an antagonist protocol...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28866370/acute-effects-of-direct-inhibitory-pressure-over-the-biceps-brachii-myotendinous-junction-on-skeletal-muscle-activation-and-force-output
#12
Emiliano Cè, Stefano Longo, Emily McCoy, Angela Valentina Bisconti, Davide Tironi, Eloisa Limonta, Susanna Rampichini, Marco Rabuffetti, Fabio Esposito
Force (F) reduction is reported with myotendinous junction (MTJ) manipulation. Autogenic inhibition reflex (AIR) activation is supposed to be the main mechanism. Still, its role remains unclear. The study aimed at assessing the effects of MTJ direct inhibitory pressure (DIP) on neuromuscular activation and F in the elbow flexor (agonist) and extensor (antagonist) muscles. After maximum voluntary contraction (MVC) assessment, thirty-five participants randomly performed submaximal contractions at 20, 40, 60, and 80% MVC...
August 12, 2017: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/28861038/alleviation-of-motor-impairments-in-patients-with-cerebral-palsy-acute-effects-of-whole-body-vibration-on-stretch-reflex-response-voluntary-muscle-activation-and-mobility
#13
Anne Krause, Eckhard Schönau, Albert Gollhofer, Ibrahim Duran, Anja Ferrari-Malik, Kathrin Freyler, Ramona Ritzmann
INTRODUCTION: Individuals suffering from cerebral palsy (CP) often have involuntary, reflex-evoked muscle activity resulting in spastic hyperreflexia. Whole-body vibration (WBV) has been demonstrated to reduce reflex activity in healthy subjects, but evidence in CP patients is still limited. Therefore, this study aimed to establish the acute neuromuscular and kinematic effects of WBV in subjects with spastic CP. METHODS: 44 children with spastic CP were tested on neuromuscular activation and kinematics before and immediately after a 1-min bout of WBV (16-25 Hz, 1...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28839521/salivary-cytokine-levels-in-early-gingival-inflammation
#14
Daniel Belstrøm, Christian Damgaard, Eija Könönen, Mervi Gürsoy, Palle Holmstrup, Ulvi Kahraman Gürsoy
Salivary protein levels have been studied in periodontitis. However, there is lack of information on salivary cytokine levels in early gingival inflammation. The aim of this study was to determine salivary levels of vascular endothelial growth factor (VEGF), interleukin (IL)-8, monocyte chemoattractant protein (MCP)-1, IL-1β, and IL-1 receptor antagonist (IL-1Ra) in gingival inflammation. Twenty-eight systemically and orally healthy nonsmokers abstained from oral hygiene protocols for 10 days. After that, self-performed cleaning was resumed for 14 days...
2017: Journal of Oral Microbiology
https://www.readbyqxmd.com/read/28837035/estradiol-use-in-the-luteal-phase-and-its-effects-on-pregnancy-rates-in-ivf-cycles-with-gnrh-antagonist-a-systematic-review
#15
REVIEW
Lanna Marla Andrade Pinheiro, Priscilla da Silva Cândido, Tássia Camila Moreto, Wanessa Gonzaga Di Almeida, Eduardo Camelo de Castro
For all the steps of in vitro fertilization to occur successfully, factors such as the quality of retrieved oocytes and endometrial receptivity to the embryo must be ensured. Current studies have shown that endometrial receptivity can be optimized using dedicated exogenous progesterone for luteal phase support in assisted reproduction cycles. But it has not yet been established the benefits of additional use of estradiol in this support. Analyzing pituitary suppression protocols that employ GnRH antagonists, this review will address literature publications between the years 2000-2016, shedding light on this issue to answer questions about the benefits of supplementation...
September 1, 2017: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/28837031/can-ovarian-double-stimulation-in-the-same-menstrual-cycle-improve-ivf-outcomes
#16
Maria Cecília de Almeida Cardoso, Alessandra Evangelista, Cássio Sartório, George Vaz, Caio Luis Vieira Werneck, Fernando Marques Guimarães, Paulo Gallo de Sá, Maria Cecília Erthal
OBJECTIVE: To evaluate the double-stimulation protocol efficacy over conventional ovarian stimulation in recovering a more adequate number of oocytes and increase the number of embryos to be transferred or to be genetically analyzed. METHODS: A retrospective and comparative study with 13 patients who underwent unsuccessful in vitro fertilization (IVF) cycles with a conventional antagonist ovarian stimulation protocol and repeat the attempt with a double stimulation protocol...
September 1, 2017: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/28836158/associations-of-proton-pump-inhibitors-and-h2-receptor-antagonists-with-chronic-kidney-disease-a-meta-analysis
#17
Karn Wijarnpreecha, Charat Thongprayoon, Supavit Chesdachai, Panadeekarn Panjawatanana, Patompong Ungprasert, Wisit Cheungpasitporn
BACKGROUND/AIMS: The aim of this meta-analysis was to assess the risks of chronic kidney disease (CKD) and/or end-stage kidney disease (ESRD) in patients who are taking proton-pump inhibitors (PPIs) and/or H2 receptor antagonists (H2RAs). METHODS: Comprehensive literature review was conducted utilizing MEDLINE and EMBASE databases through April 2017 to identify all studies that investigated the risks of CKD or ESRD in patients taking PPIs/H2RAs versus those without PPIs/H2RAs...
August 23, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28835940/pregnancy-outcome-of-delayed-start-gnrh-antagonist-protocol-versus-gnrh-antagonist-protocol-in-poor-responders-a-clinical-trial-study
#18
Abbas Aflatoonian, Aflatoonian Hosseinisadat, Ramesh Baradaran, Maryam Farid Mojtahedi
BACKGROUND: Management of poor-responding patients is still major challenge in assisted reproductive techniques (ART). Delayed-start GnRH antagonist protocol is recommended to these patients, but little is known in this regards. OBJECTIVE: The goal of this study was assessment of delayed-start GnRH antagonist protocol in poor responders, and in vitro fertilization (IVF) outcomes. MATERIALS AND METHODS: This randomized clinical trial included sixty infertile women with Bologna criteria for ovarian poor responders who were candidate for IVF...
April 2017: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/28835432/the-role-of-ca-2-activated-cl-current-in-tone-generation-in-the-rabbit-corpus-cavernosum
#19
Karen I Hannigan, Caoimhin S Griffin, Roddy L Large, Gerard P Sergeant, Mark A Hollywood, Noel G McHale, Keith D Thornbury
Rabbit corpus cavernosum smooth muscle (RCCSM) cells express channels that produce Ca(2+)-activated Cl(-) (IClCa) current, but low sensitivity to conventional antagonists have made its role in tone generation difficult to evaluate. We have re-examined this question using two new generation IClCa blockers, T16Ainh-A01 and CaCCinh-A01. Isolated RCCSM cells were studied using the perforated patch method. Current-voltage protocols revealed both L-type Ca(2+) current and IClCa T16Ainh-A01 and CaCCinh-A01 (10 M) reduced IClCa by ~85%, while 30 M abolished it...
August 23, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/28832723/is-forced-swimming-immobility-a-good-endpoint-for-modeling-negative-symptoms-of-schizophrenia-study-of-sub-anesthetic-ketamine-repeated-administration-effects
#20
Gilda Neves, Milene Borsoi, Camila B Antonio, Mariana A Pranke, Andresa H Betti, Stela M K Rates
Immobility time in the forced swimming has been described as analogous to emotional blunting or apathy and has been used for characterizing schizophrenia animal models. Several clinical studies support the use of NMDA receptor antagonists to model schizophrenia in rodents. Some works describe the effects of ketamine on immobility behavior but there is variability in the experimental design used leading to controversial results. In this study, we evaluated the effects of repeated administration of ketamine sub-anesthetic doses in forced swimming, locomotion in response to novelty and novel object recognition, aiming a broader evaluation of the usefulness of this experimental approach for modeling schizophrenia in mice...
August 17, 2017: Anais da Academia Brasileira de Ciências
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