keyword
https://read.qxmd.com/read/38511520/association-of-tryptophan-kynurenine-metabolites-with-healing-in-chronic-venous-leg-ulcers
#21
JOURNAL ARTICLE
Junglyun Kim, Joyce Stechmiller, Michael Weaver, Debra Lyon, Timothy J Garrett, Fan Yi, Jungmin Park, Magali Rezende de Carvalho, Debra Lynch Kelly
OBJECTIVE: Chronic wound healing is a complex process that is still not well understood. The tryptophan (TRP)-L-Kynurenine (KYN) pathway has recently been under increased scrutiny in regards to wound healing. The study applied metabolomics to elucidate the TRP-L- KYN pathway associated with wound healing in chronic venous leg ulcers (CVLUs). APPROACH: This study used a longitudinal comparative design of 60 serum samples collected from 30 older adult patients with CVLUs, receiving weekly sharp debridement at a wound clinic...
March 21, 2024: Advances in Wound Care
https://read.qxmd.com/read/38511216/targeting-osteopontin-alleviates-endometriosis-and-inflammation-by-inhibiting-the-rhoa-ros-axis-and-achieves-non-invasive-in-vitro-detection-via-menstrual-blood
#22
JOURNAL ARTICLE
Han Wang, Binming Wang, Meiling Wu, Jiefang Lu, Ping Duan
STUDY QUESTION: How does osteopontin (OPN) in endometriosis ectopic stromal cells (EESCs) participate in the pathogenesis of endometriosis and achieve non-invasive detection in vitro? SUMMARY ANSWER: Targeted OPN regulates endometriosis's necroptosis and inflammatory state by inhibiting the RhoA/reactive oxygen species (ROS) axis, thereby alleviating endometriosis and enabling non-invasive detection of menstrual blood in vitro. WHAT IS KNOWN ALREADY: Endometriosis is a chronic inflammatory disease...
March 20, 2024: Human Reproduction
https://read.qxmd.com/read/38510374/lactobacillus-plantarum-promotes-wound-healing-by-inhibiting-the-nlrp3-inflammasome-and-pyroptosis-activation-in-diabetic-foot-wounds
#23
JOURNAL ARTICLE
Xiaojun Wang, Xu Li, Jianjun Liu, Yue Tao, Tao Wang, Limeng Li
OBJECTIVE: Diabetic foot ulcer (DFU) impairs the quality of life of diabetic patients and overburdens healthcare systems and society. It is crucial to comprehend the pathophysiology of DFU and develop effective treatment strategies. The aim of this study was to to evaluate the therapeutic potential of Lactobacillus Plantarum (LP) on wound healing in DFU and to explore the underlying mechanisms. METHODS: To investigate the effects of LP on wound healing, human umbilical vein endothelial cells (HUVECs) were treated with advanced glycation end products (AGEs) and used to assess cell viability, migration, and pyroptosis using CCK-8, cell scratch, and flow cytometry...
2024: Journal of Inflammation Research
https://read.qxmd.com/read/38507709/glucose-oxidase-energized-osmium-with-dual-active-centers-and-triple-enzyme-activities-for-infected-diabetic-wound-management
#24
JOURNAL ARTICLE
Shaobin He, Mengting Lin, Qionghua Zheng, Bo Liang, Xinjie He, Yin Zhang, Qiuxia Xu, Haohua Deng, Kelong Fan, Wei Chen
Diabetic wounds are susceptible to bacterial infections, largely linked to high blood glucose levels (hyperglycemia). To treat such wounds, enzymes like glucose oxidase (GOx) can be combined with nanozymes (nanomaterials mimic enzymes) to use glucose effectively for purposes. However, there is still room for improvement in these systems, particularly in terms of process simplification, enzyme activity regulation, and treatment effects. Herein, our approach utilizes GOx to directly facilitate the biomineralized growth of osmium (Os) nanozyme (GOx-OsNCs), leading to dual-active centers and remarkable triple enzyme activities...
March 20, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38507269/localized-surface-plasmon-resonance-enhanced-photocatalytic-antibacterial-of-in-situ-sprayed-0d-2d-heterojunction-composite-hydrogel-for-treating-diabetic-wound
#25
JOURNAL ARTICLE
Zhengao Wang, Wei Li, Youzhun Fan, Cairong Xiao, Zhifeng Shi, Yunbing Chang, Guoyan Liang, Chengli Liu, Zurong Zhu, Peng Yu, Xuebin Yang, Zhiguo Song, Chengyun Ning
Chronic diabetic wounds pose significant challenges due to uncontrolled bacterial infections, prolonged inflammation, and impaired angiogenesis. The rapid advancement of photo-responsive antibacterial therapy showed promise in addressing these complex issues, particularly utilizing 2D heterojunction materials, which offer unique properties. Herein, we designed an in situ sprayed Bi/BiOCl 0D/2D heterojunction composite fibrin gel with the characteristics of rapid formation and effective near-infrared activation for the treatment of non-healing diabetes-infected wounds...
March 20, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38506387/use-of-hyperbaric-oxygen-therapy-in-severe-earthquake-injuries
#26
JOURNAL ARTICLE
Levent Demir, Mustafa Öztürk
BACKGROUND: Earthquakes are natural disasters that can often cause severe injuries and traumatic situations. These injuries can include crush injuries, fractures, tissue damage, and blood circulation problems. Hyperbaric oxygen therapy (HBOT) has recently become a frequently used treatment modality for individuals suffering from severe injuries. HBOT is a form of treatment that involves administering pure oxygen to the patient under high pressure. This treatment aims to promote tissue healing by increasing cellular oxygenation...
March 2024: Turkish Journal of Trauma & Emergency Surgery: TJTES
https://read.qxmd.com/read/38505290/integrins-regulation-of-wound-healing-processes-insights-for-chronic-skin-wound-therapeutics
#27
REVIEW
Dong Yu, Zhaoyu Lu, Fengsong Nie, Yang Chong
Integrins are heterodimers composed of non-covalently associated alpha and beta subunits that mediate the dynamic linkage between extracellular adhesion molecules and the intracellular actin cytoskeleton. Integrins are present in various tissues and organs and are involved in different physiological and pathological molecular responses in vivo . Wound healing is an important process in the recovery from traumatic diseases and consists of three overlapping phases: inflammation, proliferation, and remodeling...
2024: Frontiers in Cellular and Infection Microbiology
https://read.qxmd.com/read/38504693/envoplakin-inhibits-macrophage-polarization-by-altering-the-inflammatory-tumor-microenvironment-of-melanoma-through-the-ras-erk-signaling-pathway
#28
JOURNAL ARTICLE
Weilin Cai, Minliang Chen
PURPOSE: Tumor growth induces the tumor margin to become a transition zone rich in immune cells. EVPL is a potential prognostic biomarker for melanoma. Melanoma is difficult to cure because of its high metastasis, so it is urgent to find effective genes to inhibit tumor progression and regulate tumor microenvironment. METHODS: Firstly, differentially expressed genes (DEGs) among normal skin, nevus and melanoma samples in GSE3189 were screened. Bioinformatics was used to further explore the hub genes and enriched pathways closely related to the inflammatory response of DEGs in melanoma...
2024: Journal of Inflammation Research
https://read.qxmd.com/read/38504159/igf2bp3-prevent-hmgb1-mrna-decay-in-bladder-cancer-and-development
#29
JOURNAL ARTICLE
Lei Lv, Qinqin Wei, Jianxiao Zhang, Yitong Dong, Zhenglei Shan, Na Chang, Ye Zhao, Po Bian, Qiyi Yi
BACKGROUND: IGF2BP3 functions as an RNA-binding protein (RBP) and plays a role in the posttranscriptional control of mRNA localization, stability, and translation. Its dysregulation is frequently associated with tumorigenesis across various cancer types. Nonetheless, our understanding of how the expression of the IGF2BP3 gene is regulated remains limited. The specific functions and underlying mechanisms of IGF2BP3, as well as the potential benefits of targeting it for therapeutic purposes in bladder cancer, are not yet well comprehended...
March 19, 2024: Cellular & Molecular Biology Letters
https://read.qxmd.com/read/38502912/antibacterial-fatigue-resistant-and-self-healing-dressing-from-natural-based-composite-hydrogels-for-infected-wound-healing
#30
JOURNAL ARTICLE
Ming Yan, Shi-Yu Hu, Zhi-Guo Wang, Rui Hong, Xu Peng, Maja Kuzmanović, Min Yang, Rui Dai, Yanqiong Wang, Juxiang Gou, Ka Li, Jia-Zhuang Xu, Zhong-Ming Li
The treatment of infected wounds faces substantial challenges due to the high incidence and serious infection-related complications. Natural-based hydrogel dressings with favorable antibacterial properties and strong applicability are urgently needed. Herein, we developed a composite hydrogel by constructing multiple networks and loading ciprofloxacin for infected wound healing. The hydrogel was synthesized via a Schiff base reaction between carboxymethyl chitosan and oxidized sodium alginate, followed by the polymerization of the acrylamide monomer...
March 19, 2024: Biomacromolecules
https://read.qxmd.com/read/38502535/can-telomeric-changes-orchestrate-the-development-of-autoinflammatory-skin-diseases
#31
JOURNAL ARTICLE
Ayshath Thasneem, Said Sif, Md Mizanur Rahman, Sergio Crovella
Telomeres, the safeguarding caps at the tips of chromosomes, are pivotal in the aging process of cells and have been linked to skin ailments and inflammatory conditions. Telomeres undergo a gradual reduction in length and factors such as oxidative stress hasten this diminishing process. Skin diseases including inflammatory conditions can be correlated with the shortening of telomeres and the persistent activation of DNA damage response in skin tissues. Telomere dysfunction could disrupt the balance of the skin, impairs wound healing, and may contribute to abnormal cytokine production...
March 19, 2024: Italian journal of dermatology and venereology
https://read.qxmd.com/read/38501727/study-on-chitosan-gelatin-hydrogels-containing-ceria-nanoparticles-for-promoting-the-healing-of-diabetic-wound
#32
JOURNAL ARTICLE
Yonghui Wu, Qianqian Wu, Xialian Fan, Lu Yang, Ling Zou, Qingshan Liu, Guangyou Shi, Xiaochao Yang, Keyong Tang
Chronic inflammation at diabetic wound sites results in the uncontrolled accumulation of pro-inflammatory factors and reactive oxygen species (ROS), which impedes cell proliferation and delays wound healing. To promote the healing of diabetic wounds, chitosan/gelatin hydrogels containing ceria nanoparticles (CNPs) of various sizes were created in the current study. CNPs' efficacy in removing <mml:math xmlns:mml="https://www.w3.org/1998/Math/MathML"> <mml:semantics> <mml:mrow><mml:msubsup><mml:mi>O</mml:mi> <mml:mn>2</mml:mn> <mml:mrow><mml:mo>•</mml:mo> <mml:mo>-</mml:mo></mml:mrow> </mml:msubsup> </mml:mrow> <mml:annotation>$$ {\mathrm{O}}_2^{\bullet -} $$</mml:annotation></mml:semantics> </mml:math> , •OH, and H2 O2 was demonstrated, and the scavenging ability of CNPs of varying sizes was compared...
March 19, 2024: Journal of Biomedical Materials Research. Part A
https://read.qxmd.com/read/38500151/macrophages-coordinate-immune-response-to-laser-induced-injury-via-extracellular-traps
#33
JOURNAL ARTICLE
Federica M Conedera, Despina Kokona, Martin S Zinkernagel, Jens V Stein, Charles P Lin, Clemens Alt, Volker Enzmann
BACKGROUND: Retinal degeneration results from disruptions in retinal homeostasis due to injury, disease, or aging and triggers peripheral leukocyte infiltration. Effective immune responses rely on coordinated actions of resident microglia and recruited macrophages, critical for tissue remodeling and repair. However, these phagocytes also contribute to chronic inflammation in degenerated retinas, yet the precise coordination of immune response to retinal damage remains elusive. Recent investigations have demonstrated that phagocytic cells can produce extracellular traps (ETs), which are a source of self-antigens that alter the immune response, which can potentially lead to tissue injury...
March 18, 2024: Journal of Neuroinflammation
https://read.qxmd.com/read/38499092/a-supramolecular-hydrogel-dressing-with-antibacterial-immunoregulation-and-pro-regeneration-ability-for-biofilm-associated-wound-healing
#34
JOURNAL ARTICLE
Yumeng Wang, Xinghong Zhao, Xingjian Zhou, Juqin Dai, Xiaowen Hu, Yinzi Piao, Guangyue Zu, Jian Xiao, Keqing Shi, Yong Liu, Yuanfeng Li, Linqi Shi
Chronic wound treatment has emerged as a significant healthcare concern worldwide due to its substantial economic burden and the limited effectiveness of current treatments. Effective management of biofilm infections, regulation of excessive oxidative stress, and promotion of tissue regeneration are crucial for addressing chronic wounds. Hydrogel stands out as a promising candidate for chronic wound treatment. However, its clinical application is hindered by the difficulty in designing and fabricating easily and conveniently...
March 16, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38494240/a-rapid-interactive-chitosan-based-medium-with-antioxidant-and-pro-vascularization-properties-for-infected-burn-wound-healing
#35
JOURNAL ARTICLE
Zhentao Li, Xianglong Xing, Chaoran Zhao, Qi Wu, Junjie Liu, Xiaozhong Qiu, Leyu Wang
Large-pore hydrogels are better suited to meet the management needs of nutrient transportation and gas exchange between infected burn wounds and normal tissues. However, better construction strategies are required to balance the pore size and mechanical strength of hydrogels to construct a faster substance/gas interaction medium between tissues. Herein, we developed spongy large pore size hydrogel (CS-TA@Lys) with good mechanical properties using a simple ice crystal-assisted method based on chitosan (CS), incorporating tannic acid (TA) and ε-polylysine (Lys)...
June 1, 2024: Carbohydrate Polymers
https://read.qxmd.com/read/38493953/clinical-and-biochemical-assessment-of-the-effect-of-glutamine-in-management-of-radiation-induced-oral-mucositis-in-patients-with-head-and-neck-cancer-randomized-controlled-clinical-trial
#36
JOURNAL ARTICLE
Suzan Seif Allah Ibrahim, Fatma El-Sayed Ahmed Hassanein, Hany William Zaky, Hadeel Gamal
BACKGROUND: This study aimed to evaluate the effect of oral glutamine suspension on salivary levels of transforming growth factor beta 1 (TGF-β1), a cytokine involved in inflammation and Tumor progression, and the severity of radiation-induced oral mucositis (RIOM) in head and neck cancer patients. This is the first study to investigate the impact of glutamine on TGF-β1 levels in head and neck cancer patients with radiation induced oral mucositis (RIOM). METHODS: In this randomized controlled clinical trial, 50 HNC patients were enrolled and received either glutamine oral suspension or maltodextrin as a placebo from the baseline of RIOM to the end of radiotherapy...
March 15, 2024: Journal of Stomatology, Oral and Maxillofacial Surgery
https://read.qxmd.com/read/38492705/succinylated-chitosan-derivative-restore-huvec-cells-function-damaged-by-tnf-%C3%AE-and-high-glucose-in-vitro-and-enhanced-wound-healing
#37
JOURNAL ARTICLE
Zhiwan Chen, Mengfei Yuan, Haojing Li, Lihua Li, Binghong Luo, Lu Lu, Qi Xiang, Shan Ding
The inflammation of chronic wounds plays a key hindering role in the wound healing process. Slowing down the inflammatory response is significant for the repair of chronic wounds. Studies have revealed that succinate can inactivate gastrin D (GSDMD) and prevent cell pyroptosis. Chitosan has anti-inflammatory properties and is commonly used as wound healing material. Therefore, we used succinic anhydride to modify chitosan and found that N-succinylated chitosan (NSC) was more effective in inhibiting inflammation...
March 14, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38492691/kgrt-peptide-incorporated-hydrogel-with-antibacterial-activity-for-wound-healing-by-optimizing-cellular-functions-via-erk-enos-signaling
#38
JOURNAL ARTICLE
Limin Fan, Fang Shen, Dequn Wu, Tianbin Ren, Wencheng Jiang
Bacterial infected wounds, which is characterized by easy infection, multiple inflammation and slow healing, is a complex symptom, resulting from metabolic disorder of the wound microenvironment. In this study, a series of self-healing double-network hydrogels based on KGRT peptide (Lys-Gly-Arg-Thr) with antibacterial, anti-inflammatory and optimizing cellular functions were designed to promote the healing of infected wounds with full-thickness skin defects. Moreover, the dextran hydrogelintroduces a large number of side chains, which are entangled with each other in the Schiff base network to form an interpenetrating structure...
March 14, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38491161/notoginsenoside-r1-promotes-lgr5-stem-cell-and-epithelium-renovation-in-colitis-mice-via-activating-wnt-%C3%AE-catenin-signaling
#39
JOURNAL ARTICLE
Zhi-Lun Yu, Rui-Yang Gao, Cheng Lv, Xiao-Long Geng, Yi-Jing Ren, Jing Zhang, Jun-Yu Ren, Hao Wang, Fang-Bin Ai, Zi-Yi Wang, Bei-Bei Zhang, Dong-Hui Liu, Bei Yue, Zheng-Tao Wang, Wei Dou
Inflammatory bowel disease (IBD) is characterized by persistent damage to the intestinal barrier and excessive inflammation, leading to increased intestinal permeability. Current treatments of IBD primarily address inflammation, neglecting epithelial repair. Our previous study has reported the therapeutic potential of notoginsenoside R1 (NGR1), a characteristic saponin from the root of Panax notoginseng, in alleviating acute colitis by reducing mucosal inflammation. In this study we investigated the reparative effects of NGR1 on mucosal barrier damage after the acute injury stage of DSS exposure...
March 15, 2024: Acta Pharmacologica Sinica
https://read.qxmd.com/read/38490838/inflammatory-proteins-and-neutrophil-extracellular-traps-increase-in-burn-blister-fluid-24h-after-burn
#40
JOURNAL ARTICLE
Tuo Zang, Mark W Fear, Tony J Parker, Andrew J A Holland, Lisa Martin, Donna Langley, Roy Kimble, Fiona M Wood, Leila Cuttle
Burn wound blister fluid is a valuable matrix for understanding the biological pathways associated with burn injury. In this study, 152 blister fluid samples collected from paediatric burn wounds at three different hospitals were analysed using mass spectrometry proteomic techniques. The protein abundance profile at different days after burn indicated more proteins were associated with cellular damage/repair in the first 24 h, whereas after this point more proteins were associated with antimicrobial defence...
March 1, 2024: Burns
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