keyword
MENU ▼
Read by QxMD icon Read
search

Chronic wound healing

keyword
https://www.readbyqxmd.com/read/29327540/-analysis-on-the-effect-of-surgical-cleaning-combined-with-external-fixator-for-the-treatment-of-post-traumatic-heterotopic-ossification-of-elbow-joint
#1
Liang Yan, Jian-Lei Zhao, Shang-Zeng Wang, Li-Na Feng
OBJECTIVE: To evaluate the clinical efficacy of surgical treatment using a combined medial and lateral approach combined with an external fixator for the treatment of post-traumatic heterotopic ossification(HO) in patients with stiff elbow joints. METHODS: Surgical release using the combined medial and lateral approach combined with external fixation for the treatment of HO and elbow stiffness in 26 patients from July 2010 to December 2013. The study group included 18 males and 8 females, with an average age 38...
January 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29325995/acetylshikonin-from-zicao-attenuates-cognitive-impairment-and-hippocampus-senescence-in-d-galactose-induced-aging-mouse-model-via-upregulating-the-expression-of-sirt1
#2
Qisen Li, Jiacheng Zeng, Meiling Su, Yu He, Banghao Zhu
Zicao acts as a pleiotropic medicine in various diseases due to its particular pharmacological properties, including anti-inflammatory, anti-tumor, anti-oxidative, and wound healing effects. However, few studies have focused on the function in neurodegenerative diseases of Zicao. In this study, we investigated the neuroprotective effect of Acetylshikonin (AS) from Zicao on the hippocampus of the D-galactose (D-gal)-induced sub-acute aging mouse model of Alzheimer's disease (AD). The aging model was established in male Kunming mice by subcutaneous injection of D-gal (150 mg/kg/d) for 60 days, and the mice were given AS (270, 540 and 1080 mg/kg/d) or distilled water intragastrically for 30 days after 30 days of D-gal injection...
January 8, 2018: Brain Research Bulletin
https://www.readbyqxmd.com/read/29325465/prevalence-of-positive-quantiferon-gold-in-tube-testing-in-hidradenitis-suppurativa
#3
Tina Boortalary, Kanchan Misra, Sean McNish, Derek Jones, Victoria K Shanmugam
Hidradenitis suppurativa (HS) is a chronic, recurrent, inflammatory disease of the apocrine sweat glands. Tumor necrosis factor-alpha (TNF-α) inhibitors are commonly used to treat HS. However, prior to initiating therapy patients must be screened for mycobacterium tuberculosis (mTB) exposure. Several mTB screening tests based on interferon gamma release assays are commercially available, but the performance of these assays in the HS population is unknown. The purpose of this study was to investigate the performance of the QuantiFERON gold in-tube assay (QFT-GIT) in a cohort of patients with Hidradenitis suppurativa (HS)...
January 12, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29324934/stem-cells-therapy-the-future-in-the-management-of-systemic-sclerosis-a-case-report
#4
Jung In Song, Silvanie Volz, Maria Eirini Liodaki, Peter Mailänder, Konstantinos Kalousis
OBJECTIVE: Systemic sclerosis (SSc) is a connective tissue disorder of unknown etiology, with heterogeneous clinical manifestations and chronic and often progressive course. The diffuse cutaneous form of SSc (dcSSc) is characterized by thickening of the skin (scleroderma) and distinctive involvement of multiple internal organs. Patients with limited cutaneous SSc (lcSSc) generally have long-standing Raynaud's phenomenon before other manifestations of SSc appear. Over the last decade the Interest of adipose-derived cell therapy in regenerative medicine has increased continuously...
September 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29324425/comparison-of-a-saline-coupled-bipolar-sealer-versus-traditional-electrosurgery-in-a-porcine-model-of-chronic-wound-healing
#5
Darvin J Griffin, Palaniswamy Vijay, Molly Speltz, Nicole Kirchhof, Joshua G Vose
OBJECTIVE: This study examines the healing dynamics of in vivo porcine muscle tissue wounds hemostatically treated with a saline-coupled bipolar tissue sealer (SCBS) compared with traditional electrosurgical (ES) coagulation. MATERIALS AND METHODS: Six cutaneous incisions were created on the dorsum of 28 adult male Yorkshire swine. The underlying muscle tissue was incised with a cold scalpel then treated with either SCBS (at 170 W) or traditional ES (at Coag 45 W)...
December 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/29324424/larval-therapy-for-chronic-cutaneous-ulcers-historical-review-and-future-perspectives
#6
Edoardo Raposio, Sara Bortolini, Lara Maistrello, Donato A Grasso
Cutaneous ulcers tend to become chronic and have a profound impact on quality of life. These wounds may become infected and lead to greater morbidity and even mortality. In the past, larvae (ie, maggots) of certain common flies (Lucilia sericata and Lucilia cuprina) were considered useful in ulcer management because they only remove necrotic tissue while promoting healthy tissue in the wound bed, thus helping wounds heal faster. Recently, maggots from several other fly species (Calliphora vicina, Calliphora vomitoria, Phormia regina, Chrysomya albiceps, Sarcophaga carnaria, and Hermetia illucens) have been shown in vitro to possess characteristics (ie, debridement efficacy and putative antimicrobial potentialities) that make them suitable candidates for possible use in clinical practice...
December 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/29322404/in-vivo-models-of-inflammatory-bowel-disease-and-colitis-associated-cancer
#7
Ka Yee Fung, Tracy Putoczki
A single layer of epithelial cells separates luminal antigens from the host immune system throughout the gastrointestinal tract. A breakdown in the integrity of the epithelial barrier can lead to chronic inflammation, which is associated with numerous complications including cancer. Here we describe three experimental protocols to chemically induce acute and chronic inflammatory bowel disease (IBD) symptoms and colitis-associated colorectal cancer (CRC) progression. These in vivo mouse models are based on the induction of damage to the colonic epithelium, resulting in an inflammatory and wound healing response...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29321021/silver-pig-skin-nanocomposites-and-mesenchymal-stem-cells-suitable-antibiofilm-cellular-dressings-for-wound-healing
#8
Mario Alberto Pérez-Díaz, Phaedra Silva-Bermudez, Binisa Jiménez-López, Valentín Martínez-López, Yaaziel Melgarejo-Ramírez, Ana Brena-Molina, Clemente Ibarra, Isabel Baeza, M Esther Martínez-Pardo, M Lourdes Reyes-Frías, Erik Márquez-Gutiérrez, Cristina Velasquillo, Gabriel Martínez-Castañon, Fidel Martinez-Gutierrez, Roberto Sánchez-Sánchez
BACKGROUND: Treatment of severe or chronic skin wounds is an important challenge facing medicine and a significant health care burden. Proper wound healing is often affected by bacterial infection; where biofilm formation is one of the main risks and particularly problematic because it confers protection to microorganisms against antibiotics. One avenue to prevent bacterial colonization of wounds is the use of silver nanoparticles (AgNPs); which have proved to be effective against non-multidrug-resistant and multidrug-resistant bacteria...
January 10, 2018: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29320588/a-guide-to-tissue-engineered-skin-substitutes
#9
Penelope J Kallis, Adam J Friedman, Hadar Lev-Tov
<p>Wounds that exhibit delayed healing have a tremendous impact on health care expenditures and place patients at serious risk for severe complications including death. The healing of a chronic wound requires the restoration of multiple factors that normally work in concert to repair the damaged skin barrier. Skin substitutes have shown great promise for use as adjunctive therapies for refractory wounds by providing cells, soluble mediators, and extracellular matrix materials needed to stimulate healing...
January 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29319719/a-new-low-cost-negative-pressure-wound-therapy-versus-a-commercially-available-therapy-device-widely-used-to-treat-complex-traumatic-injuries-a-prospective-randomized-non-inferiority-trial
#10
Fabio Kamamoto, Ana Lucia Munhoz Lima, Marcelo Rosa de Rezende, Rames Mattar-Junior, Marcos de Camargo Leonhardt, Kodi Edson Kojima, Carla Chineze Dos Santos
OBJECTIVES: Negative-pressure wound therapy has been widely adopted to reduce the complexity of treating a broad range of acute and chronic wounds. However, its cost is high. The objective of this study was to evaluate the following two different methods of negative-pressure wound therapy in terms of healing time: a low-cost method of negative-pressure wound therapy (a pressure stabilizer device connected to a hospital wall-vacuum system with a gauze-sealed dressing, USP) and the standard of care (vacuum-assisted closure, VAC)...
December 2017: Clinics
https://www.readbyqxmd.com/read/29316701/the-effect-of-cryopreserved-human-placental-tissues-on-biofilm-formation-of-wound-associated-pathogens
#11
Yong Mao, Anya Singh-Varma, Tyler Hoffman, Sandeep Dhall, Alla Danilkovitch, Joachim Kohn
Biofilm, a community of bacteria, is tolerant to antimicrobial agents and ubiquitous in chronic wounds. In a chronic DFU (Diabetic Foot Ulcers) clinical trial, the use of a human cryopreserved viable amniotic membrane (CVAM) resulted in a high rate of wound closure and reduction of wound-related infections. Our previous study demonstrated that CVAM possesses intrinsic antimicrobial activity against a spectrum of wound-associated bacteria under planktonic culture conditions. In this study, we evaluated the effect of CVAM and cryopreserved viable umbilical tissue (CVUT) on biofilm formation of S...
January 8, 2018: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/29316594/biofilms-their-role-and-treatment-options-in-the-chronic-non-healing-wound
#12
Michael F Moore
The discovery of the existence of biofilms in the 1970s has resulted in a greater understanding of how bacteria form a synergistic relationship to facilitate their survival by incorporating and sharing the individual attributes that individual bacteria have with the polymicrobial flora that composes the biofilm. Advances in molecular biology have aided in delineating complexity of biofilms, but the abundance and plethora of the microbial world provides an ongoing and daunting task. The enormity of this task is reflected in the chronic non-healing wound, as it is estimated that 60% of all chronic non-healing wounds have a biofilm component...
December 22, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/29305678/the-role-of-adipose-derived-stem-cells-in-a-self-organizing-3d-model-with-regard-to-human-soft-tissue-healing
#13
Martin Oberringer, Monika Bubel, Martina Jennewein, Silke Guthörl, Tamara Morsch, Sophie Bachmann, Wolfgang Metzger, Tim Pohlemann
The clinical phenomenon of inadequate soft tissue healing still remains an important issue. The occurrence of chronic wounds is correlated to the life span, which is still increasing in western countries. Tissue engineering products containing adipose-derived stem cells are discussed as a promising therapeutic approach. Several studies confirmed the value of these cells for soft tissue healing improvement, suggesting a paracrine as well as a direct effect on vessel repair and angiogenesis. In an attempt to figure out specific effects of adipose-derived stem cells on dermal microvascular endothelial cells with respect to the different phases of soft tissue healing, we designed a 3D in vitro model on the basis of spheroids...
January 5, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29303551/engineering-bioinspired-antioxidant-materials-promoting-cardiomyocyte-functionality-and-maturation-for-tissue-engineering-application
#14
Parvaiz Ahmad Shiekh, Anamika Singh, Ashok Kumar
Oxidative stress plays an important role in various pathological conditions such as wound healing, inflammation, myocardial infarction and biocompatibility of the materials. Antioxidant polymers to attenuate oxidative stress is an emerging field of biomaterial research with a huge impact in the field of tissue engineering and regenerative medicine. We describe here the fabrication and evaluation of an elastomeric antioxidant polyurethane (PUAO) for tissue engineering applications. Uniaxial and cyclic tensile testing, thermal analysis, degradation, cytotoxicity and antioxidant analysis was carried out...
January 5, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29301804/recurrent-hospitalisations-in-a-rare-case-of-hemicorporectomy-a-challenging-case-for-medical-management
#15
Ajit Thakur, Brittney Elliott, Rohan Naik, Nabeel Khan, Shayna McQuaid, Camelia Arsene
Hemicorporectomy, or translumbar amputation, is a radical surgery involving the dissection of the body at the waist and is usually reserved for complex medical conditions including locally invasive malignancy and terminal pelvic osteomyelitis. Only 71 cases have previously been reported. We present a rare case of hemicorporectomy in a 53-year-old patient with terminal pelvic osteomyelitis which occurred after he suffered a gunshot wound at T6 causing paraplegia at the age of 31. Unfortunately, this patient continued to suffer recurrent hospitalisations and sepsis events secondary to chronic, non-healing advanced pressure ulcers and complicated urinary tract infections despite repeated courses of broad-spectrum intravenous antibiotics and surgical debridements...
January 4, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29290068/topical-minoxidil-versus-topical-diltiazem-for-chemical-sphincterotomy-of-chronic-anal-fissure-a-prospective-randomized-double-blind-clinical-trial
#16
Mina Alvandipour, Shahram Ala, Mehdi Khalvati, Jamshid Yazdanicharati, Neda Koulaeinejad
BACKGROUND: Anal fissure is a common anorectal problem causing severe pain and discomfort to the patients. Chemical sphincterotomy has emerged as a noninvasive alternative to the surgical methods of fissure treatment. The objective of this study was evaluation of the efficacy and the adverse effects of topically applied minoxidil in chemical sphincterotomy of chronic anal fissure in comparison with topical diltiazem. METHODS: A total of 88 patients with chronic anal fissure aged between 15 and 65 years were included in this double-blind, randomized clinical trial and were randomly assigned to either 0...
December 31, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29289704/contribution-of-photodynamic-therapy-in-wound-healing-a-systematic-review
#17
REVIEW
Vanessa Nesi-Reis, Daniele Stéfanie Sara Lopes Lera-Nonose, Jully Oyama, Marielle Priscila Paula Silva-Lalucci, Izabel Galhardo Demarchi, Sandra Mara Alessi Aristides, Jorge Juarez Vieira Teixeira, Thaís Gomes Verzignassi Silveira, Maria Valdrinez Campana Lonardoni
OBJECTIVE: We researched articles that used photodynamic therapy (PDT) in skin wound healing in humans. METHODS: The systematic review was conducted throughout scientific articles that investigated the action of PDT on wound healing in humans, published from July 2005 to March 2017, in the data bases PubMed and LILACS. RESULTS: The main types of wound described in selected articles in this review were chronic ulcer, non-melanoma skin cancer...
December 28, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29289644/matrix-metalloproteinases-and-liver-fibrosis-translational-aspects
#18
REVIEW
Elke Roeb
Liver fibrosis, a reversible wound-healing response to chronic cellular injury, reflects a balance between liver repair and progressive substitution of the liver parenchyma by scar tissue. Complex mechanisms that underlie liver fibrogenesis are summarized to provide the basis for generating targeted therapies to reverse fibrogenesis and improve the outcomes of patients with chronic liver disease. This minireview presents some pathophysiological aspects of liver fibrosis as a dynamic process and elucidates matrix metalloproteinases (MMPs) and their role within as well as beyond matrix degradation...
December 28, 2017: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29287803/transcriptional-profile-of-in-vitro-expanded-human-epidermal-progenitor-cells-for-the-treatment-of-non-healing-wounds
#19
Paulina Langa, Anna Wardowska, Jacek Zieliński, Justyna Podolak-Popinigis, Piotr Sass, Paweł Sosnowski, Karolina Kondej, Alicja Renkielska, Paweł Sachadyn, Piotr Trzonkowski, Michał Pikuła
BACKGROUND: Epidermal progenitor cells (EPCs) have been under extensive investigation due to their increasing potential of application in medicine and biotechnology. Cultured human EPCs are used in the treatment of chronic wounds and have recently became a target for gene therapy and toxicological studies. One of the challenges in EPCs culture is to provide a high number of undifferentiated, progenitor cells displaying high viability and significant biological activity. OBJECTIVES: The goal of this study was to characterize the in vitro cultured progenitor cells and to assess whether the cells with the progenitor phenotype are able to enhance wound healing...
December 13, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29280095/the-efficacy-of-tetrasodium-edta-on-biofilms
#20
S L Percival, A-M Salisbury
The aetiology of delayed wound healing characteristic of a chronic wound is relatively unknown but is thought to be due to a combination of the patient's underlying pathophysiology and external factors including infection and biofilm formation. The invasion of the wound by the hosts' resident microbiome and exogenous microorganisms can lead to biofilm formation. Biofilms have increased tolerance to antimicrobial interventions and constitute a concern to chronic wound healing. Consequently, anti-biofilm technologies with proven efficacy in areas outside of wound care need evaluation to determine whether their efficacy could be relevant to the control of biofilms in wounds...
December 27, 2017: Advances in Experimental Medicine and Biology
keyword
keyword
65944
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"