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Chronic wound healing

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https://www.readbyqxmd.com/read/29777958/sssupramolecular-poly-acrylic-acid-f127-hydrogel-with-hydration-controlled-nitric-oxide-release-for-enhancing-wound-healing
#1
Mathilde Champeau, Valéria Póvoa, Lucas Militão, Flávia Cabrini, Guilherme F Picheth, Florian Meneau, Carlos P Jara, Eliana P de Araujo, Marcelo G de Oliveira
Topical nitric oxide (NO) delivery has been shown to accelerate wound healing. However, delivering NO to wounds at appropriate rates and doses requires new biomaterial-based strategies. Here, we describe the development of supramolecular interpolymer complex hydrogels comprising PEO-PPO-PEO (F127) micelles embedded in a poly(acrylic acid) (PAA) matrix, with S-nitrosoglutathione (GSNO) molecules dissolved in the hydrophilic domain. We show that PAA:F127/GSNO hydrogels start releasing NO upon hydration at rates controlled by their rates of water absorption...
May 16, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29776425/combined-application-of-latissimus-dorsi-myocutaneous-flap-and-iliac-bone-flap-in-the-treatment-of-chronic-osteomyelitis-of-the-lower-extremity
#2
Jihui Ju, Lei Li, Rong Zhou, Ruixing Hou
BACKGROUND: To evaluate the clinical efficacy and safety of latissimus dorsi myocutaneous flap (stage I) combined with iliac bone flap (stage II) in the treatment of chronic osteomyelitis of the lower extremity. METHODS: Clinical data of 18 patients undergoing latissimus dorsi myocutaneous flap in combination with iliac bone flap grafting were retrospectively analyzed. Among them, 2 patients developed chronic osteomyelitis of the lower segment of the femur, 4 were diagnosed with chronic osteomyelitis of the tibial plateau, and 12 with chronic osteomyelitis of the lower segment of the tibia...
May 18, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29772758/antioxidant-capacity-of-rigenase-%C3%A2-a-specific-aqueous-extract-of-triticum-vulgare
#3
Immacolata Antonucci, Gabriella Fiorentino, Patrizia Contursi, Massimiliano Minale, Rodolfo Riccio, Salvatore Riccio, Danila Limauro
Reactive species of oxygen (ROS), responsible for oxidative stress, accumulate in various tissues damaged by burns, decubitus ulcers, and vascular lesions. Antioxidants play an important and well-documented role in healing of chronic and acute wounds. Rigenase® , a specific extract of Triticum vulgare manufactured by Farmaceutici Damor, is employed in products used for the regeneration of tissue injuries. In this work, we show that Rigenase® exhibits a scavenging effect toward free radicals, thus pointing to its relevant antioxidant activity...
May 17, 2018: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/29772321/use-of-polidocanol-endovenous-microfoam-to-improve-hemodynamics-and-symptomology-in-patients-with-challenging-clinical-presentations-a-case-series
#4
Paul E Davis, John Phillips, Raghu Kolluri
BACKGROUND: We performed a retrospective review of treatment effects with FDA-approved Polidocanol endovenous microfoam (PEM, Varithena® 1%) on venous symptomology in ten (N=10) C3-C6 patients with chronic venous insufficiency (CVI) and concomitant complex disease/pathology that limited the use of endothermal ablation (ETA). METHODS: Pathology included: risk of bruising or bleeding, severe lipodermatosclerosis (LDS), Hydradenitis Suppurativa, chronic fibrosis of the vein from prior superficial thrombosis, risk for nerve injury and failed prior ETA...
May 14, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29767913/development-of-coverage-and-its-evaluation-in-the-treatment-of-chronic-wounds
#5
Marcia Diana Umebayashi Zanoti, Helena Megumi Sonobe, Sidney José Lima Ribeiro, Ana Maria Minarelli Gaspar
OBJECTIVES: To describe the development of the bacterial cellulose coating with anti-inflammatory Ibuprofen (BC/Ibu) and to evaluate the cicatrization process with its use in patients with chronic wounds of venous and diabetic etiology. METHODS: Longitudinal descriptive study. The cellulose membrane, cultivated with bacteria Gluconacetobacter xylinus and with incorporation of Ibuprofen, was used in the treatment of patients with chronic wounds in public health services in a Brazilian municipality...
October 2017: Investigación y Educación en Enfermería
https://www.readbyqxmd.com/read/29767448/development-and-validation-of-a-fast-and-sensitive-uhplc-esi-ms-method-for-the-simultaneous-quantification-of-spironolactone-and-its-metabolites-in-ocular-tissues
#6
Naoual Dahmana, Doris Gabriel, Robert Gurny, Yogeshvar N Kalia
Glucocorticoids are a mainstay for the treatment of immune-mediated conditions and inflammatory diseases. However, their chronic use causes numerous side-effects including delays in corneal and cutaneous wound healing. This is attributed to off-target agonism of the mineralocorticoid receptor, which can be reduced by co-administration of a mineralocorticoid receptor antagonist such as spironolactone. The aim of this study was to develop a fast, selective and sensitive UHPLC-ESI-MS method for the simultaneous quantification of spironolactone, its active metabolites - 7α-thiomethylspironolactone and canrenone, the latter's water-soluble prodrug potassium canrenoate, and the synthetic glucocorticoid, dexamethasone, in corneal samples (17α-methyltestosterone served as an internal standard)...
May 16, 2018: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29765329/the-role-of-macrophages-in-acute-and-chronic-wound-healing-and-interventions-to-promote-pro-wound-healing-phenotypes
#7
REVIEW
Paulina Krzyszczyk, Rene Schloss, Andre Palmer, François Berthiaume
Macrophages play key roles in all phases of adult wound healing, which are inflammation, proliferation, and remodeling. As wounds heal, the local macrophage population transitions from predominantly pro-inflammatory (M1-like phenotypes) to anti-inflammatory (M2-like phenotypes). Non-healing chronic wounds, such as pressure, arterial, venous, and diabetic ulcers indefinitely remain in inflammation-the first stage of wound healing. Thus, local macrophages retain pro-inflammatory characteristics. This review discusses the physiology of monocytes and macrophages in acute wound healing and the different phenotypes described in the literature for both in vitro and in vivo models...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29761573/using-fat-to-fight-disease-a-systematic-review-of-non-homologous-adipose-derived-stromal-stem-cell-therapies
#8
REVIEW
Marjorie E Bateman, Amy L Strong, Jeffrey M Gimble, Bruce A Bunnell
OBJECTIVE: The objective of this review is to describe the safety and efficacy of ASC and SVF in treating common diseases and the next steps in research that must occur prior to clinical use. EVIDENCE REVIEW: Pubmed, Ovid Medline, Embase, Web of Science, and the Cochrane Library were searched for articles about use of SVF or ASC for disease therapy published between 2012 and 2017. One meta-analysis, 2 randomized controlled trials, and 16 case series were included, representing 844 human patients...
May 15, 2018: Stem Cells
https://www.readbyqxmd.com/read/29757677/microrna-dysregulation-in-pulmonary-arteries-from-copd-relationships-with-vascular-remodeling
#9
Melina M Musri, Núria Coll-Bonfill, Bradley A Maron, Víctor I Peinado, Ruisheng Wang, Jordi Altirriba, Isabel Blanco, William M Oldham, Olga Tura-Ceide, Jessica García-Lucio, Benjamin de la Cruz-Thea, Gunter Meister, Joseph Loscalzo, Joan A Barberà
BACKGROUND: Pulmonary vascular remodeling is an angiogenic-related process involving changes in smooth muscle cell (SMC) homeostasis, which is frequently observed in chronic obstructive pulmonary disease (COPD). MicroRNAs (miRNAs) are small non-coding RNAs that regulate mRNA expression levels of many genes leading to the manifestation of cell identity and specific cellular phenotypes. Here we evaluate the miRNA expression profiles of pulmonary arteries (PA) of patients with COPD and its relationship with the regulation of SMC phenotypic change...
May 14, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29757659/bone-marrow-derived-mesenchymal-stem-cells-promoted-cutaneous-wound-healing-by-regulating-keratinocyte-migration-via-the-%C3%AE-2-adrenergic-receptor-signaling
#10
Jiahui Huo, Sujing Sun, Zhijun Geng, Wei Sheng, Runkai Chen, Kui Ma, Xiaoyan Sun, Xiaobing Fu
Mesenchymal stem cells (MSCs) play an important role in the cutaneous wound healing; however, the functional mechanisms involved in the healing process are poorly understood. A series of studies indicate that keratinocytes which migrate into the wound bed rely on an epithelial-mesenchymal transition (EMT)-like process to initiate re-epithelialization. We therefore examined whether bone marrow-derived MSCs (BMSCs) could affect biological behavior and induce EMT-like characteristics in the human epidermal keratinocytes (HEKs) and in the immortalized human keratinocyte cell line HaCaT cells; and we investigated the signaling pathways of BMSC-mediated phenotypic changes...
May 14, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29756537/use-of-negative-pressure-wound-therapy-in-a-chronic-leg-wound-with-coexisting-rheumatoid-arthritis-a-case-study
#11
Dariusz Bazaliński, Paweł Więch, Beata Barańska, Monika Binkowska-Bury
We present a case of a 69-year-old woman with rheumatoid arthritis. The patient's condition was managed with steroid therapy for more than 12 years. She had a coexisting infected chronic ulceration in the left leg, which was treated with negative pressure wound therapy for 52 days. Use of this therapy within the wound reduced exudate and the bacterial count, which dramatically accelerated the process of wound healing.
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29755977/wearable-technology-for-chronic-wound-monitoring-current-dressings-advancements-and-future-prospects
#12
REVIEW
Matthew S Brown, Brandon Ashley, Ahyeon Koh
Chronic non-healing wounds challenge tissue regeneration and impair infection regulation for patients afflicted with this condition. Next generation wound care technology capable of in situ physiological surveillance which can diagnose wound parameters, treat various chronic wound symptoms, and reduce infection at the wound noninvasively with the use of a closed loop therapeutic system would provide patients with an improved standard of care and an accelerated wound repair mechanism. The indicating biomarkers specific to chronic wounds include blood pressure, temperature, oxygen, pH, lactate, glucose, interleukin-6 (IL-6), and infection status...
2018: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/29752867/topical-application-of-culture-expanded-cd34-umbilical-cord-blood-cells-from-frozen-units-accelerates-healing-of-diabetic-skin-wounds-in-mice
#13
Jennifer Whiteley, Theresa Chow, Hibret Adissu, Armand Keating, Ian M Rogers
Chronic and nonhealing wounds are constant health issues facing patients with type 2 diabetes. As the incidence of type 2 diabetes mellitus (T2DM) increases, the incidence of chronic wounds and amputations will rise. T2DM is associated with peripheral arterial occlusive disease, which leads to the development of nonhealing skin ulcers after minor trauma. Patients develop severe pain limiting their mobility and ability to work and take care of themselves thus putting a significant burden on the family and society...
May 12, 2018: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29752845/perineal-closure-following-extralevator-abdominoperineal-excision-for-cancer-of-the-rectum
#14
Jenifer Barrie, Adam Haque, David Andrew Evans
AIM: Extralevator abdominoperineal resection (ELAP) may be complicated by perineal wound healing problems and herniation. We report a consecutive series of 38 such patients with selective use of a fasciocutaneous V-Y buttock advancement flap (BAF). METHOD: Data were collected on a series of patients undergoing ELAP for rectal malignancy between August 2011 and July 2017. Demographics, management and outcomes were recorded prospectively. Perineal wound problems were considered 'major' if they required packing, otherwise being classed as 'minor'...
May 12, 2018: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/29752337/oa-gl21-a-novel-bioactive-peptide-from-odorrana-andersonii-accelerated-the-healing-of-skin-wounds
#15
Wenxin Bian, Buliang Meng, Xiaojie Li, Siyuan Wang, Xiaoqing Cao, Naixin Liu, Meifeng Yang, Jing Tang, Ying Wang, Xinwang Yang
Nowadays, the number of chronic trauma cases caused by variety of factors such as the world's population-aging and chronic diseases is increasing steadily, and thus effective treatment for chronic wounds has become a severe clinical challenge, which also burdens the patient both physically and financially. Therefore, it is urgent to develop new drugs to accelerate the healing of wounds. Bioactive peptides, which are relatively low cost, easy to produce, store and transport, have become an excellent choice. In this research, we identified a novel peptide OA-GL21, with an amino acid sequence of 'GLLSGHYGRVVSTQSGHYGRG', from the skin secretions of Odorrana andersonii...
May 11, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29750813/autophagy-mediates-tumor-necrosis-factor-%C3%AE-induced-phenotype-switching-in-vascular-smooth-muscle-a7r5-cell-line
#16
Marina García-Miguel, Jaime A Riquelme, Ignacio Norambuena-Soto, Pablo E Morales, Fernanda Sanhueza-Olivares, Constanza Nuñez-Soto, David Mondaca-Ruff, Nicole Cancino-Arenas, Alejandra San Martín, Mario Chiong
Vascular smooth muscle cells (VSMC) dedifferentiation from a contractile to a synthetic phenotype contributes to atherosclerosis. Atherosclerotic tissue has a chronic inflammatory component with high levels of tumor necrosis factor-α (TNF-α). VSMC of atheromatous plaques have increased autophagy, a mechanism responsible for protein and intracellular organelle degradation. The aim of this study was to evaluate whether TNF-α induces phenotype switching of VSMCs and whether this effect depends on autophagy...
2018: PloS One
https://www.readbyqxmd.com/read/29746280/the-impact-of-microbial-communities-on-wound-healing-a-review
#17
Zhenzhen Xu, Henry C Hsia
Chronic, nonhealing wounds place an enormous burden on both the health care system and patients, with no definitive treatments available. There has been increasing evidence that the microbial composition of wounds may play an important role in wound healing. Culture-independent methods for bacterial detection and analysis have revealed the wound microbiome to be much more diverse and complex than culture alone. Such methods primarily rely on targeted amplification and sequencing of various hypervariable regions of the bacterial 16S rRNA for phylogenetic analysis...
April 30, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29742858/long-term-outcome-of-a-fissurectomy-a-prospective-single-arm-study-of-50-operations-out-of-349-initial-patients
#18
Jean-David Zeitoun, Pierre Blanchard, Nadia Fathallah, Paul Benfredj, Nicolas Lemarchand, Vincent de Parades
PURPOSE: The surgical standard of care for patients with chronic anal fissure is still disputed. We aimed to assess the natural course of idiopathic anal fissure and the long-term outcome of a fissurectomy as a surgical treatment. METHODS: All consecutive patients referred to a single expert practitioner in a tertiary centre were primarily included. A fissurectomy was proposed in cases of refractory symptoms after 4 to 6 weeks of standard medical management. Only patients with idiopathic and noninfected anal fissures were included in this second subsample to undergo surgery...
April 2018: Annals of Coloproctology
https://www.readbyqxmd.com/read/29742295/new-insights-into-the-roles-of-myofibroblasts-and-innervation-during-skin-healing-and-innovative-therapies-to-improve-scar-innervation
#19
REVIEW
Nicolas Lebonvallet, Betty Laverdet, Laurent Misery, Alexis Desmoulière, Dorothée Girard
During the resolution phase of normal skin wound healing, there is a considerable loss of various cell types, including myofibroblasts by apoptosis. Inappropriate delay of apoptosis, and thus increased survival of myofibroblasts, may be a factor leading to pathologies and excessive scarring. Considerable data now clearly suggests that innervation plays a major role in wound healing, including the modulation of fibroblast cellular activity. An abnormal level of neuromediators is implicated not only in the development of chronic wounds but also in excessive scar formation...
May 9, 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/29738809/assessment-of-the-mode-of-action-underlying-development-of-forestomach-tumors-in-rodents-following-oral-exposure-to-ethyl-acrylate-and-relevance-to-humans
#20
REVIEW
Chad M Thompson, Mina Suh, Grace Chappell, Susan Borghoff, Robert Ellis-Hutchings, Karin Wiench, Lavorgie Finch, Deborah M Proctor
Chronic repeated gavage dosing of high concentrations of ethyl acrylate (EA) causes forestomach tumors in rats and mice. For two decades, there has been general consensus that these tumors are unique to rodents because of: i) lack of carcinogenicity in other organs, ii) specificity to the forestomach (an organ unique to rodents which humans do not possess), iii) lack of carcinogenicity by other routes of exposure, and iv) obvious site of contact toxicity at carcinogenic doses. In 1986, EA was classified as possibly carcinogenic to humans by the International Agency for Research on Cancer (IARC)...
May 5, 2018: Regulatory Toxicology and Pharmacology: RTP
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