Zhi-Lun Yu, Rui-Yang Gao, Cheng Lv, Xiao-Long Geng, Yi-Jing Ren, Jing Zhang, Jun-Yu Ren, Hao Wang, Fang-Bin Ai, Zi-Yi Wang, Bei-Bei Zhang, Dong-Hui Liu, Bei Yue, Zheng-Tao Wang, Wei Dou
Inflammatory bowel disease (IBD) is characterized by persistent damage to the intestinal barrier and excessive inflammation, leading to increased intestinal permeability. Current treatments of IBD primarily address inflammation, neglecting epithelial repair. Our previous study has reported the therapeutic potential of notoginsenoside R1 (NGR1), a characteristic saponin from the root of Panax notoginseng, in alleviating acute colitis by reducing mucosal inflammation. In this study we investigated the reparative effects of NGR1 on mucosal barrier damage after the acute injury stage of DSS exposure...
March 15, 2024: Acta Pharmacologica Sinica